TBX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hair cycle (GO:0042633)8.93139532
2molting cycle (GO:0042303)8.93139532
3keratinization (GO:0031424)8.82473523
4hemidesmosome assembly (GO:0031581)7.86056696
5desmosome organization (GO:0002934)6.92507534
6regulation of skeletal muscle contraction (GO:0014819)6.49095492
7actin-myosin filament sliding (GO:0033275)6.27935973
8muscle filament sliding (GO:0030049)6.27935973
9peptide cross-linking (GO:0018149)5.78767905
10skeletal muscle adaptation (GO:0043501)5.65527688
11skeletal muscle contraction (GO:0003009)5.45098984
12* muscle cell fate commitment (GO:0042693)5.43171017
13sarcoplasmic reticulum calcium ion transport (GO:0070296)5.26430481
14actin-mediated cell contraction (GO:0070252)5.20593944
15plasma membrane repair (GO:0001778)5.15472889
16oxidative phosphorylation (GO:0006119)5.02946702
17skeletal muscle fiber development (GO:0048741)4.98277988
18motile cilium assembly (GO:0044458)4.84468717
19establishment of skin barrier (GO:0061436)4.73199546
20cell wall macromolecule catabolic process (GO:0016998)4.56329473
21cell wall macromolecule metabolic process (GO:0044036)4.56329473
22DNA packaging (GO:0006323)4.51660067
23chromosome condensation (GO:0030261)4.50032435
24regulation of water loss via skin (GO:0033561)4.48034063
25negative regulation of cell fate specification (GO:0009996)4.33841627
26actin filament-based movement (GO:0030048)4.21095122
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.19263215
28myotube cell development (GO:0014904)3.98209583
29keratinocyte differentiation (GO:0030216)3.96482091
30acrosome reaction (GO:0007340)3.96233972
31myotube differentiation (GO:0014902)3.95356248
32cell-substrate junction assembly (GO:0007044)3.92260359
33bundle of His cell to Purkinje myocyte communication (GO:0086069)3.90714298
34sperm capacitation (GO:0048240)3.85966009
35striated muscle atrophy (GO:0014891)3.85098527
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.83215266
37intermediate filament organization (GO:0045109)3.81992225
38axonemal dynein complex assembly (GO:0070286)3.81729194
39embryonic heart tube development (GO:0035050)3.73828839
40peptidyl-arginine omega-N-methylation (GO:0035247)3.72244938
41epidermis development (GO:0008544)3.70918097
42positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.70859494
43regulation of keratinocyte differentiation (GO:0045616)3.67600343
44skin morphogenesis (GO:0043589)3.66770824
45regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.47724320
46negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.45865393
47sarcomere organization (GO:0045214)3.40233025
48G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.37243991
49epithelial cell-cell adhesion (GO:0090136)3.36762933
50mitotic G1 DNA damage checkpoint (GO:0031571)3.36579089
51amyloid precursor protein catabolic process (GO:0042987)3.36465043
52dorsal/ventral neural tube patterning (GO:0021904)3.36159492
53negative regulation of cell size (GO:0045792)3.35866694
54multicellular organismal water homeostasis (GO:0050891)3.34777863
55sperm motility (GO:0030317)3.33753527
56ribosomal small subunit biogenesis (GO:0042274)3.31247668
57regulation of mammary gland epithelial cell proliferation (GO:0033599)3.30512160
58mammary gland epithelial cell differentiation (GO:0060644)3.30191254
59myofibril assembly (GO:0030239)3.29522470
60epidermal cell differentiation (GO:0009913)3.26613475
61myoblast fusion (GO:0007520)3.24687850
62cardiac myofibril assembly (GO:0055003)3.24378948
63histone arginine methylation (GO:0034969)3.20705012
64embryonic skeletal joint morphogenesis (GO:0060272)3.17233350
65negative regulation of Notch signaling pathway (GO:0045746)3.16620545
66microtubule severing (GO:0051013)3.14477943
67striated muscle contraction (GO:0006941)3.13942676
68muscle atrophy (GO:0014889)3.11915821
69notochord development (GO:0030903)3.11891052
70negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.11577426
71NADH metabolic process (GO:0006734)3.09230599
72regulation of cardioblast differentiation (GO:0051890)3.08593851
73neuron fate specification (GO:0048665)3.07999838
74response to muscle activity (GO:0014850)3.07334054
75cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.05920435
76syncytium formation by plasma membrane fusion (GO:0000768)3.05686008
77hair follicle morphogenesis (GO:0031069)3.04731758
78peptidyl-arginine N-methylation (GO:0035246)3.02488430
79peptidyl-arginine methylation (GO:0018216)3.02488430
80proline biosynthetic process (GO:0006561)3.01216052
81striated muscle adaptation (GO:0014888)3.00899213
82kidney mesenchyme development (GO:0072074)2.97944353
83non-canonical Wnt signaling pathway (GO:0035567)2.97572018
84gluconeogenesis (GO:0006094)2.96317337
85skeletal muscle tissue regeneration (GO:0043403)2.95537867
86adhesion of symbiont to host cell (GO:0044650)2.95197311
87virion attachment to host cell (GO:0019062)2.95197311
88syncytium formation (GO:0006949)2.93527973
89* muscle organ morphogenesis (GO:0048644)2.92714793
90lung-associated mesenchyme development (GO:0060484)2.92495179
91negative regulation of cell fate commitment (GO:0010454)2.92373456
92heterochromatin organization (GO:0070828)2.92152951
93muscle fiber development (GO:0048747)2.89963719
94epithelial cell differentiation involved in prostate gland development (GO:0060742)2.89800169
95* regulation of heart morphogenesis (GO:2000826)2.87005218
96muscle contraction (GO:0006936)2.86873131
97regulation of cell fate specification (GO:0042659)2.86868779
98* regulation of secondary heart field cardioblast proliferation (GO:0003266)2.86748925
99* regulation of cardioblast proliferation (GO:0003264)2.86748925
100regulation of translational fidelity (GO:0006450)2.86470623
101negative regulation of catenin import into nucleus (GO:0035414)2.85617626
102G1 DNA damage checkpoint (GO:0044783)2.85463635
103actomyosin structure organization (GO:0031032)2.84497808
104microtubule depolymerization (GO:0007019)2.83640615
105spermatid nucleus differentiation (GO:0007289)2.83170734
106* lymph vessel development (GO:0001945)2.83065587
107mitotic G1/S transition checkpoint (GO:0044819)2.81705568
108pentose metabolic process (GO:0019321)2.81660293
109* embryonic cranial skeleton morphogenesis (GO:0048701)2.79945404
110* thyroid gland development (GO:0030878)2.79266758
111membrane protein intracellular domain proteolysis (GO:0031293)2.78718316
112left/right pattern formation (GO:0060972)2.78623902
113chromatin silencing (GO:0006342)2.77020197
114response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.75216614
115heart trabecula formation (GO:0060347)2.74798080
116cytoskeletal anchoring at plasma membrane (GO:0007016)2.73584008
117regulation of transcription involved in cell fate commitment (GO:0060850)2.73564283
118protein-DNA complex disassembly (GO:0032986)2.72871138
119nucleosome disassembly (GO:0006337)2.72871138
120rRNA modification (GO:0000154)2.72414467
121pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72239968
122hexose biosynthetic process (GO:0019319)2.71848115
123DNA replication checkpoint (GO:0000076)2.71649721
124intracellular estrogen receptor signaling pathway (GO:0030520)2.70551427
125endodermal cell differentiation (GO:0035987)2.70383638
126polyamine biosynthetic process (GO:0006596)2.69640462
127anatomical structure regression (GO:0060033)2.69332464
128skin development (GO:0043588)2.69119821
129amyloid precursor protein metabolic process (GO:0042982)2.68998194
130carnitine shuttle (GO:0006853)2.68929936
131glycogen catabolic process (GO:0005980)2.68201508
132peptidyl-histidine modification (GO:0018202)2.66930675
133polarized epithelial cell differentiation (GO:0030859)2.66810895
134rRNA methylation (GO:0031167)2.66421554
135* odontogenesis (GO:0042476)2.66162262
136* positive regulation of myotube differentiation (GO:0010831)2.65205066
137regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.64164256
138regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.63790032
139rRNA transcription (GO:0009303)2.63217827
140purine nucleotide salvage (GO:0032261)2.62913859
141fusion of sperm to egg plasma membrane (GO:0007342)2.62900751
142binding of sperm to zona pellucida (GO:0007339)2.62373177
143cardiac muscle contraction (GO:0060048)2.62147737
144hair cycle process (GO:0022405)2.62133640
145molting cycle process (GO:0022404)2.62133640
146protein heterotrimerization (GO:0070208)2.62084139
147creatine metabolic process (GO:0006600)2.61889705
148regulation of p38MAPK cascade (GO:1900744)2.61832041
149spermatid development (GO:0007286)2.61773043
150ectoderm development (GO:0007398)2.61220563
151water homeostasis (GO:0030104)2.60591987
152regulation of epidermal cell differentiation (GO:0045604)2.59663275
1534-hydroxyproline metabolic process (GO:0019471)2.57632624
154* embryonic skeletal system morphogenesis (GO:0048704)2.57489527
155ubiquinone biosynthetic process (GO:0006744)2.56984836
156regulation of epidermis development (GO:0045682)2.56967720
157response to pheromone (GO:0019236)2.56809098
158regulation of apoptotic process involved in morphogenesis (GO:1902337)2.56269918
159atrial septum morphogenesis (GO:0060413)2.55807315
160response to inactivity (GO:0014854)2.55692954
161bone trabecula formation (GO:0060346)2.55215460
162peripheral nervous system neuron development (GO:0048935)2.54568732
163regulation of chromatin binding (GO:0035561)2.54303056
164apoptotic process involved in morphogenesis (GO:0060561)2.53729364
165negative regulation of cardiac muscle tissue growth (GO:0055022)2.49198725
166negative regulation of heart growth (GO:0061117)2.49198725
167* odontogenesis of dentin-containing tooth (GO:0042475)2.48785437
168hippo signaling (GO:0035329)2.48711432
169skeletal muscle tissue development (GO:0007519)2.48653169
170* muscle structure development (GO:0061061)2.48624329
171renal system development (GO:0072001)2.48588682
172regulation of somitogenesis (GO:0014807)2.47565853
173ATP biosynthetic process (GO:0006754)2.47115447
174regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.46660753
175muscle system process (GO:0003012)2.46580336
176protein hydroxylation (GO:0018126)2.46490372
177regulation of protein sumoylation (GO:0033233)2.46424532
178IMP metabolic process (GO:0046040)2.46301408
179negative regulation of skeletal muscle tissue development (GO:0048642)2.46057045
180proximal/distal pattern formation (GO:0009954)2.45758588
181regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.45576444
182metanephric mesenchyme development (GO:0072075)2.45238127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.39896241
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.14311422
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.91299345
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90583923
5ZNF263_19887448_ChIP-Seq_K562_Human2.76606882
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49477655
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.45830612
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.42217938
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.39940142
10P63_26484246_Chip-Seq_KERATINOCYTES_Human2.32418863
11TET1_21451524_ChIP-Seq_MESCs_Mouse2.20637764
12SOX9_24532713_ChIP-Seq_HFSC_Mouse2.20362659
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.18819534
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16382292
15XRN2_22483619_ChIP-Seq_HELA_Human2.16058849
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14285924
17ELF1_20517297_ChIP-Seq_JURKAT_Human2.09132803
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02412914
19TP63_17297297_ChIP-ChIP_HaCaT_Human10.3803906
20VDR_21846776_ChIP-Seq_THP-1_Human1.97250839
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95590512
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.95161072
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.94020632
24BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.91362285
25RACK7_27058665_Chip-Seq_MCF-7_Human1.91284592
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.84348870
27E2F7_22180533_ChIP-Seq_HELA_Human1.83583408
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81640917
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81065329
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78282782
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.77681908
32DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.77591166
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.77372227
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.72087065
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.71269149
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70035454
37CLOCK_20551151_ChIP-Seq_293T_Human1.69538255
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66331405
39MYC_22102868_ChIP-Seq_BL_Human1.64293045
40BCL6_27268052_Chip-Seq_Bcells_Human1.63484368
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.63364188
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60315090
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57994242
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.57731369
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.57730502
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57414209
47* LXR_22292898_ChIP-Seq_THP-1_Human1.57387868
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54783448
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54783448
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54232171
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.54077876
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.54077876
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53945450
54* TP53_20018659_ChIP-ChIP_R1E_Mouse1.51232488
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50858630
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50561136
57FOXP1_21924763_ChIP-Seq_HESCs_Human1.50335979
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49483139
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49031529
60BCOR_27268052_Chip-Seq_Bcells_Human1.47965765
61PHF8_20622854_ChIP-Seq_HELA_Human1.47901996
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45920421
63MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.45195020
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45056004
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43156463
66CTCF_27219007_Chip-Seq_Bcells_Human1.42729753
67ETS1_20019798_ChIP-Seq_JURKAT_Human1.41926375
68SA1_27219007_Chip-Seq_Bcells_Human1.41883103
69STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.41762024
70* CTCF_21964334_Chip-Seq_Bcells_Human1.41483978
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41408267
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.40547744
73ATF3_27146783_Chip-Seq_COLON_Human1.39871256
74* CBX2_27304074_Chip-Seq_ESCs_Mouse1.39148974
75* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37437236
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36971147
77* NCOR1_26117541_ChIP-Seq_K562_Human1.36896852
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36889514
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36691917
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34602021
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33301734
82CTCF_26484167_Chip-Seq_Bcells_Mouse1.32430764
83KLF5_25053715_ChIP-Seq_YYC3_Human1.31056616
84CTCF_18555785_ChIP-Seq_MESCs_Mouse1.30723420
85* KDM2B_26808549_Chip-Seq_K562_Human1.30347056
86RARA_24833708_ChIP-Seq_LIVER_Mouse1.29769576
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28520854
88* KDM2B_26808549_Chip-Seq_DND41_Human1.28160611
89MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27900499
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.27546866
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26951133
92* TP63_22573176_ChIP-Seq_HFKS_Human1.25583048
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25298216
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25259371
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24202885
96TTF2_22483619_ChIP-Seq_HELA_Human1.22986133
97* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.22809292
98GABP_19822575_ChIP-Seq_HepG2_Human1.22500497
99* RUNX1_27514584_Chip-Seq_MCF-7_Human1.21949950
100CJUN_26792858_Chip-Seq_BT549_Human1.21673108
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20755936
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19621042
103KDM5A_27292631_Chip-Seq_BREAST_Human1.19390506
104MAF_26560356_Chip-Seq_TH2_Human1.18365377
105STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18059619
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17321432
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17028690
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16555263
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15347573
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14410218
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.13131530
112TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12825952
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.12329004
114UBF1/2_26484160_Chip-Seq_HMECs_Human1.11935335
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11782201
116* ISL1_27105846_Chip-Seq_CPCs_Mouse1.11287955
117CREB1_26743006_Chip-Seq_LNCaP_Human1.10434883
118SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10040084
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10009205
120ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09417362
121* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09400312
122* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09400312
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08061973
124ETS1_21867929_ChIP-Seq_TH2_Mouse1.07119951
125TCF7_22412390_ChIP-Seq_EML_Mouse1.06847882
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06556571
127DCP1A_22483619_ChIP-Seq_HELA_Human1.06148537
128ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06028496
129AR_21572438_ChIP-Seq_LNCaP_Human1.04949702
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04698190
131EED_16625203_ChIP-ChIP_MESCs_Mouse1.04055621
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04013789
133RNF2_27304074_Chip-Seq_ESCs_Mouse1.03839821
134KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03791448
135RAC3_21632823_ChIP-Seq_H3396_Human1.03472803
136P68_20966046_ChIP-Seq_HELA_Human1.03029507
137* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99947788
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99502054
139SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98977448
140P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.98963964
141* ERG_21242973_ChIP-ChIP_JURKAT_Human0.98927243
142* EZH2_27294783_Chip-Seq_ESCs_Mouse0.98688037
143JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97661371
144JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97233860
145EZH2_27304074_Chip-Seq_ESCs_Mouse0.97148082
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96996110
147* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96485923
148GATA3_24758297_ChIP-Seq_MCF-7_Human0.95457168
149CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94867874
150CTCF_20526341_ChIP-Seq_ESCs_Human0.94670035
151SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93663074
152SOX2_20726797_ChIP-Seq_SW620_Human0.93319142
153* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91583268
154ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89915389
155CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88354541
156* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88148017
157FOXH1_21741376_ChIP-Seq_ESCs_Human0.88128069
158CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87703676
159CDX2_20551321_ChIP-Seq_CACO-2_Human0.86765501
160E2F1_20622854_ChIP-Seq_HELA_Human0.86328415
161* RING1B_27294783_Chip-Seq_ESCs_Mouse0.85933716
162TP53_22127205_ChIP-Seq_IMR90_Human0.84030832
163THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83918607
164* SMC4_20622854_ChIP-Seq_HELA_Human0.82766279
165FOXM1_23109430_ChIP-Seq_U2OS_Human0.82203259
166* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82029766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.30761553
2MP0005275_abnormal_skin_tensile3.92382615
3MP0000579_abnormal_nail_morphology3.76123573
4MP0002796_impaired_skin_barrier3.74590925
5MP0004145_abnormal_muscle_electrophysio3.67231869
6MP0005451_abnormal_body_composition3.55236286
7MP0000751_myopathy3.41063621
8MP0010234_abnormal_vibrissa_follicle3.29136652
9MP0000749_muscle_degeneration3.21439769
10MP0010030_abnormal_orbit_morphology3.06407612
11MP0005410_abnormal_fertilization2.65056062
12MP0000762_abnormal_tongue_morphology2.63077382
13MP0005501_abnormal_skin_physiology2.62584524
14MP0002098_abnormal_vibrissa_morphology2.62474899
15MP0005670_abnormal_white_adipose2.50744633
16* MP0000678_abnormal_parathyroid_gland2.43325259
17MP0000383_abnormal_hair_follicle2.38103941
18MP0001849_ear_inflammation2.32287851
19MP0002060_abnormal_skin_morphology2.23875814
20* MP0000733_abnormal_muscle_development2.23359860
21MP0000647_abnormal_sebaceous_gland2.22099381
22MP0000467_abnormal_esophagus_morphology2.17275769
23MP0010678_abnormal_skin_adnexa2.16783289
24MP0000747_muscle_weakness2.15045801
25MP0002106_abnormal_muscle_physiology2.13523961
26* MP0000759_abnormal_skeletal_muscle2.11356182
27MP0003646_muscle_fatigue2.05533031
28MP0000750_abnormal_muscle_regeneration2.04609788
29MP0006036_abnormal_mitochondrial_physio1.95053812
30MP0004858_abnormal_nervous_system1.91777849
31MP0004036_abnormal_muscle_relaxation1.91355143
32MP0004087_abnormal_muscle_fiber1.90051127
33MP0000377_abnormal_hair_follicle1.89694684
34MP0000427_abnormal_hair_cycle1.87057524
35MP0001216_abnormal_epidermal_layer1.85710504
36MP0005369_muscle_phenotype1.82337495
37MP0005623_abnormal_meninges_morphology1.81228485
38MP0000003_abnormal_adipose_tissue1.73338004
39* MP0002234_abnormal_pharynx_morphology1.72362407
40MP0000537_abnormal_urethra_morphology1.69898191
41MP0008438_abnormal_cutaneous_collagen1.65902425
42MP0001243_abnormal_dermal_layer1.65659809
43MP0002269_muscular_atrophy1.63611762
44MP0010771_integument_phenotype1.63188522
45MP0003566_abnormal_cell_adhesion1.60120694
46MP0003453_abnormal_keratinocyte_physiol1.55284900
47MP0001346_abnormal_lacrimal_gland1.54496874
48MP0003941_abnormal_skin_development1.53541776
49MP0004185_abnormal_adipocyte_glucose1.51707607
50MP0002822_catalepsy1.50808573
51MP0002837_dystrophic_cardiac_calcinosis1.49468567
52MP0002132_abnormal_respiratory_system1.49332397
53MP0004272_abnormal_basement_membrane1.49225056
54MP0003693_abnormal_embryo_hatching1.45654368
55MP0001661_extended_life_span1.43981786
56* MP0002249_abnormal_larynx_morphology1.35551218
57MP0002108_abnormal_muscle_morphology1.33923810
58MP0003698_abnormal_male_reproductive1.33101827
59MP0002163_abnormal_gland_morphology1.31033391
60MP0005620_abnormal_muscle_contractility1.30747486
61MP0004130_abnormal_muscle_cell1.30176900
62MP0009250_abnormal_appendicular_skeleto1.28286269
63MP0002332_abnormal_exercise_endurance1.28079531
64MP0004233_abnormal_muscle_weight1.22661689
65MP0003111_abnormal_nucleus_morphology1.22563026
66MP0000013_abnormal_adipose_tissue1.22126994
67MP0004957_abnormal_blastocyst_morpholog1.21545026
68MP0002254_reproductive_system_inflammat1.18767926
69MP0002114_abnormal_axial_skeleton1.13307583
70MP0009053_abnormal_anal_canal1.12204824
71MP0010368_abnormal_lymphatic_system1.09534965
72MP0005076_abnormal_cell_differentiation1.07680270
73MP0001958_emphysema1.05847585
74* MP0000049_abnormal_middle_ear1.05154978
75MP0002160_abnormal_reproductive_system1.04778718
76MP0001929_abnormal_gametogenesis1.04737485
77MP0010352_gastrointestinal_tract_polyps1.03897213
78* MP0003755_abnormal_palate_morphology1.03549255
79MP0003385_abnormal_body_wall1.03548500
80MP0001299_abnormal_eye_distance/1.03271307
81MP0003045_fibrosis1.01689661
82MP0004484_altered_response_of1.01558995
83MP0009931_abnormal_skin_appearance1.01420187
84MP0003077_abnormal_cell_cycle1.01323921
85MP0005187_abnormal_penis_morphology0.99947574
86MP0005167_abnormal_blood-brain_barrier0.98084533
87MP0003137_abnormal_impulse_conducting0.98017725
88MP0005330_cardiomyopathy0.96930976
89* MP0008932_abnormal_embryonic_tissue0.94175094
90MP0004947_skin_inflammation0.93018625
91MP0002877_abnormal_melanocyte_morpholog0.92096219
92MP0002896_abnormal_bone_mineralization0.91718038
93MP0006054_spinal_hemorrhage0.90869842
94MP0000462_abnormal_digestive_system0.89773425
95MP0000367_abnormal_coat/_hair0.86504112
96MP0001188_hyperpigmentation0.86081707
97MP0000516_abnormal_urinary_system0.84908276
98MP0005367_renal/urinary_system_phenotyp0.84908276
99MP0002282_abnormal_trachea_morphology0.84800034
100MP0005666_abnormal_adipose_tissue0.84450777
101MP0010630_abnormal_cardiac_muscle0.83991190
102MP0003786_premature_aging0.83578367
103MP0008789_abnormal_olfactory_epithelium0.82970277
104MP0001730_embryonic_growth_arrest0.82641834
105MP0005503_abnormal_tendon_morphology0.82477925
106MP0005266_abnormal_metabolism0.82120148
107MP0002972_abnormal_cardiac_muscle0.81996336
108MP0002161_abnormal_fertility/fecundity0.81538420
109MP0005508_abnormal_skeleton_morphology0.79893151
110MP0005023_abnormal_wound_healing0.79506095
111MP0002233_abnormal_nose_morphology0.78856155
112MP0010094_abnormal_chromosome_stability0.76531319
113MP0009384_cardiac_valve_regurgitation0.74881198
114* MP0003935_abnormal_craniofacial_develop0.74517050
115MP0005375_adipose_tissue_phenotype0.72458076
116MP0001340_abnormal_eyelid_morphology0.72313549
117MP0000534_abnormal_ureter_morphology0.72132237
118MP0000432_abnormal_head_morphology0.71824692
119MP0000566_synostosis0.71487144
120* MP0002127_abnormal_cardiovascular_syste0.70646160
121MP0004084_abnormal_cardiac_muscle0.70211318
122MP0002210_abnormal_sex_determination0.70099559
123MP0001270_distended_abdomen0.69649995
124* MP0000681_abnormal_thyroid_gland0.69286636
125MP0002085_abnormal_embryonic_tissue0.68769857
126MP0000163_abnormal_cartilage_morphology0.68760761
127MP0002971_abnormal_brown_adipose0.67444080
128MP0002277_abnormal_respiratory_mucosa0.67019290
129MP0002697_abnormal_eye_size0.66445311
130MP0003937_abnormal_limbs/digits/tail_de0.65931502
131MP0005380_embryogenesis_phenotype0.65773360
132MP0001672_abnormal_embryogenesis/_devel0.65773360
133MP0005083_abnormal_biliary_tract0.63652060
134* MP0002932_abnormal_joint_morphology0.63169510
135MP0003315_abnormal_perineum_morphology0.62936421
136MP0009333_abnormal_splenocyte_physiolog0.62851127
137* MP0002116_abnormal_craniofacial_bone0.62827040
138MP0003942_abnormal_urinary_system0.62780323
139MP0000428_abnormal_craniofacial_morphol0.62648557
140MP0003279_aneurysm0.62579219
141MP0000266_abnormal_heart_morphology0.61405740
142MP0001348_abnormal_lacrimal_gland0.61302583
143MP0006138_congestive_heart_failure0.61188931
144MP0004782_abnormal_surfactant_physiolog0.60904090
145MP0003283_abnormal_digestive_organ0.60704960
146MP0000350_abnormal_cell_proliferation0.59794022
147MP0002080_prenatal_lethality0.59500994
148MP0001145_abnormal_male_reproductive0.59334830
149MP0001873_stomach_inflammation0.58290737
150MP0005385_cardiovascular_system_phenoty0.56759582
151MP0001544_abnormal_cardiovascular_syste0.56759582

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.46155615
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.28431310
3Type 1 muscle fiber predominance (HP:0003803)5.98815701
4Exercise-induced myalgia (HP:0003738)5.81058519
5Nemaline bodies (HP:0003798)5.67691490
6Distal arthrogryposis (HP:0005684)5.30736546
7Round ear (HP:0100830)5.28811429
8Exercise-induced muscle cramps (HP:0003710)5.13429744
9Myopathic facies (HP:0002058)4.73005918
10Increased connective tissue (HP:0009025)4.54129390
11Difficulty running (HP:0009046)4.53084955
12Onycholysis (HP:0001806)4.38806354
13Milia (HP:0001056)4.33311339
14Hypotrichosis (HP:0001006)4.33179282
15Ulnar deviation of the wrist (HP:0003049)4.28117077
16Muscle hypertrophy of the lower extremities (HP:0008968)4.23160625
17Muscle fiber splitting (HP:0003555)3.98554425
18Fragile nails (HP:0001808)3.97456904
19Hyporeflexia of lower limbs (HP:0002600)3.96358327
20Atrophic scars (HP:0001075)3.95646472
21Calcaneovalgus deformity (HP:0001848)3.94844380
22Calf muscle hypertrophy (HP:0008981)3.81150516
23Woolly hair (HP:0002224)3.77590317
24Centrally nucleated skeletal muscle fibers (HP:0003687)3.73596674
25Pili torti (HP:0003777)3.73015024
26Absent phalangeal crease (HP:0006109)3.71723545
27Deformed tarsal bones (HP:0008119)3.58986518
28Abnormality of skeletal muscle fiber size (HP:0012084)3.51401035
29Difficulty climbing stairs (HP:0003551)3.51138252
30Right ventricular cardiomyopathy (HP:0011663)3.47893759
31Increased variability in muscle fiber diameter (HP:0003557)3.47865582
32Bulbar palsy (HP:0001283)3.46746395
33Myoglobinuria (HP:0002913)3.24150955
34Plantar hyperkeratosis (HP:0007556)3.15221617
35EMG: myopathic abnormalities (HP:0003458)3.13132201
36Fatigable weakness (HP:0003473)3.12896871
37Abnormality of the neuromuscular junction (HP:0003398)3.12896871
38Abnormality of the calf musculature (HP:0001430)3.12783039
39Mildly elevated creatine phosphokinase (HP:0008180)3.12393139
40Abnormal finger flexion creases (HP:0006143)3.09677102
41Distal lower limb muscle weakness (HP:0009053)3.08915840
42Progressive muscle weakness (HP:0003323)3.05132716
43Muscle stiffness (HP:0003552)3.05064262
44Distal lower limb amyotrophy (HP:0008944)2.89059998
45Neck muscle weakness (HP:0000467)2.84984028
46Myotonia (HP:0002486)2.83791818
47Abnormality of the calcaneus (HP:0008364)2.82962025
48Pelvic girdle muscle weakness (HP:0003749)2.74929492
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70165364
50Shoulder girdle muscle weakness (HP:0003547)2.70117723
51Malignant hyperthermia (HP:0002047)2.69494497
52Spinal rigidity (HP:0003306)2.65557055
53Septate vagina (HP:0001153)2.64812302
54Abnormality of the musculature of the pelvis (HP:0001469)2.56866951
55Abnormality of the hip-girdle musculature (HP:0001445)2.56866951
56Protrusio acetabuli (HP:0003179)2.55012437
57Ragged-red muscle fibers (HP:0003200)2.54812504
58* Truncus arteriosus (HP:0001660)2.54721832
59Male infertility (HP:0003251)2.54650423
60Nail dystrophy (HP:0008404)2.53526486
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.49585569
62Absent/shortened dynein arms (HP:0200106)2.49585569
63Shallow orbits (HP:0000586)2.47894303
64Premature rupture of membranes (HP:0001788)2.46164944
65Slender build (HP:0001533)2.40787977
66Achilles tendon contracture (HP:0001771)2.38136851
67Rhabdomyolysis (HP:0003201)2.37974968
68Rimmed vacuoles (HP:0003805)2.36342325
69Increased IgE level (HP:0003212)2.36084844
70Broad distal phalanx of finger (HP:0009836)2.35527416
71Scapular winging (HP:0003691)2.32621268
72Fragile skin (HP:0001030)2.32518598
73Frequent falls (HP:0002359)2.31568186
74Alopecia of scalp (HP:0002293)2.27125381
75Bell-shaped thorax (HP:0001591)2.26951456
76Muscle fiber atrophy (HP:0100295)2.25554674
77Limb-girdle muscle atrophy (HP:0003797)2.24463737
78Lower limb amyotrophy (HP:0007210)2.22121912
79Nasal polyposis (HP:0100582)2.21540873
80Limb-girdle muscle weakness (HP:0003325)2.20873281
81Abnormality of the phalanges of the hallux (HP:0010057)2.20623284
82Abnormality of nail color (HP:0100643)2.20210217
83Palmoplantar hyperkeratosis (HP:0000972)2.18610868
84Broad metatarsal (HP:0001783)2.16680820
85Sudden death (HP:0001699)2.13550987
86Hypoplastic ischia (HP:0003175)2.11265769
87Oral leukoplakia (HP:0002745)2.10560804
88Abnormality of the Achilles tendon (HP:0005109)2.09428330
89Rectal prolapse (HP:0002035)2.09252524
90Advanced eruption of teeth (HP:0006288)2.06501056
91Fetal akinesia sequence (HP:0001989)2.05508088
92Thick nail (HP:0001805)2.03932794
93Areflexia of lower limbs (HP:0002522)2.03455889
94Palmar hyperkeratosis (HP:0010765)2.02295176
95Short middle phalanx of the 5th finger (HP:0004220)2.02114679
96Exercise intolerance (HP:0003546)2.00326621
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00157227
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99921491
99Ventricular tachycardia (HP:0004756)1.99357384
100Abnormal hair laboratory examination (HP:0003328)1.99101551
101Abnormality of the nasal mucosa (HP:0000433)1.98890408
102Increased muscle lipid content (HP:0009058)1.98520581
103Follicular hyperkeratosis (HP:0007502)1.98189009
104Hyperkalemia (HP:0002153)1.97609716
105Abnormality of the fetal cardiovascular system (HP:0010948)1.96764625
106Abnormal umbilical cord blood vessels (HP:0011403)1.96764625
107Single umbilical artery (HP:0001195)1.96764625
108Breast hypoplasia (HP:0003187)1.95935183
109Abnormal respiratory motile cilium physiology (HP:0012261)1.95423645
110* Transposition of the great arteries (HP:0001669)1.95142423
111* Abnormal connection of the cardiac segments (HP:0011545)1.95142423
112* Abnormal ventriculo-arterial connection (HP:0011563)1.95142423
113Subaortic stenosis (HP:0001682)1.93977666
114Abnormality of the left ventricular outflow tract (HP:0011103)1.93977666
115Conjunctival hamartoma (HP:0100780)1.93701895
116Abnormality of the umbilical cord (HP:0010881)1.91043314
117Abnormal respiratory epithelium morphology (HP:0012253)1.90828480
118Abnormal respiratory motile cilium morphology (HP:0005938)1.90828480
119Abnormality of the shoulder girdle musculature (HP:0001435)1.89841020
120Birth length less than 3rd percentile (HP:0003561)1.89448092
121Microretrognathia (HP:0000308)1.89432264
122Ankle contracture (HP:0006466)1.89398980
123Down-sloping shoulders (HP:0200021)1.89203723
124Increased intramyocellular lipid droplets (HP:0012240)1.88614549
125Cerebral aneurysm (HP:0004944)1.88082661
126Generalized muscle weakness (HP:0003324)1.86361091
127Facial diplegia (HP:0001349)1.84308316
128Bundle branch block (HP:0011710)1.83272142
129Stridor (HP:0010307)1.82000938
130Occipital encephalocele (HP:0002085)1.81602884
131Asymmetric septal hypertrophy (HP:0001670)1.81310358
132* Periauricular skin pits (HP:0100277)1.80507205
133* Preauricular pit (HP:0004467)1.80507205
134Gowers sign (HP:0003391)1.79044566
135Ulnar bowing (HP:0003031)1.78450519
136Ulnar deviation of finger (HP:0009465)1.76166789
137Abnormality of the ischium (HP:0003174)1.75341399
138Testicular atrophy (HP:0000029)1.75139900
139Abnormal ciliary motility (HP:0012262)1.74887243
140Pterygium (HP:0001059)1.74033939
141Hip contracture (HP:0003273)1.73353078
142* Congenital malformation of the right heart (HP:0011723)1.71591038
143* Double outlet right ventricle (HP:0001719)1.71591038
144Wrist flexion contracture (HP:0001239)1.71114688
145Paralysis (HP:0003470)1.71111892
146EMG: neuropathic changes (HP:0003445)1.69937210
147Thin ribs (HP:0000883)1.69401165
148Abnormal mitochondria in muscle tissue (HP:0008316)1.68210399
149Popliteal pterygium (HP:0009756)1.67382867
150Redundant skin (HP:0001582)1.67259520
151Waddling gait (HP:0002515)1.65895307
152Infertility (HP:0000789)1.63778423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.52113841
2SMG14.63905419
3OBSCN4.38408519
4TRIB34.32988290
5VRK23.44198486
6EPHB22.92009343
7PHKG12.81801565
8PHKG22.81801565
9IRAK32.67578350
10PIK3CG2.65975278
11NME22.55014226
12EEF2K2.40224408
13EPHA22.26444364
14NME12.20385157
15PTK62.03319526
16MAP2K32.01782935
17PKN21.97805027
18PLK41.96484662
19RIPK11.88263380
20FER1.86606028
21TESK11.82644481
22TAF11.80554412
23MAP3K71.75247588
24DDR21.69598460
25MAPKAPK31.68579830
26KDR1.63824831
27MAP3K31.50766998
28TRPM71.49425258
29NEK11.42323926
30LATS11.38753642
31ICK1.36534528
32MAP3K101.35727919
33PAK41.34621616
34LRRK21.34505506
35CAMK1D1.32724125
36PDGFRA1.27463625
37SIK11.26837260
38DMPK1.25256428
39ILK1.24462239
40BMX1.23679547
41CDK71.21539431
42STK161.16541834
43EPHB11.13980002
44MAP2K11.09776226
45ERN11.08089071
46MAP2K21.07998935
47LATS21.07813177
48BRAF1.07219755
49BUB11.06785199
50RPS6KB21.05399805
51MAP2K61.00646727
52MAPKAPK50.99414439
53DYRK1B0.99173973
54CDK80.98455711
55ERBB30.96256194
56CHEK20.95869269
57CDK60.93223849
58PDPK10.91198101
59TAOK10.89461514
60PTK20.88042561
61FGFR10.85625097
62MAPK120.85545798
63PINK10.85249135
64PAK20.84854722
65TGFBR20.83935255
66MAP3K20.83213042
67IRAK20.82084590
68PDK30.82053944
69PDK40.82053944
70BRD40.80333861
71CSNK1G30.80226426
72STK240.79304864
73FGFR20.78147570
74MAP3K110.77550242
75MST1R0.75752158
76AKT20.75484987
77RPS6KA40.75442400
78AURKA0.73569126
79CSNK1A1L0.72165041
80PRPF4B0.70379614
81TTK0.70258565
82MOS0.68130163
83PRKD10.65754182
84PDK20.65299767
85STK30.65067851
86CDK90.63830472
87CDK40.63135910
88MAPK150.62843538
89CHEK10.62766108
90ARAF0.62548571
91BRSK10.60047625
92MET0.59923488
93MTOR0.59543874
94NTRK10.58397531
95STK40.54719021
96MAP2K40.53474353
97PAK60.51943775
98KSR20.49691156
99CDK20.49215735
100PRKAA20.48025448
101PRKD30.47980551
102DAPK10.47944055
103TAOK20.47366232
104ROCK10.46941049
105MUSK0.46231946
106CCNB10.45782307
107BCR0.45485595
108ABL20.44762131
109CAMK2G0.44342881
110STK380.44163520
111VRK10.43743523
112CDC70.43206971
113PIK3CA0.43117444
114CSNK1G10.42202060
115PRKD20.41595945
116MAP3K80.41490399
117CDK10.41451184
118FGFR40.41232105
119PTK2B0.41016389
120ATR0.40411912
121HIPK20.40025779
122GRK10.40001016
123ROCK20.39990948
124PDK10.39345088
125MAP3K10.38748401
126TGFBR10.38625652
127RPS6KL10.37329396
128RPS6KC10.37329396
129TYRO30.37209485
130MAPK110.36838171
131RPS6KA10.35655681
132GSK3A0.33952151
133PRKCI0.33811626
134NUAK10.33189063
135TIE10.33134499
136CDK120.32655362
137CAMK40.32175993
138MAPK100.31394778
139RET0.31212577
140MST40.29841096
141CAMK1G0.29520398
142PAK10.29109159
143PDGFRB0.28731395
144BCKDK0.28067415
145DAPK30.27856376
146MAP3K90.26409858
147MAPKAPK20.26311856
148ERBB20.26103708
149DYRK30.24310993
150STK100.23725298
151PRKAA10.22381066
152MARK20.21494781

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.55664040
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.52383950
3Basal cell carcinoma_Homo sapiens_hsa052173.01420239
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.67044493
5ECM-receptor interaction_Homo sapiens_hsa045122.58268358
6Ribosome_Homo sapiens_hsa030102.56321128
7Arginine and proline metabolism_Homo sapiens_hsa003302.51026950
8Focal adhesion_Homo sapiens_hsa045102.36618158
9Dilated cardiomyopathy_Homo sapiens_hsa054142.33958571
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.24206642
11Adherens junction_Homo sapiens_hsa045202.21687148
12Biosynthesis of amino acids_Homo sapiens_hsa012302.13236454
13Tight junction_Homo sapiens_hsa045302.08566222
14DNA replication_Homo sapiens_hsa030302.06677369
15Proteoglycans in cancer_Homo sapiens_hsa052051.95597008
16Hedgehog signaling pathway_Homo sapiens_hsa043401.81903591
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80611328
18Hippo signaling pathway_Homo sapiens_hsa043901.80032651
19Base excision repair_Homo sapiens_hsa034101.78682735
20Huntingtons disease_Homo sapiens_hsa050161.66500411
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.65803806
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.65233233
23Insulin resistance_Homo sapiens_hsa049311.63308625
24Insulin signaling pathway_Homo sapiens_hsa049101.61617817
25Amoebiasis_Homo sapiens_hsa051461.60677420
26Glucagon signaling pathway_Homo sapiens_hsa049221.60264373
27Bladder cancer_Homo sapiens_hsa052191.59384448
28Oxytocin signaling pathway_Homo sapiens_hsa049211.55957339
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.53474608
30VEGF signaling pathway_Homo sapiens_hsa043701.53367132
31Pentose phosphate pathway_Homo sapiens_hsa000301.51026620
32Fructose and mannose metabolism_Homo sapiens_hsa000511.49140911
33Pyrimidine metabolism_Homo sapiens_hsa002401.48580986
34Notch signaling pathway_Homo sapiens_hsa043301.48473722
35Oxidative phosphorylation_Homo sapiens_hsa001901.47635477
36Parkinsons disease_Homo sapiens_hsa050121.46908137
37Melanogenesis_Homo sapiens_hsa049161.45904528
38Small cell lung cancer_Homo sapiens_hsa052221.42804045
39TGF-beta signaling pathway_Homo sapiens_hsa043501.42628333
40One carbon pool by folate_Homo sapiens_hsa006701.42105410
41Wnt signaling pathway_Homo sapiens_hsa043101.38540104
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.35900022
43Arginine biosynthesis_Homo sapiens_hsa002201.35643118
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34784329
45Alzheimers disease_Homo sapiens_hsa050101.34698395
46Protein digestion and absorption_Homo sapiens_hsa049741.32485870
47Cardiac muscle contraction_Homo sapiens_hsa042601.32420711
48Pyruvate metabolism_Homo sapiens_hsa006201.32287294
49Chronic myeloid leukemia_Homo sapiens_hsa052201.28196832
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.27694975
51RNA transport_Homo sapiens_hsa030131.27456804
52Fat digestion and absorption_Homo sapiens_hsa049751.26042916
53GnRH signaling pathway_Homo sapiens_hsa049121.25753904
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.24909122
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24345503
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23511785
57Homologous recombination_Homo sapiens_hsa034401.22664406
58Adipocytokine signaling pathway_Homo sapiens_hsa049201.22483360
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21916955
60Axon guidance_Homo sapiens_hsa043601.21228327
61Glioma_Homo sapiens_hsa052141.20847824
62Purine metabolism_Homo sapiens_hsa002301.20311980
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19799493
64RNA polymerase_Homo sapiens_hsa030201.19623021
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18735903
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17925248
67Nucleotide excision repair_Homo sapiens_hsa034201.15473199
68AMPK signaling pathway_Homo sapiens_hsa041521.15281913
69Central carbon metabolism in cancer_Homo sapiens_hsa052301.14971802
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14785413
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12245616
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12095053
73cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11829500
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11822637
75Spliceosome_Homo sapiens_hsa030401.10553873
76Mismatch repair_Homo sapiens_hsa034301.10514319
77Salivary secretion_Homo sapiens_hsa049701.09495041
78Gastric acid secretion_Homo sapiens_hsa049711.08962274
79Fanconi anemia pathway_Homo sapiens_hsa034601.02241019
80Platelet activation_Homo sapiens_hsa046111.01339263
81Vitamin B6 metabolism_Homo sapiens_hsa007501.00297930
82Estrogen signaling pathway_Homo sapiens_hsa049150.98250774
83Lysine degradation_Homo sapiens_hsa003100.96525997
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95573449
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94295670
86MicroRNAs in cancer_Homo sapiens_hsa052060.93643612
87Thyroid cancer_Homo sapiens_hsa052160.93294527
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92947737
89Renal cell carcinoma_Homo sapiens_hsa052110.91883970
90Pathways in cancer_Homo sapiens_hsa052000.91740170
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90984439
92Viral myocarditis_Homo sapiens_hsa054160.85165974
93mTOR signaling pathway_Homo sapiens_hsa041500.83482798
94Rap1 signaling pathway_Homo sapiens_hsa040150.83216030
95Endometrial cancer_Homo sapiens_hsa052130.82394247
96Glutathione metabolism_Homo sapiens_hsa004800.81131762
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81042562
98Galactose metabolism_Homo sapiens_hsa000520.80070741
99FoxO signaling pathway_Homo sapiens_hsa040680.79669134
100Renin secretion_Homo sapiens_hsa049240.78640044
101Toxoplasmosis_Homo sapiens_hsa051450.78242808
102Acute myeloid leukemia_Homo sapiens_hsa052210.76705091
103HIF-1 signaling pathway_Homo sapiens_hsa040660.75434189
104Dorso-ventral axis formation_Homo sapiens_hsa043200.73736564
105HTLV-I infection_Homo sapiens_hsa051660.73378992
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72899968
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71663637
108mRNA surveillance pathway_Homo sapiens_hsa030150.71019780
109Tyrosine metabolism_Homo sapiens_hsa003500.70758510
110Phenylalanine metabolism_Homo sapiens_hsa003600.70692971
111Starch and sucrose metabolism_Homo sapiens_hsa005000.69241361
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.68845531
113Fatty acid degradation_Homo sapiens_hsa000710.67585261
114Fatty acid biosynthesis_Homo sapiens_hsa000610.67372312
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65995710
116Cell cycle_Homo sapiens_hsa041100.65770157
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65490448
118Prostate cancer_Homo sapiens_hsa052150.65432056
119Sulfur metabolism_Homo sapiens_hsa009200.64744420
120Melanoma_Homo sapiens_hsa052180.64453154
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61594813
122Calcium signaling pathway_Homo sapiens_hsa040200.60783296
123Metabolic pathways_Homo sapiens_hsa011000.60518179
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58904276
125Basal transcription factors_Homo sapiens_hsa030220.57938513
126Circadian rhythm_Homo sapiens_hsa047100.57620587
127MAPK signaling pathway_Homo sapiens_hsa040100.57426654
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56379242
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56190356
130Linoleic acid metabolism_Homo sapiens_hsa005910.56119425
131Non-small cell lung cancer_Homo sapiens_hsa052230.55893422
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55756019
133Ras signaling pathway_Homo sapiens_hsa040140.54978022
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54874059
135Colorectal cancer_Homo sapiens_hsa052100.54779806
136Pancreatic cancer_Homo sapiens_hsa052120.53549690
137Carbon metabolism_Homo sapiens_hsa012000.53328192
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.52905777
139PPAR signaling pathway_Homo sapiens_hsa033200.52415141
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52290002
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51832036
142Salmonella infection_Homo sapiens_hsa051320.50812328
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48872678
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48829846
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45837498
146Gap junction_Homo sapiens_hsa045400.45781957
147Fatty acid metabolism_Homo sapiens_hsa012120.43652523
148Prolactin signaling pathway_Homo sapiens_hsa049170.43316700
149p53 signaling pathway_Homo sapiens_hsa041150.39816920
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.39736957
151Propanoate metabolism_Homo sapiens_hsa006400.39625956
152Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38737973
153Apoptosis_Homo sapiens_hsa042100.38373917
154Endocytosis_Homo sapiens_hsa041440.37277273
155Olfactory transduction_Homo sapiens_hsa047400.36776282
156Oocyte meiosis_Homo sapiens_hsa041140.36415896
157Folate biosynthesis_Homo sapiens_hsa007900.35942258
158Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31670025
159Fatty acid elongation_Homo sapiens_hsa000620.30247101
160Selenocompound metabolism_Homo sapiens_hsa004500.25535807

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