TBX20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies, including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)9.44811529
2sarcomere organization (GO:0045214)8.66262668
3myofibril assembly (GO:0030239)7.87553589
4regulation of cardioblast differentiation (GO:0051890)7.86004104
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.63029710
6cardiac muscle cell development (GO:0055013)6.99854993
7negative regulation of potassium ion transmembrane transport (GO:1901380)6.93576759
8muscle filament sliding (GO:0030049)6.91427618
9actin-myosin filament sliding (GO:0033275)6.91427618
10cardiac muscle hypertrophy (GO:0003300)6.82816483
11cardiac muscle contraction (GO:0060048)6.78452827
12regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.72167821
13cardiac cell development (GO:0055006)6.57331905
14negative regulation of cardiac muscle cell apoptotic process (GO:0010667)6.49246995
15adult heart development (GO:0007512)6.42900150
16* cardiac muscle tissue morphogenesis (GO:0055008)6.42259754
17regulation of sarcomere organization (GO:0060297)6.42094876
18striated muscle hypertrophy (GO:0014897)6.41714642
19ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.40188434
20actin-mediated cell contraction (GO:0070252)5.98395349
21regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.97478934
22regulation of actin filament-based movement (GO:1903115)5.87703120
23regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.85963256
24ventricular cardiac muscle cell action potential (GO:0086005)5.85859146
25actomyosin structure organization (GO:0031032)5.83699803
26muscle hypertrophy (GO:0014896)5.74471007
27bundle of His cell to Purkinje myocyte communication (GO:0086069)5.71331672
28regulation of relaxation of muscle (GO:1901077)5.68561026
29* muscle tissue morphogenesis (GO:0060415)5.65681866
30positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.61242319
31negative regulation of striated muscle cell apoptotic process (GO:0010664)5.54948909
32heart trabecula formation (GO:0060347)5.51503629
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.49817586
34negative regulation of myotube differentiation (GO:0010832)5.37037952
35ventricular cardiac muscle cell development (GO:0055015)5.32584325
36regulation of the force of heart contraction (GO:0002026)5.23530028
37atrioventricular valve morphogenesis (GO:0003181)5.21075014
38heart contraction (GO:0060047)5.16149638
39heart process (GO:0003015)5.16149638
40cardiac muscle adaptation (GO:0014887)5.07711881
41cardiac muscle hypertrophy in response to stress (GO:0014898)5.07711881
42muscle hypertrophy in response to stress (GO:0003299)5.07711881
43tricarboxylic acid cycle (GO:0006099)4.97431181
44regulation of striated muscle contraction (GO:0006942)4.90860968
45regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.87006617
46striated muscle contraction (GO:0006941)4.84708765
47cell communication involved in cardiac conduction (GO:0086065)4.79906720
48cell communication by electrical coupling (GO:0010644)4.79530313
49* atrial septum morphogenesis (GO:0060413)4.79310695
50regulation of striated muscle cell apoptotic process (GO:0010662)4.63631223
51negative regulation of hormone biosynthetic process (GO:0032353)4.59148614
52regulation of transforming growth factor beta2 production (GO:0032909)4.54262512
53actin filament-based movement (GO:0030048)4.51141153
54cardiac ventricle formation (GO:0003211)4.43945003
55* cardiac chamber formation (GO:0003207)4.43945003
56regulation of cardiac muscle cell apoptotic process (GO:0010665)4.42317269
57regulation of cardiac muscle contraction (GO:0055117)4.40029951
58regulation of membrane repolarization (GO:0060306)4.37573928
59positive regulation of cardiac muscle cell differentiation (GO:2000727)4.30256027
60embryonic heart tube development (GO:0035050)4.28870653
61carnitine shuttle (GO:0006853)4.26465964
62cardiac muscle cell action potential (GO:0086001)4.23605452
63regulation of cardiac muscle cell contraction (GO:0086004)4.22935142
64relaxation of cardiac muscle (GO:0055119)4.22436934
65cardiac muscle cell action potential involved in contraction (GO:0086002)4.20750787
66plasma membrane repair (GO:0001778)4.20338733
67positive regulation of ATPase activity (GO:0032781)4.17984312
68positive regulation of ATP catabolic process (GO:1903291)4.17984312
69regulation of cardioblast proliferation (GO:0003264)4.16313281
70regulation of secondary heart field cardioblast proliferation (GO:0003266)4.16313281
71regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.15273295
72regulation of cell communication by electrical coupling (GO:0010649)4.14581351
73regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.12320514
74regulation of heart rate (GO:0002027)4.07588299
75regulation of skeletal muscle contraction (GO:0014819)4.04201124
76regulation of glucocorticoid metabolic process (GO:0031943)4.03116700
77endocardial cushion development (GO:0003197)4.02132848
78cardiac muscle tissue development (GO:0048738)4.00699268
79negative regulation of hormone metabolic process (GO:0032351)3.96412632
80trabecula formation (GO:0060343)3.95012817
81cell migration involved in heart development (GO:0060973)3.89947858
82heart morphogenesis (GO:0003007)3.86640367
83* positive regulation of cardiac muscle cell proliferation (GO:0060045)3.85369325
84cardiac muscle cell proliferation (GO:0060038)3.84271776
85regulation of ATP catabolic process (GO:1903289)3.81048303
86regulation of ATPase activity (GO:0043462)3.81048303
87positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.80600732
88* positive regulation of cardiac muscle tissue growth (GO:0055023)3.74964966
89striated muscle cell development (GO:0055002)3.74226179
90* positive regulation of heart growth (GO:0060421)3.73078812
91regulation of acyl-CoA biosynthetic process (GO:0050812)3.70859118
92cardiac conduction (GO:0061337)3.70264247
93regulation of heart contraction (GO:0008016)3.69958292
94negative regulation of cardiac muscle tissue growth (GO:0055022)3.69810956
95negative regulation of heart growth (GO:0061117)3.69810956
96* positive regulation of cardiac muscle tissue development (GO:0055025)3.68429653
97fatty acid transmembrane transport (GO:1902001)3.64648846
98sarcoplasmic reticulum calcium ion transport (GO:0070296)3.64392104
99negative regulation of protein localization to cell surface (GO:2000009)3.63987897
100cellular component maintenance (GO:0043954)3.61926938
101* regulation of cardiac muscle tissue growth (GO:0055021)3.59305478
102negative regulation of potassium ion transport (GO:0043267)3.58894899
103regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.58340862
104regulation of heart rate by cardiac conduction (GO:0086091)3.57158127
105membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.56071578
106mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.51719917
107gap junction assembly (GO:0016264)3.48176806
108regulation of coenzyme metabolic process (GO:0051196)3.46277079
109regulation of cofactor metabolic process (GO:0051193)3.46277079
110* regulation of cardiac muscle tissue development (GO:0055024)3.45589485
111positive regulation of heart contraction (GO:0045823)3.41465805
112regulation of muscle contraction (GO:0006937)3.40256511
113* outflow tract septum morphogenesis (GO:0003148)3.39447368
114ATP synthesis coupled proton transport (GO:0015986)3.35817833
115energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35817833
116* regulation of cardiac muscle cell proliferation (GO:0060043)3.32439816
117regulation of cardiac muscle cell differentiation (GO:2000725)3.32251589
118striated muscle adaptation (GO:0014888)3.31264450
119negative regulation of striated muscle cell differentiation (GO:0051154)3.30443551
120regulation of tight junction assembly (GO:2000810)3.29275158
121coronary vasculature morphogenesis (GO:0060977)3.29150790
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28360548
123response to epinephrine (GO:0071871)3.28332947
124desmosome organization (GO:0002934)3.27905005
125cartilage morphogenesis (GO:0060536)3.27627263
126negative regulation of cardiac muscle hypertrophy (GO:0010614)3.26414474
127* regulation of heart growth (GO:0060420)3.25905474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EP300_21415370_ChIP-Seq_HL-1_Mouse7.31959452
2MEF2A_21415370_ChIP-Seq_HL-1_Mouse4.61909082
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.42673404
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.17838110
5* TBX20_22080862_ChIP-Seq_HEART_Mouse3.98360741
6* TBX20_22328084_ChIP-Seq_HEART_Mouse3.98360741
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.94947228
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.46553372
9GATA4_21415370_ChIP-Seq_HL-1_Mouse3.22927400
10CDX2_19796622_ChIP-Seq_MESCs_Mouse3.22099385
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.19970647
12ESR1_20079471_ChIP-ChIP_T-47D_Human3.16615706
13* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.94069423
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.92765168
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.88593144
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.65121949
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53465272
18NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.52248249
19* ISL1_27105846_Chip-Seq_CPCs_Mouse2.31900645
20SALL4_18804426_ChIP-ChIP_XEN_Mouse2.25613749
21GBX2_23144817_ChIP-Seq_PC3_Human2.13462853
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.08889190
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.07211400
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.98337820
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.90021777
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.85646287
27ZNF263_19887448_ChIP-Seq_K562_Human1.83238573
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.80830147
29* EED_16625203_ChIP-ChIP_MESCs_Mouse1.71805313
30CJUN_26792858_Chip-Seq_BT549_Human1.70534492
31CLOCK_20551151_ChIP-Seq_293T_Human1.70236243
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65279835
33* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64830289
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61654257
35* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60111561
36* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60111561
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54217104
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.54157413
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.53139925
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.49921360
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.49694148
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.49024901
43* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42531004
44BCAT_22108803_ChIP-Seq_LS180_Human1.42161364
45* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40909879
46GATA1_22025678_ChIP-Seq_K562_Human1.37918446
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32933784
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31357301
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30701503
50* RNF2_27304074_Chip-Seq_ESCs_Mouse1.30683004
51* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29710934
52* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28754371
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28540694
54* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25483043
55NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25096452
56* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24622650
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23735849
58SOX9_26525672_Chip-Seq_HEART_Mouse1.23042801
59TP53_16413492_ChIP-PET_HCT116_Human1.22208835
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21822339
61* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21720985
62TAF15_26573619_Chip-Seq_HEK293_Human1.21366707
63* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18571270
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16824915
65* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16007873
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13711781
67SMAD3_21741376_ChIP-Seq_HESCs_Human1.13681336
68* EZH2_27294783_Chip-Seq_ESCs_Mouse1.12627950
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11366552
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10490226
71P300_19829295_ChIP-Seq_ESCs_Human1.10259276
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09752320
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09545011
74TCF4_18268006_ChIP-ChIP_LS174T_Human1.09050313
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08680822
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08136242
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.06622691
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06412935
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06333736
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05736293
81* RING1B_27294783_Chip-Seq_NPCs_Mouse1.05278290
82TP63_17297297_ChIP-ChIP_HaCaT_Human1.05123483
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05122979
84BRD4_25478319_ChIP-Seq_HGPS_Human1.04707727
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.02506374
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02101520
87SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01610512
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01284126
89* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01215916
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01137214
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01137214
92STAT3_23295773_ChIP-Seq_U87_Human1.00947989
93TCF4_23295773_ChIP-Seq_U87_Human0.99137534
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.98934884
95* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98880509
96VDR_22108803_ChIP-Seq_LS180_Human0.97903306
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97178272
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.96630354
99ZNF274_21170338_ChIP-Seq_K562_Hela0.95468493
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95424253
101PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95424144
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93864632
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93265243
104TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92777316
105ESR1_21235772_ChIP-Seq_MCF-7_Human0.92729014
106* RING1B_27294783_Chip-Seq_ESCs_Mouse0.92546053
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89448903
108SMAD4_21799915_ChIP-Seq_A2780_Human0.86590125
109PIAS1_25552417_ChIP-Seq_VCAP_Human0.86506991
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85756758
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85756758
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84057212
113PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82941879
114WT1_25993318_ChIP-Seq_PODOCYTE_Human0.81808475
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81345876
116TBL1_22424771_ChIP-Seq_293T_Human0.80749085
117SALL1_21062744_ChIP-ChIP_HESCs_Human0.80346985
118AHR_22903824_ChIP-Seq_MCF-7_Human0.79965831
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.79923522
120LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79865140
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79658214
122* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.78793580
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78497609
124SRF_21415370_ChIP-Seq_HL-1_Mouse0.78274319
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77314524
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75828691
127GATA1_19941826_ChIP-Seq_K562_Human0.75806867
128* SOX2_21211035_ChIP-Seq_LN229_Gbm0.75752889
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75619442
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.75205944
131NFYA_21822215_ChIP-Seq_K562_Human0.74966802
132GF1_26923725_Chip-Seq_HPCs_Mouse0.74807925
133SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74452744
134PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.71711598
135FOXA2_19822575_ChIP-Seq_HepG2_Human0.71360542
136* EZH2_27304074_Chip-Seq_ESCs_Mouse0.69179869
137TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.69133926
138EZH2_22144423_ChIP-Seq_EOC_Human0.68740740
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.68685670
140ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.68682568
141SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.67835192
142TBX3_20139965_ChIP-Seq_ESCs_Mouse0.67808666
143TP63_23658742_ChIP-Seq_EP156T_Human0.66781987
144* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.66767392
145PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.66429556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.62303671
2MP0002837_dystrophic_cardiac_calcinosis4.92616861
3MP0004215_abnormal_myocardial_fiber4.73266620
4MP0004036_abnormal_muscle_relaxation4.26493777
5MP0000751_myopathy3.96821537
6* MP0005330_cardiomyopathy3.89260361
7MP0008775_abnormal_heart_ventricle3.52577583
8* MP0002972_abnormal_cardiac_muscle3.46133678
9MP0003137_abnormal_impulse_conducting3.30960017
10MP0000749_muscle_degeneration3.29934702
11MP0003646_muscle_fatigue3.10702588
12MP0003828_pulmonary_edema3.07371039
13MP0002102_abnormal_ear_morphology3.00087064
14MP0010630_abnormal_cardiac_muscle2.91042401
15MP0006138_congestive_heart_failure2.88971968
16MP0004087_abnormal_muscle_fiber2.77381734
17* MP0005385_cardiovascular_system_phenoty2.74764500
18* MP0001544_abnormal_cardiovascular_syste2.74764500
19* MP0005620_abnormal_muscle_contractility2.69462449
20MP0004085_abnormal_heartbeat2.58410930
21MP0002127_abnormal_cardiovascular_syste2.56285728
22MP0004484_altered_response_of2.36896448
23MP0004510_myositis2.32780992
24MP0000750_abnormal_muscle_regeneration2.22529102
25MP0003221_abnormal_cardiomyocyte_apopto2.22314452
26MP0005503_abnormal_tendon_morphology2.14238977
27* MP0002106_abnormal_muscle_physiology2.06125970
28MP0010368_abnormal_lymphatic_system1.99176536
29* MP0003567_abnormal_fetal_cardiomyocyte1.93602824
30MP0004272_abnormal_basement_membrane1.90010226
31MP0003950_abnormal_plasma_membrane1.84986284
32MP0002269_muscular_atrophy1.81566160
33MP0004145_abnormal_muscle_electrophysio1.79860446
34* MP0005369_muscle_phenotype1.77408534
35MP0003279_aneurysm1.75078524
36MP0005451_abnormal_body_composition1.74680290
37MP0008438_abnormal_cutaneous_collagen1.70408996
38MP0003122_maternal_imprinting1.68595844
39MP0004130_abnormal_muscle_cell1.60481608
40MP0009384_cardiac_valve_regurgitation1.58855996
41MP0004233_abnormal_muscle_weight1.47085722
42MP0003566_abnormal_cell_adhesion1.45605035
43MP0005623_abnormal_meninges_morphology1.43166813
44* MP0000266_abnormal_heart_morphology1.39302428
45MP0000747_muscle_weakness1.38386726
46MP0000759_abnormal_skeletal_muscle1.34852642
47MP0000462_abnormal_digestive_system1.27736215
48MP0005248_abnormal_Harderian_gland1.22302696
49MP0005275_abnormal_skin_tensile1.17117972
50MP0003941_abnormal_skin_development1.12971835
51MP0008004_abnormal_stomach_pH1.10603903
52MP0002108_abnormal_muscle_morphology1.08288927
53MP0003123_paternal_imprinting1.04952587
54MP0002234_abnormal_pharynx_morphology1.03113390
55MP0001661_extended_life_span1.02189359
56MP0000767_abnormal_smooth_muscle1.00570062
57* MP0002128_abnormal_blood_circulation0.99316270
58MP0006036_abnormal_mitochondrial_physio0.98620452
59MP0003705_abnormal_hypodermis_morpholog0.95609691
60MP0003121_genomic_imprinting0.93427007
61MP0001879_abnormal_lymphatic_vessel0.91744402
62* MP0002088_abnormal_embryonic_growth/wei0.91325944
63* MP0003984_embryonic_growth_retardation0.90349400
64MP0002249_abnormal_larynx_morphology0.88046340
65MP0005165_increased_susceptibility_to0.87626989
66MP0005377_hearing/vestibular/ear_phenot0.85763054
67MP0003878_abnormal_ear_physiology0.85763054
68* MP0002925_abnormal_cardiovascular_devel0.85414490
69MP0002697_abnormal_eye_size0.84102246
70MP0000534_abnormal_ureter_morphology0.83475457
71MP0002332_abnormal_exercise_endurance0.83130367
72MP0000343_altered_response_to0.79433106
73MP0000230_abnormal_systemic_arterial0.72710188
74MP0006035_abnormal_mitochondrial_morpho0.72645523
75* MP0001784_abnormal_fluid_regulation0.67337353
76* MP0001672_abnormal_embryogenesis/_devel0.65903013
77* MP0005380_embryogenesis_phenotype0.65903013
78MP0005187_abnormal_penis_morphology0.65346506
79MP0003890_abnormal_embryonic-extraembry0.65062357
80MP0001299_abnormal_eye_distance/0.64101929
81MP0000733_abnormal_muscle_development0.61993661
82* MP0001614_abnormal_blood_vessel0.61371683
83MP0009697_abnormal_copulation0.59944507
84MP0003935_abnormal_craniofacial_develop0.52833351
85MP0003115_abnormal_respiratory_system0.51220957
86MP0005388_respiratory_system_phenotype0.51186922
87MP0002133_abnormal_respiratory_system0.51186922
88MP0001958_emphysema0.50370863
89MP0003119_abnormal_digestive_system0.49889588
90MP0005197_abnormal_uvea_morphology0.48942447
91MP0005670_abnormal_white_adipose0.48824365
92MP0002233_abnormal_nose_morphology0.48819082
93MP0005595_abnormal_vascular_smooth0.48174358
94MP0000762_abnormal_tongue_morphology0.47983605
95MP0000428_abnormal_craniofacial_morphol0.46512828
96MP0005666_abnormal_adipose_tissue0.46343609
97MP0002084_abnormal_developmental_patter0.45304799
98MP0003942_abnormal_urinary_system0.43760450
99MP0005508_abnormal_skeleton_morphology0.43505238
100MP0001697_abnormal_embryo_size0.43329029
101MP0001175_abnormal_lung_morphology0.43220157
102* MP0002086_abnormal_extraembryonic_tissu0.43151438
103MP0002009_preneoplasia0.40888198
104MP0006072_abnormal_retinal_apoptosis0.40437317
105MP0002109_abnormal_limb_morphology0.40362243
106MP0002085_abnormal_embryonic_tissue0.38502250
107MP0002933_joint_inflammation0.37277502
108* MP0001730_embryonic_growth_arrest0.37198412
109MP0004197_abnormal_fetal_growth/weight/0.36603309
110MP0005266_abnormal_metabolism0.36190910
111MP0005171_absent_coat_pigmentation0.36121593
112MP0002115_abnormal_skeleton_extremities0.34956484
113MP0009250_abnormal_appendicular_skeleto0.34427670
114MP0003948_abnormal_gas_homeostasis0.34354643
115MP0009672_abnormal_birth_weight0.34025800
116MP0003937_abnormal_limbs/digits/tail_de0.33799311
117MP0000516_abnormal_urinary_system0.33777094
118MP0005367_renal/urinary_system_phenotyp0.33777094
119MP0010030_abnormal_orbit_morphology0.29189169
120MP0002295_abnormal_pulmonary_circulatio0.28184325
121MP0005375_adipose_tissue_phenotype0.27335014
122* MP0003385_abnormal_body_wall0.23856412
123MP0000537_abnormal_urethra_morphology0.23820773

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)9.31154136
2Ventricular tachycardia (HP:0004756)7.23595173
3Atrial fibrillation (HP:0005110)6.90008182
4Primary atrial arrhythmia (HP:0001692)6.42149399
5Abnormality of the left ventricular outflow tract (HP:0011103)6.25832009
6Subaortic stenosis (HP:0001682)6.25832009
7Supraventricular tachycardia (HP:0004755)6.19634745
8Supraventricular arrhythmia (HP:0005115)6.10352584
9Lipoatrophy (HP:0100578)5.95578932
10Syncope (HP:0001279)5.93722632
11Right ventricular cardiomyopathy (HP:0011663)5.87077907
12Calf muscle hypertrophy (HP:0008981)5.17280032
13Abnormality of the calf musculature (HP:0001430)5.14132082
14Prolonged QT interval (HP:0001657)5.06302831
15Ventricular arrhythmia (HP:0004308)4.99921392
16Exercise-induced muscle cramps (HP:0003710)4.98343924
17Muscle fiber splitting (HP:0003555)4.96581296
18Dilated cardiomyopathy (HP:0001644)4.66777677
19Muscle hypertrophy of the lower extremities (HP:0008968)4.51448287
20Ventricular fibrillation (HP:0001663)4.35069955
21Palpitations (HP:0001962)4.23975862
22Atrioventricular block (HP:0001678)4.09813377
23Hyporeflexia of lower limbs (HP:0002600)4.03670356
24Exercise-induced myalgia (HP:0003738)3.97686886
25Hypoplastic left heart (HP:0004383)3.96922881
26Bundle branch block (HP:0011710)3.94740252
27Heart block (HP:0012722)3.80905917
28Asymmetric septal hypertrophy (HP:0001670)3.77290849
29EMG: myopathic abnormalities (HP:0003458)3.75527034
30Abnormal EKG (HP:0003115)3.74695624
31Abnormal atrioventricular conduction (HP:0005150)3.66358889
32Double outlet right ventricle (HP:0001719)3.39489033
33Congenital malformation of the right heart (HP:0011723)3.39489033
34Myoglobinuria (HP:0002913)3.38948337
35Partial duplication of thumb phalanx (HP:0009944)3.07022909
36Left ventricular hypertrophy (HP:0001712)3.06470741
37Hypoplastic heart (HP:0001961)3.03864216
38Vitreoretinal degeneration (HP:0000655)3.01445441
39Abnormality of the ischium (HP:0003174)2.91939250
40Palmoplantar keratoderma (HP:0000982)2.87763526
41Ragged-red muscle fibers (HP:0003200)2.86546597
42Partial duplication of the phalanx of hand (HP:0009999)2.73662024
43Pulmonary artery stenosis (HP:0004415)2.73607069
44Rhabdomyolysis (HP:0003201)2.71904090
45Limited hip movement (HP:0008800)2.71017680
46Increased connective tissue (HP:0009025)2.69232137
47Centrally nucleated skeletal muscle fibers (HP:0003687)2.55803709
48Periauricular skin pits (HP:0100277)2.51236762
49Preauricular pit (HP:0004467)2.51236762
50Type 1 muscle fiber predominance (HP:0003803)2.50153469
51Sudden cardiac death (HP:0001645)2.49583689
52Metaphyseal cupping (HP:0003021)2.48816826
53Abnormality of the tricuspid valve (HP:0001702)2.43189976
54Hypoglycemic coma (HP:0001325)2.37736046
55Bicuspid aortic valve (HP:0001647)2.29543604
56Abnormal ventriculo-arterial connection (HP:0011563)2.28012136
57Transposition of the great arteries (HP:0001669)2.28012136
58Abnormal connection of the cardiac segments (HP:0011545)2.28012136
59Myotonia (HP:0002486)2.27980024
60Neck muscle weakness (HP:0000467)2.26288932
61Congestive heart failure (HP:0001635)2.22317533
62Hepatic necrosis (HP:0002605)2.18268299
63Abnormal tarsal ossification (HP:0008369)2.15376105
64Arterial tortuosity (HP:0005116)2.15100088
65Abnormal pancreas size (HP:0012094)2.14543833
66Abnormal mitochondria in muscle tissue (HP:0008316)2.14018516
67Abnormality of the phalanges of the 2nd finger (HP:0009541)2.13071785
68Neoplasm of the adrenal gland (HP:0100631)2.11867646
69Acute necrotizing encephalopathy (HP:0006965)2.10089357
70Broad metatarsal (HP:0001783)2.09183252
71Mildly elevated creatine phosphokinase (HP:0008180)2.08245686
72Abnormality of the foot musculature (HP:0001436)2.07300600
73Distal lower limb muscle weakness (HP:0009053)2.06261304
74Delayed epiphyseal ossification (HP:0002663)2.03228204
75Truncus arteriosus (HP:0001660)2.01762089
76Generalized muscle weakness (HP:0003324)2.01675376
77Neonatal hypoglycemia (HP:0001998)2.00144760
78Vascular tortuosity (HP:0004948)1.99793585
79Midline defect of the nose (HP:0004122)1.99622060
80Skin pits (HP:0100276)1.97717851
81Difficulty climbing stairs (HP:0003551)1.88934193
82Abnormality of the pubic bones (HP:0003172)1.88437747
83Preaxial foot polydactyly (HP:0001841)1.86147046
84Conjunctival hamartoma (HP:0100780)1.85432577
85Abnormality of the aortic arch (HP:0012303)1.84426754
86Rimmed vacuoles (HP:0003805)1.84084944
87Hyperglycemia (HP:0003074)1.83360675
88Mitral valve prolapse (HP:0001634)1.79357979
89Protrusio acetabuli (HP:0003179)1.78900579
90EMG: neuropathic changes (HP:0003445)1.77590257
91Subacute progressive viral hepatitis (HP:0006572)1.77460440
92Diaphragmatic weakness (HP:0009113)1.76340637
93Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75960004
94Dicarboxylic aciduria (HP:0003215)1.75960004
95Scapular winging (HP:0003691)1.75280712
96Underdeveloped supraorbital ridges (HP:0009891)1.74766906
97Muscular dystrophy (HP:0003560)1.74229302
98Abnormality of the fingertips (HP:0001211)1.74044625
99Aplasia involving bones of the upper limbs (HP:0009823)1.73494956
100Aplasia of the phalanges of the hand (HP:0009802)1.73494956
101Aplasia involving bones of the extremities (HP:0009825)1.73494956
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73176715
103Abnormality of alanine metabolism (HP:0010916)1.73176715
104Hyperalaninemia (HP:0003348)1.73176715
105Visceral angiomatosis (HP:0100761)1.72349212
106Premature rupture of membranes (HP:0001788)1.71745665
107Increased CSF lactate (HP:0002490)1.71720904
108Exercise intolerance (HP:0003546)1.71689578
109Hepatocellular necrosis (HP:0001404)1.70184606
110Pheochromocytoma (HP:0002666)1.69488954
111Progressive macrocephaly (HP:0004481)1.68501883
112Duplication of thumb phalanx (HP:0009942)1.67927085
113Acute encephalopathy (HP:0006846)1.66938033
114Mitochondrial inheritance (HP:0001427)1.65783521
115Areflexia of lower limbs (HP:0002522)1.65145869
116Ketoacidosis (HP:0001993)1.64110002
117Hip contracture (HP:0003273)1.63977331
118Neonatal death (HP:0003811)1.62673080
119Hemangiomatosis (HP:0007461)1.62211160
120Cerebral edema (HP:0002181)1.62057386
121Skull defect (HP:0001362)1.61987017
122Foot dorsiflexor weakness (HP:0009027)1.61934536
123Aneurysm (HP:0002617)1.61555548
124Hypoplastic ischia (HP:0003175)1.61246653
125Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.60781284
126Bradycardia (HP:0001662)1.60558196
127Ankle contracture (HP:0006466)1.59244160
128Abnormality of fatty-acid metabolism (HP:0004359)1.59221583
129Bell-shaped thorax (HP:0001591)1.59079610
130Lymphangioma (HP:0100764)1.58768678
131* Patent foramen ovale (HP:0001655)1.57606851
132Choanal stenosis (HP:0000452)1.57292946
133Abnormality of glycolysis (HP:0004366)1.54968492
134Mixed hearing impairment (HP:0000410)1.54193548
135Aortic dissection (HP:0002647)1.53358505
136Steppage gait (HP:0003376)1.52874575
137Aplasia of the musculature (HP:0100854)1.48552165
138Abnormal foot bone ossification (HP:0010675)1.47628777
139Maternal diabetes (HP:0009800)1.44046621
140Abnormality of the lacrimal duct (HP:0011481)1.43828692
141Neonatal short-limb short stature (HP:0008921)1.42547005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.23554952
2STK245.41649864
3MYLK4.54774366
4PKN23.47831074
5DMPK3.16831200
6ZAK3.12126701
7TTN2.87926311
8STK38L2.86198515
9LMTK22.72596914
10TIE12.67750691
11PDK32.65858897
12PDK42.65858897
13PIK3CA2.53637739
14NEK12.37457791
15PHKG22.14554634
16PHKG12.14554634
17ILK1.97742999
18CDC42BPA1.63968779
19PDK21.57143738
20WNK41.49646534
21INSRR1.49329054
22TRIB31.44520322
23TRPM71.43138368
24FLT31.37576598
25GRK71.28678942
26PAK31.24402324
27MAP3K101.20768931
28CAMK2D1.18176928
29ROCK11.18150300
30MAP3K51.16915104
31RET1.15821228
32STK41.14108756
33MUSK1.08489556
34STK31.08171751
35DAPK31.06501451
36WNK10.97404596
37LATS10.96723487
38PRKD10.93273403
39PLK40.92151876
40DDR20.91227157
41BCKDK0.90426937
42PINK10.85619599
43LIMK10.83718206
44ERBB40.82181638
45PDGFRA0.81681740
46KDR0.80172870
47PTK2B0.77443789
48PRKAA10.75665394
49MAPKAPK30.73631197
50PRKAA20.68817856
51CAMK40.68798484
52AKT30.67799616
53MAP3K70.66748992
54MAPK120.64062930
55NUAK10.63754097
56FGFR20.63255304
57CAMK10.62398290
58FRK0.62269522
59NEK90.62122923
60ICK0.62046408
61RIPK10.59726981
62BCR0.56290505
63TGFBR10.55953346
64LATS20.55366789
65TNIK0.54563912
66CAMK2A0.53690633
67TGFBR20.52156680
68PRKCE0.51462544
69PRKD30.47954847
70EPHB20.47224247
71PRKACB0.47190946
72MAP3K30.47158819
73STK380.46488211
74STK390.46181406
75PAK20.44530230
76EEF2K0.44292456
77MAP3K60.40813445
78CDK40.39936504
79ROCK20.39810419
80PLK20.38306712
81NLK0.38257571
82PRKACA0.37954564
83MAPK40.36894617
84PDK10.34084458
85RPS6KL10.33946713
86RPS6KC10.33946713
87AKT20.31866501
88PRKACG0.30486864
89FGFR10.29042401
90MAP2K30.28392578
91PKN10.27787971
92MAPK70.27566679
93PRKG10.27472724
94SGK20.25651715
95MELK0.25092677
96TTK0.24217337
97PTK20.23341293
98CAMK2G0.22912490
99MAPK100.22699919
100RPS6KA60.22530441
101MET0.22401575
102MARK30.22340839
103BRD40.21396337
104AURKB0.18759845
105RPS6KB20.18628145
106MTOR0.18535575
107NEK20.17460803
108FER0.17394554
109SCYL20.17074935
110SGK30.16999559
111MARK10.15704902
112AKT10.15607526
113ADRBK10.15065562
114PTK60.14934232
115TESK10.14872592
116MARK20.14792636
117PRKDC0.14666307
118DYRK1B0.13388825
119PRKG20.13216095
120RPS6KA10.13046542
121BRSK20.12018925
122ACVR1B0.11989221
123PRPF4B0.10399080
124PRKCQ0.10164110
125IGF1R0.07750587
126PDGFRB0.07726688
127UHMK10.07533275

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.67181972
2Cardiac muscle contraction_Homo sapiens_hsa042605.03667813
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054105.01364365
4Dilated cardiomyopathy_Homo sapiens_hsa054144.87279809
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.77289849
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.34065518
7Parkinsons disease_Homo sapiens_hsa050122.83463224
8Oxidative phosphorylation_Homo sapiens_hsa001902.55394870
9Propanoate metabolism_Homo sapiens_hsa006402.48745238
10Fatty acid degradation_Homo sapiens_hsa000712.38296634
11Carbon metabolism_Homo sapiens_hsa012002.27884366
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.27508002
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.17335186
14Viral myocarditis_Homo sapiens_hsa054162.01357540
15Alzheimers disease_Homo sapiens_hsa050101.89746245
16Huntingtons disease_Homo sapiens_hsa050161.89687607
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70401490
18Fatty acid metabolism_Homo sapiens_hsa012121.68797190
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60582235
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.39152755
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35549485
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34577049
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34444227
24Pyruvate metabolism_Homo sapiens_hsa006201.27800797
25ECM-receptor interaction_Homo sapiens_hsa045121.21703097
26Focal adhesion_Homo sapiens_hsa045101.19957563
27Adherens junction_Homo sapiens_hsa045201.15719903
28Tight junction_Homo sapiens_hsa045301.11823406
29Starch and sucrose metabolism_Homo sapiens_hsa005001.10517049
30Biosynthesis of amino acids_Homo sapiens_hsa012301.10228761
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08808158
32Glucagon signaling pathway_Homo sapiens_hsa049221.08467242
33Insulin resistance_Homo sapiens_hsa049311.06127994
34Fatty acid elongation_Homo sapiens_hsa000621.05392532
35HIF-1 signaling pathway_Homo sapiens_hsa040661.02192302
36Galactose metabolism_Homo sapiens_hsa000520.85379844
37Endometrial cancer_Homo sapiens_hsa052130.84169852
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81128152
39Insulin signaling pathway_Homo sapiens_hsa049100.75639645
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.75305678
41Butanoate metabolism_Homo sapiens_hsa006500.74792478
42Lysine degradation_Homo sapiens_hsa003100.74651568
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73358707
44Taste transduction_Homo sapiens_hsa047420.73275442
45Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65932838
46Amoebiasis_Homo sapiens_hsa051460.65116800
47Phenylalanine metabolism_Homo sapiens_hsa003600.64912776
48Oxytocin signaling pathway_Homo sapiens_hsa049210.63171221
49Pancreatic secretion_Homo sapiens_hsa049720.63017385
50Calcium signaling pathway_Homo sapiens_hsa040200.62913381
51Circadian rhythm_Homo sapiens_hsa047100.62028274
52Cholinergic synapse_Homo sapiens_hsa047250.61616710
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.61164346
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.60932639
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.57637114
56Proteoglycans in cancer_Homo sapiens_hsa052050.57268841
57Tryptophan metabolism_Homo sapiens_hsa003800.57123282
58PPAR signaling pathway_Homo sapiens_hsa033200.56388281
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54695908
60Fructose and mannose metabolism_Homo sapiens_hsa000510.53919409
61Tyrosine metabolism_Homo sapiens_hsa003500.53397275
62AMPK signaling pathway_Homo sapiens_hsa041520.53319938
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50840143
64Gastric acid secretion_Homo sapiens_hsa049710.50785938
65Systemic lupus erythematosus_Homo sapiens_hsa053220.50093237
66Small cell lung cancer_Homo sapiens_hsa052220.49777096
67Hippo signaling pathway_Homo sapiens_hsa043900.49534327
68beta-Alanine metabolism_Homo sapiens_hsa004100.49137133
69Gap junction_Homo sapiens_hsa045400.48441550
70cAMP signaling pathway_Homo sapiens_hsa040240.46961133
71Mineral absorption_Homo sapiens_hsa049780.46941010
72Arginine and proline metabolism_Homo sapiens_hsa003300.46125676
73TGF-beta signaling pathway_Homo sapiens_hsa043500.45247198
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43797211
75Alcoholism_Homo sapiens_hsa050340.43517235
76Melanoma_Homo sapiens_hsa052180.41257445
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38529400
78Axon guidance_Homo sapiens_hsa043600.37243130
79Bile secretion_Homo sapiens_hsa049760.35564117
80GnRH signaling pathway_Homo sapiens_hsa049120.35258121
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.32177263
82Malaria_Homo sapiens_hsa051440.31736160
83Amphetamine addiction_Homo sapiens_hsa050310.31057315
84Protein digestion and absorption_Homo sapiens_hsa049740.29599432
85Renin secretion_Homo sapiens_hsa049240.28654110
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28473712
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28162104
88Type II diabetes mellitus_Homo sapiens_hsa049300.26655440
89Thyroid hormone synthesis_Homo sapiens_hsa049180.25815327
90Ovarian steroidogenesis_Homo sapiens_hsa049130.25772369
91Colorectal cancer_Homo sapiens_hsa052100.25164647
92Rap1 signaling pathway_Homo sapiens_hsa040150.25154926
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24541545
94Arginine biosynthesis_Homo sapiens_hsa002200.24459435
95FoxO signaling pathway_Homo sapiens_hsa040680.24355920
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23669020
97Circadian entrainment_Homo sapiens_hsa047130.22679434
98Serotonergic synapse_Homo sapiens_hsa047260.22200108
99GABAergic synapse_Homo sapiens_hsa047270.21167393
100Metabolic pathways_Homo sapiens_hsa011000.20154302
101Insulin secretion_Homo sapiens_hsa049110.19754735
102Pathways in cancer_Homo sapiens_hsa052000.19728366
103Prion diseases_Homo sapiens_hsa050200.19673319
104Cocaine addiction_Homo sapiens_hsa050300.19411365
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19300186
106Pancreatic cancer_Homo sapiens_hsa052120.19223730
107Platelet activation_Homo sapiens_hsa046110.18138030
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15461374
109Basal cell carcinoma_Homo sapiens_hsa052170.15180413
110Proteasome_Homo sapiens_hsa030500.14804652
111MicroRNAs in cancer_Homo sapiens_hsa052060.13849253
112Renal cell carcinoma_Homo sapiens_hsa052110.11598538
113Hedgehog signaling pathway_Homo sapiens_hsa043400.09747325
114Toxoplasmosis_Homo sapiens_hsa051450.09258732
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.08772551
116Peroxisome_Homo sapiens_hsa041460.08372097
117Melanogenesis_Homo sapiens_hsa049160.08348253
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08288540
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.08031915
120mTOR signaling pathway_Homo sapiens_hsa041500.07498419
121HTLV-I infection_Homo sapiens_hsa051660.07051243
122Wnt signaling pathway_Homo sapiens_hsa043100.06766454
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.06620662
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.04321225
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.04229759
126Purine metabolism_Homo sapiens_hsa002300.01355388
127Pentose phosphate pathway_Homo sapiens_hsa000300.01159534

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