TBR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)7.23396334
2positive regulation of synaptic transmission, dopaminergic (GO:0032226)6.98312939
3mitochondrion distribution (GO:0048311)6.33054710
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.26944881
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.16534786
6glutamate secretion (GO:0014047)6.10284374
7pyrimidine nucleobase catabolic process (GO:0006208)6.08173850
8synaptic vesicle maturation (GO:0016188)6.06914538
9synaptic vesicle exocytosis (GO:0016079)6.00779883
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.99376235
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.92707350
12vocalization behavior (GO:0071625)5.85506947
13locomotory exploration behavior (GO:0035641)5.71565018
14regulation of synaptic vesicle exocytosis (GO:2000300)5.55300252
15establishment of mitochondrion localization, microtubule-mediated (GO:0034643)5.50564332
16mitochondrion transport along microtubule (GO:0047497)5.50564332
17protein localization to synapse (GO:0035418)5.45862957
18establishment of mitochondrion localization (GO:0051654)5.44201703
19regulation of glutamate receptor signaling pathway (GO:1900449)5.37217872
20regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)5.36606305
21regulation of dopamine uptake involved in synaptic transmission (GO:0051584)5.36606305
22behavioral response to ethanol (GO:0048149)5.24911265
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.09716772
24neuron cell-cell adhesion (GO:0007158)5.03357646
25regulation of synaptic vesicle transport (GO:1902803)4.90515125
26nucleobase catabolic process (GO:0046113)4.89950840
27layer formation in cerebral cortex (GO:0021819)4.81378610
28regulation of penile erection (GO:0060405)4.76557237
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.75306073
30ionotropic glutamate receptor signaling pathway (GO:0035235)4.74613378
31mitochondrion localization (GO:0051646)4.71569086
32neuronal action potential propagation (GO:0019227)4.64594595
33positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.62072248
34neurotransmitter-gated ion channel clustering (GO:0072578)4.59988930
35behavioral response to cocaine (GO:0048148)4.57514573
36exploration behavior (GO:0035640)4.57339107
37regulation of long-term neuronal synaptic plasticity (GO:0048169)4.51591021
38chemosensory behavior (GO:0007635)4.49987220
39regulation of neuronal synaptic plasticity (GO:0048168)4.48034724
40synaptic transmission, glutamatergic (GO:0035249)4.41175128
41glutamate receptor signaling pathway (GO:0007215)4.38631705
42adaptation of signaling pathway (GO:0023058)4.35501464
43dendritic spine morphogenesis (GO:0060997)4.26787280
44positive regulation of synapse maturation (GO:0090129)4.23150096
45presynaptic membrane assembly (GO:0097105)4.23129591
46neurotransmitter secretion (GO:0007269)4.16881886
47behavioral response to nicotine (GO:0035095)4.15495503
48regulation of neurotransmitter uptake (GO:0051580)4.11253438
49postsynaptic membrane organization (GO:0001941)4.08761265
50neuron-neuron synaptic transmission (GO:0007270)4.07793024
51positive regulation of membrane potential (GO:0045838)4.06133678
52synaptic transmission, dopaminergic (GO:0001963)4.05963088
53regulation of excitatory postsynaptic membrane potential (GO:0060079)4.05401654
54regulation of synapse structural plasticity (GO:0051823)4.04037798
55proline transport (GO:0015824)4.03527613
56positive regulation of sodium ion transmembrane transport (GO:1902307)4.03139179
57neuron recognition (GO:0008038)3.99431062
58positive regulation of neurotransmitter secretion (GO:0001956)3.97574658
59prenylation (GO:0097354)3.96768846
60protein prenylation (GO:0018342)3.96768846
61regulation of dendritic spine morphogenesis (GO:0061001)3.96594530
62regulation of neurotransmitter secretion (GO:0046928)3.90600801
63presynaptic membrane organization (GO:0097090)3.88586028
64regulation of synaptic plasticity (GO:0048167)3.86191739
65axonal fasciculation (GO:0007413)3.85597764
66regulation of postsynaptic membrane potential (GO:0060078)3.83959484
67neuronal ion channel clustering (GO:0045161)3.83361464
68long-term memory (GO:0007616)3.78964239
69synaptic vesicle endocytosis (GO:0048488)3.78585333
70negative regulation of synaptic transmission, GABAergic (GO:0032229)3.74421545
71long-term synaptic potentiation (GO:0060291)3.73626063
72gamma-aminobutyric acid transport (GO:0015812)3.69156327
73cell proliferation in forebrain (GO:0021846)3.66947348
74G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.65038607
75gamma-aminobutyric acid signaling pathway (GO:0007214)3.63073401
76regulation of dendritic spine development (GO:0060998)3.62264538
77central nervous system projection neuron axonogenesis (GO:0021952)3.53332283
78axon extension (GO:0048675)3.50710475
79positive regulation of RNA splicing (GO:0033120)3.45907948
80dendrite morphogenesis (GO:0048813)3.44386886
81cerebellar granule cell differentiation (GO:0021707)3.44079958
82regulation of synaptic transmission, glutamatergic (GO:0051966)3.44070233
83regulation of synapse maturation (GO:0090128)3.44049859
84regulation of neurotransmitter transport (GO:0051588)3.43454304
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.42314772
86fear response (GO:0042596)3.40865657
87neurofilament cytoskeleton organization (GO:0060052)3.40664903
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40440169
89positive regulation of oligodendrocyte differentiation (GO:0048714)3.39837704
90positive regulation of neurotransmitter transport (GO:0051590)3.37545003
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36382857
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.32540285
93neurotransmitter transport (GO:0006836)3.32279471
94regulation of synaptic transmission, dopaminergic (GO:0032225)3.32246787
95negative regulation of cAMP biosynthetic process (GO:0030818)3.32198917
96positive regulation of amine transport (GO:0051954)3.30909661
97hippocampus development (GO:0021766)3.30783668
98regulation of vesicle fusion (GO:0031338)3.30022209
99L-amino acid import (GO:0043092)3.26367157
100positive regulation of dendritic spine development (GO:0060999)3.25768134
101dopamine receptor signaling pathway (GO:0007212)3.24099277
102adult walking behavior (GO:0007628)3.23904591
103cellular potassium ion homeostasis (GO:0030007)3.22226715
104cell migration in hindbrain (GO:0021535)3.20777503
105organelle transport along microtubule (GO:0072384)3.19803931
106negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)3.19411694
107positive regulation of dendritic spine morphogenesis (GO:0061003)3.18583987
108activation of protein kinase A activity (GO:0034199)3.17805839
109negative regulation of cAMP metabolic process (GO:0030815)3.17280981
110auditory behavior (GO:0031223)3.16368539
111response to amphetamine (GO:0001975)3.15486062
112cerebral cortex radially oriented cell migration (GO:0021799)3.15153100
113dendritic spine organization (GO:0097061)3.14409809
114regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13483801
115regulation of synaptic transmission (GO:0050804)3.11958177
116membrane depolarization (GO:0051899)3.11838923
117learning (GO:0007612)3.10754417
118negative regulation of dendrite development (GO:2000171)3.10358849
119icosanoid secretion (GO:0032309)3.09712612
120arachidonic acid secretion (GO:0050482)3.09712612
121negative regulation of nucleotide biosynthetic process (GO:0030809)3.08988359
122negative regulation of purine nucleotide biosynthetic process (GO:1900372)3.08988359
123response to auditory stimulus (GO:0010996)3.08815656
124positive regulation of synaptic transmission (GO:0050806)3.08456979
125response to histamine (GO:0034776)3.08388368
126long term synaptic depression (GO:0060292)3.07820769
127retina development in camera-type eye (GO:0060041)3.07290076
128cerebellar Purkinje cell differentiation (GO:0021702)3.07171452
129negative regulation of cyclic nucleotide metabolic process (GO:0030800)3.06016033
130regulation of feeding behavior (GO:0060259)3.05786122
131transmission of nerve impulse (GO:0019226)3.04713546
132negative regulation of adenylate cyclase activity (GO:0007194)3.02263311
133neuromuscular process controlling balance (GO:0050885)3.02225260
134regulation of neurotransmitter levels (GO:0001505)3.01956819
135synapse assembly (GO:0007416)3.00886439
136neuron projection extension (GO:1990138)2.98545452
137negative regulation of cation channel activity (GO:2001258)2.97334227
138regulation of collateral sprouting (GO:0048670)2.96276167
139behavioral defense response (GO:0002209)2.95526973
140behavioral fear response (GO:0001662)2.95526973
141positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93126079
142membrane depolarization during action potential (GO:0086010)2.92296139
143synaptic transmission (GO:0007268)2.91215241
144negative regulation of response to food (GO:0032096)2.90933692
145negative regulation of appetite (GO:0032099)2.90933692
146innervation (GO:0060384)2.90689597
147synaptic vesicle transport (GO:0048489)2.89753602
148establishment of synaptic vesicle localization (GO:0097480)2.89753602
149vesicle transport along microtubule (GO:0047496)2.89173107
150regulation of voltage-gated calcium channel activity (GO:1901385)2.89119858
151membrane hyperpolarization (GO:0060081)2.87991160
152positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.87794031
153negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.87473337
154negative regulation of calcium ion transmembrane transport (GO:1903170)2.87473337
155regulation of catecholamine metabolic process (GO:0042069)2.87300979
156regulation of dopamine metabolic process (GO:0042053)2.87300979
157negative regulation of cyclase activity (GO:0031280)2.86460997
158negative regulation of axon guidance (GO:1902668)2.86027421
159mechanosensory behavior (GO:0007638)2.85887323
160synapse organization (GO:0050808)2.83914822
161regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.79951602
162RNA destabilization (GO:0050779)2.78791712
163negative regulation of lyase activity (GO:0051350)2.76053607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.25571426
2GBX2_23144817_ChIP-Seq_PC3_Human3.80226277
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17103560
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09094405
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95429104
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89195358
7REST_21632747_ChIP-Seq_MESCs_Mouse2.69115578
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64854168
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64854168
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63211080
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56551359
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54774374
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.52708054
14DROSHA_22980978_ChIP-Seq_HELA_Human2.43531996
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42386856
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41127267
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39743108
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.39539394
19* EED_16625203_ChIP-ChIP_MESCs_Mouse2.30559249
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20876115
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.20589769
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.18517234
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13136824
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.04896898
25AR_21572438_ChIP-Seq_LNCaP_Human2.04065525
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96559263
27TAF15_26573619_Chip-Seq_HEK293_Human1.91416886
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83230669
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82229609
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81813168
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79692265
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78970159
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77621709
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76608567
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76603178
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.76144731
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75958801
38SMAD4_21799915_ChIP-Seq_A2780_Human1.65377150
39P300_19829295_ChIP-Seq_ESCs_Human1.58489282
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57057305
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56244395
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54466092
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.45176496
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.40461538
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38887472
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38838251
47* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35652377
48AR_25329375_ChIP-Seq_VCAP_Human1.35515055
49* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35410576
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34187473
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.32104909
52IRF1_19129219_ChIP-ChIP_H3396_Human1.31912419
53FUS_26573619_Chip-Seq_HEK293_Human1.30631374
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.30419029
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.28924139
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28395715
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28307923
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27798371
59ZNF274_21170338_ChIP-Seq_K562_Hela1.26222623
60* TP53_20018659_ChIP-ChIP_R1E_Mouse1.24009360
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23378385
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23264089
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23007086
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.22346051
65STAT3_23295773_ChIP-Seq_U87_Human1.20247508
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19733883
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19692751
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19582800
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19246090
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18496607
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17198755
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16873349
73IGF1R_20145208_ChIP-Seq_DFB_Human1.16159393
74AR_19668381_ChIP-Seq_PC3_Human1.15802349
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.14629041
76* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14185473
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14137991
78RNF2_27304074_Chip-Seq_NSC_Mouse1.14132381
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13754840
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13754840
81TP53_16413492_ChIP-PET_HCT116_Human1.13021884
82* RING1B_27294783_Chip-Seq_NPCs_Mouse1.12293267
83TCF4_23295773_ChIP-Seq_U87_Human1.11845758
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11495341
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10291014
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09836479
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09215997
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08700918
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08438648
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.08296884
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.07876528
92TP53_18474530_ChIP-ChIP_U2OS_Human1.05879293
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05008629
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04082047
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03782420
96CTCF_27219007_Chip-Seq_Bcells_Human1.03445951
97* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03286415
98AHR_22903824_ChIP-Seq_MCF-7_Human1.01340372
99* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01338068
100* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01113769
101RUNX2_22187159_ChIP-Seq_PCA_Human0.99744095
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99676648
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99087131
104RXR_22108803_ChIP-Seq_LS180_Human0.99058208
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98265817
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97439654
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97247830
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96835930
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96717338
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96563311
111JUN_21703547_ChIP-Seq_K562_Human0.95851782
112VDR_22108803_ChIP-Seq_LS180_Human0.95277466
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.93726992
114* E2F1_18555785_Chip-Seq_ESCs_Mouse0.92810310
115ER_23166858_ChIP-Seq_MCF-7_Human0.92777025
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.92629059
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90920565
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90893285
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.90334748
120* TAL1_26923725_Chip-Seq_HPCs_Mouse0.89424207
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89102138
122WDR5_24793694_ChIP-Seq_LNCAP_Human0.88785216
123KDM2B_26808549_Chip-Seq_K562_Human0.85810233
124CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83362485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.09391755
2MP0003880_abnormal_central_pattern4.98721136
3MP0003635_abnormal_synaptic_transmissio4.32745088
4MP0004270_analgesia4.07711199
5MP0002063_abnormal_learning/memory/cond3.57085062
6MP0009745_abnormal_behavioral_response3.49671371
7MP0001968_abnormal_touch/_nociception3.24351088
8MP0002064_seizures3.23012162
9MP0005423_abnormal_somatic_nervous3.05546453
10MP0009046_muscle_twitch2.96200778
11MP0002572_abnormal_emotion/affect_behav2.95996005
12MP0001486_abnormal_startle_reflex2.78875797
13MP0002734_abnormal_mechanical_nocicepti2.75696668
14MP0002736_abnormal_nociception_after2.61839506
15MP0002638_abnormal_pupillary_reflex2.52163450
16MP0002272_abnormal_nervous_system2.37242083
17MP0009780_abnormal_chondrocyte_physiolo2.34967346
18MP0001440_abnormal_grooming_behavior2.26968169
19MP0000778_abnormal_nervous_system2.24036224
20MP0002735_abnormal_chemical_nociception2.12944853
21MP0001501_abnormal_sleep_pattern2.12383680
22MP0002733_abnormal_thermal_nociception2.03111491
23MP0003879_abnormal_hair_cell1.98334562
24MP0003121_genomic_imprinting1.98310810
25MP0002067_abnormal_sensory_capabilities1.95269813
26MP0001970_abnormal_pain_threshold1.93217629
27MP0004811_abnormal_neuron_physiology1.87419517
28MP0004858_abnormal_nervous_system1.85847823
29MP0005646_abnormal_pituitary_gland1.85549670
30MP0002557_abnormal_social/conspecific_i1.84319858
31MP0005386_behavior/neurological_phenoty1.81004071
32MP0004924_abnormal_behavior1.81004071
33MP0008569_lethality_at_weaning1.79466490
34MP0003123_paternal_imprinting1.79422779
35MP0002184_abnormal_innervation1.75768973
36MP0002822_catalepsy1.72199952
37MP0003890_abnormal_embryonic-extraembry1.67539543
38MP0003329_amyloid_beta_deposits1.66933170
39MP0004133_heterotaxia1.66333583
40MP0002653_abnormal_ependyma_morphology1.65974588
41MP0001984_abnormal_olfaction1.60603246
42MP0008877_abnormal_DNA_methylation1.55500593
43MP0002928_abnormal_bile_duct1.52593762
44MP0003787_abnormal_imprinting1.50581725
45MP0000955_abnormal_spinal_cord1.48314638
46MP0008789_abnormal_olfactory_epithelium1.44668807
47MP0003633_abnormal_nervous_system1.43608073
48MP0001293_anophthalmia1.43171210
49MP0002882_abnormal_neuron_morphology1.41749553
50MP0004885_abnormal_endolymph1.40382546
51MP0002066_abnormal_motor_capabilities/c1.39503282
52MP0002909_abnormal_adrenal_gland1.29702295
53MP0006276_abnormal_autonomic_nervous1.28391639
54MP0000569_abnormal_digit_pigmentation1.24245149
55MP0005645_abnormal_hypothalamus_physiol1.23560568
56MP0003631_nervous_system_phenotype1.22756236
57MP0001502_abnormal_circadian_rhythm1.21698671
58MP0001905_abnormal_dopamine_level1.20341638
59MP0005195_abnormal_posterior_eye1.17817064
60* MP0002152_abnormal_brain_morphology1.15992131
61MP0001188_hyperpigmentation1.14600276
62MP0005084_abnormal_gallbladder_morpholo1.08995487
63MP0002160_abnormal_reproductive_system1.08889836
64MP0000462_abnormal_digestive_system1.08344526
65MP0001348_abnormal_lacrimal_gland1.06338253
66MP0002751_abnormal_autonomic_nervous1.02019028
67MP0004742_abnormal_vestibular_system1.01706485
68MP0003075_altered_response_to0.99562812
69MP0002233_abnormal_nose_morphology0.98445062
70MP0006292_abnormal_olfactory_placode0.97098851
71MP0008874_decreased_physiological_sensi0.92347914
72MP0000631_abnormal_neuroendocrine_gland0.91999083
73MP0004510_myositis0.91194744
74MP0008004_abnormal_stomach_pH0.91189945
75MP0001529_abnormal_vocalization0.90903026
76MP0001963_abnormal_hearing_physiology0.90250700
77MP0008872_abnormal_physiological_respon0.89983413
78* MP0002069_abnormal_eating/drinking_beha0.89527922
79MP0003942_abnormal_urinary_system0.88357964
80MP0005394_taste/olfaction_phenotype0.87279769
81MP0005499_abnormal_olfactory_system0.87279769
82MP0003690_abnormal_glial_cell0.85395455
83MP0010386_abnormal_urinary_bladder0.84262768
84MP0006072_abnormal_retinal_apoptosis0.84039928
85MP0004130_abnormal_muscle_cell0.83551199
86MP0000427_abnormal_hair_cycle0.83076538
87MP0001177_atelectasis0.82132877
88MP0001299_abnormal_eye_distance/0.81853162
89MP0004142_abnormal_muscle_tone0.81779913
90MP0005253_abnormal_eye_physiology0.81703556
91MP0003632_abnormal_nervous_system0.80419042
92MP0000751_myopathy0.79498541
93MP0003646_muscle_fatigue0.79233988
94MP0001485_abnormal_pinna_reflex0.78160532
95MP0001664_abnormal_digestion0.77682415
96MP0005171_absent_coat_pigmentation0.77435330
97MP0004085_abnormal_heartbeat0.77072612
98MP0005551_abnormal_eye_electrophysiolog0.75427491
99MP0002876_abnormal_thyroid_physiology0.75123245
100MP0002229_neurodegeneration0.74581333
101MP0000049_abnormal_middle_ear0.74416498
102MP0001324_abnormal_eye_pigmentation0.74189551
103MP0004043_abnormal_pH_regulation0.72281600
104MP0005391_vision/eye_phenotype0.71227693
105MP0005535_abnormal_body_temperature0.71174650
106MP0002752_abnormal_somatic_nervous0.70942947
107MP0003634_abnormal_glial_cell0.69369373
108MP0001986_abnormal_taste_sensitivity0.69302018
109MP0005187_abnormal_penis_morphology0.68423215
110MP0004484_altered_response_of0.67174337
111MP0000604_amyloidosis0.67055629
112MP0000920_abnormal_myelination0.66835165
113MP0003861_abnormal_nervous_system0.66353698
114MP0002234_abnormal_pharynx_morphology0.66270248
115MP0004215_abnormal_myocardial_fiber0.63733930
116MP0003567_abnormal_fetal_cardiomyocyte0.63635957
117MP0002090_abnormal_vision0.62403148
118MP0003938_abnormal_ear_development0.62062916
119MP0000026_abnormal_inner_ear0.59810672
120MP0008961_abnormal_basal_metabolism0.56627232
121MP0002102_abnormal_ear_morphology0.55348097
122MP0005167_abnormal_blood-brain_barrier0.55091669
123MP0002837_dystrophic_cardiac_calcinosis0.54716207
124MP0004145_abnormal_muscle_electrophysio0.53548159
125* MP0010769_abnormal_survival0.53037364
126MP0003122_maternal_imprinting0.52153836
127* MP0010770_preweaning_lethality0.51133474
128* MP0002082_postnatal_lethality0.51133474
129MP0010234_abnormal_vibrissa_follicle0.50733908
130MP0004233_abnormal_muscle_weight0.50260628
131* MP0010768_mortality/aging0.49724462

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.46078702
2Myokymia (HP:0002411)6.56604513
3Focal seizures (HP:0007359)6.25760258
4Epileptic encephalopathy (HP:0200134)6.00882900
5Visual hallucinations (HP:0002367)5.13112884
6Febrile seizures (HP:0002373)4.76842932
7Atonic seizures (HP:0010819)4.75942279
8Hyperventilation (HP:0002883)4.44799340
9Absence seizures (HP:0002121)4.19721693
10Broad-based gait (HP:0002136)4.19047423
11Progressive cerebellar ataxia (HP:0002073)4.08378181
12Generalized tonic-clonic seizures (HP:0002069)4.03673073
13Poor eye contact (HP:0000817)3.96352628
14Dialeptic seizures (HP:0011146)3.91923421
15Congenital stationary night blindness (HP:0007642)3.54382035
16Impaired vibration sensation in the lower limbs (HP:0002166)3.49717584
17Gaze-evoked nystagmus (HP:0000640)3.47471298
18Amblyopia (HP:0000646)3.46326309
19Shawl scrotum (HP:0000049)3.44818297
20Medial flaring of the eyebrow (HP:0010747)3.41237300
21Impaired social interactions (HP:0000735)3.32595100
22Abnormal social behavior (HP:0012433)3.32595100
23Nephrogenic diabetes insipidus (HP:0009806)3.29395800
24Pachygyria (HP:0001302)3.27809147
25Papilledema (HP:0001085)3.23724605
26Action tremor (HP:0002345)3.23498175
27Retinal atrophy (HP:0001105)3.16871219
28Drooling (HP:0002307)3.15341397
29Excessive salivation (HP:0003781)3.15341397
30Congenital primary aphakia (HP:0007707)3.11348532
31Esotropia (HP:0000565)3.10652027
32Urinary bladder sphincter dysfunction (HP:0002839)3.08525120
33Hypoplasia of the brainstem (HP:0002365)3.06485988
34Aplasia/Hypoplasia of the brainstem (HP:0007362)3.06485988
35Supranuclear gaze palsy (HP:0000605)3.04296203
36Ankle clonus (HP:0011448)3.01218332
37Lissencephaly (HP:0001339)3.01069602
38Abnormal pancreas size (HP:0012094)3.00057270
39Mutism (HP:0002300)2.96212064
40Depression (HP:0000716)2.91911543
41Stereotypic behavior (HP:0000733)2.91482280
42Inability to walk (HP:0002540)2.88019196
43Absent speech (HP:0001344)2.86210851
44Epileptiform EEG discharges (HP:0011182)2.83608585
45Dysdiadochokinesis (HP:0002075)2.82851464
46Hemiparesis (HP:0001269)2.81284060
47Dysmetria (HP:0001310)2.80590570
48Postural instability (HP:0002172)2.79358790
49Abnormality of binocular vision (HP:0011514)2.79075450
50Diplopia (HP:0000651)2.79075450
51Nephronophthisis (HP:0000090)2.76341122
52Truncal ataxia (HP:0002078)2.75870801
53Abnormal eating behavior (HP:0100738)2.75034032
54Severe muscular hypotonia (HP:0006829)2.71300747
55Genetic anticipation (HP:0003743)2.70577964
56Agitation (HP:0000713)2.69860848
57Obstructive sleep apnea (HP:0002870)2.69283522
58EEG with generalized epileptiform discharges (HP:0011198)2.68082472
59Spastic tetraplegia (HP:0002510)2.68015505
60Urinary urgency (HP:0000012)2.65666314
61Megalencephaly (HP:0001355)2.64541703
62Anxiety (HP:0000739)2.64249827
63Vaginal atresia (HP:0000148)2.63271062
64Abnormal rod and cone electroretinograms (HP:0008323)2.61834897
65Genital tract atresia (HP:0001827)2.60580446
66Insidious onset (HP:0003587)2.56146636
67Termporal pattern (HP:0011008)2.56146636
68Progressive inability to walk (HP:0002505)2.56098988
69Impaired smooth pursuit (HP:0007772)2.53578291
70Hypsarrhythmia (HP:0002521)2.52897663
71Abnormality of midbrain morphology (HP:0002418)2.51823095
72Molar tooth sign on MRI (HP:0002419)2.51823095
73Polymicrogyria (HP:0002126)2.50698074
74Tongue fasciculations (HP:0001308)2.50023820
75Inappropriate behavior (HP:0000719)2.49351338
76Fetal akinesia sequence (HP:0001989)2.49275242
77Pancreatic fibrosis (HP:0100732)2.49142930
78Cerebral inclusion bodies (HP:0100314)2.45842147
79Rib fusion (HP:0000902)2.45464186
80Torticollis (HP:0000473)2.41765783
81Poor coordination (HP:0002370)2.41721496
82Impaired vibratory sensation (HP:0002495)2.40801296
83Protruding tongue (HP:0010808)2.38982922
84Abnormality of the corticospinal tract (HP:0002492)2.38920783
85Spastic gait (HP:0002064)2.35620903
86Bradykinesia (HP:0002067)2.32903861
87Focal dystonia (HP:0004373)2.32819645
88Hypoplasia of the corpus callosum (HP:0002079)2.32479612
89Scanning speech (HP:0002168)2.30333162
90Neurofibrillary tangles (HP:0002185)2.29230521
91Abnormality of the lower motor neuron (HP:0002366)2.28610143
92Blue irides (HP:0000635)2.26540793
93Generalized myoclonic seizures (HP:0002123)2.26226414
94True hermaphroditism (HP:0010459)2.23068664
95Status epilepticus (HP:0002133)2.23007697
96Abnormality of the renal medulla (HP:0100957)2.22613222
97Submucous cleft hard palate (HP:0000176)2.22408201
98Chronic hepatic failure (HP:0100626)2.21844799
99Tented upper lip vermilion (HP:0010804)2.20945305
100Cortical dysplasia (HP:0002539)2.20597089
101Abnormality of salivation (HP:0100755)2.20030967
102Exotropia (HP:0000577)2.19926616
103Retinal dysplasia (HP:0007973)2.19560066
104Polyphagia (HP:0002591)2.18204388
105Incomplete penetrance (HP:0003829)2.17275816
106Myotonia (HP:0002486)2.16695540
107CNS hypomyelination (HP:0003429)2.15170829
108Dysmetric saccades (HP:0000641)2.12084024
109Poor suck (HP:0002033)2.11672787
110Abnormality of ocular smooth pursuit (HP:0000617)2.11550543
111Abnormal respiratory epithelium morphology (HP:0012253)2.10360595
112Abnormal respiratory motile cilium morphology (HP:0005938)2.10360595
113Intellectual disability, moderate (HP:0002342)2.10202292
114Lower limb muscle weakness (HP:0007340)2.10032306
115Hemiplegia (HP:0002301)2.09174533
116Muscle fibrillation (HP:0010546)2.06987337
117Pancreatic cysts (HP:0001737)2.04611757
118Amyotrophic lateral sclerosis (HP:0007354)2.03250387
119Akinesia (HP:0002304)2.02182605
120Abnormal ciliary motility (HP:0012262)2.01636510
121Tubulointerstitial fibrosis (HP:0005576)1.99848542
122Absent/shortened dynein arms (HP:0200106)1.99613017
123Dynein arm defect of respiratory motile cilia (HP:0012255)1.99613017
124Generalized hypopigmentation of hair (HP:0011358)1.98910356
125Apathy (HP:0000741)1.98504517
126Gait imbalance (HP:0002141)1.98459438
127Left ventricular hypertrophy (HP:0001712)1.97320868
128Intention tremor (HP:0002080)1.96567335
129Morphological abnormality of the pyramidal tract (HP:0002062)1.96455758
130Failure to thrive in infancy (HP:0001531)1.95948208
131Lower limb amyotrophy (HP:0007210)1.93906297
132Craniofacial dystonia (HP:0012179)1.93849521
133Specific learning disability (HP:0001328)1.91965465
134Limb dystonia (HP:0002451)1.89915731
135Aqueductal stenosis (HP:0002410)1.88053050
136Tubular atrophy (HP:0000092)1.87725810
137Sleep apnea (HP:0010535)1.85578125
138Gait ataxia (HP:0002066)1.83201085
139Widely spaced teeth (HP:0000687)1.83161244
140Gastroesophageal reflux (HP:0002020)1.82816810
141Aplasia involving bones of the upper limbs (HP:0009823)1.82034463
142Aplasia of the phalanges of the hand (HP:0009802)1.82034463
143Aplasia involving bones of the extremities (HP:0009825)1.82034463
144Thickened helices (HP:0000391)1.80326134
145Intellectual disability, profound (HP:0002187)1.80324224
146Annular pancreas (HP:0001734)1.79142224
147Intellectual disability, severe (HP:0010864)1.78403621
148Dyskinesia (HP:0100660)1.76239148
149Deeply set eye (HP:0000490)1.75599193
150Delusions (HP:0000746)1.75421656
151Pointed chin (HP:0000307)1.72825728

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.82679824
2MARK14.01342350
3NTRK33.78315717
4MAP3K93.52563669
5DAPK23.17972223
6MAP3K43.02464260
7MAP2K73.00430765
8CASK2.56828741
9RIPK42.45258857
10MINK12.36897492
11PAK62.34494973
12CDK192.32667345
13MAP3K122.11484543
14DAPK12.00976042
15PLK21.92961158
16MAP2K41.86276575
17SIK21.84638210
18NTRK21.83587510
19PRKD31.77423271
20CAMKK11.71896187
21MAPK131.70639214
22CCNB11.70299533
23TNIK1.69592271
24KSR11.66389158
25EPHA31.65631517
26PRPF4B1.58152388
27CDK51.55036313
28KSR21.49430563
29BCR1.38765535
30GRK51.22156451
31FRK1.20116574
32PRKCG1.18109491
33NTRK11.13624784
34OXSR11.13320402
35BMPR21.11741682
36BMPR1B1.11681518
37LATS21.09331320
38DYRK31.05721573
39UHMK11.04166414
40PRKAA10.99024719
41CAMKK20.98681156
42MAP3K130.97823497
43TAOK10.94785199
44TRIM280.93822154
45STK380.93224211
46CDK180.92902323
47CAMK10.92014990
48STK110.91553177
49CAMK2A0.90478082
50CDK150.90001125
51SIK30.89436823
52GRK10.89309317
53DYRK1A0.88477599
54TYRO30.87346307
55PHKG10.86356445
56PHKG20.86356445
57PTK2B0.85442084
58SGK20.84178400
59SGK4940.83709282
60SGK2230.83709282
61FES0.82539456
62PNCK0.82396331
63CDK140.81376517
64CAMK1D0.80951926
65MAP4K20.79841721
66ARAF0.79606744
67CDK11A0.79158159
68CSNK1G20.77074906
69RPS6KA50.76486757
70RPS6KA20.76425347
71DYRK1B0.72921439
72MAP3K20.72164182
73CSNK1G30.71814526
74FGR0.69477955
75SGK10.69005323
76WNK40.68133667
77PDK10.67980760
78MARK20.67954411
79CSNK1A1L0.66639040
80MAPK120.66041722
81ABL20.65767107
82MAP3K60.65139561
83SGK30.64817715
84PDPK10.64047611
85RET0.62858834
86PRKCH0.62122736
87RAF10.61924876
88PAK30.57766544
89CAMK2B0.57045612
90CSNK1G10.56560104
91TAOK20.53072088
92DAPK30.52724844
93ALK0.51514006
94ERBB30.50254708
95CSNK1E0.50243021
96EEF2K0.49680230
97CAMK40.49154867
98PRKCZ0.48081824
99PRKCE0.47938842
100PINK10.44407795
101AKT30.44071390
102EPHB10.42775552
103CDK80.42562558
104CSNK1A10.42303993
105ILK0.41822220
106PRKG10.41732525
107RPS6KA30.39554224
108MAPK70.39306861
109MAPKAPK30.39150775
110NEK60.38932217
111FYN0.37214468
112ZAK0.36882845
113PKN10.36837836
114MAPK90.36391957
115STK160.35994348
116PRKACA0.35766930
117MAP3K50.35595389
118MUSK0.35322007
119EPHB20.33798469
120ADRBK20.33340536
121MAP2K60.32514124
122CDK30.31880684
123WNK30.31060844
124PRKCI0.30656190
125MAP3K70.29957689
126CAMK1G0.28512968
127MAP3K10.28041437
128NME10.27832509
129MAP2K10.27750058
130CSNK1D0.27685096
131MAPKAPK50.27648419
132PRKDC0.27490889
133DYRK20.27144507
134PRKCA0.26768424
135DMPK0.25662529
136PRKCB0.24822108
137PRKCD0.24290630
138TIE10.24073391

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.65665589
2Synaptic vesicle cycle_Homo sapiens_hsa047213.43329727
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.01529964
4Circadian entrainment_Homo sapiens_hsa047132.75183485
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72308360
6Olfactory transduction_Homo sapiens_hsa047402.69283793
7Glutamatergic synapse_Homo sapiens_hsa047242.67641869
8Long-term potentiation_Homo sapiens_hsa047202.62579565
9Morphine addiction_Homo sapiens_hsa050322.54667522
10GABAergic synapse_Homo sapiens_hsa047272.46859155
11Amphetamine addiction_Homo sapiens_hsa050312.40641239
12Salivary secretion_Homo sapiens_hsa049702.24055885
13Dopaminergic synapse_Homo sapiens_hsa047282.09498683
14Insulin secretion_Homo sapiens_hsa049112.02343587
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97147303
16Gastric acid secretion_Homo sapiens_hsa049711.92750908
17Cholinergic synapse_Homo sapiens_hsa047251.91043660
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81409896
19Oxytocin signaling pathway_Homo sapiens_hsa049211.74729668
20Renin secretion_Homo sapiens_hsa049241.74001139
21Taste transduction_Homo sapiens_hsa047421.73621668
22Long-term depression_Homo sapiens_hsa047301.66582179
23Serotonergic synapse_Homo sapiens_hsa047261.65585599
24Calcium signaling pathway_Homo sapiens_hsa040201.61406621
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60653455
26Collecting duct acid secretion_Homo sapiens_hsa049661.59698834
27Bile secretion_Homo sapiens_hsa049761.48424273
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46755488
29GnRH signaling pathway_Homo sapiens_hsa049121.42139131
30Axon guidance_Homo sapiens_hsa043601.41146262
31Cocaine addiction_Homo sapiens_hsa050301.36516852
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36494178
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36345044
34Oxidative phosphorylation_Homo sapiens_hsa001901.34547037
35Gap junction_Homo sapiens_hsa045401.30420551
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30245465
37cAMP signaling pathway_Homo sapiens_hsa040241.27616693
38Parkinsons disease_Homo sapiens_hsa050121.24397087
39ErbB signaling pathway_Homo sapiens_hsa040121.22193501
40Glioma_Homo sapiens_hsa052141.21975084
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20016598
42Type II diabetes mellitus_Homo sapiens_hsa049301.17038030
43Estrogen signaling pathway_Homo sapiens_hsa049151.12447696
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11632573
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10765859
46Melanogenesis_Homo sapiens_hsa049161.09533383
47Steroid biosynthesis_Homo sapiens_hsa001001.08172056
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04568181
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03481067
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01592454
51Fatty acid biosynthesis_Homo sapiens_hsa000610.98082682
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96991875
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96477213
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94577468
55Regulation of autophagy_Homo sapiens_hsa041400.92090433
56Alzheimers disease_Homo sapiens_hsa050100.89570545
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.86698540
58Vibrio cholerae infection_Homo sapiens_hsa051100.85183404
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81521893
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80619303
61MAPK signaling pathway_Homo sapiens_hsa040100.79332572
62Dorso-ventral axis formation_Homo sapiens_hsa043200.78827828
63Cardiac muscle contraction_Homo sapiens_hsa042600.76347129
64Oocyte meiosis_Homo sapiens_hsa041140.76177720
65Choline metabolism in cancer_Homo sapiens_hsa052310.75976503
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.74757675
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74592183
68Pancreatic secretion_Homo sapiens_hsa049720.74185777
69VEGF signaling pathway_Homo sapiens_hsa043700.73199993
70African trypanosomiasis_Homo sapiens_hsa051430.71643031
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70671404
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70629103
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70527216
74Ras signaling pathway_Homo sapiens_hsa040140.69249485
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.68258760
76Fatty acid metabolism_Homo sapiens_hsa012120.68169992
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.67866652
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66962977
79Butanoate metabolism_Homo sapiens_hsa006500.64805753
80Phototransduction_Homo sapiens_hsa047440.64513152
81Wnt signaling pathway_Homo sapiens_hsa043100.63251007
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62678769
83Dilated cardiomyopathy_Homo sapiens_hsa054140.62424204
84Huntingtons disease_Homo sapiens_hsa050160.62276983
85Circadian rhythm_Homo sapiens_hsa047100.61026032
86Rap1 signaling pathway_Homo sapiens_hsa040150.60814606
87Endometrial cancer_Homo sapiens_hsa052130.59359293
88Thyroid hormone synthesis_Homo sapiens_hsa049180.58589792
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57898037
90Sulfur relay system_Homo sapiens_hsa041220.56831703
91Nitrogen metabolism_Homo sapiens_hsa009100.56505766
92Hippo signaling pathway_Homo sapiens_hsa043900.56229716
93mTOR signaling pathway_Homo sapiens_hsa041500.52697403
94Glucagon signaling pathway_Homo sapiens_hsa049220.51865494
95Hedgehog signaling pathway_Homo sapiens_hsa043400.51861948
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51225276
97Renal cell carcinoma_Homo sapiens_hsa052110.50505125
98Peroxisome_Homo sapiens_hsa041460.50117956
99Non-small cell lung cancer_Homo sapiens_hsa052230.46205394
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45742183
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.44583909
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44114532
103Colorectal cancer_Homo sapiens_hsa052100.44033638
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43576592
105Inositol phosphate metabolism_Homo sapiens_hsa005620.43406535
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42944064
107Endocytosis_Homo sapiens_hsa041440.42462258
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42176171
109Chemokine signaling pathway_Homo sapiens_hsa040620.41950760
110Ether lipid metabolism_Homo sapiens_hsa005650.41185575
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40377444
112ABC transporters_Homo sapiens_hsa020100.40307991
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39037563
114AMPK signaling pathway_Homo sapiens_hsa041520.38449704
115Type I diabetes mellitus_Homo sapiens_hsa049400.37685189
116Rheumatoid arthritis_Homo sapiens_hsa053230.36247709
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36137550
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35695123
119Prion diseases_Homo sapiens_hsa050200.35141627
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34680733
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34564815
122Insulin signaling pathway_Homo sapiens_hsa049100.33357336
123Alcoholism_Homo sapiens_hsa050340.32747138
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32680430
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32534959
126Ovarian steroidogenesis_Homo sapiens_hsa049130.29953573
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27861023

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