TBPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.70547036
2fusion of sperm to egg plasma membrane (GO:0007342)7.59957884
3cell wall macromolecule catabolic process (GO:0016998)7.54139482
4cell wall macromolecule metabolic process (GO:0044036)7.54139482
5* acrosome assembly (GO:0001675)6.84363701
6sperm-egg recognition (GO:0035036)6.74014482
7multicellular organism reproduction (GO:0032504)6.71225887
8sperm motility (GO:0030317)6.01444122
9cell-cell recognition (GO:0009988)5.98773576
10plasma membrane fusion (GO:0045026)5.92572259
11axonemal dynein complex assembly (GO:0070286)5.88183656
12binding of sperm to zona pellucida (GO:0007339)5.76420955
13epithelial cilium movement (GO:0003351)5.57620947
14acrosome reaction (GO:0007340)5.55698993
15piRNA metabolic process (GO:0034587)5.22443048
16reproduction (GO:0000003)5.21581385
17cilium movement (GO:0003341)5.10819297
18male meiosis (GO:0007140)5.04169924
19CENP-A containing nucleosome assembly (GO:0034080)4.96709294
20chromatin remodeling at centromere (GO:0031055)4.88667279
21protein neddylation (GO:0045116)4.86946767
22motile cilium assembly (GO:0044458)4.85998815
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.81662972
24spermatid development (GO:0007286)4.74464397
25microtubule depolymerization (GO:0007019)4.63171901
26regulation of cilium movement (GO:0003352)4.59246146
27synaptonemal complex organization (GO:0070193)4.45424287
28proteasome assembly (GO:0043248)4.40344837
29synaptonemal complex assembly (GO:0007130)4.23240417
30single fertilization (GO:0007338)4.19731205
31DNA replication-independent nucleosome assembly (GO:0006336)3.94473005
32DNA replication-independent nucleosome organization (GO:0034724)3.94473005
33calcium ion-dependent exocytosis (GO:0017156)3.87655280
34DNA methylation involved in gamete generation (GO:0043046)3.77469055
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.72585715
36sperm capacitation (GO:0048240)3.70074022
37cell recognition (GO:0008037)3.64352913
38mitotic metaphase plate congression (GO:0007080)3.58688377
39kinetochore organization (GO:0051383)3.57666756
40kinetochore assembly (GO:0051382)3.57540951
41protein localization to kinetochore (GO:0034501)3.52306277
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.50852906
43resolution of meiotic recombination intermediates (GO:0000712)3.44155546
44protein localization to cilium (GO:0061512)3.39474612
45microtubule severing (GO:0051013)3.39259205
46ventricular system development (GO:0021591)3.38276511
47negative regulation of DNA recombination (GO:0045910)3.33776843
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.32210613
49replication fork processing (GO:0031297)3.29122364
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28981511
51fertilization (GO:0009566)3.26953100
52chromosome organization involved in meiosis (GO:0070192)3.26208475
53meiotic nuclear division (GO:0007126)3.25185497
54metaphase plate congression (GO:0051310)3.25065598
55DNA replication checkpoint (GO:0000076)3.19954968
56intraciliary transport (GO:0042073)3.18651529
57negative regulation of DNA-dependent DNA replication (GO:2000104)3.18452069
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.16811670
59NADH dehydrogenase complex assembly (GO:0010257)3.16811670
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16811670
61monoubiquitinated protein deubiquitination (GO:0035520)3.14934972
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13591589
63spermatogenesis (GO:0007283)3.12614657
64male gamete generation (GO:0048232)3.12069774
65protein localization to synapse (GO:0035418)3.11884145
66chaperone-mediated protein transport (GO:0072321)3.11776614
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11170739
68DNA replication-dependent nucleosome assembly (GO:0006335)3.10762805
69DNA replication-dependent nucleosome organization (GO:0034723)3.10762805
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09746334
71DNA ligation (GO:0006266)3.06083705
72DNA catabolic process, exonucleolytic (GO:0000738)3.05963373
73histone mRNA metabolic process (GO:0008334)3.05443007
74mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.04444872
75protein K6-linked ubiquitination (GO:0085020)3.03444820
76energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03050896
77ATP synthesis coupled proton transport (GO:0015986)3.03050896
78rRNA modification (GO:0000154)3.02081691
79organelle disassembly (GO:1903008)3.01164098
80protein polyglutamylation (GO:0018095)3.00210095
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99327611
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99327611
83protein complex biogenesis (GO:0070271)2.97820622
84spindle checkpoint (GO:0031577)2.97633820
85male meiosis I (GO:0007141)2.92121334
86mitochondrial respiratory chain complex assembly (GO:0033108)2.91986616
87regulation of centriole replication (GO:0046599)2.91201754
88regulation of DNA methylation (GO:0044030)2.90221712
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89222512
90* cellular process involved in reproduction in multicellular organism (GO:0022412)2.88668812
91gamete generation (GO:0007276)2.88243905
92attachment of spindle microtubules to kinetochore (GO:0008608)2.88207547
93termination of RNA polymerase III transcription (GO:0006386)2.86141496
94transcription elongation from RNA polymerase III promoter (GO:0006385)2.86141496
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85336499
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85336499
97negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85336499
98negative regulation of mitotic sister chromatid separation (GO:2000816)2.85336499
99negative regulation of sister chromatid segregation (GO:0033046)2.85336499
100synaptic vesicle docking involved in exocytosis (GO:0016081)2.85032192
101mitotic spindle checkpoint (GO:0071174)2.84282969
102histone H2A acetylation (GO:0043968)2.83817091
103negative regulation of inclusion body assembly (GO:0090084)2.83599994
104regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.83275595
105germ cell development (GO:0007281)2.81079383
106DNA damage response, detection of DNA damage (GO:0042769)2.80404167
107retinal cone cell development (GO:0046549)2.79964051
108maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79719353
109negative regulation of chromosome segregation (GO:0051985)2.79686809
110regulation of helicase activity (GO:0051095)2.79238229
111negative regulation of ligase activity (GO:0051352)2.77349581
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77349581
113protein K11-linked ubiquitination (GO:0070979)2.77268016
114protein localization to chromosome, centromeric region (GO:0071459)2.75572157
115DNA double-strand break processing (GO:0000729)2.73867108
116protein-cofactor linkage (GO:0018065)2.73527292
117platelet dense granule organization (GO:0060155)2.71104086
118regulation of short-term neuronal synaptic plasticity (GO:0048172)2.69525557
119histone exchange (GO:0043486)2.68756098
120rRNA methylation (GO:0031167)2.68696794
121regulation of microtubule-based movement (GO:0060632)2.67486628
122microtubule-based movement (GO:0007018)2.67155341
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.66901406
124regulation of mitotic metaphase/anaphase transition (GO:0030071)2.66901406
125establishment of chromosome localization (GO:0051303)2.66702573
126axoneme assembly (GO:0035082)2.65974511
127neuron cell-cell adhesion (GO:0007158)2.65762773
128regulation of sister chromatid segregation (GO:0033045)2.65375494
129regulation of mitotic sister chromatid separation (GO:0010965)2.65375494
130regulation of mitotic sister chromatid segregation (GO:0033047)2.65375494
131cilium organization (GO:0044782)2.64314258
132respiratory electron transport chain (GO:0022904)2.63441844
133positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.62746259
134electron transport chain (GO:0022900)2.60176347
135establishment of integrated proviral latency (GO:0075713)2.59873640
136cilium assembly (GO:0042384)2.59489637
137sequestering of actin monomers (GO:0042989)2.58606231
138mitotic spindle assembly checkpoint (GO:0007094)2.58079581
139spindle assembly checkpoint (GO:0071173)2.57649152
140purine nucleobase biosynthetic process (GO:0009113)2.56114470
141meiosis I (GO:0007127)2.54396828
142postreplication repair (GO:0006301)2.52648351
143protein targeting to mitochondrion (GO:0006626)2.51755160
144regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.48769787
145microtubule polymerization or depolymerization (GO:0031109)2.48456796
146nuclear pore complex assembly (GO:0051292)2.45546236
147cullin deneddylation (GO:0010388)2.44222058
148synaptic vesicle exocytosis (GO:0016079)2.43028725
149regulation of inclusion body assembly (GO:0090083)2.42390130
150positive regulation of synapse maturation (GO:0090129)2.39398600
151regulation of synaptic vesicle exocytosis (GO:2000300)2.38241216
152centriole replication (GO:0007099)2.33987705
153regulation of mitotic spindle checkpoint (GO:1903504)2.33745512
154regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.33745512
155GTP biosynthetic process (GO:0006183)2.33553512
156* spermatid nucleus differentiation (GO:0007289)2.30844551
157protein deneddylation (GO:0000338)2.29836088
158membrane depolarization during action potential (GO:0086010)2.29560829
159regulation of spindle checkpoint (GO:0090231)2.28283248
160centriole assembly (GO:0098534)2.28122504
161negative regulation of organelle assembly (GO:1902116)2.27961940
162single strand break repair (GO:0000012)2.27878761
163meiotic cell cycle process (GO:1903046)2.27612829
164protein-DNA complex disassembly (GO:0032986)2.27215400
165nucleosome disassembly (GO:0006337)2.27215400
166* cellular component assembly involved in morphogenesis (GO:0010927)2.26302115
167sister chromatid cohesion (GO:0007062)2.23127870
168nucleoside diphosphate phosphorylation (GO:0006165)2.22716730
169protein K11-linked deubiquitination (GO:0035871)2.21652288
170meiotic cell cycle (GO:0051321)2.21420583
171nonmotile primary cilium assembly (GO:0035058)2.20818677
172regulation of meiosis I (GO:0060631)2.20571300
173positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.20356337
174multicellular organismal reproductive process (GO:0048609)2.19629440
175nuclear pore organization (GO:0006999)2.19137425
176synapsis (GO:0007129)2.18550385
177positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.16677339
178vocalization behavior (GO:0071625)2.16626392
179deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.13560346
180regulation of synaptic vesicle transport (GO:1902803)2.13450055
181protein depolymerization (GO:0051261)2.12962431
182cilium morphogenesis (GO:0060271)2.12829145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.59405516
2EZH2_22144423_ChIP-Seq_EOC_Human4.73303743
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.06778082
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.03180097
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.52190686
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.17379312
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.94129852
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42680069
9ELK1_19687146_ChIP-ChIP_HELA_Human2.39407194
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36722740
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.33465913
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30120243
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.28166676
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.16159385
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13505430
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11964835
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.10535446
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03726980
19* VDR_23849224_ChIP-Seq_CD4+_Human2.02359947
20ZNF274_21170338_ChIP-Seq_K562_Hela2.01656897
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87386328
22* ETS1_20019798_ChIP-Seq_JURKAT_Human1.87218578
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86898308
24REST_21632747_ChIP-Seq_MESCs_Mouse1.85523678
25* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.84105801
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82581546
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82302653
28RNF2_27304074_Chip-Seq_NSC_Mouse1.82235166
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73857998
30MYC_18940864_ChIP-ChIP_HL60_Human1.71604169
31GBX2_23144817_ChIP-Seq_PC3_Human1.70162939
32* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66571381
33TAF15_26573619_Chip-Seq_HEK293_Human1.65499830
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.64229627
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63754054
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63426444
37FOXP3_21729870_ChIP-Seq_TREG_Human1.63239582
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61237784
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58147193
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57819382
41IRF1_19129219_ChIP-ChIP_H3396_Human1.56490747
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53151226
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47012540
44FUS_26573619_Chip-Seq_HEK293_Human1.45486330
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40272987
46VDR_22108803_ChIP-Seq_LS180_Human1.39398426
47SOX9_26525672_Chip-Seq_HEART_Mouse1.35065540
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34548434
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33462790
50KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.33185877
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.31903563
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31034530
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29399694
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.29191537
55* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29183910
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29171583
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.29054196
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.28986095
59* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.28818152
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.28350232
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26393316
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26253277
63SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25877650
64* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25740055
65* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23271267
66E2F7_22180533_ChIP-Seq_HELA_Human1.22847973
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22825065
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21643718
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.21522855
70P300_19829295_ChIP-Seq_ESCs_Human1.20672263
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.20164774
72MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19983415
73DCP1A_22483619_ChIP-Seq_HELA_Human1.19607476
74* EZH2_27294783_Chip-Seq_NPCs_Mouse1.17771673
75P53_22387025_ChIP-Seq_ESCs_Mouse1.15337503
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.14797053
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14790200
78* TTF2_22483619_ChIP-Seq_HELA_Human1.14311713
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13814762
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13704762
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12839009
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12482848
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.11597748
84HTT_18923047_ChIP-ChIP_STHdh_Human1.11347596
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10724332
86* FLI1_21867929_ChIP-Seq_TH2_Mouse1.10660142
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10385424
88EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10268171
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.10262272
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09698515
91* TP53_22573176_ChIP-Seq_HFKS_Human1.09188424
92KDM2B_26808549_Chip-Seq_REH_Human1.08800025
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08300348
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08133060
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.07424360
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06580877
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06486535
98P300_18555785_Chip-Seq_ESCs_Mouse1.05767117
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.05411819
100* SOX2_19829295_ChIP-Seq_ESCs_Human1.04946056
101* NANOG_19829295_ChIP-Seq_ESCs_Human1.04946056
102* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04430625
103* CBP_20019798_ChIP-Seq_JUKART_Human1.04430625
104WDR5_24793694_ChIP-Seq_LNCAP_Human1.04377089
105EST1_17652178_ChIP-ChIP_JURKAT_Human1.03189641
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03046300
107E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02933274
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02692235
109NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02441594
110ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01713285
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01195266
112* SMAD4_21799915_ChIP-Seq_A2780_Human0.99670388
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99571419
114MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99431747
115SOX2_18555785_Chip-Seq_ESCs_Mouse0.99281179
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98934755
117GABP_17652178_ChIP-ChIP_JURKAT_Human0.98163598
118OCT4_18555785_Chip-Seq_ESCs_Mouse0.97719313
119KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97672858
120STAT3_18555785_Chip-Seq_ESCs_Mouse0.97440876
121AR_21909140_ChIP-Seq_LNCAP_Human0.96766660
122* GABP_19822575_ChIP-Seq_HepG2_Human0.96418324
123* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96354424
124IGF1R_20145208_ChIP-Seq_DFB_Human0.96214870
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95610277
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95191613
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95102448
128SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95073969
129TP63_19390658_ChIP-ChIP_HaCaT_Human0.94898980
130PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94041720
131MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93376977
132EWS_26573619_Chip-Seq_HEK293_Human0.93288051
133* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.92742288
134RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92690866
135NMYC_18555785_Chip-Seq_ESCs_Mouse0.92555949
136YY1_21170310_ChIP-Seq_MESCs_Mouse0.92218498
137CTCF_18555785_Chip-Seq_ESCs_Mouse0.92074461
138RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91570932
139KLF4_18555785_Chip-Seq_ESCs_Mouse0.91470020
140BCAT_22108803_ChIP-Seq_LS180_Human0.91081510
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91057748
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91057748
143AR_25329375_ChIP-Seq_VCAP_Human0.90868218
144RARB_27405468_Chip-Seq_BRAIN_Mouse0.90414437
145POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90277017
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89718958
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89110351
148ESRRB_18555785_Chip-Seq_ESCs_Mouse0.88988071
149ER_23166858_ChIP-Seq_MCF-7_Human0.88426361
150EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85724047
151SMAD3_21741376_ChIP-Seq_EPCs_Human0.85010526
152TCF4_23295773_ChIP-Seq_U87_Human0.84759957
153FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.84738718
154EZH2_27304074_Chip-Seq_ESCs_Mouse0.84378147
155JUN_21703547_ChIP-Seq_K562_Human0.84358010
156* CRX_20693478_ChIP-Seq_RETINA_Mouse0.83590740
157KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81888484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.99439659
2MP0008877_abnormal_DNA_methylation3.98774171
3MP0002653_abnormal_ependyma_morphology3.27599803
4MP0003718_maternal_effect3.20553997
5MP0003880_abnormal_central_pattern3.15104864
6MP0004859_abnormal_synaptic_plasticity3.10602008
7* MP0003698_abnormal_male_reproductive2.93009346
8MP0009046_muscle_twitch2.61697172
9* MP0001929_abnormal_gametogenesis2.57316104
10MP0001984_abnormal_olfaction2.23576655
11MP0003635_abnormal_synaptic_transmissio2.23533196
12MP0003787_abnormal_imprinting2.04819347
13* MP0002210_abnormal_sex_determination2.04164446
14MP0001293_anophthalmia2.02468929
15MP0001968_abnormal_touch/_nociception2.02390425
16MP0008058_abnormal_DNA_repair1.92077419
17MP0002063_abnormal_learning/memory/cond1.90577757
18MP0004270_analgesia1.87934802
19MP0004147_increased_porphyrin_level1.83479443
20MP0005423_abnormal_somatic_nervous1.81883186
21MP0010094_abnormal_chromosome_stability1.77450497
22MP0009745_abnormal_behavioral_response1.77253630
23MP0002102_abnormal_ear_morphology1.71210300
24MP0002572_abnormal_emotion/affect_behav1.66837434
25* MP0001145_abnormal_male_reproductive1.65499051
26MP0000778_abnormal_nervous_system1.64604145
27MP0002736_abnormal_nociception_after1.63959836
28* MP0002161_abnormal_fertility/fecundity1.61946919
29MP0004142_abnormal_muscle_tone1.60255407
30MP0002064_seizures1.58779661
31MP0008007_abnormal_cellular_replicative1.57611248
32MP0002734_abnormal_mechanical_nocicepti1.53902738
33MP0002184_abnormal_innervation1.53456642
34MP0002735_abnormal_chemical_nociception1.52805154
35* MP0000653_abnormal_sex_gland1.52029599
36MP0001529_abnormal_vocalization1.51383043
37MP0004811_abnormal_neuron_physiology1.50674021
38MP0006276_abnormal_autonomic_nervous1.50033803
39MP0006035_abnormal_mitochondrial_morpho1.48163118
40MP0003122_maternal_imprinting1.47273702
41MP0002938_white_spotting1.42087210
42MP0002160_abnormal_reproductive_system1.39260010
43MP0002557_abnormal_social/conspecific_i1.38624528
44MP0003111_abnormal_nucleus_morphology1.37633496
45MP0003121_genomic_imprinting1.37103313
46MP0009697_abnormal_copulation1.34898549
47MP0006292_abnormal_olfactory_placode1.32936079
48MP0008789_abnormal_olfactory_epithelium1.32585885
49MP0005499_abnormal_olfactory_system1.31596299
50MP0005394_taste/olfaction_phenotype1.31596299
51MP0006036_abnormal_mitochondrial_physio1.29756043
52MP0003136_yellow_coat_color1.29405718
53MP0002067_abnormal_sensory_capabilities1.28227652
54MP0003890_abnormal_embryonic-extraembry1.27088708
55MP0003186_abnormal_redox_activity1.26320942
56MP0000569_abnormal_digit_pigmentation1.26298580
57MP0000372_irregular_coat_pigmentation1.25822370
58MP0005084_abnormal_gallbladder_morpholo1.24640497
59MP0003937_abnormal_limbs/digits/tail_de1.21589260
60MP0001188_hyperpigmentation1.20496898
61MP0002272_abnormal_nervous_system1.19984927
62MP0003567_abnormal_fetal_cardiomyocyte1.18173817
63MP0003077_abnormal_cell_cycle1.17404723
64MP0004215_abnormal_myocardial_fiber1.16230615
65MP0001486_abnormal_startle_reflex1.14325707
66MP0003861_abnormal_nervous_system1.13896838
67MP0002233_abnormal_nose_morphology1.12344575
68MP0002152_abnormal_brain_morphology1.11880153
69MP0003123_paternal_imprinting1.11007805
70MP0003786_premature_aging1.09489653
71MP0005395_other_phenotype1.09304121
72MP0008569_lethality_at_weaning1.09118522
73MP0000631_abnormal_neuroendocrine_gland1.08721096
74MP0002882_abnormal_neuron_morphology1.07885372
75MP0001440_abnormal_grooming_behavior1.07470855
76MP0002751_abnormal_autonomic_nervous1.05384127
77MP0008872_abnormal_physiological_respon1.05285136
78MP0000955_abnormal_spinal_cord1.05107687
79MP0005623_abnormal_meninges_morphology1.04192089
80MP0003693_abnormal_embryo_hatching1.01828712
81MP0002277_abnormal_respiratory_mucosa1.01655173
82MP0001485_abnormal_pinna_reflex1.00646237
83MP0000015_abnormal_ear_pigmentation0.98193769
84MP0004957_abnormal_blastocyst_morpholog0.97610692
85MP0008932_abnormal_embryonic_tissue0.96932913
86MP0005386_behavior/neurological_phenoty0.96740666
87MP0004924_abnormal_behavior0.96740666
88MP0001970_abnormal_pain_threshold0.96472571
89MP0002822_catalepsy0.96132047
90MP0001119_abnormal_female_reproductive0.95363249
91MP0001905_abnormal_dopamine_level0.95014188
92MP0002090_abnormal_vision0.94363934
93MP0001286_abnormal_eye_development0.94075798
94MP0008995_early_reproductive_senescence0.93287168
95MP0003011_delayed_dark_adaptation0.92096061
96MP0003195_calcinosis0.91120101
97MP0002733_abnormal_thermal_nociception0.91007802
98MP0000049_abnormal_middle_ear0.90737398
99MP0003938_abnormal_ear_development0.85742039
100MP0010386_abnormal_urinary_bladder0.85609320
101MP0004233_abnormal_muscle_weight0.84852296
102MP0001324_abnormal_eye_pigmentation0.84731213
103MP0005551_abnormal_eye_electrophysiolog0.82672619
104MP0002752_abnormal_somatic_nervous0.82591603
105MP0005389_reproductive_system_phenotype0.82161057
106MP0005646_abnormal_pituitary_gland0.81467499
107MP0002066_abnormal_motor_capabilities/c0.80961227
108MP0006072_abnormal_retinal_apoptosis0.80721641
109MP0010030_abnormal_orbit_morphology0.79796476
110MP0002084_abnormal_developmental_patter0.79326242
111MP0001697_abnormal_embryo_size0.78737370
112MP0000647_abnormal_sebaceous_gland0.76970794
113MP0004885_abnormal_endolymph0.76540546
114MP0005187_abnormal_penis_morphology0.75699399
115MP0003941_abnormal_skin_development0.75244289
116MP0005391_vision/eye_phenotype0.75007588
117MP0001764_abnormal_homeostasis0.74625566
118MP0003315_abnormal_perineum_morphology0.73175672
119MP0003879_abnormal_hair_cell0.72637351
120MP0008057_abnormal_DNA_replication0.72018320
121MP0003119_abnormal_digestive_system0.71589538
122MP0000358_abnormal_cell_content/0.71552822
123MP0005645_abnormal_hypothalamus_physiol0.68632587
124MP0002282_abnormal_trachea_morphology0.68241369
125MP0001501_abnormal_sleep_pattern0.68016145
126MP0002638_abnormal_pupillary_reflex0.67570075
127MP0001730_embryonic_growth_arrest0.62609570
128MP0004133_heterotaxia0.62158394
129MP0005253_abnormal_eye_physiology0.61614444
130MP0001919_abnormal_reproductive_system0.60952343
131MP0002234_abnormal_pharynx_morphology0.60469489
132MP0003385_abnormal_body_wall0.60420693
133MP0001963_abnormal_hearing_physiology0.58906739
134MP0002081_perinatal_lethality0.58775687
135MP0000350_abnormal_cell_proliferation0.57881009
136MP0000313_abnormal_cell_death0.57487103
137MP0002909_abnormal_adrenal_gland0.56979015

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.46601092
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.39887758
3Absent/shortened dynein arms (HP:0200106)7.39887758
4Abnormal respiratory motile cilium physiology (HP:0012261)6.21119735
5Abnormal respiratory motile cilium morphology (HP:0005938)5.81247919
6Abnormal respiratory epithelium morphology (HP:0012253)5.81247919
7Abnormal ciliary motility (HP:0012262)5.44210878
8Rhinitis (HP:0012384)5.25627282
9Chronic bronchitis (HP:0004469)4.18877345
10Medial flaring of the eyebrow (HP:0010747)3.92796255
11Abnormality of the labia minora (HP:0012880)3.83566873
12Gait imbalance (HP:0002141)3.61980668
13Congenital primary aphakia (HP:0007707)3.42331534
14Acute necrotizing encephalopathy (HP:0006965)3.27585811
15Nephrogenic diabetes insipidus (HP:0009806)3.17500545
16Nephronophthisis (HP:0000090)3.16174525
17Infertility (HP:0000789)3.13572079
18Acute encephalopathy (HP:0006846)3.11923103
19Bronchiectasis (HP:0002110)2.94439754
20Abnormality of midbrain morphology (HP:0002418)2.88617432
21Molar tooth sign on MRI (HP:0002419)2.88617432
22Progressive macrocephaly (HP:0004481)2.88025793
23Nasal polyposis (HP:0100582)2.86166223
24Increased hepatocellular lipid droplets (HP:0006565)2.77899351
25Abnormal mitochondria in muscle tissue (HP:0008316)2.77458105
26Mitochondrial inheritance (HP:0001427)2.76598176
27Pancreatic fibrosis (HP:0100732)2.74456366
283-Methylglutaconic aciduria (HP:0003535)2.73734492
29Meckel diverticulum (HP:0002245)2.70561735
30Focal motor seizures (HP:0011153)2.67018376
31Septo-optic dysplasia (HP:0100842)2.66918967
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.65372321
33Genital tract atresia (HP:0001827)2.63291560
34Bronchitis (HP:0012387)2.63120309
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61801374
36Increased CSF lactate (HP:0002490)2.61136973
37Abnormality of the ileum (HP:0001549)2.56198928
38Poor coordination (HP:0002370)2.55872446
39Vaginal atresia (HP:0000148)2.52768588
40Chromsome breakage (HP:0040012)2.50013887
41Abnormality of chromosome stability (HP:0003220)2.47823358
42Colon cancer (HP:0003003)2.44962710
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43014061
44Abnormality of alanine metabolism (HP:0010916)2.43014061
45Hyperalaninemia (HP:0003348)2.43014061
46Lipid accumulation in hepatocytes (HP:0006561)2.41458583
47Abnormal lung lobation (HP:0002101)2.40632606
48Methylmalonic acidemia (HP:0002912)2.40416110
49Hepatic necrosis (HP:0002605)2.38203285
50Papillary thyroid carcinoma (HP:0002895)2.37996019
51Renal Fanconi syndrome (HP:0001994)2.32473284
52Volvulus (HP:0002580)2.30615618
53Absent septum pellucidum (HP:0001331)2.30430595
54Hepatocellular necrosis (HP:0001404)2.30424366
55Amyotrophic lateral sclerosis (HP:0007354)2.30187005
56Epileptic encephalopathy (HP:0200134)2.26916272
57True hermaphroditism (HP:0010459)2.26744359
58Recurrent sinusitis (HP:0011108)2.22993068
59Abnormality of the renal medulla (HP:0100957)2.22106981
60Abnormality of the preputium (HP:0100587)2.21285146
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.20812664
62Aplasia/Hypoplasia of the lens (HP:0008063)2.19280120
63Oligodactyly (hands) (HP:0001180)2.16846879
64Microglossia (HP:0000171)2.16810079
65Febrile seizures (HP:0002373)2.15939774
66Abnormal spermatogenesis (HP:0008669)2.15817176
67Duodenal stenosis (HP:0100867)2.14005888
68Small intestinal stenosis (HP:0012848)2.14005888
69Tongue fasciculations (HP:0001308)2.13800184
70Impaired smooth pursuit (HP:0007772)2.12552534
71Hypothermia (HP:0002045)2.12252795
72Abnormality of the septum pellucidum (HP:0007375)2.12121549
73Cerebral edema (HP:0002181)2.12109711
74Myokymia (HP:0002411)2.10689096
75Atonic seizures (HP:0010819)2.07744763
76Pancreatic cysts (HP:0001737)2.07539224
77Abnormality of the nasal mucosa (HP:0000433)2.07529090
78Abnormal hair whorl (HP:0010721)2.07118637
79Chronic sinusitis (HP:0011109)2.07002224
80Abnormality of the lower motor neuron (HP:0002366)2.05440776
81Postaxial hand polydactyly (HP:0001162)2.03708013
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03609162
83Abnormality of ocular smooth pursuit (HP:0000617)2.01081377
84Abnormality of the duodenum (HP:0002246)1.99802552
85Hyperglycinemia (HP:0002154)1.98946289
86Abnormality of the heme biosynthetic pathway (HP:0010472)1.97588142
87Generalized aminoaciduria (HP:0002909)1.96053198
88Focal seizures (HP:0007359)1.96012328
89Postaxial foot polydactyly (HP:0001830)1.92283415
90Aplastic anemia (HP:0001915)1.92005724
91Progressive cerebellar ataxia (HP:0002073)1.91435600
92Supernumerary spleens (HP:0009799)1.90214963
93Recurrent otitis media (HP:0000403)1.89257534
94Increased serum lactate (HP:0002151)1.88784761
95Specific learning disability (HP:0001328)1.87955867
96Inability to walk (HP:0002540)1.87916623
97Exertional dyspnea (HP:0002875)1.87560291
98Lissencephaly (HP:0001339)1.86301700
99Short tibia (HP:0005736)1.85776517
100Triphalangeal thumb (HP:0001199)1.84757680
101Abnormality of serum amino acid levels (HP:0003112)1.83242325
102Facial cleft (HP:0002006)1.82797752
103Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82221752
104Gonadotropin excess (HP:0000837)1.82032663
105Abnormality of the anterior horn cell (HP:0006802)1.82004418
106Degeneration of anterior horn cells (HP:0002398)1.82004418
107Shoulder girdle muscle weakness (HP:0003547)1.81039166
108Cortical dysplasia (HP:0002539)1.80007159
109Abnormality of methionine metabolism (HP:0010901)1.79638117
110Birth length less than 3rd percentile (HP:0003561)1.78772068
111Muscle fibrillation (HP:0010546)1.78539228
112Sloping forehead (HP:0000340)1.78008031
113Intestinal atresia (HP:0011100)1.77660850
114Preaxial hand polydactyly (HP:0001177)1.77660269
115Degeneration of the lateral corticospinal tracts (HP:0002314)1.77410192
116Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77410192
117Abnormality of the fovea (HP:0000493)1.76974345
118Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76803166
119Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76803166
120Stenosis of the external auditory canal (HP:0000402)1.75724094
121Progressive inability to walk (HP:0002505)1.75083526
122Optic disc pallor (HP:0000543)1.74880574
123Lactic acidosis (HP:0003128)1.73281252
124Nephroblastoma (Wilms tumor) (HP:0002667)1.72600586
125Hypoglycemic coma (HP:0001325)1.72599176
126Limb dystonia (HP:0002451)1.70254630
127Male pseudohermaphroditism (HP:0000037)1.68955888
128Truncal ataxia (HP:0002078)1.68331886
129Thyroid carcinoma (HP:0002890)1.68036685
130Azoospermia (HP:0000027)1.67695956
131Optic nerve hypoplasia (HP:0000609)1.67588313
132Methylmalonic aciduria (HP:0012120)1.64901360
133Growth hormone deficiency (HP:0000824)1.64666876
134Impulsivity (HP:0100710)1.64567551
135Embryonal renal neoplasm (HP:0011794)1.64294709
136Hypoplasia of the brainstem (HP:0002365)1.63110303
137Aplasia/Hypoplasia of the brainstem (HP:0007362)1.63110303
138Broad foot (HP:0001769)1.62554276
139Impaired vibration sensation in the lower limbs (HP:0002166)1.62323481
140Median cleft lip (HP:0000161)1.59761808
141Recurrent bronchitis (HP:0002837)1.59282284
142Gaze-evoked nystagmus (HP:0000640)1.59084684
143Aganglionic megacolon (HP:0002251)1.56686227
144Atrophy/Degeneration involving motor neurons (HP:0007373)1.56007939
145Bifid tongue (HP:0010297)1.55827415
146Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55766715
147Absence seizures (HP:0002121)1.54853946
148Sclerocornea (HP:0000647)1.53889012
149Renal dysplasia (HP:0000110)1.53432902
150Visual hallucinations (HP:0002367)1.53332338
151Dental crowding (HP:0000678)1.53003540
152Oculomotor apraxia (HP:0000657)1.52338135
153Mutism (HP:0002300)1.51692140
154Anencephaly (HP:0002323)1.51571883
155Absent eyebrow (HP:0002223)1.50393206
156Male infertility (HP:0003251)1.48294468
157Absent frontal sinuses (HP:0002688)1.47529502
158Amblyopia (HP:0000646)1.47099936
159Failure to thrive in infancy (HP:0001531)1.46755923
160Occipital encephalocele (HP:0002085)1.45895907
161Narrow forehead (HP:0000341)1.45308347
162Patellar aplasia (HP:0006443)1.44743906
163Aplasia/Hypoplasia of the tibia (HP:0005772)1.44379614
164Asthma (HP:0002099)1.44367410
165Aplasia/Hypoplasia of the sternum (HP:0006714)1.42872501
166Decreased testicular size (HP:0008734)1.42585311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.59748544
2PDK44.59748544
3TRIM283.26039142
4PDK23.25901745
5TESK13.17536283
6CASK2.96986930
7MST42.85371524
8MARK12.68759333
9CCNB12.54031015
10ZAK2.51018790
11MAP2K72.50803497
12WNK32.30940015
13MAP3K122.28747252
14NTRK32.17870393
15NUAK12.13436069
16TTK2.12352798
17CDC71.98259837
18PBK1.97907903
19MINK11.95050918
20PLK21.84722264
21ERBB31.82700302
22BRSK21.80648833
23MAP4K21.77139213
24PNCK1.66661832
25MAP3K41.66207016
26BUB11.64243748
27BRSK11.61735440
28SRPK11.60259615
29ACVR1B1.57058390
30TESK21.53415245
31WEE11.52621163
32MAPK131.50405083
33PRPF4B1.48131566
34PRKD31.46560731
35PLK31.45067977
36PTK2B1.35170257
37PLK41.33434176
38MKNK11.33037159
39AKT31.32122190
40FRK1.24417771
41BMPR1B1.23687672
42VRK21.23307402
43CDK191.17022933
44KSR11.16317137
45MAP3K91.14880582
46DYRK21.14403065
47EIF2AK11.08430887
48EPHA41.08069020
49DAPK11.06624392
50NEK21.05169212
51NTRK21.01461075
52LIMK11.00887407
53STK161.00735551
54MKNK20.97090197
55PINK10.96182288
56BRAF0.95267388
57CHEK20.94722473
58GRK10.91251884
59CSNK1G10.89658502
60SIK30.88636790
61PLK10.87087650
62VRK10.86602250
63INSRR0.86112384
64ADRBK20.84526992
65RIPK40.83993602
66CDK180.83844517
67SGK20.82464310
68STK30.81758463
69YES10.80573251
70CDK140.77854632
71CSNK1G30.77399042
72OXSR10.77173146
73TLK10.76822717
74CSNK1G20.76603996
75DAPK20.76491828
76CDK150.73852677
77TSSK60.73479835
78PRKCG0.70562686
79DYRK1A0.70135456
80PAK30.67030220
81TEC0.65758558
82CHEK10.65591196
83AURKA0.64725532
84UHMK10.64450253
85CDK11A0.63970894
86STK380.63485484
87AURKB0.63020234
88TNIK0.62812039
89PKN10.60639976
90DYRK30.60626863
91CDK50.57432700
92SGK2230.57009073
93SGK4940.57009073
94ATR0.55726429
95NLK0.55370367
96CDK30.54088308
97RAF10.54062290
98TAOK30.53772974
99TAF10.53703528
100NEK10.53372754
101NEK60.52879602
102ILK0.51053712
103EIF2AK20.50014247
104CAMKK10.48197667
105BMPR20.48108774
106MUSK0.47586426
107IRAK20.47514653
108CSNK1A1L0.46878247
109TGFBR10.46400389
110STK40.46344009
111CSNK2A10.46137571
112MAP2K40.45416259
113PAK60.43836154
114PASK0.43377390
115BCR0.42804599
116MARK30.41740403
117NME10.41575377
118SCYL20.41487080
119BCKDK0.41372423
120PRKCE0.40480930
121TIE10.40451383
122CSNK1E0.39770816
123TAOK20.39631695
124WNK40.38958594
125LMTK20.37281265
126PDK10.37225826
127CAMK2A0.36323684
128CSNK2A20.35595408
129RPS6KA50.35388905
130ATM0.33581635
131ALK0.33149743
132ICK0.32262265
133EIF2AK30.31470003
134ADRBK10.31319182
135STK240.31172676
136RPS6KA40.31144225
137ARAF0.30985205
138CDK80.29378630
139GRK50.29164439
140CDK10.28045521
141RPS6KB10.27751184
142CDK20.27247909
143STK390.24022616
144STK110.22476196

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.39408615
2Nicotine addiction_Homo sapiens_hsa050332.40897141
3Synaptic vesicle cycle_Homo sapiens_hsa047212.28388026
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27856349
5Oocyte meiosis_Homo sapiens_hsa041142.13147353
6Long-term potentiation_Homo sapiens_hsa047201.95837847
7Ribosome_Homo sapiens_hsa030101.93144154
8Olfactory transduction_Homo sapiens_hsa047401.90750727
9Amphetamine addiction_Homo sapiens_hsa050311.88769719
10* Basal transcription factors_Homo sapiens_hsa030221.78980640
11Proteasome_Homo sapiens_hsa030501.77390906
12Spliceosome_Homo sapiens_hsa030401.73933274
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73927429
14Propanoate metabolism_Homo sapiens_hsa006401.62928299
15RNA transport_Homo sapiens_hsa030131.62479339
16mRNA surveillance pathway_Homo sapiens_hsa030151.61391111
17Fanconi anemia pathway_Homo sapiens_hsa034601.60637265
18Circadian entrainment_Homo sapiens_hsa047131.60560884
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59151808
20Steroid biosynthesis_Homo sapiens_hsa001001.51696996
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50433771
22Dopaminergic synapse_Homo sapiens_hsa047281.48635602
23Cell cycle_Homo sapiens_hsa041101.47827875
24DNA replication_Homo sapiens_hsa030301.44032212
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39203218
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.38706224
27Glutamatergic synapse_Homo sapiens_hsa047241.37439517
28Homologous recombination_Homo sapiens_hsa034401.34401286
29Fatty acid elongation_Homo sapiens_hsa000621.34030870
30Morphine addiction_Homo sapiens_hsa050321.32340600
31Huntingtons disease_Homo sapiens_hsa050161.28419859
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27857261
33RNA polymerase_Homo sapiens_hsa030201.25659499
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20977977
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19142212
36Taste transduction_Homo sapiens_hsa047421.17084667
37Regulation of autophagy_Homo sapiens_hsa041401.16716859
38Butanoate metabolism_Homo sapiens_hsa006501.16645609
39Base excision repair_Homo sapiens_hsa034101.15559617
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14939176
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.13100191
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11961084
43Phototransduction_Homo sapiens_hsa047441.09364508
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09256343
45One carbon pool by folate_Homo sapiens_hsa006701.08738169
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07635811
47GABAergic synapse_Homo sapiens_hsa047271.06874701
48Insulin secretion_Homo sapiens_hsa049111.06124245
49Mismatch repair_Homo sapiens_hsa034301.04454737
50Alcoholism_Homo sapiens_hsa050341.03457344
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03402921
52Renin secretion_Homo sapiens_hsa049241.02475818
53Nucleotide excision repair_Homo sapiens_hsa034201.01813022
54Collecting duct acid secretion_Homo sapiens_hsa049661.00878783
55RNA degradation_Homo sapiens_hsa030180.99294140
56Purine metabolism_Homo sapiens_hsa002300.97607603
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97418790
58Cholinergic synapse_Homo sapiens_hsa047250.96701544
59Axon guidance_Homo sapiens_hsa043600.96636436
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94311508
61Oxytocin signaling pathway_Homo sapiens_hsa049210.93952254
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93384010
63Pyrimidine metabolism_Homo sapiens_hsa002400.92606383
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90927066
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89927207
66Folate biosynthesis_Homo sapiens_hsa007900.89801290
67Calcium signaling pathway_Homo sapiens_hsa040200.89506212
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88895227
69Salivary secretion_Homo sapiens_hsa049700.88744731
70Serotonergic synapse_Homo sapiens_hsa047260.88136784
71Cocaine addiction_Homo sapiens_hsa050300.87670288
72Cardiac muscle contraction_Homo sapiens_hsa042600.86103753
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85768133
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84913603
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84007643
76Colorectal cancer_Homo sapiens_hsa052100.82233563
77Long-term depression_Homo sapiens_hsa047300.82028355
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81501299
79Pyruvate metabolism_Homo sapiens_hsa006200.80953411
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80036898
81Estrogen signaling pathway_Homo sapiens_hsa049150.79781443
82Vibrio cholerae infection_Homo sapiens_hsa051100.79140620
83* Epstein-Barr virus infection_Homo sapiens_hsa051690.78806338
84Glucagon signaling pathway_Homo sapiens_hsa049220.78278661
85Endometrial cancer_Homo sapiens_hsa052130.78158538
86Gap junction_Homo sapiens_hsa045400.76624828
87Caffeine metabolism_Homo sapiens_hsa002320.75988810
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75808533
89Glutathione metabolism_Homo sapiens_hsa004800.75710391
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75043130
91Wnt signaling pathway_Homo sapiens_hsa043100.74875190
92Sulfur metabolism_Homo sapiens_hsa009200.72890201
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70557439
94Selenocompound metabolism_Homo sapiens_hsa004500.70523569
95Non-homologous end-joining_Homo sapiens_hsa034500.69477110
96Gastric acid secretion_Homo sapiens_hsa049710.68856582
97N-Glycan biosynthesis_Homo sapiens_hsa005100.68376820
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67901746
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65455687
100Nitrogen metabolism_Homo sapiens_hsa009100.65159708
101Metabolic pathways_Homo sapiens_hsa011000.65114264
102Peroxisome_Homo sapiens_hsa041460.63944758
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.61224581
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60987677
105cAMP signaling pathway_Homo sapiens_hsa040240.60557668
106Glioma_Homo sapiens_hsa052140.60199409
107Dorso-ventral axis formation_Homo sapiens_hsa043200.59341083
108GnRH signaling pathway_Homo sapiens_hsa049120.58470501
109T cell receptor signaling pathway_Homo sapiens_hsa046600.56930651
110MAPK signaling pathway_Homo sapiens_hsa040100.55675984
111ErbB signaling pathway_Homo sapiens_hsa040120.55426439
112Melanogenesis_Homo sapiens_hsa049160.55381319
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54841240
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54404424
115Salmonella infection_Homo sapiens_hsa051320.50933840
116p53 signaling pathway_Homo sapiens_hsa041150.50175466
117Parkinsons disease_Homo sapiens_hsa050120.49965858
118Alzheimers disease_Homo sapiens_hsa050100.49589904
119Vitamin B6 metabolism_Homo sapiens_hsa007500.49403845
120Shigellosis_Homo sapiens_hsa051310.49369773
121VEGF signaling pathway_Homo sapiens_hsa043700.48731238
122Linoleic acid metabolism_Homo sapiens_hsa005910.48152558
123Endocytosis_Homo sapiens_hsa041440.47918813
124Pentose phosphate pathway_Homo sapiens_hsa000300.47486604
125Systemic lupus erythematosus_Homo sapiens_hsa053220.47433535
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46722425
127Inositol phosphate metabolism_Homo sapiens_hsa005620.45044207
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44973148
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44921322
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44845857
131Antigen processing and presentation_Homo sapiens_hsa046120.42851803
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42378805
133Oxidative phosphorylation_Homo sapiens_hsa001900.42168610
134Type I diabetes mellitus_Homo sapiens_hsa049400.41984509
1352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40220300
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40212057
137Chemical carcinogenesis_Homo sapiens_hsa052040.35307541
138TGF-beta signaling pathway_Homo sapiens_hsa043500.34817549
139Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33727181
140Arginine and proline metabolism_Homo sapiens_hsa003300.32051364
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.29859650
142Hedgehog signaling pathway_Homo sapiens_hsa043400.29731515
143Retinol metabolism_Homo sapiens_hsa008300.29558640
144beta-Alanine metabolism_Homo sapiens_hsa004100.27868230
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27753477
146Circadian rhythm_Homo sapiens_hsa047100.26789772
147Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26559950
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25296667
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25200640
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22801807
151Ether lipid metabolism_Homo sapiens_hsa005650.22597095
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21414755
153Hippo signaling pathway_Homo sapiens_hsa043900.20707698

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