TBX15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)8.79021964
2actin-myosin filament sliding (GO:0033275)8.79021964
3regulation of skeletal muscle contraction (GO:0014819)7.96445795
4actin-mediated cell contraction (GO:0070252)7.43710380
5skeletal muscle contraction (GO:0003009)7.18757460
6plasma membrane repair (GO:0001778)6.93810431
7skeletal muscle fiber development (GO:0048741)6.21212292
8regulation of relaxation of muscle (GO:1901077)6.15091423
9skeletal muscle adaptation (GO:0043501)5.98594561
10sarcoplasmic reticulum calcium ion transport (GO:0070296)5.88028668
11actin filament-based movement (GO:0030048)5.76069832
12collagen fibril organization (GO:0030199)5.53239587
13myotube cell development (GO:0014904)5.23086886
14bone trabecula formation (GO:0060346)4.92707224
15protein heterotrimerization (GO:0070208)4.90612567
16sequestering of extracellular ligand from receptor (GO:0035581)4.85863801
17chondrocyte proliferation (GO:0035988)4.83096701
18negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.68676811
19muscle organ morphogenesis (GO:0048644)4.63425676
20regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.58008324
21cardiac muscle contraction (GO:0060048)4.46056227
22sarcomere organization (GO:0045214)4.32544899
23mesenchymal-epithelial cell signaling (GO:0060638)4.31594924
24response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.28291536
25positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.28011195
26skeletal muscle tissue regeneration (GO:0043403)4.19356914
27glycogen biosynthetic process (GO:0005978)4.15852145
28glucan biosynthetic process (GO:0009250)4.15852145
29myofibril assembly (GO:0030239)4.14193041
30striated muscle atrophy (GO:0014891)4.10419084
31muscle tissue morphogenesis (GO:0060415)3.98947193
32outer ear morphogenesis (GO:0042473)3.98514718
33myoblast fusion (GO:0007520)3.97859358
34negative regulation of potassium ion transmembrane transport (GO:1901380)3.96802156
35muscle cell fate commitment (GO:0042693)3.91125209
36positive regulation of myotube differentiation (GO:0010831)3.89065755
37cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.87782339
38response to muscle activity (GO:0014850)3.83745694
39negative regulation of fatty acid transport (GO:2000192)3.83581709
40striated muscle contraction (GO:0006941)3.82734647
41response to inactivity (GO:0014854)3.82644968
42heart process (GO:0003015)3.81161967
43heart contraction (GO:0060047)3.81161967
44craniofacial suture morphogenesis (GO:0097094)3.78037151
45striated muscle tissue development (GO:0014706)3.74850403
46muscle contraction (GO:0006936)3.72591376
47syncytium formation (GO:0006949)3.71449223
48NADH metabolic process (GO:0006734)3.69603001
49skin morphogenesis (GO:0043589)3.62876047
50cardiac muscle hypertrophy (GO:0003300)3.61334007
51syncytium formation by plasma membrane fusion (GO:0000768)3.59438065
52protein hydroxylation (GO:0018126)3.58906744
53response to activity (GO:0014823)3.55471833
54endodermal cell differentiation (GO:0035987)3.55237928
55polysaccharide catabolic process (GO:0000272)3.52389664
56cardiac muscle tissue morphogenesis (GO:0055008)3.50862890
57muscle organ development (GO:0007517)3.48472631
58actomyosin structure organization (GO:0031032)3.47496897
59striated muscle hypertrophy (GO:0014897)3.47439350
60chondrocyte development (GO:0002063)3.46353218
61regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.43832869
62muscle tissue development (GO:0060537)3.43413753
63muscle atrophy (GO:0014889)3.43078615
64muscle structure development (GO:0061061)3.42516132
65middle ear morphogenesis (GO:0042474)3.42360978
66positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.41341463
67negative regulation of chondrocyte differentiation (GO:0032331)3.40455245
68muscle fiber development (GO:0048747)3.40235439
69regulation of striated muscle contraction (GO:0006942)3.40116451
70cardiac muscle cell development (GO:0055013)3.36637622
71collagen metabolic process (GO:0032963)3.35844699
72regulation of myoblast differentiation (GO:0045661)3.32926472
73metanephric mesenchyme development (GO:0072075)3.31418703
74axon extension involved in axon guidance (GO:0048846)3.31329015
75neuron projection extension involved in neuron projection guidance (GO:1902284)3.31329015
76negative regulation of protein localization to cell surface (GO:2000009)3.30741104
77regulation of sequestering of triglyceride (GO:0010889)3.29775410
78* embryonic cranial skeleton morphogenesis (GO:0048701)3.29657314
79collagen catabolic process (GO:0030574)3.29106091
80regulation of actin filament-based movement (GO:1903115)3.26922188
81regulation of cell communication by electrical coupling (GO:0010649)3.26805588
82muscle adaptation (GO:0043500)3.26278715
83glycogen catabolic process (GO:0005980)3.26196761
84striated muscle adaptation (GO:0014888)3.26070622
85muscle system process (GO:0003012)3.25821507
86glycogen metabolic process (GO:0005977)3.23821192
87muscle hypertrophy (GO:0014896)3.23386365
88regulation of the force of heart contraction (GO:0002026)3.23356892
89embryonic skeletal joint morphogenesis (GO:0060272)3.22432730
90cranial suture morphogenesis (GO:0060363)3.22094573
91positive regulation of myoblast differentiation (GO:0045663)3.21406472
92planar cell polarity pathway involved in neural tube closure (GO:0090179)3.19304943
93regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.18820319
94peptidyl-proline hydroxylation (GO:0019511)3.18638450
95glucan metabolic process (GO:0044042)3.15484809
96cellular glucan metabolic process (GO:0006073)3.15484809
97regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.14570356
98hippo signaling (GO:0035329)3.12833483
99myotube differentiation (GO:0014902)3.11792805
100muscle cell development (GO:0055001)3.10876681
101multicellular organismal macromolecule metabolic process (GO:0044259)3.10424391
102regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.09606016
103cardiac cell development (GO:0055006)3.09492029
104paraxial mesoderm development (GO:0048339)3.08906326
105kidney mesenchyme development (GO:0072074)3.08119791
106purine nucleotide salvage (GO:0032261)3.06142171
107negative regulation of skeletal muscle tissue development (GO:0048642)3.05097982
108regulation of skeletal muscle cell differentiation (GO:2001014)3.04907158
109regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.04547124
110carnitine shuttle (GO:0006853)3.04543947
111positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.00518248
112glucan catabolic process (GO:0009251)2.99991326
113creatine metabolic process (GO:0006600)2.97463344
114multicellular organismal catabolic process (GO:0044243)2.96984001
115regulation of muscle system process (GO:0090257)2.96413871
116dermatan sulfate biosynthetic process (GO:0030208)2.94882593
117cardiac myofibril assembly (GO:0055003)2.93676281
1182-oxoglutarate metabolic process (GO:0006103)2.92751558
119gluconeogenesis (GO:0006094)2.91988766
120cell migration involved in heart development (GO:0060973)2.90313855
121multicellular organismal metabolic process (GO:0044236)2.90205293
122regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.88404730
123fructose metabolic process (GO:0006000)2.88332183
124skeletal muscle tissue development (GO:0007519)2.88315477
125regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.87387604
126regulation of skeletal muscle fiber development (GO:0048742)2.87082470
127regulation of sarcomere organization (GO:0060297)2.85499099
128organ induction (GO:0001759)2.83591873
129negative regulation of cartilage development (GO:0061037)2.83400429
130adult heart development (GO:0007512)2.82308371
131positive regulation of mesenchymal cell proliferation (GO:0002053)2.81642353
132regulation of chondrocyte differentiation (GO:0032330)2.81343554
133regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.79081624
134regulation of cartilage development (GO:0061035)2.78577439
135positive regulation of skeletal muscle tissue development (GO:0048643)2.77794235
136negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.77692272
137muscle cell cellular homeostasis (GO:0046716)2.77181563
138extracellular regulation of signal transduction (GO:1900115)2.76744125
139extracellular negative regulation of signal transduction (GO:1900116)2.76744125
140keratan sulfate catabolic process (GO:0042340)2.74781773
141IMP metabolic process (GO:0046040)2.74211469
142peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.74192590
143regulation of calcium ion transmembrane transporter activity (GO:1901019)2.73640452
144regulation of calcium ion transmembrane transport (GO:1903169)2.73640452
145striated muscle cell development (GO:0055002)2.73499156
146regulation of myotube differentiation (GO:0010830)2.73299669
147prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.73024400
148cellular polysaccharide catabolic process (GO:0044247)2.72240929
149positive regulation of cartilage development (GO:0061036)2.71925814
150regulation of heart morphogenesis (GO:2000826)2.70496758
151dermatan sulfate metabolic process (GO:0030205)2.68015218

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.17842227
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.55630881
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.31827260
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.40972460
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.09518993
6RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.90846322
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.90826281
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.66782079
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.52364844
10* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.49959378
11CJUN_26792858_Chip-Seq_BT549_Human2.48437856
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45447461
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.39844488
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.35370984
15ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.21274763
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.18511096
17CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.17315197
18CLOCK_20551151_ChIP-Seq_293T_Human2.15640084
19* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.14363754
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.14030128
21* TP53_20018659_ChIP-ChIP_R1E_Mouse2.12824347
22* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.12314281
23* BRD4_25478319_ChIP-Seq_HGPS_Human2.09827782
24ESR1_20079471_ChIP-ChIP_T-47D_Human2.09408101
25EP300_21415370_ChIP-Seq_HL-1_Mouse2.06832048
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03287008
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.99490006
28NRF2_20460467_ChIP-Seq_MEFs_Mouse1.99490006
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95885102
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94226692
31MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.94126949
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93397517
33* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.86061080
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.84064809
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83295392
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82944210
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.81480088
38TBX20_22080862_ChIP-Seq_HEART_Mouse1.81480088
39* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73339072
40TP53_18474530_ChIP-ChIP_U2OS_Human1.73212174
41GBX2_23144817_ChIP-Seq_PC3_Human1.73097192
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72630017
43* EED_16625203_ChIP-ChIP_MESCs_Mouse1.67413850
44PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.65797010
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65214887
46EZH2_22144423_ChIP-Seq_EOC_Human1.64761930
47* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62795698
48* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62795698
49AR_21572438_ChIP-Seq_LNCaP_Human1.58286779
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57186338
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46923101
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.45864005
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45446725
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41393191
55* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40697969
56* EZH2_27304074_Chip-Seq_ESCs_Mouse1.38514659
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.35156446
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35119859
59NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.34906996
60* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.34765473
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34152519
62SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34152519
63ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.33327646
64SA1_22415368_ChIP-Seq_MEFs_Mouse1.33074344
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.32854693
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.32649053
67LXR_22158963_ChIP-Seq_LIVER_Mouse1.31758432
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.31146473
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30151661
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28311616
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28155012
72* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28140517
73RXR_22108803_ChIP-Seq_LS180_Human1.27980966
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.27660682
75JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26974791
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26203172
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.24674419
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24011148
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23272863
80* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23139098
81TP53_23651856_ChIP-Seq_MEFs_Mouse1.23132982
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23059456
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22881267
84ZNF274_21170338_ChIP-Seq_K562_Hela1.22118206
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20649573
86* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20551000
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.20284164
88* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19547557
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17145116
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.16786792
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16260094
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15957528
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15548041
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15139085
95ISL1_27105846_Chip-Seq_CPCs_Mouse1.14558809
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14546515
97* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14425643
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.12987711
99TP53_22127205_ChIP-Seq_IMR90_Human1.12414648
100* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11671154
101PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11579991
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11504238
103* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09529266
104P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09430107
105TP53_16413492_ChIP-PET_HCT116_Human1.08904373
106OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08899896
107ATF3_27146783_Chip-Seq_COLON_Human1.08877462
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08077816
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07487576
110EGR1_19374776_ChIP-ChIP_THP-1_Human1.06526969
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05787157
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03538083
113* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02402006
114* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02354385
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01991931
116GATA2_21666600_ChIP-Seq_HMVEC_Human1.01472862
117EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00966326
118* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98078617
119PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95770458
120GATA4_21415370_ChIP-Seq_HL-1_Mouse0.95447298
121RACK7_27058665_Chip-Seq_MCF-7_Human0.95081166
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94828406
123ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94689151
124TCF4_18268006_ChIP-ChIP_LS174T_Human0.94123592
125SALL1_21062744_ChIP-ChIP_HESCs_Human0.93203645
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92975316
127NANOG_16153702_ChIP-ChIP_HESCs_Human0.92860383
128STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.92146918
129* NFI_21473784_ChIP-Seq_ESCs_Mouse0.91185002
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90489785
131PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.90089029
132ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89234186
133* RNF2_27304074_Chip-Seq_ESCs_Mouse0.88318219
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87569419
135CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87533596
136MYC_27129775_Chip-Seq_CORNEA_Mouse0.83706355
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83129323
138SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.82727030
139* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81596989
140* SMAD4_21799915_ChIP-Seq_A2780_Human0.80600265
141KDM2B_26808549_Chip-Seq_REH_Human0.80474706
142FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79883481
143ZNF263_19887448_ChIP-Seq_K562_Human0.78616200
144* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.78449203
145NFE2_27457419_Chip-Seq_LIVER_Mouse0.78421340
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78346363
147* CBX2_27304074_Chip-Seq_ESCs_Mouse0.78019091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.54237384
2MP0004145_abnormal_muscle_electrophysio4.77334051
3MP0005503_abnormal_tendon_morphology4.64364475
4MP0005275_abnormal_skin_tensile4.07731966
5MP0000749_muscle_degeneration3.99550244
6MP0000751_myopathy3.95493549
7MP0003705_abnormal_hypodermis_morpholog3.17091540
8MP0000733_abnormal_muscle_development2.99190756
9MP0000750_abnormal_muscle_regeneration2.88319680
10MP0000747_muscle_weakness2.87314984
11MP0003646_muscle_fatigue2.78819778
12MP0002108_abnormal_muscle_morphology2.73131476
13* MP0000759_abnormal_skeletal_muscle2.72975026
14MP0002106_abnormal_muscle_physiology2.68545593
15MP0005369_muscle_phenotype2.54971185
16MP0004233_abnormal_muscle_weight2.41024978
17MP0004087_abnormal_muscle_fiber2.32308060
18MP0003279_aneurysm2.16881768
19* MP0009250_abnormal_appendicular_skeleto2.13772467
20MP0002269_muscular_atrophy2.06212882
21MP0010030_abnormal_orbit_morphology2.01940120
22MP0005257_abnormal_intraocular_pressure1.99918724
23MP0004134_abnormal_chest_morphology1.97505298
24MP0004036_abnormal_muscle_relaxation1.97335566
25MP0009780_abnormal_chondrocyte_physiolo1.96035731
26MP0005451_abnormal_body_composition1.89374338
27MP0003385_abnormal_body_wall1.79449488
28MP0005620_abnormal_muscle_contractility1.78820221
29MP0004272_abnormal_basement_membrane1.73347337
30MP0002837_dystrophic_cardiac_calcinosis1.73156110
31MP0005623_abnormal_meninges_morphology1.67959582
32MP0001958_emphysema1.65133311
33* MP0005508_abnormal_skeleton_morphology1.61977574
34MP0009053_abnormal_anal_canal1.59811332
35MP0009384_cardiac_valve_regurgitation1.54259576
36* MP0001299_abnormal_eye_distance/1.50096520
37MP0002896_abnormal_bone_mineralization1.48727621
38MP0000762_abnormal_tongue_morphology1.41500976
39MP0001243_abnormal_dermal_layer1.39846885
40MP0004130_abnormal_muscle_cell1.39542055
41MP0001661_extended_life_span1.39132141
42MP0010352_gastrointestinal_tract_polyps1.34896371
43MP0004215_abnormal_myocardial_fiber1.34048954
44MP0002060_abnormal_skin_morphology1.33717925
45MP0003755_abnormal_palate_morphology1.32319525
46MP0002932_abnormal_joint_morphology1.31119127
47MP0004270_analgesia1.25522591
48MP0004510_myositis1.24775428
49MP0003941_abnormal_skin_development1.23063911
50* MP0002115_abnormal_skeleton_extremities1.22656179
51MP0006054_spinal_hemorrhage1.17726870
52MP0006138_congestive_heart_failure1.14140175
53MP0005023_abnormal_wound_healing1.13206347
54* MP0000163_abnormal_cartilage_morphology1.11334506
55MP0003950_abnormal_plasma_membrane1.10256251
56MP0001544_abnormal_cardiovascular_syste1.10106009
57MP0005385_cardiovascular_system_phenoty1.10106009
58MP0002282_abnormal_trachea_morphology1.09387916
59MP0002127_abnormal_cardiovascular_syste1.09135942
60MP0006036_abnormal_mitochondrial_physio1.08340337
61MP0003942_abnormal_urinary_system1.07814887
62MP0005076_abnormal_cell_differentiation1.06907796
63MP0000013_abnormal_adipose_tissue1.04784412
64MP0003828_pulmonary_edema1.03415128
65* MP0002109_abnormal_limb_morphology1.03149998
66MP0004185_abnormal_adipocyte_glucose1.02469460
67MP0003566_abnormal_cell_adhesion1.02374450
68MP0000049_abnormal_middle_ear1.01716469
69MP0001542_abnormal_bone_strength1.00009178
70MP0001346_abnormal_lacrimal_gland0.99455278
71MP0005266_abnormal_metabolism0.98970193
72* MP0000428_abnormal_craniofacial_morphol0.97785691
73MP0005330_cardiomyopathy0.97700301
74* MP0002114_abnormal_axial_skeleton0.97261357
75MP0002249_abnormal_larynx_morphology0.96814452
76MP0003091_abnormal_cell_migration0.95142342
77MP0004084_abnormal_cardiac_muscle0.94790580
78MP0008775_abnormal_heart_ventricle0.94441889
79MP0005670_abnormal_white_adipose0.93034858
80* MP0002113_abnormal_skeleton_development0.92418691
81MP0000767_abnormal_smooth_muscle0.91597461
82MP0000003_abnormal_adipose_tissue0.90481313
83MP0002332_abnormal_exercise_endurance0.87213425
84MP0010630_abnormal_cardiac_muscle0.86067695
85MP0002089_abnormal_postnatal_growth/wei0.86034187
86* MP0003937_abnormal_limbs/digits/tail_de0.85893290
87MP0002971_abnormal_brown_adipose0.85140601
88MP0001348_abnormal_lacrimal_gland0.85020236
89* MP0002116_abnormal_craniofacial_bone0.83732723
90MP0002877_abnormal_melanocyte_morpholog0.82841373
91MP0010368_abnormal_lymphatic_system0.82785762
92MP0005375_adipose_tissue_phenotype0.82080068
93MP0000534_abnormal_ureter_morphology0.80501374
94* MP0005390_skeleton_phenotype0.79317307
95MP0000537_abnormal_urethra_morphology0.78862465
96MP0003045_fibrosis0.76683883
97* MP0000432_abnormal_head_morphology0.76036193
98MP0005187_abnormal_penis_morphology0.74616358
99MP0002933_joint_inflammation0.74131276
100MP0002234_abnormal_pharynx_morphology0.74009539
101MP0003935_abnormal_craniofacial_develop0.72769154
102MP0000516_abnormal_urinary_system0.72246007
103MP0005367_renal/urinary_system_phenotyp0.72246007
104MP0005666_abnormal_adipose_tissue0.71208757
105MP0002295_abnormal_pulmonary_circulatio0.69701991
106MP0004484_altered_response_of0.69218544
107MP0002972_abnormal_cardiac_muscle0.68792487
108MP0003221_abnormal_cardiomyocyte_apopto0.68038425
109MP0004197_abnormal_fetal_growth/weight/0.67902902
110MP0002168_other_aberrant_phenotype0.67802405
111MP0001849_ear_inflammation0.67030240
112MP0003959_abnormal_lean_body0.65986990
113MP0003137_abnormal_impulse_conducting0.65557514
114MP0000579_abnormal_nail_morphology0.65351776
115MP0002233_abnormal_nose_morphology0.65103009
116MP0003283_abnormal_digestive_organ0.62255707
117MP0002111_abnormal_tail_morphology0.61935711
118MP0005248_abnormal_Harderian_gland0.60341678
119MP0002876_abnormal_thyroid_physiology0.60086773
120MP0003115_abnormal_respiratory_system0.58744652
121MP0002128_abnormal_blood_circulation0.57911341
122MP0001879_abnormal_lymphatic_vessel0.56322651
123MP0000266_abnormal_heart_morphology0.56276145
124MP0005595_abnormal_vascular_smooth0.56173805
125MP0003011_delayed_dark_adaptation0.45859684
126MP0005360_urolithiasis0.45322915
127MP0005165_increased_susceptibility_to0.45126944
128MP0003879_abnormal_hair_cell0.44753698
129MP0004085_abnormal_heartbeat0.44579264
130MP0003191_abnormal_cellular_cholesterol0.43148814
131MP0000230_abnormal_systemic_arterial0.39671885
132MP0005171_absent_coat_pigmentation0.38812691
133MP0005083_abnormal_biliary_tract0.38566971
134MP0005452_abnormal_adipose_tissue0.36933873
135MP0004858_abnormal_nervous_system0.35544684

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.56562398
2Type 1 muscle fiber predominance (HP:0003803)7.52587790
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.40815005
4Nemaline bodies (HP:0003798)6.82692781
5Distal arthrogryposis (HP:0005684)6.27574580
6Round ear (HP:0100830)5.95601581
7Exercise-induced myalgia (HP:0003738)5.40695184
8Calcaneovalgus deformity (HP:0001848)5.18256714
9Exercise-induced muscle cramps (HP:0003710)5.14014085
10Ulnar deviation of the wrist (HP:0003049)5.12081875
11Deformed tarsal bones (HP:0008119)4.87843613
12Myopathic facies (HP:0002058)4.87362820
13Protrusio acetabuli (HP:0003179)4.84270309
14Premature rupture of membranes (HP:0001788)4.62104518
15Increased connective tissue (HP:0009025)4.47307319
16Muscle hypertrophy of the lower extremities (HP:0008968)4.46645953
17Muscle fiber splitting (HP:0003555)4.20623118
18Calf muscle hypertrophy (HP:0008981)4.05213289
19* Absent phalangeal crease (HP:0006109)4.03567663
20Difficulty running (HP:0009046)3.95001701
21Abnormality of skeletal muscle fiber size (HP:0012084)3.82949835
22Slender build (HP:0001533)3.71030578
23Centrally nucleated skeletal muscle fibers (HP:0003687)3.68841642
24Increased variability in muscle fiber diameter (HP:0003557)3.64677760
25Popliteal pterygium (HP:0009756)3.61464255
26Abnormality of the calcaneus (HP:0008364)3.59759232
27Hyporeflexia of lower limbs (HP:0002600)3.48584497
28Type 2 muscle fiber atrophy (HP:0003554)3.44156032
29Weak cry (HP:0001612)3.39203058
30Abnormality of the calf musculature (HP:0001430)3.38134005
31Spinal rigidity (HP:0003306)3.35977584
32EMG: myopathic abnormalities (HP:0003458)3.32119010
33* Abnormal finger flexion creases (HP:0006143)3.23512804
34Malignant hyperthermia (HP:0002047)3.23334347
35Shallow orbits (HP:0000586)3.23016602
36Difficulty climbing stairs (HP:0003551)3.19251815
37Mildly elevated creatine phosphokinase (HP:0008180)3.18467336
38Muscle fiber atrophy (HP:0100295)3.04939062
39Broad metatarsal (HP:0001783)2.93547436
40Myotonia (HP:0002486)2.89977777
41Muscle stiffness (HP:0003552)2.87828677
42Myoglobinuria (HP:0002913)2.82004955
43Ankle contracture (HP:0006466)2.78851077
44Asymmetric septal hypertrophy (HP:0001670)2.76417248
45Aortic dissection (HP:0002647)2.74588630
46Sudden death (HP:0001699)2.72517665
47Pelvic girdle muscle weakness (HP:0003749)2.69502249
48Atrophic scars (HP:0001075)2.65554234
49Peritonitis (HP:0002586)2.62292112
50Shoulder girdle muscle weakness (HP:0003547)2.60160935
51Hip contracture (HP:0003273)2.59614228
52Abnormality of the musculature of the pelvis (HP:0001469)2.57181762
53Abnormality of the hip-girdle musculature (HP:0001445)2.57181762
54Abnormality of placental membranes (HP:0011409)2.54511959
55Amniotic constriction ring (HP:0009775)2.54511959
56Soft skin (HP:0000977)2.53201422
57Breech presentation (HP:0001623)2.52269741
58Neck muscle weakness (HP:0000467)2.49972010
59Scapular winging (HP:0003691)2.46670696
60Lipoatrophy (HP:0100578)2.44393429
61Limb-girdle muscle weakness (HP:0003325)2.44385082
62Tarsal synostosis (HP:0008368)2.42174875
63Aplasia of the musculature (HP:0100854)2.41915332
64Neonatal short-limb short stature (HP:0008921)2.38601473
65Increased density of long bones (HP:0006392)2.38577476
66EMG: neuropathic changes (HP:0003445)2.38408444
67Nonprogressive disorder (HP:0003680)2.37521010
68Follicular hyperkeratosis (HP:0007502)2.36995071
69Fragile skin (HP:0001030)2.33715401
70Frequent falls (HP:0002359)2.33383691
71Rhabdomyolysis (HP:0003201)2.32179080
72Abnormality of the left ventricular outflow tract (HP:0011103)2.31043728
73Subaortic stenosis (HP:0001682)2.31043728
74Respiratory insufficiency due to muscle weakness (HP:0002747)2.26835299
75Distal lower limb amyotrophy (HP:0008944)2.25869182
76Metatarsus adductus (HP:0001840)2.25738636
77Ulnar deviation of finger (HP:0009465)2.25518867
78Bundle branch block (HP:0011710)2.24727765
79Fatigable weakness (HP:0003473)2.21063023
80Abnormality of the neuromuscular junction (HP:0003398)2.21063023
81Dilated cardiomyopathy (HP:0001644)2.19722657
82Easy fatigability (HP:0003388)2.18346132
83Synostosis involving bones of the lower limbs (HP:0009138)2.15256569
84Synostosis involving bones of the feet (HP:0009140)2.15256569
85Cervical subluxation (HP:0003308)2.12406446
86Genu recurvatum (HP:0002816)2.09455501
87Rimmed vacuoles (HP:0003805)2.08093139
88Abnormality of dentin (HP:0010299)2.03874969
89Hyperkalemia (HP:0002153)2.03004730
90Abnormality of the shoulder girdle musculature (HP:0001435)2.02367336
91Dilatation of the ascending aorta (HP:0005111)2.01543798
92Mitral valve prolapse (HP:0001634)2.00374122
93Limited hip movement (HP:0008800)2.00121605
94Bladder diverticulum (HP:0000015)1.96255648
95Cerebral aneurysm (HP:0004944)1.94255494
96Abnormal delivery (HP:0001787)1.93920421
97Distal lower limb muscle weakness (HP:0009053)1.93543062
98Aortic aneurysm (HP:0004942)1.93173284
99Areflexia of lower limbs (HP:0002522)1.92958874
100Waddling gait (HP:0002515)1.91769728
101Ventricular tachycardia (HP:0004756)1.91277259
102Muscular dystrophy (HP:0003560)1.88502023
103Fetal akinesia sequence (HP:0001989)1.86251583
104Infantile muscular hypotonia (HP:0008947)1.84422311
105Blue sclerae (HP:0000592)1.84087378
106Delayed gross motor development (HP:0002194)1.83066854
107* Hypoplastic ischia (HP:0003175)1.82947892
108Elbow flexion contracture (HP:0002987)1.82820732
109Knee flexion contracture (HP:0006380)1.81140685
110Generalized muscle weakness (HP:0003324)1.79209154
111* Abnormality of the ischium (HP:0003174)1.79023903
112Achilles tendon contracture (HP:0001771)1.77794624
113Gowers sign (HP:0003391)1.75038413
114Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.72859003
115Congenital hip dislocation (HP:0001374)1.71990782
116Lower limb amyotrophy (HP:0007210)1.69558073
117Short 4th metacarpal (HP:0010044)1.69312605
118Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69312605
119Limb-girdle muscle atrophy (HP:0003797)1.69145695
120Bulbar palsy (HP:0001283)1.69144822
121Proximal amyotrophy (HP:0007126)1.67865882
122Thin ribs (HP:0000883)1.65863190
123Pterygium (HP:0001059)1.63455708
124Reduced subcutaneous adipose tissue (HP:0003758)1.60667890
125Abnormality of the foot musculature (HP:0001436)1.52635631
126Hypoalphalipoproteinemia (HP:0003233)1.49203300
127Generalized amyotrophy (HP:0003700)1.48848250
128Foot dorsiflexor weakness (HP:0009027)1.47453270
129Vascular tortuosity (HP:0004948)1.46245845
130Heart block (HP:0012722)1.43798950
131Progressive muscle weakness (HP:0003323)1.42615206
132Oligomenorrhea (HP:0000876)1.41085296
133Abnormal atrioventricular conduction (HP:0005150)1.40745178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.56539624
2OBSCN6.35442804
3DDR24.19330260
4PIK3CG3.68658049
5PHKG13.55908545
6PHKG23.55908545
7TRIB33.34841276
8NME12.76639319
9LATS12.43433402
10PDGFRA2.24614305
11MAP2K32.11580049
12LATS22.09356719
13SIK12.05856955
14PIK3CA1.87308240
15NEK11.77421834
16DMPK1.70932099
17MOS1.49329968
18MAP3K71.47250134
19PKN21.43599192
20NEK91.38946962
21MYLK1.32017978
22TRPM71.25033046
23EPHB21.23911589
24ERBB31.23118700
25FER1.21294288
26FGFR11.20307305
27PDK41.18869810
28PDK31.18869810
29BMX1.18513207
30CCNB11.09833129
31MAP3K121.06195071
32MAPK121.04276307
33EPHA31.03968084
34STK31.03375732
35PAK21.02200346
36MUSK1.00591397
37MAP3K30.95645214
38RIPK10.95413891
39ZAK0.90311627
40TAOK20.86712193
41PTK60.83242889
42LIMK10.79874510
43PTK20.76713784
44PDK20.74936214
45FGFR20.73616534
46ILK0.72692989
47ROCK10.71785010
48MTOR0.69163854
49PAK30.68667289
50MAP2K10.65829027
51PIM20.64875116
52TIE10.63614215
53MARK10.62943379
54PKN10.62602845
55MAP2K40.62153780
56ERN10.60060479
57MAP3K100.57194508
58LRRK20.56470395
59TGFBR20.54879355
60PRKAA20.54873300
61CAMK2D0.54605518
62AKT20.54060967
63STK38L0.54046527
64PAK40.53501490
65PDGFRB0.53075017
66EPHB10.52151378
67EEF2K0.52112728
68PTK2B0.50761911
69RPS6KA40.47684886
70EIF2AK30.46634542
71PINK10.44757108
72MET0.44051860
73MELK0.42676577
74TBK10.42169744
75MAPK40.41691363
76CDK60.41044664
77CDK120.39613342
78BCKDK0.39507481
79STK240.38245675
80TAOK10.37926155
81PRKAA10.37453246
82SGK30.37253881
83ROCK20.36725988
84MAP2K60.35867495
85CAMK2B0.35548634
86DYRK1B0.34219661
87CAMK10.32591765
88DAPK30.32370099
89NLK0.32369753
90AKT30.31578467
91CAMK40.30210097
92CAMK2A0.30007833
93CDK80.28732055
94SGK20.28662600
95PLK20.28395978
96ABL20.28357190
97PRKD10.28298880
98MAPK110.27753281
99NME20.26331242
100RPS6KB20.26133599
101MAPK70.26086688
102TYK20.25332502
103MAP3K130.24732291
104WNK10.23017859
105INSR0.22834561
106MAPKAPK50.22729238
107MAP3K50.22460677
108CAMK1G0.22447311
109FGFR30.22062522
110FRK0.22051689
111ADRBK10.22014474
112CDC42BPA0.21412690
113PRKACA0.19889851
114MAP3K80.19353927
115ICK0.19302292
116PRKD20.17907570
117MAPKAPK30.17714630
118JAK10.17244307
119RPS6KA30.16964035
120CAMK2G0.16280639
121MAPK130.16232543
122GRK70.16004719
123CAMK1D0.15990080
124GSK3A0.15699400
125PRKG10.14964690
126RPS6KB10.13861931
127PAK60.13497821
128RET0.12750953
129MAPK10.12589029
130MARK20.12292173
131MAPK80.12242757
132KSR10.11918039
133MAPK100.11321814
134PRKACB0.11247406
135PDPK10.10771761
136MAP3K60.10412463
137SGK10.09991588

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.09935708
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.90524903
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.58968832
4ECM-receptor interaction_Homo sapiens_hsa045123.53010188
5Dilated cardiomyopathy_Homo sapiens_hsa054143.45897721
6Focal adhesion_Homo sapiens_hsa045103.04132401
7Basal cell carcinoma_Homo sapiens_hsa052172.25508251
8Proteoglycans in cancer_Homo sapiens_hsa052052.25414762
9Protein digestion and absorption_Homo sapiens_hsa049742.08228233
10Adherens junction_Homo sapiens_hsa045202.07995689
11Arginine biosynthesis_Homo sapiens_hsa002202.00385626
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.88259995
13Hedgehog signaling pathway_Homo sapiens_hsa043401.81269751
14Fatty acid degradation_Homo sapiens_hsa000711.73962587
15Tight junction_Homo sapiens_hsa045301.73218099
16Propanoate metabolism_Homo sapiens_hsa006401.73164375
17Amoebiasis_Homo sapiens_hsa051461.70019236
18TGF-beta signaling pathway_Homo sapiens_hsa043501.68692500
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.68311936
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68277578
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66855278
22Hippo signaling pathway_Homo sapiens_hsa043901.65704803
23Viral myocarditis_Homo sapiens_hsa054161.62437566
24Insulin signaling pathway_Homo sapiens_hsa049101.62052435
25Cardiac muscle contraction_Homo sapiens_hsa042601.61899329
26Starch and sucrose metabolism_Homo sapiens_hsa005001.60425802
27Malaria_Homo sapiens_hsa051441.58290637
28Bladder cancer_Homo sapiens_hsa052191.57392939
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55848170
30Oxytocin signaling pathway_Homo sapiens_hsa049211.54807886
31Pyruvate metabolism_Homo sapiens_hsa006201.52072098
32Pentose phosphate pathway_Homo sapiens_hsa000301.50030225
33Glucagon signaling pathway_Homo sapiens_hsa049221.48745650
34Melanoma_Homo sapiens_hsa052181.46398109
35MicroRNAs in cancer_Homo sapiens_hsa052061.46305846
36Insulin resistance_Homo sapiens_hsa049311.38348063
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38311650
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.35763236
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31791568
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.30568967
41AMPK signaling pathway_Homo sapiens_hsa041521.29600358
42Chronic myeloid leukemia_Homo sapiens_hsa052201.25322567
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.25310954
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22947416
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18238288
46Wnt signaling pathway_Homo sapiens_hsa043101.17494593
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16680864
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16673105
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16632929
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16349898
51Phenylalanine metabolism_Homo sapiens_hsa003601.15711205
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12669428
53Circadian rhythm_Homo sapiens_hsa047101.12350628
54Small cell lung cancer_Homo sapiens_hsa052221.12088458
55FoxO signaling pathway_Homo sapiens_hsa040681.10489981
56Adipocytokine signaling pathway_Homo sapiens_hsa049201.06960979
57mTOR signaling pathway_Homo sapiens_hsa041501.04130986
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.97602756
59HIF-1 signaling pathway_Homo sapiens_hsa040660.96514750
60Glioma_Homo sapiens_hsa052140.96121213
61PPAR signaling pathway_Homo sapiens_hsa033200.95474445
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95332646
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93062274
64Prostate cancer_Homo sapiens_hsa052150.92786641
65GnRH signaling pathway_Homo sapiens_hsa049120.90920872
66MAPK signaling pathway_Homo sapiens_hsa040100.89513018
67Platelet activation_Homo sapiens_hsa046110.88700329
68Pathways in cancer_Homo sapiens_hsa052000.88518892
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87913902
70p53 signaling pathway_Homo sapiens_hsa041150.87721715
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.87357568
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85522930
73Calcium signaling pathway_Homo sapiens_hsa040200.85052390
74HTLV-I infection_Homo sapiens_hsa051660.81853259
75Renal cell carcinoma_Homo sapiens_hsa052110.81167672
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79511015
77Alzheimers disease_Homo sapiens_hsa050100.79484395
78Melanogenesis_Homo sapiens_hsa049160.79392440
79Galactose metabolism_Homo sapiens_hsa000520.74074682
80VEGF signaling pathway_Homo sapiens_hsa043700.73555846
81Fatty acid metabolism_Homo sapiens_hsa012120.72800911
82Tyrosine metabolism_Homo sapiens_hsa003500.72669089
83Pancreatic cancer_Homo sapiens_hsa052120.72043196
84Tryptophan metabolism_Homo sapiens_hsa003800.71400750
85Axon guidance_Homo sapiens_hsa043600.69568449
86Complement and coagulation cascades_Homo sapiens_hsa046100.67307444
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66884064
88Nitrogen metabolism_Homo sapiens_hsa009100.66293732
89Rap1 signaling pathway_Homo sapiens_hsa040150.66240771
90TNF signaling pathway_Homo sapiens_hsa046680.65666292
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64415076
92Arginine and proline metabolism_Homo sapiens_hsa003300.63241060
93beta-Alanine metabolism_Homo sapiens_hsa004100.60890899
94Renin secretion_Homo sapiens_hsa049240.60307625
95Fatty acid elongation_Homo sapiens_hsa000620.60079779
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59434760
97Colorectal cancer_Homo sapiens_hsa052100.55626306
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55499513
99Carbon metabolism_Homo sapiens_hsa012000.55272803
100Viral carcinogenesis_Homo sapiens_hsa052030.54518088
101Toxoplasmosis_Homo sapiens_hsa051450.53965646
102Parkinsons disease_Homo sapiens_hsa050120.53070184
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51122133
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48643742
105Shigellosis_Homo sapiens_hsa051310.47748521
106Butanoate metabolism_Homo sapiens_hsa006500.47282082
107Gap junction_Homo sapiens_hsa045400.46566696
108Histidine metabolism_Homo sapiens_hsa003400.45114187
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45006538
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.44624206
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41895176
112ErbB signaling pathway_Homo sapiens_hsa040120.41361730
113Lysine degradation_Homo sapiens_hsa003100.41136096
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40811724
115Phagosome_Homo sapiens_hsa041450.39467726
116Salmonella infection_Homo sapiens_hsa051320.39016217
117Ras signaling pathway_Homo sapiens_hsa040140.38250968
118Thyroid cancer_Homo sapiens_hsa052160.38051194
119Endometrial cancer_Homo sapiens_hsa052130.37713742
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.36909474
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36888301
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36344460
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36273283
124Hepatitis B_Homo sapiens_hsa051610.35038491
125Non-small cell lung cancer_Homo sapiens_hsa052230.33312249
126Biosynthesis of amino acids_Homo sapiens_hsa012300.32914239
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32895575
128Sulfur relay system_Homo sapiens_hsa041220.32235466
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31250158
130Peroxisome_Homo sapiens_hsa041460.30407781
131Retinol metabolism_Homo sapiens_hsa008300.30394660
132Prolactin signaling pathway_Homo sapiens_hsa049170.29433980
133Acute myeloid leukemia_Homo sapiens_hsa052210.29334929
134Gastric acid secretion_Homo sapiens_hsa049710.28539750
135Caffeine metabolism_Homo sapiens_hsa002320.27620101
136Regulation of autophagy_Homo sapiens_hsa041400.25939058
137Fructose and mannose metabolism_Homo sapiens_hsa000510.25576897
138Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.24200861
139Cell cycle_Homo sapiens_hsa041100.24017526
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.23987253
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23966630
142Salivary secretion_Homo sapiens_hsa049700.21603797
143Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18282856
144Long-term potentiation_Homo sapiens_hsa047200.16496384

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