TCAF2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.79963189
2positive regulation of chemokine secretion (GO:0090197)5.29932307
3negative regulation of cAMP-mediated signaling (GO:0043951)5.13036149
4negative T cell selection (GO:0043383)4.96256480
5negative thymic T cell selection (GO:0045060)4.91519110
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.88213458
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.85916954
8negative regulation of cell killing (GO:0031342)4.85916954
9positive regulation of macrophage activation (GO:0043032)4.52641662
10regulation of gamma-delta T cell activation (GO:0046643)4.49399049
11regulation of chemokine secretion (GO:0090196)4.49071138
12tolerance induction (GO:0002507)4.38759844
13positive regulation of type 2 immune response (GO:0002830)4.35812824
14regulation of gamma-delta T cell differentiation (GO:0045586)4.24808554
15regulation of immunoglobulin secretion (GO:0051023)4.23716065
16regulation of translation in response to stress (GO:0043555)4.23708613
17regulation of regulatory T cell differentiation (GO:0045589)4.23612580
18histone mRNA catabolic process (GO:0071044)4.08161444
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07639771
20interferon-gamma production (GO:0032609)4.04097043
21interferon-gamma secretion (GO:0072643)4.03538934
22positive regulation of interleukin-4 production (GO:0032753)3.98139206
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.94772297
24positive T cell selection (GO:0043368)3.94147523
25negative regulation of adaptive immune response (GO:0002820)3.92544535
26T cell selection (GO:0045058)3.88280781
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.88006561
28neuron cell-cell adhesion (GO:0007158)3.81158027
29positive regulation of granulocyte differentiation (GO:0030854)3.77576949
30negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.77527861
31regulation of interleukin-13 production (GO:0032656)3.76546925
32response to interleukin-15 (GO:0070672)3.75478132
33antigen processing and presentation of endogenous antigen (GO:0019883)3.71683846
34negative regulation of T cell mediated immunity (GO:0002710)3.64296021
35regulation of B cell receptor signaling pathway (GO:0050855)3.60224207
36thymic T cell selection (GO:0045061)3.58901296
37pyrimidine dimer repair (GO:0006290)3.58891026
38T cell migration (GO:0072678)3.58306142
39cellular response to interleukin-15 (GO:0071350)3.57748029
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.51253685
41negative regulation of production of molecular mediator of immune response (GO:0002701)3.46240524
42regulation of interleukin-4 production (GO:0032673)3.43522280
43toxin transport (GO:1901998)3.42672742
44positive thymic T cell selection (GO:0045059)3.41155668
45regulation of interleukin-5 production (GO:0032674)3.33654897
46mannose metabolic process (GO:0006013)3.33152986
47microtubule nucleation (GO:0007020)3.28321603
48leukocyte aggregation (GO:0070486)3.27879973
49phosphatidylinositol phosphorylation (GO:0046854)3.26526141
50ER overload response (GO:0006983)3.23767652
51positive regulation of alpha-beta T cell proliferation (GO:0046641)3.22990308
52regulation of alpha-beta T cell proliferation (GO:0046640)3.22135156
53positive regulation of B cell differentiation (GO:0045579)3.21445431
54activated T cell proliferation (GO:0050798)3.20713798
55regulation of immunoglobulin production (GO:0002637)3.16146212
56alpha-beta T cell activation (GO:0046631)3.15600896
57regulation of type 2 immune response (GO:0002828)3.13960995
58positive regulation of DNA recombination (GO:0045911)3.13576133
59regulation of T cell tolerance induction (GO:0002664)3.12776163
60neutrophil activation involved in immune response (GO:0002283)3.11844972
61alpha-beta T cell differentiation (GO:0046632)3.11463628
62regulation of isotype switching (GO:0045191)3.08640083
63lipid phosphorylation (GO:0046834)3.05202703
64response to muramyl dipeptide (GO:0032495)3.04926004
65positive regulation of immunoglobulin production (GO:0002639)2.97943546
66regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.96429791
67regulation of natural killer cell mediated immunity (GO:0002715)2.96429791
68CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.96250905
69T cell differentiation involved in immune response (GO:0002292)2.94480510
70alpha-beta T cell differentiation involved in immune response (GO:0002293)2.94480510
71alpha-beta T cell activation involved in immune response (GO:0002287)2.94480510
72positive regulation of tolerance induction (GO:0002645)2.93911002
73regulation of T-helper 1 type immune response (GO:0002825)2.93858106
74negative regulation of lymphocyte mediated immunity (GO:0002707)2.93674562
75CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.93260643
76T-helper cell differentiation (GO:0042093)2.93260643
77cellular response to arsenic-containing substance (GO:0071243)2.91204587
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.88800921
79regulation of interleukin-2 biosynthetic process (GO:0045076)2.88694183
80regulation of isotype switching to IgG isotypes (GO:0048302)2.86649194
81positive regulation of interleukin-2 production (GO:0032743)2.86243016
82regulation of B cell differentiation (GO:0045577)2.85229518
83lysosome localization (GO:0032418)2.84470189
84negative regulation of interleukin-12 production (GO:0032695)2.83969083
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.80770936
86negative regulation of glycoprotein biosynthetic process (GO:0010561)2.79569731
87neutrophil activation (GO:0042119)2.77993396
88cellular response to type I interferon (GO:0071357)2.77987009
89type I interferon signaling pathway (GO:0060337)2.77987009
90response to type I interferon (GO:0034340)2.77690189
91histone lysine demethylation (GO:0070076)2.76626096
92lymph node development (GO:0048535)2.75879558
93positive regulation of natural killer cell mediated immunity (GO:0002717)2.75095341
94regulation of tolerance induction (GO:0002643)2.74127384
95CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.73843061
96regulation of RIG-I signaling pathway (GO:0039535)2.73722683
97hepatocyte apoptotic process (GO:0097284)2.73177936
98NIK/NF-kappaB signaling (GO:0038061)2.72669503
99regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.69915336
100histone H3-K36 demethylation (GO:0070544)2.68893370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.04627818
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.46290407
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.95093567
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.45910527
5RUNX_20019798_ChIP-Seq_JUKART_Human3.42389756
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.38019293
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.16873433
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15498051
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.12659315
10MYB_26560356_Chip-Seq_TH2_Human2.88121965
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.78397071
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76909524
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71932751
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.63383521
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51612122
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.43844215
17MYB_26560356_Chip-Seq_TH1_Human2.41706275
18MAF_26560356_Chip-Seq_TH1_Human2.38105234
19GATA3_27048872_Chip-Seq_THYMUS_Human2.32841451
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.31429782
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21022019
22SPI1_23127762_ChIP-Seq_K562_Human2.18291481
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11996505
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07356604
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06865653
26UTX_26944678_Chip-Seq_JUKART_Human2.04082788
27SCL_19346495_ChIP-Seq_HPC-7_Human1.91252192
28SPI1_23547873_ChIP-Seq_NB4_Human1.82189562
29MAF_26560356_Chip-Seq_TH2_Human1.81843623
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81282724
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79675569
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.76765256
33GATA3_26560356_Chip-Seq_TH2_Human1.76700043
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76205794
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.76019395
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75292477
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71952515
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65010037
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61219569
40MYC_22102868_ChIP-Seq_BL_Human1.59979881
41GATA1_19941826_ChIP-Seq_K562_Human1.58374552
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.51312038
43TCF7_22412390_ChIP-Seq_EML_Mouse1.49747872
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47547330
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40240901
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39527830
47GATA2_19941826_ChIP-Seq_K562_Human1.35966374
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35062943
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.32201977
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31388832
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.29221683
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.28613746
53VDR_24787735_ChIP-Seq_THP-1_Human1.28002684
54VDR_24763502_ChIP-Seq_THP-1_Human1.27793601
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.26994466
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25268084
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24584976
58PU_27001747_Chip-Seq_BMDM_Mouse1.24102904
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22815616
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21574711
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20315657
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17982445
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17312096
64KDM2B_26808549_Chip-Seq_DND41_Human1.15437372
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12878865
66FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12784942
67GATA1_22025678_ChIP-Seq_K562_Human1.11923560
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09291469
69VDR_21846776_ChIP-Seq_THP-1_Human1.05482018
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02193263
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00924836
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99984597
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94021540
74GATA3_26560356_Chip-Seq_TH1_Human0.91140283
75GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90070666
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89943139
77ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88248521
78BP1_19119308_ChIP-ChIP_Hs578T_Human0.82617017
79SMRT_27268052_Chip-Seq_Bcells_Human0.81748140
80ELK3_25401928_ChIP-Seq_HUVEC_Human0.81343539
81IRF1_19129219_ChIP-ChIP_H3396_Human0.81125126
82TFEB_21752829_ChIP-Seq_HELA_Human0.80311348
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79214483
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78916652
85RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78630873
86EGR1_19374776_ChIP-ChIP_THP-1_Human0.78235804
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77444310
88NCOR1_26117541_ChIP-Seq_K562_Human0.77248882
89CIITA_25753668_ChIP-Seq_RAJI_Human0.77154378
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75340542
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.74668531
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.74174341
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73702226
94PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72627965
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71262205
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.70588626
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.70113695
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68810521
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.68035326
100RARB_24833708_ChIP-Seq_LIVER_Mouse0.66738802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.95476256
2MP0005671_abnormal_response_to3.25128562
3MP0003436_decreased_susceptibility_to3.14302954
4MP0003724_increased_susceptibility_to3.07512373
5MP0001835_abnormal_antigen_presentation3.02413280
6MP0002254_reproductive_system_inflammat2.97644507
7MP0005000_abnormal_immune_tolerance2.83190288
8MP0001800_abnormal_humoral_immune2.80504250
9MP0005387_immune_system_phenotype2.57411740
10MP0001790_abnormal_immune_system2.57411740
11MP0002723_abnormal_immune_serum2.53783210
12MP0003300_gastrointestinal_ulcer2.44545240
13MP0002405_respiratory_system_inflammati2.42250042
14MP0002148_abnormal_hypersensitivity_rea2.38499043
15MP0009785_altered_susceptibility_to2.33562822
16MP0002420_abnormal_adaptive_immunity2.29818042
17MP0001819_abnormal_immune_cell2.26547084
18MP0004947_skin_inflammation2.21167381
19MP0005464_abnormal_platelet_physiology2.21029035
20MP0002452_abnormal_antigen_presenting2.19375293
21MP0005025_abnormal_response_to2.17540570
22MP0003303_peritoneal_inflammation2.16095428
23MP0000685_abnormal_immune_system2.16022826
24MP0000703_abnormal_thymus_morphology2.10672628
25MP0010155_abnormal_intestine_physiology2.09038350
26MP0002398_abnormal_bone_marrow2.07827257
27MP0004885_abnormal_endolymph2.01370085
28MP0002009_preneoplasia2.00203746
29MP0002419_abnormal_innate_immunity1.95846939
30MP0000015_abnormal_ear_pigmentation1.90516171
31MP0000716_abnormal_immune_system1.88657676
32MP0009333_abnormal_splenocyte_physiolog1.86711592
33MP0006082_CNS_inflammation1.83533461
34MP0002132_abnormal_respiratory_system1.83042418
35MP0002722_abnormal_immune_system1.76913991
36MP0000689_abnormal_spleen_morphology1.76849402
37MP0009764_decreased_sensitivity_to1.74985958
38MP0001845_abnormal_inflammatory_respons1.69326658
39MP0002166_altered_tumor_susceptibility1.66736367
40MP0000465_gastrointestinal_hemorrhage1.65097572
41MP0001873_stomach_inflammation1.64807581
42MP0004510_myositis1.63322314
43MP0003866_abnormal_defecation1.56808624
44MP0002429_abnormal_blood_cell1.56530246
45MP0008961_abnormal_basal_metabolism1.44714364
46MP0008057_abnormal_DNA_replication1.41664027
47MP0005075_abnormal_melanosome_morpholog1.34554919
48MP0002998_abnormal_bone_remodeling1.33982650
49MP0004883_abnormal_blood_vessel1.32407526
50MP0003091_abnormal_cell_migration1.29641960
51MP0001533_abnormal_skeleton_physiology1.28170572
52MP0001853_heart_inflammation1.21843862
53MP0008260_abnormal_autophagy1.18214843
54MP0003656_abnormal_erythrocyte_physiolo1.16997026
55MP0002933_joint_inflammation1.15249844
56MP0003795_abnormal_bone_structure1.14227590
57MP0004742_abnormal_vestibular_system1.13463072
58MP0000569_abnormal_digit_pigmentation1.13037372
59MP0002163_abnormal_gland_morphology1.12943051
60MP0005310_abnormal_salivary_gland1.11094457
61MP0001851_eye_inflammation1.09951140
62MP0004381_abnormal_hair_follicle1.08311024
63MP0008004_abnormal_stomach_pH1.03359138
64MP0008469_abnormal_protein_level1.02238100
65MP0000858_altered_metastatic_potential1.01939150
66MP0002006_tumorigenesis1.01934717
67MP0009115_abnormal_fat_cell0.99184742
68MP0001986_abnormal_taste_sensitivity0.94992147
69MP0003172_abnormal_lysosome_physiology0.93992440
70MP0008995_early_reproductive_senescence0.93161120
71MP0002138_abnormal_hepatobiliary_system0.91098735
72MP0000249_abnormal_blood_vessel0.90519793
73MP0005451_abnormal_body_composition0.89699779
74MP0009765_abnormal_xenobiotic_induced0.88636558
75MP0006035_abnormal_mitochondrial_morpho0.88475077
76MP0009763_increased_sensitivity_to0.85603076
77MP0005666_abnormal_adipose_tissue0.84724215
78MP0005164_abnormal_response_to0.84502049
79MP0001765_abnormal_ion_homeostasis0.82155309
80MP0002277_abnormal_respiratory_mucosa0.79363573
81MP0010352_gastrointestinal_tract_polyps0.78678542
82MP0001440_abnormal_grooming_behavior0.70462684
83MP0002332_abnormal_exercise_endurance0.70234568
84MP0009278_abnormal_bone_marrow0.69942362
85MP0002970_abnormal_white_adipose0.69856320
86MP0002019_abnormal_tumor_incidence0.69461874
87MP0003828_pulmonary_edema0.68298779
88MP0002693_abnormal_pancreas_physiology0.68297703
89MP0003453_abnormal_keratinocyte_physiol0.67420913
90MP0003075_altered_response_to0.66545349
91MP0005397_hematopoietic_system_phenotyp0.65310628
92MP0001545_abnormal_hematopoietic_system0.65310628
93MP0005375_adipose_tissue_phenotype0.64702784
94MP0004808_abnormal_hematopoietic_stem0.64664126
95MP0003045_fibrosis0.62793166
96MP0003195_calcinosis0.62606759
97MP0003950_abnormal_plasma_membrane0.61573970
98MP0002971_abnormal_brown_adipose0.60455807
99MP0003191_abnormal_cellular_cholesterol0.60426024
100MP0005670_abnormal_white_adipose0.56873074

Predicted human phenotypes

RankGene SetZ-score
1Conjugated hyperbilirubinemia (HP:0002908)5.63930525
2Stomatitis (HP:0010280)4.82401019
3T lymphocytopenia (HP:0005403)4.45615113
4Abnormality of the right ventricle (HP:0001707)4.25556864
5Abnormality of T cell number (HP:0011839)4.25469111
6Elevated erythrocyte sedimentation rate (HP:0003565)4.02502979
7Entropion (HP:0000621)3.90623194
8Spontaneous hematomas (HP:0007420)3.81583891
9Papilloma (HP:0012740)3.79059669
10Verrucae (HP:0200043)3.79059669
11Eczematoid dermatitis (HP:0000976)3.72725512
12Myositis (HP:0100614)3.46826464
13Autoimmune hemolytic anemia (HP:0001890)3.36188475
14Prolonged bleeding time (HP:0003010)3.32609323
15Papilledema (HP:0001085)3.29533942
16Basal cell carcinoma (HP:0002671)3.25991365
17Conjunctival hamartoma (HP:0100780)3.20195039
18Retrobulbar optic neuritis (HP:0100654)3.18758304
19Optic neuritis (HP:0100653)3.18758304
20Thickened calvaria (HP:0002684)3.17866430
21Rectal prolapse (HP:0002035)3.16174076
22Hip dysplasia (HP:0001385)3.11985239
23Hematochezia (HP:0002573)3.03769279
24Cutaneous melanoma (HP:0012056)3.02545083
25Poikiloderma (HP:0001029)3.00667006
26Recurrent bacterial skin infections (HP:0005406)2.96514496
27Recurrent fungal infections (HP:0002841)2.95661473
28Pustule (HP:0200039)2.94101531
29Orchitis (HP:0100796)2.89499908
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.88516546
31Epistaxis (HP:0000421)2.85205711
32Recurrent viral infections (HP:0004429)2.81180948
33Abnormality of T cells (HP:0002843)2.80103197
34Gastrointestinal infarctions (HP:0005244)2.78673806
35Lymphopenia (HP:0001888)2.76674400
36Severe combined immunodeficiency (HP:0004430)2.69678145
37Abnormality of eosinophils (HP:0001879)2.57731211
38Recurrent abscess formation (HP:0002722)2.57390172
39Abnormality of cells of the lymphoid lineage (HP:0012140)2.56942677
40Keratitis (HP:0000491)2.54242507
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.53450617
42Leukocytosis (HP:0001974)2.50878098
43Abnormality of incisor morphology (HP:0011063)2.49240347
44Increased IgM level (HP:0003496)2.45266498
45Vasculitis (HP:0002633)2.41808676
46Keratoconjunctivitis sicca (HP:0001097)2.40305045
47Granulocytopenia (HP:0001913)2.39229841
48Abnormality of macrophages (HP:0004311)2.38789035
49Gingival bleeding (HP:0000225)2.38023459
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.37641795
51Metabolic alkalosis (HP:0200114)2.36412393
52Hemoptysis (HP:0002105)2.34262933
53IgG deficiency (HP:0004315)2.33238340
54Hepatitis (HP:0012115)2.32284772
5511 pairs of ribs (HP:0000878)2.29633398
56Episodic fever (HP:0001954)2.27258356
57Craniofacial hyperostosis (HP:0004493)2.26201905
58Mucosal telangiectasiae (HP:0100579)2.26095853
59Pulmonary infiltrates (HP:0002113)2.24084868
60Eosinophilia (HP:0001880)2.22670402
61Keratoconjunctivitis (HP:0001096)2.18603358
62Mediastinal lymphadenopathy (HP:0100721)2.18126270
63Arterial thrombosis (HP:0004420)2.15814359
64Meningitis (HP:0001287)2.15266600
65Recurrent bronchitis (HP:0002837)2.15185956
66Recurrent skin infections (HP:0001581)2.12850953
67Abnormality of the nasal septum (HP:0000419)2.12650727
68Abnormality of the renal cortex (HP:0011035)2.12605018
69Long clavicles (HP:0000890)2.11678910
70Pulmonary embolism (HP:0002204)2.09491749
71Menorrhagia (HP:0000132)2.08764992
72Chronic diarrhea (HP:0002028)2.08116652
73Gastrointestinal stroma tumor (HP:0100723)2.07666939
74Combined immunodeficiency (HP:0005387)2.07260135
75Hypokalemic alkalosis (HP:0001949)2.06981953
76Delusions (HP:0000746)2.05219114
77Absent frontal sinuses (HP:0002688)2.04257625
78Abnormality of the frontal sinuses (HP:0002687)2.03240336
79Encephalitis (HP:0002383)2.03110472
80Panhypogammaglobulinemia (HP:0003139)2.00956980
81Chest pain (HP:0100749)1.99526758
82Abnormality of the lumbar spine (HP:0100712)1.97403464
83Cranial hyperostosis (HP:0004437)1.97044626
84Teleangiectasia of the skin (HP:0100585)1.94370747
85Bone cyst (HP:0012062)1.93693576
86Hypoplastic iliac wings (HP:0002866)1.92023191
87Hamartoma of the eye (HP:0010568)1.91514477
88Chronic mucocutaneous candidiasis (HP:0002728)1.90832553
89Recurrent cutaneous fungal infections (HP:0011370)1.90832553
90Acute hepatic failure (HP:0006554)1.90406939
91Thyroiditis (HP:0100646)1.90289124
92Chronic obstructive pulmonary disease (HP:0006510)1.88983790
93Obstructive lung disease (HP:0006536)1.88983790
94Conjunctival telangiectasia (HP:0000524)1.87872095
95Increased density of long bones (HP:0006392)1.86968838
96Renal tubular acidosis (HP:0001947)1.86436139
97Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.86170546
98Coxa valga (HP:0002673)1.86016648
99Abnormality of the wing of the ilium (HP:0011867)1.84644534
100Urticaria (HP:0001025)1.84325345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.52637114
2LATS13.35431788
3FGFR33.28142543
4TXK3.22757820
5MAP3K132.73657189
6NLK2.70881473
7SIK32.63562688
8RIPK42.47990766
9NUAK12.37923743
10IKBKE2.27729603
11MAP3K142.11844572
12PRPF4B2.10065878
13MAPK122.08974655
14JAK31.91176152
15TYK21.86829085
16ZAP701.83133637
17ITK1.73459176
18TAOK31.67712649
19BTK1.64091972
20MAP2K31.59220128
21JAK11.46553279
22BLK1.44242193
23BRD41.42125649
24CSK1.37944690
25FES1.37674919
26MARK31.34188305
27MAP2K61.32511796
28SYK1.31550370
29FGFR41.30965115
30IKBKB1.30365123
31CDK31.29461150
32TEC1.25863501
33TBK11.21896329
34CDK121.20304395
35GRK61.18719627
36BMPR21.16375046
37MAP3K31.12174395
38PDK11.07866429
39LCK1.07565050
40JAK21.06175758
41STK41.05044397
42HCK1.02887902
43KSR21.00723435
44SIK21.00558415
45STK101.00450103
46HIPK20.98551602
47SIK10.95811812
48YES10.95705129
49RAF10.95267973
50LYN0.95093319
51IRAK40.94973484
52EPHA30.93869112
53PKN20.93707613
54MAP3K90.93484760
55ADRBK20.92126445
56PIM10.90578061
57MAP3K10.89053774
58MAP3K20.86700205
59CAMKK20.85772840
60TAOK20.82344592
61PIK3CG0.82187812
62AKT30.79848178
63MAP3K60.78776763
64SGK20.77932366
65WNK10.77525378
66PASK0.77505831
67MAP3K70.76491239
68EPHB10.75568714
69PTK2B0.74188051
70MARK20.71523305
71CLK10.70941015
72MELK0.68780653
73NEK60.66233084
74MAP2K20.66165847
75STK380.65901660
76FRK0.65814090
77IRAK10.65783121
78PDPK10.65251152
79MAP3K50.60683389
80RET0.58206087
81SGK30.56964884
82CHUK0.55795292
83MAPK70.54779548
84CSNK1G10.54647210
85IRAK30.54004212
86NEK90.53895270
87KSR10.53542806
88CDK60.53047722
89PRKCQ0.51450083
90CSF1R0.50279920
91TGFBR20.46269204
92MAPK110.45157803
93FGFR20.43108904
94TAOK10.41923936
95TRPM70.41492083
96PDGFRB0.41302571
97PRKD20.40402841
98STK30.40150493
99FGR0.39399290
100CAMKK10.37703014

Predicted pathways (KEGG)

RankGene SetZ-score
1T cell receptor signaling pathway_Homo sapiens_hsa046602.62862412
2Primary immunodeficiency_Homo sapiens_hsa053402.57159011
3Osteoclast differentiation_Homo sapiens_hsa043802.27269850
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.21898145
5Measles_Homo sapiens_hsa051622.21265664
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.17541262
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.09629328
8Phosphatidylinositol signaling system_Homo sapiens_hsa040701.98434177
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98148517
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.92705576
11Allograft rejection_Homo sapiens_hsa053301.84316227
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83031940
13B cell receptor signaling pathway_Homo sapiens_hsa046621.82987095
14Autoimmune thyroid disease_Homo sapiens_hsa053201.81698869
15Graft-versus-host disease_Homo sapiens_hsa053321.79217785
16Acute myeloid leukemia_Homo sapiens_hsa052211.78598102
17Leishmaniasis_Homo sapiens_hsa051401.69683225
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69219223
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68460037
20Hematopoietic cell lineage_Homo sapiens_hsa046401.67470801
21Type I diabetes mellitus_Homo sapiens_hsa049401.67043780
22Inositol phosphate metabolism_Homo sapiens_hsa005621.65542609
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.62763104
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62013476
25TNF signaling pathway_Homo sapiens_hsa046681.58703379
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.56718045
27Influenza A_Homo sapiens_hsa051641.54678209
28Hepatitis B_Homo sapiens_hsa051611.50658593
29Herpes simplex infection_Homo sapiens_hsa051681.45050556
30FoxO signaling pathway_Homo sapiens_hsa040681.43520222
31Non-small cell lung cancer_Homo sapiens_hsa052231.42766665
32Platelet activation_Homo sapiens_hsa046111.40479923
33mTOR signaling pathway_Homo sapiens_hsa041501.35784297
34Chemokine signaling pathway_Homo sapiens_hsa040621.33208167
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32205837
36Tuberculosis_Homo sapiens_hsa051521.30946833
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28065082
38Prolactin signaling pathway_Homo sapiens_hsa049171.22390418
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16753587
40Hepatitis C_Homo sapiens_hsa051601.15158976
41Toxoplasmosis_Homo sapiens_hsa051451.14746691
42Type II diabetes mellitus_Homo sapiens_hsa049301.13306497
43Legionellosis_Homo sapiens_hsa051341.12402475
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10500747
45Pancreatic cancer_Homo sapiens_hsa052121.08299145
46Malaria_Homo sapiens_hsa051441.03815945
47Rheumatoid arthritis_Homo sapiens_hsa053231.03770013
48Chronic myeloid leukemia_Homo sapiens_hsa052201.01546642
49VEGF signaling pathway_Homo sapiens_hsa043701.00843287
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98227625
51Pertussis_Homo sapiens_hsa051330.95923946
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95773931
53Apoptosis_Homo sapiens_hsa042100.95708489
54Viral myocarditis_Homo sapiens_hsa054160.94945695
55Insulin resistance_Homo sapiens_hsa049310.93101690
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.91699004
57Staphylococcus aureus infection_Homo sapiens_hsa051500.90868604
58Asthma_Homo sapiens_hsa053100.89279844
59Shigellosis_Homo sapiens_hsa051310.88997210
60Endometrial cancer_Homo sapiens_hsa052130.85230692
61Renal cell carcinoma_Homo sapiens_hsa052110.84179807
62Prostate cancer_Homo sapiens_hsa052150.74623705
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73140377
64Antigen processing and presentation_Homo sapiens_hsa046120.70073427
65Epstein-Barr virus infection_Homo sapiens_hsa051690.68437157
66Circadian rhythm_Homo sapiens_hsa047100.68236108
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68181020
68Viral carcinogenesis_Homo sapiens_hsa052030.67096143
69Dorso-ventral axis formation_Homo sapiens_hsa043200.66980983
70African trypanosomiasis_Homo sapiens_hsa051430.66073874
71MAPK signaling pathway_Homo sapiens_hsa040100.64131465
72Salmonella infection_Homo sapiens_hsa051320.63760659
73Long-term potentiation_Homo sapiens_hsa047200.62040390
74Colorectal cancer_Homo sapiens_hsa052100.60162985
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.59711276
76ErbB signaling pathway_Homo sapiens_hsa040120.59173308
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58299507
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57347561
79HIF-1 signaling pathway_Homo sapiens_hsa040660.57151779
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.56907971
81HTLV-I infection_Homo sapiens_hsa051660.55882295
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55486902
83Choline metabolism in cancer_Homo sapiens_hsa052310.55088159
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.54758456
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54184834
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.53765615
87Other glycan degradation_Homo sapiens_hsa005110.49447421
88GnRH signaling pathway_Homo sapiens_hsa049120.49325127
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49193075
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48864400
91Glioma_Homo sapiens_hsa052140.45195464
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44901900
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43068732
94Ras signaling pathway_Homo sapiens_hsa040140.40267563
95MicroRNAs in cancer_Homo sapiens_hsa052060.39478479
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.38090153
97Insulin signaling pathway_Homo sapiens_hsa049100.36362537
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35498749
99Phagosome_Homo sapiens_hsa041450.34903499
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31844962

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