TCAF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in prostate gland morphogenesis (GO:0060442)9.62690359
2prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060527.20117651
3artery development (GO:0060840)6.68453327
4regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)6.42511940
5prostate gland epithelium morphogenesis (GO:0060740)6.36145676
6L-fucose catabolic process (GO:0042355)5.77233898
7fucose catabolic process (GO:0019317)5.77233898
8L-fucose metabolic process (GO:0042354)5.77233898
9COPI coating of Golgi vesicle (GO:0048205)5.63708262
10Golgi transport vesicle coating (GO:0048200)5.63708262
11epithelial cell differentiation involved in prostate gland development (GO:0060742)5.31828140
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.30473280
13mannose metabolic process (GO:0006013)5.14153242
14response to testosterone (GO:0033574)5.00751972
15regulation of receptor binding (GO:1900120)4.97761298
16positive regulation of natural killer cell differentiation (GO:0032825)4.87906148
17hemidesmosome assembly (GO:0031581)4.80680756
18mitotic cell cycle arrest (GO:0071850)4.77284821
19indole-containing compound catabolic process (GO:0042436)4.74645802
20indolalkylamine catabolic process (GO:0046218)4.74645802
21tryptophan catabolic process (GO:0006569)4.74645802
22valine metabolic process (GO:0006573)4.71084441
23positive regulation of steroid hormone secretion (GO:2000833)4.67288955
24behavioral response to nicotine (GO:0035095)4.65523632
25UDP-N-acetylglucosamine metabolic process (GO:0006047)4.60188076
26ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.57646059
27indolalkylamine metabolic process (GO:0006586)4.57380065
28galactose catabolic process (GO:0019388)4.54716278
29pharyngeal system development (GO:0060037)4.51093713
30kynurenine metabolic process (GO:0070189)4.45106757
31fucose metabolic process (GO:0006004)4.38072510
32activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.29388415
33intestinal epithelial cell development (GO:0060576)4.28905780
34protein retention in ER lumen (GO:0006621)4.20488564
35activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.19294518
36lung secretory cell differentiation (GO:0061140)4.17888644
37epithelial cell maturation (GO:0002070)4.11762495
38N-glycan processing (GO:0006491)4.10566409
39tryptophan metabolic process (GO:0006568)4.08738496
40positive regulation of nuclease activity (GO:0032075)4.06947421
41apoptotic cell clearance (GO:0043277)4.01848132
42hormone catabolic process (GO:0042447)3.99329539
43desmosome organization (GO:0002934)3.96736884
44signal peptide processing (GO:0006465)3.87427165
45establishment of protein localization to Golgi (GO:0072600)3.77359096
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.74500336
47regulation of nuclease activity (GO:0032069)3.72641783
48cellular ketone body metabolic process (GO:0046950)3.72535162
49endoplasmic reticulum unfolded protein response (GO:0030968)3.68320255
50COPII vesicle coating (GO:0048208)3.64284304
51cilium or flagellum-dependent cell motility (GO:0001539)3.64262205
52detection of light stimulus involved in visual perception (GO:0050908)3.63023706
53detection of light stimulus involved in sensory perception (GO:0050962)3.63023706
54protein K11-linked deubiquitination (GO:0035871)3.62393523
55neural tube formation (GO:0001841)3.55147016
56cellular response to unfolded protein (GO:0034620)3.54447176
57peptide catabolic process (GO:0043171)3.53889343
58pyrimidine-containing compound transmembrane transport (GO:0072531)3.51382318
59bundle of His cell to Purkinje myocyte communication (GO:0086069)3.51247143
60regulation of natural killer cell differentiation (GO:0032823)3.46367237
61positive regulation of growth hormone secretion (GO:0060124)3.43008532
62response to endoplasmic reticulum stress (GO:0034976)3.42628360
63ER-nucleus signaling pathway (GO:0006984)3.39603905
64angiotensin maturation (GO:0002003)3.39358479
65positive regulation of catenin import into nucleus (GO:0035413)3.38165222
66retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.31925780
67gamma-aminobutyric acid transport (GO:0015812)3.31517799
68indole-containing compound metabolic process (GO:0042430)3.31483450
69ketone body metabolic process (GO:1902224)3.27854708
70regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.26225617
71intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.20985460
72cellular response to topologically incorrect protein (GO:0035967)3.19640742
73protein K48-linked deubiquitination (GO:0071108)3.19273945
74vitamin transmembrane transport (GO:0035461)3.18455440
75reflex (GO:0060004)3.17670509
76sulfur amino acid catabolic process (GO:0000098)3.17409879
77ERK1 and ERK2 cascade (GO:0070371)3.15731883
78transcytosis (GO:0045056)3.13013516
79photoreceptor cell maintenance (GO:0045494)3.06216778
80protein K63-linked deubiquitination (GO:0070536)3.05148548
81peptide cross-linking (GO:0018149)2.99807383
82positive regulation of defense response to virus by host (GO:0002230)2.97630733
83regulation of steroid hormone secretion (GO:2000831)2.97230473
84hexose catabolic process (GO:0019320)2.95714765
85regulation of hippo signaling (GO:0035330)2.95187720
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94911507
87tachykinin receptor signaling pathway (GO:0007217)2.93668584
88snRNA transcription (GO:0009301)2.93486935
89positive regulation of glycoprotein metabolic process (GO:1903020)2.92187052
90negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.91329646
91amine catabolic process (GO:0009310)2.90777203
92cellular biogenic amine catabolic process (GO:0042402)2.90777203
93monoubiquitinated protein deubiquitination (GO:0035520)2.90694683
94negative regulation of mast cell activation (GO:0033004)2.89840492
95primary amino compound metabolic process (GO:1901160)2.89391952
96potassium ion homeostasis (GO:0055075)2.87585377
97protein N-linked glycosylation via asparagine (GO:0018279)2.86507450
98cAMP catabolic process (GO:0006198)2.86331482
99peptidyl-asparagine modification (GO:0018196)2.84552229
100regulation of growth hormone secretion (GO:0060123)2.84166507
101auditory receptor cell stereocilium organization (GO:0060088)2.84032211
102branching involved in mammary gland duct morphogenesis (GO:0060444)2.82687201
103negative regulation of cytosolic calcium ion concentration (GO:0051481)2.82453350
104NAD biosynthetic process (GO:0009435)2.82309113
105vesicle coating (GO:0006901)2.81967807
106axoneme assembly (GO:0035082)2.81068004
107regulation of memory T cell differentiation (GO:0043380)2.80270063
108serotonin metabolic process (GO:0042428)2.79935332
109benzene-containing compound metabolic process (GO:0042537)2.78621917
110response to unfolded protein (GO:0006986)2.77645290
111behavioral response to ethanol (GO:0048149)2.77225272
112lung cell differentiation (GO:0060479)2.74808952
113negative regulation of calcium ion transport into cytosol (GO:0010523)2.74483350
114calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.73821066
115glandular epithelial cell differentiation (GO:0002067)2.73657872
116interferon-gamma production (GO:0032609)2.73225556
117DNA deamination (GO:0045006)2.71994239
118interkinetic nuclear migration (GO:0022027)2.70953971
119beta-amyloid metabolic process (GO:0050435)2.70952730
120cytoskeletal anchoring at plasma membrane (GO:0007016)2.70832911
121multicellular organismal catabolic process (GO:0044243)2.69033986
122multicellular organismal macromolecule metabolic process (GO:0044259)2.68697876
123sequestering of metal ion (GO:0051238)2.67632463
124nucleotide-sugar metabolic process (GO:0009225)2.67324719
125nucleotide-sugar biosynthetic process (GO:0009226)2.66425653
126protein targeting to Golgi (GO:0000042)2.65988080
127positive regulation of glycoprotein biosynthetic process (GO:0010560)2.65976780
128insulin-like growth factor receptor signaling pathway (GO:0048009)2.63570517
129positive regulation of developmental pigmentation (GO:0048087)2.63546804
130galactose metabolic process (GO:0006012)2.62941173
131cellular response to interferon-alpha (GO:0035457)2.62884638
132lung epithelial cell differentiation (GO:0060487)2.62335942
133positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.61498871
134fucosylation (GO:0036065)2.61481772
1352-oxoglutarate metabolic process (GO:0006103)2.61354054
136aromatic amino acid family catabolic process (GO:0009074)2.61261726
137cellular response to ATP (GO:0071318)2.60984564
138drug catabolic process (GO:0042737)2.60849166
139protein N-linked glycosylation (GO:0006487)2.60366878
140thyroid hormone metabolic process (GO:0042403)2.60359855
141collagen catabolic process (GO:0030574)2.60092042
142zinc ion transport (GO:0006829)2.59574985
143rRNA catabolic process (GO:0016075)2.59515915
144cell adhesion mediated by integrin (GO:0033627)2.58549119
145protein autoprocessing (GO:0016540)2.57627253
146defense response to Gram-negative bacterium (GO:0050829)2.57608068
147cyclic nucleotide catabolic process (GO:0009214)2.57325011
148regulation of membrane protein ectodomain proteolysis (GO:0051043)2.57170368
149collagen metabolic process (GO:0032963)2.56432731
150lipid translocation (GO:0034204)2.56387214
151phospholipid translocation (GO:0045332)2.56387214
152protein polyglutamylation (GO:0018095)2.56296104
153activated T cell proliferation (GO:0050798)2.56115678
154oxidative demethylation (GO:0070989)2.55182372
155detection of mechanical stimulus involved in sensory perception (GO:0050974)2.55130907
156nonmotile primary cilium assembly (GO:0035058)2.54812282
157response to topologically incorrect protein (GO:0035966)2.54744222
158neuronal action potential (GO:0019228)2.54187551
159hypotonic response (GO:0006971)2.54182614
160branched-chain amino acid metabolic process (GO:0009081)2.53730663
161multicellular organismal metabolic process (GO:0044236)2.53573943
162negative regulation of cAMP-mediated signaling (GO:0043951)2.52654610
163positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.51919729
164adaptation of signaling pathway (GO:0023058)2.50139136
165regulation of establishment of cell polarity (GO:2000114)2.48684479
166retrograde transport, vesicle recycling within Golgi (GO:0000301)2.48665776
167sulfation (GO:0051923)2.47187972
168rhodopsin mediated signaling pathway (GO:0016056)2.43998488
169negative regulation of systemic arterial blood pressure (GO:0003085)2.43893620
170regulation of rhodopsin mediated signaling pathway (GO:0022400)2.43885093
171multicellular organism reproduction (GO:0032504)2.42961398
172regulation of sarcomere organization (GO:0060297)2.42260426
173startle response (GO:0001964)2.41465770
174cilium organization (GO:0044782)2.39816945
175regulation of B cell receptor signaling pathway (GO:0050855)2.39731015
176cilium movement (GO:0003341)2.38756025
177aromatic amino acid family metabolic process (GO:0009072)2.38696499
178inner ear receptor stereocilium organization (GO:0060122)2.38505863
179negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.37269439
180negative regulation of translation, ncRNA-mediated (GO:0040033)2.37269439
181regulation of translation, ncRNA-mediated (GO:0045974)2.37269439
182cilium assembly (GO:0042384)2.37168382
183phosphatidylinositol acyl-chain remodeling (GO:0036149)2.36642777
184membrane depolarization during action potential (GO:0086010)2.35962506
185DNA methylation involved in gamete generation (GO:0043046)2.34602388
186alkaloid metabolic process (GO:0009820)2.33872251
187regulation of action potential (GO:0098900)2.33463601
188regulation of gene silencing by miRNA (GO:0060964)2.32378788
189regulation of gene silencing by RNA (GO:0060966)2.32378788
190regulation of posttranscriptional gene silencing (GO:0060147)2.32378788
191regulation of pigment cell differentiation (GO:0050932)2.32289978
192dopamine transport (GO:0015872)2.31287715
193histone H3-K9 methylation (GO:0051567)2.31075134
194proline transport (GO:0015824)2.30974515
195retinal cone cell development (GO:0046549)2.29200026
196piRNA metabolic process (GO:0034587)2.28169727
197cellular response to sterol (GO:0036315)2.27979076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.95445092
2GBX2_23144817_ChIP-Seq_PC3_Human3.45116349
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.40279337
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.31884293
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.05812753
6ZNF274_21170338_ChIP-Seq_K562_Hela2.91452843
7VDR_22108803_ChIP-Seq_LS180_Human2.86214864
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.78475742
9EZH2_22144423_ChIP-Seq_EOC_Human2.76929754
10STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.68400436
11SOX2_27498859_Chip-Seq_STOMACH_Mouse2.64360776
12CLOCK_20551151_ChIP-Seq_293T_Human2.63461384
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.60997585
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56091935
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53693557
16IGF1R_20145208_ChIP-Seq_DFB_Human2.45286409
17ZNF217_24962896_ChIP-Seq_MCF-7_Human2.41742619
18SOX2_20726797_ChIP-Seq_SW620_Human2.41296205
19FOXO3_23340844_ChIP-Seq_DLD1_Human2.39522412
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39350750
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.36462372
22ZNF263_19887448_ChIP-Seq_K562_Human2.32360265
23ESR1_20079471_ChIP-ChIP_T-47D_Human2.29470069
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28340402
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23985310
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23123062
27TAF15_26573619_Chip-Seq_HEK293_Human2.08069290
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.07467060
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.07467060
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.06610310
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.06568187
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.01667176
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.01667176
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.01667176
35AHR_22903824_ChIP-Seq_MCF-7_Human2.01380788
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01093825
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00144412
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.96374456
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.93520367
40ER_23166858_ChIP-Seq_MCF-7_Human1.93165941
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.92181227
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90088327
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86748527
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86505085
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.86146004
46P300_19829295_ChIP-Seq_ESCs_Human1.85308136
47FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.84499005
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84448399
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79827455
50STAT3_23295773_ChIP-Seq_U87_Human1.76462986
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.75785955
52GATA4_25053715_ChIP-Seq_YYC3_Human1.74753350
53BCAT_22108803_ChIP-Seq_LS180_Human1.74545067
54GATA6_25053715_ChIP-Seq_YYC3_Human1.72911133
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.71053252
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70651911
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69752772
58SMAD4_21799915_ChIP-Seq_A2780_Human1.67752596
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66055719
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65676295
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.65557340
62TCF4_23295773_ChIP-Seq_U87_Human1.62195609
63EWS_26573619_Chip-Seq_HEK293_Human1.61635565
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61235864
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.60597176
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.59109134
67FUS_26573619_Chip-Seq_HEK293_Human1.58483888
68CJUN_26792858_Chip-Seq_BT549_Human1.57946521
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57500546
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55237208
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55059143
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54462677
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.53052037
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52659800
75GATA3_24758297_ChIP-Seq_MCF-7_Human1.51623679
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51502100
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.51409670
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50390887
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50270494
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50221033
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.47934399
82CDX2_20551321_ChIP-Seq_CACO-2_Human1.47743320
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47730659
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47730659
85AR_25329375_ChIP-Seq_VCAP_Human1.46617424
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45687904
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45687904
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44824446
89CBP_20019798_ChIP-Seq_JUKART_Human1.43852943
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43852943
91LXR_22158963_ChIP-Seq_LIVER_Mouse1.40994391
92AR_21572438_ChIP-Seq_LNCaP_Human1.40877508
93DROSHA_22980978_ChIP-Seq_HELA_Human1.39053811
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.38958063
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38617918
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.38296621
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38163878
98PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37162587
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34764017
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.34154726
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.33933070
102TP53_16413492_ChIP-PET_HCT116_Human1.33771532
103IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32488439
104RACK7_27058665_Chip-Seq_MCF-7_Human1.31214695
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30353912
106REST_21632747_ChIP-Seq_MESCs_Mouse1.29973302
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.28944753
108TCF4_22108803_ChIP-Seq_LS180_Human1.28761637
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28518561
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.27193712
111ATF3_27146783_Chip-Seq_COLON_Human1.26985285
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.26735808
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26118846
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25627197
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.25179685
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24445235
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.24186845
118RUNX2_22187159_ChIP-Seq_PCA_Human1.23557177
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23333049
120CHD1_26751641_Chip-Seq_LNCaP_Human1.21726048
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21284696
122FOXA2_19822575_ChIP-Seq_HepG2_Human1.20925011
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20683655
124SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20668491
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20250645
126RXR_22158963_ChIP-Seq_LIVER_Mouse1.19597624
127GATA1_22025678_ChIP-Seq_K562_Human1.19268433
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19073107
129IRF1_19129219_ChIP-ChIP_H3396_Human1.18350124
130NANOG_19829295_ChIP-Seq_ESCs_Human1.18164152
131SOX2_19829295_ChIP-Seq_ESCs_Human1.18164152
132TP53_22573176_ChIP-Seq_HFKS_Human1.17780752
133FOXA1_25552417_ChIP-Seq_VCAP_Human1.17336254
134CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17263371
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.17151690
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16731719
137MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16205235
138PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16040845
139SALL1_21062744_ChIP-ChIP_HESCs_Human1.15341574
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14766869
141NANOG_18555785_Chip-Seq_ESCs_Mouse1.13407287
142CRX_20693478_ChIP-Seq_RETINA_Mouse1.12306410
143KLF5_25053715_ChIP-Seq_YYC3_Human1.12257252
144SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12102049
145CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11692757
146RXR_22108803_ChIP-Seq_LS180_Human1.11588252
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11369075
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11156003
149TBX20_22080862_ChIP-Seq_HEART_Mouse1.11147991
150TBX20_22328084_ChIP-Seq_HEART_Mouse1.11147991
151RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11115862
152TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10621655
153FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10448173
154KDM2B_26808549_Chip-Seq_REH_Human1.09546452
155KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09173478
156TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08106454
157CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07930856
158RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07462926
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07446824
160TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06423130
161TP63_23658742_ChIP-Seq_EP156T_Human1.06010125
162CDX2_22108803_ChIP-Seq_LS180_Human1.05941822
163OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05889888
164PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05521196
165ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05500416
166P53_22387025_ChIP-Seq_ESCs_Mouse1.05243809
167SOX2_21211035_ChIP-Seq_LN229_Gbm1.04945349
168P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04786474
169RUNX_20019798_ChIP-Seq_JUKART_Human1.03580469
170CBX2_27304074_Chip-Seq_ESCs_Mouse1.02855796
171FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02385581
172FOXA1_25329375_ChIP-Seq_VCAP_Human1.02385581
173KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01388547
174BRD4_25478319_ChIP-Seq_HGPS_Human1.00897521
175GATA3_21878914_ChIP-Seq_MCF-7_Human1.00491160
176ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00236194
177E2F1_18555785_Chip-Seq_ESCs_Mouse0.99885732
178RNF2_27304074_Chip-Seq_NSC_Mouse0.98942922
179ISL1_27105846_Chip-Seq_CPCs_Mouse0.98899996
180AR_21909140_ChIP-Seq_LNCAP_Human0.98080924
181PIAS1_25552417_ChIP-Seq_VCAP_Human0.98031425
182SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97777834
183TP53_22127205_ChIP-Seq_IMR90_Human0.97165591
184CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96607897
185CREB1_26743006_Chip-Seq_LNCaP_Human0.95787601
186FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93688731
187ELF5_23300383_ChIP-Seq_T47D_Human0.89968554
188P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88600981
189JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86159255
190UBF1/2_26484160_Chip-Seq_HMECs_Human0.86134354
191PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85857657
192WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85581395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.39476266
2MP0003300_gastrointestinal_ulcer4.50969166
3MP0005310_abnormal_salivary_gland4.47680959
4MP0002254_reproductive_system_inflammat4.26746215
5MP0002166_altered_tumor_susceptibility4.03718475
6MP0000569_abnormal_digit_pigmentation3.47423250
7MP0003195_calcinosis3.34941778
8MP0005647_abnormal_sex_gland3.01655665
9MP0002006_tumorigenesis3.01123361
10MP0001346_abnormal_lacrimal_gland2.97448508
11MP0003705_abnormal_hypodermis_morpholog2.90552664
12MP0000537_abnormal_urethra_morphology2.89229402
13MP0001873_stomach_inflammation2.73552514
14MP0000613_abnormal_salivary_gland2.71345799
15MP0001501_abnormal_sleep_pattern2.64836923
16MP0005275_abnormal_skin_tensile2.58488375
17MP0010386_abnormal_urinary_bladder2.55064595
18MP0008438_abnormal_cutaneous_collagen2.51701119
19MP0003646_muscle_fatigue2.50640868
20MP0002138_abnormal_hepatobiliary_system2.47291469
21MP0005551_abnormal_eye_electrophysiolog2.34183377
22MP0008877_abnormal_DNA_methylation2.26204504
23MP0009046_muscle_twitch2.24643249
24MP0002876_abnormal_thyroid_physiology2.23823324
25MP0001968_abnormal_touch/_nociception2.15503637
26MP0004264_abnormal_extraembryonic_tissu2.09407994
27MP0010352_gastrointestinal_tract_polyps2.08728018
28MP0002009_preneoplasia2.02115243
29MP0009745_abnormal_behavioral_response1.97988356
30MP0010678_abnormal_skin_adnexa1.97978087
31MP0004142_abnormal_muscle_tone1.95916701
32MP0002837_dystrophic_cardiac_calcinosis1.93724226
33MP0008872_abnormal_physiological_respon1.84608638
34MP0005671_abnormal_response_to1.76273947
35MP0006276_abnormal_autonomic_nervous1.74451801
36MP0005645_abnormal_hypothalamus_physiol1.72672712
37MP0008057_abnormal_DNA_replication1.70737793
38MP0002736_abnormal_nociception_after1.68341581
39MP0002796_impaired_skin_barrier1.67361448
40MP0002060_abnormal_skin_morphology1.66771525
41MP0003566_abnormal_cell_adhesion1.66574633
42MP0005167_abnormal_blood-brain_barrier1.64692519
43MP0001348_abnormal_lacrimal_gland1.63445676
44MP0001881_abnormal_mammary_gland1.63075271
45MP0000538_abnormal_urinary_bladder1.61940166
46MP0003787_abnormal_imprinting1.58468642
47MP0000566_synostosis1.57261737
48MP0009384_cardiac_valve_regurgitation1.55513510
49MP0005253_abnormal_eye_physiology1.55193101
50MP0002638_abnormal_pupillary_reflex1.54754480
51MP0004272_abnormal_basement_membrane1.54590749
52MP0009780_abnormal_chondrocyte_physiolo1.54006447
53MP0005023_abnormal_wound_healing1.52712975
54MP0002272_abnormal_nervous_system1.50251859
55MP0002928_abnormal_bile_duct1.49334508
56MP0009764_decreased_sensitivity_to1.48905211
57MP0005174_abnormal_tail_pigmentation1.44963472
58MP0005646_abnormal_pituitary_gland1.44844792
59MP0001986_abnormal_taste_sensitivity1.44757981
60MP0003763_abnormal_thymus_physiology1.44283090
61MP0000372_irregular_coat_pigmentation1.42434624
62MP0006054_spinal_hemorrhage1.41283581
63MP0001765_abnormal_ion_homeostasis1.37431812
64MP0002295_abnormal_pulmonary_circulatio1.37200857
65MP0004043_abnormal_pH_regulation1.34905868
66MP0001970_abnormal_pain_threshold1.34222338
67MP0002064_seizures1.33494633
68MP0002102_abnormal_ear_morphology1.33370842
69MP0001756_abnormal_urination1.32431242
70MP0000516_abnormal_urinary_system1.32012231
71MP0005367_renal/urinary_system_phenotyp1.32012231
72MP0002693_abnormal_pancreas_physiology1.32006133
73MP0001299_abnormal_eye_distance/1.30557692
74MP0008961_abnormal_basal_metabolism1.29830771
75MP0002733_abnormal_thermal_nociception1.29810755
76MP0003045_fibrosis1.29716947
77MP0002098_abnormal_vibrissa_morphology1.29713943
78MP0003453_abnormal_keratinocyte_physiol1.27556285
79MP0002735_abnormal_chemical_nociception1.27532318
80MP0001800_abnormal_humoral_immune1.27055308
81MP0004130_abnormal_muscle_cell1.26730897
82MP0002572_abnormal_emotion/affect_behav1.25636049
83MP0004742_abnormal_vestibular_system1.25443849
84MP0000627_abnormal_mammary_gland1.24305144
85MP0001919_abnormal_reproductive_system1.23047526
86MP0003252_abnormal_bile_duct1.19472072
87MP0001486_abnormal_startle_reflex1.19255889
88MP0001485_abnormal_pinna_reflex1.18737384
89MP0003941_abnormal_skin_development1.15428263
90MP0010155_abnormal_intestine_physiology1.14682535
91MP0002067_abnormal_sensory_capabilities1.14590067
92MP0004145_abnormal_muscle_electrophysio1.14383989
93MP0005085_abnormal_gallbladder_physiolo1.14272840
94MP0000383_abnormal_hair_follicle1.12191422
95MP0006072_abnormal_retinal_apoptosis1.12075041
96MP0005389_reproductive_system_phenotype1.12066607
97MP0000534_abnormal_ureter_morphology1.11758707
98MP0000230_abnormal_systemic_arterial1.11467264
99MP0000377_abnormal_hair_follicle1.11056096
100MP0000631_abnormal_neuroendocrine_gland1.10874826
101MP0003136_yellow_coat_color1.10774776
102MP0002557_abnormal_social/conspecific_i1.10259954
103MP0003950_abnormal_plasma_membrane1.09657558
104MP0004147_increased_porphyrin_level1.07895108
105MP0000762_abnormal_tongue_morphology1.07103632
106MP0002168_other_aberrant_phenotype1.05880807
107MP0003866_abnormal_defecation1.05260122
108MP0004924_abnormal_behavior1.03927171
109MP0005386_behavior/neurological_phenoty1.03927171
110MP0005076_abnormal_cell_differentiation1.03839728
111MP0003724_increased_susceptibility_to1.03284234
112MP0001216_abnormal_epidermal_layer1.03262414
113MP0005387_immune_system_phenotype1.02870760
114MP0001790_abnormal_immune_system1.02870760
115MP0001440_abnormal_grooming_behavior1.02287688
116MP0005410_abnormal_fertilization1.02130490
117MP0003635_abnormal_synaptic_transmissio1.01531297
118MP0003011_delayed_dark_adaptation1.00763493
119MP0002896_abnormal_bone_mineralization0.99469974
120MP0005266_abnormal_metabolism0.98637642
121MP0005503_abnormal_tendon_morphology0.97705343
122MP0000427_abnormal_hair_cycle0.97077013
123MP0004381_abnormal_hair_follicle0.96090357
124MP0009643_abnormal_urine_homeostasis0.95139255
125MP0005075_abnormal_melanosome_morpholog0.94919851
126MP0002063_abnormal_learning/memory/cond0.94665853
127MP0009765_abnormal_xenobiotic_induced0.93750170
128MP0002229_neurodegeneration0.91819657
129MP0000579_abnormal_nail_morphology0.91713171
130MP0002132_abnormal_respiratory_system0.91268509
131MP0000462_abnormal_digestive_system0.89781504
132MP0002095_abnormal_skin_pigmentation0.89737487
133MP0002723_abnormal_immune_serum0.88332343
134MP0008875_abnormal_xenobiotic_pharmacok0.87916761
135MP0001835_abnormal_antigen_presentation0.87654204
136MP0000685_abnormal_immune_system0.87308569
137MP0003633_abnormal_nervous_system0.86940532
138MP0000467_abnormal_esophagus_morphology0.85179794
139MP0003183_abnormal_peptide_metabolism0.85011063
140MP0005501_abnormal_skin_physiology0.84018328
141MP0005448_abnormal_energy_balance0.84015173
142MP0002160_abnormal_reproductive_system0.83171798
143MP0000767_abnormal_smooth_muscle0.82551938
144MP0004947_skin_inflammation0.82470258
145MP0003656_abnormal_erythrocyte_physiolo0.81761161
146MP0004133_heterotaxia0.80356174
147MP0004185_abnormal_adipocyte_glucose0.79783869
148MP0004885_abnormal_endolymph0.79660525
149MP0003091_abnormal_cell_migration0.79292812
150MP0005220_abnormal_exocrine_pancreas0.79064147
151MP0002136_abnormal_kidney_physiology0.78987983
152MP0001984_abnormal_olfaction0.78813918
153MP0003315_abnormal_perineum_morphology0.78691284
154MP0010329_abnormal_lipoprotein_level0.78657470
155MP0002111_abnormal_tail_morphology0.78489491
156MP0005379_endocrine/exocrine_gland_phen0.77703639
157MP0005636_abnormal_mineral_homeostasis0.76788888
158MP0000470_abnormal_stomach_morphology0.76258148
159MP0002653_abnormal_ependyma_morphology0.75221891
160MP0004134_abnormal_chest_morphology0.74704230
161MP0010771_integument_phenotype0.74555016
162MP0002148_abnormal_hypersensitivity_rea0.74172040
163MP0000681_abnormal_thyroid_gland0.74168634
164MP0002938_white_spotting0.73940625
165MP0002163_abnormal_gland_morphology0.73173923
166MP0005381_digestive/alimentary_phenotyp0.72531558
167MP0000477_abnormal_intestine_morphology0.71521048
168MP0005166_decreased_susceptibility_to0.68854136
169MP0002277_abnormal_respiratory_mucosa0.68081830
170MP0009053_abnormal_anal_canal0.66591339
171MP0000733_abnormal_muscle_development0.66283515
172MP0001663_abnormal_digestive_system0.65851406
173MP0002139_abnormal_hepatobiliary_system0.64815961
174MP0003937_abnormal_limbs/digits/tail_de0.63798879
175MP0003936_abnormal_reproductive_system0.63248869
176MP0002877_abnormal_melanocyte_morpholog0.62991066
177MP0001849_ear_inflammation0.62333721
178MP0003638_abnormal_response/metabolism_0.62280142
179MP0000163_abnormal_cartilage_morphology0.61433324
180MP0000750_abnormal_muscle_regeneration0.60728932
181MP0002396_abnormal_hematopoietic_system0.59894074
182MP0000343_altered_response_to0.56931743
183MP0001958_emphysema0.55132984
184MP0000647_abnormal_sebaceous_gland0.54948178
185MP0002135_abnormal_kidney_morphology0.54537943
186MP0001666_abnormal_nutrient_absorption0.53999495

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)5.98865490
2Pancreatic cysts (HP:0001737)4.87369965
3Right ventricular cardiomyopathy (HP:0011663)4.52810016
4Molar tooth sign on MRI (HP:0002419)4.21935176
5Abnormality of midbrain morphology (HP:0002418)4.21935176
6Aortic aneurysm (HP:0004942)4.19528064
7Pancreatic fibrosis (HP:0100732)4.17443265
8Congenital stationary night blindness (HP:0007642)4.10877770
9Morphological abnormality of the inner ear (HP:0011390)4.01194844
10True hermaphroditism (HP:0010459)3.98209734
11Genetic anticipation (HP:0003743)3.96134603
12Hyperventilation (HP:0002883)3.84173075
13Atrophic scars (HP:0001075)3.77560911
14Nephronophthisis (HP:0000090)3.76768773
15Chronic hepatic failure (HP:0100626)3.74824804
16Pili torti (HP:0003777)3.63681094
17Progressive cerebellar ataxia (HP:0002073)3.60802859
18Aortic dissection (HP:0002647)3.58068633
19Onycholysis (HP:0001806)3.55521528
20Attenuation of retinal blood vessels (HP:0007843)3.55266202
21Milia (HP:0001056)3.49102400
22Rectal prolapse (HP:0002035)3.48637954
23Abnormality of the renal cortex (HP:0011035)3.46436303
24Gaze-evoked nystagmus (HP:0000640)3.44013535
25Abnormality of the renal medulla (HP:0100957)3.41307974
26Clumsiness (HP:0002312)3.14328115
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.10119464
28Cystic liver disease (HP:0006706)3.09384468
29Protruding tongue (HP:0010808)2.99788613
30Hydroxyprolinuria (HP:0003080)2.98983268
31Abnormality of proline metabolism (HP:0010907)2.98983268
32Lip pit (HP:0100267)2.96739726
33Congenital sensorineural hearing impairment (HP:0008527)2.94963058
34Subcapsular cataract (HP:0000523)2.92898028
35Aplasia involving bones of the extremities (HP:0009825)2.89929012
36Aplasia involving bones of the upper limbs (HP:0009823)2.89929012
37Aplasia of the phalanges of the hand (HP:0009802)2.89929012
38Abolished electroretinogram (ERG) (HP:0000550)2.89441527
39Decreased circulating renin level (HP:0003351)2.87644233
40Medial flaring of the eyebrow (HP:0010747)2.86118919
41Large for gestational age (HP:0001520)2.83311368
42Progressive inability to walk (HP:0002505)2.81331743
43Abnormality of the intrinsic pathway (HP:0010989)2.81032266
44Inability to walk (HP:0002540)2.75669689
45Vacuolated lymphocytes (HP:0001922)2.71886196
46Furrowed tongue (HP:0000221)2.69338183
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.68106942
48Abnormality of the 2nd finger (HP:0004100)2.65614283
49Facial shape deformation (HP:0011334)2.62827351
50Potter facies (HP:0002009)2.62827351
51Plantar hyperkeratosis (HP:0007556)2.62145757
52Stomatitis (HP:0010280)2.61853680
53Abnormal hair laboratory examination (HP:0003328)2.60980448
54Fair hair (HP:0002286)2.60924354
55Bony spicule pigmentary retinopathy (HP:0007737)2.60854541
56Hypoplasia of the uterus (HP:0000013)2.52686392
57Abnormality of the axillary hair (HP:0100134)2.52371055
58Abnormality of secondary sexual hair (HP:0009888)2.52371055
59Tubular atrophy (HP:0000092)2.51320276
60Abnormal biliary tract physiology (HP:0012439)2.50979016
61Bile duct proliferation (HP:0001408)2.50979016
62Abnormal drinking behavior (HP:0030082)2.48251530
63Polydipsia (HP:0001959)2.48251530
64Febrile seizures (HP:0002373)2.47129283
65Congenital hepatic fibrosis (HP:0002612)2.43544068
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.42144951
67Woolly hair (HP:0002224)2.41808008
68Abnormality of alanine metabolism (HP:0010916)2.41717219
69Hyperalaninemia (HP:0003348)2.41717219
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41717219
71Renal cortical cysts (HP:0000803)2.38417895
72Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36763146
73Hematochezia (HP:0002573)2.36651503
74Absent speech (HP:0001344)2.35866940
75Abnormal rod and cone electroretinograms (HP:0008323)2.35466711
76Aneurysm (HP:0002617)2.34381520
77Keratoconus (HP:0000563)2.34187717
78Increased corneal curvature (HP:0100692)2.34187717
79Stomach cancer (HP:0012126)2.31527126
80Fragile skin (HP:0001030)2.31286905
81Fibular aplasia (HP:0002990)2.26885918
82Hyperglycinuria (HP:0003108)2.26376452
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.26110632
84Osteolytic defects of the hand bones (HP:0009699)2.26110632
85Achilles tendon contracture (HP:0001771)2.23777327
86Type II lissencephaly (HP:0007260)2.23476590
87Ankle contracture (HP:0006466)2.22815425
88Aplasia/Hypoplasia of the tongue (HP:0010295)2.22063114
89Generalized hypopigmentation of hair (HP:0011358)2.21471471
90Gait imbalance (HP:0002141)2.20704431
91Cervical subluxation (HP:0003308)2.20637964
92Short hallux (HP:0010109)2.20103155
93Hypoplastic nipples (HP:0002557)2.18268719
94Decreased central vision (HP:0007663)2.17759639
95Abnormality of the gastric mucosa (HP:0004295)2.17479624
96Dialeptic seizures (HP:0011146)2.17098916
97Thrombocytosis (HP:0001894)2.16729591
98Beaking of vertebral bodies (HP:0004568)2.14105349
99Broad-based gait (HP:0002136)2.13904207
100Premature rupture of membranes (HP:0001788)2.13331443
101Sclerocornea (HP:0000647)2.11341033
102Congenital primary aphakia (HP:0007707)2.09810064
103Abnormal foot bone ossification (HP:0010675)2.09243646
104Widely patent fontanelles and sutures (HP:0004492)2.08775328
105Mildly elevated creatine phosphokinase (HP:0008180)2.08534009
106Widely spaced teeth (HP:0000687)2.07943688
107Nephrogenic diabetes insipidus (HP:0009806)2.07421731
108Thoracolumbar scoliosis (HP:0002944)2.07379000
109Fragile nails (HP:0001808)2.07121210
110Abnormal delayed hypersensitivity skin test (HP:0002963)2.04397176
111Anencephaly (HP:0002323)2.03875961
112Focal seizures (HP:0007359)2.03719461
113Mucopolysacchariduria (HP:0008155)2.03199861
114Urinary glycosaminoglycan excretion (HP:0003541)2.03199861
115Cerebral aneurysm (HP:0004944)2.03167167
116Natal tooth (HP:0000695)2.01983892
117Wormian bones (HP:0002645)2.01493186
118Sparse lateral eyebrow (HP:0005338)2.01467455
119Abnormality of the Achilles tendon (HP:0005109)2.01465717
120Subacute progressive viral hepatitis (HP:0006572)2.00345468
121Radial bowing (HP:0002986)2.00244934
122Scapular winging (HP:0003691)2.00094435
123Aplasia/Hypoplasia of the hallux (HP:0008362)1.99981830
124Ketoacidosis (HP:0001993)1.98943113
125Constricted visual fields (HP:0001133)1.98896864
126Back pain (HP:0003418)1.98202888
127Hyporeflexia of lower limbs (HP:0002600)1.97849929
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96869087
129Hand muscle atrophy (HP:0009130)1.96245868
130Abnormality of macular pigmentation (HP:0008002)1.94506269
131Shallow orbits (HP:0000586)1.94048086
132Hypoplastic labia majora (HP:0000059)1.94039048
133Ureteral stenosis (HP:0000071)1.93519430
134Ketosis (HP:0001946)1.92996985
135Pterygium (HP:0001059)1.92007056
136Biliary tract neoplasm (HP:0100574)1.91940779
137Abnormal ciliary motility (HP:0012262)1.91273627
138Distal upper limb amyotrophy (HP:0007149)1.90043193
139Upper limb amyotrophy (HP:0009129)1.90043193
140Increased cerebral lipofuscin (HP:0011813)1.88739143
141Protrusio acetabuli (HP:0003179)1.88712254
142IgG deficiency (HP:0004315)1.88284689
143Advanced eruption of teeth (HP:0006288)1.88200061
144Micronodular cirrhosis (HP:0001413)1.87757410
145Hypoplastic ischia (HP:0003175)1.87612332
146Hypoplasia of dental enamel (HP:0006297)1.87598441
147Ureteral obstruction (HP:0006000)1.86806766
148Hypothermia (HP:0002045)1.86195097
149Type 1 muscle fiber predominance (HP:0003803)1.86171278
150Congenital, generalized hypertrichosis (HP:0004540)1.85874413
151Shawl scrotum (HP:0000049)1.84834342
152Coxa valga (HP:0002673)1.84250118
153Polyuria (HP:0000103)1.83919516
154Lissencephaly (HP:0001339)1.83579642
155Palmoplantar hyperkeratosis (HP:0000972)1.82975185
156Abdominal distention (HP:0003270)1.82934876
157Abnormality of the proximal phalanges of the hand (HP:0009834)1.82492388
158Curly hair (HP:0002212)1.82349674
159Absence seizures (HP:0002121)1.81643455
160Distal arthrogryposis (HP:0005684)1.80348280
161Male pseudohermaphroditism (HP:0000037)1.79398267
162Central scotoma (HP:0000603)1.79254040
163Abnormality of T cell number (HP:0011839)1.78309232
164Thyroiditis (HP:0100646)1.78261254
165Retrobulbar optic neuritis (HP:0100654)1.77963642
166Optic neuritis (HP:0100653)1.77963642
167Hypoalbuminemia (HP:0003073)1.77740731
168Abnormal albumin level (HP:0012116)1.77740731
169Aplasia/Hypoplasia of the fovea (HP:0008060)1.77723457
170Hypoplasia of the fovea (HP:0007750)1.77723457
171Abnormality of the pons (HP:0007361)1.75796192
172Polar cataract (HP:0010696)1.75646345
173Cerebellar dysplasia (HP:0007033)1.75597738
174Hypoplasia of the ulna (HP:0003022)1.75402917
175Pendular nystagmus (HP:0012043)1.75394228
176Absent/shortened dynein arms (HP:0200106)1.74815770
177Dynein arm defect of respiratory motile cilia (HP:0012255)1.74815770
178Retinitis pigmentosa (HP:0000510)1.74659327
179Male infertility (HP:0003251)1.74529075
180Microretrognathia (HP:0000308)1.74388870
181Mitral valve prolapse (HP:0001634)1.74225063
182Wide cranial sutures (HP:0010537)1.73631155
183Tarsal synostosis (HP:0008368)1.73578718
184Abnormality of polysaccharide metabolism (HP:0011012)1.73409827
185Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73409827
186Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73409827
187Colon cancer (HP:0003003)1.73408941
188Hypoplasia of the pons (HP:0012110)1.72902601
189Exocrine pancreatic insufficiency (HP:0001738)1.72841985
190Genital tract atresia (HP:0001827)1.72148536
191Severe visual impairment (HP:0001141)1.68444375
192Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67721078
193Abnormality of binocular vision (HP:0011514)1.67709605
194Diplopia (HP:0000651)1.67709605
195Thyroid-stimulating hormone excess (HP:0002925)1.65956078
196Hemiparesis (HP:0001269)1.65820330
197Patellar aplasia (HP:0006443)1.65701058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.93172225
2FRK4.82288069
3MST44.72367782
4LATS14.09526341
5ERN13.43839032
6ADRBK23.01334626
7ACVR1B2.98498880
8EEF2K2.81316109
9STK392.79025938
10SIK12.67648906
11EPHA22.45560118
12TXK2.44690248
13TAOK32.29240584
14SCYL22.24269816
15TTN2.14454167
16BCKDK2.08693674
17SIK22.08378576
18LMTK22.00041719
19NUAK11.96378183
20PTK61.87593649
21WNK31.81904660
22FER1.80228811
23MAPKAPK31.76226273
24MAP3K21.73282885
25RPS6KB21.65026353
26PDK21.63878239
27MAPK131.62626939
28MYLK1.62008626
29LRRK21.61361220
30PINK11.57637362
31MAP4K21.50645965
32DDR21.48727202
33CAMKK21.47960485
34DAPK21.47223141
35TRIB31.46552075
36NTRK31.43552850
37PDGFRA1.34586311
38MAP3K41.32654254
39PIK3CG1.32556575
40WNK41.26642141
41JAK31.25735893
42TEC1.22211646
43CASK1.21970790
44MST1R1.20469669
45ADRBK11.19637001
46RIPK11.17880082
47PIK3CA1.15901952
48STK101.15305441
49ITK1.12545551
50ZAK1.10505586
51PKN21.08836504
52OXSR11.07600687
53TNIK1.02138728
54PTK2B1.01127162
55MAP4K11.00034350
56MET0.99830610
57TRPM70.97008622
58IKBKB0.96500567
59STK30.96213134
60TESK10.96036007
61EPHB10.94217097
62IRAK10.93546831
63TLK10.91742094
64LATS20.91292042
65TNK20.90513662
66STK380.88467494
67PAK20.86535199
68PTK20.83993722
69MAP2K60.80775019
70NME10.80635763
71MAP3K140.78923940
72JAK10.78555190
73MAP3K30.78009262
74MKNK20.76629771
75PRKCE0.74326518
76EPHA30.74168842
77SGK20.71396558
78PRKCG0.71327189
79SYK0.71292995
80MARK30.69188042
81TYK20.68264764
82PRKCQ0.67734759
83JAK20.66180084
84DMPK0.66104724
85EPHB20.64646472
86TIE10.64031470
87MARK10.63189180
88STK38L0.62062712
89TGFBR10.61823118
90BLK0.59585106
91LCK0.58812333
92CAMK1D0.57885103
93CAMKK10.57819727
94MAP2K20.57766975
95PRKCI0.57494313
96RPS6KA20.56255237
97ROCK10.53933939
98TBK10.53617327
99MTOR0.53408400
100STK110.53272829
101BCR0.53235726
102BMX0.53006079
103ROCK20.52947595
104TRIM280.50344017
105FGFR20.50239826
106KIT0.49840766
107FGFR30.48252100
108MUSK0.47206504
109CAMK2A0.47005235
110PDGFRB0.46165231
111CHUK0.45718946
112CAMK10.45508596
113MAPKAPK50.44602139
114INSRR0.44586129
115SGK2230.43958041
116SGK4940.43958041
117RET0.43756762
118MAP3K70.43690592
119PRKAA10.43582265
120HCK0.43290873
121NTRK10.43108755
122PKN10.42888218
123DYRK1A0.42788872
124CAMK40.42396561
125MAP3K80.41782300
126FGFR40.40981939
127GRK70.39898531
128NTRK20.39752826
129RPS6KA50.38562675
130PHKG20.38553208
131PHKG10.38553208
132LYN0.38128208
133NEK60.37910195
134PRKCH0.36507740
135PRKCZ0.35696827
136PRKACA0.34859234
137MAP2K70.34646892
138NLK0.34622800
139TGFBR20.34603852
140MAPK110.33606650
141MELK0.33504986
142CDC42BPA0.33501672
143HIPK20.33134070
144TESK20.32244363
145ERBB20.31621736
146PDK30.30516563
147PDK40.30516563
148RPS6KA60.30033392
149IKBKE0.29942899
150FES0.29570357
151INSR0.25732135
152CAMK1G0.25501618
153MATK0.25425319
154EGFR0.24727666
155PRKAA20.24720470
156BTK0.23794026
157KSR20.23668386
158GRK10.22536093
159BMPR1B0.21762055
160RPS6KA10.21575731
161CSF1R0.21402839
162LIMK10.21319011
163PAK30.21245864
164FLT30.21184085
165DYRK1B0.21071436
166RPS6KA40.20868644

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.10325649
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.71871587
3Sulfur metabolism_Homo sapiens_hsa009203.70443576
4Phototransduction_Homo sapiens_hsa047442.70193136
5Linoleic acid metabolism_Homo sapiens_hsa005912.57203380
6Butanoate metabolism_Homo sapiens_hsa006502.51358026
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.44458226
8Protein export_Homo sapiens_hsa030602.43181761
9ECM-receptor interaction_Homo sapiens_hsa045122.22436335
10Nicotine addiction_Homo sapiens_hsa050332.18494712
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.16341789
12N-Glycan biosynthesis_Homo sapiens_hsa005102.09590123
13Nitrogen metabolism_Homo sapiens_hsa009102.09311347
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99739841
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.98875545
16Tryptophan metabolism_Homo sapiens_hsa003801.89604092
17Renin-angiotensin system_Homo sapiens_hsa046141.88803559
18Adherens junction_Homo sapiens_hsa045201.88283097
19Vibrio cholerae infection_Homo sapiens_hsa051101.86318968
20Small cell lung cancer_Homo sapiens_hsa052221.86158559
21Primary immunodeficiency_Homo sapiens_hsa053401.84974352
22Prostate cancer_Homo sapiens_hsa052151.83899256
23Focal adhesion_Homo sapiens_hsa045101.79863953
24Amoebiasis_Homo sapiens_hsa051461.70019232
25Morphine addiction_Homo sapiens_hsa050321.69703423
26Ether lipid metabolism_Homo sapiens_hsa005651.69092503
27Bladder cancer_Homo sapiens_hsa052191.68885823
28Tight junction_Homo sapiens_hsa045301.67397781
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.65177015
30Olfactory transduction_Homo sapiens_hsa047401.65157124
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.62187629
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61182761
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57430919
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55724028
35Graft-versus-host disease_Homo sapiens_hsa053321.51834862
36Taste transduction_Homo sapiens_hsa047421.45682466
37Other glycan degradation_Homo sapiens_hsa005111.42294082
38Selenocompound metabolism_Homo sapiens_hsa004501.40156211
39Protein digestion and absorption_Homo sapiens_hsa049741.40145610
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.37542346
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35442077
42Fatty acid biosynthesis_Homo sapiens_hsa000611.34667275
43Endometrial cancer_Homo sapiens_hsa052131.34667180
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28903918
45Hippo signaling pathway_Homo sapiens_hsa043901.27984332
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.27965815
47Type I diabetes mellitus_Homo sapiens_hsa049401.27505098
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26391071
49Serotonergic synapse_Homo sapiens_hsa047261.26312046
50Glutamatergic synapse_Homo sapiens_hsa047241.22673627
51Hepatitis C_Homo sapiens_hsa051601.21921249
52Circadian entrainment_Homo sapiens_hsa047131.18526875
53Arginine biosynthesis_Homo sapiens_hsa002201.18013966
54Allograft rejection_Homo sapiens_hsa053301.17217788
55Dorso-ventral axis formation_Homo sapiens_hsa043201.16553731
56GABAergic synapse_Homo sapiens_hsa047271.16493274
57Proteoglycans in cancer_Homo sapiens_hsa052051.16426483
58Thyroid hormone synthesis_Homo sapiens_hsa049181.16243264
59Autoimmune thyroid disease_Homo sapiens_hsa053201.14822869
60Homologous recombination_Homo sapiens_hsa034401.14275714
61Circadian rhythm_Homo sapiens_hsa047101.14015592
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13433669
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12522154
64Calcium signaling pathway_Homo sapiens_hsa040201.11833943
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10792636
66Insulin secretion_Homo sapiens_hsa049111.10588161
67Retinol metabolism_Homo sapiens_hsa008301.06716255
68Ovarian steroidogenesis_Homo sapiens_hsa049131.06403515
69Chemical carcinogenesis_Homo sapiens_hsa052041.06397009
70TGF-beta signaling pathway_Homo sapiens_hsa043501.05625331
71Melanoma_Homo sapiens_hsa052181.04303174
72Propanoate metabolism_Homo sapiens_hsa006401.04211528
73Pancreatic cancer_Homo sapiens_hsa052121.03066266
74Toxoplasmosis_Homo sapiens_hsa051451.01901288
75Arachidonic acid metabolism_Homo sapiens_hsa005900.99533701
76Insulin resistance_Homo sapiens_hsa049310.98893693
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98240450
78Regulation of autophagy_Homo sapiens_hsa041400.97945380
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94055713
80Salivary secretion_Homo sapiens_hsa049700.93916969
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91344386
82Glycerolipid metabolism_Homo sapiens_hsa005610.91093406
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88705700
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87222508
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87100449
86Antigen processing and presentation_Homo sapiens_hsa046120.86727619
87Pathways in cancer_Homo sapiens_hsa052000.85813822
88Chronic myeloid leukemia_Homo sapiens_hsa052200.84931024
89Prolactin signaling pathway_Homo sapiens_hsa049170.83884941
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83106060
91Cholinergic synapse_Homo sapiens_hsa047250.82426963
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81184044
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80590317
94Asthma_Homo sapiens_hsa053100.79665416
95Type II diabetes mellitus_Homo sapiens_hsa049300.78802443
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78180161
97Long-term depression_Homo sapiens_hsa047300.77112252
98T cell receptor signaling pathway_Homo sapiens_hsa046600.76527950
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.75873569
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75416871
101Peroxisome_Homo sapiens_hsa041460.73014857
102Fatty acid degradation_Homo sapiens_hsa000710.71760614
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.71541312
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.70988324
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.70291092
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68305961
107ErbB signaling pathway_Homo sapiens_hsa040120.68060617
108Sulfur relay system_Homo sapiens_hsa041220.67583143
109Influenza A_Homo sapiens_hsa051640.65842737
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65608391
111Oxytocin signaling pathway_Homo sapiens_hsa049210.64658463
112mTOR signaling pathway_Homo sapiens_hsa041500.64595844
113Cocaine addiction_Homo sapiens_hsa050300.63747148
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63630446
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62860985
116cAMP signaling pathway_Homo sapiens_hsa040240.61879951
117Glioma_Homo sapiens_hsa052140.61211539
118ABC transporters_Homo sapiens_hsa020100.61178410
119MicroRNAs in cancer_Homo sapiens_hsa052060.60874051
120Fanconi anemia pathway_Homo sapiens_hsa034600.60822322
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60631694
122Lysosome_Homo sapiens_hsa041420.60479223
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60156025
124Thyroid cancer_Homo sapiens_hsa052160.59179469
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58338332
126Fructose and mannose metabolism_Homo sapiens_hsa000510.57321067
127Inositol phosphate metabolism_Homo sapiens_hsa005620.57160106
128beta-Alanine metabolism_Homo sapiens_hsa004100.57139980
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56751301
130Renin secretion_Homo sapiens_hsa049240.55531078
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54946035
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54763405
133AMPK signaling pathway_Homo sapiens_hsa041520.54582774
134Dopaminergic synapse_Homo sapiens_hsa047280.53806643
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53714245
136Non-small cell lung cancer_Homo sapiens_hsa052230.53390724
137Rheumatoid arthritis_Homo sapiens_hsa053230.53356881
138Collecting duct acid secretion_Homo sapiens_hsa049660.53066563
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52398804
140Basal cell carcinoma_Homo sapiens_hsa052170.51974427
141Lysine degradation_Homo sapiens_hsa003100.51312239
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51220833
143Basal transcription factors_Homo sapiens_hsa030220.51018119
144FoxO signaling pathway_Homo sapiens_hsa040680.49141595
145Estrogen signaling pathway_Homo sapiens_hsa049150.48804145
146Gastric acid secretion_Homo sapiens_hsa049710.48789314
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48536850
148Acute myeloid leukemia_Homo sapiens_hsa052210.48456936
149TNF signaling pathway_Homo sapiens_hsa046680.48312380
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47298791
151Wnt signaling pathway_Homo sapiens_hsa043100.47266488
152Platelet activation_Homo sapiens_hsa046110.45598152
153Choline metabolism in cancer_Homo sapiens_hsa052310.45271323
154Arginine and proline metabolism_Homo sapiens_hsa003300.44469992
155Caffeine metabolism_Homo sapiens_hsa002320.43881436
156Hematopoietic cell lineage_Homo sapiens_hsa046400.43661763
157Amphetamine addiction_Homo sapiens_hsa050310.43426758
158Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43334337
159African trypanosomiasis_Homo sapiens_hsa051430.42230080
160HIF-1 signaling pathway_Homo sapiens_hsa040660.41807795
161Ras signaling pathway_Homo sapiens_hsa040140.40294042
162Rap1 signaling pathway_Homo sapiens_hsa040150.39929269
163RNA degradation_Homo sapiens_hsa030180.39578619
164Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39462980
165Vascular smooth muscle contraction_Homo sapiens_hsa042700.39408451
166SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38804110
167PPAR signaling pathway_Homo sapiens_hsa033200.38697798
168NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38552920
169RNA polymerase_Homo sapiens_hsa030200.38508935
170Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38080674
171Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37674897
172Sphingolipid metabolism_Homo sapiens_hsa006000.37488739
173Legionellosis_Homo sapiens_hsa051340.36316015
174Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36120194
175Pyruvate metabolism_Homo sapiens_hsa006200.35018399
176Endocytosis_Homo sapiens_hsa041440.34457700
177Histidine metabolism_Homo sapiens_hsa003400.33823827
178alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33056538
179Hepatitis B_Homo sapiens_hsa051610.31117259
180Insulin signaling pathway_Homo sapiens_hsa049100.29592046
181VEGF signaling pathway_Homo sapiens_hsa043700.29580431

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