TC2N

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.01082944
2axon ensheathment in central nervous system (GO:0032291)7.01082944
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.45739723
4negative regulation of cell killing (GO:0031342)6.45739723
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.31772129
6negative T cell selection (GO:0043383)5.95864792
7positive regulation of gamma-delta T cell activation (GO:0046645)5.91003546
8regulation of gamma-delta T cell differentiation (GO:0045586)5.67039847
9negative thymic T cell selection (GO:0045060)5.44126154
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.14222029
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.13294432
12regulation of gamma-delta T cell activation (GO:0046643)5.05495596
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98445512
14positive T cell selection (GO:0043368)4.91347291
15dopamine transport (GO:0015872)4.88351173
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.83864937
17dopamine biosynthetic process (GO:0042416)4.79606881
18regulation of B cell receptor signaling pathway (GO:0050855)4.71962434
19neuron cell-cell adhesion (GO:0007158)4.71728644
20ATP synthesis coupled proton transport (GO:0015986)4.68306832
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.68306832
22antigen processing and presentation of endogenous antigen (GO:0019883)4.58961635
23long-chain fatty acid biosynthetic process (GO:0042759)4.58531510
24T cell selection (GO:0045058)4.56637634
25fatty acid elongation (GO:0030497)4.50755821
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.49810164
27regulation of regulatory T cell differentiation (GO:0045589)4.48916988
28glycerophospholipid catabolic process (GO:0046475)4.47418359
29thymic T cell selection (GO:0045061)4.41426193
30neuron remodeling (GO:0016322)4.36233798
31T cell migration (GO:0072678)4.30736774
32tolerance induction (GO:0002507)4.29157540
33positive thymic T cell selection (GO:0045059)4.25986350
34negative regulation of neurotransmitter transport (GO:0051589)4.20347047
35cellular response to interleukin-15 (GO:0071350)4.13330390
36positive regulation of tolerance induction (GO:0002645)4.11335239
37response to interleukin-15 (GO:0070672)4.07728003
38regulation of collateral sprouting (GO:0048670)4.05820090
39positive regulation of granulocyte differentiation (GO:0030854)3.95590456
40regulation of catecholamine metabolic process (GO:0042069)3.83134212
41regulation of dopamine metabolic process (GO:0042053)3.83134212
42presynaptic membrane assembly (GO:0097105)3.82783622
43negative regulation of T cell mediated immunity (GO:0002710)3.82490046
44negative regulation of lymphocyte mediated immunity (GO:0002707)3.79068223
45respiratory electron transport chain (GO:0022904)3.78915170
46leukocyte aggregation (GO:0070486)3.78416800
47protein neddylation (GO:0045116)3.78377039
48regulation of alpha-beta T cell proliferation (GO:0046640)3.76705426
49presynaptic membrane organization (GO:0097090)3.75940209
50transmission of nerve impulse (GO:0019226)3.75137020
51hepatocyte apoptotic process (GO:0097284)3.72307182
52electron transport chain (GO:0022900)3.69067451
53myelination (GO:0042552)3.68790122
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.66744348
55regulation of tolerance induction (GO:0002643)3.66689782
56ensheathment of neurons (GO:0007272)3.61543626
57axon ensheathment (GO:0008366)3.61543626
58positive regulation of alpha-beta T cell proliferation (GO:0046641)3.61359958
59regulation of glutamate secretion (GO:0014048)3.59577505
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.57652791
61regulation of T cell tolerance induction (GO:0002664)3.56156220
62negative regulation of stress fiber assembly (GO:0051497)3.55985186
63oligodendrocyte differentiation (GO:0048709)3.54851330
64antigen processing and presentation via MHC class Ib (GO:0002475)3.54142352
65T cell receptor signaling pathway (GO:0050852)3.53273034
66limb bud formation (GO:0060174)3.48428674
67regulation of T cell mediated cytotoxicity (GO:0001914)3.45426284
68dendritic cell chemotaxis (GO:0002407)3.42621567
69positive regulation of gastrulation (GO:2000543)3.36224558
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.28359022
71antigen receptor-mediated signaling pathway (GO:0050851)3.26537048
72dendritic cell migration (GO:0036336)3.26379742
73catechol-containing compound biosynthetic process (GO:0009713)3.26074985
74catecholamine biosynthetic process (GO:0042423)3.26074985
75cell proliferation in forebrain (GO:0021846)3.25828405
76positive regulation of T cell mediated cytotoxicity (GO:0001916)3.23359746
77regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.23289590
78regulation of natural killer cell mediated immunity (GO:0002715)3.23289590
79regulation of isotype switching to IgG isotypes (GO:0048302)3.21967769
80negative regulation of leukocyte mediated immunity (GO:0002704)3.21751141
81catecholamine transport (GO:0051937)3.20975751
82positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.20874594
83regulation of leukocyte mediated cytotoxicity (GO:0001910)3.19509626
84negative regulation of axon extension involved in axon guidance (GO:0048843)3.14555977
85cell fate commitment involved in formation of primary germ layer (GO:0060795)3.14279208
86interferon-gamma secretion (GO:0072643)3.14080204
87neuron recognition (GO:0008038)3.13697681
88positive regulation of synapse assembly (GO:0051965)3.11204716
89histone H3-K36 demethylation (GO:0070544)3.10247646
90negative regulation of neurotransmitter secretion (GO:0046929)3.10105225
91negative regulation of axon guidance (GO:1902668)3.09414729
92neutrophil activation involved in immune response (GO:0002283)3.08823921
93negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.08615512
94cholesterol biosynthetic process (GO:0006695)3.06393749
95phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.05430157
96positive regulation of natural killer cell mediated immunity (GO:0002717)3.05224764
97activated T cell proliferation (GO:0050798)3.03754749
98positive regulation of interleukin-4 production (GO:0032753)3.02989711
99alpha-beta T cell differentiation (GO:0046632)3.02463409
100interferon-gamma production (GO:0032609)3.01807696
101negative regulation of axon extension (GO:0030517)3.01006187
102negative regulation of protein localization to cell surface (GO:2000009)3.00370028
103negative regulation of adaptive immune response (GO:0002820)2.99798719
104mating behavior (GO:0007617)2.99108870
105neuronal action potential propagation (GO:0019227)2.98262587
106negative regulation of T cell apoptotic process (GO:0070233)2.98249442
107positive regulation of humoral immune response (GO:0002922)2.97776262
108phenol-containing compound catabolic process (GO:0019336)2.96911840
109regulation of B cell differentiation (GO:0045577)2.96821737
110B cell receptor signaling pathway (GO:0050853)2.96670925
111regulation of vesicle fusion (GO:0031338)2.95950752
112cilium or flagellum-dependent cell motility (GO:0001539)2.94383988
113enteric nervous system development (GO:0048484)2.94279968
114substantia nigra development (GO:0021762)2.92797185
115CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.90304853
116T-helper cell differentiation (GO:0042093)2.90304853
117ribosomal small subunit biogenesis (GO:0042274)2.89690109
118nucleoside diphosphate catabolic process (GO:0009134)2.89656337
119short-term memory (GO:0007614)2.89442846
120regulation of pigment cell differentiation (GO:0050932)2.89140627
121positive regulation of cell killing (GO:0031343)2.88862784
122positive regulation of cell fate commitment (GO:0010455)2.87084148
123gamma-aminobutyric acid signaling pathway (GO:0007214)2.86795495
124negative regulation of glycoprotein biosynthetic process (GO:0010561)2.86490243
125regulation of defense response to virus by virus (GO:0050690)2.85390794
126lymph node development (GO:0048535)2.84997584
127alpha-beta T cell activation (GO:0046631)2.84969021
128neurotransmitter catabolic process (GO:0042135)2.84569475
129regulation of cell killing (GO:0031341)2.83538487
130parturition (GO:0007567)2.82526928
131neutrophil activation (GO:0042119)2.82150482
132lymphocyte migration (GO:0072676)2.81961769
133regulation of feeding behavior (GO:0060259)2.81698684
134T cell costimulation (GO:0031295)2.76521628
135regulation of T cell receptor signaling pathway (GO:0050856)2.75133452
136polyol transport (GO:0015791)2.74866101
137L-amino acid import (GO:0043092)2.74277646
138otic vesicle formation (GO:0030916)2.73332626
139lymphocyte costimulation (GO:0031294)2.72935700
140dendritic spine morphogenesis (GO:0060997)2.72015711
141establishment of protein localization to mitochondrial membrane (GO:0090151)2.71517581
142signal complex assembly (GO:0007172)2.71192548
143detection of other organism (GO:0098543)2.70368112
144positive regulation of isotype switching (GO:0045830)2.69590138
145lateral sprouting from an epithelium (GO:0060601)2.69444658
146negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.68312865
147regulation of interleukin-4 production (GO:0032673)2.67573207
148synaptic transmission, dopaminergic (GO:0001963)2.67168430
149response to type I interferon (GO:0034340)2.66479216
150vocalization behavior (GO:0071625)2.66251754
151detection of bacterium (GO:0016045)2.64828014
152type I interferon signaling pathway (GO:0060337)2.64756732
153cellular response to type I interferon (GO:0071357)2.64756732
154regulation of interleukin-2 biosynthetic process (GO:0045076)2.64746869
155behavioral response to cocaine (GO:0048148)2.64549621
156retina layer formation (GO:0010842)2.64300067
157chaperone-mediated protein transport (GO:0072321)2.64038094
158positive regulation of B cell differentiation (GO:0045579)2.63431479
159hydrogen ion transmembrane transport (GO:1902600)2.63315983
160positive regulation of interleukin-2 production (GO:0032743)2.62815632
161neurotransmitter uptake (GO:0001504)2.62332115
162G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.60742311
163peripheral nervous system development (GO:0007422)2.59877070
164positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.59376053
165positive regulation of macrophage differentiation (GO:0045651)2.59180657
166T cell mediated immunity (GO:0002456)2.58939232
167mast cell activation (GO:0045576)2.58871200
168cellular response to epinephrine stimulus (GO:0071872)2.58455984
169T cell differentiation involved in immune response (GO:0002292)2.57359524
170alpha-beta T cell differentiation involved in immune response (GO:0002293)2.57359524
171alpha-beta T cell activation involved in immune response (GO:0002287)2.57359524
172T cell differentiation (GO:0030217)2.57149143
173isoprenoid biosynthetic process (GO:0008299)2.57001599
174sterol biosynthetic process (GO:0016126)2.56887740
175photoreceptor cell differentiation (GO:0046530)2.56529321
176eye photoreceptor cell differentiation (GO:0001754)2.56529321
177spinal cord association neuron differentiation (GO:0021527)2.56172181
178regulation of T cell mediated immunity (GO:0002709)2.55253424
179opioid receptor signaling pathway (GO:0038003)2.55123579
180response to cocaine (GO:0042220)2.54822472
181positive regulation of neurological system process (GO:0031646)2.53227886
182glutamate receptor signaling pathway (GO:0007215)2.53121110
183positive regulation of amino acid transport (GO:0051957)2.52041351
184response to epinephrine (GO:0071871)2.52032764
185keratinocyte development (GO:0003334)2.51874577
186nucleotide transmembrane transport (GO:1901679)2.51649412
187GTP biosynthetic process (GO:0006183)2.51532616
188regulation of transmission of nerve impulse (GO:0051969)2.48789657
189forebrain neuron development (GO:0021884)2.47198848
190alkaloid metabolic process (GO:0009820)2.45158262
191negative regulation of amino acid transport (GO:0051956)2.44596681
192proton transport (GO:0015992)2.43386014
193adult walking behavior (GO:0007628)2.42934051
194positive regulation of action potential (GO:0045760)2.42876721
195G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41437723
196cranial nerve development (GO:0021545)2.41271257
197axonal fasciculation (GO:0007413)2.38379833
198positive regulation of cellular amine metabolic process (GO:0033240)2.38310270
199hydrogen transport (GO:0006818)2.38150826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.25853351
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.66873088
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.36559887
4EZH2_22144423_ChIP-Seq_EOC_Human3.87287779
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.59521577
6RUNX_20019798_ChIP-Seq_JUKART_Human3.47619876
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.46731727
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.32843319
9GBX2_23144817_ChIP-Seq_PC3_Human2.98310964
10TAF15_26573619_Chip-Seq_HEK293_Human2.94611986
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.80143750
12MYB_26560356_Chip-Seq_TH2_Human2.76391047
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69252344
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.66981192
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64951881
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62260643
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.58228435
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.57102688
19VDR_22108803_ChIP-Seq_LS180_Human2.56597314
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50535868
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.49219540
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.48064372
23* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.43970230
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.40074380
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37892329
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33576917
27MYB_26560356_Chip-Seq_TH1_Human2.33195676
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33166829
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30428216
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26965339
31JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25649496
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23686599
33CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23298454
34CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20287627
35SCL_19346495_ChIP-Seq_HPC-7_Human2.20253744
36CBX2_27304074_Chip-Seq_ESCs_Mouse2.18973692
37IRF8_27001747_Chip-Seq_BMDM_Mouse2.15297013
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11736922
39RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07538263
40EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07538263
41GATA3_27048872_Chip-Seq_THYMUS_Human2.02072912
42FUS_26573619_Chip-Seq_HEK293_Human1.99675834
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97877170
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95991482
45AR_21572438_ChIP-Seq_LNCaP_Human1.94598868
46MAF_26560356_Chip-Seq_TH1_Human1.92881183
47* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92332922
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.91805014
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91413657
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90300301
51P300_19829295_ChIP-Seq_ESCs_Human1.89954841
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.88497418
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85976166
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85903097
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85353791
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.83228145
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.82025202
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.80129647
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79283923
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76811090
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74977438
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.72872422
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72850309
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72430139
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70515251
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70136336
67UTX_26944678_Chip-Seq_JUKART_Human1.67406584
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62299176
69ER_23166858_ChIP-Seq_MCF-7_Human1.61083670
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.60930231
71* RNF2_27304074_Chip-Seq_NSC_Mouse1.60820420
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.60336516
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60076712
74GATA3_26560356_Chip-Seq_TH2_Human1.59054253
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57786003
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57590217
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57540528
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.55823927
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55140686
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54549642
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.54298211
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53088301
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51863124
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51076586
85SPI1_23127762_ChIP-Seq_K562_Human1.49976695
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46114437
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45777345
88ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44754438
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42526977
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.42103046
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.41994996
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.41816502
93IGF1R_20145208_ChIP-Seq_DFB_Human1.41287101
94REST_21632747_ChIP-Seq_MESCs_Mouse1.40940822
95EWS_26573619_Chip-Seq_HEK293_Human1.40932441
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40087157
97SPI1_23547873_ChIP-Seq_NB4_Human1.40066111
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38142520
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37787855
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36646220
101TCF7_22412390_ChIP-Seq_EML_Mouse1.34834799
102SMAD4_21799915_ChIP-Seq_A2780_Human1.32321544
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31365278
104FLI1_27457419_Chip-Seq_LIVER_Mouse1.31005218
105WT1_19549856_ChIP-ChIP_CCG9911_Human1.30556061
106GATA1_19941826_ChIP-Seq_K562_Human1.29276046
107GATA1_22025678_ChIP-Seq_K562_Human1.28905823
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28777432
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27765821
110DROSHA_22980978_ChIP-Seq_HELA_Human1.27541671
111GATA2_19941826_ChIP-Seq_K562_Human1.26523890
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25460622
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.24539444
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24126289
115ZNF274_21170338_ChIP-Seq_K562_Hela1.23145106
116TP53_18474530_ChIP-ChIP_U2OS_Human1.22879810
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22313541
118* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22216346
119PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21411203
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20862069
121P53_22387025_ChIP-Seq_ESCs_Mouse1.20425432
122PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20223965
123GATA1_19941827_ChIP-Seq_MEL_Mouse1.20078094
124SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19962055
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18172705
126STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17612894
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.17599259
128P300_18555785_Chip-Seq_ESCs_Mouse1.17018335
129TAL1_26923725_Chip-Seq_HPCs_Mouse1.16442426
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16137921
131AHR_22903824_ChIP-Seq_MCF-7_Human1.15763704
132MAF_26560356_Chip-Seq_TH2_Human1.15564266
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15458122
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15095427
135* RUNX2_22187159_ChIP-Seq_PCA_Human1.15041602
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13991370
137SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13982933
138HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11966865
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11866116
140HTT_18923047_ChIP-ChIP_STHdh_Human1.11839842
141SOX2_20726797_ChIP-Seq_SW620_Human1.11827233
142RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11735910
143TP63_17297297_ChIP-ChIP_HaCaT_Human1.11403681
144RUNX1_27514584_Chip-Seq_MCF-7_Human1.11398572
145PU_27001747_Chip-Seq_BMDM_Mouse1.10625150
146* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09188541
147GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08827637
148POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08535376
149TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08535376
150EZH2_27294783_Chip-Seq_NPCs_Mouse1.08522386
151GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08227593
152STAT3_18555785_Chip-Seq_ESCs_Mouse1.07762762
153* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06755383
154GATA6_25053715_ChIP-Seq_YYC3_Human1.05916347
155ARNT_22903824_ChIP-Seq_MCF-7_Human1.05904349
156SOX2_18555785_Chip-Seq_ESCs_Mouse1.05364798
157TP53_16413492_ChIP-PET_HCT116_Human1.04908542
158ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04707911
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04701252
160VDR_24763502_ChIP-Seq_THP-1_Human1.03746260
161* GATA4_25053715_ChIP-Seq_YYC3_Human1.03667126
162RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03395314
163OCT4_18555785_Chip-Seq_ESCs_Mouse1.03209260
164* PRDM14_20953172_ChIP-Seq_ESCs_Human1.01467813
165NFE2_27457419_Chip-Seq_LIVER_Mouse1.01049419
166TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99733151
167CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99565076
168KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99190768
169CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99143439
170VDR_24787735_ChIP-Seq_THP-1_Human0.99085324
171NMYC_18555785_Chip-Seq_ESCs_Mouse0.98751587
172SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98682186
173KDM2B_26808549_Chip-Seq_REH_Human0.98489267
174RING1B_27294783_Chip-Seq_ESCs_Mouse0.97752307
175TRIM28_21343339_ChIP-Seq_HEK293_Human0.97585358
176FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97384696
177* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96977057
178AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95264686
179KLF4_18555785_Chip-Seq_ESCs_Mouse0.95004708
180TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94620557
181GATA3_24758297_ChIP-Seq_MCF-7_Human0.94450973
182TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94398034
183SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94308364
184SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94308364
185SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91979882
186GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91805417
187MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89722250
188LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89241280
189LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87565994
190MYC_22102868_ChIP-Seq_BL_Human0.86251460
191FOXA1_25552417_ChIP-Seq_VCAP_Human0.86066580
192GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85114436
193SMRT_27268052_Chip-Seq_Bcells_Human0.82817795
194TP63_23658742_ChIP-Seq_EP156T_Human0.82458141
195KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81615135
196KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81615135
197KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81615135
198PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80666476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.51810614
2MP0003763_abnormal_thymus_physiology4.23349381
3MP0003724_increased_susceptibility_to3.63512711
4MP0005171_absent_coat_pigmentation3.49267338
5MP0009379_abnormal_foot_pigmentation3.28552606
6MP0005671_abnormal_response_to3.21023341
7MP0005423_abnormal_somatic_nervous3.11822249
8MP0001529_abnormal_vocalization2.94846356
9MP0006276_abnormal_autonomic_nervous2.91827909
10MP0005409_darkened_coat_color2.89523492
11MP0001905_abnormal_dopamine_level2.88110394
12MP0002166_altered_tumor_susceptibility2.80301321
13MP0001835_abnormal_antigen_presentation2.78073481
14MP0003300_gastrointestinal_ulcer2.77916945
15MP0002009_preneoplasia2.74448035
16MP0003436_decreased_susceptibility_to2.72906217
17MP0000566_synostosis2.65791227
18MP0001800_abnormal_humoral_immune2.56942964
19MP0010155_abnormal_intestine_physiology2.51291743
20MP0003866_abnormal_defecation2.50988475
21MP0005464_abnormal_platelet_physiology2.36849323
22MP0001873_stomach_inflammation2.36770259
23MP0000465_gastrointestinal_hemorrhage2.34952905
24MP0005000_abnormal_immune_tolerance2.30323845
25MP0003136_yellow_coat_color2.29958206
26MP0000920_abnormal_myelination2.22684471
27MP0004264_abnormal_extraembryonic_tissu2.19706463
28MP0004381_abnormal_hair_follicle2.18390824
29MP0002272_abnormal_nervous_system2.17783957
30MP0002064_seizures2.17027528
31MP0009745_abnormal_behavioral_response2.16063452
32MP0009333_abnormal_splenocyte_physiolog2.15613663
33MP0004947_skin_inflammation2.13807950
34MP0001486_abnormal_startle_reflex2.11707930
35MP0002420_abnormal_adaptive_immunity2.09942384
36MP0004270_analgesia2.09906428
37MP0005025_abnormal_response_to2.09416412
38MP0002723_abnormal_immune_serum2.07447463
39MP0009046_muscle_twitch2.07378154
40MP0001819_abnormal_immune_cell2.07368918
41MP0003635_abnormal_synaptic_transmissio2.05359805
42MP0009785_altered_susceptibility_to2.05032771
43MP0008004_abnormal_stomach_pH2.04160521
44MP0004742_abnormal_vestibular_system2.01780996
45MP0002452_abnormal_antigen_presenting1.98190161
46MP0010234_abnormal_vibrissa_follicle1.97938978
47MP0005387_immune_system_phenotype1.95378933
48MP0001790_abnormal_immune_system1.95378933
49MP0000778_abnormal_nervous_system1.94978329
50MP0001188_hyperpigmentation1.92938429
51MP0002398_abnormal_bone_marrow1.89546055
52MP0001968_abnormal_touch/_nociception1.86211990
53MP0000703_abnormal_thymus_morphology1.86056558
54MP0002572_abnormal_emotion/affect_behav1.84295866
55MP0002006_tumorigenesis1.81336869
56MP0004142_abnormal_muscle_tone1.77304922
57MP0001440_abnormal_grooming_behavior1.77214635
58MP0000685_abnormal_immune_system1.77167015
59MP0001485_abnormal_pinna_reflex1.75128993
60MP0002405_respiratory_system_inflammati1.75092488
61MP0002419_abnormal_innate_immunity1.74019742
62MP0001851_eye_inflammation1.69454806
63MP0002148_abnormal_hypersensitivity_rea1.68864166
64MP0000716_abnormal_immune_system1.67966179
65MP0001666_abnormal_nutrient_absorption1.66755256
66MP0001346_abnormal_lacrimal_gland1.66185491
67MP0005310_abnormal_salivary_gland1.66078106
68MP0002734_abnormal_mechanical_nocicepti1.62967931
69MP0000462_abnormal_digestive_system1.59564547
70MP0001501_abnormal_sleep_pattern1.58171615
71MP0002796_impaired_skin_barrier1.57033440
72MP0000762_abnormal_tongue_morphology1.56738211
73MP0002063_abnormal_learning/memory/cond1.55639485
74MP0000689_abnormal_spleen_morphology1.54265584
75MP0003183_abnormal_peptide_metabolism1.53487945
76MP0005645_abnormal_hypothalamus_physiol1.52495053
77MP0001845_abnormal_inflammatory_respons1.51940879
78MP0002722_abnormal_immune_system1.50935657
79MP0005408_hypopigmentation1.50829162
80MP0002132_abnormal_respiratory_system1.50189569
81MP0004859_abnormal_synaptic_plasticity1.41996290
82MP0001664_abnormal_digestion1.41927443
83MP0002557_abnormal_social/conspecific_i1.41089667
84MP0002102_abnormal_ear_morphology1.40748189
85MP0002736_abnormal_nociception_after1.40271741
86MP0002751_abnormal_autonomic_nervous1.39696431
87MP0003690_abnormal_glial_cell1.39193729
88MP0005379_endocrine/exocrine_gland_phen1.37723239
89MP0000858_altered_metastatic_potential1.37474885
90MP0001533_abnormal_skeleton_physiology1.37013728
91MP0002067_abnormal_sensory_capabilities1.35718922
92MP0005551_abnormal_eye_electrophysiolog1.35293582
93MP0002184_abnormal_innervation1.33468931
94MP0006082_CNS_inflammation1.31656600
95MP0002429_abnormal_blood_cell1.31029255
96MP0001765_abnormal_ion_homeostasis1.30879770
97MP0005083_abnormal_biliary_tract1.29527235
98MP0003303_peritoneal_inflammation1.29174375
99MP0000631_abnormal_neuroendocrine_gland1.26512699
100MP0004883_abnormal_blood_vessel1.26447128
101MP0002638_abnormal_pupillary_reflex1.26402380
102MP0002735_abnormal_chemical_nociception1.25738493
103MP0002277_abnormal_respiratory_mucosa1.22207182
104MP0006292_abnormal_olfactory_placode1.22131097
105MP0003045_fibrosis1.21901024
106MP0002938_white_spotting1.21832317
107MP0004885_abnormal_endolymph1.21451046
108MP0005386_behavior/neurological_phenoty1.18992181
109MP0004924_abnormal_behavior1.18992181
110MP0001986_abnormal_taste_sensitivity1.18942574
111MP0001970_abnormal_pain_threshold1.17005311
112MP0003191_abnormal_cellular_cholesterol1.16969200
113MP0003329_amyloid_beta_deposits1.16309018
114MP0001963_abnormal_hearing_physiology1.14854607
115MP0003828_pulmonary_edema1.13375068
116MP0002882_abnormal_neuron_morphology1.12687372
117MP0000026_abnormal_inner_ear1.11387237
118MP0003122_maternal_imprinting1.11303048
119MP0001177_atelectasis1.11142456
120MP0003938_abnormal_ear_development1.10128505
121MP0003632_abnormal_nervous_system1.09521094
122MP0002733_abnormal_thermal_nociception1.07810155
123MP0002752_abnormal_somatic_nervous1.07210111
124MP0003448_altered_tumor_morphology1.06690822
125MP0003634_abnormal_glial_cell1.05805414
126MP0000627_abnormal_mammary_gland1.05795363
127MP0005410_abnormal_fertilization1.02779352
128MP0002998_abnormal_bone_remodeling1.02692307
129MP0002066_abnormal_motor_capabilities/c1.01171755
130MP0003937_abnormal_limbs/digits/tail_de0.99767440
131MP0002234_abnormal_pharynx_morphology0.99149250
132MP0006072_abnormal_retinal_apoptosis0.98804139
133MP0003453_abnormal_keratinocyte_physiol0.98011316
134MP0000955_abnormal_spinal_cord0.97796574
135MP0004145_abnormal_muscle_electrophysio0.96821444
136MP0010352_gastrointestinal_tract_polyps0.96216844
137MP0003656_abnormal_erythrocyte_physiolo0.95175783
138MP0008260_abnormal_autophagy0.94732939
139MP0008469_abnormal_protein_level0.94230012
140MP0008057_abnormal_DNA_replication0.94055982
141MP0008789_abnormal_olfactory_epithelium0.92627504
142MP0010386_abnormal_urinary_bladder0.92579718
143MP0010678_abnormal_skin_adnexa0.91412581
144MP0004130_abnormal_muscle_cell0.91108219
145MP0003091_abnormal_cell_migration0.90727445
146MP0005253_abnormal_eye_physiology0.89847261
147MP0002229_neurodegeneration0.89535066
148MP0005646_abnormal_pituitary_gland0.89488116
149MP0002295_abnormal_pulmonary_circulatio0.89152689
150MP0000613_abnormal_salivary_gland0.87583111
151MP0000490_abnormal_crypts_of0.86722986
152MP0001502_abnormal_circadian_rhythm0.86599558
153MP0002876_abnormal_thyroid_physiology0.85473013
154MP0009763_increased_sensitivity_to0.84928395
155MP0005164_abnormal_response_to0.84862000
156MP0002163_abnormal_gland_morphology0.84231613
157MP0008569_lethality_at_weaning0.83308990
158MP0002396_abnormal_hematopoietic_system0.83212620
159MP0001853_heart_inflammation0.81577927
160MP0004134_abnormal_chest_morphology0.81503309
161MP0005075_abnormal_melanosome_morpholog0.81292442
162MP0005365_abnormal_bile_salt0.81167695
163MP0004782_abnormal_surfactant_physiolog0.81080038
164MP0001984_abnormal_olfaction0.80708377
165MP0005166_decreased_susceptibility_to0.80708230
166MP0003868_abnormal_feces_composition0.80456458
167MP0001663_abnormal_digestive_system0.79652983
168MP0001727_abnormal_embryo_implantation0.79462708
169MP0002136_abnormal_kidney_physiology0.78871091
170MP0005623_abnormal_meninges_morphology0.78795012
171MP0001216_abnormal_epidermal_layer0.77389378
172MP0003631_nervous_system_phenotype0.77008486
173MP0002822_catalepsy0.76824305
174MP0005394_taste/olfaction_phenotype0.76279685
175MP0005499_abnormal_olfactory_system0.76279685
176MP0001881_abnormal_mammary_gland0.76084134
177MP0005085_abnormal_gallbladder_physiolo0.75640401
178MP0005195_abnormal_posterior_eye0.75638270
179MP0009250_abnormal_appendicular_skeleto0.75541189
180MP0002254_reproductive_system_inflammat0.75399647
181MP0002933_joint_inflammation0.75202590
182MP0000538_abnormal_urinary_bladder0.75114441
183MP0000249_abnormal_blood_vessel0.73275579
184MP0001919_abnormal_reproductive_system0.73264129
185MP0009643_abnormal_urine_homeostasis0.73221458
186MP0002019_abnormal_tumor_incidence0.72659918
187MP0002138_abnormal_hepatobiliary_system0.72298884
188MP0003252_abnormal_bile_duct0.72278004
189MP0003566_abnormal_cell_adhesion0.71475838
190MP0000383_abnormal_hair_follicle0.69379009
191MP0004484_altered_response_of0.67984431
192MP0000377_abnormal_hair_follicle0.67961683
193MP0000477_abnormal_intestine_morphology0.67741098
194MP0002168_other_aberrant_phenotype0.66189743

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.97783153
2Abnormality of T cell number (HP:0011839)5.51897241
3Eczematoid dermatitis (HP:0000976)4.95964139
4Focal motor seizures (HP:0011153)4.40483073
5Autoimmune hemolytic anemia (HP:0001890)4.21693709
6Limb dystonia (HP:0002451)4.04736931
7Acute necrotizing encephalopathy (HP:0006965)4.03161268
8Parakeratosis (HP:0001036)3.96802045
9Elevated erythrocyte sedimentation rate (HP:0003565)3.89481980
10Prolonged bleeding time (HP:0003010)3.88992253
11Stomatitis (HP:0010280)3.79319463
12Abnormality of T cells (HP:0002843)3.76343751
13Recurrent bronchitis (HP:0002837)3.71133774
14Bronchiectasis (HP:0002110)3.70272502
15Recurrent bacterial skin infections (HP:0005406)3.64960066
16Degeneration of the lateral corticospinal tracts (HP:0002314)3.64812490
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.64812490
18Bronchitis (HP:0012387)3.55538413
19Progressive macrocephaly (HP:0004481)3.51045196
20Sensory axonal neuropathy (HP:0003390)3.44386766
21Abnormality of incisor morphology (HP:0011063)3.44343090
22Spontaneous hematomas (HP:0007420)3.43231240
23Recurrent abscess formation (HP:0002722)3.37958418
24Myositis (HP:0100614)3.36001481
25Chronic bronchitis (HP:0004469)3.32854253
26Neurofibrillary tangles (HP:0002185)3.28737200
27Alacrima (HP:0000522)3.28365230
28Abnormal mitochondria in muscle tissue (HP:0008316)3.18408644
29Pustule (HP:0200039)3.17348393
30Peripheral hypomyelination (HP:0007182)3.17071633
31Hyperactive renin-angiotensin system (HP:0000841)3.16510591
32Hypothermia (HP:0002045)3.13935072
33Acute encephalopathy (HP:0006846)3.13259144
34Chronic diarrhea (HP:0002028)3.09600217
35Nasal polyposis (HP:0100582)3.07982124
36Abnormality of the axillary hair (HP:0100134)3.07625998
37Abnormality of secondary sexual hair (HP:0009888)3.07625998
38Rhinitis (HP:0012384)3.06056407
39White forelock (HP:0002211)3.01583081
40Patchy hypopigmentation of hair (HP:0011365)2.97252164
41Decreased lacrimation (HP:0000633)2.96811890
42Aplasia cutis congenita (HP:0001057)2.96388128
433-Methylglutaconic aciduria (HP:0003535)2.94340716
44Gingival bleeding (HP:0000225)2.94155061
45Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.93276768
46Epistaxis (HP:0000421)2.91648698
47Mitochondrial inheritance (HP:0001427)2.90617279
48Gastrointestinal infarctions (HP:0005244)2.90060051
49Abnormality of macrophages (HP:0004311)2.87931775
50Recurrent fungal infections (HP:0002841)2.84943924
51Leukodystrophy (HP:0002415)2.83300805
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.81748789
53Renal Fanconi syndrome (HP:0001994)2.81633298
54Cerebral inclusion bodies (HP:0100314)2.81058096
55Inflammation of the large intestine (HP:0002037)2.80689760
56Retrobulbar optic neuritis (HP:0100654)2.80006192
57Optic neuritis (HP:0100653)2.80006192
58Optic disc pallor (HP:0000543)2.76479295
59Atonic seizures (HP:0010819)2.75969833
60Lip pit (HP:0100267)2.75128077
61Absent/shortened dynein arms (HP:0200106)2.72527041
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.72527041
63Abnormal platelet volume (HP:0011876)2.71894334
64Encephalitis (HP:0002383)2.70074512
65Orchitis (HP:0100796)2.70023271
66Petechiae (HP:0000967)2.68614136
67Focal seizures (HP:0007359)2.66616086
68Abnormal pupillary function (HP:0007686)2.66144270
69Severe combined immunodeficiency (HP:0004430)2.65099996
70Abnormality of the corticospinal tract (HP:0002492)2.64646457
71Gastrointestinal inflammation (HP:0004386)2.64154726
72IgG deficiency (HP:0004315)2.58146849
73Recurrent viral infections (HP:0004429)2.56139508
74Increased mean platelet volume (HP:0011877)2.51758722
75Abnormality of eosinophils (HP:0001879)2.51375355
76Leukocytosis (HP:0001974)2.51344750
77Vasculitis (HP:0002633)2.49768982
78Abnormality of the fingertips (HP:0001211)2.48843694
79IgM deficiency (HP:0002850)2.47816717
80Menorrhagia (HP:0000132)2.47466351
81Septate vagina (HP:0001153)2.46463670
82Colitis (HP:0002583)2.45916059
83Joint swelling (HP:0001386)2.45483815
84Purpura (HP:0000979)2.45196618
85Increased IgE level (HP:0003212)2.44901931
86Abnormal ciliary motility (HP:0012262)2.44724396
87Abnormality of the nasal mucosa (HP:0000433)2.44032039
88Morphological abnormality of the inner ear (HP:0011390)2.42554533
89Recurrent skin infections (HP:0001581)2.42082460
90Recurrent otitis media (HP:0000403)2.42054480
91Meningitis (HP:0001287)2.41088715
92Gingivitis (HP:0000230)2.40973283
93Conical tooth (HP:0000698)2.38979542
94Stenosis of the external auditory canal (HP:0000402)2.38436577
95Eosinophilia (HP:0001880)2.37287633
96Hypoplastic pelvis (HP:0008839)2.36455952
97Recurrent sinusitis (HP:0011108)2.34765157
98Aplasia involving bones of the upper limbs (HP:0009823)2.32750930
99Aplasia of the phalanges of the hand (HP:0009802)2.32750930
100Aplasia involving bones of the extremities (HP:0009825)2.32750930
101Increased IgM level (HP:0003496)2.32705689
102Vaginal atresia (HP:0000148)2.32552464
103Neoplasm of the tracheobronchial system (HP:0100552)2.32055122
104Retinal dysplasia (HP:0007973)2.31552271
105Chronic sinusitis (HP:0011109)2.30601428
106Abnormality of the parathyroid morphology (HP:0011766)2.30038975
107Abnormality of T cell physiology (HP:0011840)2.28861389
108Stomach cancer (HP:0012126)2.28785750
109Granulocytopenia (HP:0001913)2.28620458
110Chronic otitis media (HP:0000389)2.27765162
111Hypoplastic nipples (HP:0002557)2.26954841
112Hypoplasia of the iris (HP:0007676)2.26165109
113Genital tract atresia (HP:0001827)2.25532408
114Increased hepatocellular lipid droplets (HP:0006565)2.25048684
115Glucose intolerance (HP:0000833)2.24431253
116Severe visual impairment (HP:0001141)2.23543386
117Hypoproteinemia (HP:0003075)2.22685920
118Absence seizures (HP:0002121)2.22546280
119Dialeptic seizures (HP:0011146)2.21931449
120Slow saccadic eye movements (HP:0000514)2.21140979
121Alveolar cell carcinoma (HP:0006519)2.19810067
122Panhypogammaglobulinemia (HP:0003139)2.19519581
123Keratoconjunctivitis sicca (HP:0001097)2.19101031
124Arterial thrombosis (HP:0004420)2.18870011
125Congenital sensorineural hearing impairment (HP:0008527)2.17559799
126Congenital ichthyosiform erythroderma (HP:0007431)2.17279627
127Split foot (HP:0001839)2.16692349
128Chest pain (HP:0100749)2.16448387
129Increased CSF lactate (HP:0002490)2.15905197
130Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.15389867
131Septo-optic dysplasia (HP:0100842)2.13807981
132Interstitial pulmonary disease (HP:0006530)2.12771018
133Malnutrition (HP:0004395)2.12769018
134Myokymia (HP:0002411)2.12200410
135Visual hallucinations (HP:0002367)2.12106976
136Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12079770
137X-linked dominant inheritance (HP:0001423)2.11837075
138Pulmonary infiltrates (HP:0002113)2.11504725
139Aplasia/Hypoplasia of the tibia (HP:0005772)2.11357413
140Decreased circulating renin level (HP:0003351)2.11038674
141Recurrent gram-negative bacterial infections (HP:0005420)2.10591317
142Synostosis involving the elbow (HP:0003938)2.09023302
143Humeroradial synostosis (HP:0003041)2.09023302
144Gait imbalance (HP:0002141)2.08690533
145Chronic mucocutaneous candidiasis (HP:0002728)2.08212807
146Recurrent cutaneous fungal infections (HP:0011370)2.08212807
147Lymphopenia (HP:0001888)2.07943847
148Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.07927821
149Abnormal respiratory motile cilium morphology (HP:0005938)2.07759844
150Abnormal respiratory epithelium morphology (HP:0012253)2.07759844
151Papilledema (HP:0001085)2.07237390
152Mediastinal lymphadenopathy (HP:0100721)2.03920905
153Abnormality of cells of the lymphoid lineage (HP:0012140)2.03103171
154Medial flaring of the eyebrow (HP:0010747)2.01546334
155Thyroiditis (HP:0100646)2.01425749
156Abnormal glucose tolerance (HP:0001952)2.00987492
157Hyperventilation (HP:0002883)2.00785028
158Infertility (HP:0000789)2.00407903
159Abnormality of renal resorption (HP:0011038)1.99041091
160Obstructive lung disease (HP:0006536)1.98501573
161Chronic obstructive pulmonary disease (HP:0006510)1.98501573
162Keratoconjunctivitis (HP:0001096)1.98349909
163Combined immunodeficiency (HP:0005387)1.96103086
164Broad-based gait (HP:0002136)1.94817863
165Hypomagnesemia (HP:0002917)1.94804317
166Cerebral edema (HP:0002181)1.94175567
167Fair hair (HP:0002286)1.93072409
168Hypoplasia of the thymus (HP:0000778)1.92992606
169Hypergammaglobulinemia (HP:0010702)1.92907422
170Abnormal auditory evoked potentials (HP:0006958)1.90830327
171Abnormal hair whorl (HP:0010721)1.90346377
172Akinesia (HP:0002304)1.89531760
173Congenital primary aphakia (HP:0007707)1.89044605
174Xerostomia (HP:0000217)1.87829986
175Hepatocellular necrosis (HP:0001404)1.87810766
176Nasolacrimal duct obstruction (HP:0000579)1.87510182
177Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86461514
178Absent septum pellucidum (HP:0001331)1.84943850
179Abnormality of the septum pellucidum (HP:0007375)1.83458050
180Abnormal respiratory motile cilium physiology (HP:0012261)1.81894779
181Supranuclear gaze palsy (HP:0000605)1.81790959
182Short tibia (HP:0005736)1.80424025
183Epileptic encephalopathy (HP:0200134)1.78072263
184Lipid accumulation in hepatocytes (HP:0006561)1.77551612
185Adrenal hypoplasia (HP:0000835)1.76597326
186Progressive cerebellar ataxia (HP:0002073)1.76094424
187Generalized tonic-clonic seizures (HP:0002069)1.76089751
188Anomalous pulmonary venous return (HP:0010772)1.74748065
189Respiratory failure (HP:0002878)1.74475387
190Overfolded helix (HP:0000396)1.73218290
191Cerebral hemorrhage (HP:0001342)1.72997484
192Blue irides (HP:0000635)1.72570806
193Aplasia of the musculature (HP:0100854)1.71000314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.26566106
2CASK4.05791671
3TXK3.30942692
4PNCK3.06046556
5MST42.96745198
6MAP4K12.91039296
7TAOK32.78913598
8TNIK2.62591570
9OXSR12.52837801
10GRK62.37582991
11JAK12.24831624
12ZAP702.24569888
13CSK2.21086514
14PKN12.10525025
15NLK2.07248591
16ITK2.04926082
17BCR2.01661893
18BTK2.01493959
19PBK1.88522105
20MARK11.88285469
21TYK21.87767730
22TEC1.87705861
23WNK41.85361795
24EPHB11.83936698
25IKBKE1.82023267
26STK161.79963740
27FGFR41.79437111
28NME11.77424444
29ADRBK21.73285553
30CSNK1G31.70800521
31MAPKAPK51.67205538
32CAMKK21.64105072
33BMPR1B1.64058178
34UHMK11.63413216
35TNK21.60618571
36MAP2K71.53938625
37FGFR31.50361342
38FGR1.45674818
39FES1.45346909
40MAPK131.41663935
41MAP3K141.40647100
42GRK51.39905799
43LIMK11.39744100
44JAK31.38847559
45CAMK2B1.36389634
46SIK31.31872398
47PIK3CA1.31435575
48NEK61.31365004
49LCK1.29743426
50NTRK31.28127519
51STK241.27457780
52ARAF1.26389367
53EPHA31.26143461
54SYK1.26058908
55HCK1.25672090
56CAMK2A1.23994482
57EPHA21.23011063
58CSNK1G11.22253087
59MAP3K31.21877486
60BLK1.21407702
61EPHA41.21084931
62CSNK1G21.18570413
63ROCK21.17507254
64STK101.17300815
65IRAK31.16798859
66MAPKAPK31.13786708
67TRPM71.11476851
68CDK121.10900421
69CAMK2D1.09806446
70SCYL21.08974381
71TRIB31.08136359
72PRPF4B1.06592881
73PDGFRB1.04223849
74AKT31.03814062
75NTRK11.03299401
76CAMK2G1.03285399
77IRAK21.02795559
78LRRK21.01148841
79LMTK21.00887485
80BMPR21.00811421
81CAMKK11.00636488
82MAPK151.00606357
83JAK20.99175301
84PIK3CG0.97834859
85MAP3K40.95259225
86LYN0.94211192
87MARK30.93916715
88PASK0.93606832
89NTRK20.93313572
90FGFR20.93160316
91CSNK1A1L0.93119551
92MYLK0.89631641
93TBK10.89434830
94MELK0.86365402
95CDK190.85223623
96IKBKB0.84749664
97ADRBK10.83918201
98SRPK10.83747382
99STK380.83020287
100BUB10.82473843
101DYRK20.81973456
102TLK10.81114298
103MAP3K100.80519314
104CSF1R0.79404869
105PDK10.78691356
106GRK70.78473841
107ABL20.75393981
108PLK20.75170391
109HIPK20.75054449
110PIM10.74780181
111SGK20.74449261
112WNK10.74329801
113MAP3K10.73196342
114PRKCE0.71973130
115GSK3A0.69268714
116DYRK1A0.68370303
117TESK20.67619856
118YES10.67423606
119RET0.67366125
120TAOK10.65496036
121SGK30.65320917
122PRKCQ0.65297556
123MAP3K130.64675091
124MST1R0.64664794
125CDK50.64603048
126MAP3K20.63587727
127ERN10.62905900
128CAMK1G0.62613353
129PHKG20.62276362
130PHKG10.62276362
131PTK60.62239258
132SIK10.61925994
133PTK2B0.61423164
134MAP3K90.60722276
135ERBB40.60624298
136EEF2K0.58708772
137MARK20.58172336
138IRAK40.57738496
139PKN20.55620771
140EIF2AK20.55405971
141PAK30.55182222
142CDK60.55143814
143CDK80.54883817
144MUSK0.54845908
145MAP2K30.54747006
146RPS6KA50.53803727
147RIPK40.53321516
148PRKACA0.53178048
149CLK10.53091882
150BRAF0.52892026
151MAP2K20.52658143
152BMX0.52023553
153CDC42BPA0.50600610
154ERBB20.50462464
155TGFBR20.50410826
156MAP3K70.50239888
157INSRR0.49434958
158VRK10.49431593
159RIPK10.49188269
160MAPK110.48848873
161FYN0.48557751
162IRAK10.47924222
163CDK140.47383267
164CHUK0.47159974
165BRSK20.46284340
166CDK150.46208900
167CDK30.44953135
168CDK180.44405873
169GRK10.44318788
170ACVR1B0.44174666
171MKNK20.43499034
172TYRO30.43381901
173FER0.43139214
174CDK11A0.42662662
175MAP3K120.42147214
176MINK10.41895861
177CSNK1A10.39817222
178CAMK10.38639571
179PRKG10.36592531
180CSNK1E0.35556185
181SGK2230.35376130

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.55282464
2Parkinsons disease_Homo sapiens_hsa050123.64398605
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.43214554
4Primary immunodeficiency_Homo sapiens_hsa053403.29031548
5Alzheimers disease_Homo sapiens_hsa050103.02047703
6T cell receptor signaling pathway_Homo sapiens_hsa046603.01158998
7Steroid biosynthesis_Homo sapiens_hsa001002.73940656
8Protein export_Homo sapiens_hsa030602.54641221
9Nicotine addiction_Homo sapiens_hsa050332.51582238
10Ribosome_Homo sapiens_hsa030102.45907955
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.43893108
12Huntingtons disease_Homo sapiens_hsa050162.42038219
13Fatty acid elongation_Homo sapiens_hsa000622.26903182
14Ether lipid metabolism_Homo sapiens_hsa005652.24081464
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22227383
16Caffeine metabolism_Homo sapiens_hsa002322.20420237
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08548369
18Hematopoietic cell lineage_Homo sapiens_hsa046402.02899524
19Graft-versus-host disease_Homo sapiens_hsa053322.02282572
20Serotonergic synapse_Homo sapiens_hsa047262.02204535
21Measles_Homo sapiens_hsa051621.98986008
22B cell receptor signaling pathway_Homo sapiens_hsa046621.97072033
23Collecting duct acid secretion_Homo sapiens_hsa049661.94605458
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87963254
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85814050
26Allograft rejection_Homo sapiens_hsa053301.72927979
27Cardiac muscle contraction_Homo sapiens_hsa042601.72000311
28Platelet activation_Homo sapiens_hsa046111.71144554
29Osteoclast differentiation_Homo sapiens_hsa043801.70709383
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.67768829
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65565889
32Glutamatergic synapse_Homo sapiens_hsa047241.64986899
33Antigen processing and presentation_Homo sapiens_hsa046121.63097966
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62595316
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62393572
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.59151748
37Acute myeloid leukemia_Homo sapiens_hsa052211.56401365
38GABAergic synapse_Homo sapiens_hsa047271.54715790
39Sulfur metabolism_Homo sapiens_hsa009201.53239288
40Long-term depression_Homo sapiens_hsa047301.48425048
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.43995654
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43757060
43Linoleic acid metabolism_Homo sapiens_hsa005911.43254326
44Chemokine signaling pathway_Homo sapiens_hsa040621.43117539
45Taste transduction_Homo sapiens_hsa047421.40344612
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39768198
47Non-small cell lung cancer_Homo sapiens_hsa052231.39128879
48Axon guidance_Homo sapiens_hsa043601.38704611
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37458758
50Leishmaniasis_Homo sapiens_hsa051401.34140454
51Cocaine addiction_Homo sapiens_hsa050301.33777498
52Vibrio cholerae infection_Homo sapiens_hsa051101.30492460
53Morphine addiction_Homo sapiens_hsa050321.30278654
54Amphetamine addiction_Homo sapiens_hsa050311.29465573
55Hepatitis C_Homo sapiens_hsa051601.27807294
56TNF signaling pathway_Homo sapiens_hsa046681.24637733
57Pancreatic cancer_Homo sapiens_hsa052121.22813562
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22419884
59Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22259034
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19653839
61Phototransduction_Homo sapiens_hsa047441.18529223
62NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17050325
63Influenza A_Homo sapiens_hsa051641.15811263
64Synaptic vesicle cycle_Homo sapiens_hsa047211.15453874
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15450497
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15226968
67Type I diabetes mellitus_Homo sapiens_hsa049401.14453098
68Endometrial cancer_Homo sapiens_hsa052131.13975756
69Staphylococcus aureus infection_Homo sapiens_hsa051501.10429567
70Prolactin signaling pathway_Homo sapiens_hsa049171.10419628
71Sphingolipid metabolism_Homo sapiens_hsa006001.10368514
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07901285
73Renin secretion_Homo sapiens_hsa049241.07614406
74Thyroid cancer_Homo sapiens_hsa052161.05270654
75Herpes simplex infection_Homo sapiens_hsa051681.04736130
76Salivary secretion_Homo sapiens_hsa049701.04030020
77Toxoplasmosis_Homo sapiens_hsa051451.03769986
78Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01874002
79Viral myocarditis_Homo sapiens_hsa054161.01570886
80FoxO signaling pathway_Homo sapiens_hsa040681.00950957
81Rheumatoid arthritis_Homo sapiens_hsa053230.99954132
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99766257
83VEGF signaling pathway_Homo sapiens_hsa043700.99562258
84Cholinergic synapse_Homo sapiens_hsa047250.98179454
85Choline metabolism in cancer_Homo sapiens_hsa052310.98160985
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97374807
87Arachidonic acid metabolism_Homo sapiens_hsa005900.97046169
88Pancreatic secretion_Homo sapiens_hsa049720.95298149
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.93798055
90Malaria_Homo sapiens_hsa051440.92837559
91Hepatitis B_Homo sapiens_hsa051610.92758346
92Gastric acid secretion_Homo sapiens_hsa049710.92480559
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91717010
94Inositol phosphate metabolism_Homo sapiens_hsa005620.91574303
95Renal cell carcinoma_Homo sapiens_hsa052110.91375129
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91223254
97Prostate cancer_Homo sapiens_hsa052150.90634424
98Dopaminergic synapse_Homo sapiens_hsa047280.90033043
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89082565
100Circadian entrainment_Homo sapiens_hsa047130.89068590
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88470316
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.88421059
103Chronic myeloid leukemia_Homo sapiens_hsa052200.85797673
104Histidine metabolism_Homo sapiens_hsa003400.85772372
105Tuberculosis_Homo sapiens_hsa051520.85574339
106Long-term potentiation_Homo sapiens_hsa047200.82750037
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82681703
108Tyrosine metabolism_Homo sapiens_hsa003500.82600761
109ABC transporters_Homo sapiens_hsa020100.81827349
110Circadian rhythm_Homo sapiens_hsa047100.80496864
111Proteasome_Homo sapiens_hsa030500.80055119
112Apoptosis_Homo sapiens_hsa042100.79758349
113Insulin resistance_Homo sapiens_hsa049310.79453206
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79266151
115Butanoate metabolism_Homo sapiens_hsa006500.79019673
116mTOR signaling pathway_Homo sapiens_hsa041500.78731095
117Calcium signaling pathway_Homo sapiens_hsa040200.78080901
118Endocytosis_Homo sapiens_hsa041440.76000866
119Melanogenesis_Homo sapiens_hsa049160.75450230
120Glycerolipid metabolism_Homo sapiens_hsa005610.74534284
121RNA polymerase_Homo sapiens_hsa030200.74339420
122Hedgehog signaling pathway_Homo sapiens_hsa043400.72644199
123Fat digestion and absorption_Homo sapiens_hsa049750.72153242
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69932346
125Colorectal cancer_Homo sapiens_hsa052100.69796233
126African trypanosomiasis_Homo sapiens_hsa051430.69478818
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67626840
128Legionellosis_Homo sapiens_hsa051340.67514428
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66898459
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.66299956
131Gap junction_Homo sapiens_hsa045400.64986149
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64122893
133Viral carcinogenesis_Homo sapiens_hsa052030.63601273
134Adherens junction_Homo sapiens_hsa045200.61148030
135Fatty acid biosynthesis_Homo sapiens_hsa000610.59450140
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59004015
137Ovarian steroidogenesis_Homo sapiens_hsa049130.57393337
138Shigellosis_Homo sapiens_hsa051310.56835570
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56146203
140Oxytocin signaling pathway_Homo sapiens_hsa049210.55124157
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.55003130
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54458621
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54458215
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53705039
145Phagosome_Homo sapiens_hsa041450.53360070
146HTLV-I infection_Homo sapiens_hsa051660.52946857
147Insulin secretion_Homo sapiens_hsa049110.52908848
148Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52299404
149Phenylalanine metabolism_Homo sapiens_hsa003600.52177532
150Starch and sucrose metabolism_Homo sapiens_hsa005000.50558937
151Metabolic pathways_Homo sapiens_hsa011000.50457541
152ErbB signaling pathway_Homo sapiens_hsa040120.49844709
153Arginine and proline metabolism_Homo sapiens_hsa003300.48764674
154Neurotrophin signaling pathway_Homo sapiens_hsa047220.48569120
155Renin-angiotensin system_Homo sapiens_hsa046140.47331809
156Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46611262
157GnRH signaling pathway_Homo sapiens_hsa049120.43749002
158Notch signaling pathway_Homo sapiens_hsa043300.43655697
159Adipocytokine signaling pathway_Homo sapiens_hsa049200.43647622
160Basal cell carcinoma_Homo sapiens_hsa052170.42715017
161Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42216752
162Glutathione metabolism_Homo sapiens_hsa004800.41019591
163Autoimmune thyroid disease_Homo sapiens_hsa053200.39992515
164Ras signaling pathway_Homo sapiens_hsa040140.39643972
165Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39387598
166Alcoholism_Homo sapiens_hsa050340.38929601
167Mineral absorption_Homo sapiens_hsa049780.37000018
168Steroid hormone biosynthesis_Homo sapiens_hsa001400.35224667
169Glycosaminoglycan degradation_Homo sapiens_hsa005310.35187723
170ECM-receptor interaction_Homo sapiens_hsa045120.34580695
171Protein digestion and absorption_Homo sapiens_hsa049740.30957718
172Wnt signaling pathway_Homo sapiens_hsa043100.30793003
173Tight junction_Homo sapiens_hsa045300.30293284
174Phospholipase D signaling pathway_Homo sapiens_hsa040720.30021470
175Prion diseases_Homo sapiens_hsa050200.27066555
176Aldosterone synthesis and secretion_Homo sapiens_hsa049250.26921402
177Dorso-ventral axis formation_Homo sapiens_hsa043200.24119599
178Non-homologous end-joining_Homo sapiens_hsa034500.23353865
179Olfactory transduction_Homo sapiens_hsa047400.22604626
180Retinol metabolism_Homo sapiens_hsa008300.22384275
181cAMP signaling pathway_Homo sapiens_hsa040240.22236343
182Estrogen signaling pathway_Homo sapiens_hsa049150.20770845
183Melanoma_Homo sapiens_hsa052180.20576768
184Chemical carcinogenesis_Homo sapiens_hsa052040.18441308

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