TCAM1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This pseudogene is located downstream from the growth hormone locus on chromosome 17. This locus evolved by a series of partial duplications that have disrupted the human gene. A homologous gene in mouse encodes a testis-specific cell adhesion protein that may play a role in germ cell-Sertoli cell interactions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)6.16733459
2piRNA metabolic process (GO:0034587)5.26354309
3DNA methylation involved in gamete generation (GO:0043046)4.92929418
4male meiosis (GO:0007140)4.90089929
5L-fucose catabolic process (GO:0042355)4.10334086
6fucose catabolic process (GO:0019317)4.10334086
7L-fucose metabolic process (GO:0042354)4.10334086
8response to pheromone (GO:0019236)3.99975047
9meiotic chromosome segregation (GO:0045132)3.98579036
10chromosome organization involved in meiosis (GO:0070192)3.94619510
11respiratory chain complex IV assembly (GO:0008535)3.84488880
12behavioral response to nicotine (GO:0035095)3.73626734
13DNA double-strand break processing (GO:0000729)3.72367838
14regulation of meiosis I (GO:0060631)3.71581508
15regulation of nuclear cell cycle DNA replication (GO:0033262)3.60799628
16resolution of meiotic recombination intermediates (GO:0000712)3.59499255
17replication fork processing (GO:0031297)3.55934783
18detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.53969754
19proteasome assembly (GO:0043248)3.40841984
20ketone body metabolic process (GO:1902224)3.39413086
21male meiosis I (GO:0007141)3.39065010
22protein complex biogenesis (GO:0070271)3.30060288
23cytochrome complex assembly (GO:0017004)3.29062846
24reciprocal meiotic recombination (GO:0007131)3.24628271
25reciprocal DNA recombination (GO:0035825)3.24628271
26negative regulation of DNA-dependent DNA replication (GO:2000104)3.24324951
27NADH dehydrogenase complex assembly (GO:0010257)3.23415192
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23415192
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.23415192
30DNA deamination (GO:0045006)3.21921224
31cellular ketone body metabolic process (GO:0046950)3.18841290
32mitochondrial respiratory chain complex assembly (GO:0033108)3.10099779
33protein-cofactor linkage (GO:0018065)3.09474318
34epithelial cilium movement (GO:0003351)3.08748780
35indolalkylamine metabolic process (GO:0006586)3.07224150
36protein polyglutamylation (GO:0018095)3.04800572
37recombinational repair (GO:0000725)3.04187659
38double-strand break repair via homologous recombination (GO:0000724)3.03773761
39maturation of 5.8S rRNA (GO:0000460)3.03743518
40detection of light stimulus involved in sensory perception (GO:0050962)3.02016209
41detection of light stimulus involved in visual perception (GO:0050908)3.02016209
42meiotic nuclear division (GO:0007126)2.98191256
43pseudouridine synthesis (GO:0001522)2.96337084
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.96263275
45protein K6-linked ubiquitination (GO:0085020)2.95143805
46centriole replication (GO:0007099)2.92432402
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91255692
48mannosylation (GO:0097502)2.89235554
49auditory receptor cell stereocilium organization (GO:0060088)2.86733584
50meiosis I (GO:0007127)2.82950847
51platelet dense granule organization (GO:0060155)2.82182258
52histone H2A acetylation (GO:0043968)2.81614712
53retinal cone cell development (GO:0046549)2.81253141
54neural tube formation (GO:0001841)2.77082816
55mitochondrial RNA metabolic process (GO:0000959)2.74487100
56methionine biosynthetic process (GO:0009086)2.74096288
57maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.72564871
58synaptonemal complex organization (GO:0070193)2.66868207
59indolalkylamine catabolic process (GO:0046218)2.66657784
60tryptophan catabolic process (GO:0006569)2.66657784
61indole-containing compound catabolic process (GO:0042436)2.66657784
62multicellular organism reproduction (GO:0032504)2.66197183
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65237096
64spermatid development (GO:0007286)2.64935822
65preassembly of GPI anchor in ER membrane (GO:0016254)2.64768510
66cilium or flagellum-dependent cell motility (GO:0001539)2.64681343
67DNA catabolic process, exonucleolytic (GO:0000738)2.64139290
68sperm motility (GO:0030317)2.63409093
69water-soluble vitamin biosynthetic process (GO:0042364)2.62924413
70axoneme assembly (GO:0035082)2.61770649
71gene silencing by RNA (GO:0031047)2.61679583
72synaptonemal complex assembly (GO:0007130)2.61565321
73meiotic cell cycle process (GO:1903046)2.60851214
74negative regulation of telomere maintenance (GO:0032205)2.60582727
75peptidyl-histidine modification (GO:0018202)2.59944871
76protein K11-linked deubiquitination (GO:0035871)2.59324045
77regulation of DNA endoreduplication (GO:0032875)2.57156049
78regulation of mitotic spindle checkpoint (GO:1903504)2.56913476
79regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.56913476
80reflex (GO:0060004)2.54728374
81organic cation transport (GO:0015695)2.53984210
82somatic diversification of immune receptors via somatic mutation (GO:0002566)2.52907210
83somatic hypermutation of immunoglobulin genes (GO:0016446)2.52907210
84behavioral response to ethanol (GO:0048149)2.51952006
85acrosome reaction (GO:0007340)2.51863948
86cornea development in camera-type eye (GO:0061303)2.51794904
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51550628
88regulation of cilium movement (GO:0003352)2.50972380
89sperm-egg recognition (GO:0035036)2.50793413
90tryptophan metabolic process (GO:0006568)2.48408902
91tRNA modification (GO:0006400)2.47962962
92detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.47502927
93protein localization to cilium (GO:0061512)2.47433166
94tRNA processing (GO:0008033)2.46137273
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46132712
96ubiquinone biosynthetic process (GO:0006744)2.43855664
97inner ear receptor stereocilium organization (GO:0060122)2.43366504
98photoreceptor cell maintenance (GO:0045494)2.43145147
99cullin deneddylation (GO:0010388)2.39986090
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.39274818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.71265603
2VDR_22108803_ChIP-Seq_LS180_Human3.45751020
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.97957978
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94539905
5IGF1R_20145208_ChIP-Seq_DFB_Human2.89024734
6GBX2_23144817_ChIP-Seq_PC3_Human2.64085211
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55086798
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51631090
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.46011535
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41510355
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.36156751
12FUS_26573619_Chip-Seq_HEK293_Human2.34100900
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31056115
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.30453049
15EWS_26573619_Chip-Seq_HEK293_Human2.30442620
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23558529
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23445023
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98984490
19ER_23166858_ChIP-Seq_MCF-7_Human1.97346901
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.93927512
21P300_19829295_ChIP-Seq_ESCs_Human1.86028643
22ELK1_19687146_ChIP-ChIP_HELA_Human1.81894874
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71016842
24MYC_18940864_ChIP-ChIP_HL60_Human1.68581488
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.64597416
26VDR_23849224_ChIP-Seq_CD4+_Human1.62673696
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61805348
28TAF15_26573619_Chip-Seq_HEK293_Human1.56721144
29* TP53_22573176_ChIP-Seq_HFKS_Human1.56234341
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52735191
31CBP_20019798_ChIP-Seq_JUKART_Human1.52735191
32EZH2_22144423_ChIP-Seq_EOC_Human1.52409252
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50882828
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50851050
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.50018037
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49168469
37IRF1_19129219_ChIP-ChIP_H3396_Human1.47318032
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.47132633
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44342377
40E2F7_22180533_ChIP-Seq_HELA_Human1.39051775
41KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38104934
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.36653382
43STAT3_23295773_ChIP-Seq_U87_Human1.36431065
44NANOG_19829295_ChIP-Seq_ESCs_Human1.35999520
45SOX2_19829295_ChIP-Seq_ESCs_Human1.35999520
46BCAT_22108803_ChIP-Seq_LS180_Human1.32662403
47SMAD4_21799915_ChIP-Seq_A2780_Human1.31991339
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31926780
49TCF4_23295773_ChIP-Seq_U87_Human1.31396178
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31388730
51FOXP3_21729870_ChIP-Seq_TREG_Human1.31379794
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30238158
53NCOR_22424771_ChIP-Seq_293T_Human1.26864888
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26401476
55* FOXA1_25329375_ChIP-Seq_VCAP_Human1.26339471
56* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26339471
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23523650
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23482272
59AR_25329375_ChIP-Seq_VCAP_Human1.19653569
60HOXB7_26014856_ChIP-Seq_BT474_Human1.19200167
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18041830
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17922953
63* GATA3_21878914_ChIP-Seq_MCF-7_Human1.17258916
64ETV1_20927104_ChIP-Seq_GIST48_Human1.14990239
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14631100
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14631100
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14486792
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13799720
69TCF4_22108803_ChIP-Seq_LS180_Human1.13493512
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.13278807
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12868604
72RUNX2_22187159_ChIP-Seq_PCA_Human1.12523180
73* AR_20517297_ChIP-Seq_VCAP_Human1.11818868
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10947108
75PHF8_20622853_ChIP-Seq_HELA_Human1.10606417
76RBPJ_21746931_ChIP-Seq_IB4_Human1.10109951
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08684565
78RNF2_27304074_Chip-Seq_NSC_Mouse1.08330220
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06067587
80PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05254560
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05126358
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.04802999
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04504212
84* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04493786
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04455410
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04043897
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02646441
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02505106
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.01532209
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.01285834
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01217073
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.00397366
93CBX2_22325352_ChIP-Seq_293T-Rex_Human0.99800351
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99584607
95CBX2_27304074_Chip-Seq_ESCs_Mouse0.98380093
96NANOG_18555785_Chip-Seq_ESCs_Mouse0.98235268
97NFYB_21822215_ChIP-Seq_K562_Human0.97644220
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96662833
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96575950
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95421690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.84851173
2MP0002102_abnormal_ear_morphology3.17056244
3MP0008995_early_reproductive_senescence3.12333070
4MP0000372_irregular_coat_pigmentation2.87480311
5MP0008058_abnormal_DNA_repair2.58259676
6MP0003195_calcinosis2.43236450
7MP0005551_abnormal_eye_electrophysiolog2.26485667
8MP0004147_increased_porphyrin_level2.18813363
9MP0000569_abnormal_digit_pigmentation2.07469740
10MP0005410_abnormal_fertilization1.96741702
11MP0009046_muscle_twitch1.94269281
12MP0003136_yellow_coat_color1.91315606
13MP0005174_abnormal_tail_pigmentation1.85188612
14MP0001968_abnormal_touch/_nociception1.81689759
15MP0003646_muscle_fatigue1.79364683
16MP0010094_abnormal_chromosome_stability1.77519860
17MP0001929_abnormal_gametogenesis1.76371444
18MP0006072_abnormal_retinal_apoptosis1.76171942
19MP0005646_abnormal_pituitary_gland1.75171024
20MP0003718_maternal_effect1.72552147
21MP0004885_abnormal_endolymph1.72038724
22MP0002938_white_spotting1.71432779
23MP0002160_abnormal_reproductive_system1.70853907
24MP0008872_abnormal_physiological_respon1.70133260
25MP0003698_abnormal_male_reproductive1.68999595
26MP0001529_abnormal_vocalization1.68748387
27MP0002210_abnormal_sex_determination1.66679101
28MP0005253_abnormal_eye_physiology1.66239987
29MP0005075_abnormal_melanosome_morpholog1.65021450
30MP0004742_abnormal_vestibular_system1.60208867
31MP0002736_abnormal_nociception_after1.59946873
32MP0006276_abnormal_autonomic_nervous1.58458890
33MP0000631_abnormal_neuroendocrine_gland1.55803411
34MP0002876_abnormal_thyroid_physiology1.54264058
35MP0003786_premature_aging1.52551124
36MP0003880_abnormal_central_pattern1.52238148
37MP0002163_abnormal_gland_morphology1.51809738
38MP0009697_abnormal_copulation1.51233058
39MP0002638_abnormal_pupillary_reflex1.48338708
40MP0006036_abnormal_mitochondrial_physio1.48287031
41MP0004133_heterotaxia1.46662921
42MP0003787_abnormal_imprinting1.43798179
43MP0009745_abnormal_behavioral_response1.42863579
44MP0001984_abnormal_olfaction1.41388618
45MP0002837_dystrophic_cardiac_calcinosis1.40932711
46MP0001501_abnormal_sleep_pattern1.40879826
47MP0001986_abnormal_taste_sensitivity1.37862649
48MP0008057_abnormal_DNA_replication1.34784694
49MP0005389_reproductive_system_phenotype1.33869255
50MP0000653_abnormal_sex_gland1.32970145
51MP0005645_abnormal_hypothalamus_physiol1.32913547
52MP0001145_abnormal_male_reproductive1.32581921
53MP0000427_abnormal_hair_cycle1.31888596
54MP0000015_abnormal_ear_pigmentation1.31019677
55MP0008875_abnormal_xenobiotic_pharmacok1.29280630
56MP0005171_absent_coat_pigmentation1.28955403
57MP0002095_abnormal_skin_pigmentation1.26545858
58MP0002272_abnormal_nervous_system1.19848308
59MP0003693_abnormal_embryo_hatching1.19793206
60MP0006292_abnormal_olfactory_placode1.19589316
61MP0001486_abnormal_startle_reflex1.18274958
62MP0005379_endocrine/exocrine_gland_phen1.18180870
63MP0006035_abnormal_mitochondrial_morpho1.17316794
64MP0001485_abnormal_pinna_reflex1.14010418
65MP0002735_abnormal_chemical_nociception1.11620646
66MP0004924_abnormal_behavior1.10121890
67MP0005386_behavior/neurological_phenoty1.10121890
68MP0003806_abnormal_nucleotide_metabolis1.05306003
69MP0008775_abnormal_heart_ventricle1.03578807
70MP0002928_abnormal_bile_duct1.03070661
71MP0001764_abnormal_homeostasis1.00498474
72MP0002557_abnormal_social/conspecific_i0.99453952
73MP0003950_abnormal_plasma_membrane0.99031142
74MP0002572_abnormal_emotion/affect_behav0.98204352
75MP0003121_genomic_imprinting0.97850867
76MP0002138_abnormal_hepatobiliary_system0.96610604
77MP0001919_abnormal_reproductive_system0.94881248
78MP0005647_abnormal_sex_gland0.91911214
79MP0004142_abnormal_muscle_tone0.91032390
80MP0004215_abnormal_myocardial_fiber0.90472950
81MP0002064_seizures0.86530011
82MP0005187_abnormal_penis_morphology0.86372724
83MP0001905_abnormal_dopamine_level0.81639178
84MP0003943_abnormal_hepatobiliary_system0.81201573
85MP0002234_abnormal_pharynx_morphology0.80514100
86MP0001324_abnormal_eye_pigmentation0.80508770
87MP0004043_abnormal_pH_regulation0.80313176
88MP0002229_neurodegeneration0.80276445
89MP0002161_abnormal_fertility/fecundity0.79944017
90MP0001119_abnormal_female_reproductive0.79161934
91MP0003890_abnormal_embryonic-extraembry0.79009270
92MP0000383_abnormal_hair_follicle0.78876690
93MP0000647_abnormal_sebaceous_gland0.77799677
94MP0003567_abnormal_fetal_cardiomyocyte0.77764400
95MP0004145_abnormal_muscle_electrophysio0.76862305
96MP0004085_abnormal_heartbeat0.76560770
97MP0001963_abnormal_hearing_physiology0.75726296
98MP0002067_abnormal_sensory_capabilities0.75597897
99MP0001970_abnormal_pain_threshold0.74736821
100MP0003111_abnormal_nucleus_morphology0.73685199

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.11419005
2Congenital stationary night blindness (HP:0007642)3.71782342
3Pancreatic fibrosis (HP:0100732)3.60110027
4Abnormality of midbrain morphology (HP:0002418)3.56720312
5Molar tooth sign on MRI (HP:0002419)3.56720312
6True hermaphroditism (HP:0010459)3.34477659
7Type II lissencephaly (HP:0007260)3.29227630
8Nephronophthisis (HP:0000090)3.25395427
9Abnormality of the renal cortex (HP:0011035)3.15877000
10Abnormality of the renal medulla (HP:0100957)3.02588754
11Acute necrotizing encephalopathy (HP:0006965)2.90207867
12Aplasia/Hypoplasia of the uvula (HP:0010293)2.84343919
13Acute encephalopathy (HP:0006846)2.71584065
14Chromosomal breakage induced by crosslinking agents (HP:0003221)2.71104015
15Attenuation of retinal blood vessels (HP:0007843)2.68891067
16Increased CSF lactate (HP:0002490)2.67354978
17Chromsome breakage (HP:0040012)2.65200227
18Progressive macrocephaly (HP:0004481)2.64682569
19Cystic liver disease (HP:0006706)2.64326803
20Abnormal biliary tract physiology (HP:0012439)2.57039423
21Bile duct proliferation (HP:0001408)2.57039423
22Abnormality of the ileum (HP:0001549)2.54675440
23Mitochondrial inheritance (HP:0001427)2.52008928
24Meckel diverticulum (HP:0002245)2.51978354
25Abnormal mitochondria in muscle tissue (HP:0008316)2.47378644
26Abnormal rod and cone electroretinograms (HP:0008323)2.47019322
27Tubular atrophy (HP:0000092)2.45793129
28Volvulus (HP:0002580)2.40966763
29Cerebellar dysplasia (HP:0007033)2.40852811
30Abnormality of chromosome stability (HP:0003220)2.35358275
31Gaze-evoked nystagmus (HP:0000640)2.32867013
32Abnormality of the preputium (HP:0100587)2.32805986
33Medial flaring of the eyebrow (HP:0010747)2.32287453
34Hyperventilation (HP:0002883)2.28209738
35Retinal dysplasia (HP:0007973)2.25078617
36Hepatocellular necrosis (HP:0001404)2.24714051
37Progressive inability to walk (HP:0002505)2.23993717
38Sclerocornea (HP:0000647)2.23332361
39Inability to walk (HP:0002540)2.22892141
40Polydipsia (HP:0001959)2.21959592
41Abnormal drinking behavior (HP:0030082)2.21959592
42Hypothermia (HP:0002045)2.21202908
43Aplasia/Hypoplasia of the fovea (HP:0008060)2.19937397
44Hypoplasia of the fovea (HP:0007750)2.19937397
45Hepatic necrosis (HP:0002605)2.19123502
46Neoplasm of the adrenal cortex (HP:0100641)2.18638223
47Abolished electroretinogram (ERG) (HP:0000550)2.17458673
48Pendular nystagmus (HP:0012043)2.16945960
49Lissencephaly (HP:0001339)2.15433060
50Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12671518
51Abnormality of macular pigmentation (HP:0008002)2.11032937
52Aplasia/Hypoplasia of the tongue (HP:0010295)2.09702734
53Chronic hepatic failure (HP:0100626)2.09319194
54Duplicated collecting system (HP:0000081)2.09038286
55Abnormality of the renal collecting system (HP:0004742)2.06226184
56Male pseudohermaphroditism (HP:0000037)2.04251971
57Renal cortical cysts (HP:0000803)2.03433983
58Sloping forehead (HP:0000340)2.03176712
59Duodenal stenosis (HP:0100867)2.02331951
60Small intestinal stenosis (HP:0012848)2.02331951
61Lipid accumulation in hepatocytes (HP:0006561)2.02169348
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.01368703
63Absent/shortened dynein arms (HP:0200106)2.01368703
64Furrowed tongue (HP:0000221)2.00174578
65Abnormality of the fovea (HP:0000493)1.96799469
66Abnormality of alanine metabolism (HP:0010916)1.96143645
67Hyperalaninemia (HP:0003348)1.96143645
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96143645
69Optic disc pallor (HP:0000543)1.95004637
70Small hand (HP:0200055)1.94938963
71Anencephaly (HP:0002323)1.94526069
72Bony spicule pigmentary retinopathy (HP:0007737)1.94194742
73Clubbing of toes (HP:0100760)1.94150854
74Intestinal atresia (HP:0011100)1.93649449
75Increased serum lactate (HP:0002151)1.92564134
76Ketosis (HP:0001946)1.90932307
77Congenital hepatic fibrosis (HP:0002612)1.90703728
78Astigmatism (HP:0000483)1.90270507
79Ketoacidosis (HP:0001993)1.90193558
80Abnormality of the pons (HP:0007361)1.88653265
81Occipital encephalocele (HP:0002085)1.87705326
82Polyuria (HP:0000103)1.87612545
83Nephrogenic diabetes insipidus (HP:0009806)1.86897762
84Abnormality of the labia minora (HP:0012880)1.86027217
85Absent thumb (HP:0009777)1.85696923
86Aplasia/hypoplasia of the uterus (HP:0008684)1.83607550
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82142408
88Abnormal protein N-linked glycosylation (HP:0012347)1.82142408
89Abnormal protein glycosylation (HP:0012346)1.82142408
90Abnormal glycosylation (HP:0012345)1.82142408
91Abnormality of the duodenum (HP:0002246)1.79394480
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.79005303
93Methylmalonic aciduria (HP:0012120)1.78416743
94Oligohydramnios (HP:0001562)1.78187171
95Severe muscular hypotonia (HP:0006829)1.78085441
96Methylmalonic acidemia (HP:0002912)1.77966060
97Febrile seizures (HP:0002373)1.77378797
98Decreased central vision (HP:0007663)1.77328430
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.77174396
100Hypoplasia of the pons (HP:0012110)1.76808188

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.13316443
2PINK13.50140095
3MAP4K23.46683219
4ZAK3.06317196
5NUAK12.82050432
6ADRBK22.40116957
7BMPR1B2.31314514
8INSRR2.01866241
9MAPK132.01713916
10WNK32.00048770
11GRK11.92146793
12TRIM281.89680124
13WNK41.80266739
14MST41.72166068
15MAP3K41.71409022
16TLK11.64398525
17EIF2AK31.62621504
18PLK41.61988965
19EIF2AK11.59604708
20OXSR11.55004884
21PNCK1.54941488
22WEE11.53883990
23MKNK21.50512347
24STK391.48908715
25BCR1.33082998
26MAPKAPK31.27054960
27ACVR1B1.23317579
28MARK31.21951424
29NTRK31.19557163
30PLK31.19517766
31TTK1.17843681
32CCNB11.17118451
33PLK21.16838906
34VRK11.16013242
35BRSK21.10233466
36STK38L1.09806410
37CSNK1G11.06727451
38VRK21.04057858
39TNIK1.01258787
40CSNK1G30.96553454
41CSNK1G20.96416615
42ATR0.94934853
43CASK0.93035737
44MAP2K70.92649484
45DAPK20.92457260
46PLK10.89924861
47PAK30.85668855
48SRPK10.85253283
49LATS10.84231093
50ADRBK10.83438200
51CDC70.81118622
52NME10.80366133
53STK30.79800868
54DYRK20.77263104
55PRKCE0.77182126
56MAP2K60.76711833
57ERBB30.76205286
58MKNK10.76128826
59TAOK30.75828609
60PRKCG0.73695513
61ATM0.73384235
62PTK2B0.71706472
63PRKCI0.69561682
64FGFR20.68973045
65CSNK1A1L0.68351904
66MAPKAPK50.67527606
67EIF2AK20.66241223
68CHEK20.66020251
69RPS6KA50.64040654
70TEC0.64019667
71MINK10.63568390
72MARK10.60991625
73CDK30.58343782
74BUB10.57871680
75NEK20.56860626
76MUSK0.55108315
77TAF10.53320508
78STK160.51366301
79SIK30.49455828
80CLK10.48776671
81PHKG10.48489465
82PHKG20.48489465
83BCKDK0.46441537
84EPHA40.45437168
85CSNK1A10.44449390
86TIE10.42913883
87FER0.41250711
88CAMKK20.37515264
89TGFBR10.36859697
90RPS6KB10.35876408
91PRKAA10.35492748
92CSNK2A10.34872058
93NEK10.33860989
94PRKCQ0.33513327
95CAMK2A0.31402427
96PRKACA0.31182406
97DAPK10.30565855
98KSR10.30014518
99DYRK30.29859340
100FLT30.28864708

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.97197417
2Phototransduction_Homo sapiens_hsa047442.56646447
3Fanconi anemia pathway_Homo sapiens_hsa034602.56297161
4Basal transcription factors_Homo sapiens_hsa030222.48562298
5One carbon pool by folate_Homo sapiens_hsa006702.44291973
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.40115546
7Butanoate metabolism_Homo sapiens_hsa006502.35538732
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29500974
9Oxidative phosphorylation_Homo sapiens_hsa001902.24713156
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20773348
11RNA polymerase_Homo sapiens_hsa030202.17180297
12Protein export_Homo sapiens_hsa030602.10925573
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04373471
14Linoleic acid metabolism_Homo sapiens_hsa005912.04013657
15Selenocompound metabolism_Homo sapiens_hsa004502.03706844
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99313176
17Nitrogen metabolism_Homo sapiens_hsa009101.96009651
18Non-homologous end-joining_Homo sapiens_hsa034501.94571764
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91795067
20Proteasome_Homo sapiens_hsa030501.85107350
21Parkinsons disease_Homo sapiens_hsa050121.83816112
22RNA degradation_Homo sapiens_hsa030181.80079938
23Propanoate metabolism_Homo sapiens_hsa006401.77799518
24Olfactory transduction_Homo sapiens_hsa047401.72466639
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.72062691
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62962722
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55126485
28Nicotine addiction_Homo sapiens_hsa050331.48910108
29Mismatch repair_Homo sapiens_hsa034301.46693213
30Ether lipid metabolism_Homo sapiens_hsa005651.43928522
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42878289
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36125721
33RNA transport_Homo sapiens_hsa030131.35391541
34Huntingtons disease_Homo sapiens_hsa050161.34149472
35Tryptophan metabolism_Homo sapiens_hsa003801.32627350
36Base excision repair_Homo sapiens_hsa034101.18430098
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18349612
38DNA replication_Homo sapiens_hsa030301.18099504
39Taste transduction_Homo sapiens_hsa047421.17921503
40Caffeine metabolism_Homo sapiens_hsa002321.17594563
41Nucleotide excision repair_Homo sapiens_hsa034201.16690127
42Purine metabolism_Homo sapiens_hsa002301.15090659
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.13642768
44Pyrimidine metabolism_Homo sapiens_hsa002401.06140789
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.97440026
46Alzheimers disease_Homo sapiens_hsa050100.95894492
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.93319402
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90215729
49Collecting duct acid secretion_Homo sapiens_hsa049660.87072987
50Regulation of autophagy_Homo sapiens_hsa041400.84163068
51Metabolic pathways_Homo sapiens_hsa011000.81955317
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80401975
53Chemical carcinogenesis_Homo sapiens_hsa052040.78771389
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78543035
55Retinol metabolism_Homo sapiens_hsa008300.77568701
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.77373982
57Cardiac muscle contraction_Homo sapiens_hsa042600.77207789
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75306265
59Morphine addiction_Homo sapiens_hsa050320.75018809
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74840477
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73403255
62Peroxisome_Homo sapiens_hsa041460.71010725
63ABC transporters_Homo sapiens_hsa020100.70916015
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70583668
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69826634
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69817070
67Spliceosome_Homo sapiens_hsa030400.69119737
68Arachidonic acid metabolism_Homo sapiens_hsa005900.67613027
69Pyruvate metabolism_Homo sapiens_hsa006200.66755804
70GABAergic synapse_Homo sapiens_hsa047270.64026514
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63910815
72beta-Alanine metabolism_Homo sapiens_hsa004100.63821511
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60029525
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59969103
75mRNA surveillance pathway_Homo sapiens_hsa030150.59129557
76Oocyte meiosis_Homo sapiens_hsa041140.58976799
77Serotonergic synapse_Homo sapiens_hsa047260.57370314
78Glycerolipid metabolism_Homo sapiens_hsa005610.55859484
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55527484
80Fatty acid elongation_Homo sapiens_hsa000620.55328773
81Fatty acid metabolism_Homo sapiens_hsa012120.54768627
82Cell cycle_Homo sapiens_hsa041100.54565098
83Circadian entrainment_Homo sapiens_hsa047130.53431894
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53428171
85Insulin secretion_Homo sapiens_hsa049110.51921541
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49086299
87Glutamatergic synapse_Homo sapiens_hsa047240.48438806
88Fat digestion and absorption_Homo sapiens_hsa049750.46153397
89Ovarian steroidogenesis_Homo sapiens_hsa049130.46119081
90Glutathione metabolism_Homo sapiens_hsa004800.45546069
91Dorso-ventral axis formation_Homo sapiens_hsa043200.45405899
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44804042
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.43420738
94Circadian rhythm_Homo sapiens_hsa047100.42094565
95Salivary secretion_Homo sapiens_hsa049700.41702941
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39434112
97Calcium signaling pathway_Homo sapiens_hsa040200.36599405
98Sulfur metabolism_Homo sapiens_hsa009200.35146681
99Lysine degradation_Homo sapiens_hsa003100.34031644
100Steroid biosynthesis_Homo sapiens_hsa001000.33660628

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »