TBX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)4.96232374
2enteric nervous system development (GO:0048484)4.88005436
3regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.82508053
4polarized epithelial cell differentiation (GO:0030859)4.55891066
5regulation of endothelial cell differentiation (GO:0045601)4.12234181
6respiratory tube development (GO:0030323)4.11382724
7renal filtration (GO:0097205)4.07953709
8establishment of apical/basal cell polarity (GO:0035089)4.07086268
9lung vasculature development (GO:0060426)4.05140317
10positive regulation of transcription regulatory region DNA binding (GO:2000679)3.99888678
11midgut development (GO:0007494)3.99431404
12endocardial cushion development (GO:0003197)3.94206934
13glomerular filtration (GO:0003094)3.93903124
14positive regulation of fatty acid beta-oxidation (GO:0032000)3.82517134
15* mesenchyme morphogenesis (GO:0072132)3.82398100
16bone trabecula formation (GO:0060346)3.77018185
17positive regulation of endothelial cell differentiation (GO:0045603)3.75493077
18chemical homeostasis within a tissue (GO:0048875)3.75466390
19blood vessel maturation (GO:0001955)3.74631532
20regulation of fatty acid beta-oxidation (GO:0031998)3.72585328
21vascular endothelial growth factor signaling pathway (GO:0038084)3.71247534
22adherens junction assembly (GO:0034333)3.65027324
23endothelial tube morphogenesis (GO:0061154)3.47297952
24morphogenesis of an endothelium (GO:0003159)3.47297952
25lymphangiogenesis (GO:0001946)3.46038197
26establishment or maintenance of monopolar cell polarity (GO:0061339)3.45708933
27establishment of monopolar cell polarity (GO:0061162)3.45708933
28focal adhesion assembly (GO:0048041)3.45310393
29cell-substrate adherens junction assembly (GO:0007045)3.45310393
30lymph vessel development (GO:0001945)3.40370356
31embryonic skeletal joint morphogenesis (GO:0060272)3.39962924
32semaphorin-plexin signaling pathway (GO:0071526)3.38175448
33neuron projection extension involved in neuron projection guidance (GO:1902284)3.34861677
34axon extension involved in axon guidance (GO:0048846)3.34861677
35negative regulation of cell size (GO:0045792)3.34204226
36peripheral nervous system neuron development (GO:0048935)3.33237408
37basement membrane organization (GO:0071711)3.32625492
38embryonic foregut morphogenesis (GO:0048617)3.32420283
39endothelial cell morphogenesis (GO:0001886)3.29348468
40hippo signaling (GO:0035329)3.27439079
41mesonephros development (GO:0001823)3.25553026
42collagen fibril organization (GO:0030199)3.22880118
43COPI coating of Golgi vesicle (GO:0048205)3.18824094
44Golgi transport vesicle coating (GO:0048200)3.18824094
45positive regulation of blood vessel endothelial cell migration (GO:0043536)3.18325553
46cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.18011208
47planar cell polarity pathway involved in neural tube closure (GO:0090179)3.17573625
48cell migration involved in sprouting angiogenesis (GO:0002042)3.17289846
49* endocardial cushion morphogenesis (GO:0003203)3.16041536
50negative regulation of fatty acid transport (GO:2000192)3.15817124
51insulin-like growth factor receptor signaling pathway (GO:0048009)3.15520155
52cell migration involved in heart development (GO:0060973)3.11533101
53artery development (GO:0060840)3.09542524
54regulation of mammary gland epithelial cell proliferation (GO:0033599)3.09277233
55maternal placenta development (GO:0001893)3.08432754
56coronary vasculature morphogenesis (GO:0060977)3.08399375
57regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.05070566
58sympathetic nervous system development (GO:0048485)3.04562633
59Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.03511449
60lung lobe morphogenesis (GO:0060463)3.00839852
61regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.00829101
62positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.00194960
63renal system development (GO:0072001)2.98448289
64* outflow tract septum morphogenesis (GO:0003148)2.97832517
65negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.96655263
66metanephric nephron tubule development (GO:0072234)2.96272573
67metanephric tubule development (GO:0072170)2.96272573
68retina vasculature morphogenesis in camera-type eye (GO:0061299)2.96103216
69muscle cell migration (GO:0014812)2.95515541
70metanephric mesenchyme development (GO:0072075)2.95230890
71ear development (GO:0043583)2.93749365
72metanephric nephron epithelium development (GO:0072243)2.93395680
73heart valve morphogenesis (GO:0003179)2.93015061
74regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.92591409
75gonadal mesoderm development (GO:0007506)2.91313449
76stress fiber assembly (GO:0043149)2.90704304
77regulation of vasculogenesis (GO:2001212)2.90603698
78negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.90301906
79establishment of epithelial cell polarity (GO:0090162)2.89551388
80cell proliferation involved in metanephros development (GO:0072203)2.87494420
81regulation of establishment of planar polarity (GO:0090175)2.85843848
82cysteine metabolic process (GO:0006534)2.84750137
83hypotonic response (GO:0006971)2.84576617
84blood vessel remodeling (GO:0001974)2.83944167
85eyelid development in camera-type eye (GO:0061029)2.83397169
86cell proliferation involved in kidney development (GO:0072111)2.83263664
87skin morphogenesis (GO:0043589)2.83185698
88kidney mesenchyme development (GO:0072074)2.82496748
89cochlea morphogenesis (GO:0090103)2.82154261
90endothelial cell differentiation (GO:0045446)2.80347171
91mesenchymal-epithelial cell signaling (GO:0060638)2.78948939
92cell-substrate junction assembly (GO:0007044)2.78672249
93blood vessel endothelial cell migration (GO:0043534)2.78194896
94paraxial mesoderm development (GO:0048339)2.77679391
95metanephric epithelium development (GO:0072207)2.77311218
96regulation of organ formation (GO:0003156)2.75992022
97negative regulation of catenin import into nucleus (GO:0035414)2.75227225
98atrial septum morphogenesis (GO:0060413)2.74552587
99mesoderm formation (GO:0001707)2.74259544
100* regulation of heart morphogenesis (GO:2000826)2.74002880
101vasculature development (GO:0001944)2.73530102
102atrioventricular valve morphogenesis (GO:0003181)2.73460796
103regulation of glucose import in response to insulin stimulus (GO:2001273)2.73190542
104mesodermal cell differentiation (GO:0048333)2.70070674
105vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.69398902
106positive regulation of epithelial to mesenchymal transition (GO:0010718)2.69209229
107nephron tubule development (GO:0072080)2.68059496
108negative regulation of striated muscle cell apoptotic process (GO:0010664)2.67894579
109branching involved in mammary gland duct morphogenesis (GO:0060444)2.67854049
110regulation of axon extension involved in axon guidance (GO:0048841)2.67336242
111negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.67257817
112uterus development (GO:0060065)2.67068180
113regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.65809098
114axis elongation (GO:0003401)2.65668099
115vagina development (GO:0060068)2.65600612
116positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.65357568
117mammary gland epithelial cell differentiation (GO:0060644)2.63510368
118positive regulation of fatty acid oxidation (GO:0046321)2.63171863
119regulation of secondary heart field cardioblast proliferation (GO:0003266)2.62907462
120regulation of cardioblast proliferation (GO:0003264)2.62907462
121cell migration in hindbrain (GO:0021535)2.62810490
122negative regulation of chondrocyte differentiation (GO:0032331)2.62166658
123mesenchymal cell proliferation (GO:0010463)2.61827433
124mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.61536489
125epoxygenase P450 pathway (GO:0019373)2.61496054
126extracellular matrix assembly (GO:0085029)2.61297400
127non-canonical Wnt signaling pathway (GO:0035567)2.61258693
128dorsal/ventral axis specification (GO:0009950)2.61070873
129organ induction (GO:0001759)2.60783710
130establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.60353047
131regulation of cardioblast differentiation (GO:0051890)2.60001271
132toxin metabolic process (GO:0009404)2.59614951
133anterior/posterior axis specification, embryo (GO:0008595)2.59613317
134diterpenoid biosynthetic process (GO:0016102)2.58042588
135positive regulation of hormone biosynthetic process (GO:0046886)2.57947143
136* embryonic eye morphogenesis (GO:0048048)2.57749195
137regulation of hippo signaling (GO:0035330)2.56616930
138female genitalia development (GO:0030540)2.56265739
139protein retention in ER lumen (GO:0006621)2.56254697
140vasculogenesis (GO:0001570)2.55971380
141endocrine hormone secretion (GO:0060986)2.55810047
142negative regulation of axon extension involved in axon guidance (GO:0048843)2.55364788
143positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.55236060
144protein heterotrimerization (GO:0070208)2.55139685
145negative regulation of adherens junction organization (GO:1903392)2.55116766
146negative regulation of focal adhesion assembly (GO:0051895)2.55116766
147negative regulation of cell junction assembly (GO:1901889)2.55116766
148ganglion development (GO:0061548)2.54860204
149tooth mineralization (GO:0034505)2.53776117
150regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.52959433
151proximal/distal pattern formation (GO:0009954)2.50566875
152endothelial cell chemotaxis (GO:0035767)2.50268690
153fibroblast migration (GO:0010761)2.50143678
154mesenchyme development (GO:0060485)2.49811043
155cardiac myofibril assembly (GO:0055003)2.48758209
156sodium ion homeostasis (GO:0055078)2.48669051
157glomerular basement membrane development (GO:0032836)2.48592598
158lung alveolus development (GO:0048286)2.47846606
159tonic smooth muscle contraction (GO:0014820)2.47797532
160dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.47274576
161male genitalia development (GO:0030539)2.46101367
162anatomical structure regression (GO:0060033)2.45640596
163nephron epithelium development (GO:0072009)2.45573422
164negative regulation of cell fate specification (GO:0009996)2.45524749
165multicellular organismal macromolecule metabolic process (GO:0044259)2.44096897
166lung morphogenesis (GO:0060425)2.43245705
167patterning of blood vessels (GO:0001569)2.43012025
168collagen metabolic process (GO:0032963)2.41805230
169G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.40965063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.99051377
2CLOCK_20551151_ChIP-Seq_293T_Human3.31696348
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.07694748
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.97663143
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61246541
6ESR1_15608294_ChIP-ChIP_MCF-7_Human2.50945500
7EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.44373080
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.34567019
9ZNF263_19887448_ChIP-Seq_K562_Human2.21839835
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.21121588
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.18938186
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18904606
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.09706518
14* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.07160033
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.04213687
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.00105290
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.97061445
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92796785
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92648594
20* ELK3_25401928_ChIP-Seq_HUVEC_Human1.92107082
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.91668344
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.89923910
23* EED_16625203_ChIP-ChIP_MESCs_Mouse1.84098241
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83681651
25* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76606748
26* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76606748
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75236596
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75004269
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72967816
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72209757
31RACK7_27058665_Chip-Seq_MCF-7_Human1.70899222
32* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69744722
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61456149
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.59643132
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.59643132
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59194179
37* ISL1_27105846_Chip-Seq_CPCs_Mouse1.57942296
38KDM2B_26808549_Chip-Seq_K562_Human1.56560444
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.55887474
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55660742
41* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53359501
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52887161
43LXR_22292898_ChIP-Seq_THP-1_Human1.52396026
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50421789
45DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47567999
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45729564
47* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45493999
48CDX2_20551321_ChIP-Seq_CACO-2_Human1.45287668
49* TET1_21451524_ChIP-Seq_MESCs_Mouse1.43118209
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43014131
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42597152
52* TP53_20018659_ChIP-ChIP_R1E_Mouse1.42182386
53TCF7_22412390_ChIP-Seq_EML_Mouse1.42114966
54* TP53_22127205_ChIP-Seq_IMR90_Human1.41655192
55* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41329208
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.41107303
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.39551915
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.39091947
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37476779
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31307595
61SMC3_22415368_ChIP-Seq_MEFs_Mouse1.31294720
62* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30692836
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30489788
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30335334
65SMC1_22415368_ChIP-Seq_MEFs_Mouse1.29836291
66KDM2B_26808549_Chip-Seq_DND41_Human1.29292218
67* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29224672
68* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28889396
69* EZH2_27304074_Chip-Seq_ESCs_Mouse1.28487765
70* ERG_21242973_ChIP-ChIP_JURKAT_Human1.27334941
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27315630
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26818497
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25949974
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25888257
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25883911
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25182365
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24884359
78* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24667711
79RXR_22158963_ChIP-Seq_LIVER_Mouse1.24611540
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.23250212
81* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.23225886
82* RING1B_27294783_Chip-Seq_NPCs_Mouse1.22860608
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22367416
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22366784
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.21720035
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21240186
87* RUNX1_27514584_Chip-Seq_MCF-7_Human1.21161596
88AHR_22903824_ChIP-Seq_MCF-7_Human1.20854752
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20663693
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20663693
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20663693
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20345410
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20245821
94* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19359418
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19148559
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18955484
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18354299
98* RING1B_27294783_Chip-Seq_ESCs_Mouse1.17033905
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16073895
100CREB1_26743006_Chip-Seq_LNCaP_Human1.15637041
101VDR_21846776_ChIP-Seq_THP-1_Human1.15142330
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15055853
103* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14625852
104PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13710860
105SA1_27219007_Chip-Seq_ERYTHROID_Human1.13536727
106ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13463981
107SOX2_20726797_ChIP-Seq_SW620_Human1.13359094
108* RNF2_27304074_Chip-Seq_ESCs_Mouse1.13323696
109SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12441551
110SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12140274
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12006458
112CJUN_26792858_Chip-Seq_BT549_Human1.11654462
113TP53_23651856_ChIP-Seq_MEFs_Mouse1.11550176
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.11130404
115CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11110312
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10739800
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09903509
118SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09169568
119UBF1/2_26484160_Chip-Seq_HMECs_Human1.08888711
120* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08306528
121* EZH2_27294783_Chip-Seq_ESCs_Mouse1.08018733
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06913871
123DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06628102
124EGR1_19374776_ChIP-ChIP_THP-1_Human1.06049199
125MYC_22102868_ChIP-Seq_BL_Human1.04223817
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03615805
127* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02128660
128TET1_21490601_ChIP-Seq_MESCs_Mouse1.01974722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system3.86438530
2MP0001958_emphysema3.81541581
3MP0004272_abnormal_basement_membrane3.67457333
4MP0008438_abnormal_cutaneous_collagen3.21300668
5MP0003705_abnormal_hypodermis_morpholog3.16905999
6MP0001879_abnormal_lymphatic_vessel2.88222530
7MP0000534_abnormal_ureter_morphology2.86204518
8MP0000537_abnormal_urethra_morphology2.75326162
9MP0005367_renal/urinary_system_phenotyp2.41546576
10MP0000516_abnormal_urinary_system2.41546576
11MP0005623_abnormal_meninges_morphology2.20687178
12MP0005377_hearing/vestibular/ear_phenot2.15005612
13MP0003878_abnormal_ear_physiology2.15005612
14MP0009780_abnormal_chondrocyte_physiolo2.06155154
15MP0003385_abnormal_body_wall2.02300869
16MP0009384_cardiac_valve_regurgitation1.90765292
17MP0005275_abnormal_skin_tensile1.90350184
18MP0002138_abnormal_hepatobiliary_system1.90086194
19MP0003942_abnormal_urinary_system1.86039947
20MP0002751_abnormal_autonomic_nervous1.85186718
21MP0000767_abnormal_smooth_muscle1.78354724
22MP0005076_abnormal_cell_differentiation1.77788140
23MP0005503_abnormal_tendon_morphology1.74737311
24MP0009053_abnormal_anal_canal1.73726190
25MP0003279_aneurysm1.70089331
26MP0006138_congestive_heart_failure1.68023567
27MP0005167_abnormal_blood-brain_barrier1.66696100
28MP0005248_abnormal_Harderian_gland1.66147576
29MP0002282_abnormal_trachea_morphology1.63019864
30MP0010030_abnormal_orbit_morphology1.62768545
31MP0004084_abnormal_cardiac_muscle1.62506495
32MP0003566_abnormal_cell_adhesion1.61972209
33MP0001849_ear_inflammation1.61686542
34MP0003115_abnormal_respiratory_system1.60887875
35MP0002877_abnormal_melanocyte_morpholog1.58540239
36MP0009250_abnormal_appendicular_skeleto1.57380399
37MP0001542_abnormal_bone_strength1.51924849
38MP0000538_abnormal_urinary_bladder1.51177591
39MP0000751_myopathy1.47801098
40MP0006054_spinal_hemorrhage1.47501537
41MP0003122_maternal_imprinting1.47411223
42MP0005409_darkened_coat_color1.46498118
43MP0001756_abnormal_urination1.45675424
44MP0002249_abnormal_larynx_morphology1.37190310
45MP0002060_abnormal_skin_morphology1.35543185
46MP0000003_abnormal_adipose_tissue1.33756418
47MP0001299_abnormal_eye_distance/1.30111312
48MP0005408_hypopigmentation1.29866163
49MP0005257_abnormal_intraocular_pressure1.29753809
50MP0001270_distended_abdomen1.29626130
51MP0004782_abnormal_surfactant_physiolog1.22883931
52MP0000013_abnormal_adipose_tissue1.18135651
53MP0000762_abnormal_tongue_morphology1.16850052
54MP0004036_abnormal_muscle_relaxation1.16511600
55MP0010386_abnormal_urinary_bladder1.16267558
56MP0004858_abnormal_nervous_system1.16193893
57MP0002116_abnormal_craniofacial_bone1.14904308
58* MP0003935_abnormal_craniofacial_develop1.14611925
59MP0005197_abnormal_uvea_morphology1.12627406
60MP0000759_abnormal_skeletal_muscle1.09374119
61MP0001664_abnormal_digestion1.09270702
62MP0002009_preneoplasia1.07681115
63MP0005508_abnormal_skeleton_morphology1.07613792
64* MP0002925_abnormal_cardiovascular_devel1.05203678
65MP0002295_abnormal_pulmonary_circulatio1.04789229
66MP0002128_abnormal_blood_circulation1.03489314
67MP0000733_abnormal_muscle_development1.01848034
68MP0005385_cardiovascular_system_phenoty1.01378904
69MP0001544_abnormal_cardiovascular_syste1.01378904
70MP0005360_urolithiasis1.00914882
71MP0005171_absent_coat_pigmentation1.00698814
72MP0002932_abnormal_joint_morphology1.00010409
73MP0003937_abnormal_limbs/digits/tail_de0.99763750
74MP0010234_abnormal_vibrissa_follicle0.99306110
75MP0001243_abnormal_dermal_layer0.99196762
76MP0005058_abnormal_lysosome_morphology0.98966090
77MP0005187_abnormal_penis_morphology0.98206167
78MP0005595_abnormal_vascular_smooth0.97961717
79MP0004381_abnormal_hair_follicle0.97903135
80* MP0001614_abnormal_blood_vessel0.97569235
81MP0000049_abnormal_middle_ear0.96286651
82MP0010630_abnormal_cardiac_muscle0.95161030
83MP0003941_abnormal_skin_development0.94404367
84MP0002089_abnormal_postnatal_growth/wei0.92575166
85MP0002114_abnormal_axial_skeleton0.92352580
86MP0002133_abnormal_respiratory_system0.91027432
87MP0005388_respiratory_system_phenotype0.91027432
88MP0001175_abnormal_lung_morphology0.90910650
89MP0002115_abnormal_skeleton_extremities0.90843311
90MP0000462_abnormal_digestive_system0.90739486
91MP0003567_abnormal_fetal_cardiomyocyte0.89906699
92MP0009643_abnormal_urine_homeostasis0.89320845
93MP0008875_abnormal_xenobiotic_pharmacok0.89168476
94MP0002896_abnormal_bone_mineralization0.88766228
95MP0000163_abnormal_cartilage_morphology0.88490202
96MP0000613_abnormal_salivary_gland0.88386891
97MP0001348_abnormal_lacrimal_gland0.87338138
98MP0003283_abnormal_digestive_organ0.86920015
99MP0000750_abnormal_muscle_regeneration0.86583436
100MP0000428_abnormal_craniofacial_morphol0.86135955
101MP0001765_abnormal_ion_homeostasis0.84367559
102MP0003091_abnormal_cell_migration0.83033710
103MP0003315_abnormal_perineum_morphology0.82202884
104MP0003119_abnormal_digestive_system0.82119452
105MP0005164_abnormal_response_to0.81380227
106MP0005390_skeleton_phenotype0.81363983
107MP0003123_paternal_imprinting0.81168589
108MP0000432_abnormal_head_morphology0.80388129
109MP0002139_abnormal_hepatobiliary_system0.80108747
110MP0002135_abnormal_kidney_morphology0.79799907
111MP0000467_abnormal_esophagus_morphology0.78988247
112MP0002098_abnormal_vibrissa_morphology0.78320808
113MP0000266_abnormal_heart_morphology0.78209299
114MP0003828_pulmonary_edema0.78200946
115MP0002113_abnormal_skeleton_development0.77684928
116MP0005330_cardiomyopathy0.76890391
117MP0004885_abnormal_endolymph0.75829774
118MP0004087_abnormal_muscle_fiber0.75674348
119MP0002653_abnormal_ependyma_morphology0.75609775
120MP0001485_abnormal_pinna_reflex0.75310842
121MP0001661_extended_life_span0.75143935
122MP0005023_abnormal_wound_healing0.75032193
123MP0004085_abnormal_heartbeat0.74928076
124MP0003755_abnormal_palate_morphology0.74018295
125MP0001340_abnormal_eyelid_morphology0.73326938
126MP0005375_adipose_tissue_phenotype0.73057197
127MP0002697_abnormal_eye_size0.73043246
128MP0002972_abnormal_cardiac_muscle0.72313800
129MP0005620_abnormal_muscle_contractility0.72223894
130MP0002136_abnormal_kidney_physiology0.72135568
131MP0002108_abnormal_muscle_morphology0.71685323
132MP0004264_abnormal_extraembryonic_tissu0.71462513
133MP0005193_abnormal_anterior_eye0.70471287
134MP0000470_abnormal_stomach_morphology0.69974812
135MP0004233_abnormal_muscle_weight0.69952946
136* MP0002109_abnormal_limb_morphology0.68625134
137MP0000681_abnormal_thyroid_gland0.67450760
138MP0000579_abnormal_nail_morphology0.66123646
139MP0002177_abnormal_outer_ear0.65704008
140MP0002796_impaired_skin_barrier0.64375864

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)4.80136333
2Aortic dissection (HP:0002647)4.27957046
3Hematochezia (HP:0002573)3.88197906
4Broad metatarsal (HP:0001783)3.82640324
5Hyperactive renin-angiotensin system (HP:0000841)3.63326742
6Ankle contracture (HP:0006466)3.63215743
7Cerebral aneurysm (HP:0004944)3.50164926
8Polycythemia (HP:0001901)3.46627779
9Protrusio acetabuli (HP:0003179)3.38679226
10J-shaped sella turcica (HP:0002680)3.37414317
11Shallow orbits (HP:0000586)3.35266649
12Potter facies (HP:0002009)3.33795546
13Facial shape deformation (HP:0011334)3.33795546
14Cervical subluxation (HP:0003308)3.26573830
15Lymphangioma (HP:0100764)3.16166184
16* Shawl scrotum (HP:0000049)3.05361246
17Bladder diverticulum (HP:0000015)3.00888216
18Hypoventilation (HP:0002791)3.00871456
19Renal duplication (HP:0000075)2.92034435
20Premature rupture of membranes (HP:0001788)2.92028441
21Visceral angiomatosis (HP:0100761)2.89740054
22Abnormality of dentin (HP:0010299)2.83906708
23Aneurysm (HP:0002617)2.82369638
24Partial duplication of the phalanx of hand (HP:0009999)2.79564925
25* Long toe (HP:0010511)2.78798055
26Pulmonary artery stenosis (HP:0004415)2.75514595
27Short 4th metacarpal (HP:0010044)2.73196432
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.73196432
29Biconcave vertebral bodies (HP:0004586)2.72049936
30Vertebral compression fractures (HP:0002953)2.70490790
31Fragile skin (HP:0001030)2.68742549
32Hemangiomatosis (HP:0007461)2.68625055
33* Camptodactyly of toe (HP:0001836)2.65304560
34Follicular hyperkeratosis (HP:0007502)2.61576013
35Mitral valve prolapse (HP:0001634)2.60072346
36* Midline defect of the nose (HP:0004122)2.58777320
37Spinal cord lesions (HP:0100561)2.55763159
38Syringomyelia (HP:0003396)2.55763159
39Congenital glaucoma (HP:0001087)2.55491634
40Blue sclerae (HP:0000592)2.50507465
41Ulnar bowing (HP:0003031)2.47816987
42Genu recurvatum (HP:0002816)2.47319551
43Spontaneous hematomas (HP:0007420)2.46770681
44Hypokalemic alkalosis (HP:0001949)2.46620030
45Abnormality of the phalanges of the hallux (HP:0010057)2.46321669
46Type 1 muscle fiber predominance (HP:0003803)2.46020241
47Deformed sella turcica (HP:0002681)2.44469071
48Turricephaly (HP:0000262)2.44168611
49Interstitial pulmonary disease (HP:0006530)2.44103027
50Thin bony cortex (HP:0002753)2.38285230
51Hyperacusis (HP:0010780)2.38266644
52Abnormality of the umbilical cord (HP:0010881)2.37660185
53Esophageal varix (HP:0002040)2.36544549
54Rectal prolapse (HP:0002035)2.35839881
55Broad face (HP:0000283)2.35776633
56Elfin facies (HP:0004428)2.34162186
57Coronal craniosynostosis (HP:0004440)2.34058140
58Hydroureter (HP:0000072)2.29108114
59Abnormality of the 4th metacarpal (HP:0010012)2.28448184
60Joint laxity (HP:0001388)2.26858081
61Atrophic scars (HP:0001075)2.24397900
62Absent frontal sinuses (HP:0002688)2.22821641
63Abnormal umbilical cord blood vessels (HP:0011403)2.20571413
64Single umbilical artery (HP:0001195)2.20571413
65Abnormality of the fetal cardiovascular system (HP:0010948)2.20571413
66Subacute progressive viral hepatitis (HP:0006572)2.20456203
67Renovascular hypertension (HP:0100817)2.19647113
68Hyperextensible skin (HP:0000974)2.16757633
69Distal lower limb muscle weakness (HP:0009053)2.16512558
70Renal salt wasting (HP:0000127)2.14279899
71Disproportionate tall stature (HP:0001519)2.12404344
72Neonatal short-limb short stature (HP:0008921)2.12223516
73Slender build (HP:0001533)2.12154791
74Bicuspid aortic valve (HP:0001647)2.10526398
75Abnormality of chloride homeostasis (HP:0011422)2.09160988
76Deep venous thrombosis (HP:0002625)2.09107066
77Asymmetry of the thorax (HP:0001555)2.08586477
78Morphological abnormality of the middle ear (HP:0008609)2.08505409
79Knee flexion contracture (HP:0006380)2.08300346
80Malnutrition (HP:0004395)2.06961575
81Obstructive sleep apnea (HP:0002870)2.05982459
82Broad ribs (HP:0000885)2.00866384
83Increased variability in muscle fiber diameter (HP:0003557)2.00358282
84Chorioretinal atrophy (HP:0000533)2.00307867
85Scapular winging (HP:0003691)1.98395652
86Achilles tendon contracture (HP:0001771)1.98154691
87Buphthalmos (HP:0000557)1.97931803
88Cavernous hemangioma (HP:0001048)1.97267043
89Wrist flexion contracture (HP:0001239)1.96472615
90Dilatation of the ascending aorta (HP:0005111)1.94910019
91Distal lower limb amyotrophy (HP:0008944)1.94176240
92Short clavicles (HP:0000894)1.91689075
93Generalized amyotrophy (HP:0003700)1.91628959
94Arterial tortuosity (HP:0005116)1.90327974
95Hypoplastic toenails (HP:0001800)1.90192063
96Deviation of the hallux (HP:0010051)1.90161075
97Vascular tortuosity (HP:0004948)1.89602476
98Mildly elevated creatine phosphokinase (HP:0008180)1.89170143
99Spondylolisthesis (HP:0003302)1.87611501
100Wide anterior fontanel (HP:0000260)1.87449717
101Mitral regurgitation (HP:0001653)1.87435316
102Short hallux (HP:0010109)1.87198841
103Abnormality of the radial head (HP:0003995)1.86646052
104Spinal rigidity (HP:0003306)1.86284285
105Distal upper limb amyotrophy (HP:0007149)1.84893254
106Upper limb amyotrophy (HP:0009129)1.84893254
107Hallux valgus (HP:0001822)1.84359754
108Abnormality of renin-angiotensin system (HP:0000847)1.84344297
109Infantile muscular hypotonia (HP:0008947)1.84339012
110Peritonitis (HP:0002586)1.83765803
111* Joint contractures involving the joints of the feet (HP:0100492)1.82989362
112* Flexion contracture of toe (HP:0005830)1.82989362
113Delayed cranial suture closure (HP:0000270)1.81931676
114Abnormality of the distal phalanx of the thumb (HP:0009617)1.81523682
115Hyperaldosteronism (HP:0000859)1.81170163
116Sprengel anomaly (HP:0000912)1.81133178
117Hypercalciuria (HP:0002150)1.80817142
118Increased connective tissue (HP:0009025)1.80725698
119Stridor (HP:0010307)1.80709716
120Aplasia of the musculature (HP:0100854)1.79147209
121Elbow flexion contracture (HP:0002987)1.78530537
122Flat cornea (HP:0007720)1.78528285
123Hepatoblastoma (HP:0002884)1.78337134
124Partial duplication of thumb phalanx (HP:0009944)1.78261104
125Soft skin (HP:0000977)1.78042668
126Hip contracture (HP:0003273)1.77049111
127Sparse lateral eyebrow (HP:0005338)1.76853284
128Aortic regurgitation (HP:0001659)1.76568615
129Hypoplasia of the iris (HP:0007676)1.76504513
130Abnormality of the parietal bone (HP:0002696)1.75896186
131Round ear (HP:0100830)1.75027657
132Abnormality of the 2nd finger (HP:0004100)1.74576830
133Overriding aorta (HP:0002623)1.73777601
134Protruding ear (HP:0000411)1.72815674
135Premature skin wrinkling (HP:0100678)1.72626120
136Back pain (HP:0003418)1.72603462
137Severe Myopia (HP:0011003)1.72390554
138Venous abnormality (HP:0002624)1.72342377
139Ectopia lentis (HP:0001083)1.71829823
140Hyperparathyroidism (HP:0000843)1.71197731
141Short nail (HP:0001799)1.71047019
142Abnormality of the acetabulum (HP:0003170)1.70355703
143Abnormality of the sella turcica (HP:0002679)1.70184669
144Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.69376107
145Bowel diverticulosis (HP:0005222)1.67419863
146Stroke (HP:0001297)1.66382631
147Arnold-Chiari malformation (HP:0002308)1.66276100
148Gout (HP:0001997)1.65069892
149Chondrocalcinosis (HP:0000934)1.64864081
150Wormian bones (HP:0002645)1.64529743
151Aplasia/Hypoplasia of the hallux (HP:0008362)1.64403691
152Osteolytic defects of the hand bones (HP:0009699)1.64213258
153Osteolytic defects of the phalanges of the hand (HP:0009771)1.64213258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.32312575
2MYLK4.11826490
3TIE13.95672593
4TRIB33.81084772
5TTN3.40357822
6LATS12.96843231
7DDR22.90747415
8EPHB22.89081269
9PDGFRA2.78075936
10PKN22.50487357
11SMG12.43581254
12WNK42.16211577
13TGFBR22.15726444
14ERN12.11277362
15RIPK12.06274631
16PTK62.04120117
17DMPK1.91007886
18LRRK21.71280630
19EPHA31.71234963
20PAK21.70555703
21MAP3K101.64556747
22SCYL21.63547353
23MET1.61689702
24MUSK1.61459119
25MST1R1.57910666
26EEF2K1.56244456
27SIK11.53305381
28EPHA21.48496567
29CDK121.46417468
30TESK11.43816356
31FER1.40111759
32LATS21.38153145
33ILK1.31922755
34IRAK31.30830658
35PAK41.24289359
36STK391.23866804
37TGFBR11.20808655
38BCKDK1.12942025
39STK38L1.12229736
40FLT31.11343592
41EPHB11.08319866
42PTK21.07398066
43FGFR41.04991776
44NME21.03889780
45BMX1.03525985
46LMTK21.01903435
47PDGFRB1.01571217
48KDR0.98619509
49FGFR20.97544582
50CAMK1G0.97023634
51TAOK30.91252424
52TLK10.90422276
53PTK2B0.89961963
54CHUK0.88720673
55ROCK10.85867664
56GRK10.83970548
57PAK30.81812467
58RPS6KA60.80987710
59DAPK30.79761889
60GSK3A0.79646562
61MAP3K20.75435913
62PRKD10.74414376
63GRK70.72632782
64DYRK1B0.71849269
65RET0.70687115
66WNK10.70671822
67CDK70.70525752
68PDK20.69334885
69PRPF4B0.69156578
70MTOR0.68141874
71GRK60.67941322
72CAMK1D0.67342101
73PRKD30.66883377
74ICK0.66020566
75MAP2K10.65950295
76FRK0.65222239
77OXSR10.64059501
78MAP2K20.63923521
79MELK0.63650266
80STK30.62902874
81ERBB20.61358403
82ROCK20.60572668
83MAPKAPK30.59646013
84CDC42BPA0.59609972
85NEK60.59151522
86NTRK10.58694438
87ERBB40.57878254
88LIMK10.56560762
89MAP3K60.56532770
90MAP3K70.56020731
91PHKG20.54522751
92PHKG10.54522751
93CDK80.51807420
94RPS6KA20.49114604
95MAPKAPK20.48410511
96AKT20.47715818
97FGFR10.46938722
98MAP3K30.45769104
99NEK90.44677557
100TRPM70.43483882
101TESK20.42664502
102HIPK20.42605512
103GRK50.42033708
104TAOK20.41203270
105PRKCH0.40704436
106CAMK2G0.40067816
107NUAK10.39650273
108FGFR30.39021767
109KSR20.38618938
110STK380.38417664
111PIK3CG0.37693378
112PIK3CA0.36546155
113CAMK2B0.36501817
114PRKD20.36233215
115WNK30.36058534
116MAPK70.35461583
117MAPK40.35430436
118MAPK110.35139391
119SRC0.35091150
120CAMKK10.34517448
121MARK20.33895324
122PDPK10.32854581
123RPS6KB20.32553617
124PIM20.31742923
125MAP2K30.31522606
126STK100.31517419
127TYRO30.29831316
128ADRBK10.29507299
129RPS6KC10.28865272
130RPS6KL10.28865272
131MOS0.28815979
132MAPK80.28503544
133EGFR0.27334089
134INSR0.26337332
135PDK10.26157371
136MARK30.24971315
137PRKCI0.24325895
138PRKG20.23665902
139JAK20.23562369
140PRKAA20.23265468
141ABL20.22994954
142PAK10.22701168
143FYN0.21890652

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.71313695
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.39015117
3Focal adhesion_Homo sapiens_hsa045102.36080368
4Protein digestion and absorption_Homo sapiens_hsa049742.20112585
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.05702271
6Thyroid cancer_Homo sapiens_hsa052162.02409080
7Hippo signaling pathway_Homo sapiens_hsa043901.92500721
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.87924639
9Basal cell carcinoma_Homo sapiens_hsa052171.85079684
10Adherens junction_Homo sapiens_hsa045201.76431152
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72076571
12Tight junction_Homo sapiens_hsa045301.68433287
13Other glycan degradation_Homo sapiens_hsa005111.64204949
14Proteoglycans in cancer_Homo sapiens_hsa052051.60082303
15Dilated cardiomyopathy_Homo sapiens_hsa054141.58997268
16Hedgehog signaling pathway_Homo sapiens_hsa043401.55351145
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53861735
18Non-small cell lung cancer_Homo sapiens_hsa052231.52841019
19TGF-beta signaling pathway_Homo sapiens_hsa043501.47901727
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.47122411
21Fatty acid degradation_Homo sapiens_hsa000711.45603569
22Bladder cancer_Homo sapiens_hsa052191.42704029
23Notch signaling pathway_Homo sapiens_hsa043301.40813095
24Tryptophan metabolism_Homo sapiens_hsa003801.39199528
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.38439330
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.37479577
27Acute myeloid leukemia_Homo sapiens_hsa052211.36506777
28Small cell lung cancer_Homo sapiens_hsa052221.36198920
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36053638
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36043785
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.32816504
32Nitrogen metabolism_Homo sapiens_hsa009101.30189732
33Bile secretion_Homo sapiens_hsa049761.30009219
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28497383
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25541799
36Melanogenesis_Homo sapiens_hsa049161.23057508
37Axon guidance_Homo sapiens_hsa043601.22373198
38Amoebiasis_Homo sapiens_hsa051461.20210880
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.18416574
40Lysine degradation_Homo sapiens_hsa003101.17076946
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16302072
42ErbB signaling pathway_Homo sapiens_hsa040121.13104299
43Choline metabolism in cancer_Homo sapiens_hsa052311.10210292
44Insulin signaling pathway_Homo sapiens_hsa049101.09272945
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06805104
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06060010
47Renal cell carcinoma_Homo sapiens_hsa052111.05507759
48PPAR signaling pathway_Homo sapiens_hsa033201.04446083
49Insulin resistance_Homo sapiens_hsa049311.03088800
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02577237
51Prolactin signaling pathway_Homo sapiens_hsa049171.02414015
52Propanoate metabolism_Homo sapiens_hsa006401.00790539
53Chronic myeloid leukemia_Homo sapiens_hsa052201.00078262
54Rap1 signaling pathway_Homo sapiens_hsa040150.99327453
55Renin secretion_Homo sapiens_hsa049240.98710536
56Sulfur metabolism_Homo sapiens_hsa009200.97985889
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96381465
58Prion diseases_Homo sapiens_hsa050200.96299249
59PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95119711
60Pathways in cancer_Homo sapiens_hsa052000.94285818
61Sulfur relay system_Homo sapiens_hsa041220.93999760
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92769144
63Pentose phosphate pathway_Homo sapiens_hsa000300.91738508
64MicroRNAs in cancer_Homo sapiens_hsa052060.91312654
65Vibrio cholerae infection_Homo sapiens_hsa051100.90842192
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90631803
67Platelet activation_Homo sapiens_hsa046110.87847115
68Fructose and mannose metabolism_Homo sapiens_hsa000510.87464436
69Colorectal cancer_Homo sapiens_hsa052100.86472145
70Endometrial cancer_Homo sapiens_hsa052130.86294811
71Fatty acid metabolism_Homo sapiens_hsa012120.85577929
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84844417
73Melanoma_Homo sapiens_hsa052180.84706943
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84293717
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.82831929
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82244873
77GnRH signaling pathway_Homo sapiens_hsa049120.79796063
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79764528
79Inositol phosphate metabolism_Homo sapiens_hsa005620.79049003
80Dorso-ventral axis formation_Homo sapiens_hsa043200.78386339
81Thyroid hormone synthesis_Homo sapiens_hsa049180.77692465
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77113881
83Ovarian steroidogenesis_Homo sapiens_hsa049130.76935485
84Wnt signaling pathway_Homo sapiens_hsa043100.76701335
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75655480
86Prostate cancer_Homo sapiens_hsa052150.75280862
87Butanoate metabolism_Homo sapiens_hsa006500.74925974
88Glioma_Homo sapiens_hsa052140.74511427
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73426891
90Gastric acid secretion_Homo sapiens_hsa049710.72909920
91Gap junction_Homo sapiens_hsa045400.71219197
92Selenocompound metabolism_Homo sapiens_hsa004500.70244592
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69227660
94Tyrosine metabolism_Homo sapiens_hsa003500.68098268
95Endocytosis_Homo sapiens_hsa041440.67535612
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66121491
97Arginine biosynthesis_Homo sapiens_hsa002200.65469688
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65350737
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64833014
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64761660
101Estrogen signaling pathway_Homo sapiens_hsa049150.64717533
102Mineral absorption_Homo sapiens_hsa049780.64475361
103Viral myocarditis_Homo sapiens_hsa054160.63769860
104Renin-angiotensin system_Homo sapiens_hsa046140.62334020
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61166474
106Cholinergic synapse_Homo sapiens_hsa047250.61146062
107Hepatitis C_Homo sapiens_hsa051600.60727372
108beta-Alanine metabolism_Homo sapiens_hsa004100.60113947
109Complement and coagulation cascades_Homo sapiens_hsa046100.59199617
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.59050585
111VEGF signaling pathway_Homo sapiens_hsa043700.59029186
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58552282
113HTLV-I infection_Homo sapiens_hsa051660.57304693
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57261467
115Pancreatic cancer_Homo sapiens_hsa052120.57260544
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.56064868
117Glucagon signaling pathway_Homo sapiens_hsa049220.55791083
118FoxO signaling pathway_Homo sapiens_hsa040680.55649077
119AMPK signaling pathway_Homo sapiens_hsa041520.55383345
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54742938
121mTOR signaling pathway_Homo sapiens_hsa041500.54728167
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.53768542
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53123741
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52612188
125Retinol metabolism_Homo sapiens_hsa008300.52464612
126Hepatitis B_Homo sapiens_hsa051610.52314081
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52219090
128Pyruvate metabolism_Homo sapiens_hsa006200.52106994
129MAPK signaling pathway_Homo sapiens_hsa040100.52018378
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51467586
131Lysosome_Homo sapiens_hsa041420.49526381
132N-Glycan biosynthesis_Homo sapiens_hsa005100.49030185
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46678500
134Galactose metabolism_Homo sapiens_hsa000520.46111846
135Cocaine addiction_Homo sapiens_hsa050300.44565152
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44044475
137HIF-1 signaling pathway_Homo sapiens_hsa040660.43065236

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