ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	6.18463167
2	nucleobase catabolic process (GO:0046113)	4.72671696
3	positive regulation of mitochondrial fission (GO:0090141)	4.10088594
4	sequestering of actin monomers (GO:0042989)	3.50629993
5	presynaptic membrane assembly (GO:0097105)	3.46641584
6	neuron cell-cell adhesion (GO:0007158)	3.31342868
7	establishment of mitochondrion localization (GO:0051654)	3.24572971
8	Golgi transport vesicle coating (GO:0048200)	3.14506195
9	COPI coating of Golgi vesicle (GO:0048205)	3.14506195
10	axonal fasciculation (GO:0007413)	3.12012836
11	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.11161935
12	renal system development (GO:0072001)	3.07625904
13	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.99189456
14	limb bud formation (GO:0060174)	2.95650442
15	vocalization behavior (GO:0071625)	2.90112296
16	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	2.87449763
17	cholesterol biosynthetic process (GO:0006695)	2.86396115
18	presynaptic membrane organization (GO:0097090)	2.85304969
19	layer formation in cerebral cortex (GO:0021819)	2.85084972
20	postsynaptic membrane organization (GO:0001941)	2.84988685
21	hippocampus development (GO:0021766)	2.81196865
22	negative regulation of axon guidance (GO:1902668)	2.78276778
23	peptidyl-arginine omega-N-methylation (GO:0035247)	2.76190434
24	neurotransmitter-gated ion channel clustering (GO:0072578)	2.73599813
25	regulation of cAMP-dependent protein kinase activity (GO:2000479)	2.73580867
26	regulation of mitochondrial fission (GO:0090140)	2.71888857
27	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.68151071
28	peptidyl-arginine methylation (GO:0018216)	2.67210717
29	peptidyl-arginine N-methylation (GO:0035246)	2.67210717
30	synapse assembly (GO:0007416)	2.65867001
31	neuron recognition (GO:0008038)	2.63726440
32	axon extension involved in axon guidance (GO:0048846)	2.61064485
33	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.61064485
34	axon extension (GO:0048675)	2.59506167
35	protein localization to synapse (GO:0035418)	2.57252196
36	retinal ganglion cell axon guidance (GO:0031290)	2.54263291
37	cell migration in hindbrain (GO:0021535)	2.52995391
38	L-serine transport (GO:0015825)	2.51812019
39	positive regulation of synapse assembly (GO:0051965)	2.51259115
40	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.49402046
41	gamma-aminobutyric acid transport (GO:0015812)	2.46625527
42	olfactory bulb development (GO:0021772)	2.46070786
43	sterol biosynthetic process (GO:0016126)	2.42332694
44	growth hormone secretion (GO:0030252)	2.42208736
45	protein localization to cilium (GO:0061512)	2.38143947
46	regulation of axon guidance (GO:1902667)	2.36877714
47	mitochondrion transport along microtubule (GO:0047497)	2.36248888
48	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.36248888
49	multicellular organismal aging (GO:0010259)	2.33818045
50	ganglion development (GO:0061548)	2.33165696
51	negative chemotaxis (GO:0050919)	2.30853583
52	central nervous system projection neuron axonogenesis (GO:0021952)	2.30187214
53	paraxial mesoderm development (GO:0048339)	2.29757403
54	regulation of synapse assembly (GO:0051963)	2.29532197
55	DNA integration (GO:0015074)	2.28729728
56	neuronal ion channel clustering (GO:0045161)	2.28670674
57	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.26489478
58	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.25947697
59	glucocorticoid biosynthetic process (GO:0006704)	2.24069417
60	ephrin receptor signaling pathway (GO:0048013)	2.23854553
61	muscle cell cellular homeostasis (GO:0046716)	2.23761328
62	organelle transport along microtubule (GO:0072384)	2.21011051
63	lens morphogenesis in camera-type eye (GO:0002089)	2.20917675
64	cranial nerve morphogenesis (GO:0021602)	2.19802948
65	intraciliary transport (GO:0042073)	2.18214787
66	positive regulation of dendrite morphogenesis (GO:0050775)	2.16743610
67	regulation of development, heterochronic (GO:0040034)	2.16697972
68	negative regulation of microtubule polymerization (GO:0031115)	2.16214178
69	response to follicle-stimulating hormone (GO:0032354)	2.15165759
70	protein insertion into membrane (GO:0051205)	2.15138774
71	neuron fate commitment (GO:0048663)	2.14493492
72	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.14480956
73	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.13158633
74	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.13019971
75	central nervous system neuron axonogenesis (GO:0021955)	2.12561630
76	neuron projection extension (GO:1990138)	2.10968928
77	somite development (GO:0061053)	2.10501552
78	cytoskeleton-dependent intracellular transport (GO:0030705)	2.10143635
79	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.08660943
80	estrogen biosynthetic process (GO:0006703)	2.08104787
81	establishment of nucleus localization (GO:0040023)	2.07787542
82	endoplasmic reticulum organization (GO:0007029)	2.07332191
83	synapse organization (GO:0050808)	2.06105074
84	dendritic spine organization (GO:0097061)	2.04747205
85	cerebral cortex radially oriented cell migration (GO:0021799)	2.03745443
86	forebrain neuron differentiation (GO:0021879)	2.03478511
87	cerebral cortex cell migration (GO:0021795)	2.03046757
88	neurotransmitter catabolic process (GO:0042135)	2.01714563
89	regulation of timing of cell differentiation (GO:0048505)	2.01150598
90	gastrulation with mouth forming second (GO:0001702)	2.01124904
91	ectodermal placode formation (GO:0060788)	2.00279535
92	histone arginine methylation (GO:0034969)	1.99895400
93	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	1.99167511
94	nucleoside bisphosphate biosynthetic process (GO:0033866)	1.99167511
95	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	1.99167511
96	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)	1.99063775
97	positive regulation of receptor biosynthetic process (GO:0010870)	1.97451713
98	synaptic vesicle endocytosis (GO:0048488)	1.95938707
99	de novo posttranslational protein folding (GO:0051084)	1.95544112
100	short-term memory (GO:0007614)	1.94231904

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.30930763
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.24340857
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.14273412
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.05408745
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.91441043
6	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.90555384
7	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.89531542
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.66752857
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.47793436
10	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.28537828
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.12323327
12	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.07553945
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.99740455
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.97125576
15	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.92761358
16	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.90006941
17	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.88748171
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.86373674
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.84263723
20	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.77195158
21	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.76210031
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.71874465
23	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.65551948
24	AR_21572438_ChIP-Seq_LNCaP_Human	1.63594730
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.62944831
26	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.62038549
27	RNF2_27304074_Chip-Seq_NSC_Mouse	1.60879613
28	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.59985615
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56002601
30	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.52203710
31	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.46704989
32	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.46704989
33	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.45592855
34	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.41360236
35	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.40614338
36	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.40210823
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34086257
38	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33763602
39	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.31315517
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.30822675
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29804337
42	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.27568470
43	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.22188109
44	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.21228245
45	FUS_26573619_Chip-Seq_HEK293_Human	1.20331338
46	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.18556924
47	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17957218
48	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.16676955
49	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16373228
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.15385800
51	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.14474716
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.14455478
53	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.14370027
54	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.12445799
55	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.11988716
56	TP53_18474530_ChIP-ChIP_U2OS_Human	1.11330557
57	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11179762
58	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.11063842
59	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.11055556
60	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.10799272
61	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.10512101
62	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10456998
63	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.10244443
64	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.09416784
65	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.08585406
66	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.06440664
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06089539
68	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.05029640
69	SOX9_26525672_Chip-Seq_HEART_Mouse	1.04717418
70	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04427058
71	P300_19829295_ChIP-Seq_ESCs_Human	1.02065548
72	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.01101190
73	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.01013134
74	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.00849715
75	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.00754862
76	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.00489648
77	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.00475032
78	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.99784658
79	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.99230700
80	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.97910862
81	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.97555621
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97432411
83	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.95099288
84	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.94411982
85	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.93949165
86	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.93678405
87	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.93678405
88	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.93677576
89	CLOCK_20551151_ChIP-Seq_293T_Human	0.93603580
90	AR_19668381_ChIP-Seq_PC3_Human	0.93387052
91	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.93133516
92	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.91925385
93	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.91798927
94	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.91001559
95	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.89609395
96	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.89296612
97	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87655801
98	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.87340323
99	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.86364003
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.85873690

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	3.04818272
2	MP0006276_abnormal_autonomic_nervous	2.63551653
3	MP0001529_abnormal_vocalization	2.62278545
4	MP0000751_myopathy	2.52674739
5	MP0005394_taste/olfaction_phenotype	2.49534160
6	MP0005499_abnormal_olfactory_system	2.49534160
7	MP0002822_catalepsy	2.40201729
8	MP0003122_maternal_imprinting	2.36871210
9	MP0010030_abnormal_orbit_morphology	2.31229477
10	MP0008789_abnormal_olfactory_epithelium	2.22409595
11	MP0004272_abnormal_basement_membrane	2.09706465
12	MP0008438_abnormal_cutaneous_collagen	2.03878097
13	MP0004270_analgesia	1.97198671
14	MP0003880_abnormal_central_pattern	1.95938326
15	MP0000778_abnormal_nervous_system	1.89277839
16	MP0001984_abnormal_olfaction	1.79036386
17	MP0002102_abnormal_ear_morphology	1.73934612
18	MP0001299_abnormal_eye_distance/	1.71698880
19	MP0005171_absent_coat_pigmentation	1.70035593
20	MP0000049_abnormal_middle_ear	1.69623440
21	MP0005248_abnormal_Harderian_gland	1.65392859
22	MP0002249_abnormal_larynx_morphology	1.61139806
23	MP0002233_abnormal_nose_morphology	1.56199797
24	MP0009384_cardiac_valve_regurgitation	1.51377556
25	MP0003385_abnormal_body_wall	1.50745233
26	MP0000013_abnormal_adipose_tissue	1.49921424
27	MP0002282_abnormal_trachea_morphology	1.42734396
28	MP0005187_abnormal_penis_morphology	1.40993938
29	MP0002234_abnormal_pharynx_morphology	1.40499721
30	MP0004859_abnormal_synaptic_plasticity	1.39656198
31	MP0002184_abnormal_innervation	1.34357032
32	MP0002938_white_spotting	1.31495516
33	MP0005423_abnormal_somatic_nervous	1.30024255
34	MP0003937_abnormal_limbs/digits/tail_de	1.27328452
35	MP0005257_abnormal_intraocular_pressure	1.25993169
36	MP0002751_abnormal_autonomic_nervous	1.24894060
37	MP0000750_abnormal_muscle_regeneration	1.23750187
38	MP0002653_abnormal_ependyma_morphology	1.23421008
39	MP0003755_abnormal_palate_morphology	1.20764044
40	MP0004145_abnormal_muscle_electrophysio	1.17434740
41	MP0004133_heterotaxia	1.14118206
42	MP0003121_genomic_imprinting	1.13423573
43	MP0002909_abnormal_adrenal_gland	1.12966276
44	MP0000534_abnormal_ureter_morphology	1.12924105
45	MP0002638_abnormal_pupillary_reflex	1.11119685
46	MP0005623_abnormal_meninges_morphology	1.09782856
47	MP0000639_abnormal_adrenal_gland	1.09271118
48	MP0002697_abnormal_eye_size	1.08556014
49	MP0000579_abnormal_nail_morphology	1.08147260
50	MP0003221_abnormal_cardiomyocyte_apopto	1.08053832
51	MP0001270_distended_abdomen	1.06997483
52	MP0000955_abnormal_spinal_cord	1.06846213
53	MP0003942_abnormal_urinary_system	1.06576494
54	MP0000631_abnormal_neuroendocrine_gland	1.05780114
55	MP0008995_early_reproductive_senescence	1.04474059
56	MP0009780_abnormal_chondrocyte_physiolo	1.04222129
57	MP0004811_abnormal_neuron_physiology	1.03789473
58	MP0003136_yellow_coat_color	1.00700230
59	MP0003635_abnormal_synaptic_transmissio	0.99279621
60	MP0003861_abnormal_nervous_system	0.97582848
61	MP0009046_muscle_twitch	0.97401555
62	MP0000749_muscle_degeneration	0.96564062
63	MP0001188_hyperpigmentation	0.95421227
64	MP0003935_abnormal_craniofacial_develop	0.90871071
65	MP0002882_abnormal_neuron_morphology	0.90745338
66	MP0000537_abnormal_urethra_morphology	0.89724020
67	MP0002735_abnormal_chemical_nociception	0.89462857
68	MP0002063_abnormal_learning/memory/cond	0.88601155
69	MP0005253_abnormal_eye_physiology	0.86413046
70	MP0003938_abnormal_ear_development	0.86366392
71	MP0003119_abnormal_digestive_system	0.86069237
72	MP0006292_abnormal_olfactory_placode	0.84755906
73	MP0002572_abnormal_emotion/affect_behav	0.84404564
74	MP0002557_abnormal_social/conspecific_i	0.84026751
75	MP0002116_abnormal_craniofacial_bone	0.83858888
76	MP0001502_abnormal_circadian_rhythm	0.83807717
77	MP0002752_abnormal_somatic_nervous	0.82332363
78	MP0003567_abnormal_fetal_cardiomyocyte	0.82157277
79	MP0001661_extended_life_span	0.80733504
80	MP0000462_abnormal_digestive_system	0.80722322
81	MP0002152_abnormal_brain_morphology	0.80618671
82	MP0005391_vision/eye_phenotype	0.78945418
83	MP0002734_abnormal_mechanical_nocicepti	0.78777425
84	MP0000026_abnormal_inner_ear	0.78071705
85	MP0002108_abnormal_muscle_morphology	0.77504282
86	MP0003115_abnormal_respiratory_system	0.76580931
87	MP0001286_abnormal_eye_development	0.75528092
88	MP0006072_abnormal_retinal_apoptosis	0.74574150
89	MP0009250_abnormal_appendicular_skeleto	0.73943179
90	MP0000647_abnormal_sebaceous_gland	0.73546875
91	MP0002269_muscular_atrophy	0.72783699
92	MP0005645_abnormal_hypothalamus_physiol	0.72131961
93	MP0005508_abnormal_skeleton_morphology	0.72046163
94	MP0002081_perinatal_lethality	0.71960296
95	MP0005646_abnormal_pituitary_gland	0.71908453
96	MP0005503_abnormal_tendon_morphology	0.71758419
97	MP0001346_abnormal_lacrimal_gland	0.71289605
98	MP0002106_abnormal_muscle_physiology	0.70426852
99	MP0003137_abnormal_impulse_conducting	0.69710355
100	MP0002177_abnormal_outer_ear	0.69577499

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Shoulder girdle muscle weakness (HP:0003547)	3.03595155
2	Cortical dysplasia (HP:0002539)	3.02294071
3	Abnormality of the hip-girdle musculature (HP:0001445)	2.80823947
4	Abnormality of the musculature of the pelvis (HP:0001469)	2.80823947
5	Back pain (HP:0003418)	2.80124720
6	Abnormality of the labia minora (HP:0012880)	2.78225133
7	Limb-girdle muscle atrophy (HP:0003797)	2.76319820
8	Hypoplasia of the brainstem (HP:0002365)	2.59701262
9	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.59701262
10	Wrist flexion contracture (HP:0001239)	2.51210691
11	Neoplasm of the heart (HP:0100544)	2.44231710
12	Pelvic girdle muscle weakness (HP:0003749)	2.35805069
13	Premature rupture of membranes (HP:0001788)	2.26032796
14	Limb-girdle muscle weakness (HP:0003325)	2.23179300
15	Abnormality of dentin (HP:0010299)	2.22206774
16	Drooling (HP:0002307)	2.22022485
17	Pachygyria (HP:0001302)	2.20940786
18	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.19015993
19	Short 4th metacarpal (HP:0010044)	2.19015993
20	Abnormality of the lower motor neuron (HP:0002366)	2.15247346
21	Retinal dysplasia (HP:0007973)	2.13281843
22	Lissencephaly (HP:0001339)	2.11860284
23	Microglossia (HP:0000171)	2.03244949
24	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.02151938
25	Hypoventilation (HP:0002791)	1.99318228
26	Gait imbalance (HP:0002141)	1.98061644
27	Short tibia (HP:0005736)	1.97215267
28	Hemivertebrae (HP:0002937)	1.93754931
29	Occipital encephalocele (HP:0002085)	1.93118324
30	Difficulty climbing stairs (HP:0003551)	1.90350203
31	Breech presentation (HP:0001623)	1.89214000
32	Genital tract atresia (HP:0001827)	1.89071576
33	Short nail (HP:0001799)	1.88461422
34	Protrusio acetabuli (HP:0003179)	1.87718488
35	Excessive salivation (HP:0003781)	1.86545577
36	Failure to thrive in infancy (HP:0001531)	1.84931249
37	Congenital primary aphakia (HP:0007707)	1.84649705
38	Open mouth (HP:0000194)	1.82953773
39	Split foot (HP:0001839)	1.82003380
40	Nephrogenic diabetes insipidus (HP:0009806)	1.81795620
41	Abnormality of the calf musculature (HP:0001430)	1.79741742
42	Hemiparesis (HP:0001269)	1.78643740
43	Rimmed vacuoles (HP:0003805)	1.76213767
44	Pterygium (HP:0001059)	1.73446559
45	Hyperacusis (HP:0010780)	1.73038088
46	Anterior segment dysgenesis (HP:0007700)	1.73029653
47	Hypoplastic pelvis (HP:0008839)	1.73002252
48	Delayed gross motor development (HP:0002194)	1.69184587
49	Renal dysplasia (HP:0000110)	1.69116257
50	Trigonocephaly (HP:0000243)	1.68798681
51	Gastrointestinal atresia (HP:0002589)	1.68429490
52	Medial flaring of the eyebrow (HP:0010747)	1.64327488
53	Vaginal atresia (HP:0000148)	1.64099429
54	Labial hypoplasia (HP:0000066)	1.63738890
55	Micropenis (HP:0000054)	1.62960020
56	Medulloblastoma (HP:0002885)	1.62847086
57	Hand muscle atrophy (HP:0009130)	1.62560708
58	Abnormality of the 4th metacarpal (HP:0010012)	1.59485171
59	Hyperglycinemia (HP:0002154)	1.58817072
60	Decreased testicular size (HP:0008734)	1.58065711
61	Polyphagia (HP:0002591)	1.57685272
62	Abnormal gallbladder physiology (HP:0012438)	1.57307949
63	Cholecystitis (HP:0001082)	1.57307949
64	Cutaneous finger syndactyly (HP:0010554)	1.57118545
65	Cutaneous syndactyly (HP:0012725)	1.55446448
66	Thin ribs (HP:0000883)	1.54714250
67	Vitreoretinal degeneration (HP:0000655)	1.54708696
68	Large earlobe (HP:0009748)	1.54385209
69	Infantile muscular hypotonia (HP:0008947)	1.53552911
70	Specific learning disability (HP:0001328)	1.52847012
71	Spina bifida occulta (HP:0003298)	1.52395217
72	Polymicrogyria (HP:0002126)	1.52372872
73	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.51782797
74	Bladder diverticulum (HP:0000015)	1.51731649
75	Mitral stenosis (HP:0001718)	1.51701793
76	Bowel diverticulosis (HP:0005222)	1.51611083
77	Poor suck (HP:0002033)	1.51374981
78	Spinal rigidity (HP:0003306)	1.50825195
79	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.50807878
80	Renovascular hypertension (HP:0100817)	1.49280081
81	Amyotrophic lateral sclerosis (HP:0007354)	1.49078407
82	Severe muscular hypotonia (HP:0006829)	1.48404430
83	Tubulointerstitial nephritis (HP:0001970)	1.47264920
84	Abnormality of the labia (HP:0000058)	1.47255171
85	Cystic liver disease (HP:0006706)	1.46613954
86	Megalocornea (HP:0000485)	1.46212181
87	Neonatal respiratory distress (HP:0002643)	1.45423125
88	Sprengel anomaly (HP:0000912)	1.45412099
89	Abnormality of the aortic arch (HP:0012303)	1.45074099
90	Poor coordination (HP:0002370)	1.44501252
91	Morphological abnormality of the middle ear (HP:0008609)	1.43240692
92	Hypoplastic female external genitalia (HP:0012815)	1.43167577
93	Abnormality of the shoulder girdle musculature (HP:0001435)	1.43144469
94	Distal upper limb amyotrophy (HP:0007149)	1.42954743
95	Upper limb amyotrophy (HP:0009129)	1.42954743
96	Long toe (HP:0010511)	1.42781701
97	Progressive cerebellar ataxia (HP:0002073)	1.42703838
98	Severe Myopia (HP:0011003)	1.41546143
99	Spastic tetraplegia (HP:0002510)	1.40997020
100	Coronal craniosynostosis (HP:0004440)	1.40675504

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.07585753
2	BCR	3.43687250
3	EPHA3	3.21328848
4	MAP4K2	3.15533242
5	MAP2K7	3.04286244
6	MAP3K4	3.03173485
7	CASK	2.75166703
8	WNK3	2.38354481
9	CSNK1G3	2.14140480
10	CSNK1A1L	2.10809050
11	ERBB3	1.99056474
12	AKT3	1.98320280
13	CSNK1G2	1.83679875
14	STK38L	1.82952450
15	CSNK1G1	1.81564108
16	DYRK2	1.77872489
17	TRIM28	1.74730728
18	DYRK1B	1.72856410
19	BCKDK	1.70692903
20	EPHB2	1.61528581
21	DYRK3	1.56935783
22	PAK6	1.37272332
23	MAPK13	1.36776432
24	MAP3K6	1.34942507
25	SRPK1	1.31479059
26	PAK3	1.26520908
27	LMTK2	1.24549157
28	LIMK1	1.23621834
29	KSR1	1.21769545
30	NTRK2	1.21529136
31	MET	1.19441385
32	EPHA4	1.14909342
33	NTRK1	1.13880127
34	PDGFRA	1.10664233
35	PIM2	1.06199819
36	MAP2K4	1.04027908
37	LATS1	1.03474222
38	PINK1	1.02854374
39	TESK1	1.02657996
40	TSSK6	1.02596699
41	SGK494	1.02263441
42	SGK223	1.02263441
43	MINK1	1.00724715
44	MUSK	0.95058621
45	KSR2	0.94070396
46	MAPK15	0.90534465
47	MAPKAPK5	0.88248584
48	CAMK4	0.87096574
49	DDR2	0.85040063
50	FER	0.84361440
51	CAMK2B	0.84137695
52	RET	0.81921784
53	PKN2	0.79337692
54	AKT2	0.76206413
55	SGK2	0.73298625
56	CDK14	0.73216964
57	RAF1	0.72700000
58	PRKAA1	0.71344957
59	OBSCN	0.67255058
60	ICK	0.66661596
61	CDK18	0.66480280
62	EPHA2	0.65895280
63	RPS6KA4	0.64989746
64	PRKCE	0.64495995
65	TIE1	0.61561806
66	TESK2	0.60595467
67	CDK15	0.59939188
68	MAP3K5	0.58684880
69	PTK2	0.58358946
70	EPHB1	0.58039972
71	CDK5	0.58020259
72	UHMK1	0.57726997
73	STK38	0.56344416
74	CAMK2G	0.55888853
75	VRK1	0.55119693
76	FGFR2	0.54499061
77	RPS6KA5	0.54187331
78	TTN	0.53280348
79	PAK2	0.52554206
80	PKN1	0.52507480
81	PHKG2	0.52203891
82	PHKG1	0.52203891
83	CAMK2A	0.51762032
84	FLT3	0.51717244
85	CDK11A	0.50620983
86	CSNK1D	0.49013240
87	WNK4	0.47396371
88	PRKD3	0.45953184
89	SGK3	0.43853890
90	AURKA	0.40978444
91	PIK3CA	0.39961438
92	PRKCG	0.39646986
93	CCNB1	0.39334839
94	ERBB4	0.39231710
95	DYRK1A	0.39057532
96	DAPK2	0.38449741
97	CAMK2D	0.38348655
98	RPS6KA2	0.37164740
99	DAPK3	0.36093961
100	MAP3K7	0.34289470

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Steroid biosynthesis_Homo sapiens_hsa00100	3.11902783
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.59263837
3	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.26120202
4	Protein export_Homo sapiens_hsa03060	1.86383596
5	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.85514628
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.81344925
7	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.69302332
8	Nicotine addiction_Homo sapiens_hsa05033	1.63053605
9	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.59437578
10	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.54324780
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.48922864
12	Axon guidance_Homo sapiens_hsa04360	1.45249200
13	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.42828906
14	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.42191585
15	Vibrio cholerae infection_Homo sapiens_hsa05110	1.37317950
16	ECM-receptor interaction_Homo sapiens_hsa04512	1.34517539
17	Propanoate metabolism_Homo sapiens_hsa00640	1.33240384
18	Cocaine addiction_Homo sapiens_hsa05030	1.32838706
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.31720522
20	Butanoate metabolism_Homo sapiens_hsa00650	1.31121991
21	GABAergic synapse_Homo sapiens_hsa04727	1.28972392
22	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.26063208
23	Fatty acid elongation_Homo sapiens_hsa00062	1.25884434
24	Basal cell carcinoma_Homo sapiens_hsa05217	1.24166401
25	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.23855275
26	Gap junction_Homo sapiens_hsa04540	1.23762639
27	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.21547137
28	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.18109390
29	Hippo signaling pathway_Homo sapiens_hsa04390	1.16168004
30	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.15936705
31	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.12728986
32	Alcoholism_Homo sapiens_hsa05034	1.12518543
33	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.10081230
34	Carbon metabolism_Homo sapiens_hsa01200	1.07549328
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.02853402
36	Fatty acid metabolism_Homo sapiens_hsa01212	1.02703172
37	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.02652458
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.99107352
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.96895673
40	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.94886768
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.94795854
42	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.93074083
43	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.92632849
44	Pyruvate metabolism_Homo sapiens_hsa00620	0.89078135
45	Long-term depression_Homo sapiens_hsa04730	0.87624660
46	Fanconi anemia pathway_Homo sapiens_hsa03460	0.87142006
47	Circadian entrainment_Homo sapiens_hsa04713	0.85533112
48	Dopaminergic synapse_Homo sapiens_hsa04728	0.82777513
49	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.82180635
50	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.81439307
51	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.79847804
52	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.77946024
53	AMPK signaling pathway_Homo sapiens_hsa04152	0.77654983
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.74069922
55	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.73176166
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.72741177
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.71295413
58	Sulfur relay system_Homo sapiens_hsa04122	0.71143806
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.70040553
60	Circadian rhythm_Homo sapiens_hsa04710	0.68916660
61	ABC transporters_Homo sapiens_hsa02010	0.68672320
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.67682398
63	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.66708281
64	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.66428405
65	Melanogenesis_Homo sapiens_hsa04916	0.64428341
66	Focal adhesion_Homo sapiens_hsa04510	0.64266142
67	Arginine biosynthesis_Homo sapiens_hsa00220	0.64220385
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60757173
69	Amphetamine addiction_Homo sapiens_hsa05031	0.60525544
70	Taste transduction_Homo sapiens_hsa04742	0.59704930
71	Tight junction_Homo sapiens_hsa04530	0.59357106
72	Non-homologous end-joining_Homo sapiens_hsa03450	0.59247338
73	Peroxisome_Homo sapiens_hsa04146	0.58310086
74	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.58245646
75	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.55394954
76	Phototransduction_Homo sapiens_hsa04744	0.54752338
77	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.54680930
78	Morphine addiction_Homo sapiens_hsa05032	0.54553272
79	Pentose phosphate pathway_Homo sapiens_hsa00030	0.53821864
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.52787328
81	Insulin secretion_Homo sapiens_hsa04911	0.50498168
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.49886826
83	Lysine degradation_Homo sapiens_hsa00310	0.46236159
84	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.44298887
85	Oocyte meiosis_Homo sapiens_hsa04114	0.43531134
86	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.43364031
87	Cholinergic synapse_Homo sapiens_hsa04725	0.42936474
88	Adherens junction_Homo sapiens_hsa04520	0.42675768
89	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.42415374
90	Wnt signaling pathway_Homo sapiens_hsa04310	0.42042941
91	Protein digestion and absorption_Homo sapiens_hsa04974	0.41924949
92	Galactose metabolism_Homo sapiens_hsa00052	0.41010257
93	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40987944
94	mRNA surveillance pathway_Homo sapiens_hsa03015	0.40311249
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.39761804
96	Parkinsons disease_Homo sapiens_hsa05012	0.39740833
97	Colorectal cancer_Homo sapiens_hsa05210	0.39508335
98	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.38468666
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38164845
100	Basal transcription factors_Homo sapiens_hsa03022	0.37685703

TCAF1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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