TBX10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the T-box family of transcription factors. These transcription factors share a DNA-binding domain called the T-box, and play a role in several developmental processes including early embryonic cell fate and organogenesis. The encoded protein is a member of the T-box 1 subfamily. Mutations in this gene are thought to be a cause of isolated cleft lip with or without cleft palate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)8.15467568
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.41902924
3drug transmembrane transport (GO:0006855)7.27363257
4intestinal absorption (GO:0050892)6.75216284
5very-low-density lipoprotein particle assembly (GO:0034379)6.74006220
6urate metabolic process (GO:0046415)6.60788758
7NADH metabolic process (GO:0006734)6.34381283
8axon ensheathment in central nervous system (GO:0032291)6.32910477
9central nervous system myelination (GO:0022010)6.32910477
10regulation of bile acid biosynthetic process (GO:0070857)6.25419720
11plasma lipoprotein particle assembly (GO:0034377)6.22796833
12drug transport (GO:0015893)5.92903014
13aminoglycoside antibiotic metabolic process (GO:0030647)5.92398525
14regulation of guanylate cyclase activity (GO:0031282)5.82658104
15phosphate ion transport (GO:0006817)5.79988632
16exogenous drug catabolic process (GO:0042738)5.75848166
17protein-lipid complex assembly (GO:0065005)5.54235071
18L-phenylalanine catabolic process (GO:0006559)5.52427197
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.52427197
20lipoprotein transport (GO:0042953)5.49990433
21cysteine metabolic process (GO:0006534)5.47725251
22organic cation transport (GO:0015695)5.43642912
23phosphate ion transmembrane transport (GO:0035435)5.42021205
24fructose metabolic process (GO:0006000)5.38434000
25glyoxylate metabolic process (GO:0046487)5.32068140
26phosphate ion homeostasis (GO:0055062)5.29913188
27trivalent inorganic anion homeostasis (GO:0072506)5.29913188
28epoxygenase P450 pathway (GO:0019373)5.24272136
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.23540711
30fat-soluble vitamin biosynthetic process (GO:0042362)5.21850353
31drug catabolic process (GO:0042737)5.21096701
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.17069270
33L-phenylalanine metabolic process (GO:0006558)5.17069270
34diacylglycerol metabolic process (GO:0046339)5.10085157
35regulation of cholesterol homeostasis (GO:2000188)5.01320011
36regulation of cholesterol esterification (GO:0010872)4.93423488
37regulation of systemic arterial blood pressure by hormone (GO:0001990)4.80812281
38regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.80812281
39endocrine process (GO:0050886)4.80812281
40low-density lipoprotein particle remodeling (GO:0034374)4.78368923
41high-density lipoprotein particle remodeling (GO:0034375)4.77514182
42response to lead ion (GO:0010288)4.74106892
43lysine metabolic process (GO:0006553)4.71106578
44lysine catabolic process (GO:0006554)4.71106578
45aspartate family amino acid catabolic process (GO:0009068)4.65410326
46plasma lipoprotein particle organization (GO:0071827)4.63147865
47maintenance of gastrointestinal epithelium (GO:0030277)4.62027336
48proline biosynthetic process (GO:0006561)4.60514510
49plasma lipoprotein particle remodeling (GO:0034369)4.54952518
50protein-lipid complex remodeling (GO:0034368)4.54952518
51macromolecular complex remodeling (GO:0034367)4.54952518
52vitamin transmembrane transport (GO:0035461)4.51919370
53response to mercury ion (GO:0046689)4.51099567
54nonribosomal peptide biosynthetic process (GO:0019184)4.47572862
55response to methylmercury (GO:0051597)4.45998382
56myelin maintenance (GO:0043217)4.45890331
57phospholipid efflux (GO:0033700)4.41129072
58protein-lipid complex subunit organization (GO:0071825)4.35426235
59positive regulation of guanylate cyclase activity (GO:0031284)4.31921169
60regulation of systemic arterial blood pressure (GO:0003073)4.30829352
61reverse cholesterol transport (GO:0043691)4.30004770
62quaternary ammonium group transport (GO:0015697)4.26033969
63urea cycle (GO:0000050)4.24281483
64glutathione biosynthetic process (GO:0006750)4.21980964
65amyloid precursor protein metabolic process (GO:0042982)4.17101282
66regulation of triglyceride catabolic process (GO:0010896)4.16104677
67glycosphingolipid catabolic process (GO:0046479)4.07895931
68lipoprotein metabolic process (GO:0042157)4.06412014
69urea metabolic process (GO:0019627)3.98034294
70aromatic amino acid family catabolic process (GO:0009074)3.97892229
71glycolipid catabolic process (GO:0019377)3.97044762
72positive regulation of triglyceride lipase activity (GO:0061365)3.96869134
73positive regulation of lipoprotein lipase activity (GO:0051006)3.96869134
74glutamine family amino acid biosynthetic process (GO:0009084)3.88503025
75carnitine metabolic process (GO:0009437)3.88102828
76short-chain fatty acid metabolic process (GO:0046459)3.86440812
77sodium-independent organic anion transport (GO:0043252)3.83152366
78bile acid and bile salt transport (GO:0015721)3.77183944
79renal system process involved in regulation of blood volume (GO:0001977)3.72680301
80serine family amino acid metabolic process (GO:0009069)3.72318009
81response to phenylpropanoid (GO:0080184)3.70142708
82amino-acid betaine metabolic process (GO:0006577)3.69477963
83homocysteine metabolic process (GO:0050667)3.68873777
84cholesterol efflux (GO:0033344)3.68482825
85fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.68153175
86cholesterol homeostasis (GO:0042632)3.67120981
87nitrogen cycle metabolic process (GO:0071941)3.65507060
88regulation of cholesterol metabolic process (GO:0090181)3.64999259
89serine family amino acid biosynthetic process (GO:0009070)3.64770793
90hormone catabolic process (GO:0042447)3.62488642
91drug metabolic process (GO:0017144)3.62278896
92glutathione derivative metabolic process (GO:1901685)3.61907357
93glutathione derivative biosynthetic process (GO:1901687)3.61907357
94sterol homeostasis (GO:0055092)3.61164664
95amyloid precursor protein catabolic process (GO:0042987)3.57609491
96renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.53302622
97epithelial structure maintenance (GO:0010669)3.52538739
98regulation of cGMP biosynthetic process (GO:0030826)3.50797179
99positive regulation of cellular amine metabolic process (GO:0033240)3.47997621
100GDP-mannose metabolic process (GO:0019673)3.47409664
101digestive system process (GO:0022600)3.45219590
102beta-amyloid metabolic process (GO:0050435)3.43270370
103female mating behavior (GO:0060180)3.36702610
104regulation of extracellular matrix disassembly (GO:0010715)3.36056586
105proline metabolic process (GO:0006560)3.35729572
106creatine metabolic process (GO:0006600)3.34788154
107regulation of female receptivity (GO:0045924)3.33279005
108nucleoside diphosphate biosynthetic process (GO:0009133)3.32748804
109myelination (GO:0042552)3.32674127
110ensheathment of neurons (GO:0007272)3.31816164
111axon ensheathment (GO:0008366)3.31816164
112aldehyde catabolic process (GO:0046185)3.31525926
113toxin transport (GO:1901998)3.31438876
114linoleic acid metabolic process (GO:0043651)3.30747994
115cellular modified amino acid catabolic process (GO:0042219)3.29303972
116oligosaccharide catabolic process (GO:0009313)3.28161805
117drinking behavior (GO:0042756)3.27727701
118arginine metabolic process (GO:0006525)3.27703537
119glutathione metabolic process (GO:0006749)3.25474342
120mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24136237
121positive regulation of lipid catabolic process (GO:0050996)3.23033599
122antibacterial humoral response (GO:0019731)3.22869004
123cellular anion homeostasis (GO:0030002)3.21195898
124ceramide catabolic process (GO:0046514)3.20683378
125intestinal cholesterol absorption (GO:0030299)3.17982597
126regulation of cellular extravasation (GO:0002691)3.17567537
127glucuronate metabolic process (GO:0019585)3.16439993
128uronic acid metabolic process (GO:0006063)3.16439993
129fatty acid beta-oxidation (GO:0006635)3.15221253
130peptide biosynthetic process (GO:0043043)3.13241130
131alpha-linolenic acid metabolic process (GO:0036109)3.12650128
132antimicrobial humoral response (GO:0019730)3.12481202
133dopamine biosynthetic process (GO:0042416)3.11996535
134bile acid metabolic process (GO:0008206)3.11279929
135peptide hormone processing (GO:0016486)3.11182703
136cellular glucuronidation (GO:0052695)3.10358797
137serine family amino acid catabolic process (GO:0009071)3.10255854
138L-ascorbic acid metabolic process (GO:0019852)3.09779157
139fatty acid oxidation (GO:0019395)3.05573006
140excretion (GO:0007588)3.04407393
141receptor guanylyl cyclase signaling pathway (GO:0007168)3.03863681
142ethanol metabolic process (GO:0006067)3.02385100
143negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.00909896
144vitamin transport (GO:0051180)3.00046916
145very long-chain fatty acid metabolic process (GO:0000038)2.99989203
146lipid oxidation (GO:0034440)2.99824334
147glutamate metabolic process (GO:0006536)2.99685768
148tricarboxylic acid metabolic process (GO:0072350)2.99442311
149carnitine transport (GO:0015879)2.98420006
150amino-acid betaine transport (GO:0015838)2.98420006
151virion attachment to host cell (GO:0019062)2.97523766
152adhesion of symbiont to host cell (GO:0044650)2.97523766
153positive regulation of fatty acid biosynthetic process (GO:0045723)2.96721156
154regulation of lipoprotein metabolic process (GO:0050746)2.93643600
155phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.93022991
156positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.92987669
157primary alcohol catabolic process (GO:0034310)2.92521769
158O-glycan processing (GO:0016266)2.91690616
159fatty acid elongation (GO:0030497)2.91623196
160digestion (GO:0007586)2.90978932
161positive regulation of pseudopodium assembly (GO:0031274)2.89649962
162branched-chain amino acid metabolic process (GO:0009081)2.86706280
163fatty acid catabolic process (GO:0009062)2.86693471
164long-chain fatty acid biosynthetic process (GO:0042759)2.86393695
165metanephric tubule development (GO:0072170)2.83031364
166metanephric nephron tubule development (GO:0072234)2.83031364
167peptide catabolic process (GO:0043171)2.82908234
168cellular amino acid catabolic process (GO:0009063)2.81102192
169mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.81072953
170flavonoid metabolic process (GO:0009812)2.80672624
171vitamin D metabolic process (GO:0042359)2.80322067
172aromatic amino acid family metabolic process (GO:0009072)2.80116261
173acetyl-CoA metabolic process (GO:0006084)2.79916304
174modified amino acid transport (GO:0072337)2.78906183
175metanephric nephron epithelium development (GO:0072243)2.78383718
176desmosome organization (GO:0002934)2.77692211
177cytoskeletal anchoring at plasma membrane (GO:0007016)2.76281336
178neurotransmitter biosynthetic process (GO:0042136)2.75771114
179sphingosine metabolic process (GO:0006670)2.74979420
180alpha-amino acid catabolic process (GO:1901606)2.74340210
181negative regulation of response to reactive oxygen species (GO:1901032)2.73880529
182tryptophan metabolic process (GO:0006568)2.71426099
183indole-containing compound catabolic process (GO:0042436)2.70886446
184indolalkylamine catabolic process (GO:0046218)2.70886446
185tryptophan catabolic process (GO:0006569)2.70886446
186ATP synthesis coupled proton transport (GO:0015986)2.65025909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.29279394
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.18241402
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.57384797
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.22966749
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.08879952
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.74901581
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.74845018
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.70848566
9ZNF263_19887448_ChIP-Seq_K562_Human2.69597366
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57951652
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.57278734
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.46714657
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.35615595
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32397634
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.08423276
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.02481206
17* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.92410283
18FOXA2_19822575_ChIP-Seq_HepG2_Human1.81941084
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.79382807
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74923931
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73980742
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.72343040
23HNF4A_19822575_ChIP-Seq_HepG2_Human1.67660910
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56997040
25KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56050931
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.53617877
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49589336
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48943283
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.48862661
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48173941
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.45638407
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45372138
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.44620564
34BCOR_27268052_Chip-Seq_Bcells_Human1.43480807
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41591391
36CREB1_26743006_Chip-Seq_LNCaP_Human1.41405912
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41227488
38* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40525456
39PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38290252
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37613501
41GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36958757
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34452873
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34412473
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32879065
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32290971
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31296570
47* RACK7_27058665_Chip-Seq_MCF-7_Human1.31177379
48P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30850416
49CLOCK_20551151_ChIP-Seq_293T_Human1.30282956
50LXR_22292898_ChIP-Seq_THP-1_Human1.29695850
51* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29647113
52RXR_22108803_ChIP-Seq_LS180_Human1.28163699
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.26317275
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.26269546
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25958239
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25851673
57* SA1_27219007_Chip-Seq_Bcells_Human1.24615224
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24319382
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23461945
60RARA_24833708_ChIP-Seq_LIVER_Mouse1.23110980
61BCL6_27268052_Chip-Seq_Bcells_Human1.22649118
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21383712
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20649808
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20242890
65SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19648867
66SCL_19346495_ChIP-Seq_HPC-7_Human1.19580685
67SOX2_20726797_ChIP-Seq_SW620_Human1.19293571
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14801604
69GATA4_25053715_ChIP-Seq_YYC3_Human1.14237166
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13870466
71NCOR1_26117541_ChIP-Seq_K562_Human1.13046857
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.12758528
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11814058
74TCF7_22412390_ChIP-Seq_EML_Mouse1.10604297
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09884995
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08975678
77P68_20966046_ChIP-Seq_HELA_Human1.08735868
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08384770
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08262599
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08143116
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08143116
82SMAD3_21741376_ChIP-Seq_HESCs_Human1.07871087
83JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.07602897
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07301800
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06721874
86MYC_22102868_ChIP-Seq_BL_Human1.06281585
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06050724
88JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05586280
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.04924182
90AR_21909140_ChIP-Seq_LNCAP_Human1.04709968
91SMC4_20622854_ChIP-Seq_HELA_Human1.04397034
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03863714
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03769594
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03453384
95* SA1_27219007_Chip-Seq_ERYTHROID_Human1.03253606
96GATA1_19941827_ChIP-Seq_MEL_Mouse1.03148001
97KLF5_25053715_ChIP-Seq_YYC3_Human1.02864450
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02732109
99GATA1_22025678_ChIP-Seq_K562_Human1.01299780
100* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01064218
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99232117
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98864384
103SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98554295
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98083319
105GBX2_23144817_ChIP-Seq_PC3_Human0.97896315
106GATA1_19941826_ChIP-Seq_K562_Human0.97008058
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97005633
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96838148
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96598128
110RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95200573
111GATA3_24758297_ChIP-Seq_MCF-7_Human0.95126897
112GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93981416
113TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93837007
114GATA2_19941826_ChIP-Seq_K562_Human0.93206402
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92452214
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92352884
117NANOG_19829295_ChIP-Seq_ESCs_Human0.92041803
118SOX2_19829295_ChIP-Seq_ESCs_Human0.92041803
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91286003
120* CTCF_27219007_Chip-Seq_Bcells_Human0.91239583
121TAF15_26573619_Chip-Seq_HEK293_Human0.90836026
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90650890
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89315009
124EZH2_27294783_Chip-Seq_ESCs_Mouse0.88997389
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88798938
126* ELK3_25401928_ChIP-Seq_HUVEC_Human0.88263152
127GATA1_26923725_Chip-Seq_HPCs_Mouse0.88186333
128TBX20_22328084_ChIP-Seq_HEART_Mouse0.88114391
129TBX20_22080862_ChIP-Seq_HEART_Mouse0.88114391
130VDR_24787735_ChIP-Seq_THP-1_Human0.87004838
131CTCF_20526341_ChIP-Seq_ESCs_Human0.86896144
132CSB_26484114_Chip-Seq_FIBROBLAST_Human0.86135535
133TP63_23658742_ChIP-Seq_EP156T_Human0.85679621
134BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.85449243
135NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85193863
136CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84950114
137PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84921473
138TET1_21451524_ChIP-Seq_MESCs_Mouse0.84431360
139SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83907996
140* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83123836
141JARID2_20064375_ChIP-Seq_MESCs_Mouse0.82272363
142GATA6_25053715_ChIP-Seq_YYC3_Human0.81994618
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81624409
144TAF2_19829295_ChIP-Seq_ESCs_Human0.80597625
145SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77887948
146TP63_22573176_ChIP-Seq_HFKS_Human0.77131004
147NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77084105
148DROSHA_22980978_ChIP-Seq_HELA_Human0.75829647
149HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75786984
150WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74098296
151EP300_21415370_ChIP-Seq_HL-1_Mouse0.73436860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.66389084
2MP0002139_abnormal_hepatobiliary_system4.60831552
3MP0004043_abnormal_pH_regulation4.04617593
4MP0003183_abnormal_peptide_metabolism3.78438663
5MP0004019_abnormal_vitamin_homeostasis3.63112219
6MP0003950_abnormal_plasma_membrane3.51167023
7MP0000920_abnormal_myelination3.48091409
8MP0004264_abnormal_extraembryonic_tissu3.47340427
9MP0003806_abnormal_nucleotide_metabolis3.42994107
10MP0005332_abnormal_amino_acid3.28333615
11MP0002138_abnormal_hepatobiliary_system3.03777183
12MP0005058_abnormal_lysosome_morphology2.87209619
13MP0008875_abnormal_xenobiotic_pharmacok2.81022721
14MP0005085_abnormal_gallbladder_physiolo2.74131720
15MP0009643_abnormal_urine_homeostasis2.47480610
16MP0010155_abnormal_intestine_physiology2.33960328
17MP0001765_abnormal_ion_homeostasis2.33190674
18MP0002796_impaired_skin_barrier2.33181044
19MP0003656_abnormal_erythrocyte_physiolo2.26922859
20MP0009379_abnormal_foot_pigmentation2.20702114
21MP0000678_abnormal_parathyroid_gland2.19568918
22MP0003195_calcinosis2.19325937
23MP0003690_abnormal_glial_cell2.17054898
24MP0005636_abnormal_mineral_homeostasis2.03329215
25MP0003252_abnormal_bile_duct1.96938827
26MP0001958_emphysema1.95465680
27MP0003868_abnormal_feces_composition1.94912481
28MP0003329_amyloid_beta_deposits1.85677939
29MP0002136_abnormal_kidney_physiology1.81847793
30MP0005451_abnormal_body_composition1.80715640
31MP0003866_abnormal_defecation1.78596538
32MP0006082_CNS_inflammation1.72930062
33MP0009840_abnormal_foam_cell1.65715913
34MP0003191_abnormal_cellular_cholesterol1.63439679
35MP0004858_abnormal_nervous_system1.63379793
36MP0005584_abnormal_enzyme/coenzyme_acti1.62287021
37MP0000490_abnormal_crypts_of1.60753799
38MP0000477_abnormal_intestine_morphology1.53469135
39MP0010352_gastrointestinal_tract_polyps1.53036872
40MP0005501_abnormal_skin_physiology1.52904927
41MP0002166_altered_tumor_susceptibility1.52241735
42MP0000604_amyloidosis1.51835782
43MP0010234_abnormal_vibrissa_follicle1.50828828
44MP0003186_abnormal_redox_activity1.49474356
45MP0001756_abnormal_urination1.43925036
46MP0005670_abnormal_white_adipose1.41830834
47MP0001764_abnormal_homeostasis1.38768159
48MP0000566_synostosis1.36019323
49MP0004885_abnormal_endolymph1.35954161
50MP0003879_abnormal_hair_cell1.30791517
51MP0003718_maternal_effect1.30781179
52MP0004185_abnormal_adipocyte_glucose1.30690656
53MP0003880_abnormal_central_pattern1.25832257
54MP0001873_stomach_inflammation1.25485579
55MP0005377_hearing/vestibular/ear_phenot1.25331705
56MP0003878_abnormal_ear_physiology1.25331705
57MP0000538_abnormal_urinary_bladder1.23921231
58MP0005464_abnormal_platelet_physiology1.23316008
59MP0003724_increased_susceptibility_to1.20945749
60MP0008872_abnormal_physiological_respon1.19162859
61MP0002132_abnormal_respiratory_system1.16307311
62MP0006054_spinal_hemorrhage1.15789523
63MP0002876_abnormal_thyroid_physiology1.12606419
64MP0005365_abnormal_bile_salt1.11777856
65MP0002118_abnormal_lipid_homeostasis1.11364242
66MP0000462_abnormal_digestive_system1.11227849
67MP0001485_abnormal_pinna_reflex1.09897683
68MP0005083_abnormal_biliary_tract1.08438627
69MP0005666_abnormal_adipose_tissue1.07802778
70MP0003075_altered_response_to1.04028293
71MP0004742_abnormal_vestibular_system1.02478148
72MP0005167_abnormal_blood-brain_barrier1.01285935
73MP0003283_abnormal_digestive_organ1.00996825
74MP0002822_catalepsy1.00350315
75MP0003634_abnormal_glial_cell1.00200175
76MP0000537_abnormal_urethra_morphology0.97081687
77MP0001663_abnormal_digestive_system0.96553714
78MP0005084_abnormal_gallbladder_morpholo0.94797669
79MP0000747_muscle_weakness0.94422471
80MP0004782_abnormal_surfactant_physiolog0.94410902
81MP0010329_abnormal_lipoprotein_level0.93501694
82MP0002098_abnormal_vibrissa_morphology0.91489557
83MP0002006_tumorigenesis0.91208974
84MP0003303_peritoneal_inflammation0.90255873
85MP0009642_abnormal_blood_homeostasis0.89780905
86MP0002229_neurodegeneration0.88193608
87MP0001905_abnormal_dopamine_level0.88036181
88MP0005448_abnormal_energy_balance0.87341169
89MP0004272_abnormal_basement_membrane0.86102841
90MP0005408_hypopigmentation0.85237445
91MP0000751_myopathy0.85119827
92MP0001666_abnormal_nutrient_absorption0.84133391
93MP0009115_abnormal_fat_cell0.82920549
94MP0005166_decreased_susceptibility_to0.82404305
95MP0002998_abnormal_bone_remodeling0.80256456
96MP0003633_abnormal_nervous_system0.78584761
97MP0000230_abnormal_systemic_arterial0.78455038
98MP0002089_abnormal_postnatal_growth/wei0.78442061
99MP0005319_abnormal_enzyme/_coenzyme0.78409888
100MP0003638_abnormal_response/metabolism_0.77303440
101MP0002332_abnormal_exercise_endurance0.76841660
102MP0002295_abnormal_pulmonary_circulatio0.75653663
103MP0000858_altered_metastatic_potential0.75409636
104MP0008961_abnormal_basal_metabolism0.74378339
105MP0002971_abnormal_brown_adipose0.73638135
106MP0003315_abnormal_perineum_morphology0.73006201
107MP0002064_seizures0.72260063
108MP0004270_analgesia0.68967128
109MP0009764_decreased_sensitivity_to0.67050995
110MP0001849_ear_inflammation0.67040557
111MP0010771_integument_phenotype0.66554836
112MP0003172_abnormal_lysosome_physiology0.65790875
113MP0004510_myositis0.65695596
114MP0002249_abnormal_larynx_morphology0.65503186
115MP0000609_abnormal_liver_physiology0.63259749
116MP0003221_abnormal_cardiomyocyte_apopto0.62623302
117MP0004147_increased_porphyrin_level0.62184475
118MP0005310_abnormal_salivary_gland0.62095989
119MP0008260_abnormal_autophagy0.61364742
120MP0006036_abnormal_mitochondrial_physio0.61095044
121MP0001188_hyperpigmentation0.60989091
122MP0005535_abnormal_body_temperature0.60517667
123MP0002078_abnormal_glucose_homeostasis0.59818513
124MP0008469_abnormal_protein_level0.59792755
125MP0003631_nervous_system_phenotype0.59427998
126MP0002272_abnormal_nervous_system0.59137892
127MP0000598_abnormal_liver_morphology0.59100762
128MP0003705_abnormal_hypodermis_morpholog0.58938417
129MP0005381_digestive/alimentary_phenotyp0.58763655
130MP0003953_abnormal_hormone_level0.58520797
131MP0005266_abnormal_metabolism0.57981461
132MP0009765_abnormal_xenobiotic_induced0.57293834
133MP0005409_darkened_coat_color0.56835326
134MP0008874_decreased_physiological_sensi0.56757074
135MP0003828_pulmonary_edema0.56200132
136MP0009780_abnormal_chondrocyte_physiolo0.55570241
137MP0005165_increased_susceptibility_to0.55284827
138MP0004947_skin_inflammation0.55024787
139MP0005376_homeostasis/metabolism_phenot0.54058358
140MP0005375_adipose_tissue_phenotype0.53998313
141MP0003300_gastrointestinal_ulcer0.53571760
142MP0001664_abnormal_digestion0.53133614
143MP0001851_eye_inflammation0.53068574
144MP0001963_abnormal_hearing_physiology0.51218192
145MP0008789_abnormal_olfactory_epithelium0.51180433
146MP0001845_abnormal_inflammatory_respons0.51053884
147MP0005257_abnormal_intraocular_pressure0.49283648
148MP0006138_congestive_heart_failure0.47989537
149MP0009333_abnormal_splenocyte_physiolog0.47135007
150MP0000534_abnormal_ureter_morphology0.45936897
151MP0000249_abnormal_blood_vessel0.45732617
152MP0003693_abnormal_embryo_hatching0.45505377
153MP0005334_abnormal_fat_pad0.44016565
154MP0000681_abnormal_thyroid_gland0.41700687
155MP0000516_abnormal_urinary_system0.40959717
156MP0005367_renal/urinary_system_phenotyp0.40959717
157MP0009931_abnormal_skin_appearance0.40196989

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)5.58909270
2Malnutrition (HP:0004395)5.02381216
3Acanthocytosis (HP:0001927)4.90485885
4Gout (HP:0001997)4.57248863
5Proximal tubulopathy (HP:0000114)4.53901027
6Delayed epiphyseal ossification (HP:0002663)4.42082333
7Metabolic alkalosis (HP:0200114)4.21474927
8Diaphragmatic weakness (HP:0009113)4.10140003
9Hypophosphatemic rickets (HP:0004912)4.07928603
10Thin bony cortex (HP:0002753)3.97419134
11Hypokalemic alkalosis (HP:0001949)3.96590263
12Fat malabsorption (HP:0002630)3.93637593
13Rickets (HP:0002748)3.88517437
14Neurofibrillary tangles (HP:0002185)3.88514909
15Hemorrhage of the eye (HP:0011885)3.88276725
16Hypomagnesemia (HP:0002917)3.87975142
17Deep venous thrombosis (HP:0002625)3.87841277
18Increased circulating renin level (HP:0000848)3.79925179
19Systemic lupus erythematosus (HP:0002725)3.79223565
20Abnormal urine phosphate concentration (HP:0012599)3.76943222
21Abnormality of monocarboxylic acid metabolism (HP:0010996)3.67534187
22Generalized aminoaciduria (HP:0002909)3.60585378
23Widely patent fontanelles and sutures (HP:0004492)3.56950525
24Polyuria (HP:0000103)3.55903194
25Flat occiput (HP:0005469)3.42495440
26Abnormal urine output (HP:0012590)3.41931293
27Abnormality of renal excretion (HP:0011036)3.40844342
28Chronic diarrhea (HP:0002028)3.39606895
29Nausea (HP:0002018)3.39570435
30Glycosuria (HP:0003076)3.36069671
31Abnormality of urine glucose concentration (HP:0011016)3.36069671
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.30992629
33Abnormality of the costochondral junction (HP:0000919)3.28915225
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.26186265
35Enlarged epiphyses (HP:0010580)3.22628907
36Hypolipoproteinemia (HP:0010981)3.19287174
37Abnormality of vitamin B metabolism (HP:0004340)3.16551592
38Abnormality of magnesium homeostasis (HP:0004921)3.14247638
39Hyperphosphaturia (HP:0003109)3.12707927
40Abnormal drinking behavior (HP:0030082)3.11448817
41Polydipsia (HP:0001959)3.11448817
42Cerebral inclusion bodies (HP:0100314)3.11122443
43Increased purine levels (HP:0004368)3.09854336
44Hyperuricemia (HP:0002149)3.09854336
45Abnormality of aromatic amino acid family metabolism (HP:0004338)3.08256152
46Abnormality of chloride homeostasis (HP:0011422)3.07095071
47Abnormality of glutamine family amino acid metabolism (HP:0010902)3.06074275
48Flat acetabular roof (HP:0003180)3.04242467
49Intrahepatic cholestasis (HP:0001406)3.03548453
50Menorrhagia (HP:0000132)3.03245314
51Hypercalciuria (HP:0002150)3.02938990
52Hyperactive renin-angiotensin system (HP:0000841)2.99234014
53Hyperlipoproteinemia (HP:0010980)2.99057641
54Abnormality of purine metabolism (HP:0004352)2.97814749
55Pigmentary retinal degeneration (HP:0001146)2.97213902
56Facial shape deformation (HP:0011334)2.95308118
57Potter facies (HP:0002009)2.95308118
58Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.95000931
59Abnormal enzyme/coenzyme activity (HP:0012379)2.93913487
60Petechiae (HP:0000967)2.92370735
61Hypophosphatemia (HP:0002148)2.89843128
62Abnormality of alkaline phosphatase activity (HP:0004379)2.88749380
63Axonal loss (HP:0003447)2.85948599
64Abnormal tarsal ossification (HP:0008369)2.85053669
65Hyperglycinuria (HP:0003108)2.84581103
66Decreased circulating renin level (HP:0003351)2.84451504
67Glomerulonephritis (HP:0000099)2.74053914
68Elevated alkaline phosphatase (HP:0003155)2.72771836
69Confusion (HP:0001289)2.69497933
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.69162522
71Abdominal distention (HP:0003270)2.68546221
72Abnormality of glycine metabolism (HP:0010895)2.64989479
73Abnormality of serine family amino acid metabolism (HP:0010894)2.64989479
74Alkalosis (HP:0001948)2.61937417
75Vacuolated lymphocytes (HP:0001922)2.61880376
76Distal lower limb muscle weakness (HP:0009053)2.60916972
77Xanthomatosis (HP:0000991)2.60302249
78Poikilocytosis (HP:0004447)2.59319502
79Prolonged neonatal jaundice (HP:0006579)2.54982531
80Ketosis (HP:0001946)2.53663511
81Epidermoid cyst (HP:0200040)2.53211887
82Megaloblastic anemia (HP:0001889)2.49218123
83Purpura (HP:0000979)2.47527034
84Complement deficiency (HP:0004431)2.38713366
85Nephrolithiasis (HP:0000787)2.38222793
86Right ventricular cardiomyopathy (HP:0011663)2.37176267
87Renal tubular dysfunction (HP:0000124)2.35909288
88Hypotension (HP:0002615)2.32518291
89Renal salt wasting (HP:0000127)2.31083853
90Ketoacidosis (HP:0001993)2.30531272
91Muscle fiber splitting (HP:0003555)2.29927682
92Hyperammonemia (HP:0001987)2.29785066
93Abnormality of renal resorption (HP:0011038)2.29531345
94Vascular calcification (HP:0004934)2.29257244
95Hyperaldosteronism (HP:0000859)2.26181043
96Renal tubular acidosis (HP:0001947)2.24541589
97Abnormality of methionine metabolism (HP:0010901)2.22895412
98Abnormality of complement system (HP:0005339)2.22411057
99Steatorrhea (HP:0002570)2.20030591
100Hyperparathyroidism (HP:0000843)2.19914721
101Loss of speech (HP:0002371)2.19826603
102Skin nodule (HP:0200036)2.18582662
103Abnormality of renin-angiotensin system (HP:0000847)2.16844221
104Cholecystitis (HP:0001082)2.16779348
105Abnormal gallbladder physiology (HP:0012438)2.16779348
106Abnormality of macrophages (HP:0004311)2.16285442
107Degeneration of the lateral corticospinal tracts (HP:0002314)2.15663284
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15663284
109Dicarboxylic aciduria (HP:0003215)2.15178069
110Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15178069
111High anterior hairline (HP:0009890)2.14566221
112Prolonged bleeding time (HP:0003010)2.14496035
113Wide cranial sutures (HP:0010537)2.14167755
114Prolonged partial thromboplastin time (HP:0003645)2.13859812
115Focal segmental glomerulosclerosis (HP:0000097)2.13599201
116Joint hemorrhage (HP:0005261)2.12440447
117Abnormality of carpal bone ossification (HP:0006257)2.11094234
118Gastrointestinal dysmotility (HP:0002579)2.10433308
119Metaphyseal irregularity (HP:0003025)2.08779994
120Hypercholesterolemia (HP:0003124)2.08170141
121Methylmalonic aciduria (HP:0012120)2.06346496
122Cardiovascular calcification (HP:0011915)2.03855014
123Delayed CNS myelination (HP:0002188)2.03548677
124Abnormality of nucleobase metabolism (HP:0010932)2.02506067
125Tetany (HP:0001281)2.00884765
126Segmental peripheral demyelination/remyelination (HP:0003481)2.00274826
127Progressive external ophthalmoplegia (HP:0000590)1.98337629
128Abnormality of fatty-acid metabolism (HP:0004359)1.97821974
129Ileus (HP:0002595)1.97483797
130Abnormality of the vitamin B12 metabolism (HP:0004341)1.97076679
131Seborrheic dermatitis (HP:0001051)1.95962760
132Glomerulosclerosis (HP:0000096)1.95670798
133Abnormal auditory evoked potentials (HP:0006958)1.94292616
134Nephritis (HP:0000123)1.94245485
135Hypoglycemic coma (HP:0001325)1.94228587
136Hyporeflexia of lower limbs (HP:0002600)1.94127005
137Abnormality of vitamin metabolism (HP:0100508)1.93392121
138Abnormality of the common coagulation pathway (HP:0010990)1.92364514
139Spastic tetraparesis (HP:0001285)1.90284337
140Onion bulb formation (HP:0003383)1.89522174
141Abnormal hair laboratory examination (HP:0003328)1.89485173
142Dry hair (HP:0011359)1.88974366
143Hypokalemia (HP:0002900)1.88247598
144Termporal pattern (HP:0011008)1.86160606
145Insidious onset (HP:0003587)1.86160606
146Abnormality of small intestinal villus morphology (HP:0011472)1.85959701
147Villous atrophy (HP:0011473)1.85959701
148Sensory axonal neuropathy (HP:0003390)1.84795717
149Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84577586
150Hydroxyprolinuria (HP:0003080)1.83360312
151Abnormality of proline metabolism (HP:0010907)1.83360312
152Protuberant abdomen (HP:0001538)1.80097120
153Abnormality of pyrimidine metabolism (HP:0004353)1.78844925
154Abnormal platelet function (HP:0011869)1.77213298
155Impaired platelet aggregation (HP:0003540)1.77213298
156Increased mean platelet volume (HP:0011877)1.74871611
157Vaginal fistula (HP:0004320)1.74178889
158Abnormal foot bone ossification (HP:0010675)1.73843017
159Ankle clonus (HP:0011448)1.72617031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR15.19836134
2WNK45.12723770
3STK394.68111743
4ACVR1B4.65076456
5EPHA23.64595876
6RIPK12.89282877
7GRK72.76143964
8PKN22.73965510
9STK102.66284592
10MST42.65468350
11PRKG22.64324217
12TRIB32.61911250
13TGFBR22.59056873
14BCKDK2.58822121
15SIK12.52555886
16EPHB12.51100467
17WNK32.29056620
18CLK12.19687035
19MAP3K102.11744345
20LMTK22.05725891
21ICK2.03391109
22CDK192.00613524
23MOS1.83546983
24CDK121.82602480
25FGFR31.80665887
26PBK1.73356962
27MAP3K111.67079015
28MAPKAPK51.64584335
29MAPK151.60998975
30NME21.55944519
31PIK3CA1.48572231
32WNK11.47614849
33ABL21.42315892
34PRKCI1.40084265
35PKN11.39539315
36DAPK21.37353059
37MARK11.37121045
38PTK21.34839979
39BCR1.34313834
40LRRK21.33765433
41MAP3K21.28608979
42MET1.17530941
43TESK21.15753878
44EEF2K1.15748972
45AKT31.10051601
46MAP3K91.07929327
47GRK51.06639678
48MST1R1.06165504
49PDGFRA1.04930756
50MATK1.03357962
51TESK11.03039890
52NTRK11.02829041
53NME11.02256582
54KSR21.01755600
55RET1.01047643
56MAP3K81.00615505
57BRSK20.99173192
58SMG10.92168531
59PTK60.90717254
60MAP3K10.88889819
61STK110.88503964
62ERN10.85206483
63MAPK110.84381182
64CAMK2B0.84336906
65TAOK10.84303694
66EPHA30.83611753
67ERBB20.82715601
68CDC42BPA0.81468716
69CSNK1G10.79830450
70JAK20.79302802
71TYRO30.79160615
72ADRBK10.79090543
73GSK3A0.77970725
74MAP2K60.75422372
75GRK60.75328670
76PDK30.74214201
77PDK40.74214201
78TYK20.73379313
79ROCK20.69071136
80PAK20.68924608
81TLK10.68374872
82MAP2K20.65467514
83CSNK1G30.64787437
84KDR0.64421255
85PRKCQ0.63720356
86PTK2B0.63559250
87EPHB20.63073712
88PRKCH0.61659054
89UHMK10.61500269
90PRKACG0.60795223
91PRKAA20.60464302
92RIPK40.60091795
93FER0.59894512
94CDK70.59730000
95MYLK0.59330661
96STK240.58566672
97ADRBK20.58070693
98PAK40.57468334
99CDK140.57324732
100PRKACB0.55863748
101IRAK30.54574709
102SGK4940.53780055
103SGK2230.53780055
104CDK150.53312364
105EIF2AK10.52505996
106PDPK10.52261101
107PDK20.51806081
108LIMK10.51740463
109BMX0.51012814
110FGFR40.49669356
111INSR0.48969166
112ALK0.46771217
113CSNK1A1L0.46173044
114CDK180.45931738
115BTK0.45485571
116ARAF0.45133143
117PRKCE0.44708523
118CSNK1D0.43851234
119CAMK2D0.43716238
120PRKD10.43487645
121CDK50.43262508
122EIF2AK20.43125911
123IKBKB0.42861347
124DYRK1B0.42700240
125CDK11A0.42546326
126CAMK2G0.40698910
127PRKCZ0.40027078
128ILK0.39795523
129FGFR20.39674256
130TNIK0.38761091
131ITK0.38525321
132PRKCD0.38082519
133CAMKK20.38004400
134FGFR10.37511364
135HCK0.36866959
136TEC0.36816268
137CSNK1G20.36799433
138FYN0.36328592
139PDK10.36207154
140MAP4K10.36027614
141FGR0.34759609
142DDR20.34546533
143MAP3K130.33824251
144CSF1R0.33407123
145MAPKAPK30.33070244
146SRC0.31941436
147PRKCA0.30661795
148MTOR0.29556878
149SGK10.27925682
150PRKAA10.26160309
151MAPKAPK20.26051038
152CSNK1E0.25136107
153CSNK1A10.24844189
154TAOK30.20675530
155MAP3K30.18082441
156DMPK0.16071023
157BRSK10.16067567
158RPS6KA20.15333028
159MAPK30.14146989

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.59040392
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.54074983
3Renin-angiotensin system_Homo sapiens_hsa046143.49564906
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30815097
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.97697196
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64017350
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.47580769
8Fatty acid degradation_Homo sapiens_hsa000712.42532818
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40823741
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39931014
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.36157585
12Fatty acid elongation_Homo sapiens_hsa000622.32773488
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29840385
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.28999927
15Sulfur metabolism_Homo sapiens_hsa009202.03573725
16Oxidative phosphorylation_Homo sapiens_hsa001901.96186199
17Propanoate metabolism_Homo sapiens_hsa006401.90075480
18Fatty acid metabolism_Homo sapiens_hsa012121.89641391
19Caffeine metabolism_Homo sapiens_hsa002321.87961213
20Peroxisome_Homo sapiens_hsa041461.86720586
21Galactose metabolism_Homo sapiens_hsa000521.83583022
22Folate biosynthesis_Homo sapiens_hsa007901.76749482
23Histidine metabolism_Homo sapiens_hsa003401.75758265
24Steroid biosynthesis_Homo sapiens_hsa001001.74176639
25Glutathione metabolism_Homo sapiens_hsa004801.72881575
26Arginine and proline metabolism_Homo sapiens_hsa003301.72584699
27Pyruvate metabolism_Homo sapiens_hsa006201.69796242
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65240259
29Tryptophan metabolism_Homo sapiens_hsa003801.62881857
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51172896
31Bile secretion_Homo sapiens_hsa049761.50817370
32Collecting duct acid secretion_Homo sapiens_hsa049661.48478066
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45626672
34Parkinsons disease_Homo sapiens_hsa050121.44729669
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36884549
36beta-Alanine metabolism_Homo sapiens_hsa004101.34238616
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25021589
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21443600
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21138742
40PPAR signaling pathway_Homo sapiens_hsa033201.19774346
41Arginine biosynthesis_Homo sapiens_hsa002201.18919465
42Sphingolipid metabolism_Homo sapiens_hsa006001.17559849
43Fatty acid biosynthesis_Homo sapiens_hsa000611.15643175
44Vitamin digestion and absorption_Homo sapiens_hsa049771.15383264
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15382302
46Alzheimers disease_Homo sapiens_hsa050101.14317347
47Mineral absorption_Homo sapiens_hsa049781.09546829
48Carbon metabolism_Homo sapiens_hsa012001.08489093
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.06796853
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06321866
51Nitrogen metabolism_Homo sapiens_hsa009101.05148807
52Other glycan degradation_Homo sapiens_hsa005110.99416222
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98382913
54Chemical carcinogenesis_Homo sapiens_hsa052040.93074637
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92758911
56Starch and sucrose metabolism_Homo sapiens_hsa005000.91415801
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86944870
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85744341
59Lysosome_Homo sapiens_hsa041420.85298418
60Protein digestion and absorption_Homo sapiens_hsa049740.83816376
61Sulfur relay system_Homo sapiens_hsa041220.83388814
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80953465
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.80300716
64Cardiac muscle contraction_Homo sapiens_hsa042600.79586378
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79121681
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.78988234
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78527519
68Glycerolipid metabolism_Homo sapiens_hsa005610.72620028
69Phenylalanine metabolism_Homo sapiens_hsa003600.72411109
70Arachidonic acid metabolism_Homo sapiens_hsa005900.71831873
71Lysine degradation_Homo sapiens_hsa003100.71033722
72Fructose and mannose metabolism_Homo sapiens_hsa000510.70247546
73Biosynthesis of amino acids_Homo sapiens_hsa012300.70187808
74ABC transporters_Homo sapiens_hsa020100.69898978
75Ether lipid metabolism_Homo sapiens_hsa005650.67191994
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.65348932
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.62026038
78Huntingtons disease_Homo sapiens_hsa050160.59336286
79Metabolic pathways_Homo sapiens_hsa011000.59302719
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58829460
81Insulin resistance_Homo sapiens_hsa049310.57640019
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57275450
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53394912
84Retinol metabolism_Homo sapiens_hsa008300.49062967
85Rheumatoid arthritis_Homo sapiens_hsa053230.48536589
86Cocaine addiction_Homo sapiens_hsa050300.45636208
87Vibrio cholerae infection_Homo sapiens_hsa051100.44441852
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.42037627
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39809601
90Pentose phosphate pathway_Homo sapiens_hsa000300.39759818
91Glucagon signaling pathway_Homo sapiens_hsa049220.36757513
92Tyrosine metabolism_Homo sapiens_hsa003500.36560389
93Phagosome_Homo sapiens_hsa041450.35269812
94Tight junction_Homo sapiens_hsa045300.34133569
95Asthma_Homo sapiens_hsa053100.32751928
96Complement and coagulation cascades_Homo sapiens_hsa046100.31289435
97N-Glycan biosynthesis_Homo sapiens_hsa005100.30105070
98Gastric acid secretion_Homo sapiens_hsa049710.29835399
99Linoleic acid metabolism_Homo sapiens_hsa005910.29698978
100Protein export_Homo sapiens_hsa030600.29320312
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29248041
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.29094014
103AMPK signaling pathway_Homo sapiens_hsa041520.26443675
104Axon guidance_Homo sapiens_hsa043600.25248136
105Bladder cancer_Homo sapiens_hsa052190.24788431
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.24728017
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24229520
108Vitamin B6 metabolism_Homo sapiens_hsa007500.23636766
109Salivary secretion_Homo sapiens_hsa049700.22573449
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21146560
111Staphylococcus aureus infection_Homo sapiens_hsa051500.21046347
112Fat digestion and absorption_Homo sapiens_hsa049750.19623196
113Renin secretion_Homo sapiens_hsa049240.19194614
114Amphetamine addiction_Homo sapiens_hsa050310.18946829
115Thyroid hormone synthesis_Homo sapiens_hsa049180.17687916
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.16304702
117Insulin signaling pathway_Homo sapiens_hsa049100.14942581
118Synaptic vesicle cycle_Homo sapiens_hsa047210.12855033
119Choline metabolism in cancer_Homo sapiens_hsa052310.12059494
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.09628121
121Pancreatic secretion_Homo sapiens_hsa049720.09248107
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.07596583
123Hepatitis C_Homo sapiens_hsa051600.05243037
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.04474213
125Platelet activation_Homo sapiens_hsa046110.02716222
126Thyroid cancer_Homo sapiens_hsa052160.01824000
127Prostate cancer_Homo sapiens_hsa05215-0.0304879
128Endometrial cancer_Homo sapiens_hsa05213-0.0101320

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