ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cardiac myofibril assembly (GO:0055003)	7.33556411
2	sarcomere organization (GO:0045214)	6.84227978
3	cardiac right ventricle morphogenesis (GO:0003215)	6.47039260
4	myofibril assembly (GO:0030239)	6.33242436
5	* atrial septum morphogenesis (GO:0060413)	6.28395717
6	cardiac muscle hypertrophy (GO:0003300)	6.23127705
7	muscle filament sliding (GO:0030049)	6.19568706
8	actin-myosin filament sliding (GO:0033275)	6.19568706
9	* regulation of cardioblast differentiation (GO:0051890)	5.92572290
10	regulation of relaxation of muscle (GO:1901077)	5.85806802
11	striated muscle hypertrophy (GO:0014897)	5.82364230
12	cardiac muscle tissue morphogenesis (GO:0055008)	5.76172908
13	actin-mediated cell contraction (GO:0070252)	5.59191923
14	* cardiac chamber formation (GO:0003207)	5.52615490
15	cardiac muscle contraction (GO:0060048)	5.41605545
16	muscle hypertrophy (GO:0014896)	5.34255707
17	muscle tissue morphogenesis (GO:0060415)	5.14029875
18	ventricular cardiac muscle tissue morphogenesis (GO:0055010)	5.03933517
19	outflow tract septum morphogenesis (GO:0003148)	5.02345022
20	regulation of sarcomere organization (GO:0060297)	4.98064089
21	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	4.93095534
22	* positive regulation of cardiac muscle cell proliferation (GO:0060045)	4.85217300
23	venous blood vessel morphogenesis (GO:0048845)	4.84576514
24	* positive regulation of cardiac muscle tissue growth (GO:0055023)	4.73623946
25	heart valve formation (GO:0003188)	4.72493343
26	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	4.66798399
27	endocardial cushion morphogenesis (GO:0003203)	4.65606994
28	adult heart development (GO:0007512)	4.58104351
29	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.56712002
30	basement membrane organization (GO:0071711)	4.56427465
31	actomyosin structure organization (GO:0031032)	4.54030500
32	regulation of actin filament-based movement (GO:1903115)	4.54023661
33	cardiac muscle adaptation (GO:0014887)	4.48121510
34	cardiac muscle hypertrophy in response to stress (GO:0014898)	4.48121510
35	muscle hypertrophy in response to stress (GO:0003299)	4.48121510
36	* positive regulation of cardiac muscle tissue development (GO:0055025)	4.46941649
37	ventricular cardiac muscle cell development (GO:0055015)	4.45146197
38	endoderm formation (GO:0001706)	4.40043809
39	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	4.38166070
40	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	4.35365335
41	cardiac muscle cell development (GO:0055013)	4.33267863
42	relaxation of smooth muscle (GO:0044557)	4.29538020
43	actin filament-based movement (GO:0030048)	4.29223462
44	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	4.28451245
45	* cell migration involved in heart development (GO:0060973)	4.24917218
46	* positive regulation of heart growth (GO:0060421)	4.20525032
47	* atrioventricular valve morphogenesis (GO:0003181)	4.15598214
48	mesenchyme morphogenesis (GO:0072132)	4.11248134
49	regulation of skeletal muscle contraction (GO:0014819)	4.09147178
50	cardiac cell development (GO:0055006)	4.08133706
51	* cardiac septum development (GO:0003279)	4.06526948
52	protein heterotrimerization (GO:0070208)	4.06334254
53	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	4.02768186
54	collagen fibril organization (GO:0030199)	4.01818517
55	regulation of the force of heart contraction (GO:0002026)	4.00502986
56	striated muscle contraction (GO:0006941)	3.92864282
57	regulation of striated muscle contraction (GO:0006942)	3.88487194
58	sarcoplasmic reticulum calcium ion transport (GO:0070296)	3.84209073
59	negative regulation of potassium ion transmembrane transport (GO:1901380)	3.79078393
60	regulation of cell communication by electrical coupling (GO:0010649)	3.78231358
61	ventricular cardiac muscle cell action potential (GO:0086005)	3.73160381
62	* heart valve morphogenesis (GO:0003179)	3.71421701
63	negative regulation of striated muscle cell apoptotic process (GO:0010664)	3.69782845
64	regulation of cardiac muscle cell contraction (GO:0086004)	3.61779209
65	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.61732062
66	* regulation of cardiac muscle cell proliferation (GO:0060043)	3.60850613
67	bone trabecula formation (GO:0060346)	3.59952965
68	heart contraction (GO:0060047)	3.59947857
69	heart process (GO:0003015)	3.59947857
70	regulation of cardiac muscle contraction (GO:0055117)	3.57088663
71	extracellular matrix assembly (GO:0085029)	3.53773382
72	desmosome organization (GO:0002934)	3.53264982
73	morphogenesis of an epithelial sheet (GO:0002011)	3.47609855
74	trabecula formation (GO:0060343)	3.44354246
75	fibroblast migration (GO:0010761)	3.43562619
76	* regulation of cardiac muscle tissue growth (GO:0055021)	3.42778926
77	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	3.40565315
78	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.39058276
79	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	3.37335406
80	* regulation of cardiac muscle tissue development (GO:0055024)	3.36309432
81	negative regulation of protein localization to cell surface (GO:2000009)	3.35276603
82	sequestering of extracellular ligand from receptor (GO:0035581)	3.32295319
83	* positive regulation of muscle tissue development (GO:1901863)	3.21780400
84	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.21426327
85	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	3.21273456
86	cell communication involved in cardiac conduction (GO:0086065)	3.17830226
87	cGMP-mediated signaling (GO:0019934)	3.17304961
88	* positive regulation of muscle organ development (GO:0048636)	3.16911590
89	* positive regulation of striated muscle tissue development (GO:0045844)	3.16911590
90	regulation of cardiac muscle cell differentiation (GO:2000725)	3.15367049
91	* cardiac muscle tissue development (GO:0048738)	3.13786260
92	cardiac muscle cell action potential (GO:0086001)	3.12812744
93	positive regulation of heart rate (GO:0010460)	3.11910150
94	* regulation of heart growth (GO:0060420)	3.10727223
95	regulation of muscle contraction (GO:0006937)	3.10691720
96	negative regulation of hormone biosynthetic process (GO:0032353)	3.09566405
97	regulation of heart contraction (GO:0008016)	3.06470185
98	heart trabecula formation (GO:0060347)	3.05180303
99	regulation of ATPase activity (GO:0043462)	3.04370987
100	regulation of ATP catabolic process (GO:1903289)	3.04370987
101	regulation of tight junction assembly (GO:2000810)	3.02396078
102	negative regulation of cardiac muscle hypertrophy (GO:0010614)	3.02352106
103	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.99452085
104	cell communication by electrical coupling (GO:0010644)	2.99154345
105	kidney mesenchyme development (GO:0072074)	2.97084068
106	skin morphogenesis (GO:0043589)	2.94783746
107	* ventricular septum development (GO:0003281)	2.94596677
108	* endocardial cushion development (GO:0003197)	2.93712284
109	positive regulation of heart contraction (GO:0045823)	2.91935162
110	relaxation of muscle (GO:0090075)	2.91875379
111	* positive regulation of organ growth (GO:0046622)	2.91206472
112	regulation of heart rate (GO:0002027)	2.91060166
113	regulation of cardiac muscle cell apoptotic process (GO:0010665)	2.89559829
114	striated muscle adaptation (GO:0014888)	2.89411528
115	relaxation of cardiac muscle (GO:0055119)	2.87803971
116	regulation of muscle system process (GO:0090257)	2.87604141
117	metanephric mesenchyme development (GO:0072075)	2.85966917
118	regulation of membrane repolarization (GO:0060306)	2.85802859
119	response to redox state (GO:0051775)	2.84801631
120	endodermal cell differentiation (GO:0035987)	2.82927793
121	cardiac conduction (GO:0061337)	2.82847535
122	cardiac muscle cell action potential involved in contraction (GO:0086002)	2.81799000
123	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	2.80255384
124	cellular response to epinephrine stimulus (GO:0071872)	2.79202387
125	endothelial cell morphogenesis (GO:0001886)	2.77681550
126	paraxial mesoderm development (GO:0048339)	2.74707004
127	striated muscle cell development (GO:0055002)	2.72137822
128	negative regulation of hormone metabolic process (GO:0032351)	2.68778935

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* EP300_21415370_ChIP-Seq_HL-1_Mouse	3.82880975
2	TRIM28_21343339_ChIP-Seq_HEK293_Human	3.08612578
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.07299029
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.93478692
5	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.86232532
6	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.84942436
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.77690601
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.41154067
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.24308038
10	* EED_16625203_ChIP-ChIP_MESCs_Mouse	2.21423511
11	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.21312264
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.20848266
13	* EZH2_27304074_Chip-Seq_ESCs_Mouse	2.16059200
14	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.09948898
15	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	2.07706373
16	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.07044104
17	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.06483467
18	* SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.97988369
19	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.96548987
20	BRD4_25478319_ChIP-Seq_HGPS_Human	1.95189632
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.94059689
22	* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.92716348
23	* SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.90440248
24	* PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.90142660
25	* SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.82232981
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.80235775
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.79554329
28	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.77609624
29	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.77495634
30	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.77495634
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.75099050
32	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.74466584
33	* CBX2_27304074_Chip-Seq_ESCs_Mouse	1.71572457
34	FUS_26573619_Chip-Seq_HEK293_Human	1.70009218
35	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.67636663
36	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.65957902
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.65839098
38	* RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.65140958
39	TP53_16413492_ChIP-PET_HCT116_Human	1.64469374
40	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.64040514
41	TP53_18474530_ChIP-ChIP_U2OS_Human	1.62554206
42	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.61149863
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57046100
44	* RNF2_27304074_Chip-Seq_ESCs_Mouse	1.55763681
45	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.52774675
46	TAF15_26573619_Chip-Seq_HEK293_Human	1.52353615
47	P300_19829295_ChIP-Seq_ESCs_Human	1.51792601
48	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.46676775
49	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.45001224
50	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.45001224
51	* JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.44423622
52	* EZH2_27294783_Chip-Seq_ESCs_Mouse	1.43870653
53	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43803272
54	* ISL1_27105846_Chip-Seq_CPCs_Mouse	1.42171099
55	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.41404010
56	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.39304135
57	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.38059669
58	BCAT_22108803_ChIP-Seq_LS180_Human	1.36191243
59	* MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.34892832
60	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34641633
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31531713
62	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.31207596
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30915864
64	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.29937638
65	AHR_22903824_ChIP-Seq_MCF-7_Human	1.29852008
66	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.29619952
67	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.27886241
68	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.27194157
69	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.27089357
70	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.26603880
71	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.26354023
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25917655
73	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.24813119
74	CJUN_26792858_Chip-Seq_BT549_Human	1.24716101
75	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.23405379
76	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.21775475
77	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.21710245
78	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.21644695
79	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.21474132
80	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21192366
81	CLOCK_20551151_ChIP-Seq_293T_Human	1.20992285
82	* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20794939
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20134701
84	STAT3_23295773_ChIP-Seq_U87_Human	1.19529894
85	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.19451432
86	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.18782022
87	* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18573442
88	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.17926745
89	* TP53_20018659_ChIP-ChIP_R1E_Mouse	1.17671438
90	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.15685693
91	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.15685693
92	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.15426508
93	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12955455
94	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.12396597
95	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12175360
96	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11556429
97	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10077499
98	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.09764410
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09642595
100	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.08343369
101	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.08108296
102	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.07777002
103	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07754525
104	* TCF4_23295773_ChIP-Seq_U87_Human	1.06293283
105	GATA4_21415370_ChIP-Seq_HL-1_Mouse	1.06184907
106	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.06184619
107	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.06037243
108	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.06035322
109	AR_21572438_ChIP-Seq_LNCaP_Human	1.05922075
110	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.05920349
111	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05291518
112	* SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.05290155
113	ER_23166858_ChIP-Seq_MCF-7_Human	1.05065112
114	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.04752277
115	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.04151655
116	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.03984806
117	* SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.03865788
118	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03818301
119	VDR_24787735_ChIP-Seq_THP-1_Human	1.03753269
120	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02549360
121	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02173732
122	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.01836591
123	SA1_22415368_ChIP-Seq_MEFs_Mouse	1.01547517
124	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.00721476
125	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.98011803
126	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.94205279
127	* RING1B_27294783_Chip-Seq_ESCs_Mouse	0.93591930
128	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.93265002
129	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.93211855
130	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.92887552
131	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.90484671
132	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.89004921
133	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.88302966
134	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.87126159
135	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.86064770
136	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.82928279
137	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.82395757

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008438_abnormal_cutaneous_collagen	5.24566753
2	MP0004084_abnormal_cardiac_muscle	4.90321924
3	MP0004215_abnormal_myocardial_fiber	3.96638503
4	MP0005275_abnormal_skin_tensile	3.75699517
5	MP0002837_dystrophic_cardiac_calcinosis	3.68091649
6	MP0000751_myopathy	3.67885928
7	MP0005330_cardiomyopathy	3.64384073
8	MP0003828_pulmonary_edema	3.48735119
9	MP0000749_muscle_degeneration	3.40540330
10	MP0002972_abnormal_cardiac_muscle	3.38936407
11	MP0008775_abnormal_heart_ventricle	3.37565641
12	MP0004510_myositis	3.32347311
13	MP0004036_abnormal_muscle_relaxation	3.30596174
14	MP0003567_abnormal_fetal_cardiomyocyte	3.14897607
15	MP0001958_emphysema	3.09377601
16	MP0002127_abnormal_cardiovascular_syste	2.76220587
17	* MP0003137_abnormal_impulse_conducting	2.68870651
18	MP0003941_abnormal_skin_development	2.67039431
19	MP0005620_abnormal_muscle_contractility	2.62356944
20	MP0006138_congestive_heart_failure	2.61673859
21	MP0003705_abnormal_hypodermis_morpholog	2.46671831
22	MP0010630_abnormal_cardiac_muscle	2.40364869
23	* MP0005385_cardiovascular_system_phenoty	2.39782486
24	* MP0001544_abnormal_cardiovascular_syste	2.39782486
25	MP0004484_altered_response_of	2.30880582
26	* MP0004085_abnormal_heartbeat	2.28006670
27	MP0001542_abnormal_bone_strength	2.22058493
28	MP0003950_abnormal_plasma_membrane	2.17490358
29	MP0003646_muscle_fatigue	2.16994407
30	MP0004087_abnormal_muscle_fiber	2.14103548
31	MP0009384_cardiac_valve_regurgitation	2.08109686
32	MP0002106_abnormal_muscle_physiology	2.01515632
33	MP0003283_abnormal_digestive_organ	1.99455414
34	MP0004272_abnormal_basement_membrane	1.95484594
35	MP0003385_abnormal_body_wall	1.91646917
36	MP0004145_abnormal_muscle_electrophysio	1.90113539
37	MP0005623_abnormal_meninges_morphology	1.83381055
38	MP0006054_spinal_hemorrhage	1.83119839
39	MP0002295_abnormal_pulmonary_circulatio	1.83021458
40	MP0003122_maternal_imprinting	1.72651850
41	* MP0005369_muscle_phenotype	1.66359328
42	MP0000767_abnormal_smooth_muscle	1.64959206
43	MP0000566_synostosis	1.62067114
44	MP0010368_abnormal_lymphatic_system	1.54954241
45	MP0005248_abnormal_Harderian_gland	1.47159729
46	MP0003221_abnormal_cardiomyocyte_apopto	1.44464990
47	MP0002102_abnormal_ear_morphology	1.43839519
48	MP0005023_abnormal_wound_healing	1.39135486
49	MP0002269_muscular_atrophy	1.35916670
50	MP0000750_abnormal_muscle_regeneration	1.35525089
51	MP0001348_abnormal_lacrimal_gland	1.33197964
52	MP0003279_aneurysm	1.26036960
53	MP0010030_abnormal_orbit_morphology	1.22027966
54	MP0009780_abnormal_chondrocyte_physiolo	1.20943055
55	MP0004233_abnormal_muscle_weight	1.18508046
56	* MP0009250_abnormal_appendicular_skeleto	1.17233383
57	MP0005367_renal/urinary_system_phenotyp	1.16492515
58	MP0000516_abnormal_urinary_system	1.16492515
59	MP0005451_abnormal_body_composition	1.14177854
60	* MP0000266_abnormal_heart_morphology	1.13101519
61	MP0000759_abnormal_skeletal_muscle	1.08673715
62	MP0000534_abnormal_ureter_morphology	1.08017022
63	MP0003136_yellow_coat_color	1.07696576
64	MP0002128_abnormal_blood_circulation	1.05581813
65	MP0003566_abnormal_cell_adhesion	1.05245694
66	MP0005409_darkened_coat_color	1.02709084
67	MP0000013_abnormal_adipose_tissue	1.01374615
68	MP0008004_abnormal_stomach_pH	0.99232117
69	MP0002896_abnormal_bone_mineralization	0.98844592
70	MP0003942_abnormal_urinary_system	0.97504872
71	MP0002234_abnormal_pharynx_morphology	0.96935322
72	MP0009697_abnormal_copulation	0.96293065
73	MP0004130_abnormal_muscle_cell	0.95758370
74	MP0001879_abnormal_lymphatic_vessel	0.94183348
75	MP0002133_abnormal_respiratory_system	0.94123734
76	MP0005388_respiratory_system_phenotype	0.94123734
77	MP0000747_muscle_weakness	0.91393132
78	MP0000462_abnormal_digestive_system	0.90097590
79	MP0000383_abnormal_hair_follicle	0.89646280
80	MP0003935_abnormal_craniofacial_develop	0.88619221
81	* MP0003937_abnormal_limbs/digits/tail_de	0.88479167
82	* MP0002925_abnormal_cardiovascular_devel	0.86006767
83	MP0002249_abnormal_larynx_morphology	0.85424481
84	MP0001188_hyperpigmentation	0.83794761
85	MP0003121_genomic_imprinting	0.83092801
86	MP0005165_increased_susceptibility_to	0.81330052
87	MP0003115_abnormal_respiratory_system	0.81028695
88	MP0001243_abnormal_dermal_layer	0.80510893
89	MP0005171_absent_coat_pigmentation	0.79878006
90	* MP0005390_skeleton_phenotype	0.79204695
91	MP0005595_abnormal_vascular_smooth	0.77310888
92	MP0000230_abnormal_systemic_arterial	0.77164200
93	MP0000343_altered_response_to	0.77130024
94	MP0004134_abnormal_chest_morphology	0.76719263
95	MP0000049_abnormal_middle_ear	0.75033702
96	MP0005670_abnormal_white_adipose	0.74381162
97	* MP0005503_abnormal_tendon_morphology	0.73628240
98	MP0002060_abnormal_skin_morphology	0.71836840
99	MP0002089_abnormal_postnatal_growth/wei	0.71683130
100	MP0001175_abnormal_lung_morphology	0.71118069
101	MP0006292_abnormal_olfactory_placode	0.70421088
102	MP0000762_abnormal_tongue_morphology	0.69590672
103	MP0001661_extended_life_span	0.68019439
104	MP0005187_abnormal_penis_morphology	0.65277244
105	MP0002254_reproductive_system_inflammat	0.64504868
106	* MP0005508_abnormal_skeleton_morphology	0.63146105
107	MP0001614_abnormal_blood_vessel	0.63103083
108	MP0004782_abnormal_surfactant_physiolog	0.62981353
109	MP0000428_abnormal_craniofacial_morphol	0.62833969
110	* MP0002108_abnormal_muscle_morphology	0.62170001
111	MP0000003_abnormal_adipose_tissue	0.61535240
112	* MP0001784_abnormal_fluid_regulation	0.61439349
113	MP0009053_abnormal_anal_canal	0.60876735
114	* MP0002109_abnormal_limb_morphology	0.60086196
115	MP0005164_abnormal_response_to	0.59745930
116	MP0005257_abnormal_intraocular_pressure	0.59274244
117	MP0000733_abnormal_muscle_development	0.58020673
118	MP0001299_abnormal_eye_distance/	0.57633109
119	MP0000163_abnormal_cartilage_morphology	0.56818918
120	MP0002938_white_spotting	0.54470745
121	MP0001177_atelectasis	0.54214890
122	MP0003091_abnormal_cell_migration	0.53898194
123	MP0002233_abnormal_nose_morphology	0.51875822
124	MP0003755_abnormal_palate_morphology	0.49456991
125	MP0002282_abnormal_trachea_morphology	0.47303911
126	* MP0002115_abnormal_skeleton_extremities	0.44925925
127	MP0000432_abnormal_head_morphology	0.44296453
128	MP0002933_joint_inflammation	0.43479308

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Sudden death (HP:0001699)	8.48725097
2	Right ventricular cardiomyopathy (HP:0011663)	6.67005952
3	Atrial fibrillation (HP:0005110)	6.60883203
4	Ventricular tachycardia (HP:0004756)	6.35903526
5	Primary atrial arrhythmia (HP:0001692)	6.11161160
6	Supraventricular tachycardia (HP:0004755)	5.83777355
7	Supraventricular arrhythmia (HP:0005115)	5.69962832
8	Calf muscle hypertrophy (HP:0008981)	5.65737503
9	Lipoatrophy (HP:0100578)	5.28541019
10	Protrusio acetabuli (HP:0003179)	5.20086018
11	Abnormality of the calf musculature (HP:0001430)	5.16259125
12	Muscle hypertrophy of the lower extremities (HP:0008968)	5.00874610
13	Premature rupture of membranes (HP:0001788)	4.95546462
14	Syncope (HP:0001279)	4.67210157
15	Aortic aneurysm (HP:0004942)	4.63696699
16	Muscle fiber splitting (HP:0003555)	4.50881077
17	Type 1 muscle fiber predominance (HP:0003803)	4.38830378
18	Pulmonary artery stenosis (HP:0004415)	4.36188279
19	Dilated cardiomyopathy (HP:0001644)	4.12417110
20	Prolonged QT interval (HP:0001657)	4.12038058
21	Subaortic stenosis (HP:0001682)	4.10889938
22	Abnormality of the left ventricular outflow tract (HP:0011103)	4.10889938
23	Patent foramen ovale (HP:0001655)	4.04578066
24	Aortic dissection (HP:0002647)	3.88652237
25	Vascular tortuosity (HP:0004948)	3.87090808
26	Ankle contracture (HP:0006466)	3.71611056
27	Hyporeflexia of lower limbs (HP:0002600)	3.68719159
28	* Hypoplastic left heart (HP:0004383)	3.67053772
29	Aplasia cutis congenita (HP:0001057)	3.64848526
30	Ventricular arrhythmia (HP:0004308)	3.56551194
31	EMG: myopathic abnormalities (HP:0003458)	3.45741228
32	Exercise-induced muscle cramps (HP:0003710)	3.38670625
33	Follicular hyperkeratosis (HP:0007502)	3.32712893
34	Soft skin (HP:0000977)	3.31811263
35	Wormian bones (HP:0002645)	3.16804580
36	Bladder diverticulum (HP:0000015)	3.15662719
37	Mildly elevated creatine phosphokinase (HP:0008180)	3.15036818
38	Arterial tortuosity (HP:0005116)	3.10996759
39	Increased variability in muscle fiber diameter (HP:0003557)	3.03440825
40	Left ventricular hypertrophy (HP:0001712)	3.02439118
41	Neonatal short-limb short stature (HP:0008921)	3.00128010
42	* Hypoplastic heart (HP:0001961)	2.91091860
43	Heart block (HP:0012722)	2.91015664
44	Exercise-induced myalgia (HP:0003738)	2.89716372
45	Spinal rigidity (HP:0003306)	2.87157243
46	Atrioventricular block (HP:0001678)	2.85352849
47	Abnormal EKG (HP:0003115)	2.84390874
48	Wide anterior fontanel (HP:0000260)	2.75532249
49	Preauricular pit (HP:0004467)	2.75109795
50	Periauricular skin pits (HP:0100277)	2.75109795
51	Osteomalacia (HP:0002749)	2.74698189
52	Spondylolisthesis (HP:0003302)	2.72765191
53	Abnormal atrioventricular conduction (HP:0005150)	2.69863617
54	Increased connective tissue (HP:0009025)	2.66435379
55	Palpitations (HP:0001962)	2.60218310
56	Hypoplastic ischia (HP:0003175)	2.57766590
57	Abnormal ventriculo-arterial connection (HP:0011563)	2.56289431
58	Transposition of the great arteries (HP:0001669)	2.56289431
59	Abnormal connection of the cardiac segments (HP:0011545)	2.56289431
60	Aneurysm (HP:0002617)	2.55039771
61	Shallow orbits (HP:0000586)	2.53261439
62	Abnormality of skeletal muscle fiber size (HP:0012084)	2.51901469
63	Palmoplantar keratoderma (HP:0000982)	2.51677143
64	Atrophic scars (HP:0001075)	2.46772431
65	Dilatation of the ascending aorta (HP:0005111)	2.44838790
66	Abnormality of dentin (HP:0010299)	2.43902064
67	Bell-shaped thorax (HP:0001591)	2.41831435
68	Muscular dystrophy (HP:0003560)	2.41388325
69	Slender build (HP:0001533)	2.39953505
70	Absent frontal sinuses (HP:0002688)	2.37741162
71	Wrist flexion contracture (HP:0001239)	2.37016822
72	Coronal craniosynostosis (HP:0004440)	2.32734962
73	Midline defect of the nose (HP:0004122)	2.32549219
74	Bundle branch block (HP:0011710)	2.30890659
75	Fragile skin (HP:0001030)	2.28653974
76	Abnormality of the tricuspid valve (HP:0001702)	2.27241536
77	Mesomelia (HP:0003027)	2.24529365
78	Mitral valve prolapse (HP:0001634)	2.23737370
79	Cortical dysplasia (HP:0002539)	2.21020212
80	Congenital malformation of the right heart (HP:0011723)	2.20959854
81	Double outlet right ventricle (HP:0001719)	2.20959854
82	Bowel diverticulosis (HP:0005222)	2.16662595
83	Overgrowth (HP:0001548)	2.16184817
84	Abnormality of the right ventricle (HP:0001707)	2.16044859
85	Decreased circulating renin level (HP:0003351)	2.15908193
86	Abnormality of the ischium (HP:0003174)	2.14823211
87	Pulmonic stenosis (HP:0001642)	2.12512775
88	Blue sclerae (HP:0000592)	2.08483713
89	Peritonitis (HP:0002586)	2.07313385
90	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.07245727
91	Ulnar bowing (HP:0003031)	2.07034585
92	Elbow flexion contracture (HP:0002987)	2.06195607
93	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.05387048
94	Osteolytic defects of the hand bones (HP:0009699)	2.05387048
95	Distal lower limb muscle weakness (HP:0009053)	2.03434104
96	Congestive heart failure (HP:0001635)	2.02383158
97	Neck muscle weakness (HP:0000467)	2.02267709
98	Preaxial foot polydactyly (HP:0001841)	2.02141524
99	Genu recurvatum (HP:0002816)	2.01995676
100	Asymmetric septal hypertrophy (HP:0001670)	2.00872641
101	Ventricular fibrillation (HP:0001663)	2.00704596
102	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.00087214
103	Cervical subluxation (HP:0003308)	1.99532694
104	Limited hip movement (HP:0008800)	1.98719300
105	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.98381627
106	Hypoventilation (HP:0002791)	1.98287495
107	Skin pits (HP:0100276)	1.96853657
108	Bradycardia (HP:0001662)	1.96220837
109	Metaphyseal dysplasia (HP:0100255)	1.96087774
110	Cupped ribs (HP:0000887)	1.95707420
111	Persistence of primary teeth (HP:0006335)	1.93933870
112	Diaphragmatic weakness (HP:0009113)	1.93269841
113	Joint laxity (HP:0001388)	1.92616182
114	Generalized muscle weakness (HP:0003324)	1.91161885
115	Sparse lateral eyebrow (HP:0005338)	1.90730862
116	Mitral regurgitation (HP:0001653)	1.86876343
117	Adactyly (HP:0009776)	1.85507636
118	Sudden cardiac death (HP:0001645)	1.85048545
119	Mild short stature (HP:0003502)	1.84377994
120	Vascular calcification (HP:0004934)	1.84170337
121	Long toe (HP:0010511)	1.83595231
122	Hip contracture (HP:0003273)	1.83248141
123	Renal cortical cysts (HP:0000803)	1.82346288
124	Steppage gait (HP:0003376)	1.81589957
125	Rimmed vacuoles (HP:0003805)	1.81054476
126	Hyperextensible skin (HP:0000974)	1.80395158
127	Coarctation of aorta (HP:0001680)	1.79995840
128	Knee flexion contracture (HP:0006380)	1.78993800
129	Abnormality of incisor morphology (HP:0011063)	1.76157626
130	Biconcave vertebral bodies (HP:0004586)	1.76149863
131	EMG: neuropathic changes (HP:0003445)	1.73938670
132	Aortic valve stenosis (HP:0001650)	1.73021134
133	Cardiovascular calcification (HP:0011915)	1.71350233
134	Infantile muscular hypotonia (HP:0008947)	1.70648083
135	Abnormality of the lacrimal duct (HP:0011481)	1.67117634
136	Abnormality of the pubic bones (HP:0003172)	1.65131814
137	Abnormality of the nasolacrimal system (HP:0000614)	1.63401106
138	Skull defect (HP:0001362)	1.60973834
139	Short middle phalanx of the 5th finger (HP:0004220)	1.57157172
140	Myotonia (HP:0002486)	1.54070622
141	Abnormality of the foot musculature (HP:0001436)	1.54032995
142	Broad metatarsal (HP:0001783)	1.53064036
143	Absent eyebrow (HP:0002223)	1.49028245
144	Absent hand (HP:0004050)	1.48178679
145	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.47494555
146	Abnormality of the nasal septum (HP:0000419)	1.45813209
147	Abnormality of the endocardium (HP:0004306)	1.44306405
148	Gowers sign (HP:0003391)	1.43416078
149	White forelock (HP:0002211)	1.41996838
150	Septo-optic dysplasia (HP:0100842)	1.41843590
151	Duplicated collecting system (HP:0000081)	1.40154420
152	Nasolacrimal duct obstruction (HP:0000579)	1.39266128
153	Morphological abnormality of the middle ear (HP:0008609)	1.38099324
154	Foot dorsiflexor weakness (HP:0009027)	1.38059904
155	Scapular winging (HP:0003691)	1.33465395
156	Abnormality of molar morphology (HP:0011070)	1.32265626
157	Abnormality of molar (HP:0011077)	1.32265626

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OBSCN	6.67940254
2	MYLK	4.18212947
3	ZAK	4.04093680
4	PIK3CA	3.36600254
5	STK24	2.87070347
6	DMPK	2.83407998
7	WNK4	2.65950654
8	PDGFRA	2.41191274
9	CASK	2.36986768
10	NUAK1	2.14446805
11	TTN	2.11981157
12	BCR	2.02947332
13	TIE1	2.00096763
14	PKN2	1.91947789
15	WNK1	1.84763075
16	MAP3K5	1.72474670
17	PHKG1	1.65598106
18	PHKG2	1.65598106
19	LATS1	1.64147727
20	GRK7	1.61876680
21	INSRR	1.59157867
22	AKT3	1.56329886
23	LMTK2	1.56249244
24	PTK2	1.55390466
25	MUSK	1.48883701
26	FLT3	1.46551081
27	MAPKAPK3	1.44075220
28	SIK3	1.39704373
29	PRPF4B	1.38225024
30	LATS2	1.36575392
31	STK38	1.32706359
32	PAK3	1.30581245
33	PRKD2	1.26377214
34	BMPR1B	1.26253209
35	PKN1	1.21054741
36	ROCK1	1.20775155
37	STK38L	1.17275778
38	TGFBR2	1.15171831
39	EPHB2	1.12407698
40	CDC42BPA	1.11374921
41	MAP3K6	1.09138892
42	PIM2	1.06234279
43	MKNK2	1.05373549
44	TESK1	1.01432355
45	DAPK3	0.98945704
46	ILK	0.97373478
47	TNIK	0.92769928
48	TRPM7	0.92553475
49	CAMK2D	0.91912009
50	PRKCE	0.90820279
51	PDGFRB	0.86377749
52	MET	0.85449886
53	STK4	0.81669332
54	PTK2B	0.81543753
55	YES1	0.80331121
56	EIF2AK2	0.79189733
57	ADRBK2	0.77769808
58	SGK2	0.76871407
59	TRIB3	0.73118083
60	CAMK2A	0.70266899
61	MKNK1	0.69957852
62	PRKD1	0.69870554
63	PRKG1	0.69287543
64	PLK2	0.68577242
65	KIT	0.66291910
66	EPHB1	0.64320555
67	ROCK2	0.64133935
68	MAPK12	0.63919856
69	MTOR	0.63775372
70	MELK	0.63305350
71	MAPK7	0.62186618
72	CDK8	0.62111335
73	BLK	0.60530252
74	CLK1	0.60166672
75	RIPK1	0.59909041
76	GRK1	0.57145874
77	RPS6KA2	0.57134020
78	NTRK1	0.56932237
79	ERBB4	0.56469211
80	PRKACB	0.56255624
81	MAP2K1	0.54995718
82	MARK1	0.54963014
83	CAMK2G	0.54853238
84	BMPR2	0.52587410
85	JAK1	0.52471557
86	PINK1	0.52373702
87	EEF2K	0.52147474
88	TEC	0.51490260
89	STK3	0.50302566
90	CAMK1	0.49825961
91	PAK2	0.48723959
92	TXK	0.48418693
93	PRKACA	0.48060045
94	ERBB3	0.47964510
95	MAPK4	0.47917965
96	ADRBK1	0.47716064
97	SIK1	0.46968444
98	IRAK3	0.46917974
99	PRKAA1	0.46238180
100	MAP3K14	0.46006083
101	NEK6	0.45721000
102	RPS6KC1	0.44925865
103	RPS6KL1	0.44925865
104	PRKAA2	0.44612664
105	MAP2K7	0.44038089
106	SGK1	0.43326856
107	ABL2	0.43318172
108	GSK3A	0.42281079
109	SGK3	0.41208143
110	NLK	0.41119653
111	PRKCQ	0.41009292
112	DDR2	0.39775213
113	PAK6	0.39421325
114	MOS	0.38996591
115	RPS6KA6	0.38578551
116	GRK5	0.38127598
117	SGK223	0.37959030
118	SGK494	0.37959030
119	PAK4	0.36862091
120	MARK3	0.36686922
121	RET	0.35308701
122	CCNB1	0.35280890
123	MAP3K7	0.35228902
124	FER	0.34580388
125	EPHA3	0.33880029
126	ICK	0.33852646
127	NEK9	0.33475204
128	PRKG2	0.32826187
129	RAF1	0.31911982
130	LIMK1	0.31558672
131	PIK3CG	0.30925158
132	CAMK4	0.30374530
133	PDK4	0.28639378
134	PDK3	0.28639378
135	PAK1	0.28634694
136	MAPK13	0.28616393
137	TGFBR1	0.27158506
138	DYRK1B	0.26468564
139	PRKACG	0.26193443
140	PDK2	0.26090333
141	FGFR1	0.25106074
142	IRAK4	0.24289154

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	5.45462914
2	Dilated cardiomyopathy_Homo sapiens_hsa05414	5.16221183
3	Cardiac muscle contraction_Homo sapiens_hsa04260	4.78133600
4	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	3.89470752
5	Viral myocarditis_Homo sapiens_hsa05416	2.21243941
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.13958515
7	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	2.00670372
8	Parkinsons disease_Homo sapiens_hsa05012	1.97923713
9	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.75308494
10	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.73851159
11	ECM-receptor interaction_Homo sapiens_hsa04512	1.67094238
12	Alzheimers disease_Homo sapiens_hsa05010	1.65261980
13	Adherens junction_Homo sapiens_hsa04520	1.58029728
14	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.55472547
15	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.54561665
16	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.45769744
17	Focal adhesion_Homo sapiens_hsa04510	1.43332826
18	Huntingtons disease_Homo sapiens_hsa05016	1.34838253
19	Tight junction_Homo sapiens_hsa04530	1.34456784
20	Axon guidance_Homo sapiens_hsa04360	1.31968964
21	Basal cell carcinoma_Homo sapiens_hsa05217	1.27906984
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.26345984
23	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.23548918
24	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.19338443
25	Calcium signaling pathway_Homo sapiens_hsa04020	1.17466980
26	Circadian entrainment_Homo sapiens_hsa04713	1.16435157
27	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	1.06016472
28	Wnt signaling pathway_Homo sapiens_hsa04310	1.02670595
29	Hippo signaling pathway_Homo sapiens_hsa04390	1.00321509
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.97808456
31	cAMP signaling pathway_Homo sapiens_hsa04024	0.95536525
32	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.91141661
33	Melanoma_Homo sapiens_hsa05218	0.90609143
34	Proteoglycans in cancer_Homo sapiens_hsa05205	0.90564928
35	Morphine addiction_Homo sapiens_hsa05032	0.87000317
36	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.86876822
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86362603
38	Malaria_Homo sapiens_hsa05144	0.85766462
39	Taste transduction_Homo sapiens_hsa04742	0.85359808
40	Fatty acid elongation_Homo sapiens_hsa00062	0.84607398
41	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.84072249
42	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.83931407
43	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.82747738
44	Melanogenesis_Homo sapiens_hsa04916	0.82537776
45	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.82006804
46	Cocaine addiction_Homo sapiens_hsa05030	0.80807364
47	Amoebiasis_Homo sapiens_hsa05146	0.79629750
48	Gastric acid secretion_Homo sapiens_hsa04971	0.78900881
49	PPAR signaling pathway_Homo sapiens_hsa03320	0.78699567
50	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.77953113
51	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.75421415
52	Renin secretion_Homo sapiens_hsa04924	0.74823862
53	Pathways in cancer_Homo sapiens_hsa05200	0.74760270
54	Serotonergic synapse_Homo sapiens_hsa04726	0.74181587
55	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.73870605
56	Platelet activation_Homo sapiens_hsa04611	0.72155404
57	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.71308196
58	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.69047113
59	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68724520
60	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.68506501
61	Rheumatoid arthritis_Homo sapiens_hsa05323	0.68185311
62	Leishmaniasis_Homo sapiens_hsa05140	0.67048931
63	Complement and coagulation cascades_Homo sapiens_hsa04610	0.65572506
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.65517608
65	Circadian rhythm_Homo sapiens_hsa04710	0.63925773
66	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.63751697
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.63147969
68	Propanoate metabolism_Homo sapiens_hsa00640	0.60963735
69	MicroRNAs in cancer_Homo sapiens_hsa05206	0.59515315
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59304424
71	Insulin secretion_Homo sapiens_hsa04911	0.58286512
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56478765
73	Insulin resistance_Homo sapiens_hsa04931	0.55889500
74	Prion diseases_Homo sapiens_hsa05020	0.54764786
75	MAPK signaling pathway_Homo sapiens_hsa04010	0.54114828
76	Glucagon signaling pathway_Homo sapiens_hsa04922	0.53926367
77	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.52939602
78	Pancreatic secretion_Homo sapiens_hsa04972	0.52187567
79	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.52081799
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.51892418
81	Allograft rejection_Homo sapiens_hsa05330	0.51460640
82	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.51156128
83	Salmonella infection_Homo sapiens_hsa05132	0.50430495
84	Rap1 signaling pathway_Homo sapiens_hsa04015	0.50357101
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.49839763
86	Prostate cancer_Homo sapiens_hsa05215	0.49287380
87	Nicotine addiction_Homo sapiens_hsa05033	0.48584952
88	GABAergic synapse_Homo sapiens_hsa04727	0.48207541
89	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.47717759
90	GnRH signaling pathway_Homo sapiens_hsa04912	0.47029291
91	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.45744970
92	Bile secretion_Homo sapiens_hsa04976	0.45686486
93	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.45654364
94	Small cell lung cancer_Homo sapiens_hsa05222	0.45588725
95	Graft-versus-host disease_Homo sapiens_hsa05332	0.45475486
96	FoxO signaling pathway_Homo sapiens_hsa04068	0.45280816
97	Olfactory transduction_Homo sapiens_hsa04740	0.44815873
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.43044764
99	Lysine degradation_Homo sapiens_hsa00310	0.41907237
100	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.41623183
101	Ras signaling pathway_Homo sapiens_hsa04014	0.41524276
102	Toxoplasmosis_Homo sapiens_hsa05145	0.41252817
103	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.40402236
104	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.40364064
105	Insulin signaling pathway_Homo sapiens_hsa04910	0.40027288
106	Mineral absorption_Homo sapiens_hsa04978	0.39756149
107	Salivary secretion_Homo sapiens_hsa04970	0.39070524
108	Bladder cancer_Homo sapiens_hsa05219	0.38565139
109	Cholinergic synapse_Homo sapiens_hsa04725	0.38148405
110	Long-term depression_Homo sapiens_hsa04730	0.36895024
111	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.36844835
112	mTOR signaling pathway_Homo sapiens_hsa04150	0.36480536
113	Renal cell carcinoma_Homo sapiens_hsa05211	0.35887150
114	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.35744050
115	Fanconi anemia pathway_Homo sapiens_hsa03460	0.35699500
116	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.35510609
117	Fatty acid degradation_Homo sapiens_hsa00071	0.35472973
118	AMPK signaling pathway_Homo sapiens_hsa04152	0.35084073
119	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.34961207
120	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.34221563
121	Amphetamine addiction_Homo sapiens_hsa05031	0.32760692
122	Estrogen signaling pathway_Homo sapiens_hsa04915	0.32382668
123	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.32045874
124	HTLV-I infection_Homo sapiens_hsa05166	0.31166678
125	Glutamatergic synapse_Homo sapiens_hsa04724	0.30256052
126	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.29929898
127	Measles_Homo sapiens_hsa05162	0.29460925
128	Sulfur metabolism_Homo sapiens_hsa00920	0.29200621
129	Endometrial cancer_Homo sapiens_hsa05213	0.28250117
130	Protein digestion and absorption_Homo sapiens_hsa04974	0.28084205
131	Notch signaling pathway_Homo sapiens_hsa04330	0.28022078
132	Dopaminergic synapse_Homo sapiens_hsa04728	0.27926680
133	Gap junction_Homo sapiens_hsa04540	0.27081830
134	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.23602034
135	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.23326146
136	Choline metabolism in cancer_Homo sapiens_hsa05231	0.23068298

TBX5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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