TBPL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)7.64429059
2piRNA metabolic process (GO:0034587)6.62938646
3meiotic chromosome segregation (GO:0045132)6.55495675
4regulation of meiosis (GO:0040020)6.00783637
5mitotic metaphase plate congression (GO:0007080)5.90903059
6female gamete generation (GO:0007292)5.75527020
7attachment of spindle microtubules to kinetochore (GO:0008608)5.57717159
8regulation of acrosome reaction (GO:0060046)5.54703163
9meiotic cell cycle (GO:0051321)5.52654813
10notochord development (GO:0030903)5.47009112
11regulation of histone H3-K27 methylation (GO:0061085)5.37955886
12metaphase plate congression (GO:0051310)5.02331356
13negative regulation of meiosis (GO:0045835)5.00389974
14protein-chromophore linkage (GO:0018298)4.96667820
15regulation of meiotic cell cycle (GO:0051445)4.92281248
16pyrimidine nucleotide catabolic process (GO:0006244)4.75316177
17negative regulation of reproductive process (GO:2000242)4.72776550
18mitotic chromosome condensation (GO:0007076)4.60881547
19regulation of sister chromatid cohesion (GO:0007063)4.56172868
20negative regulation of smooth muscle cell differentiation (GO:0051151)4.54142477
21oocyte maturation (GO:0001556)4.53866857
22DNA methylation involved in gamete generation (GO:0043046)4.43310645
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.34928761
24negative regulation of meiotic cell cycle (GO:0051447)4.32446098
25male meiosis (GO:0007140)4.32210899
26establishment of chromosome localization (GO:0051303)4.30406420
27regulation of exit from mitosis (GO:0007096)4.27303742
28glycerophospholipid catabolic process (GO:0046475)4.26782571
29cellular response to zinc ion (GO:0071294)4.23500715
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.22290676
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.22290676
32protein K6-linked ubiquitination (GO:0085020)4.16494813
33histone H2A monoubiquitination (GO:0035518)4.12194141
34regulation of RIG-I signaling pathway (GO:0039535)4.08024346
35negative regulation of hormone metabolic process (GO:0032351)4.06831816
36negative regulation of hormone biosynthetic process (GO:0032353)4.06831816
37DNA damage induced protein phosphorylation (GO:0006975)4.04300524
38righting reflex (GO:0060013)4.00332429
39negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.00109775
40female gonad development (GO:0008585)3.92527362
41regulation of meiosis I (GO:0060631)3.91943079
42DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.91482161
43pseudouridine synthesis (GO:0001522)3.90980032
44regulation of Cdc42 GTPase activity (GO:0043088)3.87261796
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.84721276
46NADH dehydrogenase complex assembly (GO:0010257)3.84721276
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.84721276
48negative regulation of keratinocyte proliferation (GO:0010839)3.83393669
49regulation of DNA methylation (GO:0044030)3.82116071
50male meiosis I (GO:0007141)3.80027771
51DNA damage response, signal transduction resulting in transcription (GO:0042772)3.78317466
52positive regulation of Cdc42 GTPase activity (GO:0043089)3.74920340
53positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.74699496
54protein complex biogenesis (GO:0070271)3.72981740
55protein-cofactor linkage (GO:0018065)3.66243080
56sequestering of actin monomers (GO:0042989)3.66074409
57regulation of keratinocyte differentiation (GO:0045616)3.63580422
58maturation of 5.8S rRNA (GO:0000460)3.60185861
59parturition (GO:0007567)3.59177590
60DNA deamination (GO:0045006)3.59015936
61mitotic sister chromatid segregation (GO:0000070)3.58761028
62behavioral response to nicotine (GO:0035095)3.57599390
63autophagic vacuole fusion (GO:0000046)3.49655135
64type B pancreatic cell development (GO:0003323)3.46683615
65iron-sulfur cluster assembly (GO:0016226)3.45761030
66metallo-sulfur cluster assembly (GO:0031163)3.45761030
67meiosis I (GO:0007127)3.43723818
68reflex (GO:0060004)3.42872106
69regulation of centriole replication (GO:0046599)3.37825141
70mitochondrial respiratory chain complex assembly (GO:0033108)3.36534835
71multicellular organism reproduction (GO:0032504)3.35842279
72protein localization to chromosome, centromeric region (GO:0071459)3.35125099
73deoxyribonucleotide catabolic process (GO:0009264)3.34905782
74positive regulation of megakaryocyte differentiation (GO:0045654)3.33691756
75regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.32624879
76negative regulation of nuclear division (GO:0051784)3.29766015
77negative regulation of cell division (GO:0051782)3.28920838
78microtubule depolymerization (GO:0007019)3.27326864
79regulation of chronic inflammatory response (GO:0002676)3.24263586
80pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.23406993
81regulation of double-strand break repair via homologous recombination (GO:0010569)3.22525226
82ubiquinone biosynthetic process (GO:0006744)3.21595096
83negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.21544472
84CENP-A containing nucleosome assembly (GO:0034080)3.21325845
85regulation of steroid hormone secretion (GO:2000831)3.20652587
86adaptation of signaling pathway (GO:0023058)3.18819262
87gonadal mesoderm development (GO:0007506)3.17199243
88histone monoubiquitination (GO:0010390)3.15947180
89protein localization to chromosome (GO:0034502)3.14559660
90histone H2B ubiquitination (GO:0033523)3.14202863
91citrulline biosynthetic process (GO:0019240)3.13819911
92fusion of sperm to egg plasma membrane (GO:0007342)3.11257096
93ovulation cycle (GO:0042698)3.10248797
94positive regulation of histone H3-K4 methylation (GO:0051571)3.09769763
95negative regulation of telomerase activity (GO:0051974)3.09199729
96chromatin remodeling at centromere (GO:0031055)3.07784871
97kinetochore assembly (GO:0051382)3.07502480
98protein kinase C signaling (GO:0070528)3.06947789
99chromosome segregation (GO:0007059)3.04790953
100deoxyribose phosphate catabolic process (GO:0046386)3.04585713
101regulation of retinoic acid receptor signaling pathway (GO:0048385)3.04355918
102rRNA catabolic process (GO:0016075)3.02631934
103ribosomal small subunit assembly (GO:0000028)3.02325017
104histone H2A ubiquitination (GO:0033522)3.02220058
105platelet dense granule organization (GO:0060155)3.01853362
106negative regulation of DNA-templated transcription, elongation (GO:0032785)3.01778712
107negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.01778712
108base-excision repair, AP site formation (GO:0006285)3.00146881
109protein neddylation (GO:0045116)2.97046842
110positive regulation of endothelial cell differentiation (GO:0045603)2.96420824
111behavioral response to ethanol (GO:0048149)2.96336584
112positive regulation of prostaglandin secretion (GO:0032308)2.95378768
113electron transport chain (GO:0022900)2.95211446
114regulation of reproductive process (GO:2000241)2.95169262
115regulation of non-canonical Wnt signaling pathway (GO:2000050)2.95130073
116microtubule severing (GO:0051013)2.94169693
117kinetochore organization (GO:0051383)2.94105670
118regulation of keratinocyte proliferation (GO:0010837)2.93127703
119positive regulation of meiotic cell cycle (GO:0051446)2.92869687
120regulation of transforming growth factor beta2 production (GO:0032909)2.92097846
121negative regulation of mitosis (GO:0045839)2.90798187
122activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.90393399
123respiratory electron transport chain (GO:0022904)2.90093529
124oogenesis (GO:0048477)2.89694394
125mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89359356
126negative regulation of heart rate (GO:0010459)2.88613377
127adenine nucleotide transport (GO:0051503)2.88385851
128regulation of phospholipid biosynthetic process (GO:0071071)2.88050017
129regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88029702
130organ growth (GO:0035265)2.86976362
131myoblast migration (GO:0051451)2.84923084
132pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84328440
133purine ribonucleotide transport (GO:0015868)2.83399336
134histone exchange (GO:0043486)2.81912129
135positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.81393615
136positive regulation of cAMP-mediated signaling (GO:0043950)2.81152458
137mannosylation (GO:0097502)2.79705856
138regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.77499231
139positive regulation of DNA recombination (GO:0045911)2.76570539
140phosphatidylglycerol biosynthetic process (GO:0006655)2.76104794
141indolalkylamine metabolic process (GO:0006586)2.75189919
142ubiquinone metabolic process (GO:0006743)2.74987708
143regulation of activation of Janus kinase activity (GO:0010533)2.73988779
144G-protein coupled receptor internalization (GO:0002031)2.73654458
145meiotic cell cycle process (GO:1903046)2.73524469
146regulation of nuclear division (GO:0051783)2.73165433
147quinone biosynthetic process (GO:1901663)2.72914984
148regulation of mononuclear cell migration (GO:0071675)2.71824576
149positive regulation of isotype switching (GO:0045830)2.71018799
150positive regulation of meiosis (GO:0045836)2.70654226
151proteasome assembly (GO:0043248)2.69961521
152cytochrome complex assembly (GO:0017004)2.69838999
153organelle membrane fusion (GO:0090174)2.69100712
154energy coupled proton transport, down electrochemical gradient (GO:0015985)2.66649325
155ATP synthesis coupled proton transport (GO:0015986)2.66649325
156hydrogen ion transmembrane transport (GO:1902600)2.65347622
157fucose catabolic process (GO:0019317)2.61485245
158L-fucose metabolic process (GO:0042354)2.61485245
159L-fucose catabolic process (GO:0042355)2.61485245
160actin nucleation (GO:0045010)2.60283213
161negative regulation of mast cell activation (GO:0033004)2.59423080
162L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.58223757
163exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58030520
164detection of light stimulus involved in sensory perception (GO:0050962)2.56717929
165detection of light stimulus involved in visual perception (GO:0050908)2.56717929
166cytidine metabolic process (GO:0046087)2.56226977
167cytidine catabolic process (GO:0006216)2.56226977
168cytidine deamination (GO:0009972)2.56226977
169Arp2/3 complex-mediated actin nucleation (GO:0034314)2.56082043
170imidazole-containing compound metabolic process (GO:0052803)2.55899514
171ribosome biogenesis (GO:0042254)2.55093882
172preassembly of GPI anchor in ER membrane (GO:0016254)2.53251159
173pyrimidine nucleoside catabolic process (GO:0046135)2.52492379
174proton transport (GO:0015992)2.51734573
175nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51648351
176mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.51540421
177chaperone-mediated protein transport (GO:0072321)2.51282979
178negative regulation of telomere maintenance (GO:0032205)2.47386772
179indole-containing compound catabolic process (GO:0042436)2.47131113
180indolalkylamine catabolic process (GO:0046218)2.47131113
181tryptophan catabolic process (GO:0006569)2.47131113
182regulation of defense response to virus by host (GO:0050691)2.46553151
183amine biosynthetic process (GO:0009309)2.46371971
184sperm-egg recognition (GO:0035036)2.45968372
185cellular biogenic amine biosynthetic process (GO:0042401)2.45608861
186positive regulation of defense response to virus by host (GO:0002230)2.44604076
187regulation of female receptivity (GO:0045924)2.44190437
188regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.43888580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.27541011
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.95529053
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.50717782
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.35095745
5EZH2_22144423_ChIP-Seq_EOC_Human3.16764786
6NOTCH1_21737748_ChIP-Seq_TLL_Human2.75978929
7ZNF274_21170338_ChIP-Seq_K562_Hela2.63417220
8KAP1_22055183_ChIP-Seq_ESCs_Mouse2.61277162
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.58594505
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.57121737
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.50936572
12IGF1R_20145208_ChIP-Seq_DFB_Human2.49466725
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.48620187
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44191154
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.41411018
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32957049
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.32225458
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24348828
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.15738087
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.12019448
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09682219
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.05107933
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00938860
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98276494
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97870393
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97406259
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.97156409
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96450805
29RNF2_27304074_Chip-Seq_NSC_Mouse1.92388617
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.92048661
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90688291
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.88521182
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87496063
34GBX2_23144817_ChIP-Seq_PC3_Human1.86808398
35VDR_23849224_ChIP-Seq_CD4+_Human1.83819001
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.83634117
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.82799512
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79726543
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.78649045
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78046059
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76226556
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.75750121
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74562352
44* TP53_22573176_ChIP-Seq_HFKS_Human1.71934135
45SCL_19346495_ChIP-Seq_HPC-7_Human1.71328047
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69418364
47BCL6_27268052_Chip-Seq_Bcells_Human1.65858802
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63295613
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62115302
50STAT3_18555785_Chip-Seq_ESCs_Mouse1.61889653
51NANOG_20526341_ChIP-Seq_ESCs_Human1.61318867
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.60025886
53CTCF_20526341_ChIP-Seq_ESCs_Human1.59983644
54AR_21909140_ChIP-Seq_LNCAP_Human1.59827089
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59783422
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59710811
57KDM2B_26808549_Chip-Seq_REH_Human1.59587480
58* YY1_22570637_ChIP-Seq_MALME-3M_Human1.59339328
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.57430041
60VDR_22108803_ChIP-Seq_LS180_Human1.56267893
61SUZ12_18555785_Chip-Seq_ESCs_Mouse1.56163239
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55152349
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.54556168
64SOX2_18555785_Chip-Seq_ESCs_Mouse1.54055128
65NMYC_18555785_Chip-Seq_ESCs_Mouse1.53919596
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53686171
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.53485558
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53417520
69* STAT1_17558387_ChIP-Seq_HELA_Human1.52885410
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.51574748
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.49418812
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48689693
73ERA_21632823_ChIP-Seq_H3396_Human1.48373472
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.47999391
75EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.47773979
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47689347
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.47534933
78P53_22387025_ChIP-Seq_ESCs_Mouse1.47046796
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.45964583
80STAT3_23295773_ChIP-Seq_U87_Human1.45030672
81KLF4_18555785_Chip-Seq_ESCs_Mouse1.44811923
82OCT4_18555785_Chip-Seq_ESCs_Mouse1.44392667
83FUS_26573619_Chip-Seq_HEK293_Human1.42099518
84ZFX_18555785_Chip-Seq_ESCs_Mouse1.41096639
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40778574
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40715811
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40449722
88CTCF_18555785_Chip-Seq_ESCs_Mouse1.39829959
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.39173543
90ESRRB_18555785_Chip-Seq_ESCs_Mouse1.38065445
91BCOR_27268052_Chip-Seq_Bcells_Human1.37182869
92P300_18555785_Chip-Seq_ESCs_Mouse1.36410267
93P300_27268052_Chip-Seq_Bcells_Human1.36325717
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.35461495
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35420103
96MYC_18940864_ChIP-ChIP_HL60_Human1.34932482
97FOXP3_21729870_ChIP-Seq_TREG_Human1.34737424
98NCOR_22424771_ChIP-Seq_293T_Human1.34366361
99E2F1_20622854_ChIP-Seq_HELA_Human1.34244712
100TAF15_26573619_Chip-Seq_HEK293_Human1.32707613
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.32415931
102RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31514779
103EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31514779
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31200762
105ERG_20517297_ChIP-Seq_VCAP_Human1.30546089
106* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.30230943
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28925572
108RAC3_21632823_ChIP-Seq_H3396_Human1.27691440
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26475522
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26214149
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.26047152
112GATA3_26560356_Chip-Seq_TH2_Human1.25879984
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25558559
114MYC_19829295_ChIP-Seq_ESCs_Human1.25553698
115TAF2_19829295_ChIP-Seq_ESCs_Human1.25546383
116RUNX1_26923725_Chip-Seq_HPCs_Mouse1.24960175
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24843267
118SMAD4_21799915_ChIP-Seq_A2780_Human1.23925906
119ELK4_26923725_Chip-Seq_MESODERM_Mouse1.23633920
120HOXB7_26014856_ChIP-Seq_BT474_Human1.23259085
121FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22329961
122SRF_21415370_ChIP-Seq_HL-1_Mouse1.22200663
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21699473
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21601522
125FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21467899
126FOXA1_25329375_ChIP-Seq_VCAP_Human1.21467899
127OCT4_20526341_ChIP-Seq_ESCs_Human1.21136632
128CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20614951
129GABP_19822575_ChIP-Seq_HepG2_Human1.19145643
130TBL1_22424771_ChIP-Seq_293T_Human1.18666415
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18625657
132SMAD1_18555785_Chip-Seq_ESCs_Mouse1.18478827
133AR_20517297_ChIP-Seq_VCAP_Human1.17994307
134RNF2_27304074_Chip-Seq_ESCs_Mouse1.16735906
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16120470
136SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15581951
137SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15529773
138* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15518332
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15213436
140CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14276968
141TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14093647
142PU1_27457419_Chip-Seq_LIVER_Mouse1.14068491
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14025953
144SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13893595
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13310737
146TAL1_26923725_Chip-Seq_HPCs_Mouse1.12263046
147P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12231092
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11740761
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11084253
150PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10889823
151POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10326936
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10326936
153CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09612653
154EWS_26573619_Chip-Seq_HEK293_Human1.09307107
155NFYA_21822215_ChIP-Seq_K562_Human1.09195302
156OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08123397
157PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07558268
158FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07058533
159BCAT_22108803_ChIP-Seq_LS180_Human1.06536390
160SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06451636
161MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06059154
162GF1B_26923725_Chip-Seq_HPCs_Mouse1.05926802
163LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05907458
164HTT_18923047_ChIP-ChIP_STHdh_Human1.05837280
165FOXH1_21741376_ChIP-Seq_ESCs_Human1.05523618
166TCF4_23295773_ChIP-Seq_U87_Human1.05172241
167PHF8_20622854_ChIP-Seq_HELA_Human1.05155500
168AR_25329375_ChIP-Seq_VCAP_Human1.04840490
169P53_21459846_ChIP-Seq_SAOS-2_Human1.03881221
170NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03654620
171* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03607124
172CRX_20693478_ChIP-Seq_RETINA_Mouse1.03396309
173VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03001735
174LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02387209
175SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02353270
176EZH2_27304074_Chip-Seq_ESCs_Mouse1.01338830
177TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01128281
178P68_20966046_ChIP-Seq_HELA_Human1.00924761
179MYB_26560356_Chip-Seq_TH2_Human1.00188766
180HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99820490
181SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99221976
182PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97727729
183* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96727106
184IRF1_19129219_ChIP-ChIP_H3396_Human0.95004965
185SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93834273
186ELF1_20517297_ChIP-Seq_JURKAT_Human0.92630967
187E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92003799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology6.81914602
2MP0005451_abnormal_body_composition5.08593267
3MP0003718_maternal_effect4.94277884
4MP0005671_abnormal_response_to3.66037001
5MP0003787_abnormal_imprinting3.51726894
6MP0000579_abnormal_nail_morphology3.51007298
7MP0003646_muscle_fatigue3.47902792
8MP0008877_abnormal_DNA_methylation3.16994463
9MP0003693_abnormal_embryo_hatching3.00548232
10MP0002249_abnormal_larynx_morphology2.82646631
11MP0005645_abnormal_hypothalamus_physiol2.76606401
12MP0000566_synostosis2.52006551
13MP0005395_other_phenotype2.38735572
14MP0004510_myositis2.38007999
15MP0001986_abnormal_taste_sensitivity2.36184503
16MP0006292_abnormal_olfactory_placode2.34527586
17* MP0003699_abnormal_female_reproductive2.27822164
18* MP0001119_abnormal_female_reproductive2.27151240
19MP0010094_abnormal_chromosome_stability2.27026124
20MP0003315_abnormal_perineum_morphology2.21479861
21MP0004147_increased_porphyrin_level2.16493548
22MP0000685_abnormal_immune_system2.12619193
23MP0005410_abnormal_fertilization2.05557343
24MP0005464_abnormal_platelet_physiology2.01635166
25MP0009840_abnormal_foam_cell2.00599745
26MP0000678_abnormal_parathyroid_gland1.99625834
27MP0001727_abnormal_embryo_implantation1.94411424
28MP0001790_abnormal_immune_system1.93390580
29MP0005387_immune_system_phenotype1.93390580
30MP0005360_urolithiasis1.92444623
31MP0004484_altered_response_of1.90335979
32MP0003121_genomic_imprinting1.87157918
33MP0000462_abnormal_digestive_system1.74518678
34MP0005551_abnormal_eye_electrophysiolog1.73584297
35MP0005310_abnormal_salivary_gland1.71712497
36* MP0001929_abnormal_gametogenesis1.69847513
37MP0003111_abnormal_nucleus_morphology1.68015551
38MP0005646_abnormal_pituitary_gland1.65183983
39* MP0000653_abnormal_sex_gland1.64048068
40MP0001529_abnormal_vocalization1.62598680
41MP0008872_abnormal_physiological_respon1.60027964
42MP0002653_abnormal_ependyma_morphology1.56976931
43MP0002837_dystrophic_cardiac_calcinosis1.55596098
44MP0009785_altered_susceptibility_to1.55253303
45MP0004142_abnormal_muscle_tone1.54268975
46MP0000383_abnormal_hair_follicle1.51141372
47* MP0002210_abnormal_sex_determination1.51001625
48MP0006276_abnormal_autonomic_nervous1.50143470
49MP0003763_abnormal_thymus_physiology1.49868120
50MP0001800_abnormal_humoral_immune1.47294173
51MP0002095_abnormal_skin_pigmentation1.46721105
52MP0005167_abnormal_blood-brain_barrier1.45947019
53MP0003638_abnormal_response/metabolism_1.45518429
54MP0008058_abnormal_DNA_repair1.44690314
55MP0002277_abnormal_respiratory_mucosa1.44238273
56MP0010368_abnormal_lymphatic_system1.43461467
57MP0002148_abnormal_hypersensitivity_rea1.41749298
58MP0006072_abnormal_retinal_apoptosis1.39962486
59MP0001188_hyperpigmentation1.37792734
60MP0002877_abnormal_melanocyte_morpholog1.36966051
61MP0003937_abnormal_limbs/digits/tail_de1.36499261
62MP0001835_abnormal_antigen_presentation1.36068123
63MP0005000_abnormal_immune_tolerance1.35890885
64MP0005332_abnormal_amino_acid1.35160257
65MP0003724_increased_susceptibility_to1.32489082
66MP0003077_abnormal_cell_cycle1.30685258
67MP0005408_hypopigmentation1.29114041
68MP0004133_heterotaxia1.28451511
69MP0002723_abnormal_immune_serum1.25974532
70MP0000427_abnormal_hair_cycle1.25829572
71MP0010678_abnormal_skin_adnexa1.25384417
72MP0003186_abnormal_redox_activity1.24593156
73MP0002736_abnormal_nociception_after1.20956513
74MP0002452_abnormal_antigen_presenting1.20683199
75MP0000026_abnormal_inner_ear1.19783273
76MP0002420_abnormal_adaptive_immunity1.19137877
77MP0001501_abnormal_sleep_pattern1.18863659
78MP0003938_abnormal_ear_development1.18855897
79MP0005025_abnormal_response_to1.18738357
80MP0001905_abnormal_dopamine_level1.18083552
81MP0004264_abnormal_extraembryonic_tissu1.15041593
82MP0001819_abnormal_immune_cell1.14774647
83MP0002735_abnormal_chemical_nociception1.13683431
84MP0003183_abnormal_peptide_metabolism1.12184034
85MP0002139_abnormal_hepatobiliary_system1.11637910
86* MP0002161_abnormal_fertility/fecundity1.10177964
87MP0008004_abnormal_stomach_pH1.08631930
88MP0004185_abnormal_adipocyte_glucose1.07965563
89MP0008932_abnormal_embryonic_tissue1.06807467
90MP0004957_abnormal_blastocyst_morpholog1.06526495
91MP0000230_abnormal_systemic_arterial1.06510325
92MP0001145_abnormal_male_reproductive1.05630865
93MP0004885_abnormal_endolymph1.04592385
94MP0003436_decreased_susceptibility_to1.03433042
95MP0004859_abnormal_synaptic_plasticity1.03038609
96MP0008875_abnormal_xenobiotic_pharmacok1.00790661
97MP0002160_abnormal_reproductive_system1.00720492
98MP0000490_abnormal_crypts_of0.99936266
99MP0003195_calcinosis0.99890549
100MP0002234_abnormal_pharynx_morphology0.99160716
101MP0009764_decreased_sensitivity_to0.99081727
102MP0001486_abnormal_startle_reflex0.97268433
103MP0000372_irregular_coat_pigmentation0.95473287
104MP0005174_abnormal_tail_pigmentation0.95354853
105MP0001348_abnormal_lacrimal_gland0.95004341
106MP0000716_abnormal_immune_system0.94724558
107MP0010155_abnormal_intestine_physiology0.94344862
108MP0005647_abnormal_sex_gland0.93989312
109MP0009643_abnormal_urine_homeostasis0.91550978
110MP0009384_cardiac_valve_regurgitation0.91431294
111MP0001346_abnormal_lacrimal_gland0.89781713
112MP0004742_abnormal_vestibular_system0.89064473
113MP0008057_abnormal_DNA_replication0.88800474
114MP0001970_abnormal_pain_threshold0.87542659
115MP0010234_abnormal_vibrissa_follicle0.87030397
116MP0003329_amyloid_beta_deposits0.86868421
117MP0003866_abnormal_defecation0.86102194
118MP0001963_abnormal_hearing_physiology0.85921356
119MP0005389_reproductive_system_phenotype0.85775220
120MP0000639_abnormal_adrenal_gland0.84625996
121MP0010386_abnormal_urinary_bladder0.84368839
122MP0001968_abnormal_touch/_nociception0.84085202
123MP0000689_abnormal_spleen_morphology0.83308035
124MP0002398_abnormal_bone_marrow0.82878263
125MP0002229_neurodegeneration0.82828266
126MP0002693_abnormal_pancreas_physiology0.82752144
127MP0003879_abnormal_hair_cell0.82559254
128MP0002282_abnormal_trachea_morphology0.81143294
129MP0000762_abnormal_tongue_morphology0.80142200
130MP0009333_abnormal_splenocyte_physiolog0.79155688
131MP0001765_abnormal_ion_homeostasis0.78851737
132MP0002876_abnormal_thyroid_physiology0.78783281
133MP0003755_abnormal_palate_morphology0.78716894
134MP0006036_abnormal_mitochondrial_physio0.77291575
135MP0008995_early_reproductive_senescence0.77009723
136MP0000538_abnormal_urinary_bladder0.76983403
137MP0009379_abnormal_foot_pigmentation0.76026682
138MP0002177_abnormal_outer_ear0.76007510
139MP0001845_abnormal_inflammatory_respons0.74293948
140MP0002419_abnormal_innate_immunity0.73234389
141MP0009278_abnormal_bone_marrow0.73224121
142MP0005187_abnormal_penis_morphology0.71719577
143MP0000613_abnormal_salivary_gland0.71416137
144MP0002098_abnormal_vibrissa_morphology0.70361200
145MP0003880_abnormal_central_pattern0.69330312
146MP0000631_abnormal_neuroendocrine_gland0.67994902
147MP0002932_abnormal_joint_morphology0.67453825
148MP0002295_abnormal_pulmonary_circulatio0.67116624
149MP0002116_abnormal_craniofacial_bone0.67027317
150MP0009250_abnormal_appendicular_skeleto0.65976627
151MP0002734_abnormal_mechanical_nocicepti0.64811213
152MP0003123_paternal_imprinting0.64623884
153MP0003698_abnormal_male_reproductive0.64298650
154MP0003453_abnormal_keratinocyte_physiol0.63133069
155MP0001502_abnormal_circadian_rhythm0.62546629
156MP0002168_other_aberrant_phenotype0.62376732
157MP0001919_abnormal_reproductive_system0.60198938
158MP0002184_abnormal_innervation0.59038829
159MP0003136_yellow_coat_color0.58773076
160MP0005257_abnormal_intraocular_pressure0.55287328
161MP0004782_abnormal_surfactant_physiolog0.55030640
162MP0002085_abnormal_embryonic_tissue0.54738427
163MP0000627_abnormal_mammary_gland0.54459143
164MP0002752_abnormal_somatic_nervous0.53545774
165MP0005367_renal/urinary_system_phenotyp0.51762233
166MP0000516_abnormal_urinary_system0.51762233
167MP0002233_abnormal_nose_morphology0.50127080
168MP0005381_digestive/alimentary_phenotyp0.48092622
169MP0002733_abnormal_thermal_nociception0.47944193

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)6.88047140
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.22484608
3Chromsome breakage (HP:0040012)5.16363352
4Cortical dysplasia (HP:0002539)5.16000338
5Increased hepatocellular lipid droplets (HP:0006565)3.76482555
6Lipid accumulation in hepatocytes (HP:0006561)3.68192249
73-Methylglutaconic aciduria (HP:0003535)3.56834781
8Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.45492599
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.43355858
10Abnormality of alanine metabolism (HP:0010916)3.43355858
11Hyperalaninemia (HP:0003348)3.43355858
12Mitochondrial inheritance (HP:0001427)3.42017512
13Stomatitis (HP:0010280)3.36702893
14Abnormality of chromosome segregation (HP:0002916)3.35897246
15Generalized aminoaciduria (HP:0002909)3.33934136
16Renal Fanconi syndrome (HP:0001994)3.30231364
17Tetany (HP:0001281)3.22184632
18Abnormality of the renal collecting system (HP:0004742)3.17136089
19Acute necrotizing encephalopathy (HP:0006965)3.11968235
20Hepatocellular necrosis (HP:0001404)3.10480104
21Type II lissencephaly (HP:0007260)3.08770520
22Exertional dyspnea (HP:0002875)3.07750694
23Increased CSF lactate (HP:0002490)3.07181824
24Abnormality of the labia minora (HP:0012880)3.06745225
25Abnormal sex determination (HP:0012244)3.05208587
26Sex reversal (HP:0012245)3.05208587
27True hermaphroditism (HP:0010459)3.03914196
28Vacuolated lymphocytes (HP:0001922)3.02217794
29Upper limb muscle weakness (HP:0003484)3.01674630
30Prostate neoplasm (HP:0100787)2.99820167
31Villous atrophy (HP:0011473)2.98409485
32Abnormality of small intestinal villus morphology (HP:0011472)2.98409485
33Duplicated collecting system (HP:0000081)2.96969914
34Facial hemangioma (HP:0000329)2.95115656
35Papillary thyroid carcinoma (HP:0002895)2.95080653
36Hepatic necrosis (HP:0002605)2.95013135
37Congenital stationary night blindness (HP:0007642)2.93939973
38Hypergonadotropic hypogonadism (HP:0000815)2.93514093
39Adrenal hypoplasia (HP:0000835)2.90413475
40Infertility (HP:0000789)2.89445398
41Constricted visual fields (HP:0001133)2.88668932
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.75774789
43Hypoplasia of the fovea (HP:0007750)2.75774789
44Arterial tortuosity (HP:0005116)2.74056067
45Abnormality of the fovea (HP:0000493)2.72542361
46Unilateral renal agenesis (HP:0000122)2.70906128
47Congenital sensorineural hearing impairment (HP:0008527)2.70181579
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.62685260
49Flat capital femoral epiphysis (HP:0003370)2.62522729
50Primary amenorrhea (HP:0000786)2.62478572
51Reticulocytopenia (HP:0001896)2.62101636
52Abnormal mitochondria in muscle tissue (HP:0008316)2.56928602
53IgG deficiency (HP:0004315)2.56420810
54Abnormal rod and cone electroretinograms (HP:0008323)2.56364392
55Lip pit (HP:0100267)2.55425055
56Shawl scrotum (HP:0000049)2.55374515
57Cerebellar dysplasia (HP:0007033)2.50894592
58Fetal akinesia sequence (HP:0001989)2.50223727
59Acute encephalopathy (HP:0006846)2.49632749
60Secondary amenorrhea (HP:0000869)2.49329552
61Pendular nystagmus (HP:0012043)2.49165088
62Patellar aplasia (HP:0006443)2.49085500
63Abnormality of midbrain morphology (HP:0002418)2.46988284
64Molar tooth sign on MRI (HP:0002419)2.46988284
65Increased intramyocellular lipid droplets (HP:0012240)2.46832281
66Increased serum lactate (HP:0002151)2.46763950
67Aplasia involving bones of the upper limbs (HP:0009823)2.46092207
68Aplasia of the phalanges of the hand (HP:0009802)2.46092207
69Aplasia involving bones of the extremities (HP:0009825)2.46092207
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.45704765
71Glycosuria (HP:0003076)2.45358003
72Abnormality of urine glucose concentration (HP:0011016)2.45358003
73Progressive macrocephaly (HP:0004481)2.43094544
74Oligodactyly (hands) (HP:0001180)2.38955971
75Aplastic anemia (HP:0001915)2.37456832
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37280265
77Nephroblastoma (Wilms tumor) (HP:0002667)2.36426442
78Abnormality of lateral ventricle (HP:0030047)2.34637801
79Prolonged bleeding time (HP:0003010)2.33035967
80Premature ovarian failure (HP:0008209)2.32877355
81Breast hypoplasia (HP:0003187)2.31362317
82Attenuation of retinal blood vessels (HP:0007843)2.31119636
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.31106397
84Pancreatic fibrosis (HP:0100732)2.30562912
85Decreased central vision (HP:0007663)2.30472806
86Vascular tortuosity (HP:0004948)2.29156812
87Febrile seizures (HP:0002373)2.25804462
88Oligodactyly (HP:0012165)2.25746758
89Increased neuronal autofluorescent lipopigment (HP:0002074)2.25112295
90Male pseudohermaphroditism (HP:0000037)2.25040940
91Aplasia/Hypoplasia of the breasts (HP:0010311)2.23763753
92Capillary hemangiomas (HP:0005306)2.22828797
93Aplasia/Hypoplasia of the patella (HP:0006498)2.21210483
94Cerebral edema (HP:0002181)2.19923215
95Aplasia cutis congenita (HP:0001057)2.19371573
96Abolished electroretinogram (ERG) (HP:0000550)2.17906999
97Embryonal renal neoplasm (HP:0011794)2.17796927
98Nonprogressive disorder (HP:0003680)2.16976964
99Short thumb (HP:0009778)2.16871018
100Increased muscle lipid content (HP:0009058)2.16583931
101Nausea (HP:0002018)2.16516888
102Wrist flexion contracture (HP:0001239)2.16503352
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15495337
104Insulin-resistant diabetes mellitus (HP:0000831)2.15141963
105Abnormality of the preputium (HP:0100587)2.14857255
106Breast aplasia (HP:0100783)2.13642983
107Birth length less than 3rd percentile (HP:0003561)2.13026782
108Spontaneous hematomas (HP:0007420)2.09511592
109Small intestinal stenosis (HP:0012848)2.09373930
110Duodenal stenosis (HP:0100867)2.09373930
111Panhypogammaglobulinemia (HP:0003139)2.09165980
112Increased IgM level (HP:0003496)2.08696321
113Severe visual impairment (HP:0001141)2.08585552
114Absent septum pellucidum (HP:0001331)2.08059394
115Decreased muscle mass (HP:0003199)2.06396456
116Pulmonary fibrosis (HP:0002206)2.06364450
117Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.06138791
118Short 1st metacarpal (HP:0010034)2.06138791
119Recurrent cutaneous fungal infections (HP:0011370)2.05003255
120Chronic mucocutaneous candidiasis (HP:0002728)2.05003255
121Abnormality of chromosome stability (HP:0003220)2.04681739
122Respiratory difficulties (HP:0002880)2.04448564
123Abnormality of the renal cortex (HP:0011035)2.04442632
124Petechiae (HP:0000967)2.04327203
125Absent thumb (HP:0009777)2.03374608
126Lactic acidosis (HP:0003128)2.01270413
127Hypoplasia of the uterus (HP:0000013)2.01221969
128Absent radius (HP:0003974)1.99503884
129Limb dystonia (HP:0002451)1.98890422
130Hypothermia (HP:0002045)1.98226584
131Distal lower limb amyotrophy (HP:0008944)1.98124380
132Nephronophthisis (HP:0000090)1.97750445
133Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97728730
134Abnormality of the aortic arch (HP:0012303)1.97384318
135Abnormality of the fingertips (HP:0001211)1.97113617
136Abnormality of renal resorption (HP:0011038)1.95759336
137Absent forearm bone (HP:0003953)1.95134162
138Aplasia involving forearm bones (HP:0009822)1.95134162
139Rib fusion (HP:0000902)1.94904167
140Optic nerve hypoplasia (HP:0000609)1.94719398
141Abnormal drinking behavior (HP:0030082)1.93019324
142Polydipsia (HP:0001959)1.93019324
143Meckel diverticulum (HP:0002245)1.91807301
144Aplasia/Hypoplasia of the earlobes (HP:0009906)1.91464995
145Septo-optic dysplasia (HP:0100842)1.90597184
146Optic disc pallor (HP:0000543)1.89707541
147Abnormality of the renal medulla (HP:0100957)1.88491996
148Cerebral hypomyelination (HP:0006808)1.87601111
149Aplasia/Hypoplasia of the macula (HP:0008059)1.87536153
150Inability to walk (HP:0002540)1.86537551
151Deep venous thrombosis (HP:0002625)1.85758351
152Pancreatic cysts (HP:0001737)1.84822860
153Acute myeloid leukemia (HP:0004808)1.84526029
154Hyperphosphaturia (HP:0003109)1.84444707
155Cholecystitis (HP:0001082)1.83835614
156Abnormal gallbladder physiology (HP:0012438)1.83835614
157Anomalous pulmonary venous return (HP:0010772)1.82504375
158Atelectasis (HP:0100750)1.82155959
159Midline defect of the nose (HP:0004122)1.82089653
160Ectopic kidney (HP:0000086)1.81787301
161Abnormality of male internal genitalia (HP:0000022)1.81187641
162Chin dimple (HP:0010751)1.81135691
163Abnormal biliary tract physiology (HP:0012439)1.80620940
164Bile duct proliferation (HP:0001408)1.80620940
165Bifid scrotum (HP:0000048)1.80509576
166Poor speech (HP:0002465)1.80194759
167Chorioretinal atrophy (HP:0000533)1.80077474
168Paralysis (HP:0003470)1.79919193
169Renal cortical cysts (HP:0000803)1.79114423
170Abnormality of the ileum (HP:0001549)1.77961502
171Elevated erythrocyte sedimentation rate (HP:0003565)1.77674985
172Fibular aplasia (HP:0002990)1.77497253
173Supernumerary spleens (HP:0009799)1.76189652
174Abnormality of placental membranes (HP:0011409)1.76162230
175Amniotic constriction ring (HP:0009775)1.76162230
176Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74978323
177Hypomagnesemia (HP:0002917)1.72412061
178Aplasia/Hypoplasia of the spleen (HP:0010451)1.71900247
179Type 2 muscle fiber atrophy (HP:0003554)1.70325075
180Abnormality of macrophages (HP:0004311)1.69984407
181Aplasia/Hypoplasia affecting the retina (HP:0008061)1.69854940
182Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.68918209
183Lissencephaly (HP:0001339)1.68383852
184Asplenia (HP:0001746)1.68152103
185Increased cerebral lipofuscin (HP:0011813)1.67962824
186Menorrhagia (HP:0000132)1.67930502
187Bony spicule pigmentary retinopathy (HP:0007737)1.66802599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L4.73942730
2TESK24.21714127
3MAP3K63.93815682
4MUSK3.77895142
5TAOK33.70616227
6ERBB43.42762155
7MAP4K23.37568731
8MAP4K13.26115579
9MOS3.01941838
10TTK2.99417577
11KDR2.92868390
12EEF2K2.90584121
13WNK42.88228960
14TXK2.87234670
15BMPR22.86643494
16LATS12.71793760
17LATS22.65442677
18PLK42.50039441
19ZAK2.40170723
20ADRBK22.34403233
21MAP3K112.32018155
22BRAF2.28853026
23CDK92.27827262
24KSR22.21839975
25VRK22.20297197
26TLK12.10640421
27MAP3K132.09128571
28CASK2.02263359
29DMPK1.91583819
30MAP3K91.90094230
31EPHA41.81246903
32TAOK11.81051439
33CDK191.80863263
34TRPM71.79500499
35CDK81.75830259
36MAP3K41.68059684
37BCKDK1.66329438
38MAPKAPK31.57989114
39MAP2K71.54073846
40ACVR1B1.51189123
41BLK1.44392847
42MELK1.44174510
43CHEK21.43014830
44PAK61.41855891
45RAF11.41674922
46PRKD21.40374320
47STK161.39724790
48PBK1.35233668
49SYK1.34382994
50BTK1.24957345
51STK101.21356802
52MAPK131.19786025
53MAPKAPK51.19586252
54MYLK1.19321715
55IKBKB1.17127504
56MAP3K121.11797451
57SCYL21.08640066
58CDC71.06990962
59PLK11.01055893
60STK381.00825024
61GRK61.00226763
62ARAF0.96729236
63LMTK20.95238853
64BMX0.95177169
65LIMK10.93159784
66DYRK30.90823510
67NUAK10.90254283
68NME10.89901288
69STK30.89119185
70IRAK40.86976125
71IRAK30.86851513
72STK240.84131722
73STK390.83953996
74TRIM280.82837499
75PRKAA20.82400757
76MATK0.81765837
77BCR0.81485686
78ADRBK10.80075186
79TEC0.79831473
80ZAP700.79068886
81MAPK110.78596434
82CDK30.78092013
83DYRK20.76396152
84PHKG20.76075380
85PHKG10.76075380
86KSR10.74967628
87CDK40.74138642
88NTRK20.73540396
89MAP2K40.72394956
90TESK10.72209307
91LYN0.70936122
92NLK0.69968821
93JAK30.68360911
94RPS6KA50.68070987
95PKN10.65599678
96ITK0.65359146
97CSNK1G10.63319861
98MAP3K80.62950618
99EIF2AK20.62848295
100CAMK2D0.61784215
101MST40.61741706
102CSF1R0.59228405
103DAPK10.59004030
104EIF2AK30.58825769
105NTRK10.58195612
106PAK30.57736389
107AURKB0.57399572
108MAPK150.56612624
109TYRO30.55744698
110PLK20.55468666
111TBK10.55429738
112PIM20.55363657
113OBSCN0.54324873
114PRKD30.53988678
115DAPK30.53312212
116LCK0.52154710
117PIK3CG0.50641812
118PAK10.50494740
119FES0.49453325
120KIT0.49166259
121PRKAA10.48692020
122NTRK30.48010450
123CAMK2A0.47300142
124CSNK1G30.46071296
125CAMK2G0.45432007
126FRK0.44563342
127PTK2B0.43753311
128CSNK1A10.43139604
129PRKACA0.42894204
130VRK10.42892030
131EPHB20.42574438
132RET0.42504109
133HCK0.42318179
134PRKCI0.41512482
135CSNK2A10.41226488
136PRKG20.41033929
137PIM10.39795814
138NEK20.39443776
139GRK50.39108307
140MARK30.37958284
141PNCK0.37806141
142SGK20.37467889
143PINK10.36761122
144CSK0.36645057
145PRKG10.35494847
146TNK20.35038932
147PRKCE0.34857835
148CSNK1A1L0.34750334
149MARK20.34409846
150WNK10.33560875
151GRK10.33352843
152TIE10.33344254
153FGR0.33226468
154STK110.33222115
155CSNK1G20.32745217
156DAPK20.32547508
157ATM0.32203297
158TAF10.31906622
159TAOK20.31281270
160MAP3K50.31050600
161TNIK0.27888783
162RPS6KB20.27210516
163ABL20.27178486
164AURKA0.27030737
165OXSR10.26740016
166PLK30.26412146
167EIF2AK10.25902178
168WNK30.25080595
169BMPR1B0.24577954
170SGK4940.22115273
171SGK2230.22115273
172ABL10.19382277
173ALK0.19379334
174IKBKE0.17255789
175CDK60.16386960
176CSNK1D0.15713414
177ROCK20.15399800
178SGK10.13930349

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049133.94884136
2Oxidative phosphorylation_Homo sapiens_hsa001903.74859207
3Cell cycle_Homo sapiens_hsa041103.29251955
4Primary immunodeficiency_Homo sapiens_hsa053403.23835733
5Parkinsons disease_Homo sapiens_hsa050123.09230333
6RNA degradation_Homo sapiens_hsa030182.70384878
7Ribosome_Homo sapiens_hsa030102.56405359
8Fanconi anemia pathway_Homo sapiens_hsa034602.47204127
9Ether lipid metabolism_Homo sapiens_hsa005652.40512384
10Non-homologous end-joining_Homo sapiens_hsa034502.38850959
11Pancreatic cancer_Homo sapiens_hsa052122.37060656
12Sulfur metabolism_Homo sapiens_hsa009202.30606568
13Circadian rhythm_Homo sapiens_hsa047102.21594298
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15768206
15Linoleic acid metabolism_Homo sapiens_hsa005912.14324457
16Collecting duct acid secretion_Homo sapiens_hsa049662.14231204
17GnRH signaling pathway_Homo sapiens_hsa049122.14169247
18Oocyte meiosis_Homo sapiens_hsa041142.08334532
19Sulfur relay system_Homo sapiens_hsa041222.01291180
20Cardiac muscle contraction_Homo sapiens_hsa042601.98710787
21Dorso-ventral axis formation_Homo sapiens_hsa043201.95087129
22Huntingtons disease_Homo sapiens_hsa050161.92069224
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90414086
24TGF-beta signaling pathway_Homo sapiens_hsa043501.84868874
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81863850
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.79836107
27Folate biosynthesis_Homo sapiens_hsa007901.77347635
28* Basal transcription factors_Homo sapiens_hsa030221.72135338
29Homologous recombination_Homo sapiens_hsa034401.70876663
30Proteasome_Homo sapiens_hsa030501.66415843
31Regulation of autophagy_Homo sapiens_hsa041401.64886969
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59291872
33Alzheimers disease_Homo sapiens_hsa050101.56573839
34Nicotine addiction_Homo sapiens_hsa050331.55393071
35p53 signaling pathway_Homo sapiens_hsa041151.55334559
36Asthma_Homo sapiens_hsa053101.55136819
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52895307
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46112337
39Vitamin B6 metabolism_Homo sapiens_hsa007501.42918918
40Histidine metabolism_Homo sapiens_hsa003401.36602310
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36073546
42Glutamatergic synapse_Homo sapiens_hsa047241.35849385
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28997418
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25426739
45Allograft rejection_Homo sapiens_hsa053301.25183072
46Ras signaling pathway_Homo sapiens_hsa040141.23026910
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22764085
48Selenocompound metabolism_Homo sapiens_hsa004501.21617388
49Choline metabolism in cancer_Homo sapiens_hsa052311.19875867
50Serotonergic synapse_Homo sapiens_hsa047261.19829541
51Long-term depression_Homo sapiens_hsa047301.18942000
52RNA polymerase_Homo sapiens_hsa030201.14939443
53Autoimmune thyroid disease_Homo sapiens_hsa053201.13554111
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.13436705
55MicroRNAs in cancer_Homo sapiens_hsa052061.13129963
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13012189
57Prolactin signaling pathway_Homo sapiens_hsa049171.06209334
58Rheumatoid arthritis_Homo sapiens_hsa053231.03435013
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99831114
60Malaria_Homo sapiens_hsa051440.99487581
61Protein export_Homo sapiens_hsa030600.99044932
62Non-small cell lung cancer_Homo sapiens_hsa052230.98720446
63Pyrimidine metabolism_Homo sapiens_hsa002400.97802489
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96349818
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.95980032
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.93472637
67Small cell lung cancer_Homo sapiens_hsa052220.88938617
68One carbon pool by folate_Homo sapiens_hsa006700.88543751
69VEGF signaling pathway_Homo sapiens_hsa043700.87350840
70Olfactory transduction_Homo sapiens_hsa047400.86697567
71cAMP signaling pathway_Homo sapiens_hsa040240.85818012
72Fat digestion and absorption_Homo sapiens_hsa049750.84534013
73Sphingolipid metabolism_Homo sapiens_hsa006000.84421666
74Bladder cancer_Homo sapiens_hsa052190.83733692
75Phototransduction_Homo sapiens_hsa047440.83326501
76Nitrogen metabolism_Homo sapiens_hsa009100.83119976
77Amphetamine addiction_Homo sapiens_hsa050310.81603430
78Notch signaling pathway_Homo sapiens_hsa043300.79484711
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78429475
80Glioma_Homo sapiens_hsa052140.77921996
81Butanoate metabolism_Homo sapiens_hsa006500.77701149
82Melanoma_Homo sapiens_hsa052180.77674144
83Hippo signaling pathway_Homo sapiens_hsa043900.76788108
84Cocaine addiction_Homo sapiens_hsa050300.76299704
85FoxO signaling pathway_Homo sapiens_hsa040680.76093562
86Base excision repair_Homo sapiens_hsa034100.75823988
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.74968350
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.74914845
89Arachidonic acid metabolism_Homo sapiens_hsa005900.74026399
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73699233
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.73047159
92Retinol metabolism_Homo sapiens_hsa008300.72426961
93Steroid biosynthesis_Homo sapiens_hsa001000.70831213
94Colorectal cancer_Homo sapiens_hsa052100.70326249
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70259683
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69427558
97MAPK signaling pathway_Homo sapiens_hsa040100.68925784
98Platelet activation_Homo sapiens_hsa046110.68801855
99ErbB signaling pathway_Homo sapiens_hsa040120.68765003
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.66843575
101T cell receptor signaling pathway_Homo sapiens_hsa046600.66804157
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66801139
103Tryptophan metabolism_Homo sapiens_hsa003800.66653941
104Metabolic pathways_Homo sapiens_hsa011000.65174746
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.64820394
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64153192
107Vitamin digestion and absorption_Homo sapiens_hsa049770.64025928
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63777505
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63771354
110Synaptic vesicle cycle_Homo sapiens_hsa047210.63507095
111Estrogen signaling pathway_Homo sapiens_hsa049150.62918065
112Oxytocin signaling pathway_Homo sapiens_hsa049210.61461088
113RNA transport_Homo sapiens_hsa030130.61272596
114Morphine addiction_Homo sapiens_hsa050320.60955223
115Type I diabetes mellitus_Homo sapiens_hsa049400.60201612
116Prostate cancer_Homo sapiens_hsa052150.60115488
117Taste transduction_Homo sapiens_hsa047420.58655639
118GABAergic synapse_Homo sapiens_hsa047270.58584865
119Rap1 signaling pathway_Homo sapiens_hsa040150.58468212
120Calcium signaling pathway_Homo sapiens_hsa040200.57010356
121Graft-versus-host disease_Homo sapiens_hsa053320.56663215
122Tight junction_Homo sapiens_hsa045300.56193563
123Antigen processing and presentation_Homo sapiens_hsa046120.52080140
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51399927
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50487308
126Cholinergic synapse_Homo sapiens_hsa047250.49699361
127Mineral absorption_Homo sapiens_hsa049780.48816747
128beta-Alanine metabolism_Homo sapiens_hsa004100.48490229
129Chemical carcinogenesis_Homo sapiens_hsa052040.48369194
130ABC transporters_Homo sapiens_hsa020100.47799852
131Purine metabolism_Homo sapiens_hsa002300.47081196
132Arginine and proline metabolism_Homo sapiens_hsa003300.46321988
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.45732582
134Hematopoietic cell lineage_Homo sapiens_hsa046400.45477265
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.45413192
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45002533
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44614088
138Propanoate metabolism_Homo sapiens_hsa006400.44378783
139Hepatitis B_Homo sapiens_hsa051610.43720274
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43061858
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42367789
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41735190
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40747470
144Inositol phosphate metabolism_Homo sapiens_hsa005620.40732760
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.40627923
146Long-term potentiation_Homo sapiens_hsa047200.40291646
147Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39901042
148Adherens junction_Homo sapiens_hsa045200.39530601
149Wnt signaling pathway_Homo sapiens_hsa043100.39392023
150Salivary secretion_Homo sapiens_hsa049700.38787692
151Fatty acid biosynthesis_Homo sapiens_hsa000610.38293471
152Pathways in cancer_Homo sapiens_hsa052000.37735170
153Pancreatic secretion_Homo sapiens_hsa049720.36140724
154Dopaminergic synapse_Homo sapiens_hsa047280.35007994
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34205241
156Mismatch repair_Homo sapiens_hsa034300.32744696
157Circadian entrainment_Homo sapiens_hsa047130.32274268
158Glutathione metabolism_Homo sapiens_hsa004800.32123095
159Phagosome_Homo sapiens_hsa041450.29549171
160Tyrosine metabolism_Homo sapiens_hsa003500.28626898
161Drug metabolism - other enzymes_Homo sapiens_hsa009830.28189491
162Systemic lupus erythematosus_Homo sapiens_hsa053220.27758030
163Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27455989
164Lysosome_Homo sapiens_hsa041420.26595975

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