TBX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.37857586
2notochord development (GO:0030903)4.27854132
3DNA strand renaturation (GO:0000733)4.23765488
4paraxial mesoderm development (GO:0048339)4.23514397
5regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.16780093
6mitotic metaphase plate congression (GO:0007080)4.16679665
7regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.09538322
8mitotic chromosome condensation (GO:0007076)4.03649790
9behavioral response to nicotine (GO:0035095)4.01585868
10head development (GO:0060322)4.00623961
11adaptation of signaling pathway (GO:0023058)3.91972878
12negative regulation of hormone biosynthetic process (GO:0032353)3.91230565
13negative regulation of hormone metabolic process (GO:0032351)3.91230565
14regulation of sister chromatid cohesion (GO:0007063)3.89883216
15positive regulation of DNA-dependent DNA replication (GO:2000105)3.89787365
16regulation of transforming growth factor beta2 production (GO:0032909)3.86207046
17regulation of meiosis (GO:0040020)3.83716015
18histone H2A monoubiquitination (GO:0035518)3.82356451
19response to pheromone (GO:0019236)3.81304938
20peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.79969323
21DNA deamination (GO:0045006)3.76178673
22mitotic sister chromatid segregation (GO:0000070)3.74109877
23type B pancreatic cell development (GO:0003323)3.73010953
24antigen processing and presentation via MHC class Ib (GO:0002475)3.69312664
25metaphase plate congression (GO:0051310)3.68520289
26DNA damage induced protein phosphorylation (GO:0006975)3.68069901
27nephron epithelium morphogenesis (GO:0072088)3.56696306
28nephron tubule morphogenesis (GO:0072078)3.56696306
29mitotic sister chromatid cohesion (GO:0007064)3.52882395
30female gamete generation (GO:0007292)3.50858802
31DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.49145193
32respiratory tube development (GO:0030323)3.47650922
33L-fucose catabolic process (GO:0042355)3.46011653
34fucose catabolic process (GO:0019317)3.46011653
35L-fucose metabolic process (GO:0042354)3.46011653
36regulation of exit from mitosis (GO:0007096)3.45959062
37negative regulation of smooth muscle cell differentiation (GO:0051151)3.45383313
38meiotic chromosome segregation (GO:0045132)3.45147450
39protein polyglutamylation (GO:0018095)3.44878285
40pericardium development (GO:0060039)3.44112590
41negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.43930727
42negative regulation of alcohol biosynthetic process (GO:1902931)3.41492152
43platelet dense granule organization (GO:0060155)3.41127435
44cell differentiation involved in metanephros development (GO:0072202)3.40737046
45cartilage morphogenesis (GO:0060536)3.40152439
46negative regulation of systemic arterial blood pressure (GO:0003085)3.38638176
47monoubiquitinated protein deubiquitination (GO:0035520)3.38340873
48positive regulation of endothelial cell differentiation (GO:0045603)3.32414461
49positive regulation of gastrulation (GO:2000543)3.32319506
50establishment of chromosome localization (GO:0051303)3.30673626
51glycine transport (GO:0015816)3.30130929
52artery development (GO:0060840)3.29724947
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.28321837
54negative regulation of meiosis (GO:0045835)3.28102088
55regulation of cardioblast differentiation (GO:0051890)3.23571367
56sister chromatid segregation (GO:0000819)3.23501200
57DNA damage response, signal transduction resulting in transcription (GO:0042772)3.22289719
58meiotic cell cycle (GO:0051321)3.16935326
59negative regulation of complement activation (GO:0045916)3.16167806
60indolalkylamine metabolic process (GO:0006586)3.14826834
61regulation of glucocorticoid metabolic process (GO:0031943)3.10937123
62regulation of smooth muscle cell differentiation (GO:0051150)3.09982166
63chemical homeostasis within a tissue (GO:0048875)3.09378268
64wound healing, spreading of cells (GO:0044319)3.08200962
65surfactant homeostasis (GO:0043129)3.08153272
66positive regulation of antigen processing and presentation (GO:0002579)3.07519015
67positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.07479244
68polarized epithelial cell differentiation (GO:0030859)3.07468978
69embryonic digestive tract morphogenesis (GO:0048557)3.02927234
70regulation of endothelial cell differentiation (GO:0045601)3.02222935
71renal tubule morphogenesis (GO:0061333)3.01272777
72positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.00370603
73maturation of 5.8S rRNA (GO:0000460)3.00034583
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99968135
75oocyte maturation (GO:0001556)2.99458635
76regulation of spindle organization (GO:0090224)2.97734092
77regulation of meiotic cell cycle (GO:0051445)2.97727062
78negative regulation of catenin import into nucleus (GO:0035414)2.96582948
79regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.95868272
80myoblast migration (GO:0051451)2.95655313
81lung vasculature development (GO:0060426)2.95088418
82regulation of mononuclear cell migration (GO:0071675)2.91023630
83attachment of spindle microtubules to kinetochore (GO:0008608)2.90842221
84male meiosis (GO:0007140)2.90465023
85smooth muscle tissue development (GO:0048745)2.89812283
86protein localization to kinetochore (GO:0034501)2.88851239
87regulation of steroid hormone biosynthetic process (GO:0090030)2.88255352
88DNA methylation involved in gamete generation (GO:0043046)2.87575438
89blood vessel maturation (GO:0001955)2.87266209
90detection of light stimulus involved in sensory perception (GO:0050962)2.87215901
91detection of light stimulus involved in visual perception (GO:0050908)2.87215901
92glandular epithelial cell development (GO:0002068)2.85759334
93histone H2A ubiquitination (GO:0033522)2.85625597
94sperm motility (GO:0030317)2.85476732
95spindle checkpoint (GO:0031577)2.84613940
96regulation of mitotic spindle organization (GO:0060236)2.83928227
97kidney morphogenesis (GO:0060993)2.82256204
98regulation of hippo signaling (GO:0035330)2.81640156
99male genitalia development (GO:0030539)2.81450463
100regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.81426049
101epithelial cilium movement (GO:0003351)2.80500375
102phosphate ion homeostasis (GO:0055062)2.80465255
103trivalent inorganic anion homeostasis (GO:0072506)2.80465255
104protein localization to chromosome, centromeric region (GO:0071459)2.80143342
105chromosome segregation (GO:0007059)2.79338308
106regulation of meiosis I (GO:0060631)2.78877681
107kynurenine metabolic process (GO:0070189)2.78856782
108axoneme assembly (GO:0035082)2.78840709
109regulation of chromosome segregation (GO:0051983)2.78734834
110cornea development in camera-type eye (GO:0061303)2.78204387
111establishment of apical/basal cell polarity (GO:0035089)2.78066389
112cell proliferation in forebrain (GO:0021846)2.77755007
113mitotic nuclear envelope disassembly (GO:0007077)2.75819196
114regulation of retinoic acid receptor signaling pathway (GO:0048385)2.74552034
115regulation of female gonad development (GO:2000194)2.73558623
116inner ear receptor stereocilium organization (GO:0060122)2.73444966
117proteasome assembly (GO:0043248)2.73142962
118female gonad development (GO:0008585)2.73012483
119mesenchymal cell differentiation involved in kidney development (GO:0072161)2.72079535
120mesenchymal cell differentiation involved in renal system development (GO:2001012)2.72079535
121indole-containing compound catabolic process (GO:0042436)2.71814568
122indolalkylamine catabolic process (GO:0046218)2.71814568
123tryptophan catabolic process (GO:0006569)2.71814568
124tachykinin receptor signaling pathway (GO:0007217)2.71597387
125endocardial cushion development (GO:0003197)2.70404282
126negative regulation of mast cell activation (GO:0033004)2.70057011
127negative regulation of protein activation cascade (GO:2000258)2.69640471
128regulation of keratinocyte proliferation (GO:0010837)2.69470727
129lymphangiogenesis (GO:0001946)2.68224989
130protein K6-linked ubiquitination (GO:0085020)2.67594931
131sister chromatid cohesion (GO:0007062)2.67440494
132negative regulation of multicellular organism growth (GO:0040015)2.67031960
133wound healing, spreading of epidermal cells (GO:0035313)2.66291738
134negative regulation of keratinocyte proliferation (GO:0010839)2.65406401
135gene silencing by RNA (GO:0031047)2.65154906
136regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.64835524
137craniofacial suture morphogenesis (GO:0097094)2.64314907
138negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.64139942
139somatic stem cell division (GO:0048103)2.63857568
140fibroblast migration (GO:0010761)2.63136742
141mitotic spindle checkpoint (GO:0071174)2.62544767
142mesodermal cell differentiation (GO:0048333)2.62453166
143dopamine transport (GO:0015872)2.62165497
144pattern specification involved in kidney development (GO:0061004)2.61705031
145nuclear envelope disassembly (GO:0051081)2.60265251
146membrane disassembly (GO:0030397)2.60265251
147tryptophan metabolic process (GO:0006568)2.60201424
148positive regulation of epithelial to mesenchymal transition (GO:0010718)2.60065637
149kinetochore assembly (GO:0051382)2.59303883
150regulation of telomere maintenance via telomerase (GO:0032210)2.58148081
151auditory receptor cell stereocilium organization (GO:0060088)2.57651224
152positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.56506391
153cellular response to nitric oxide (GO:0071732)2.56332540
154neuronal action potential (GO:0019228)2.55908383
155negative regulation of chromosome segregation (GO:0051985)2.54922027
156negative regulation of nuclear division (GO:0051784)2.54836639
157mitotic spindle assembly checkpoint (GO:0007094)2.54821715
158protein localization to chromosome (GO:0034502)2.54783451
159negative regulation of sister chromatid segregation (GO:0033046)2.54061642
160negative regulation of mitotic sister chromatid segregation (GO:0033048)2.54061642
161positive regulation of embryonic development (GO:0040019)2.49996034
162photoreceptor cell maintenance (GO:0045494)2.49205495
163response to BMP (GO:0071772)2.48682862
164cellular response to BMP stimulus (GO:0071773)2.48682862
165segment specification (GO:0007379)2.45892438
166toxin metabolic process (GO:0009404)2.45271150
167retinal ganglion cell axon guidance (GO:0031290)2.44711589
168multicellular organism reproduction (GO:0032504)2.44403167
169reflex (GO:0060004)2.43901183
170cilium organization (GO:0044782)2.43567803
171appendage development (GO:0048736)2.43460811
172limb development (GO:0060173)2.43460811
173gamma-aminobutyric acid transport (GO:0015812)2.41890894
174cilium movement (GO:0003341)2.41161909
175cilium or flagellum-dependent cell motility (GO:0001539)2.36284790
176retinal cone cell development (GO:0046549)2.36239941
177regulation of action potential (GO:0098900)2.36134884
178indole-containing compound metabolic process (GO:0042430)2.35038254
179antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.34897768
180somite rostral/caudal axis specification (GO:0032525)2.33843687
181primary amino compound metabolic process (GO:1901160)2.33609642
182regulation of vasculogenesis (GO:2001212)2.33579512
183regulation of memory T cell differentiation (GO:0043380)2.33535641
184regulation of non-canonical Wnt signaling pathway (GO:2000050)2.33397640
185cilium assembly (GO:0042384)2.32198427
186sulfation (GO:0051923)2.30751188
187regulation of cilium movement (GO:0003352)2.29920168
188glomerulus development (GO:0032835)2.29188241
189one-carbon compound transport (GO:0019755)2.27070659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.08904962
2E2F7_22180533_ChIP-Seq_HELA_Human4.73148539
3SMAD_19615063_ChIP-ChIP_OVARY_Human4.16474192
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.86757567
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.75329488
6ZNF274_21170338_ChIP-Seq_K562_Hela3.33385969
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.18089384
8VDR_22108803_ChIP-Seq_LS180_Human3.06658667
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.93650843
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.82991810
11EZH2_22144423_ChIP-Seq_EOC_Human2.65827953
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.61911888
13AR_21909140_ChIP-Seq_LNCAP_Human2.58492169
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57264894
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40335451
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.31358028
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25282868
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18515511
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08364075
20HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.03202734
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00840818
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.92564643
23P300_19829295_ChIP-Seq_ESCs_Human1.90633587
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90344054
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.86504574
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81058726
27CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.78540817
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.74618086
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.71871778
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68947784
31ISL1_27105846_Chip-Seq_CPCs_Mouse1.68307276
32* EED_16625203_ChIP-ChIP_MESCs_Mouse1.67010179
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65510582
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64492443
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64023597
36* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63628197
37FUS_26573619_Chip-Seq_HEK293_Human1.62347899
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.59019683
39CJUN_26792858_Chip-Seq_BT549_Human1.58314981
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56225643
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53273149
42TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.52661261
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51728579
44EWS_26573619_Chip-Seq_HEK293_Human1.51620567
45TAF15_26573619_Chip-Seq_HEK293_Human1.50983204
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50284878
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.49516469
48* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.49071728
49BRD4_25478319_ChIP-Seq_HGPS_Human1.48149011
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47352719
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.45007676
52* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44601654
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43231308
54* EZH2_27304074_Chip-Seq_ESCs_Mouse1.42863176
55ER_23166858_ChIP-Seq_MCF-7_Human1.41012179
56* RNF2_27304074_Chip-Seq_NSC_Mouse1.40105224
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39898337
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39616507
59CBP_20019798_ChIP-Seq_JUKART_Human1.39197927
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39197927
61AR_25329375_ChIP-Seq_VCAP_Human1.38648552
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.35522168
63TCF4_22108803_ChIP-Seq_LS180_Human1.35455517
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35099862
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.34486164
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.33999472
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33283622
68* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32787947
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.31852978
70AR_21572438_ChIP-Seq_LNCaP_Human1.31556304
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.30274817
72BCAT_22108803_ChIP-Seq_LS180_Human1.29760838
73* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29023616
74* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27746532
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27265666
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26614350
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26136508
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25411865
79IRF1_19129219_ChIP-ChIP_H3396_Human1.25106451
80ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25082132
81TCF3_18692474_ChIP-Seq_MESCs_Mouse1.25069846
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24969922
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24921592
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24921592
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.24529925
86TP53_22573176_ChIP-Seq_HFKS_Human1.24266533
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.24107989
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22229104
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21934798
90RUNX2_22187159_ChIP-Seq_PCA_Human1.21676813
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21280496
92* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.20918397
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20548760
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20454511
95* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20132980
96NANOG_19829295_ChIP-Seq_ESCs_Human1.19928458
97SOX2_19829295_ChIP-Seq_ESCs_Human1.19928458
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19714353
99* EZH2_27294783_Chip-Seq_ESCs_Mouse1.18902422
100* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18569859
101* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18241899
102SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18122526
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18057329
104* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16973372
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16769522
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16722082
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.16539605
108FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16539605
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16427398
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16168264
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15778239
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15227837
113GBX2_23144817_ChIP-Seq_PC3_Human1.13879148
114* RNF2_27304074_Chip-Seq_ESCs_Mouse1.13834543
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13712990
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13494113
117GATA3_21878914_ChIP-Seq_MCF-7_Human1.12230806
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12138450
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11142415
120* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10990838
121* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10794126
122FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10596136
123STAT3_23295773_ChIP-Seq_U87_Human1.09783407
124KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08482864
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.07497774
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06846974
127* CBX2_27304074_Chip-Seq_ESCs_Mouse1.06655709
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06115702
129IGF1R_20145208_ChIP-Seq_DFB_Human1.05217431
130* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04909587
131SMAD4_21741376_ChIP-Seq_HESCs_Human1.04788404
132TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04384480
133P53_22387025_ChIP-Seq_ESCs_Mouse1.04056365
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.02766850
135* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02524043
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01973775
137* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01894704
138TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01815587
139HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01802148
140BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01669390
141* FLI1_21867929_ChIP-Seq_TH2_Mouse1.01573175
142ARNT_22903824_ChIP-Seq_MCF-7_Human1.00277911
143NCOR_22424771_ChIP-Seq_293T_Human0.99977576
144CDX2_22108803_ChIP-Seq_LS180_Human0.99622928
145* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98313027
146PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97545258
147GF1B_26923725_Chip-Seq_HPCs_Mouse0.97224304
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96126320
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95568464
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.94539820
151CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92203684
152YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90084229
153* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89381012
154NANOG_21062744_ChIP-ChIP_HESCs_Human0.88956584
155TBL1_22424771_ChIP-Seq_293T_Human0.88596509
156TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87552418
157SMAD4_21799915_ChIP-Seq_A2780_Human0.86482540
158VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85985826
159NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.83807816
160NFYA_21822215_ChIP-Seq_K562_Human0.83736575
161CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83680632
162LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83309200
163STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82615584
164ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81078784
165SOX2_16153702_ChIP-ChIP_HESCs_Human0.80443777
166* TCF4_23295773_ChIP-Seq_U87_Human0.80438998
167NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80156693

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.46208909
2MP0002249_abnormal_larynx_morphology2.62161778
3MP0003878_abnormal_ear_physiology2.60216716
4MP0005377_hearing/vestibular/ear_phenot2.60216716
5MP0008438_abnormal_cutaneous_collagen2.59776315
6MP0003718_maternal_effect2.56468923
7MP0010368_abnormal_lymphatic_system2.48788395
8MP0005171_absent_coat_pigmentation2.46787152
9MP0005451_abnormal_body_composition2.46553587
10MP0003123_paternal_imprinting2.36694471
11MP0003121_genomic_imprinting2.32096025
12MP0001986_abnormal_taste_sensitivity2.31966433
13MP0005257_abnormal_intraocular_pressure2.28862895
14MP0005408_hypopigmentation2.28341300
15MP0003705_abnormal_hypodermis_morpholog2.23335187
16MP0001958_emphysema2.17719115
17MP0000566_synostosis2.12946102
18MP0003195_calcinosis2.12315382
19* MP0003937_abnormal_limbs/digits/tail_de2.11345204
20MP0010094_abnormal_chromosome_stability2.04245567
21MP0003136_yellow_coat_color2.04120646
22MP0003693_abnormal_embryo_hatching2.04011506
23MP0002138_abnormal_hepatobiliary_system1.98048963
24MP0003385_abnormal_body_wall1.92415529
25MP0005551_abnormal_eye_electrophysiolog1.91235758
26MP0004782_abnormal_surfactant_physiolog1.88230523
27MP0010030_abnormal_orbit_morphology1.86674964
28MP0005503_abnormal_tendon_morphology1.85091679
29MP0001542_abnormal_bone_strength1.84115459
30MP0006054_spinal_hemorrhage1.83063564
31MP0003077_abnormal_cell_cycle1.81532551
32MP0003111_abnormal_nucleus_morphology1.81390779
33MP0001968_abnormal_touch/_nociception1.80898713
34MP0003787_abnormal_imprinting1.78533505
35MP0003646_muscle_fatigue1.78335721
36MP0000537_abnormal_urethra_morphology1.78307498
37MP0009053_abnormal_anal_canal1.77880778
38MP0003941_abnormal_skin_development1.75103546
39MP0009780_abnormal_chondrocyte_physiolo1.73665337
40MP0000767_abnormal_smooth_muscle1.70806512
41MP0006072_abnormal_retinal_apoptosis1.70636224
42MP0004133_heterotaxia1.69583720
43MP0002653_abnormal_ependyma_morphology1.69234037
44MP0000372_irregular_coat_pigmentation1.67781501
45MP0000013_abnormal_adipose_tissue1.66345970
46MP0005508_abnormal_skeleton_morphology1.66170787
47MP0002282_abnormal_trachea_morphology1.65193749
48MP0003115_abnormal_respiratory_system1.62760348
49* MP0009250_abnormal_appendicular_skeleto1.61968875
50MP0008877_abnormal_DNA_methylation1.61046396
51MP0001501_abnormal_sleep_pattern1.59236391
52MP0001119_abnormal_female_reproductive1.51305254
53MP0004957_abnormal_blastocyst_morpholog1.51124022
54MP0005410_abnormal_fertilization1.48612641
55MP0004272_abnormal_basement_membrane1.48215603
56MP0008872_abnormal_physiological_respon1.48112217
57MP0003755_abnormal_palate_morphology1.47913190
58MP0002938_white_spotting1.47058461
59MP0006292_abnormal_olfactory_placode1.46973028
60MP0004885_abnormal_endolymph1.46388814
61MP0000733_abnormal_muscle_development1.46029949
62MP0005167_abnormal_blood-brain_barrier1.41289908
63MP0002876_abnormal_thyroid_physiology1.40875378
64MP0004142_abnormal_muscle_tone1.40080471
65MP0005253_abnormal_eye_physiology1.40077612
66MP0009384_cardiac_valve_regurgitation1.40037504
67MP0005645_abnormal_hypothalamus_physiol1.39374505
68MP0000534_abnormal_ureter_morphology1.38901968
69MP0003137_abnormal_impulse_conducting1.38847513
70MP0003935_abnormal_craniofacial_develop1.38457164
71MP0005275_abnormal_skin_tensile1.37730110
72MP0008007_abnormal_cellular_replicative1.36884952
73MP0005248_abnormal_Harderian_gland1.36530421
74* MP0002085_abnormal_embryonic_tissue1.35767326
75MP0001440_abnormal_grooming_behavior1.35603723
76MP0001486_abnormal_startle_reflex1.35135405
77MP0000678_abnormal_parathyroid_gland1.35036192
78MP0002932_abnormal_joint_morphology1.33746250
79MP0003315_abnormal_perineum_morphology1.32320837
80MP0005187_abnormal_penis_morphology1.28087470
81MP0003279_aneurysm1.27918420
82MP0002736_abnormal_nociception_after1.27571362
83MP0001835_abnormal_antigen_presentation1.25653171
84MP0001175_abnormal_lung_morphology1.24312922
85MP0000516_abnormal_urinary_system1.22951611
86MP0005367_renal/urinary_system_phenotyp1.22951611
87MP0005395_other_phenotype1.22399933
88MP0003699_abnormal_female_reproductive1.21272732
89MP0002877_abnormal_melanocyte_morpholog1.18158764
90MP0002933_joint_inflammation1.16777389
91MP0003122_maternal_imprinting1.16545442
92* MP0002109_abnormal_limb_morphology1.16014042
93MP0000462_abnormal_digestive_system1.15087174
94MP0003283_abnormal_digestive_organ1.14210135
95MP0006138_congestive_heart_failure1.13338715
96MP0002084_abnormal_developmental_patter1.12540693
97MP0008875_abnormal_xenobiotic_pharmacok1.11785686
98MP0001485_abnormal_pinna_reflex1.11091539
99MP0000026_abnormal_inner_ear1.10800399
100MP0008932_abnormal_embryonic_tissue1.10782970
101MP0009745_abnormal_behavioral_response1.09475355
102MP0005595_abnormal_vascular_smooth1.09408790
103MP0002108_abnormal_muscle_morphology1.09029522
104MP0001672_abnormal_embryogenesis/_devel1.08711427
105MP0005380_embryogenesis_phenotype1.08711427
106MP0002163_abnormal_gland_morphology1.08117242
107MP0000685_abnormal_immune_system1.08032640
108MP0002557_abnormal_social/conspecific_i1.07820298
109MP0003942_abnormal_urinary_system1.07657470
110MP0000631_abnormal_neuroendocrine_gland1.07646504
111MP0002272_abnormal_nervous_system1.07156464
112MP0002177_abnormal_outer_ear1.06198127
113MP0000432_abnormal_head_morphology1.05553463
114MP0002116_abnormal_craniofacial_bone1.05446078
115MP0001293_anophthalmia1.05173313
116MP0002133_abnormal_respiratory_system1.04858538
117MP0005388_respiratory_system_phenotype1.04858538
118MP0002254_reproductive_system_inflammat1.04303439
119MP0000350_abnormal_cell_proliferation1.04139324
120MP0001730_embryonic_growth_arrest1.03637051
121MP0001984_abnormal_olfaction1.02330527
122MP0002132_abnormal_respiratory_system1.02160868
123MP0003091_abnormal_cell_migration1.01492326
124MP0006276_abnormal_autonomic_nervous1.00307277
125* MP0002925_abnormal_cardiovascular_devel1.00085771
126MP0003890_abnormal_embryonic-extraembry0.99602416
127MP0002210_abnormal_sex_determination0.98652156
128MP0002127_abnormal_cardiovascular_syste0.98602460
129MP0009046_muscle_twitch0.95867530
130MP0008057_abnormal_DNA_replication0.95647995
131MP0002114_abnormal_axial_skeleton0.95328040
132MP0003950_abnormal_plasma_membrane0.95214718
133MP0000653_abnormal_sex_gland0.94845471
134MP0001177_atelectasis0.94749924
135MP0000613_abnormal_salivary_gland0.94346418
136MP0004742_abnormal_vestibular_system0.93286542
137MP0001697_abnormal_embryo_size0.93258825
138MP0002295_abnormal_pulmonary_circulatio0.92936658
139MP0008995_early_reproductive_senescence0.92696218
140MP0010386_abnormal_urinary_bladder0.91941249
141MP0009697_abnormal_copulation0.91443327
142MP0001879_abnormal_lymphatic_vessel0.90688463
143MP0004085_abnormal_heartbeat0.90629693
144MP0000049_abnormal_middle_ear0.90591448
145MP0000230_abnormal_systemic_arterial0.89821164
146* MP0002086_abnormal_extraembryonic_tissu0.89705852
147MP0003566_abnormal_cell_adhesion0.89686815
148MP0001502_abnormal_circadian_rhythm0.89298145
149MP0002837_dystrophic_cardiac_calcinosis0.88205086
150MP0000427_abnormal_hair_cycle0.88098711
151MP0002233_abnormal_nose_morphology0.85993390
152MP0003119_abnormal_digestive_system0.85956220
153MP0002638_abnormal_pupillary_reflex0.85941117
154* MP0001614_abnormal_blood_vessel0.84695138
155MP0003984_embryonic_growth_retardation0.83743951
156MP0008775_abnormal_heart_ventricle0.82500600
157* MP0002115_abnormal_skeleton_extremities0.82351413
158MP0003879_abnormal_hair_cell0.80197398
159MP0000470_abnormal_stomach_morphology0.78474409
160MP0002160_abnormal_reproductive_system0.78052465
161MP0005671_abnormal_response_to0.77759980
162MP0004215_abnormal_myocardial_fiber0.77371009
163MP0005084_abnormal_gallbladder_morpholo0.76519084
164MP0002733_abnormal_thermal_nociception0.74898950
165MP0005195_abnormal_posterior_eye0.73571775
166MP0004043_abnormal_pH_regulation0.73444761
167MP0000383_abnormal_hair_follicle0.73274344

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.01455168
2Pancreatic cysts (HP:0001737)3.93448069
3Abnormality of midbrain morphology (HP:0002418)3.81191134
4Molar tooth sign on MRI (HP:0002419)3.81191134
5Nephronophthisis (HP:0000090)3.74295294
6Keratoconus (HP:0000563)3.72584271
7Increased corneal curvature (HP:0100692)3.72584271
8Chronic otitis media (HP:0000389)3.62558936
9Shallow orbits (HP:0000586)3.54720757
10* Shawl scrotum (HP:0000049)3.53336402
11Chromsome breakage (HP:0040012)3.51638517
12Abnormality of the renal medulla (HP:0100957)3.51289645
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47929488
14Pancreatic fibrosis (HP:0100732)3.46665207
15Tubulointerstitial fibrosis (HP:0005576)3.43217022
16Abnormality of the renal cortex (HP:0011035)3.41621376
17Aortic dissection (HP:0002647)3.40824240
18* Midline defect of the nose (HP:0004122)3.33720859
19Tachypnea (HP:0002789)3.28073919
20Ankle contracture (HP:0006466)3.27675877
21True hermaphroditism (HP:0010459)3.24748979
22Papillary thyroid carcinoma (HP:0002895)3.12566973
23Wrist flexion contracture (HP:0001239)3.11788616
24Type II lissencephaly (HP:0007260)3.03414124
25Abnormality of the fetal cardiovascular system (HP:0010948)2.98726228
26Abnormal umbilical cord blood vessels (HP:0011403)2.98726228
27Single umbilical artery (HP:0001195)2.98726228
28Large for gestational age (HP:0001520)2.95803974
29Protrusio acetabuli (HP:0003179)2.93845489
30Tubular atrophy (HP:0000092)2.91192350
31Interstitial pulmonary disease (HP:0006530)2.89240580
32Chronic hepatic failure (HP:0100626)2.79940580
33Abnormality of the phalanges of the hallux (HP:0010057)2.74531505
34Ectopic kidney (HP:0000086)2.73105016
35Aortic aneurysm (HP:0004942)2.70718749
36Congenital, generalized hypertrichosis (HP:0004540)2.69459737
37Follicular hyperkeratosis (HP:0007502)2.63816943
38Tubulointerstitial abnormality (HP:0001969)2.61988866
39Attenuation of retinal blood vessels (HP:0007843)2.60813519
40Short 4th metacarpal (HP:0010044)2.59911132
41Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59911132
42Premature rupture of membranes (HP:0001788)2.59892704
43Abnormality of macular pigmentation (HP:0008002)2.58578915
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.52567235
45* Camptodactyly of toe (HP:0001836)2.50638570
46Arterial tortuosity (HP:0005116)2.50508355
47Short middle phalanx of the 5th finger (HP:0004220)2.46829635
48Submucous cleft hard palate (HP:0000176)2.46619632
49Abnormality of the 4th metacarpal (HP:0010012)2.43889894
50Male infertility (HP:0003251)2.43239879
51Hyperventilation (HP:0002883)2.40901214
52Chronic sinusitis (HP:0011109)2.40655062
53Abnormality of the labia minora (HP:0012880)2.40587888
54Thyroid-stimulating hormone excess (HP:0002925)2.40519219
55Cystic liver disease (HP:0006706)2.39890149
56Short tibia (HP:0005736)2.37670087
57Progressive inability to walk (HP:0002505)2.35636653
58Abnormality of the distal phalanx of the thumb (HP:0009617)2.34528831
59Meckel diverticulum (HP:0002245)2.33708595
60* Patellar aplasia (HP:0006443)2.31897568
61Short hallux (HP:0010109)2.31613911
62Vascular tortuosity (HP:0004948)2.30683487
63Subacute progressive viral hepatitis (HP:0006572)2.30571250
64Elevated erythrocyte sedimentation rate (HP:0003565)2.29554876
65Abnormal rod and cone electroretinograms (HP:0008323)2.28853464
66* Aplasia/Hypoplasia of the patella (HP:0006498)2.28407652
67Aplasia/Hypoplasia of the hallux (HP:0008362)2.27907922
68Type 1 muscle fiber predominance (HP:0003803)2.24183640
69Inability to walk (HP:0002540)2.24101964
70Adrenal hypoplasia (HP:0000835)2.23907286
71Hypoproteinemia (HP:0003075)2.22486865
72Abolished electroretinogram (ERG) (HP:0000550)2.22222011
73Abnormality of the ileum (HP:0001549)2.22090145
74Abnormality of the phalanges of the 2nd finger (HP:0009541)2.18835750
75Abnormal drinking behavior (HP:0030082)2.15639026
76Polydipsia (HP:0001959)2.15639026
77Abnormality of the pulmonary veins (HP:0011718)2.13550526
78Decreased circulating renin level (HP:0003351)2.11507729
79Mesomelia (HP:0003027)2.10725421
80Breast hypoplasia (HP:0003187)2.10655803
81Medial flaring of the eyebrow (HP:0010747)2.09845864
82Broad metatarsal (HP:0001783)2.08398691
83Genu recurvatum (HP:0002816)2.07254662
84Aplasia/Hypoplasia of the fovea (HP:0008060)2.07122399
85Hypoplasia of the fovea (HP:0007750)2.07122399
86Nasal polyposis (HP:0100582)2.04769095
87Short 5th finger (HP:0009237)2.04594692
88Bladder diverticulum (HP:0000015)2.04266226
89Congenital hepatic fibrosis (HP:0002612)2.03667497
90Optic nerve hypoplasia (HP:0000609)2.02748738
91Ulnar bowing (HP:0003031)2.01489490
92Conical tooth (HP:0000698)2.01422775
93Hypothermia (HP:0002045)2.00247158
94Bulbous nose (HP:0000414)1.99445455
95Large eyes (HP:0001090)1.99163400
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98179396
97Capillary hemangiomas (HP:0005306)1.97897148
98Renal duplication (HP:0000075)1.97793613
99Abnormality of the nasal mucosa (HP:0000433)1.97667057
100Alveolar cell carcinoma (HP:0006519)1.97284802
101Synostosis of carpal bones (HP:0005048)1.97114774
102Abnormality of the 2nd finger (HP:0004100)1.97004059
103Complete atrioventricular canal defect (HP:0001674)1.96980903
104Rib fusion (HP:0000902)1.95294793
105Oligodactyly (hands) (HP:0001180)1.94648980
106Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.92528048
107Adactyly (HP:0009776)1.92004198
108Muscle fiber atrophy (HP:0100295)1.91931704
109Abnormality of the pons (HP:0007361)1.91683638
110Sclerocornea (HP:0000647)1.91427740
111Carpal synostosis (HP:0009702)1.91191956
112Respiratory distress (HP:0002098)1.90633620
113Renal cortical cysts (HP:0000803)1.90293400
114Cutaneous finger syndactyly (HP:0010554)1.90050412
115Facial shape deformation (HP:0011334)1.89869855
116Potter facies (HP:0002009)1.89869855
117Pendular nystagmus (HP:0012043)1.89786852
118* Joint contractures involving the joints of the feet (HP:0100492)1.88249512
119* Flexion contracture of toe (HP:0005830)1.88249512
120Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.87683928
121Duodenal stenosis (HP:0100867)1.87476001
122Small intestinal stenosis (HP:0012848)1.87476001
123Occipital encephalocele (HP:0002085)1.86481363
124Spondylolisthesis (HP:0003302)1.86349820
125Facial hemangioma (HP:0000329)1.85654408
126Rectal prolapse (HP:0002035)1.85546083
127Cerebellar dysplasia (HP:0007033)1.85296368
128Aplasia/Hypoplasia of the breasts (HP:0010311)1.85088811
129Aplasia/hypoplasia of the uterus (HP:0008684)1.84755880
130Abnormality of the fovea (HP:0000493)1.84107288
131Mesangial abnormality (HP:0001966)1.83663578
132Abnormality of the middle phalanges of the toes (HP:0010183)1.82388461
133Mitral valve prolapse (HP:0001634)1.81935979
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81485705
135Polyuria (HP:0000103)1.81364471
136Broad thumb (HP:0011304)1.81074210
137Renal dysplasia (HP:0000110)1.79957877
138Breast aplasia (HP:0100783)1.79759980
139Absent eyebrow (HP:0002223)1.79539198
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.78994690
141Trigonocephaly (HP:0000243)1.78981517
142Aplasia/Hypoplasia of the uvula (HP:0010293)1.78810662
143Abnormal biliary tract physiology (HP:0012439)1.78713506
144Bile duct proliferation (HP:0001408)1.78713506
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.78508832
146Absent/shortened dynein arms (HP:0200106)1.78508832
147Decreased central vision (HP:0007663)1.78506427
148Cerebral aneurysm (HP:0004944)1.78226666
149Abnormal lung lobation (HP:0002101)1.78033805
150Stomach cancer (HP:0012126)1.77615775
151Postaxial hand polydactyly (HP:0001162)1.77431550
152Pulmonary artery stenosis (HP:0004415)1.76931819
153Short thumb (HP:0009778)1.76633013
154Lissencephaly (HP:0001339)1.76127116
155Severe visual impairment (HP:0001141)1.76083774
156Soft skin (HP:0000977)1.75768729
157Aortic regurgitation (HP:0001659)1.75435141
158Acute myeloid leukemia (HP:0004808)1.74603029
159Slender build (HP:0001533)1.74306978
160Absent radius (HP:0003974)1.74149687
161Abnormality of the fingertips (HP:0001211)1.73911149
162Embryonal renal neoplasm (HP:0011794)1.73216011
163Distal arthrogryposis (HP:0005684)1.72933846
164Broad-based gait (HP:0002136)1.72753227
165Abnormality of dentin (HP:0010299)1.72348161
166Hypoplasia of the uterus (HP:0000013)1.71913159
167Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.71913049
168Microglossia (HP:0000171)1.71733191
169Broad long bones (HP:0005622)1.71334357
170Broad phalanges of the hand (HP:0009768)1.71149584
171Hypoalbuminemia (HP:0003073)1.70983761
172Abnormal albumin level (HP:0012116)1.70983761
173Abnormality of the ischium (HP:0003174)1.69818810
174Broad phalanx (HP:0006009)1.69104486
175Hypoplasia of the pons (HP:0012110)1.69035269
176Exertional dyspnea (HP:0002875)1.68121016
177Hip contracture (HP:0003273)1.67448137
178Chronic bronchitis (HP:0004469)1.67424506
179Gastrointestinal atresia (HP:0002589)1.67414367
180Preaxial foot polydactyly (HP:0001841)1.67373914
181Flat cornea (HP:0007720)1.66297426
182Broad toe (HP:0001837)1.65630522
183Intestinal atresia (HP:0011100)1.64707630
184Aplasia involving forearm bones (HP:0009822)1.64003484
185Absent forearm bone (HP:0003953)1.64003484
186Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.63248765
187Cutaneous syndactyly (HP:0012725)1.62346551
188Synostosis involving bones of the hand (HP:0004278)1.62171656
189Deviation of the hallux (HP:0010051)1.62123947
190Intestinal fistula (HP:0100819)1.61763408
191Broad finger (HP:0001500)1.61660934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.53373769
2LATS25.58095178
3FRK4.06428547
4STK38L4.01991282
5ERBB43.08512938
6ADRBK23.04168365
7GRK12.95191973
8INSRR2.82892318
9MAP3K62.72991542
10MAP4K22.69485614
11CDC72.56291053
12PLK42.50044100
13GRK72.43928425
14STK32.38732160
15CDK82.38302061
16TTK2.38043948
17WNK42.30283636
18DAPK22.02216821
19EEF2K1.99806959
20GRK51.94753287
21KSR21.85810126
22EPHA31.83177491
23MUSK1.78940738
24MAP3K131.78317887
25CHEK21.76475273
26KIT1.67670620
27DMPK1.67168983
28BRAF1.64713532
29WNK31.58922030
30STK391.55008118
31FGFR21.54474517
32CDK121.54294264
33TIE11.48192119
34ADRBK11.43904665
35MOS1.39849827
36NEK21.38997650
37PDGFRA1.36918458
38TAOK11.26968558
39BCR1.26860959
40PINK11.25085755
41TTN1.22086459
42DDR21.21851042
43MAP2K61.21013288
44TNIK1.19036351
45STK101.17808458
46BCKDK1.17632157
47CASK1.15472842
48PRKCE1.14986339
49PRKD31.10800651
50MELK1.10623374
51RAF11.09910040
52ACVR1B1.09304526
53PLK11.07287695
54KSR11.04204772
55OXSR11.02344828
56AKT31.01419696
57TAOK30.99633508
58TLK10.95067231
59TGFBR20.93947983
60PRKD20.92213827
61EPHB20.92154522
62MAPK130.92066671
63KDR0.91784633
64PAK30.91356758
65STK380.91353002
66PIK3CG0.90552507
67CSNK1G20.89483303
68CDK90.89420759
69MST40.88079819
70PLK30.87955557
71CSNK1A1L0.87338820
72CSNK1G30.85840425
73PAK40.84290519
74TRIM280.84027803
75ZAK0.82754208
76PRKCG0.82568063
77ERBB30.81756664
78TXK0.81626836
79NLK0.81491321
80WNK10.77759793
81PNCK0.77054664
82TRPM70.74525834
83SRPK10.73805713
84ABL20.73106329
85PDGFRB0.72867805
86MAP3K80.72140581
87EIF2AK20.71786149
88IKBKB0.70913308
89TGFBR10.70836404
90CDK70.70725563
91CHUK0.70216103
92BRSK20.70162988
93TRIB30.68808762
94MAPK150.68033741
95NEK90.67238626
96MARK20.67204272
97MAPKAPK30.66976747
98AURKB0.66535568
99NUAK10.66152116
100CHEK10.65945016
101FER0.65400694
102BMPR20.63335396
103PRKAA20.62638626
104PAK60.62433702
105TEC0.62227779
106ATM0.61946362
107PLK20.61838031
108FLT30.61837906
109MARK30.60678348
110MYLK0.58774507
111BMPR1B0.55572042
112MET0.54950486
113BRD40.53658451
114PIK3CA0.52399582
115VRK10.49924907
116CAMKK20.49834844
117MAP3K40.49623440
118MARK10.47982750
119CDK30.47838563
120PRKG10.47441756
121RPS6KA50.47210689
122TYRO30.47199486
123NTRK20.46331644
124PRKACA0.46044567
125RPS6KB20.45746670
126CSNK1G10.44825408
127ROCK10.43492213
128STK240.43043830
129MKNK10.42825657
130PRKAA10.42216262
131ATR0.41974325
132CSNK1A10.41944104
133MST1R0.41864666
134PRKCQ0.41657136
135FGR0.40375195
136ABL10.40261880
137MKNK20.39400932
138MAPK110.38292059
139DYRK20.38070425
140CDK10.36405291
141SGK20.35981560
142PRKCH0.35950725
143CAMK2A0.35348832
144PRKCA0.35328784
145CSNK1D0.34666710
146CDK20.33324951
147AURKA0.33164790
148MAPKAPK50.33112983
149AKT10.31902791
150IGF1R0.30466244
151BUB10.29203145
152PTK2B0.29150327
153PHKG10.28734123
154PHKG20.28734123
155CDK40.28444087
156MAP3K90.27894799
157PTK20.26574633
158MTOR0.25772809
159PAK10.25512433
160MAP2K70.25194572
161MAPK10.25158657

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.16895509
2Phototransduction_Homo sapiens_hsa047442.86306739
3TGF-beta signaling pathway_Homo sapiens_hsa043502.46456138
4ABC transporters_Homo sapiens_hsa020102.39704485
5Ovarian steroidogenesis_Homo sapiens_hsa049132.36271562
6RNA degradation_Homo sapiens_hsa030182.35863715
7Basal transcription factors_Homo sapiens_hsa030222.32813036
8Adherens junction_Homo sapiens_hsa045202.14565217
9Hippo signaling pathway_Homo sapiens_hsa043902.10164084
10Nitrogen metabolism_Homo sapiens_hsa009102.10152362
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.06863003
12Pancreatic cancer_Homo sapiens_hsa052122.04467624
13Selenocompound metabolism_Homo sapiens_hsa004501.93628129
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92272860
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.91870396
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91654130
17MicroRNAs in cancer_Homo sapiens_hsa052061.91475907
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87742199
19Fanconi anemia pathway_Homo sapiens_hsa034601.87060773
20Protein export_Homo sapiens_hsa030601.85587741
21Butanoate metabolism_Homo sapiens_hsa006501.84862537
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84826392
23Basal cell carcinoma_Homo sapiens_hsa052171.80215267
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74397388
25Nicotine addiction_Homo sapiens_hsa050331.72451627
26Tryptophan metabolism_Homo sapiens_hsa003801.69665783
27Graft-versus-host disease_Homo sapiens_hsa053321.67786311
28Circadian rhythm_Homo sapiens_hsa047101.62896272
29p53 signaling pathway_Homo sapiens_hsa041151.61167157
30ECM-receptor interaction_Homo sapiens_hsa045121.60737338
31Asthma_Homo sapiens_hsa053101.56282116
32Colorectal cancer_Homo sapiens_hsa052101.55515875
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.54512473
34Primary immunodeficiency_Homo sapiens_hsa053401.54343560
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.51768538
36RNA transport_Homo sapiens_hsa030131.51421069
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50318600
38Hedgehog signaling pathway_Homo sapiens_hsa043401.49345595
39Homologous recombination_Homo sapiens_hsa034401.48261013
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48104525
41Taste transduction_Homo sapiens_hsa047421.46014325
42Focal adhesion_Homo sapiens_hsa045101.45192941
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43775188
44Small cell lung cancer_Homo sapiens_hsa052221.39195539
45Renal cell carcinoma_Homo sapiens_hsa052111.38250696
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35389482
47Base excision repair_Homo sapiens_hsa034101.31475014
48Autoimmune thyroid disease_Homo sapiens_hsa053201.29756377
49Dorso-ventral axis formation_Homo sapiens_hsa043201.29707497
50Melanoma_Homo sapiens_hsa052181.28730337
51Oocyte meiosis_Homo sapiens_hsa041141.27547598
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27440135
53Bladder cancer_Homo sapiens_hsa052191.26408656
54Wnt signaling pathway_Homo sapiens_hsa043101.23784531
55Mineral absorption_Homo sapiens_hsa049781.23069788
56Non-homologous end-joining_Homo sapiens_hsa034501.22342092
57Regulation of autophagy_Homo sapiens_hsa041401.21106697
58Notch signaling pathway_Homo sapiens_hsa043301.19862969
59HTLV-I infection_Homo sapiens_hsa051661.17618590
60Allograft rejection_Homo sapiens_hsa053301.16742262
61Cardiac muscle contraction_Homo sapiens_hsa042601.15851842
62Pathways in cancer_Homo sapiens_hsa052001.15214188
63Olfactory transduction_Homo sapiens_hsa047401.14559340
64Insulin secretion_Homo sapiens_hsa049111.12431609
65Antigen processing and presentation_Homo sapiens_hsa046121.11516725
66mRNA surveillance pathway_Homo sapiens_hsa030151.10800926
67Endometrial cancer_Homo sapiens_hsa052131.10380605
68Ether lipid metabolism_Homo sapiens_hsa005651.08826750
69Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08305491
70Morphine addiction_Homo sapiens_hsa050321.07161237
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06978413
72Salivary secretion_Homo sapiens_hsa049701.06059417
73Prostate cancer_Homo sapiens_hsa052151.05286196
74Choline metabolism in cancer_Homo sapiens_hsa052311.05146517
75Chronic myeloid leukemia_Homo sapiens_hsa052201.04785135
76GnRH signaling pathway_Homo sapiens_hsa049121.02574947
77Ras signaling pathway_Homo sapiens_hsa040141.02070482
78Proteoglycans in cancer_Homo sapiens_hsa052051.01859247
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00961174
80beta-Alanine metabolism_Homo sapiens_hsa004101.00263278
81Retinol metabolism_Homo sapiens_hsa008301.00059740
82Proteasome_Homo sapiens_hsa030500.99950030
83Caffeine metabolism_Homo sapiens_hsa002320.98775589
84Chemical carcinogenesis_Homo sapiens_hsa052040.98698510
85Tight junction_Homo sapiens_hsa045300.97752753
86Oxidative phosphorylation_Homo sapiens_hsa001900.97679303
87Type I diabetes mellitus_Homo sapiens_hsa049400.96546363
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96416546
89FoxO signaling pathway_Homo sapiens_hsa040680.96375402
90Vitamin B6 metabolism_Homo sapiens_hsa007500.96122254
91Thyroid cancer_Homo sapiens_hsa052160.95954367
92Rap1 signaling pathway_Homo sapiens_hsa040150.94968376
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94380191
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.94176254
95DNA replication_Homo sapiens_hsa030300.93817419
96Histidine metabolism_Homo sapiens_hsa003400.93071500
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92567431
98Axon guidance_Homo sapiens_hsa043600.92090312
99Propanoate metabolism_Homo sapiens_hsa006400.91632339
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91077534
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90752461
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90729038
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89758381
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88744845
105VEGF signaling pathway_Homo sapiens_hsa043700.86991372
106Prolactin signaling pathway_Homo sapiens_hsa049170.86106577
107Melanogenesis_Homo sapiens_hsa049160.85521023
108GABAergic synapse_Homo sapiens_hsa047270.85028795
109Renin secretion_Homo sapiens_hsa049240.84962693
110Mismatch repair_Homo sapiens_hsa034300.82722996
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81930885
112Linoleic acid metabolism_Homo sapiens_hsa005910.81602221
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.81183103
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.80506495
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79972959
116mTOR signaling pathway_Homo sapiens_hsa041500.79826547
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79273296
118Arachidonic acid metabolism_Homo sapiens_hsa005900.79119469
119Long-term depression_Homo sapiens_hsa047300.78285716
120Malaria_Homo sapiens_hsa051440.78199359
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77250980
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76827013
123Dilated cardiomyopathy_Homo sapiens_hsa054140.76691131
124Herpes simplex infection_Homo sapiens_hsa051680.76059241
125Serotonergic synapse_Homo sapiens_hsa047260.74603740
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74272126
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74097551
128Peroxisome_Homo sapiens_hsa041460.73541593
129Platelet activation_Homo sapiens_hsa046110.73034638
130Glioma_Homo sapiens_hsa052140.72114344
131Nucleotide excision repair_Homo sapiens_hsa034200.71985701
132Non-small cell lung cancer_Homo sapiens_hsa052230.70532091
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.70148180
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70082972
135MAPK signaling pathway_Homo sapiens_hsa040100.69324070
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69211189
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68447795
138Hepatitis B_Homo sapiens_hsa051610.67650000
139Viral carcinogenesis_Homo sapiens_hsa052030.67181516
140Circadian entrainment_Homo sapiens_hsa047130.65829748
141Amoebiasis_Homo sapiens_hsa051460.65304513
142Glutamatergic synapse_Homo sapiens_hsa047240.64868213
143Spliceosome_Homo sapiens_hsa030400.63039315
144Rheumatoid arthritis_Homo sapiens_hsa053230.62181152
145Shigellosis_Homo sapiens_hsa051310.61507842
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61212231
147Viral myocarditis_Homo sapiens_hsa054160.60721098
148Calcium signaling pathway_Homo sapiens_hsa040200.60705070
149TNF signaling pathway_Homo sapiens_hsa046680.60555162
150ErbB signaling pathway_Homo sapiens_hsa040120.58990652
151Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56062484
152Complement and coagulation cascades_Homo sapiens_hsa046100.53712851
153Parkinsons disease_Homo sapiens_hsa050120.53007226
154Estrogen signaling pathway_Homo sapiens_hsa049150.52875713
155Protein digestion and absorption_Homo sapiens_hsa049740.50665346
156Fatty acid degradation_Homo sapiens_hsa000710.50301551
157Lysine degradation_Homo sapiens_hsa003100.50156934
158Tyrosine metabolism_Homo sapiens_hsa003500.49472631
159Gastric acid secretion_Homo sapiens_hsa049710.49386803
160Sulfur metabolism_Homo sapiens_hsa009200.48915174
161Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48301937
162Leukocyte transendothelial migration_Homo sapiens_hsa046700.47177197
163Huntingtons disease_Homo sapiens_hsa050160.46485008
164RNA polymerase_Homo sapiens_hsa030200.46115259
165Toxoplasmosis_Homo sapiens_hsa051450.45973937
166Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44354430
167cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43602925
168Hematopoietic cell lineage_Homo sapiens_hsa046400.43488464
169Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43118273
170Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40623827
171Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39646784
172cAMP signaling pathway_Homo sapiens_hsa040240.39035415
173Oxytocin signaling pathway_Homo sapiens_hsa049210.37149038
174Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36182220

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