TBRG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.26841872
2positive regulation of gamma-delta T cell activation (GO:0046645)4.98290801
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80750428
4negative regulation of cell killing (GO:0031342)4.71747142
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.71747142
6formation of translation preinitiation complex (GO:0001731)4.71422142
7ribosomal small subunit assembly (GO:0000028)4.53612410
8negative T cell selection (GO:0043383)4.43685909
9negative thymic T cell selection (GO:0045060)4.29040691
10cellular response to interleukin-15 (GO:0071350)4.12015519
11positive thymic T cell selection (GO:0045059)4.11289247
12positive T cell selection (GO:0043368)4.06383400
13nucleobase biosynthetic process (GO:0046112)4.02435131
14regulation of B cell receptor signaling pathway (GO:0050855)4.00738153
15purine nucleobase biosynthetic process (GO:0009113)3.96866619
16regulation of gamma-delta T cell differentiation (GO:0045586)3.93642197
17maturation of SSU-rRNA (GO:0030490)3.93104187
18COPI coating of Golgi vesicle (GO:0048205)3.83728743
19Golgi transport vesicle coating (GO:0048200)3.83728743
20regulation of gamma-delta T cell activation (GO:0046643)3.81928919
21response to interleukin-15 (GO:0070672)3.75371828
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64151089
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.54453377
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.53640786
25T cell selection (GO:0045058)3.49271473
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48713527
27activated T cell proliferation (GO:0050798)3.43058251
28protein targeting to ER (GO:0045047)3.42847032
29cytidine metabolic process (GO:0046087)3.42653104
30cytidine catabolic process (GO:0006216)3.42653104
31cytidine deamination (GO:0009972)3.42653104
32cotranslational protein targeting to membrane (GO:0006613)3.42327382
33ribosomal small subunit biogenesis (GO:0042274)3.41241830
34anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.40454140
35antigen processing and presentation of endogenous antigen (GO:0019883)3.39180260
36pyrimidine ribonucleoside catabolic process (GO:0046133)3.37746222
37ribosome assembly (GO:0042255)3.36743093
38negative regulation of ligase activity (GO:0051352)3.35912711
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.35912711
40ribosomal large subunit biogenesis (GO:0042273)3.35552489
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.34991841
42viral transcription (GO:0019083)3.33580854
43translational termination (GO:0006415)3.33230886
44positive regulation of granulocyte differentiation (GO:0030854)3.31906707
45DNA strand elongation involved in DNA replication (GO:0006271)3.31327324
46thymic T cell selection (GO:0045061)3.30085098
47proteasome assembly (GO:0043248)3.29724215
48ribosome biogenesis (GO:0042254)3.28068280
49ribonucleoprotein complex biogenesis (GO:0022613)3.27687242
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26168971
51protein localization to endoplasmic reticulum (GO:0070972)3.26052843
52translational initiation (GO:0006413)3.24945803
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.23683343
54regulation of T cell receptor signaling pathway (GO:0050856)3.21434055
55establishment of protein localization to endoplasmic reticulum (GO:0072599)3.21372873
56DNA strand elongation (GO:0022616)3.21002941
57DNA deamination (GO:0045006)3.20770085
58negative regulation of T cell mediated immunity (GO:0002710)3.20206476
59cullin deneddylation (GO:0010388)3.19585474
60mitotic nuclear envelope disassembly (GO:0007077)3.19311860
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19133538
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19133538
63positive regulation of B cell differentiation (GO:0045579)3.18834971
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.18639392
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.18639392
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.18639392
67immunoglobulin mediated immune response (GO:0016064)3.15719699
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.15389887
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14781675
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.13753488
71signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13753488
72mitotic metaphase plate congression (GO:0007080)3.13041824
73regulation of B cell differentiation (GO:0045577)3.10581472
74translation (GO:0006412)3.10292513
75nuclear pore organization (GO:0006999)3.10033468
76translational elongation (GO:0006414)3.09812730
77IMP biosynthetic process (GO:0006188)3.08931594
78positive regulation of defense response to virus by host (GO:0002230)3.08717816
79signal transduction involved in cell cycle checkpoint (GO:0072395)3.07627688
80antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.07115580
81telomere maintenance via semi-conservative replication (GO:0032201)3.06769534
82Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06177114
83B cell receptor signaling pathway (GO:0050853)3.05879081
84regulation of alpha-beta T cell proliferation (GO:0046640)3.05226497
85folic acid-containing compound biosynthetic process (GO:0009396)3.03977155
86negative regulation of lymphocyte mediated immunity (GO:0002707)3.03180008
87regulation of translation in response to stress (GO:0043555)3.02520158
88protein deneddylation (GO:0000338)3.01545563
89regulation of cellular amino acid metabolic process (GO:0006521)3.00757427
90regulation of regulatory T cell differentiation (GO:0045589)3.00391034
91antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98624629
92mast cell activation (GO:0045576)2.98522804
93positive regulation of ligase activity (GO:0051351)2.97891351
94regulation of T cell tolerance induction (GO:0002664)2.97226226
95GDP-mannose metabolic process (GO:0019673)2.96258702
96antigen receptor-mediated signaling pathway (GO:0050851)2.95373551
97DNA replication initiation (GO:0006270)2.94809304
98rRNA modification (GO:0000154)2.92977123
99nuclear envelope disassembly (GO:0051081)2.91638996
100membrane disassembly (GO:0030397)2.91638996
101maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.90798973
102regulation of T cell mediated cytotoxicity (GO:0001914)2.90310459
103rRNA processing (GO:0006364)2.89268207
104DNA replication checkpoint (GO:0000076)2.88947530
1057-methylguanosine mRNA capping (GO:0006370)2.88287934
106negative regulation of interleukin-1 beta production (GO:0032691)2.87602868
107termination of RNA polymerase III transcription (GO:0006386)2.87082198
108transcription elongation from RNA polymerase III promoter (GO:0006385)2.87082198
109transcription-coupled nucleotide-excision repair (GO:0006283)2.85828372
110T cell receptor signaling pathway (GO:0050852)2.85748236
111positive regulation of cell cycle arrest (GO:0071158)2.81926057
112transcription from RNA polymerase I promoter (GO:0006360)2.81288444
113regulation of ubiquitin-protein transferase activity (GO:0051438)2.80403419
114RNA capping (GO:0036260)2.80170747
1157-methylguanosine RNA capping (GO:0009452)2.80170747
116regulation of germinal center formation (GO:0002634)2.79559489
117cell cycle G1/S phase transition (GO:0044843)2.78663537
118G1/S transition of mitotic cell cycle (GO:0000082)2.78663537
119telomere maintenance via recombination (GO:0000722)2.78460615
120rRNA metabolic process (GO:0016072)2.78449642
121termination of RNA polymerase I transcription (GO:0006363)2.78246135
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.78223866
123negative regulation of interleukin-1 production (GO:0032692)2.77768729
124interferon-gamma-mediated signaling pathway (GO:0060333)2.77494556
125negative regulation of interleukin-12 production (GO:0032695)2.76734079
126adaptation of signaling pathway (GO:0023058)2.75896384
127positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75761644
128antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.75489568
129positive regulation of tolerance induction (GO:0002645)2.75269927
130regulation of gene silencing by RNA (GO:0060966)2.75099883
131regulation of posttranscriptional gene silencing (GO:0060147)2.75099883
132regulation of gene silencing by miRNA (GO:0060964)2.75099883
133T cell migration (GO:0072678)2.74698278
134neutrophil activation involved in immune response (GO:0002283)2.74272469
135viral life cycle (GO:0019058)2.73806580
136tolerance induction (GO:0002507)2.72652187
137positive regulation of calcium-mediated signaling (GO:0050850)2.71978883
138telomere maintenance via telomere lengthening (GO:0010833)2.70490297
139regulation of ligase activity (GO:0051340)2.67684193
140protein retention in ER lumen (GO:0006621)2.67662260
141negative regulation of cAMP-mediated signaling (GO:0043951)2.66947164
142regulation of tolerance induction (GO:0002643)2.65739519
143cellular extravasation (GO:0045123)2.65514006
144spliceosomal snRNP assembly (GO:0000387)2.64658684
145regulation of leukocyte mediated cytotoxicity (GO:0001910)2.64605862
146actin nucleation (GO:0045010)2.64224296
147positive regulation of alpha-beta T cell proliferation (GO:0046641)2.64208462
148negative regulation of leukocyte mediated immunity (GO:0002704)2.64064398
149DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.63870421
150regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63636024
151nuclear pore complex assembly (GO:0051292)2.63125009
152regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.63043366
153regulation of natural killer cell mediated immunity (GO:0002715)2.63043366
154positive regulation of T cell differentiation in thymus (GO:0033089)2.63007274
155regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.61515758
156detection of other organism (GO:0098543)2.61398599
157negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.60880337
158detection of bacterium (GO:0016045)2.60848021
159regulation of antigen processing and presentation (GO:0002577)2.60649914
160cellular protein complex disassembly (GO:0043624)2.60590674
161positive regulation of antigen processing and presentation (GO:0002579)2.59684337
162neutrophil activation (GO:0042119)2.58988475
163mast cell activation involved in immune response (GO:0002279)2.58972675
164mast cell degranulation (GO:0043303)2.58972675
165regulation of interleukin-1 beta secretion (GO:0050706)2.58825224
166blastocyst development (GO:0001824)2.58623894
167metaphase plate congression (GO:0051310)2.58284707
168L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57831804
169nucleobase-containing small molecule interconversion (GO:0015949)2.56777926
170viral mRNA export from host cell nucleus (GO:0046784)2.55210016
171DNA replication-dependent nucleosome assembly (GO:0006335)2.54228269
172DNA replication-dependent nucleosome organization (GO:0034723)2.54228269
173transcription initiation from RNA polymerase I promoter (GO:0006361)2.53134942
174negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.52896260
175negative regulation of T-helper cell differentiation (GO:0045623)2.52896260
176positive regulation of interleukin-1 beta secretion (GO:0050718)2.52852946
177cellular component biogenesis (GO:0044085)2.52437324
178cellular response to ethanol (GO:0071361)2.52312108
179tRNA aminoacylation for protein translation (GO:0006418)2.51921214
180antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49947072
181positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.49136697
182positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.47900631
183positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.47789799
184myeloid cell activation involved in immune response (GO:0002275)2.47484792
185leukocyte degranulation (GO:0043299)2.47364910
186negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.46013206
187leukocyte aggregation (GO:0070486)2.45958591
188granulocyte activation (GO:0036230)2.45846549
189regulation of interleukin-2 biosynthetic process (GO:0045076)2.45734194
190regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.44874975
191response to interferon-beta (GO:0035456)2.44380453
192interferon-gamma production (GO:0032609)2.44320409
193regulation of cell killing (GO:0031341)2.43928833
194negative regulation of T cell receptor signaling pathway (GO:0050860)2.41885862
195cellular response to type I interferon (GO:0071357)2.40723383
196type I interferon signaling pathway (GO:0060337)2.40723383
197regulation of mast cell activation (GO:0033003)2.40283225
198negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.39615768
199negative regulation of alpha-beta T cell activation (GO:0046636)2.38766595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.20640768
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.75294329
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.49259813
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.03300574
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.02404073
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57278359
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34681656
8* GABP_17652178_ChIP-ChIP_JURKAT_Human3.23105324
9* IRF8_21731497_ChIP-ChIP_J774_Mouse3.17712479
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.11005502
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09115526
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.97391694
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.88961119
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.85192371
15RUNX_20019798_ChIP-Seq_JUKART_Human2.85033980
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69367996
17* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69314784
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66740716
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.53330571
20* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.44511014
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36914406
22* MYB_26560356_Chip-Seq_TH2_Human2.36694562
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36348460
24* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36234072
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31074802
26ZNF274_21170338_ChIP-Seq_K562_Hela2.25471036
27* IRF8_27001747_Chip-Seq_BMDM_Mouse2.23562054
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23480665
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.18954187
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18029260
31* VDR_23849224_ChIP-Seq_CD4+_Human2.18011842
32XRN2_22483619_ChIP-Seq_HELA_Human2.15795886
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11845280
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11330312
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11310294
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11306463
37FOXM1_23109430_ChIP-Seq_U2OS_Human2.07589040
38GATA1_22025678_ChIP-Seq_K562_Human2.06509556
39* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.06501372
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06138059
41SMAD_19615063_ChIP-ChIP_OVARY_Human2.06058184
42DCP1A_22483619_ChIP-Seq_HELA_Human2.02690897
43* GATA3_26560356_Chip-Seq_TH2_Human2.01257298
44GATA3_27048872_Chip-Seq_THYMUS_Human1.94251966
45* GABP_19822575_ChIP-Seq_HepG2_Human1.92573187
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88726960
47ELK1_19687146_ChIP-ChIP_HELA_Human1.85393215
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.82511194
49FOXP3_21729870_ChIP-Seq_TREG_Human1.80598570
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80525847
51* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73693193
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73139597
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72093806
54* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70072728
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.69212812
56SCL_19346495_ChIP-Seq_HPC-7_Human1.67098544
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65628642
58* SRF_21415370_ChIP-Seq_HL-1_Mouse1.62830192
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62467805
60* TTF2_22483619_ChIP-Seq_HELA_Human1.61703300
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61643570
62VDR_22108803_ChIP-Seq_LS180_Human1.59704606
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.59576179
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58757745
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58212501
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57952257
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56032728
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55912718
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54123725
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53445765
71* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52605445
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52237062
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51166448
74* MYB_26560356_Chip-Seq_TH1_Human1.50484611
75AR_21909140_ChIP-Seq_LNCAP_Human1.50152447
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49971282
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48102121
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47743235
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.42427479
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41409611
81TFEB_21752829_ChIP-Seq_HELA_Human1.40358937
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.39569276
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39403965
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.38764467
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.37239793
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36664241
87* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34715188
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34652544
89MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34014626
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33483567
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32940217
92KDM5A_27292631_Chip-Seq_BREAST_Human1.30420587
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29718948
94SPI1_23127762_ChIP-Seq_K562_Human1.28607932
95* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28117182
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28114934
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27983926
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27115757
99VDR_24787735_ChIP-Seq_THP-1_Human1.25638015
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23204940
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22658171
102* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21239076
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20763716
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20158832
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19261160
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19261160
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19261160
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.19091262
109GBX2_23144817_ChIP-Seq_PC3_Human1.18089482
110RUNX1_22412390_ChIP-Seq_EML_Mouse1.17431223
111* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16973907
112SMRT_27268052_Chip-Seq_Bcells_Human1.14427388
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13661435
114IRF8_22096565_ChIP-ChIP_GC-B_Human1.13351585
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12235783
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11380395
117UTX_26944678_Chip-Seq_JUKART_Human1.10043946
118SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09542364
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09468946
120CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08856891
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08073529
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07574825
123ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07156859
124TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04643978
125CIITA_25753668_ChIP-Seq_RAJI_Human1.02272362
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01776385
127VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00985195
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00635199
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00433086
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00378398
131TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99899501
132NOTCH1_21737748_ChIP-Seq_TLL_Human0.98164653
133MAF_26560356_Chip-Seq_TH1_Human0.98038631
134IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97118208
135MYC_22102868_ChIP-Seq_BL_Human0.96659020
136POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96053909
137* SPI1_23547873_ChIP-Seq_NB4_Human0.95910173
138MAF_26560356_Chip-Seq_TH2_Human0.95484304
139STAT1_20625510_ChIP-Seq_HELA_Human0.95333615
140SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95065873
141TP63_19390658_ChIP-ChIP_HaCaT_Human0.95029898
142* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94738998
143* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94667868
144SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94455658
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94436110
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94352173
147CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94189249
148ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93815060
149* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93746350
150SOX17_20123909_ChIP-Seq_XEN_Mouse0.93311575
151PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92493745
152GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91682548
153E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91540365
154EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90424622
155E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89847166
156CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89383187
157* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89330211
158GATA3_26560356_Chip-Seq_TH1_Human0.87993070
159DROSHA_22980978_ChIP-Seq_HELA_Human0.87380953
160BCAT_22108803_ChIP-Seq_LS180_Human0.87377071
161HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86863972
162CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86715263
163STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86015888
164CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85356427
165GATA1_19941827_ChIP-Seq_MEL_Mouse0.85342644
166TP53_22573176_ChIP-Seq_HFKS_Human0.85268339
167FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84443966
168PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84386889
169VDR_24763502_ChIP-Seq_THP-1_Human0.83798584
170SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81487643
171PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80256682
172GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79735877
173PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79311856
174EZH2_27294783_Chip-Seq_NPCs_Mouse0.79055630
175RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78703297
176GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78693489
177KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.78621596
178EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78455011
179REST_21632747_ChIP-Seq_MESCs_Mouse0.78307628
180CRX_20693478_ChIP-Seq_RETINA_Mouse0.77885555
181NFE2_27457419_Chip-Seq_LIVER_Mouse0.77846716
182TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.77270867
183BCL6_27268052_Chip-Seq_Bcells_Human0.75738614
184ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75157220
185TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.73041587
186CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72487400
187PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72420642

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.19516841
2MP0004957_abnormal_blastocyst_morpholog3.48603912
3MP0003436_decreased_susceptibility_to3.07012957
4MP0001800_abnormal_humoral_immune2.71569613
5MP0005000_abnormal_immune_tolerance2.69037435
6MP0003077_abnormal_cell_cycle2.64048383
7MP0003111_abnormal_nucleus_morphology2.64030477
8MP0010094_abnormal_chromosome_stability2.55428583
9MP0003123_paternal_imprinting2.52255361
10MP0002148_abnormal_hypersensitivity_rea2.47527848
11MP0002723_abnormal_immune_serum2.44093437
12MP0008007_abnormal_cellular_replicative2.39883870
13MP0001790_abnormal_immune_system2.36168852
14MP0005387_immune_system_phenotype2.36168852
15MP0003303_peritoneal_inflammation2.27473167
16MP0002452_abnormal_antigen_presenting2.27169445
17MP0002420_abnormal_adaptive_immunity2.25276001
18MP0005025_abnormal_response_to2.24145861
19MP0001819_abnormal_immune_cell2.23472925
20MP0001986_abnormal_taste_sensitivity2.22761676
21MP0002419_abnormal_innate_immunity2.13926453
22MP0004264_abnormal_extraembryonic_tissu2.13071072
23MP0008438_abnormal_cutaneous_collagen2.01745514
24MP0010352_gastrointestinal_tract_polyps2.01098489
25MP0003806_abnormal_nucleotide_metabolis2.00562013
26MP0003786_premature_aging2.00326015
27MP0008058_abnormal_DNA_repair2.00253700
28MP0006054_spinal_hemorrhage1.98652735
29MP0008932_abnormal_embryonic_tissue1.95986653
30MP0003172_abnormal_lysosome_physiology1.92008048
31MP0001501_abnormal_sleep_pattern1.91135350
32MP0008057_abnormal_DNA_replication1.86319110
33MP0003191_abnormal_cellular_cholesterol1.80819351
34MP0002877_abnormal_melanocyte_morpholog1.78114617
35MP0002166_altered_tumor_susceptibility1.76673679
36MP0005464_abnormal_platelet_physiology1.76267368
37MP0000716_abnormal_immune_system1.73290997
38MP0006082_CNS_inflammation1.70088201
39MP0003566_abnormal_cell_adhesion1.69044925
40MP0001730_embryonic_growth_arrest1.64010781
41MP0010155_abnormal_intestine_physiology1.62908543
42MP0003941_abnormal_skin_development1.61754688
43MP0002405_respiratory_system_inflammati1.56678896
44MP0001533_abnormal_skeleton_physiology1.55436013
45MP0005023_abnormal_wound_healing1.53223998
46MP0001845_abnormal_inflammatory_respons1.53086098
47MP0005503_abnormal_tendon_morphology1.49114678
48MP0003866_abnormal_defecation1.48102881
49MP0003186_abnormal_redox_activity1.47734118
50MP0000350_abnormal_cell_proliferation1.47609998
51MP0000465_gastrointestinal_hemorrhage1.46216188
52MP0003705_abnormal_hypodermis_morpholog1.45560645
53MP0001542_abnormal_bone_strength1.45295340
54MP0000604_amyloidosis1.44602792
55MP0002138_abnormal_hepatobiliary_system1.40338123
56MP0005310_abnormal_salivary_gland1.38025386
57MP0001672_abnormal_embryogenesis/_devel1.35973821
58MP0005380_embryogenesis_phenotype1.35973821
59MP0009764_decreased_sensitivity_to1.35114180
60MP0001697_abnormal_embryo_size1.34034744
61MP0003300_gastrointestinal_ulcer1.33919837
62MP0003880_abnormal_central_pattern1.33080291
63MP0002006_tumorigenesis1.32335833
64MP0003567_abnormal_fetal_cardiomyocyte1.32046819
65MP0003984_embryonic_growth_retardation1.31030408
66MP0003718_maternal_effect1.29482659
67MP0008469_abnormal_protein_level1.28182351
68MP0002088_abnormal_embryonic_growth/wei1.27369693
69MP0005275_abnormal_skin_tensile1.26723880
70MP0004272_abnormal_basement_membrane1.26459057
71MP0009333_abnormal_splenocyte_physiolog1.26413511
72MP0003121_genomic_imprinting1.25201422
73MP0000490_abnormal_crypts_of1.25122353
74MP0002086_abnormal_extraembryonic_tissu1.23336928
75MP0004197_abnormal_fetal_growth/weight/1.22145004
76MP0002080_prenatal_lethality1.20752431
77MP0002102_abnormal_ear_morphology1.20613049
78MP0004947_skin_inflammation1.19582005
79MP0004147_increased_porphyrin_level1.17781355
80MP0000703_abnormal_thymus_morphology1.17560062
81MP0009745_abnormal_behavioral_response1.15150404
82MP0003119_abnormal_digestive_system1.13374246
83MP0001968_abnormal_touch/_nociception1.11937912
84MP0000858_altered_metastatic_potential1.10668956
85MP0002009_preneoplasia1.10171382
86MP0010030_abnormal_orbit_morphology1.09891935
87MP0003075_altered_response_to1.08129346
88MP0010307_abnormal_tumor_latency1.07969280
89MP0003690_abnormal_glial_cell1.06993157
90MP0001853_heart_inflammation1.05478708
91MP0002064_seizures1.05273110
92MP0009278_abnormal_bone_marrow1.04122319
93MP0002272_abnormal_nervous_system1.03631790
94MP0003787_abnormal_imprinting1.03082607
95MP0002876_abnormal_thyroid_physiology1.02510360
96MP0005257_abnormal_intraocular_pressure1.02414068
97MP0004808_abnormal_hematopoietic_stem1.02273117
98MP0000313_abnormal_cell_death1.01963175
99MP0003635_abnormal_synaptic_transmissio1.01617000
100MP0002084_abnormal_developmental_patter1.01100439
101MP0003283_abnormal_digestive_organ1.00284063
102MP0008877_abnormal_DNA_methylation1.00158981
103MP0001243_abnormal_dermal_layer0.99287516
104MP0002019_abnormal_tumor_incidence0.98783224
105MP0003315_abnormal_perineum_morphology0.98217809
106MP0001486_abnormal_startle_reflex0.98079277
107MP0004142_abnormal_muscle_tone0.97293237
108MP0005397_hematopoietic_system_phenotyp0.96377428
109MP0001545_abnormal_hematopoietic_system0.96377428
110MP0002085_abnormal_embryonic_tissue0.95630029
111MP0009785_altered_susceptibility_to0.95083423
112MP0002060_abnormal_skin_morphology0.95054397
113MP0002396_abnormal_hematopoietic_system0.94324091
114MP0000358_abnormal_cell_content/0.93800212
115MP0003045_fibrosis0.93787001
116MP0003221_abnormal_cardiomyocyte_apopto0.93180838
117MP0005645_abnormal_hypothalamus_physiol0.92694753
118MP0004859_abnormal_synaptic_plasticity0.91260300
119MP0005220_abnormal_exocrine_pancreas0.90049512
120MP0005167_abnormal_blood-brain_barrier0.89922088
121MP0001851_eye_inflammation0.88444782
122MP0002933_joint_inflammation0.88432185
123MP0009053_abnormal_anal_canal0.88046199
124MP0002332_abnormal_exercise_endurance0.87078075
125MP0009046_muscle_twitch0.87029232
126MP0002160_abnormal_reproductive_system0.86400202
127MP0002733_abnormal_thermal_nociception0.86316212
128MP0008875_abnormal_xenobiotic_pharmacok0.85479495
129MP0005508_abnormal_skeleton_morphology0.83020454
130MP0000516_abnormal_urinary_system0.82755173
131MP0005367_renal/urinary_system_phenotyp0.82755173
132MP0005076_abnormal_cell_differentiation0.82510177
133MP0003828_pulmonary_edema0.82144178
134MP0001835_abnormal_antigen_presentation0.81879472
135MP0009840_abnormal_foam_cell0.81214444
136MP0003763_abnormal_thymus_physiology0.80303825
137MP0003252_abnormal_bile_duct0.79795298
138MP0010329_abnormal_lipoprotein_level0.79594171
139MP0002111_abnormal_tail_morphology0.79529913
140MP0003633_abnormal_nervous_system0.78510870
141MP0002277_abnormal_respiratory_mucosa0.77712500
142MP0005389_reproductive_system_phenotype0.77565163
143MP0001873_stomach_inflammation0.77496502
144MP0003122_maternal_imprinting0.77315970
145MP0000920_abnormal_myelination0.77235838
146MP0003279_aneurysm0.75276938
147MP0002735_abnormal_chemical_nociception0.75258887
148MP0000678_abnormal_parathyroid_gland0.75028032
149MP0000685_abnormal_immune_system0.74738259
150MP0005671_abnormal_response_to0.74010526
151MP0005408_hypopigmentation0.73945024
152MP0002653_abnormal_ependyma_morphology0.73649911
153MP0005058_abnormal_lysosome_morphology0.73357899
154MP0005384_cellular_phenotype0.73243829
155MP0001970_abnormal_pain_threshold0.73096135
156MP0002063_abnormal_learning/memory/cond0.72905888
157MP0004133_heterotaxia0.72883160
158MP0003329_amyloid_beta_deposits0.72183096
159MP0002693_abnormal_pancreas_physiology0.72079750
160MP0008872_abnormal_physiological_respon0.72009039
161MP0000013_abnormal_adipose_tissue0.71431903
162MP0003448_altered_tumor_morphology0.70825005
163MP0005390_skeleton_phenotype0.67937970
164MP0009763_increased_sensitivity_to0.67402458
165MP0001764_abnormal_homeostasis0.67328992
166MP0002938_white_spotting0.67308523
167MP0005535_abnormal_body_temperature0.67185690
168MP0008569_lethality_at_weaning0.66541552
169MP0004130_abnormal_muscle_cell0.66398589
170MP0001663_abnormal_digestive_system0.66236343
171MP0005621_abnormal_cell_physiology0.65975269
172MP0002722_abnormal_immune_system0.65734276
173MP0000163_abnormal_cartilage_morphology0.65304593
174MP0002398_abnormal_bone_marrow0.64413365
175MP0001293_anophthalmia0.64195564
176MP0003724_increased_susceptibility_to0.62736829
177MP0003890_abnormal_embryonic-extraembry0.62599075
178MP0000477_abnormal_intestine_morphology0.62328799
179MP0002210_abnormal_sex_determination0.62273112
180MP0000689_abnormal_spleen_morphology0.62190396
181MP0002429_abnormal_blood_cell0.61234603
182MP0003943_abnormal_hepatobiliary_system0.61002942
183MP0002113_abnormal_skeleton_development0.60561277

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.36037619
2T lymphocytopenia (HP:0005403)4.36161686
3Elevated erythrocyte sedimentation rate (HP:0003565)4.36074138
4Abnormality of T cell number (HP:0011839)4.14988511
5Carpal bone hypoplasia (HP:0001498)3.77301695
6Severe combined immunodeficiency (HP:0004430)3.76861225
7Irregular epiphyses (HP:0010582)3.62406238
8Myositis (HP:0100614)3.59842394
9IgG deficiency (HP:0004315)3.44797379
10Birth length less than 3rd percentile (HP:0003561)3.41309969
11Recurrent fungal infections (HP:0002841)3.39933190
12Thyroiditis (HP:0100646)3.35050253
13Abnormality of eosinophils (HP:0001879)3.34072365
1411 pairs of ribs (HP:0000878)3.32269186
15Gastrointestinal infarctions (HP:0005244)3.30572653
16Degeneration of anterior horn cells (HP:0002398)3.30045857
17Abnormality of the anterior horn cell (HP:0006802)3.30045857
18Eosinophilia (HP:0001880)3.26567844
19Leukocytosis (HP:0001974)3.21426447
20Aplastic anemia (HP:0001915)3.16950333
21Abnormality of T cells (HP:0002843)3.15311082
22Granulocytopenia (HP:0001913)3.13058802
23Optic neuritis (HP:0100653)3.10860285
24Retrobulbar optic neuritis (HP:0100654)3.10860285
25Breast hypoplasia (HP:0003187)3.02509702
26Orchitis (HP:0100796)3.00306706
27Eczematoid dermatitis (HP:0000976)2.99349738
28Recurrent abscess formation (HP:0002722)2.97470407
29Pulmonary infiltrates (HP:0002113)2.96648894
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.96104618
31Recurrent cutaneous fungal infections (HP:0011370)2.92457693
32Chronic mucocutaneous candidiasis (HP:0002728)2.92457693
33Flat capital femoral epiphysis (HP:0003370)2.90698996
34Vasculitis (HP:0002633)2.88621399
35Papilledema (HP:0001085)2.85421500
36Recurrent bacterial skin infections (HP:0005406)2.84344403
37Cervical subluxation (HP:0003308)2.83096725
38Abnormality of the prostate (HP:0008775)2.82198828
39Rough bone trabeculation (HP:0100670)2.81519196
40Abnormality of macrophages (HP:0004311)2.81481385
41Combined immunodeficiency (HP:0005387)2.80487490
42Meningitis (HP:0001287)2.80272192
43Encephalitis (HP:0002383)2.78720354
44Protrusio acetabuli (HP:0003179)2.76466421
45Reticulocytopenia (HP:0001896)2.76322705
46Trismus (HP:0000211)2.74561649
47Autoimmune hemolytic anemia (HP:0001890)2.73691164
48Vertebral compression fractures (HP:0002953)2.72025500
49Agammaglobulinemia (HP:0004432)2.71471031
50Abnormality of cells of the erythroid lineage (HP:0012130)2.71084984
51Metaphyseal cupping (HP:0003021)2.69485690
52Selective tooth agenesis (HP:0001592)2.68042802
53Mediastinal lymphadenopathy (HP:0100721)2.67319868
54Panhypogammaglobulinemia (HP:0003139)2.66215534
55Hemoptysis (HP:0002105)2.64424793
56Abnormality of B cell number (HP:0010975)2.57785169
57Abnormal number of erythroid precursors (HP:0012131)2.56979396
58Chronic diarrhea (HP:0002028)2.55146139
59Beaking of vertebral bodies (HP:0004568)2.54731744
60Episodic fever (HP:0001954)2.54429428
61Secondary amenorrhea (HP:0000869)2.54171683
62Pustule (HP:0200039)2.52828828
63Thrombocytosis (HP:0001894)2.52428650
64Epiphyseal dysplasia (HP:0002656)2.52420392
65Missing ribs (HP:0000921)2.52108747
66Chronic obstructive pulmonary disease (HP:0006510)2.52051901
67Obstructive lung disease (HP:0006536)2.52051901
68Increased IgM level (HP:0003496)2.49615961
69Type I transferrin isoform profile (HP:0003642)2.48717978
70Chest pain (HP:0100749)2.47660828
71Delayed epiphyseal ossification (HP:0002663)2.45770326
72Clumsiness (HP:0002312)2.43863797
73Premature rupture of membranes (HP:0001788)2.42808477
74Stomach cancer (HP:0012126)2.39363800
75Small epiphyses (HP:0010585)2.37016516
76Absent speech (HP:0001344)2.36194990
77Recurrent viral infections (HP:0004429)2.36185353
78Febrile seizures (HP:0002373)2.35578356
79Multiple enchondromatosis (HP:0005701)2.33975982
80Epistaxis (HP:0000421)2.33422600
81Diplopia (HP:0000651)2.33289068
82Abnormality of binocular vision (HP:0011514)2.33289068
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.33103208
84Poor head control (HP:0002421)2.31282997
85Gingival bleeding (HP:0000225)2.29715667
86Recurrent skin infections (HP:0001581)2.26341596
87Prolonged bleeding time (HP:0003010)2.25786455
88Autoimmune thrombocytopenia (HP:0001973)2.25020013
89Abnormality of the distal phalanges of the toes (HP:0010182)2.22236121
90Neoplasm of the tracheobronchial system (HP:0100552)2.21994540
91Abnormal trabecular bone morphology (HP:0100671)2.21468862
92Oral leukoplakia (HP:0002745)2.20596319
93Biconcave vertebral bodies (HP:0004586)2.20541278
94Flattened epiphyses (HP:0003071)2.20195529
95Petechiae (HP:0000967)2.20188853
96Microretrognathia (HP:0000308)2.19378925
97Abnormality of the pleura (HP:0002103)2.18777528
98Joint swelling (HP:0001386)2.18094692
99Cleft eyelid (HP:0000625)2.18079941
100Lymphopenia (HP:0001888)2.18016261
101Atonic seizures (HP:0010819)2.16844783
102Genu varum (HP:0002970)2.16525344
103Mutism (HP:0002300)2.15523987
104Glossoptosis (HP:0000162)2.15297155
105B lymphocytopenia (HP:0010976)2.14306392
106Patent foramen ovale (HP:0001655)2.12176601
107Facial diplegia (HP:0001349)2.11575650
108Breech presentation (HP:0001623)2.10964890
109Dysostosis multiplex (HP:0000943)2.10941981
110Platyspondyly (HP:0000926)2.10607072
111Cupped ribs (HP:0000887)2.10440332
112Abnormality of the calcaneus (HP:0008364)2.10438763
113Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09940163
114Abnormality of T cell physiology (HP:0011840)2.09734333
115Irregular vertebral endplates (HP:0003301)2.09340673
116Hypoproteinemia (HP:0003075)2.09200358
117Patellar aplasia (HP:0006443)2.08258503
118Hypergammaglobulinemia (HP:0010702)2.04593865
119Keratoconjunctivitis sicca (HP:0001097)2.03405065
120Vacuolated lymphocytes (HP:0001922)2.03212063
121Premature ovarian failure (HP:0008209)2.02636207
122Toxemia of pregnancy (HP:0100603)2.02075017
123Alveolar cell carcinoma (HP:0006519)2.01649741
124Abnormality of liposaccharide metabolism (HP:0010968)2.01465233
125Abnormality of glycosphingolipid metabolism (HP:0004343)2.01465233
126Abnormality of glycolipid metabolism (HP:0010969)2.01465233
127Cerebral hypomyelination (HP:0006808)2.01045026
128Recurrent bronchitis (HP:0002837)2.00023959
129Increased cerebral lipofuscin (HP:0011813)1.99360059
130Keratoconjunctivitis (HP:0001096)1.98998431
131Congenital stationary night blindness (HP:0007642)1.98600816
132Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.97648840
133Absent epiphyses (HP:0010577)1.97648840
134Metaphyseal dysplasia (HP:0100255)1.96738869
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.95069560
136Sparse eyelashes (HP:0000653)1.94804704
137Aplasia/Hypoplasia of the patella (HP:0006498)1.94032812
138Macrocytic anemia (HP:0001972)1.92998473
139Pulmonary embolism (HP:0002204)1.92027471
140Abnormal tarsal ossification (HP:0008369)1.90223522
141Vertebral hypoplasia (HP:0008417)1.90136537
142Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.90136537
143Abnormal protein glycosylation (HP:0012346)1.90108348
144Abnormal glycosylation (HP:0012345)1.90108348
145Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90108348
146Abnormal protein N-linked glycosylation (HP:0012347)1.90108348
147Abnormality of cells of the lymphoid lineage (HP:0012140)1.89799332
148Abnormal pancreas size (HP:0012094)1.87381656
149Abolished electroretinogram (ERG) (HP:0000550)1.86798678
150Abnormality of femoral epiphyses (HP:0006499)1.86359589
151Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.86359589
152Abnormality of the acetabulum (HP:0003170)1.86279966
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86260065
154Abnormality of polysaccharide metabolism (HP:0011012)1.86260065
155Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86260065
156Inflammation of the large intestine (HP:0002037)1.86176713
157Vertigo (HP:0002321)1.85860964
158Colon cancer (HP:0003003)1.84875316
159Spinal muscular atrophy (HP:0007269)1.83779848
160Pulmonary fibrosis (HP:0002206)1.81403115
161Chronic otitis media (HP:0000389)1.81248187
162Premature graying of hair (HP:0002216)1.79660334
163Bile duct proliferation (HP:0001408)1.79557606
164Abnormal biliary tract physiology (HP:0012439)1.79557606
165Polyneuropathy (HP:0001271)1.79508378
166Parakeratosis (HP:0001036)1.79468594
167Gangrene (HP:0100758)1.79016542
168Increased CSF protein (HP:0002922)1.78711858
169IgM deficiency (HP:0002850)1.78315123
1703-Methylglutaconic aciduria (HP:0003535)1.78042107
171Abnormality of the vertebral endplates (HP:0005106)1.77668519
172Abnormality of the epiphysis of the femoral head (HP:0010574)1.77640975
173Abnormal foot bone ossification (HP:0010675)1.77629472
174Flat acetabular roof (HP:0003180)1.76784553
175Micronodular cirrhosis (HP:0001413)1.73926559
176Stillbirth (HP:0003826)1.73429196
177Aplasia/hypoplasia of the humerus (HP:0006507)1.73377130
178Slender long bone (HP:0003100)1.73208923
179Abnormality of dentin (HP:0010299)1.73152466
180Nonimmune hydrops fetalis (HP:0001790)1.72775522
181Absent thumb (HP:0009777)1.72462923
182Neonatal short-limb short stature (HP:0008921)1.71845243
183Pallor (HP:0000980)1.71747394
184Hypoplasia of the pons (HP:0012110)1.71089992
185Abnormality of the proximal phalanges of the hand (HP:0009834)1.71030732
186Hand muscle atrophy (HP:0009130)1.70632305
187Coxa vara (HP:0002812)1.69695289
188Abnormality of the umbilical cord (HP:0010881)1.69071490
189Abnormal vertebral ossification (HP:0100569)1.67524474
190Ankle contracture (HP:0006466)1.67184340
191Fused cervical vertebrae (HP:0002949)1.66543044
192Spinal cord compression (HP:0002176)1.66057908
193Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65388225
194Abnormality of the femoral head (HP:0003368)1.65022305
195Neoplasm of the pancreas (HP:0002894)1.63874381
196Soft skin (HP:0000977)1.60015874
197Atrophy/Degeneration involving motor neurons (HP:0007373)1.59580910
198Facial cleft (HP:0002006)1.59175024
199Optic nerve coloboma (HP:0000588)1.59160271
200Short nail (HP:0001799)1.58649796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.11906107
2WEE13.40787401
3NME23.40243292
4RIPK43.38613568
5MAP4K13.37438053
6EPHA23.05350327
7EIF2AK12.88333010
8STK162.65306332
9TAOK32.62010980
10PLK42.49960566
11EIF2AK32.41505064
12FRK2.35562730
13DAPK22.35137543
14PIM22.28815797
15BRSK22.27902657
16FES2.22200531
17PASK2.19015556
18TNK22.16375669
19TESK12.03790605
20RPS6KB21.98185359
21MAP3K31.90620094
22TSSK61.90544538
23BMPR21.87542724
24SIK31.86290551
25SYK1.79294779
26MAP3K131.78302870
27STK38L1.77784179
28ITK1.76352924
29RPS6KA41.72925752
30IKBKE1.71461890
31TEC1.69066054
32ACVR1B1.62964585
33MAP3K141.62197652
34CDC71.56140753
35SRPK11.52981712
36GRK61.52422486
37BTK1.52126692
38MAP4K21.51871269
39KIT1.50220867
40TESK21.45593740
41ADRBK21.45083917
42ZAK1.43669589
43TTK1.42961206
44BLK1.42406669
45TGFBR11.38452710
46KDR1.37692099
47SIK21.36272075
48PLK11.34494732
49GRK71.31476397
50CSF1R1.29904883
51JAK11.29203279
52FLT31.26999679
53EPHA41.25736547
54LCK1.24880070
55CDK71.23201956
56AURKB1.22721805
57CAMKK21.22170436
58HCK1.20761520
59NEK21.19121632
60MAPK131.18630619
61MST41.16891462
62PRKCQ1.15117161
63LYN1.14778243
64NEK11.12985688
65MAP3K81.12848569
66PAK41.10900745
67PLK31.08163408
68CSK1.07532217
69PINK11.05727318
70STK101.03329690
71VRK11.03101118
72AKT31.02852019
73ATR1.00235361
74NME10.99455634
75STK240.99156428
76PIM10.96010964
77BRSK10.93084078
78BMPR1B0.92670616
79JAK20.90931808
80NTRK30.90140387
81MAPKAPK30.89721444
82LRRK20.88777271
83AURKA0.87267304
84MAP3K110.87043068
85DYRK30.86621967
86PBK0.85361726
87IRAK30.85091194
88PRKG20.84994417
89PDK10.84600316
90MYLK0.83908156
91BCKDK0.82909636
92JAK30.82743575
93MARK30.82292243
94CHEK20.81537282
95BRAF0.79530925
96PRKCI0.78377172
97CDK40.78091514
98DDR20.77756727
99LIMK10.77664200
100MAP2K20.77184012
101CAMKK10.74884951
102ERN10.74614878
103MAP2K30.74089605
104FGR0.73549695
105MKNK10.73331571
106PAK10.71846154
107NUAK10.71136671
108ARAF0.69911684
109IRAK10.67195488
110CDK190.66510953
111EPHA30.66486098
112ZAP700.66360776
113MAP3K120.65754524
114TBK10.65612659
115NEK90.65085681
116SCYL20.65049465
117DAPK10.65020224
118MAP2K60.64997432
119PRKD20.64977521
120MAP3K50.64895240
121INSRR0.64008933
122STK30.63772499
123GRK50.63038020
124EIF2AK20.60625423
125CHEK10.60283615
126CSNK2A10.59849982
127PRKCE0.59114217
128MAPK120.58487176
129PTK2B0.57829796
130PAK60.57293940
131ILK0.56549792
132PRKCH0.55856048
133IKBKB0.55537558
134MKNK20.52325333
135EPHB10.51381228
136PAK30.51177507
137NLK0.50778829
138MET0.50515216
139PDK20.49234984
140TRIM280.48822976
141ABL10.48691334
142PHKG10.47521847
143PHKG20.47521847
144TLK10.46765247
145MAPKAPK20.46425334
146FYN0.46307684
147OXSR10.45404633
148CHUK0.44691934
149RPS6KA50.43276254
150CSNK2A20.42962760
151CDK80.42677335
152PDK30.42005066
153PDK40.42005066
154MAP3K40.41001632
155PIK3CG0.40125088
156NEK60.39956730
157TXK0.39749471
158ATM0.38452691
159TYK20.37188515
160IGF1R0.37178960
161MAP2K10.36868150
162TGFBR20.36814049
163MAP3K70.36363436
164PDPK10.35951292
165GRK10.35377205
166PRKD30.35364746
167MAPK110.35262343
168MELK0.35124527
169PRKCZ0.34860584
170CDK20.34499846
171PAK20.34275460
172LATS10.34004553
173FER0.33389693
174IRAK40.33344145
175ERBB30.33182096
176PIK3CA0.32166956
177ADRBK10.31912637
178LATS20.31591135

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.22884347
2DNA replication_Homo sapiens_hsa030303.52993937
3Ribosome_Homo sapiens_hsa030103.50064079
4RNA polymerase_Homo sapiens_hsa030203.21022987
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17228089
6Mismatch repair_Homo sapiens_hsa034302.96459853
7Autoimmune thyroid disease_Homo sapiens_hsa053202.95778749
8Protein export_Homo sapiens_hsa030602.81076235
9RNA transport_Homo sapiens_hsa030132.62831673
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47958175
11Nucleotide excision repair_Homo sapiens_hsa034202.44995597
12Spliceosome_Homo sapiens_hsa030402.35677128
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28980045
14Pyrimidine metabolism_Homo sapiens_hsa002402.28296997
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.24567166
16Base excision repair_Homo sapiens_hsa034102.22739268
17Homologous recombination_Homo sapiens_hsa034402.15000756
18Cell cycle_Homo sapiens_hsa041102.02737257
19Rheumatoid arthritis_Homo sapiens_hsa053231.99386171
20Staphylococcus aureus infection_Homo sapiens_hsa051501.96960041
21One carbon pool by folate_Homo sapiens_hsa006701.96111823
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89638860
23T cell receptor signaling pathway_Homo sapiens_hsa046601.83390322
24Basal transcription factors_Homo sapiens_hsa030221.72689497
25Osteoclast differentiation_Homo sapiens_hsa043801.69791999
26p53 signaling pathway_Homo sapiens_hsa041151.59650744
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59635471
28Folate biosynthesis_Homo sapiens_hsa007901.54793238
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.49342884
30Tuberculosis_Homo sapiens_hsa051521.48052614
31Caffeine metabolism_Homo sapiens_hsa002321.38440555
32RNA degradation_Homo sapiens_hsa030181.35906829
33Antigen processing and presentation_Homo sapiens_hsa046121.33960354
34B cell receptor signaling pathway_Homo sapiens_hsa046621.32241586
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27558336
36Fanconi anemia pathway_Homo sapiens_hsa034601.25595325
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.25435284
38Epstein-Barr virus infection_Homo sapiens_hsa051691.24666227
39Viral myocarditis_Homo sapiens_hsa054161.21325175
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18031803
41Purine metabolism_Homo sapiens_hsa002301.17855676
42Non-homologous end-joining_Homo sapiens_hsa034501.10689336
43Legionellosis_Homo sapiens_hsa051341.08727629
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.08627368
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08163840
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07320788
47Nicotine addiction_Homo sapiens_hsa050331.07148294
48African trypanosomiasis_Homo sapiens_hsa051431.07052818
49Collecting duct acid secretion_Homo sapiens_hsa049661.06110687
50Toxoplasmosis_Homo sapiens_hsa051451.04852966
51Lysosome_Homo sapiens_hsa041421.03974931
52Morphine addiction_Homo sapiens_hsa050321.03428531
53Synaptic vesicle cycle_Homo sapiens_hsa047211.03047060
54Phototransduction_Homo sapiens_hsa047441.02677635
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02659174
56Chemokine signaling pathway_Homo sapiens_hsa040621.01707796
57TNF signaling pathway_Homo sapiens_hsa046681.01475510
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97867641
59Galactose metabolism_Homo sapiens_hsa000520.94971380
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94899857
61Fructose and mannose metabolism_Homo sapiens_hsa000510.93608154
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91210991
63Pentose phosphate pathway_Homo sapiens_hsa000300.91023681
64Selenocompound metabolism_Homo sapiens_hsa004500.90792880
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90131164
66Platelet activation_Homo sapiens_hsa046110.89413319
67mRNA surveillance pathway_Homo sapiens_hsa030150.86488931
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86295443
69Salivary secretion_Homo sapiens_hsa049700.85700864
70Amphetamine addiction_Homo sapiens_hsa050310.85566701
71N-Glycan biosynthesis_Homo sapiens_hsa005100.85082908
72Renin secretion_Homo sapiens_hsa049240.83792299
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83135053
74Viral carcinogenesis_Homo sapiens_hsa052030.83045313
75Herpes simplex infection_Homo sapiens_hsa051680.82974893
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82223631
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80872518
78Phagosome_Homo sapiens_hsa041450.79261313
79GABAergic synapse_Homo sapiens_hsa047270.77733374
80Pertussis_Homo sapiens_hsa051330.77266730
81Huntingtons disease_Homo sapiens_hsa050160.77000690
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.76492641
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75154771
84Ether lipid metabolism_Homo sapiens_hsa005650.74904981
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.72757185
86Circadian entrainment_Homo sapiens_hsa047130.71331329
87Parkinsons disease_Homo sapiens_hsa050120.70667169
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70243403
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69478209
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68780624
91Glutathione metabolism_Homo sapiens_hsa004800.68427421
92Thyroid cancer_Homo sapiens_hsa052160.67525127
93Oxidative phosphorylation_Homo sapiens_hsa001900.67057579
94Malaria_Homo sapiens_hsa051440.65741882
95Insulin secretion_Homo sapiens_hsa049110.64629768
96Calcium signaling pathway_Homo sapiens_hsa040200.63827554
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63735642
98Sulfur relay system_Homo sapiens_hsa041220.63219131
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62608578
100Long-term potentiation_Homo sapiens_hsa047200.61899829
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61420521
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60435047
103HTLV-I infection_Homo sapiens_hsa051660.59506904
104Arachidonic acid metabolism_Homo sapiens_hsa005900.59083905
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58958083
106Biosynthesis of amino acids_Homo sapiens_hsa012300.58260116
107Shigellosis_Homo sapiens_hsa051310.58224091
108Sulfur metabolism_Homo sapiens_hsa009200.57486803
109Regulation of autophagy_Homo sapiens_hsa041400.56881126
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56740572
111Mineral absorption_Homo sapiens_hsa049780.56475714
112Other glycan degradation_Homo sapiens_hsa005110.56445150
113ECM-receptor interaction_Homo sapiens_hsa045120.55586406
114Apoptosis_Homo sapiens_hsa042100.55355629
115Olfactory transduction_Homo sapiens_hsa047400.54842727
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54446846
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.54136088
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.53670864
119Vibrio cholerae infection_Homo sapiens_hsa051100.53117832
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52658553
121ABC transporters_Homo sapiens_hsa020100.52455698
122Measles_Homo sapiens_hsa051620.51988758
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.50389981
124Oxytocin signaling pathway_Homo sapiens_hsa049210.49513456
125TGF-beta signaling pathway_Homo sapiens_hsa043500.49115089
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.47697097
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47222981
128Endocytosis_Homo sapiens_hsa041440.47150776
129Salmonella infection_Homo sapiens_hsa051320.46856444
130Asthma_Homo sapiens_hsa053100.46756037
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46743818
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.44859363
133Allograft rejection_Homo sapiens_hsa053300.44550641
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43989545
135Hippo signaling pathway_Homo sapiens_hsa043900.43323497
136Gastric acid secretion_Homo sapiens_hsa049710.43180911
137Influenza A_Homo sapiens_hsa051640.43175406
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42996185
139Bladder cancer_Homo sapiens_hsa052190.42085259
140Small cell lung cancer_Homo sapiens_hsa052220.41327582
141Protein digestion and absorption_Homo sapiens_hsa049740.41309787
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41042923
143Graft-versus-host disease_Homo sapiens_hsa053320.40919700
144Circadian rhythm_Homo sapiens_hsa047100.40830941
145Glutamatergic synapse_Homo sapiens_hsa047240.40729048
146Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40609812
147cAMP signaling pathway_Homo sapiens_hsa040240.40317369
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39560539
149Cholinergic synapse_Homo sapiens_hsa047250.39065128
150Taste transduction_Homo sapiens_hsa047420.38792312
151Dopaminergic synapse_Homo sapiens_hsa047280.38771874
152Adherens junction_Homo sapiens_hsa045200.38617161
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.38399918
154Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37942161
155Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37790768
156Type I diabetes mellitus_Homo sapiens_hsa049400.37351048
157Serotonergic synapse_Homo sapiens_hsa047260.37328838
158Carbon metabolism_Homo sapiens_hsa012000.36686304
159Primary immunodeficiency_Homo sapiens_hsa053400.36548946
160Systemic lupus erythematosus_Homo sapiens_hsa053220.35599165
161Metabolic pathways_Homo sapiens_hsa011000.34606858
162Intestinal immune network for IgA production_Homo sapiens_hsa046720.33558687
163Vitamin B6 metabolism_Homo sapiens_hsa007500.32770354
164SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32645325
165Oocyte meiosis_Homo sapiens_hsa041140.32547149
166Hematopoietic cell lineage_Homo sapiens_hsa046400.32153255
167Hepatitis B_Homo sapiens_hsa051610.31000475
168HIF-1 signaling pathway_Homo sapiens_hsa040660.29050614
169Renin-angiotensin system_Homo sapiens_hsa046140.28445292
170NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26201722
171Linoleic acid metabolism_Homo sapiens_hsa005910.24799702
172MicroRNAs in cancer_Homo sapiens_hsa052060.24200867
173Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23359160
174Leishmaniasis_Homo sapiens_hsa051400.23075199

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