TBX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucocorticoid biosynthetic process (GO:0006704)5.35935767
2endocardial cushion development (GO:0003197)5.16368930
3intestinal epithelial cell development (GO:0060576)5.15359362
4purine nucleobase biosynthetic process (GO:0009113)4.68771375
5vitamin transmembrane transport (GO:0035461)4.34596052
6cell migration involved in heart development (GO:0060973)4.31508071
7nucleobase biosynthetic process (GO:0046112)4.22551398
8basement membrane organization (GO:0071711)4.06668870
9glucocorticoid metabolic process (GO:0008211)4.05773202
10folic acid metabolic process (GO:0046655)3.99603112
11serine family amino acid catabolic process (GO:0009071)3.84295150
12establishment of apical/basal cell polarity (GO:0035089)3.76732348
13sulfur amino acid catabolic process (GO:0000098)3.74832004
14chondrocyte proliferation (GO:0035988)3.70636382
15regulation of posttranscriptional gene silencing (GO:0060147)3.65935888
16regulation of gene silencing by miRNA (GO:0060964)3.65935888
17regulation of gene silencing by RNA (GO:0060966)3.65935888
18negative regulation of fatty acid transport (GO:2000192)3.65422345
19vascular endothelial growth factor signaling pathway (GO:0038084)3.65370232
20notochord development (GO:0030903)3.61556188
21paraxial mesoderm development (GO:0048339)3.56853061
22trophectodermal cell differentiation (GO:0001829)3.56419215
23glycine metabolic process (GO:0006544)3.56198735
24desmosome organization (GO:0002934)3.52206492
25ribosome assembly (GO:0042255)3.49948465
26atrioventricular valve morphogenesis (GO:0003181)3.49362608
27endothelial cell morphogenesis (GO:0001886)3.44570285
28skin morphogenesis (GO:0043589)3.33920542
29collagen fibril organization (GO:0030199)3.33876586
30modified amino acid transport (GO:0072337)3.27003903
31positive regulation of SMAD protein import into nucleus (GO:0060391)3.25322879
32response to follicle-stimulating hormone (GO:0032354)3.24426797
33* anterior/posterior axis specification, embryo (GO:0008595)3.23700697
34insulin-like growth factor receptor signaling pathway (GO:0048009)3.23200959
35branching involved in prostate gland morphogenesis (GO:0060442)3.22802409
36Golgi transport vesicle coating (GO:0048200)3.19073048
37COPI coating of Golgi vesicle (GO:0048205)3.19073048
38protein heterotrimerization (GO:0070208)3.16385798
39cysteine metabolic process (GO:0006534)3.12468870
40polarized epithelial cell differentiation (GO:0030859)3.11924448
41regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.09528203
42regulation of hippo signaling (GO:0035330)3.08773516
43adherens junction assembly (GO:0034333)3.08311711
44formation of translation preinitiation complex (GO:0001731)3.06783147
45establishment or maintenance of monopolar cell polarity (GO:0061339)3.04995031
46establishment of monopolar cell polarity (GO:0061162)3.04995031
47cell-substrate junction assembly (GO:0007044)3.04165318
48intestinal cholesterol absorption (GO:0030299)3.03038889
49iron ion import (GO:0097286)3.01471339
50lung vasculature development (GO:0060426)3.00746313
51regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.00737102
52cell migration involved in sprouting angiogenesis (GO:0002042)3.00246508
53pericardium development (GO:0060039)2.98356580
54androgen biosynthetic process (GO:0006702)2.97784783
55cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.97654002
56serine family amino acid metabolic process (GO:0009069)2.96004763
57hormone catabolic process (GO:0042447)2.95782506
58COPII vesicle coating (GO:0048208)2.95596088
59regulation of spindle organization (GO:0090224)2.93578027
60mitotic metaphase plate congression (GO:0007080)2.93035949
61labyrinthine layer development (GO:0060711)2.92839259
62regulation of SMAD protein import into nucleus (GO:0060390)2.92669618
63endodermal cell differentiation (GO:0035987)2.92557391
64blood vessel endothelial cell migration (GO:0043534)2.90957565
65lung-associated mesenchyme development (GO:0060484)2.90566502
66cell-substrate adherens junction assembly (GO:0007045)2.89943757
67focal adhesion assembly (GO:0048041)2.89943757
68proline biosynthetic process (GO:0006561)2.89929485
69vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.84523189
70regulation of mitotic spindle organization (GO:0060236)2.82635903
71regulation of plasminogen activation (GO:0010755)2.79824490
72positive regulation of blood vessel endothelial cell migration (GO:0043536)2.79376912
73intestinal absorption (GO:0050892)2.77611065
74adhesion of symbiont to host (GO:0044406)2.77218695
75vitamin transport (GO:0051180)2.76682895
76positive regulation of fatty acid beta-oxidation (GO:0032000)2.76644182
77regulation of cardioblast differentiation (GO:0051890)2.75825000
78folic acid transport (GO:0015884)2.74222466
79cellular response to antibiotic (GO:0071236)2.73016174
80negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.72957825
81biotin metabolic process (GO:0006768)2.72911405
82embryonic process involved in female pregnancy (GO:0060136)2.72621402
83ribosome biogenesis (GO:0042254)2.71772319
84transcription from mitochondrial promoter (GO:0006390)2.70780675
85regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.70516119
86serine family amino acid biosynthetic process (GO:0009070)2.70513823
87sequestering of extracellular ligand from receptor (GO:0035581)2.70171111
88mesenchymal-epithelial cell signaling (GO:0060638)2.69478152
89angiotensin maturation (GO:0002003)2.67984726
90endothelial cell chemotaxis (GO:0035767)2.67761042
91hypotonic response (GO:0006971)2.67356253
92C21-steroid hormone biosynthetic process (GO:0006700)2.66959980
93bone trabecula formation (GO:0060346)2.66446693
94nuclear pore organization (GO:0006999)2.65804565
95heterochromatin organization (GO:0070828)2.64253886
96pantothenate metabolic process (GO:0015939)2.64160964
97C21-steroid hormone metabolic process (GO:0008207)2.63962433
98regulation of translation in response to stress (GO:0043555)2.63695564
99embryonic placenta development (GO:0001892)2.63288181
100artery morphogenesis (GO:0048844)2.62999501
101extracellular matrix assembly (GO:0085029)2.62924339
102positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.62278238
103regulation of tight junction assembly (GO:2000810)2.62192928
104cell adhesion mediated by integrin (GO:0033627)2.60828227
105UDP-N-acetylglucosamine metabolic process (GO:0006047)2.60514711
106hippo signaling (GO:0035329)2.59818652
107regulation of transforming growth factor beta1 production (GO:0032908)2.59399484
108midgut development (GO:0007494)2.58993363
109regulation of G0 to G1 transition (GO:0070316)2.58882621
110progesterone metabolic process (GO:0042448)2.58797822
111cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.57731906
112hemidesmosome assembly (GO:0031581)2.57024761
113positive regulation of hormone metabolic process (GO:0032352)2.56978394
114neural crest cell development (GO:0014032)2.56931822
115planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56755259
116morphogenesis of an epithelial fold (GO:0060571)2.56410839
117protein localization to kinetochore (GO:0034501)2.54986801
118very-low-density lipoprotein particle assembly (GO:0034379)2.54912270
119folic acid-containing compound biosynthetic process (GO:0009396)2.54690779
120regulation of glucose import in response to insulin stimulus (GO:2001273)2.54293650
121Leydig cell differentiation (GO:0033327)2.53910782
122negative regulation of translational initiation (GO:0045947)2.53589707
123retina vasculature morphogenesis in camera-type eye (GO:0061299)2.53492648
124import into cell (GO:0098657)2.53126244
125somatic diversification of immune receptors via somatic mutation (GO:0002566)2.53126050
126somatic hypermutation of immunoglobulin genes (GO:0016446)2.53126050
127mitochondrial DNA metabolic process (GO:0032042)2.53040073
128epoxygenase P450 pathway (GO:0019373)2.52603508
129blastocyst development (GO:0001824)2.52069510
130regulation of fatty acid beta-oxidation (GO:0031998)2.51997998
131negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.51376199
132mitotic G1 DNA damage checkpoint (GO:0031571)2.51149704
133mitotic sister chromatid segregation (GO:0000070)2.50781910
134regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.50714979
135proline metabolic process (GO:0006560)2.50445218
136negative regulation of axon extension involved in axon guidance (GO:0048843)2.50117267
137kidney mesenchyme development (GO:0072074)2.49766082
138mesodermal cell differentiation (GO:0048333)2.49407123
139heme transport (GO:0015886)2.48801624
140eyelid development in camera-type eye (GO:0061029)2.47963762
141regulation of steroid hormone biosynthetic process (GO:0090030)2.47756146
142regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.46541513
143regulation of sister chromatid cohesion (GO:0007063)2.46375831
144mitotic nuclear envelope disassembly (GO:0007077)2.45970638
145negative regulation of androgen receptor signaling pathway (GO:0060766)2.44323858
146multicellular organismal macromolecule metabolic process (GO:0044259)2.43725182
147negative regulation of stem cell proliferation (GO:2000647)2.43335493
148nuclear pore complex assembly (GO:0051292)2.43199646
149negative regulation of fatty acid biosynthetic process (GO:0045717)2.42931457
150protein localization to endosome (GO:0036010)2.42123769
151regulation of integrin-mediated signaling pathway (GO:2001044)2.41078033
152regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40981863
153DNA replication checkpoint (GO:0000076)2.40883383
154epithelial cell differentiation involved in prostate gland development (GO:0060742)2.40265471
155histone H4-K12 acetylation (GO:0043983)2.39614814
156regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.39497034
157blood vessel morphogenesis (GO:0048514)2.39080485
158DNA replication-dependent nucleosome organization (GO:0034723)2.38997898
159DNA replication-dependent nucleosome assembly (GO:0006335)2.38997898
160collagen metabolic process (GO:0032963)2.38607658
161sulfur amino acid biosynthetic process (GO:0000097)2.37575433
162regulation of transforming growth factor beta2 production (GO:0032909)2.37488082
163multicellular organismal metabolic process (GO:0044236)2.37169359
164nucleotide-sugar biosynthetic process (GO:0009226)2.37157835
165trabecula formation (GO:0060343)2.37019659
166cellular response to gonadotropin stimulus (GO:0071371)2.36510265
167glomerular basement membrane development (GO:0032836)2.36396215
168GDP-mannose metabolic process (GO:0019673)2.35354383
169determination of adult lifespan (GO:0008340)2.34329177
170regulation of cholesterol homeostasis (GO:2000188)2.34101776
171regulation of bile acid biosynthetic process (GO:0070857)2.33837858
172smooth muscle tissue development (GO:0048745)2.32806016
173pyrimidine-containing compound transmembrane transport (GO:0072531)2.31309141
174homocysteine metabolic process (GO:0050667)2.31071500
175regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.30729832
176positive regulation of cartilage development (GO:0061036)2.30683615
177regulation of extracellular matrix disassembly (GO:0010715)2.30345484
178galactose catabolic process (GO:0019388)2.30174913
179protein hydroxylation (GO:0018126)2.30128691
180regulation of telomere maintenance via telomerase (GO:0032210)2.29782046
181fibroblast migration (GO:0010761)2.29207012
182outflow tract septum morphogenesis (GO:0003148)2.29068841
183adrenal gland development (GO:0030325)2.28974152
184response to gonadotropin (GO:0034698)2.27289632
185hyaluronan catabolic process (GO:0030214)2.26793394
186extracellular matrix disassembly (GO:0022617)2.26713697
187positive regulation of chromosome segregation (GO:0051984)2.26210765
188mitotic G1/S transition checkpoint (GO:0044819)2.26008825
189membrane disassembly (GO:0030397)2.25344135
190nuclear envelope disassembly (GO:0051081)2.25344135
191folic acid-containing compound metabolic process (GO:0006760)2.25095834
192apoptotic process involved in morphogenesis (GO:0060561)2.24984588
193metaphase plate congression (GO:0051310)2.24827047
194maturation of SSU-rRNA (GO:0030490)2.21981139
195maternal placenta development (GO:0001893)2.20726376
196regulation of translational fidelity (GO:0006450)2.20535362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.11172473
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.11172473
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.11172473
4E2F7_22180533_ChIP-Seq_HELA_Human4.09480848
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.73857934
6POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.34951487
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.24442882
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.19090530
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.98317182
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.89582777
11* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.89289494
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.76834652
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68971414
14* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.64254941
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63273776
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.60801907
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.59678235
18NANOG_18555785_ChIP-Seq_MESCs_Mouse2.56103067
19ZNF263_19887448_ChIP-Seq_K562_Human2.53527812
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39944926
21STAT3_1855785_ChIP-Seq_MESCs_Mouse2.31090911
22* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.28968382
23TCF3_18692474_ChIP-Seq_MESCs_Mouse2.26066317
24* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.23959354
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.19340655
26* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.12979486
27* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.07369333
28* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.05157346
29WT1_19549856_ChIP-ChIP_CCG9911_Human2.04258720
30* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.01497927
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00140024
32* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.99039992
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.97169358
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.92661343
35* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90237558
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.90089365
37BRD4_25478319_ChIP-Seq_HGPS_Human1.86425641
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85503189
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82385123
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.81173665
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80383207
42* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79031362
43SOX9_24532713_ChIP-Seq_HFSC_Mouse1.78958460
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.78309258
45* AR_21909140_ChIP-Seq_LNCAP_Human1.78153634
46* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76421523
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75635814
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75063945
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.72815116
50* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.70599820
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70248930
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69302951
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65123921
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64847450
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63903442
56SOX2_18692474_ChIP-Seq_MEFs_Mouse1.61975323
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61971606
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.60664380
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.60575951
60* EP300_21415370_ChIP-Seq_HL-1_Mouse1.58285629
61* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.56640693
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56569049
63* UBF1/2_26484160_Chip-Seq_HMECs_Human1.55525643
64* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.53975026
65* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53114484
66* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53114484
67* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.52382141
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50514837
69* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.50308118
70* FOXA2_19822575_ChIP-Seq_HepG2_Human1.49866614
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.49349521
72CJUN_26792858_Chip-Seq_BT549_Human1.48871318
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.46699854
74* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.46594683
75* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46552688
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45460424
77* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45338488
78* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44394593
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.44274053
80AHR_22903824_ChIP-Seq_MCF-7_Human1.44064551
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.43969359
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.43896010
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.42857472
84* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.41756929
85SOX2_18692474_ChIP-Seq_MESCs_Mouse1.41166989
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40918305
87CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40603830
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40368792
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40368792
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39114727
91* LXR_22158963_ChIP-Seq_LIVER_Mouse1.39063852
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.38997635
93* TBX20_22080862_ChIP-Seq_HEART_Mouse1.38195791
94* TBX20_22328084_ChIP-Seq_HEART_Mouse1.38195791
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37728066
96CLOCK_20551151_ChIP-Seq_293T_Human1.35133476
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33312806
98TP53_22127205_ChIP-Seq_IMR90_Human1.31984473
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29982200
100EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28897435
101* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28713026
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28693778
103NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.27652529
104* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26642860
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26566650
106* KAP1_27257070_Chip-Seq_ESCs_Mouse1.26494580
107* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26294105
108JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25088952
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24541208
110* SOX2_20726797_ChIP-Seq_SW620_Human1.23904550
111* SMAD_19615063_ChIP-ChIP_OVARY_Human1.23340713
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22326510
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22320543
114CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22217670
115* ISL1_27105846_Chip-Seq_CPCs_Mouse1.22204787
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.21993928
117MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21013770
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20804378
119* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.20602944
120MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19739991
121* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19647199
122EST1_17652178_ChIP-ChIP_JURKAT_Human1.19050067
123ESR2_21235772_ChIP-Seq_MCF-7_Human1.18485673
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18248567
125TP53_20018659_ChIP-ChIP_R1E_Mouse1.17703846
126ESR1_21235772_ChIP-Seq_MCF-7_Human1.17347108
127RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16748650
128EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16748650
129CDX2_20551321_ChIP-Seq_CACO-2_Human1.16659789
130CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16199487
131* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15924519
132ATF3_27146783_Chip-Seq_COLON_Human1.15453043
133TP53_18474530_ChIP-ChIP_U2OS_Human1.14383658
134KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14299793
135LXR_22292898_ChIP-Seq_THP-1_Human1.13006643
136KDM2B_26808549_Chip-Seq_K562_Human1.12923220
137YY1_21170310_ChIP-Seq_MESCs_Mouse1.12790991
138HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12470067
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12326190
140* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12058211
141* XRN2_22483619_ChIP-Seq_HELA_Human1.12038359
142* RUNX1_27514584_Chip-Seq_MCF-7_Human1.10429747
143UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09909209
144HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09907681
145E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08723786
146KDM5A_27292631_Chip-Seq_BREAST_Human1.08413254
147STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08105454
148CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07195052
149SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06583222
150TP53_16413492_ChIP-PET_HCT116_Human1.04733796
151SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04629751
152* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03684491
153* GATA6_25053715_ChIP-Seq_YYC3_Human1.03063952
154* ARNT_22903824_ChIP-Seq_MCF-7_Human1.02885866
155* GATA4_25053715_ChIP-Seq_YYC3_Human1.01631730
156* RACK7_27058665_Chip-Seq_MCF-7_Human1.01350825
157* NANOG_16518401_ChIP-PET_MESCs_Mouse0.99321596
158* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98897082
159TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97514597
160DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96067001
161KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94342056
162E2F1_21310950_ChIP-Seq_MCF-7_Human0.92632214
163* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91686942
164NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91504310
165STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90465312
166GABP_19822575_ChIP-Seq_HepG2_Human0.90214875
167ELK3_25401928_ChIP-Seq_HUVEC_Human0.90022125
168* CHD1_26751641_Chip-Seq_LNCaP_Human0.89254399
169* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87890799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.38498752
2MP0005503_abnormal_tendon_morphology3.67790232
3MP0005360_urolithiasis3.32483854
4MP0003693_abnormal_embryo_hatching2.81789973
5MP0004858_abnormal_nervous_system2.80248666
6MP0004264_abnormal_extraembryonic_tissu2.65096217
7MP0005275_abnormal_skin_tensile2.58951475
8MP0004957_abnormal_blastocyst_morpholog2.54052572
9MP0003279_aneurysm2.53435663
10MP0005257_abnormal_intraocular_pressure2.53303949
11MP0003806_abnormal_nucleotide_metabolis2.53034890
12MP0000537_abnormal_urethra_morphology2.49923485
13MP0009384_cardiac_valve_regurgitation2.47841159
14MP0001958_emphysema2.41980495
15MP0003705_abnormal_hypodermis_morpholog2.39604240
16MP0003718_maternal_effect2.27875809
17MP0002139_abnormal_hepatobiliary_system2.25277527
18MP0005085_abnormal_gallbladder_physiolo2.22807556
19MP0003111_abnormal_nucleus_morphology2.14444211
20MP0010352_gastrointestinal_tract_polyps2.12722052
21MP0003950_abnormal_plasma_membrane2.03580903
22MP0009840_abnormal_foam_cell1.96702198
23MP0009780_abnormal_chondrocyte_physiolo1.92404892
24MP0009053_abnormal_anal_canal1.90585896
25MP0005365_abnormal_bile_salt1.86868720
26MP0010234_abnormal_vibrissa_follicle1.86577845
27MP0008875_abnormal_xenobiotic_pharmacok1.78471033
28MP0001672_abnormal_embryogenesis/_devel1.77440262
29MP0005380_embryogenesis_phenotype1.77440262
30MP0003942_abnormal_urinary_system1.74807629
31MP0000516_abnormal_urinary_system1.70934085
32MP0005367_renal/urinary_system_phenotyp1.70934085
33MP0003091_abnormal_cell_migration1.70656922
34MP0003941_abnormal_skin_development1.69377690
35MP0003123_paternal_imprinting1.67402418
36MP0002653_abnormal_ependyma_morphology1.67354429
37MP0001730_embryonic_growth_arrest1.67224755
38MP0003119_abnormal_digestive_system1.63563142
39* MP0002086_abnormal_extraembryonic_tissu1.60865560
40MP0002088_abnormal_embryonic_growth/wei1.59483157
41MP0003984_embryonic_growth_retardation1.59437605
42MP0005623_abnormal_meninges_morphology1.59302657
43MP0008057_abnormal_DNA_replication1.59271647
44MP0002108_abnormal_muscle_morphology1.58294530
45MP0010030_abnormal_orbit_morphology1.57161977
46MP0001666_abnormal_nutrient_absorption1.55131719
47MP0000751_myopathy1.54617356
48MP0000767_abnormal_smooth_muscle1.54382223
49MP0006054_spinal_hemorrhage1.53529795
50MP0003077_abnormal_cell_cycle1.51371840
51MP0008004_abnormal_stomach_pH1.51062098
52MP0002896_abnormal_bone_mineralization1.48079889
53MP0003567_abnormal_fetal_cardiomyocyte1.47508706
54MP0005409_darkened_coat_color1.46362380
55MP0010094_abnormal_chromosome_stability1.46333801
56MP0005508_abnormal_skeleton_morphology1.45727453
57* MP0002085_abnormal_embryonic_tissue1.43908014
58MP0000013_abnormal_adipose_tissue1.40359030
59MP0000003_abnormal_adipose_tissue1.39581420
60MP0001697_abnormal_embryo_size1.38834722
61MP0003315_abnormal_perineum_morphology1.38778379
62MP0004019_abnormal_vitamin_homeostasis1.33286389
63* MP0002084_abnormal_developmental_patter1.32890765
64MP0002060_abnormal_skin_morphology1.32712359
65MP0002127_abnormal_cardiovascular_syste1.31250763
66MP0000350_abnormal_cell_proliferation1.28836071
67MP0004272_abnormal_basement_membrane1.27964937
68MP0000733_abnormal_muscle_development1.27777924
69MP0000538_abnormal_urinary_bladder1.27479699
70MP0005187_abnormal_penis_morphology1.27182946
71MP0010329_abnormal_lipoprotein_level1.26714326
72MP0001879_abnormal_lymphatic_vessel1.25800277
73MP0005332_abnormal_amino_acid1.25216948
74MP0000462_abnormal_digestive_system1.23323160
75MP0008932_abnormal_embryonic_tissue1.20382479
76MP0003566_abnormal_cell_adhesion1.19987032
77MP0004197_abnormal_fetal_growth/weight/1.19371177
78MP0005076_abnormal_cell_differentiation1.18439063
79* MP0002080_prenatal_lethality1.17314105
80MP0001299_abnormal_eye_distance/1.16982274
81MP0001542_abnormal_bone_strength1.16705765
82MP0003385_abnormal_body_wall1.15777337
83MP0005023_abnormal_wound_healing1.15743955
84MP0003252_abnormal_bile_duct1.14164826
85MP0005319_abnormal_enzyme/_coenzyme1.13818056
86MP0005670_abnormal_white_adipose1.12997928
87MP0002796_impaired_skin_barrier1.12038548
88MP0000681_abnormal_thyroid_gland1.11949409
89MP0004233_abnormal_muscle_weight1.11345920
90MP0003890_abnormal_embryonic-extraembry1.09224202
91MP0001756_abnormal_urination1.08994833
92MP0003786_premature_aging1.07749722
93MP0000534_abnormal_ureter_morphology1.07063734
94MP0010368_abnormal_lymphatic_system1.04866563
95* MP0009250_abnormal_appendicular_skeleto1.03755054
96MP0000762_abnormal_tongue_morphology1.03408116
97MP0002249_abnormal_larynx_morphology1.03324078
98MP0001293_anophthalmia1.01992008
99MP0003878_abnormal_ear_physiology1.01765795
100MP0005377_hearing/vestibular/ear_phenot1.01765795
101MP0006138_congestive_heart_failure1.00067007
102MP0005595_abnormal_vascular_smooth0.98795220
103MP0003868_abnormal_feces_composition0.98572535
104MP0002111_abnormal_tail_morphology0.98325896
105MP0005647_abnormal_sex_gland0.96766167
106MP0001661_extended_life_span0.96334825
107MP0005395_other_phenotype0.96200927
108MP0000613_abnormal_salivary_gland0.95971063
109MP0010386_abnormal_urinary_bladder0.95629921
110MP0002254_reproductive_system_inflammat0.94970642
111MP0001849_ear_inflammation0.94653069
112MP0004084_abnormal_cardiac_muscle0.93930310
113MP0005375_adipose_tissue_phenotype0.92926440
114MP0003283_abnormal_digestive_organ0.91084210
115MP0002295_abnormal_pulmonary_circulatio0.90162866
116MP0003115_abnormal_respiratory_system0.89669890
117MP0003828_pulmonary_edema0.87918329
118MP0000609_abnormal_liver_physiology0.86946526
119MP0000750_abnormal_muscle_regeneration0.86856887
120MP0009643_abnormal_urine_homeostasis0.85058810
121MP0004133_heterotaxia0.84497408
122* MP0002115_abnormal_skeleton_extremities0.84383032
123MP0002089_abnormal_postnatal_growth/wei0.84107278
124MP0002009_preneoplasia0.83647080
125MP0002166_altered_tumor_susceptibility0.83146385
126* MP0003937_abnormal_limbs/digits/tail_de0.82348268
127MP0005248_abnormal_Harderian_gland0.81205705
128MP0005197_abnormal_uvea_morphology0.80603928
129MP0001348_abnormal_lacrimal_gland0.80358815
130MP0000163_abnormal_cartilage_morphology0.80317989
131MP0001243_abnormal_dermal_layer0.80168269
132* MP0003935_abnormal_craniofacial_develop0.79304026
133MP0005451_abnormal_body_composition0.79251751
134* MP0002925_abnormal_cardiovascular_devel0.79102048
135MP0000639_abnormal_adrenal_gland0.78964499
136MP0000477_abnormal_intestine_morphology0.78301053
137MP0010630_abnormal_cardiac_muscle0.77909378
138MP0002128_abnormal_blood_circulation0.77802404
139* MP0003936_abnormal_reproductive_system0.77555785
140MP0000428_abnormal_craniofacial_morphol0.76358363
141MP0010307_abnormal_tumor_latency0.75835571
142* MP0001614_abnormal_blood_vessel0.75448381
143MP0002132_abnormal_respiratory_system0.75294830
144MP0002269_muscular_atrophy0.75106481
145MP0003191_abnormal_cellular_cholesterol0.74799515
146MP0002092_abnormal_eye_morphology0.74273993
147MP0005266_abnormal_metabolism0.73690836
148MP0003186_abnormal_redox_activity0.72888871
149MP0005330_cardiomyopathy0.72407071
150MP0008058_abnormal_DNA_repair0.71947094
151MP0004036_abnormal_muscle_relaxation0.70160844
152MP0001915_intracranial_hemorrhage0.69831841
153MP0004185_abnormal_adipocyte_glucose0.69542210
154MP0000432_abnormal_head_morphology0.69155206
155MP0001664_abnormal_digestion0.69118168
156* MP0003755_abnormal_palate_morphology0.68897792
157MP0002116_abnormal_craniofacial_bone0.68341549
158MP0002877_abnormal_melanocyte_morpholog0.68239166
159MP0005164_abnormal_response_to0.67860225
160MP0005501_abnormal_skin_physiology0.67476344
161MP0000759_abnormal_skeletal_muscle0.67004634
162MP0005666_abnormal_adipose_tissue0.66698647
163MP0002876_abnormal_thyroid_physiology0.66323017
164MP0000490_abnormal_crypts_of0.65850761
165MP0002160_abnormal_reproductive_system0.65636433
166MP0004134_abnormal_chest_morphology0.64988865
167MP0002114_abnormal_axial_skeleton0.64099908

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.45356682
2Premature rupture of membranes (HP:0001788)5.24194513
3Hyperglycinuria (HP:0003108)4.47932089
4Aortic dissection (HP:0002647)3.97808191
5Hyperglycinemia (HP:0002154)3.67092053
6Abnormality of glycine metabolism (HP:0010895)3.52674740
7Abnormality of serine family amino acid metabolism (HP:0010894)3.52674740
8Cervical subluxation (HP:0003308)3.47724390
9Follicular hyperkeratosis (HP:0007502)3.39825504
10Abnormality of carpal bone ossification (HP:0006257)3.37736597
11Vascular tortuosity (HP:0004948)3.35972943
12Shallow orbits (HP:0000586)3.31742636
13Ependymoma (HP:0002888)3.29974652
14Malnutrition (HP:0004395)3.12077217
15Type 1 muscle fiber predominance (HP:0003803)3.08683656
16Neonatal short-limb short stature (HP:0008921)3.03980414
17Arterial tortuosity (HP:0005116)3.00137813
18* Shawl scrotum (HP:0000049)2.96208921
19Soft skin (HP:0000977)2.95987750
20Abnormal ossification of hand bones (HP:0005921)2.94124126
21Wormian bones (HP:0002645)2.93952256
22Hypobetalipoproteinemia (HP:0003563)2.91617343
23Spinal rigidity (HP:0003306)2.90289584
24Impulsivity (HP:0100710)2.87422759
25Abnormality of monocarboxylic acid metabolism (HP:0010996)2.87108142
26Overgrowth (HP:0001548)2.77111009
27Bladder diverticulum (HP:0000015)2.75717621
28Atrophic scars (HP:0001075)2.74269895
29Ileus (HP:0002595)2.73959291
30Abnormal hand bone ossification (HP:0010660)2.72308534
31Intrahepatic cholestasis (HP:0001406)2.70942106
32Elbow flexion contracture (HP:0002987)2.70185632
33Fragile skin (HP:0001030)2.68721374
34Blue sclerae (HP:0000592)2.68210262
35Patellar aplasia (HP:0006443)2.61380075
36Abnormal tarsal ossification (HP:0008369)2.58314447
37Aplasia/Hypoplasia of the patella (HP:0006498)2.54202155
38Abnormality of the labia minora (HP:0012880)2.52962167
39Vertebral compression fractures (HP:0002953)2.52663584
40Broad metatarsal (HP:0001783)2.50099861
41Multiple enchondromatosis (HP:0005701)2.49475410
42Mildly elevated creatine phosphokinase (HP:0008180)2.46624842
43Alopecia of scalp (HP:0002293)2.46590600
44* Aplasia/hypoplasia of the humerus (HP:0006507)2.45118120
45Aneurysm (HP:0002617)2.39300869
46Premature ovarian failure (HP:0008209)2.37098737
47Flat acetabular roof (HP:0003180)2.36612066
48Biconcave vertebral bodies (HP:0004586)2.36156316
49Testicular atrophy (HP:0000029)2.32213751
50Abnormality of dentin (HP:0010299)2.31363954
51Muscle fibrillation (HP:0010546)2.30632078
52Wide anterior fontanel (HP:0000260)2.30065214
53Abnormality of the astrocytes (HP:0100707)2.28876340
54Astrocytoma (HP:0009592)2.28876340
55Carpal bone hypoplasia (HP:0001498)2.28801165
56Abnormal hemoglobin (HP:0011902)2.28024484
57Rectal fistula (HP:0100590)2.27101274
58Rectovaginal fistula (HP:0000143)2.27101274
59Selective tooth agenesis (HP:0001592)2.26999683
60Joint laxity (HP:0001388)2.25626368
61Abnormality of sulfur amino acid metabolism (HP:0004339)2.25400187
62Mitral valve prolapse (HP:0001634)2.25325793
63Polycythemia (HP:0001901)2.25076878
64Rib fusion (HP:0000902)2.24551211
65Advanced eruption of teeth (HP:0006288)2.24100301
66* Short humerus (HP:0005792)2.23756804
67Abnormality of glutamine family amino acid metabolism (HP:0010902)2.22161240
68* Absent radius (HP:0003974)2.21728013
69Osteolytic defects of the hand bones (HP:0009699)2.20748797
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.20748797
71Cerebral aneurysm (HP:0004944)2.20653218
72Cardiovascular calcification (HP:0011915)2.20409813
73Abnormality of the acetabulum (HP:0003170)2.19951783
74Coronal craniosynostosis (HP:0004440)2.19513812
75Hypolipoproteinemia (HP:0010981)2.18483609
76Hypochromic microcytic anemia (HP:0004840)2.17751496
77Right ventricular cardiomyopathy (HP:0011663)2.16711844
78Syringomyelia (HP:0003396)2.15874064
79Spinal cord lesions (HP:0100561)2.15874064
80Progressive muscle weakness (HP:0003323)2.15788219
81Fat malabsorption (HP:0002630)2.15133762
82Vaginal fistula (HP:0004320)2.14414494
83Mitral stenosis (HP:0001718)2.13667904
84Esophageal varix (HP:0002040)2.13505834
85Disproportionate tall stature (HP:0001519)2.13406181
86Ureteral duplication (HP:0000073)2.13321516
87Trismus (HP:0000211)2.13214213
88Intestinal fistula (HP:0100819)2.12950451
89Natal tooth (HP:0000695)2.11869033
90Tongue fasciculations (HP:0001308)2.11042892
91Partial duplication of the phalanx of hand (HP:0009999)2.10934802
92* Breast hypoplasia (HP:0003187)2.09535347
93Adactyly (HP:0009776)2.09052884
94Glioma (HP:0009733)2.08658125
95Slender build (HP:0001533)2.07142132
96Hypoventilation (HP:0002791)2.06928389
97Aortic regurgitation (HP:0001659)2.06866260
98Hyperextensible skin (HP:0000974)2.05892653
99Abnormal delivery (HP:0001787)2.03816367
100Short 1st metacarpal (HP:0010034)2.03797335
101Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.03797335
102Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03701925
103Abnormality of the umbilical cord (HP:0010881)2.03175762
104Ankle contracture (HP:0006466)2.03174199
105Abnormal foot bone ossification (HP:0010675)2.02722788
106Abnormality of the phalanges of the hallux (HP:0010057)2.02587368
107Abnormality of pyrimidine metabolism (HP:0004353)2.01006492
108Fused cervical vertebrae (HP:0002949)1.99675659
109Hyperammonemia (HP:0001987)1.99653230
110* Absent forearm bone (HP:0003953)1.99600260
111* Aplasia involving forearm bones (HP:0009822)1.99600260
112Orthostatic hypotension (HP:0001278)1.98982866
113Genu recurvatum (HP:0002816)1.98864551
114Abnormal cartilage morphology (HP:0002763)1.97533510
115Biliary tract neoplasm (HP:0100574)1.97194958
116Increased variability in muscle fiber diameter (HP:0003557)1.96314226
117Dilatation of the ascending aorta (HP:0005111)1.95859367
118Short nail (HP:0001799)1.94363692
119Facial hemangioma (HP:0000329)1.94063971
120Gout (HP:0001997)1.93290932
121Difficulty climbing stairs (HP:0003551)1.93009250
122Obstructive sleep apnea (HP:0002870)1.92329190
123Rhabdomyosarcoma (HP:0002859)1.92271032
124Increased connective tissue (HP:0009025)1.92245696
125Abnormality of abdominal situs (HP:0011620)1.91967632
126Abdominal situs inversus (HP:0003363)1.91967632
127Ulnar bowing (HP:0003031)1.91835890
128Abnormality of the distal phalanges of the toes (HP:0010182)1.91571423
129Lip pit (HP:0100267)1.91356532
130Abnormality of the 1st metacarpal (HP:0010009)1.90925259
131Knee flexion contracture (HP:0006380)1.90414234
132Mitral regurgitation (HP:0001653)1.90055237
133Birth length less than 3rd percentile (HP:0003561)1.89746554
134Abnormality of proline metabolism (HP:0010907)1.89442939
135Hydroxyprolinuria (HP:0003080)1.89442939
136Congenital, generalized hypertrichosis (HP:0004540)1.87198811
137Cupped ribs (HP:0000887)1.86864276
138Pseudobulbar signs (HP:0002200)1.86785063
139Morphological abnormality of the middle ear (HP:0008609)1.86043721
140Single umbilical artery (HP:0001195)1.84913753
141Abnormality of the fetal cardiovascular system (HP:0010948)1.84913753
142Abnormal umbilical cord blood vessels (HP:0011403)1.84913753
143Broad face (HP:0000283)1.84783567
144Renal duplication (HP:0000075)1.84577306
145Long toe (HP:0010511)1.84490488
146Renal salt wasting (HP:0000127)1.84226337
147Supernumerary spleens (HP:0009799)1.81474265
148Xanthomatosis (HP:0000991)1.80593668
149Vascular calcification (HP:0004934)1.80308697
150Colon cancer (HP:0003003)1.78769230
151Spondylolisthesis (HP:0003302)1.78551045
152Coxa vara (HP:0002812)1.77944784
153Narrow palate (HP:0000189)1.77496599
154Hypoplasia of the iris (HP:0007676)1.77281375
155Abnormality of the intrinsic pathway (HP:0010989)1.77183306
156Camptodactyly of toe (HP:0001836)1.76361308
157Persistence of primary teeth (HP:0006335)1.76328649
158Flared iliac wings (HP:0002869)1.76296466
159Atrioventricular block (HP:0001678)1.76296196
160Aplasia/Hypoplasia of the hallux (HP:0008362)1.76119695
161Bowel diverticulosis (HP:0005222)1.76044281
162Secondary amenorrhea (HP:0000869)1.75886664
163Gastrointestinal dysmotility (HP:0002579)1.75459169
164Pustule (HP:0200039)1.74754973
165Complement deficiency (HP:0004431)1.73835084
166Abnormality of complement system (HP:0005339)1.73103037
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.72587327
168Achilles tendon contracture (HP:0001771)1.72545724
169Rectal prolapse (HP:0002035)1.72335891
170Abnormality of the lower motor neuron (HP:0002366)1.71981745
171Spastic diplegia (HP:0001264)1.71769877
172* Sparse lateral eyebrow (HP:0005338)1.71618746
173Thin bony cortex (HP:0002753)1.70590872
174Bowed forearm bones (HP:0003956)1.70425291
175Bowing of the arm (HP:0006488)1.70425291
176Abnormality of the 2nd finger (HP:0004100)1.70205994
177Abnormality of the salivary glands (HP:0010286)1.70125859
178Abnormality of the Achilles tendon (HP:0005109)1.69973280
179Long eyelashes (HP:0000527)1.69701923
180Absent toe (HP:0010760)1.69303540
181Rough bone trabeculation (HP:0100670)1.69088909
182Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.68824440
183Peritonitis (HP:0002586)1.68554217
184Aortic aneurysm (HP:0004942)1.68407804
185Asymmetry of the thorax (HP:0001555)1.68361916
186Deep venous thrombosis (HP:0002625)1.66979002
187Abnormality of serum amino acid levels (HP:0003112)1.66324830
188Myopathic facies (HP:0002058)1.66008674
189Hypoalphalipoproteinemia (HP:0003233)1.65719342
190Areflexia of lower limbs (HP:0002522)1.65185882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.16180254
2TRIB33.72447590
3CDK122.98537212
4BUB12.97991838
5WEE12.96297103
6LATS12.81106950
7PRKD32.66938262
8LATS22.54209431
9TTK2.24840725
10PDK22.22542062
11BCKDK2.19714708
12PRKD22.16242848
13ERN12.09843412
14RPS6KB22.07036886
15CAMK1D1.95073170
16STK38L1.90669581
17TIE11.89621087
18CDK71.87683563
19TSSK61.84727334
20NEK11.83631999
21DDR21.79501837
22NEK91.72916800
23NEK21.70889556
24CAMK1G1.70762045
25ICK1.67961288
26PKN21.63101217
27MST41.61896468
28STK31.59210421
29MYLK1.58758183
30FGFR41.58578665
31STK381.56126153
32MAPKAPK31.54599247
33SMG11.44944686
34PLK11.39166201
35FRK1.35928251
36PDGFRB1.34184353
37KDR1.33417038
38NTRK11.33176885
39MET1.32273677
40ERBB41.32250320
41PLK41.27880578
42BRSK21.26720264
43PRKCI1.23749571
44MTOR1.19296932
45PDGFRA1.19168062
46STK391.15216166
47PAK41.12362220
48PAK21.11269429
49WNK41.11255791
50ZAK1.08986006
51PINK11.08412731
52MAP3K81.07104909
53FER1.05717227
54MAP2K21.05386974
55STK101.04406866
56AURKB1.04390482
57TESK21.03617988
58DMPK0.99994029
59TRPM70.99632408
60CHEK20.98692971
61TAOK30.96115812
62EIF2AK10.93923248
63DYRK30.93897730
64PDK30.93817460
65PDK40.93817460
66SRPK10.89764439
67BMX0.88905628
68SIK10.86587019
69TTN0.85135619
70PIM20.84237313
71EPHB20.82402022
72PNCK0.81940323
73RPS6KA20.80611368
74FGFR30.80026356
75GRK10.79576990
76PTK20.78088483
77AURKA0.77163635
78MATK0.77090720
79AKT20.73465366
80PLK30.72040014
81PTK60.71455858
82PRKAA20.70727907
83PAK10.70405594
84TGFBR10.69916334
85PDPK10.69701796
86EEF2K0.69674786
87CDK40.69363264
88EPHB10.67901749
89MAP3K110.66764971
90PRKD10.64973087
91TESK10.64936272
92RIPK10.64921771
93MARK20.64670936
94CHEK10.64537125
95FLT30.63187801
96GSK3A0.61408086
97TYRO30.60934633
98RET0.60230522
99CDK60.57251088
100PIM10.56534893
101CSNK1E0.56063767
102PIK3CA0.55832075
103MELK0.55823950
104CDK20.55700357
105PRKG20.55606171
106PIK3CG0.54540588
107MAP2K10.53355415
108SCYL20.53201797
109ACVR1B0.52942979
110STK40.52762012
111TGFBR20.52332412
112MAP3K30.52229590
113PRKAA10.51451098
114RPS6KC10.51332219
115RPS6KL10.51332219
116WNK10.51032535
117BRD40.50153811
118NUAK10.49225132
119ILK0.48548394
120MAP3K60.48543623
121SGK30.47430164
122ROCK10.47379618
123NME20.46999195
124ABL20.46114259
125ATR0.45305154
126CDK80.44063524
127LMTK20.43754538
128CDC70.42516574
129CHUK0.41108206
130CDK90.40375899
131ERBB20.40287445
132IRAK30.40095121
133LRRK20.39936978
134CSNK2A20.39881212
135HIPK20.39836341
136CDC42BPA0.39656464
137ALK0.39613052
138CSNK2A10.38660751
139RPS6KA60.38476532
140JAK10.38226159
141ATM0.38183633
142FGFR10.37625853
143PAK30.37442086
144DYRK1B0.36436266
145MAPK110.35718291
146TLK10.35033506
147MAP3K70.34995286
148MAPK70.34982448
149MAP3K100.34677751
150MAPK10.34520317
151MST1R0.34475594
152LIMK10.32589234
153PRKCH0.31287186
154MAP3K20.29496279
155DAPK30.26345278

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.02427442
2ECM-receptor interaction_Homo sapiens_hsa045122.77699357
3Folate biosynthesis_Homo sapiens_hsa007902.71368052
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40464217
5Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.28041128
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.20445002
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.15862115
8Focal adhesion_Homo sapiens_hsa045102.13301333
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06395603
10Vitamin digestion and absorption_Homo sapiens_hsa049772.05078577
11Arginine biosynthesis_Homo sapiens_hsa002202.04549374
12Fat digestion and absorption_Homo sapiens_hsa049752.04531836
13Renin-angiotensin system_Homo sapiens_hsa046141.88433740
14RNA transport_Homo sapiens_hsa030131.84327285
15Nitrogen metabolism_Homo sapiens_hsa009101.81707556
16One carbon pool by folate_Homo sapiens_hsa006701.78956706
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.70852791
18Biosynthesis of amino acids_Homo sapiens_hsa012301.69034650
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.65853692
20Fructose and mannose metabolism_Homo sapiens_hsa000511.61504051
21Mismatch repair_Homo sapiens_hsa034301.60915430
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.56689290
23RNA polymerase_Homo sapiens_hsa030201.55207198
24Proteoglycans in cancer_Homo sapiens_hsa052051.54715897
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53789989
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52409248
27Ovarian steroidogenesis_Homo sapiens_hsa049131.51538086
28Selenocompound metabolism_Homo sapiens_hsa004501.48437788
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44580166
30Tryptophan metabolism_Homo sapiens_hsa003801.42481128
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42195909
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.41464964
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40927755
34DNA replication_Homo sapiens_hsa030301.39710429
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.39611950
36Arginine and proline metabolism_Homo sapiens_hsa003301.39095976
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38174742
38Prion diseases_Homo sapiens_hsa050201.34631647
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33525670
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.32863394
41Prostate cancer_Homo sapiens_hsa052151.31269098
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28939767
43Amoebiasis_Homo sapiens_hsa051461.26969577
44Galactose metabolism_Homo sapiens_hsa000521.25896459
45Hippo signaling pathway_Homo sapiens_hsa043901.25066858
46Thyroid hormone synthesis_Homo sapiens_hsa049181.21833873
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20446778
48Adherens junction_Homo sapiens_hsa045201.20358722
49Phenylalanine metabolism_Homo sapiens_hsa003601.20111352
50Carbon metabolism_Homo sapiens_hsa012001.18867828
51Spliceosome_Homo sapiens_hsa030401.18482131
52Cell cycle_Homo sapiens_hsa041101.16624084
53Fatty acid degradation_Homo sapiens_hsa000711.15562671
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14719880
55Sulfur relay system_Homo sapiens_hsa041221.14170860
56Base excision repair_Homo sapiens_hsa034101.13896611
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.13027278
58MicroRNAs in cancer_Homo sapiens_hsa052061.10124831
59Other glycan degradation_Homo sapiens_hsa005111.09913329
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09405804
61Bile secretion_Homo sapiens_hsa049761.09348869
62Tight junction_Homo sapiens_hsa045301.09269102
63Mineral absorption_Homo sapiens_hsa049781.09126748
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05494405
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05348901
66Caffeine metabolism_Homo sapiens_hsa002321.04911285
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04254568
68Ribosome_Homo sapiens_hsa030101.03997684
69Pentose phosphate pathway_Homo sapiens_hsa000301.02919168
70PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99723111
71p53 signaling pathway_Homo sapiens_hsa041150.99014031
72* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97853951
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97285459
74Glutathione metabolism_Homo sapiens_hsa004800.97218763
75Chronic myeloid leukemia_Homo sapiens_hsa052200.96446458
76PPAR signaling pathway_Homo sapiens_hsa033200.95735194
77Insulin resistance_Homo sapiens_hsa049310.94941628
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.94827528
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94084679
80Melanoma_Homo sapiens_hsa052180.93297293
81Pyrimidine metabolism_Homo sapiens_hsa002400.91795171
82AMPK signaling pathway_Homo sapiens_hsa041520.90380586
83TGF-beta signaling pathway_Homo sapiens_hsa043500.89524034
84Dilated cardiomyopathy_Homo sapiens_hsa054140.88310806
85Basal cell carcinoma_Homo sapiens_hsa052170.87469334
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86999153
87Proteasome_Homo sapiens_hsa030500.86557079
88Sulfur metabolism_Homo sapiens_hsa009200.85468554
89Fatty acid metabolism_Homo sapiens_hsa012120.83685604
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83644189
91Starch and sucrose metabolism_Homo sapiens_hsa005000.82735453
92Histidine metabolism_Homo sapiens_hsa003400.82173025
93Nucleotide excision repair_Homo sapiens_hsa034200.81812790
94Lysine degradation_Homo sapiens_hsa003100.79370005
95Complement and coagulation cascades_Homo sapiens_hsa046100.79229097
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.78522374
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78473350
98Endometrial cancer_Homo sapiens_hsa052130.78286434
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77518760
100beta-Alanine metabolism_Homo sapiens_hsa004100.77367917
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77026688
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.76171047
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75689980
104Pathways in cancer_Homo sapiens_hsa052000.75457841
105Retinol metabolism_Homo sapiens_hsa008300.75329917
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74474604
107Insulin signaling pathway_Homo sapiens_hsa049100.73204627
108Chemical carcinogenesis_Homo sapiens_hsa052040.73081701
109Homologous recombination_Homo sapiens_hsa034400.72054247
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71559354
111Glucagon signaling pathway_Homo sapiens_hsa049220.71048714
112Protein digestion and absorption_Homo sapiens_hsa049740.70835089
113mRNA surveillance pathway_Homo sapiens_hsa030150.69889942
114Melanogenesis_Homo sapiens_hsa049160.69187882
115Fanconi anemia pathway_Homo sapiens_hsa034600.68478449
116Hedgehog signaling pathway_Homo sapiens_hsa043400.68377580
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67710206
118Glioma_Homo sapiens_hsa052140.66067407
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65838370
120Propanoate metabolism_Homo sapiens_hsa006400.65781511
121Glycerolipid metabolism_Homo sapiens_hsa005610.65112261
122Vibrio cholerae infection_Homo sapiens_hsa051100.63300040
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63171952
124Fatty acid biosynthesis_Homo sapiens_hsa000610.62658331
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62443225
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60941198
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.60670890
128FoxO signaling pathway_Homo sapiens_hsa040680.59944894
129Estrogen signaling pathway_Homo sapiens_hsa049150.59495888
130Prolactin signaling pathway_Homo sapiens_hsa049170.59397746
131Wnt signaling pathway_Homo sapiens_hsa043100.59257819
132Bladder cancer_Homo sapiens_hsa052190.58513371
133Small cell lung cancer_Homo sapiens_hsa052220.57713823
134Tyrosine metabolism_Homo sapiens_hsa003500.57407659
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57053278
136ABC transporters_Homo sapiens_hsa020100.56127508
137Choline metabolism in cancer_Homo sapiens_hsa052310.55961356
138Regulation of autophagy_Homo sapiens_hsa041400.55518917
139ErbB signaling pathway_Homo sapiens_hsa040120.55144429
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.52589487
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.52276367
142Pyruvate metabolism_Homo sapiens_hsa006200.52153993
143mTOR signaling pathway_Homo sapiens_hsa041500.50883958
144N-Glycan biosynthesis_Homo sapiens_hsa005100.50612479
145Gap junction_Homo sapiens_hsa045400.50495687
146GnRH signaling pathway_Homo sapiens_hsa049120.50455334
147Thyroid cancer_Homo sapiens_hsa052160.49522495
148Metabolic pathways_Homo sapiens_hsa011000.48361678
149Renal cell carcinoma_Homo sapiens_hsa052110.48207088
150Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48175114
151Purine metabolism_Homo sapiens_hsa002300.47578086
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46525093
153Peroxisome_Homo sapiens_hsa041460.45097923
154Notch signaling pathway_Homo sapiens_hsa043300.44744250
155Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44149128
156Basal transcription factors_Homo sapiens_hsa030220.43547077

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