TCEA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)5.03353175
2mitotic metaphase plate congression (GO:0007080)4.92180440
3protein localization to kinetochore (GO:0034501)4.78050237
4nuclear pore organization (GO:0006999)4.66973490
5nuclear pore complex assembly (GO:0051292)4.43632183
6DNA unwinding involved in DNA replication (GO:0006268)4.32918838
7mitotic nuclear envelope disassembly (GO:0007077)4.32513638
8L-serine metabolic process (GO:0006563)4.30582597
9DNA topological change (GO:0006265)4.29432503
10regulation of spindle organization (GO:0090224)4.27513864
11metaphase plate congression (GO:0051310)4.25532441
12DNA strand elongation involved in DNA replication (GO:0006271)4.21238503
13folic acid-containing compound biosynthetic process (GO:0009396)4.20070519
14DNA replication initiation (GO:0006270)4.18433571
15purine nucleobase biosynthetic process (GO:0009113)4.16884060
16regulation of translational fidelity (GO:0006450)4.16208259
17nucleobase biosynthetic process (GO:0046112)4.15941392
18protein localization to chromosome, centromeric region (GO:0071459)4.11834594
19membrane disassembly (GO:0030397)4.02859447
20nuclear envelope disassembly (GO:0051081)4.02859447
21DNA strand elongation (GO:0022616)3.99134247
22DNA replication checkpoint (GO:0000076)3.98128023
23establishment of chromosome localization (GO:0051303)3.89490594
24chromatin remodeling at centromere (GO:0031055)3.89412371
25CENP-A containing nucleosome assembly (GO:0034080)3.88605913
26telomere maintenance via semi-conservative replication (GO:0032201)3.88019133
27regulation of mitotic spindle organization (GO:0060236)3.87373154
28attachment of spindle microtubules to kinetochore (GO:0008608)3.86726109
29formation of translation preinitiation complex (GO:0001731)3.83931536
30ribosome assembly (GO:0042255)3.82505432
31establishment of viral latency (GO:0019043)3.82225745
32DNA replication-dependent nucleosome assembly (GO:0006335)3.82146317
33DNA replication-dependent nucleosome organization (GO:0034723)3.82146317
34mitotic chromosome condensation (GO:0007076)3.80464630
35IMP biosynthetic process (GO:0006188)3.74475048
36telomere maintenance via recombination (GO:0000722)3.70495464
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.69166992
38mitotic recombination (GO:0006312)3.68616434
39positive regulation of chromosome segregation (GO:0051984)3.67819804
40tRNA aminoacylation for protein translation (GO:0006418)3.67328687
41DNA replication-independent nucleosome organization (GO:0034724)3.65231792
42DNA replication-independent nucleosome assembly (GO:0006336)3.65231792
43double-strand break repair via nonhomologous end joining (GO:0006303)3.65140481
44non-recombinational repair (GO:0000726)3.65140481
45kinetochore organization (GO:0051383)3.64194127
46tRNA aminoacylation (GO:0043039)3.59804548
47amino acid activation (GO:0043038)3.59804548
48DNA ligation (GO:0006266)3.57630608
49regulation of helicase activity (GO:0051095)3.52045334
50mitotic sister chromatid segregation (GO:0000070)3.48042402
51COPI coating of Golgi vesicle (GO:0048205)3.47479164
52Golgi transport vesicle coating (GO:0048200)3.47479164
53ribosome biogenesis (GO:0042254)3.46077643
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44694320
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.43192359
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.43192359
57positive regulation of mitotic sister chromatid separation (GO:1901970)3.43192359
58sister chromatid segregation (GO:0000819)3.40893043
59regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.37418205
60spindle checkpoint (GO:0031577)3.36579536
61pore complex assembly (GO:0046931)3.34123733
62IMP metabolic process (GO:0046040)3.33161541
63regulation of chromosome segregation (GO:0051983)3.31754523
64maturation of SSU-rRNA (GO:0030490)3.31110107
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.30131000
66histone exchange (GO:0043486)3.30109872
67mitotic sister chromatid cohesion (GO:0007064)3.29364117
68regulation of centriole replication (GO:0046599)3.28127283
69protein localization to chromosome (GO:0034502)3.27378928
70somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26110292
71somatic hypermutation of immunoglobulin genes (GO:0016446)3.26110292
72protein complex localization (GO:0031503)3.25653081
73regulation of sister chromatid cohesion (GO:0007063)3.25128507
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.24955779
75telomere maintenance via telomere lengthening (GO:0010833)3.24581714
76negative regulation of chromosome segregation (GO:0051985)3.23939952
77regulation of histone H3-K9 methylation (GO:0051570)3.23917834
78spindle assembly checkpoint (GO:0071173)3.22451578
79negative regulation of mitotic sister chromatid separation (GO:2000816)3.22156303
80negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22156303
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22156303
82negative regulation of sister chromatid segregation (GO:0033046)3.22156303
83pre-miRNA processing (GO:0031054)3.19086972
84mitotic spindle assembly checkpoint (GO:0007094)3.18882258
85mitotic spindle checkpoint (GO:0071174)3.17201994
86nucleotide-excision repair, DNA gap filling (GO:0006297)3.17144951
87kinetochore assembly (GO:0051382)3.16585149
88cellular protein complex localization (GO:0034629)3.16156075
89meiotic chromosome segregation (GO:0045132)3.16135475
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.15693509
91serine family amino acid biosynthetic process (GO:0009070)3.12799642
92nuclear envelope organization (GO:0006998)3.10882364
93regulation of centrosome cycle (GO:0046605)3.10017225
94DNA duplex unwinding (GO:0032508)3.09909602
95regulation of mitotic sister chromatid separation (GO:0010965)3.09199992
96regulation of mitotic sister chromatid segregation (GO:0033047)3.09199992
97regulation of sister chromatid segregation (GO:0033045)3.09199992
98DNA geometric change (GO:0032392)3.08290997
99mitochondrial DNA metabolic process (GO:0032042)3.07453298
100regulation of DNA endoreduplication (GO:0032875)3.07184799
101chromatin assembly or disassembly (GO:0006333)3.06970166
102heterochromatin organization (GO:0070828)3.06681098
103mitotic G2/M transition checkpoint (GO:0044818)3.04570645
104regulation of translational termination (GO:0006449)3.03315366
105histone H2A monoubiquitination (GO:0035518)3.02420326
106chromosome segregation (GO:0007059)3.00838396
107postreplication repair (GO:0006301)2.98580590
108regulation of double-strand break repair via homologous recombination (GO:0010569)2.94194218
109DNA conformation change (GO:0071103)2.92799895
110regulation of nuclear cell cycle DNA replication (GO:0033262)2.92203760
111regulation of translational elongation (GO:0006448)2.91401345
112protein K6-linked ubiquitination (GO:0085020)2.91113188
113negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.89667929
114folic acid metabolic process (GO:0046655)2.87600203
115mitotic G2 DNA damage checkpoint (GO:0007095)2.86512996
116mismatch repair (GO:0006298)2.85583549
117regulation of RNA export from nucleus (GO:0046831)2.84237106
118histone-serine phosphorylation (GO:0035404)2.83891282
119RNA-dependent DNA replication (GO:0006278)2.83164898
120ATP-dependent chromatin remodeling (GO:0043044)2.80840064
121telomere maintenance (GO:0000723)2.79992274
122ribonucleoprotein complex biogenesis (GO:0022613)2.79765834
123translesion synthesis (GO:0019985)2.79501107
124telomere organization (GO:0032200)2.78814244
125monoubiquitinated protein deubiquitination (GO:0035520)2.77824907
126dosage compensation (GO:0007549)2.77646199
127mitotic cell cycle (GO:0000278)2.74274213
128ribosomal small subunit assembly (GO:0000028)2.69429960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.99166913
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.49234516
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.91418799
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.83023077
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26382610
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24501395
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.83574624
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78766995
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66800185
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65411375
11AR_21909140_ChIP-Seq_LNCAP_Human2.60667929
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.52220778
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46957701
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.44796355
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39325749
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37255217
17* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32698640
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.30121009
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.17962664
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15823923
21VDR_23849224_ChIP-Seq_CD4+_Human2.14533595
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08689657
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06824268
24XRN2_22483619_ChIP-Seq_HELA_Human2.04770674
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97845030
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95996884
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93477841
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86458637
29FOXP3_21729870_ChIP-Seq_TREG_Human1.82626815
30ELK1_19687146_ChIP-ChIP_HELA_Human1.79482564
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78992111
32DCP1A_22483619_ChIP-Seq_HELA_Human1.75809207
33MYC_22102868_ChIP-Seq_BL_Human1.75558496
34GABP_19822575_ChIP-Seq_HepG2_Human1.71413701
35* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68649071
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68550664
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66756422
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66485914
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63772031
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.60972177
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57874718
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56767493
43* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55487474
44TTF2_22483619_ChIP-Seq_HELA_Human1.55013760
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54633219
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53860287
47KDM5A_27292631_Chip-Seq_BREAST_Human1.51539077
48* RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51354798
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.45949520
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41914336
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41765260
52CIITA_25753668_ChIP-Seq_RAJI_Human1.39783435
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35090981
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34965949
55CLOCK_20551151_ChIP-Seq_293T_Human1.33787629
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33634050
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32330661
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31159770
59TFEB_21752829_ChIP-Seq_HELA_Human1.31026188
60* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28802212
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28692463
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25395067
63SOX17_20123909_ChIP-Seq_XEN_Mouse1.21630788
64* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21446310
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21066563
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.18366454
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18315412
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16929512
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16124929
70* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15385898
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14996500
72* TP63_19390658_ChIP-ChIP_HaCaT_Human1.13621441
73ZNF263_19887448_ChIP-Seq_K562_Human1.13401701
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13218021
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10463527
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10256288
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10037759
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08825515
79* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07484459
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.05912818
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05186214
82* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.05053186
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04754254
84* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04535582
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02797453
86* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02226703
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.01925226
88* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01415533
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99970465
90TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98723963
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97683756
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97629964
93SOX2_16153702_ChIP-ChIP_HESCs_Human0.97386718
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.96919699
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96254246
96SPI1_23547873_ChIP-Seq_NB4_Human0.95601747
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.94727323
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94315630
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92249108
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92157029
101* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89508994
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85819386
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85678857
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84867321
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84446110
106MYC_18940864_ChIP-ChIP_HL60_Human0.84132801
107* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82608034
108CHD1_26751641_Chip-Seq_LNCaP_Human0.82054214
109KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78609140
110KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78609140
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78609140
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77289437
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76276613
114* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75079612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.96392580
2MP0010094_abnormal_chromosome_stability4.34295011
3MP0004957_abnormal_blastocyst_morpholog4.18123087
4MP0003111_abnormal_nucleus_morphology4.15362115
5MP0003077_abnormal_cell_cycle3.88639713
6MP0008057_abnormal_DNA_replication3.87070591
7MP0008007_abnormal_cellular_replicative2.96148180
8MP0008058_abnormal_DNA_repair2.93589576
9MP0002009_preneoplasia2.89181302
10MP0010352_gastrointestinal_tract_polyps2.82409636
11MP0009697_abnormal_copulation2.71906703
12MP0003123_paternal_imprinting2.71439832
13MP0003941_abnormal_skin_development2.67432019
14MP0010307_abnormal_tumor_latency2.51254455
15MP0000350_abnormal_cell_proliferation2.40737902
16MP0002396_abnormal_hematopoietic_system2.30237307
17MP0001730_embryonic_growth_arrest2.30197365
18MP0008932_abnormal_embryonic_tissue2.17071942
19MP0008877_abnormal_DNA_methylation1.97882583
20MP0005380_embryogenesis_phenotype1.75359451
21MP0001672_abnormal_embryogenesis/_devel1.75359451
22* MP0001697_abnormal_embryo_size1.74214425
23MP0000490_abnormal_crypts_of1.66426973
24MP0003718_maternal_effect1.63099461
25MP0003705_abnormal_hypodermis_morpholog1.62145622
26MP0005076_abnormal_cell_differentiation1.61692127
27MP0003984_embryonic_growth_retardation1.58042463
28MP0002088_abnormal_embryonic_growth/wei1.54472420
29* MP0002080_prenatal_lethality1.54220208
30MP0002084_abnormal_developmental_patter1.53378933
31MP0002086_abnormal_extraembryonic_tissu1.52558261
32MP0003656_abnormal_erythrocyte_physiolo1.52169527
33MP0002085_abnormal_embryonic_tissue1.50299213
34MP0002019_abnormal_tumor_incidence1.46776564
35MP0004197_abnormal_fetal_growth/weight/1.45207345
36MP0003786_premature_aging1.39884514
37MP0000313_abnormal_cell_death1.38734535
38* MP0004808_abnormal_hematopoietic_stem1.37062752
39MP0002877_abnormal_melanocyte_morpholog1.36851058
40MP0003806_abnormal_nucleotide_metabolis1.36429884
41MP0005501_abnormal_skin_physiology1.33224930
42MP0006054_spinal_hemorrhage1.32751577
43MP0003121_genomic_imprinting1.32476961
44MP0003567_abnormal_fetal_cardiomyocyte1.31896618
45MP0009333_abnormal_splenocyte_physiolog1.27630130
46MP0001661_extended_life_span1.24890961
47MP0002697_abnormal_eye_size1.23096744
48MP0005397_hematopoietic_system_phenotyp1.21926326
49MP0001545_abnormal_hematopoietic_system1.21926326
50MP0002796_impaired_skin_barrier1.20951842
51MP0001293_anophthalmia1.17707612
52MP0002398_abnormal_bone_marrow1.17332042
53MP0003890_abnormal_embryonic-extraembry1.16258703
54MP0004185_abnormal_adipocyte_glucose1.11736151
55MP0003763_abnormal_thymus_physiology1.09780451
56MP0010234_abnormal_vibrissa_follicle1.09721562
57MP0004233_abnormal_muscle_weight1.06881813
58MP0001188_hyperpigmentation1.06559443
59MP0004147_increased_porphyrin_level1.05457755
60MP0010030_abnormal_orbit_morphology1.03892350
61MP0000703_abnormal_thymus_morphology1.02323172
62MP0002722_abnormal_immune_system1.00575236
63MP0000689_abnormal_spleen_morphology1.00546769
64MP0002006_tumorigenesis1.00084342
65MP0003186_abnormal_redox_activity0.98056080
66MP0005023_abnormal_wound_healing0.97853387
67MP0001915_intracranial_hemorrhage0.97077088
68MP0000858_altered_metastatic_potential0.95746624
69MP0004264_abnormal_extraembryonic_tissu0.95470598
70MP0005621_abnormal_cell_physiology0.94202889
71MP0002210_abnormal_sex_determination0.93768292
72MP0006035_abnormal_mitochondrial_morpho0.91335503
73MP0001119_abnormal_female_reproductive0.91258325
74MP0005384_cellular_phenotype0.90917486
75MP0005367_renal/urinary_system_phenotyp0.89565990
76MP0000516_abnormal_urinary_system0.89565990
77MP0010678_abnormal_skin_adnexa0.89459645
78MP0009053_abnormal_anal_canal0.87690124
79MP0009703_decreased_birth_body0.87254847
80* MP0002429_abnormal_blood_cell0.86364688
81MP0001145_abnormal_male_reproductive0.84112747
82MP0002254_reproductive_system_inflammat0.83992528
83MP0009672_abnormal_birth_weight0.83534888
84MP0001835_abnormal_antigen_presentation0.83035151
85MP0001529_abnormal_vocalization0.82299607
86MP0003385_abnormal_body_wall0.81140338
87MP0004782_abnormal_surfactant_physiolog0.80713246
88MP0000358_abnormal_cell_content/0.79973366
89MP0000537_abnormal_urethra_morphology0.79708644
90MP0000716_abnormal_immune_system0.78997865
91MP0004272_abnormal_basement_membrane0.78758148
92MP0002060_abnormal_skin_morphology0.77165275
93MP0000653_abnormal_sex_gland0.76587361
94MP0001299_abnormal_eye_distance/0.76231914
95MP0000685_abnormal_immune_system0.74577356
96MP0000377_abnormal_hair_follicle0.74537489
97MP0002166_altered_tumor_susceptibility0.73712682
98MP0003448_altered_tumor_morphology0.73638863
99MP0001800_abnormal_humoral_immune0.73636279
100MP0002233_abnormal_nose_morphology0.73633022
101MP0003221_abnormal_cardiomyocyte_apopto0.73534949
102MP0002092_abnormal_eye_morphology0.73390729
103MP0000647_abnormal_sebaceous_gland0.72843615
104MP0005220_abnormal_exocrine_pancreas0.72575962
105MP0003566_abnormal_cell_adhesion0.72097299
106MP0000477_abnormal_intestine_morphology0.71526195
107MP0003937_abnormal_limbs/digits/tail_de0.71089903
108MP0001929_abnormal_gametogenesis0.69496854
109MP0003115_abnormal_respiratory_system0.68381708
110MP0001177_atelectasis0.68323536
111MP0001881_abnormal_mammary_gland0.68088776
112MP0000432_abnormal_head_morphology0.67988502
113MP0000733_abnormal_muscle_development0.67523861
114MP0001849_ear_inflammation0.66649740
115MP0002452_abnormal_antigen_presenting0.66553787
116MP0000428_abnormal_craniofacial_morphol0.65755137
117MP0002653_abnormal_ependyma_morphology0.64615385
118MP0005408_hypopigmentation0.64324743
119MP0002420_abnormal_adaptive_immunity0.63306131
120MP0001819_abnormal_immune_cell0.62320509
121MP0005389_reproductive_system_phenotype0.62041188
122MP0003935_abnormal_craniofacial_develop0.61713607
123MP0005671_abnormal_response_to0.61702136
124MP0003861_abnormal_nervous_system0.61532544
125MP0001286_abnormal_eye_development0.61420252
126MP0001853_heart_inflammation0.61280517
127MP0002405_respiratory_system_inflammati0.60031917
128MP0001340_abnormal_eyelid_morphology0.59679690
129MP0000627_abnormal_mammary_gland0.58912537
130* MP0002111_abnormal_tail_morphology0.58407438
131MP0000383_abnormal_hair_follicle0.57949214
132MP0003453_abnormal_keratinocyte_physiol0.57856184
133MP0003315_abnormal_perineum_morphology0.57499934
134MP0003119_abnormal_digestive_system0.56970687
135MP0003943_abnormal_hepatobiliary_system0.55390848

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.98976209
2Colon cancer (HP:0003003)3.85192905
3Nephroblastoma (Wilms tumor) (HP:0002667)3.49133468
4Chromsome breakage (HP:0040012)3.46065102
5Breast hypoplasia (HP:0003187)3.36864116
6Embryonal renal neoplasm (HP:0011794)3.33448716
7Abnormality of the anterior horn cell (HP:0006802)3.31932408
8Degeneration of anterior horn cells (HP:0002398)3.31932408
9Medulloblastoma (HP:0002885)3.23841557
10Agnosia (HP:0010524)3.18551644
11Oral leukoplakia (HP:0002745)3.15017615
12Ependymoma (HP:0002888)3.12710285
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.07779397
14Abnormality of chromosome stability (HP:0003220)3.04698421
15Patellar aplasia (HP:0006443)3.01238141
16Abnormality of the labia minora (HP:0012880)2.99454955
17Selective tooth agenesis (HP:0001592)2.95346627
18Aplasia/Hypoplasia of the patella (HP:0006498)2.90323980
19Rhabdomyosarcoma (HP:0002859)2.78504041
20Microvesicular hepatic steatosis (HP:0001414)2.72517989
21Carpal bone hypoplasia (HP:0001498)2.68558663
22Papillary thyroid carcinoma (HP:0002895)2.66969186
23Overlapping toe (HP:0001845)2.66912668
24Meckel diverticulum (HP:0002245)2.62624768
25Insidious onset (HP:0003587)2.62117732
26Termporal pattern (HP:0011008)2.62117732
27Abnormal lung lobation (HP:0002101)2.61156262
28Myelodysplasia (HP:0002863)2.60715648
29Spastic diplegia (HP:0001264)2.55437125
30Aplastic anemia (HP:0001915)2.53090651
31Abnormality of the preputium (HP:0100587)2.51573332
32Impulsivity (HP:0100710)2.48444004
33Abnormality of the ileum (HP:0001549)2.48244312
34Neoplasm of the pancreas (HP:0002894)2.46066379
35Volvulus (HP:0002580)2.45746956
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.44729279
37Microretrognathia (HP:0000308)2.41434647
38Progressive external ophthalmoplegia (HP:0000590)2.40100879
39Rough bone trabeculation (HP:0100670)2.38618352
40Biliary tract neoplasm (HP:0100574)2.38180560
41Basal cell carcinoma (HP:0002671)2.36600799
42Reticulocytopenia (HP:0001896)2.35559723
43Ankyloglossia (HP:0010296)2.33149357
44Small intestinal stenosis (HP:0012848)2.32685291
45Duodenal stenosis (HP:0100867)2.32685291
46Multiple enchondromatosis (HP:0005701)2.31581214
47Upper limb muscle weakness (HP:0003484)2.30357081
48Proximal placement of thumb (HP:0009623)2.30244046
49Deviation of the thumb (HP:0009603)2.28943797
50Thrombocytosis (HP:0001894)2.26258069
51Embryonal neoplasm (HP:0002898)2.24240052
52Facial hemangioma (HP:0000329)2.22186237
53Amaurosis fugax (HP:0100576)2.21115145
54Pelvic girdle muscle weakness (HP:0003749)2.17612646
55Thyroid carcinoma (HP:0002890)2.17308526
56Neoplasm of the colon (HP:0100273)2.14969037
57Increased nuchal translucency (HP:0010880)2.12663332
58Slender long bone (HP:0003100)2.12118435
59Neoplasm of the oral cavity (HP:0100649)2.11312288
60Uterine neoplasm (HP:0010784)2.10849195
61Atresia of the external auditory canal (HP:0000413)2.10576306
62Short middle phalanx of the 5th finger (HP:0004220)2.10381868
63Pancreatic islet-cell hyperplasia (HP:0004510)2.09961246
64Acute myeloid leukemia (HP:0004808)2.09224437
65Squamous cell carcinoma (HP:0002860)2.09223506
66Sloping forehead (HP:0000340)2.09209454
67Breast carcinoma (HP:0003002)2.09117449
68Cutaneous melanoma (HP:0012056)2.08612230
69Astrocytoma (HP:0009592)2.07871055
70Abnormality of the astrocytes (HP:0100707)2.07871055
71Lymphoma (HP:0002665)2.07145656
72Bone marrow hypocellularity (HP:0005528)2.07013834
73Ectopic kidney (HP:0000086)2.05668794
74Premature graying of hair (HP:0002216)2.05447582
75Uterine leiomyosarcoma (HP:0002891)2.05103130
76Leiomyosarcoma (HP:0100243)2.05103130
77Prominent nose (HP:0000448)2.02759012
78Cafe-au-lait spot (HP:0000957)2.02480011
79Postnatal microcephaly (HP:0005484)2.01656561
80Poor head control (HP:0002421)1.99901805
81Missing ribs (HP:0000921)1.99863845
82Absent radius (HP:0003974)1.99160098
83Glioma (HP:0009733)1.98934715
84Transitional cell carcinoma of the bladder (HP:0006740)1.97593795
85Abnormality of the duodenum (HP:0002246)1.97441679
86Absent thumb (HP:0009777)1.95853990
87Hypoglycemic seizures (HP:0002173)1.95013561
88Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.94705057
89Cortical dysplasia (HP:0002539)1.94176758
90High pitched voice (HP:0001620)1.92953199
91Hypoplasia of the pons (HP:0012110)1.92674694
92Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90748566
93Abnormal biliary tract morphology (HP:0012440)1.90266895
94Abnormality of oral frenula (HP:0000190)1.89602219
95Ankle contracture (HP:0006466)1.87815552
96Malignant gastrointestinal tract tumors (HP:0006749)1.86726011
97Gastrointestinal carcinoma (HP:0002672)1.86726011
98Tracheoesophageal fistula (HP:0002575)1.86631316
9911 pairs of ribs (HP:0000878)1.85738206
100Ovarian neoplasm (HP:0100615)1.85264151
101Cerebral hypomyelination (HP:0006808)1.84422501
102Trismus (HP:0000211)1.84384859
103Abnormality of the carotid arteries (HP:0005344)1.82433120
104Abnormality of chromosome segregation (HP:0002916)1.81920339
105Choanal atresia (HP:0000453)1.81432944
106Abnormality of the calcaneus (HP:0008364)1.81127111
107Absent forearm bone (HP:0003953)1.80945925
108Aplasia involving forearm bones (HP:0009822)1.80945925
109Neoplasm of striated muscle (HP:0009728)1.80471573
110Freckling (HP:0001480)1.80023677
111Bladder carcinoma (HP:0002862)1.79427279
112Bladder neoplasm (HP:0009725)1.79427279
113Neoplasm of the rectum (HP:0100743)1.79170427
114Shoulder girdle muscle weakness (HP:0003547)1.79143615
115Abnormality of methionine metabolism (HP:0010901)1.78252087
116Abnormal trabecular bone morphology (HP:0100671)1.77054159
117Cellular immunodeficiency (HP:0005374)1.75849179
118Stenosis of the external auditory canal (HP:0000402)1.75665493
119Blepharitis (HP:0000498)1.74850258
120Abnormality of the pancreatic islet cells (HP:0006476)1.74337669
121Abnormality of endocrine pancreas physiology (HP:0012093)1.74337669
122Glossoptosis (HP:0000162)1.72789584
123Atrophy/Degeneration involving motor neurons (HP:0007373)1.72510491
124Abnormality of reticulocytes (HP:0004312)1.72153495
125Abnormality of the pons (HP:0007361)1.71917655
126Large hands (HP:0001176)1.71792816
127Insomnia (HP:0100785)1.70972564
128Neoplasm of the small intestine (HP:0100833)1.70316750
129Abnormality of cells of the erythroid lineage (HP:0012130)1.68925989
130Abnormality of glycolysis (HP:0004366)1.67760637
131Spinal muscular atrophy (HP:0007269)1.67678259
132Microglossia (HP:0000171)1.67574954
133Horseshoe kidney (HP:0000085)1.67465786
134Entropion (HP:0000621)1.67118320
135Short 4th metacarpal (HP:0010044)1.66946680
136Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66946680
137Deep philtrum (HP:0002002)1.65866093
138Premature ovarian failure (HP:0008209)1.65792624
139Abnormality of the umbilical cord (HP:0010881)1.64306964
140Reticulocytosis (HP:0001923)1.63918492
141Median cleft lip (HP:0000161)1.63451848
142Gonadotropin excess (HP:0000837)1.61948505
143Neuroblastoma (HP:0003006)1.61371514
144Primitive neuroectodermal tumor (HP:0030065)1.61371514
145Neuroblastic tumors (HP:0004376)1.61371514
146Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.61371514
147Triphalangeal thumb (HP:0001199)1.60833579
148Central scotoma (HP:0000603)1.60531409
149Orthostatic hypotension (HP:0001278)1.59865661
150Acanthocytosis (HP:0001927)1.59466444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.14560199
2WEE13.88364833
3BUB13.42096871
4EIF2AK13.06848240
5NEK23.05558344
6ACVR1B2.69838412
7BRSK22.67244356
8SRPK12.53012301
9TTK2.39846950
10NEK12.39269904
11TSSK62.12836424
12MST42.11998541
13RPS6KA42.04867132
14SCYL22.01949666
15PLK32.00859396
16PLK11.99576720
17BCR1.97013223
18TRIM281.95158249
19EIF2AK31.92771160
20PLK41.88132825
21MKNK11.74187843
22PASK1.73929179
23CDK121.70406523
24AURKB1.68986405
25TAF11.66551364
26EEF2K1.64736813
27ATR1.58942471
28DYRK31.51916712
29RPS6KB21.49009818
30FLT31.46364251
31CDK41.44213248
32BRSK11.38789126
33CHEK21.38365479
34MAP3K81.38076559
35VRK11.36681273
36PKN21.36567067
37STK101.36018993
38LATS11.35906637
39TGFBR11.35324477
40CDK71.32184455
41STK31.29989414
42CHEK11.27047718
43TESK21.27018334
44NME21.22565020
45MKNK21.20255978
46STK41.14145028
47CDK61.09328264
48ZAK1.08648112
49CLK11.06011673
50FRK1.05135622
51VRK21.02071093
52NEK91.01931092
53STK160.99269671
54EPHA20.97293052
55ATM0.94201739
56STK240.89875869
57PAK40.88955627
58PIM10.88943544
59MELK0.87820768
60CCNB10.87312870
61STK38L0.87266569
62ALK0.87247091
63AURKA0.86343144
64CDK20.83956232
65MAP3K100.82522676
66LRRK20.81356122
67MET0.79014549
68PDGFRA0.76735035
69JAK30.76724104
70TLK10.76659334
71SMG10.71670404
72CDK190.70663126
73BMX0.67888799
74KSR10.67223455
75MST1R0.65864540
76NLK0.64683236
77PBK0.64441668
78CDK30.64140128
79SIK30.63842849
80BRAF0.63599055
81PNCK0.60021476
82CDK10.58383146
83TYK20.55366378
84EIF2AK20.55314476
85LATS20.55028395
86CDK80.54589014
87CSNK2A20.52685803
88CSNK2A10.52311944
89CSNK1G10.52247544
90PAK20.49787626
91TESK10.47506366
92PLK20.47083918
93KSR20.45195149
94MAP4K10.44718171
95MAP3K50.44087583
96AKT30.44019660
97PRKCI0.43065486
98CDK140.42944886
99CDK180.42806214
100FGFR10.42746340
101CHUK0.41600503
102MAPKAPK30.39649559
103MAP3K120.39168939
104TEC0.38898250
105MAP2K30.37950571
106ERBB40.36593298
107BRD40.36294989
108CDK11A0.36109619
109MAP3K40.36088367
110ICK0.35740697
111PAK10.35443618
112ERBB30.34300297
113CDK150.34235769
114KIT0.34180474
115IKBKB0.33644361
116NUAK10.32553991
117MARK30.32364358
118ZAP700.32106352
119RAF10.32089652
120RPS6KA50.31740729
121CSF1R0.30989530
122CDK90.30934371
123TAOK20.30579580
124CSNK1A1L0.30409343
125MTOR0.28616942
126PRKDC0.27661853
127PIM20.26940997
128YES10.24826800
129* MAPK140.23791868
130CSNK1E0.23657552
131BTK0.23514951

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.60387566
2Mismatch repair_Homo sapiens_hsa034304.10867510
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.62733512
4RNA transport_Homo sapiens_hsa030133.27486366
5Cell cycle_Homo sapiens_hsa041103.16437732
6Base excision repair_Homo sapiens_hsa034103.02480843
7Spliceosome_Homo sapiens_hsa030402.96132896
8Nucleotide excision repair_Homo sapiens_hsa034202.79054211
9RNA polymerase_Homo sapiens_hsa030202.73370632
10One carbon pool by folate_Homo sapiens_hsa006702.65072688
11Homologous recombination_Homo sapiens_hsa034402.63254820
12Proteasome_Homo sapiens_hsa030502.49120615
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44156691
14Pyrimidine metabolism_Homo sapiens_hsa002402.11667675
15RNA degradation_Homo sapiens_hsa030182.01363650
16Fanconi anemia pathway_Homo sapiens_hsa034601.98924104
17p53 signaling pathway_Homo sapiens_hsa041151.97955971
18Non-homologous end-joining_Homo sapiens_hsa034501.91981259
19Ribosome_Homo sapiens_hsa030101.85883467
20Basal transcription factors_Homo sapiens_hsa030221.84440830
21mRNA surveillance pathway_Homo sapiens_hsa030151.71228207
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48292053
23Vitamin B6 metabolism_Homo sapiens_hsa007501.42407801
24Antigen processing and presentation_Homo sapiens_hsa046121.32353012
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30407615
26Herpes simplex infection_Homo sapiens_hsa051681.30025691
27Epstein-Barr virus infection_Homo sapiens_hsa051691.29941765
28Viral carcinogenesis_Homo sapiens_hsa052031.25935705
29Systemic lupus erythematosus_Homo sapiens_hsa053221.21661547
30Pyruvate metabolism_Homo sapiens_hsa006201.18846801
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15865468
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12739464
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08949869
34Legionellosis_Homo sapiens_hsa051341.04985771
35Purine metabolism_Homo sapiens_hsa002301.04554363
36Oocyte meiosis_Homo sapiens_hsa041141.03612677
37Selenocompound metabolism_Homo sapiens_hsa004501.02369910
38Propanoate metabolism_Homo sapiens_hsa006400.98795037
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.95518218
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92422166
41Folate biosynthesis_Homo sapiens_hsa007900.91718657
42Steroid biosynthesis_Homo sapiens_hsa001000.88491658
43HTLV-I infection_Homo sapiens_hsa051660.88357477
44MicroRNAs in cancer_Homo sapiens_hsa052060.87168459
45Biosynthesis of amino acids_Homo sapiens_hsa012300.85645349
46Small cell lung cancer_Homo sapiens_hsa052220.85399797
47Thyroid cancer_Homo sapiens_hsa052160.83677346
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.81328032
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.80197406
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77884837
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76209535
52Fatty acid elongation_Homo sapiens_hsa000620.76053136
53Primary immunodeficiency_Homo sapiens_hsa053400.73916846
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73580104
55Pentose phosphate pathway_Homo sapiens_hsa000300.72786314
56Measles_Homo sapiens_hsa051620.71871888
57Hepatitis B_Homo sapiens_hsa051610.64114831
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63549028
59Colorectal cancer_Homo sapiens_hsa052100.63412259
60Apoptosis_Homo sapiens_hsa042100.63241082
61Protein export_Homo sapiens_hsa030600.62360023
62TGF-beta signaling pathway_Homo sapiens_hsa043500.62050037
63Influenza A_Homo sapiens_hsa051640.59787082
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55090441
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54320805
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53966369
67Chronic myeloid leukemia_Homo sapiens_hsa052200.53468084
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52423421
69Shigellosis_Homo sapiens_hsa051310.51194599
70mTOR signaling pathway_Homo sapiens_hsa041500.50584092
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.46645045
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.46374501
73Pancreatic cancer_Homo sapiens_hsa052120.46300166
74Hippo signaling pathway_Homo sapiens_hsa043900.46248167
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46117987
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43742607
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43245252
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42933038
79Adherens junction_Homo sapiens_hsa045200.42296885
80Melanoma_Homo sapiens_hsa052180.41459417
81Sulfur relay system_Homo sapiens_hsa041220.40039068
82Wnt signaling pathway_Homo sapiens_hsa043100.39847259
83Lysine degradation_Homo sapiens_hsa003100.39378566
84Leishmaniasis_Homo sapiens_hsa051400.37490271
85Bladder cancer_Homo sapiens_hsa052190.37386911
86Renal cell carcinoma_Homo sapiens_hsa052110.37167942
87Alcoholism_Homo sapiens_hsa050340.36997586
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36786246
89Galactose metabolism_Homo sapiens_hsa000520.35789846
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35538952
91Hematopoietic cell lineage_Homo sapiens_hsa046400.35057950
92N-Glycan biosynthesis_Homo sapiens_hsa005100.35041590
93Prostate cancer_Homo sapiens_hsa052150.34575565
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33134329
95FoxO signaling pathway_Homo sapiens_hsa040680.32867736
96Carbon metabolism_Homo sapiens_hsa012000.32171031
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.31683780
98Arginine biosynthesis_Homo sapiens_hsa002200.30852488
99AMPK signaling pathway_Homo sapiens_hsa041520.30278728
100Fatty acid metabolism_Homo sapiens_hsa012120.30014237
101Type I diabetes mellitus_Homo sapiens_hsa049400.29435957
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28614729
103TNF signaling pathway_Homo sapiens_hsa046680.28342989
104Glutathione metabolism_Homo sapiens_hsa004800.27719751
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26163651
106Toxoplasmosis_Homo sapiens_hsa051450.25764164
107Pathways in cancer_Homo sapiens_hsa052000.25118535
108Arginine and proline metabolism_Homo sapiens_hsa003300.24683787
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24649595
110Viral myocarditis_Homo sapiens_hsa054160.24314951
111Inositol phosphate metabolism_Homo sapiens_hsa005620.24314209
112Non-small cell lung cancer_Homo sapiens_hsa052230.24156759
113Insulin signaling pathway_Homo sapiens_hsa049100.24057189
114HIF-1 signaling pathway_Homo sapiens_hsa040660.24056493
115Tight junction_Homo sapiens_hsa045300.23415866
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.23350027
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23064643
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23039460
119Metabolic pathways_Homo sapiens_hsa011000.22592649
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20510600
121Notch signaling pathway_Homo sapiens_hsa043300.19443375
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18077372
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17792974
124B cell receptor signaling pathway_Homo sapiens_hsa046620.17507089
125Regulation of autophagy_Homo sapiens_hsa041400.16843475
126Endometrial cancer_Homo sapiens_hsa052130.16298187
127Proteoglycans in cancer_Homo sapiens_hsa052050.15973165
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13721488

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