TCEA1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA endoreduplication (GO:0032875)4.46993300
2ribonucleoprotein complex disassembly (GO:0032988)4.42913827
3organelle disassembly (GO:1903008)4.35240133
4protein targeting to Golgi (GO:0000042)4.13157506
5regulation of centriole replication (GO:0046599)4.09636811
6establishment of protein localization to Golgi (GO:0072600)3.99986893
7ribosome assembly (GO:0042255)3.94149712
8establishment of integrated proviral latency (GO:0075713)3.88102973
9retrograde transport, vesicle recycling within Golgi (GO:0000301)3.87135678
10ribosome biogenesis (GO:0042254)3.44606233
11single strand break repair (GO:0000012)3.38540431
12centriole replication (GO:0007099)3.34550893
13proteasome assembly (GO:0043248)3.31280548
14alternative mRNA splicing, via spliceosome (GO:0000380)3.30146718
15ncRNA catabolic process (GO:0034661)3.26764199
16protein complex biogenesis (GO:0070271)3.25433337
17mitochondrial respiratory chain complex assembly (GO:0033108)3.21538716
18positive regulation of histone H3-K4 methylation (GO:0051571)3.19548547
19formation of translation preinitiation complex (GO:0001731)3.14428484
20chaperone-mediated protein transport (GO:0072321)3.09366530
21regulation of histone H3-K9 methylation (GO:0051570)3.06563543
22exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04292655
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.03196261
24DNA ligation (GO:0006266)3.02570239
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01825351
26rRNA catabolic process (GO:0016075)3.01553582
27pyrimidine dimer repair (GO:0006290)2.99308233
28regulation of helicase activity (GO:0051095)2.99022576
29DNA damage response, detection of DNA damage (GO:0042769)2.98967038
30regulation of mitochondrial translation (GO:0070129)2.98774704
31telomere maintenance via telomerase (GO:0007004)2.98312990
32maturation of 5.8S rRNA (GO:0000460)2.96939982
33mitotic sister chromatid cohesion (GO:0007064)2.96676753
34protein localization to Golgi apparatus (GO:0034067)2.95523689
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94377313
36mitochondrial respiratory chain complex I assembly (GO:0032981)2.94377313
37NADH dehydrogenase complex assembly (GO:0010257)2.94377313
38regulation of mitotic spindle checkpoint (GO:1903504)2.93063256
39regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.93063256
40rRNA modification (GO:0000154)2.92922313
41establishment of viral latency (GO:0019043)2.91819162
42ribonucleoprotein complex biogenesis (GO:0022613)2.91601038
43amino acid activation (GO:0043038)2.91198085
44tRNA aminoacylation (GO:0043039)2.91198085
45tRNA aminoacylation for protein translation (GO:0006418)2.88532916
46replication fork processing (GO:0031297)2.87864692
47ribosomal large subunit biogenesis (GO:0042273)2.87351976
48cellular component biogenesis (GO:0044085)2.86884489
49histone exchange (GO:0043486)2.86160425
50histone H2B ubiquitination (GO:0033523)2.85646645
51negative regulation of DNA-dependent DNA replication (GO:2000104)2.84437336
52non-recombinational repair (GO:0000726)2.83210546
53double-strand break repair via nonhomologous end joining (GO:0006303)2.83210546
54rRNA metabolic process (GO:0016072)2.82055235
55CENP-A containing nucleosome assembly (GO:0034080)2.81554114
56rRNA processing (GO:0006364)2.80710295
57regulation of centrosome cycle (GO:0046605)2.80526755
58regulation of telomere maintenance (GO:0032204)2.78323576
59nuclear pore complex assembly (GO:0051292)2.77359715
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77157169
61DNA topological change (GO:0006265)2.77027572
62ER overload response (GO:0006983)2.76233349
63water-soluble vitamin biosynthetic process (GO:0042364)2.74219365
64somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.73071745
65isotype switching (GO:0045190)2.73071745
66somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.73071745
67viral mRNA export from host cell nucleus (GO:0046784)2.70350035
68protein polyglutamylation (GO:0018095)2.69805546
69regulation of centrosome duplication (GO:0010824)2.69398291
70spliceosomal snRNP assembly (GO:0000387)2.68223367
71kinetochore organization (GO:0051383)2.66388606
72chromatin remodeling at centromere (GO:0031055)2.63991116
73histone mRNA metabolic process (GO:0008334)2.62752071
74DNA deamination (GO:0045006)2.62127543
75regulation of RNA export from nucleus (GO:0046831)2.62125604
76somatic recombination of immunoglobulin gene segments (GO:0016447)2.60379132
777-methylguanosine mRNA capping (GO:0006370)2.60058606
78transcription-coupled nucleotide-excision repair (GO:0006283)2.60004213
79rRNA methylation (GO:0031167)2.57115852
80microtubule depolymerization (GO:0007019)2.56559659
81nuclear pore organization (GO:0006999)2.56029722
82anterograde synaptic vesicle transport (GO:0048490)2.56012906
83RNA splicing, via transesterification reactions (GO:0000375)2.55923116
84tRNA metabolic process (GO:0006399)2.55351532
85RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.54420110
86mRNA splicing, via spliceosome (GO:0000398)2.54420110
87RNA capping (GO:0036260)2.52882001
887-methylguanosine RNA capping (GO:0009452)2.52882001
89protein targeting to mitochondrion (GO:0006626)2.52608654
90mitotic metaphase plate congression (GO:0007080)2.51516648
91positive regulation of mRNA processing (GO:0050685)2.49644175
92somatic diversification of immunoglobulins (GO:0016445)2.48888205
93nucleotide-excision repair, DNA gap filling (GO:0006297)2.48751846
94ncRNA metabolic process (GO:0034660)2.46779162
95protein-cofactor linkage (GO:0018065)2.45584621
96anterograde axon cargo transport (GO:0008089)2.44797897
97inner mitochondrial membrane organization (GO:0007007)2.44786928
98somatic hypermutation of immunoglobulin genes (GO:0016446)2.44018238
99somatic diversification of immune receptors via somatic mutation (GO:0002566)2.44018238
100protein K6-linked ubiquitination (GO:0085020)2.43833756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.99318309
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.60555716
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.56867533
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.34056125
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09717051
6E2F7_22180533_ChIP-Seq_HELA_Human2.94694588
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.91490054
8ELK1_19687146_ChIP-ChIP_HELA_Human2.87674383
9VDR_23849224_ChIP-Seq_CD4+_Human2.71332250
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64950733
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62382307
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.60001877
13PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57253103
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38680399
15PADI4_21655091_ChIP-ChIP_MCF-7_Human2.38540946
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33806407
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25110366
18YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21420941
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20098950
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.15271435
21FOXP3_21729870_ChIP-Seq_TREG_Human2.08115362
22IGF1R_20145208_ChIP-Seq_DFB_Human2.07160154
23ZNF274_21170338_ChIP-Seq_K562_Hela2.06078209
24FUS_26573619_Chip-Seq_HEK293_Human2.05704457
25TAF15_26573619_Chip-Seq_HEK293_Human2.03502421
26EWS_26573619_Chip-Seq_HEK293_Human2.03197503
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98040289
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97235670
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93569546
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91832706
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91577596
32MYC_18940864_ChIP-ChIP_HL60_Human1.83502460
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83012837
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75060015
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.74752033
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73582887
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.71220553
38DCP1A_22483619_ChIP-Seq_HELA_Human1.71127896
39IRF1_19129219_ChIP-ChIP_H3396_Human1.68157902
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67577938
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66832507
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65525190
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62498221
44GABP_19822575_ChIP-Seq_HepG2_Human1.58210619
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57489525
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.53009090
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51822155
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50098556
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49680545
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49299970
51CIITA_25753668_ChIP-Seq_RAJI_Human1.48843829
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47946762
53TTF2_22483619_ChIP-Seq_HELA_Human1.45050074
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.44970000
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.44852917
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44768279
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43797296
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39949608
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39679512
60P300_19829295_ChIP-Seq_ESCs_Human1.39460249
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34088875
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.33845594
63GBX2_23144817_ChIP-Seq_PC3_Human1.33277568
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.32639557
65VDR_22108803_ChIP-Seq_LS180_Human1.31809235
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31464614
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30255820
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30144989
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27822371
70XRN2_22483619_ChIP-Seq_HELA_Human1.24819279
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24333131
72CBP_20019798_ChIP-Seq_JUKART_Human1.23831135
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23831135
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22483545
75KDM5A_27292631_Chip-Seq_BREAST_Human1.22299049
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20891404
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19381368
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.18608886
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.18473662
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12783150
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10870244
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08326650
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08035558
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07961093
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07522175
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07124099
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03193800
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02591943
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98804412
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97065992
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95377634
92TFEB_21752829_ChIP-Seq_HELA_Human0.95031279
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94987063
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94511963
95TP53_22573176_ChIP-Seq_HFKS_Human0.92308748
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90859267
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.90525171
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.88788062
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87142181
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86547818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.09915472
2MP0008058_abnormal_DNA_repair3.32982738
3MP0000569_abnormal_digit_pigmentation3.27122106
4MP0008057_abnormal_DNA_replication3.25650069
5MP0003787_abnormal_imprinting3.00271816
6MP0002102_abnormal_ear_morphology2.72723116
7MP0010094_abnormal_chromosome_stability2.67670960
8MP0003111_abnormal_nucleus_morphology2.42265025
9MP0002638_abnormal_pupillary_reflex2.40248945
10MP0003121_genomic_imprinting2.39143238
11MP0006292_abnormal_olfactory_placode2.37558718
12MP0005645_abnormal_hypothalamus_physiol2.28786730
13MP0003693_abnormal_embryo_hatching2.25891198
14MP0006072_abnormal_retinal_apoptosis2.22351169
15MP0004957_abnormal_blastocyst_morpholog2.14819851
16MP0003077_abnormal_cell_cycle2.12945528
17MP0001529_abnormal_vocalization2.11477077
18MP0001984_abnormal_olfaction2.08343374
19MP0004147_increased_porphyrin_level2.06517176
20MP0008007_abnormal_cellular_replicative2.00337005
21MP0003122_maternal_imprinting1.99975795
22MP0009697_abnormal_copulation1.82293948
23MP0002877_abnormal_melanocyte_morpholog1.80233347
24MP0003656_abnormal_erythrocyte_physiolo1.76147416
25MP0009046_muscle_twitch1.68897552
26MP0003786_premature_aging1.54834813
27MP0000778_abnormal_nervous_system1.54662861
28MP0001188_hyperpigmentation1.52307341
29MP0008995_early_reproductive_senescence1.52113873
30MP0002234_abnormal_pharynx_morphology1.51279438
31MP0001293_anophthalmia1.48780086
32MP0006276_abnormal_autonomic_nervous1.44567832
33MP0005253_abnormal_eye_physiology1.40963061
34MP0006035_abnormal_mitochondrial_morpho1.39437848
35MP0008932_abnormal_embryonic_tissue1.37136551
36MP0002736_abnormal_nociception_after1.31392747
37MP0002909_abnormal_adrenal_gland1.30613372
38MP0003186_abnormal_redox_activity1.27818945
39MP0000358_abnormal_cell_content/1.24473158
40MP0003718_maternal_effect1.23065963
41MP0004859_abnormal_synaptic_plasticity1.21157703
42MP0005084_abnormal_gallbladder_morpholo1.20563186
43MP0005377_hearing/vestibular/ear_phenot1.19170304
44MP0003878_abnormal_ear_physiology1.19170304
45MP0006036_abnormal_mitochondrial_physio1.17967937
46MP0002095_abnormal_skin_pigmentation1.14532827
47MP0004142_abnormal_muscle_tone1.14140643
48MP0010307_abnormal_tumor_latency1.12223605
49MP0000631_abnormal_neuroendocrine_gland1.10401685
50MP0001697_abnormal_embryo_size1.05734133
51MP0003880_abnormal_central_pattern1.05628824
52MP0001905_abnormal_dopamine_level1.05406883
53MP0003937_abnormal_limbs/digits/tail_de1.04923392
54MP0002938_white_spotting1.04118133
55MP0002177_abnormal_outer_ear1.03855738
56MP0005174_abnormal_tail_pigmentation1.03173391
57MP0002084_abnormal_developmental_patter1.01330819
58MP0001929_abnormal_gametogenesis1.01227862
59MP0004197_abnormal_fetal_growth/weight/1.00649560
60MP0003890_abnormal_embryonic-extraembry1.00304954
61MP0004811_abnormal_neuron_physiology0.97203979
62MP0005391_vision/eye_phenotype0.96882028
63MP0001727_abnormal_embryo_implantation0.96314958
64MP0002210_abnormal_sex_determination0.94476585
65MP0001542_abnormal_bone_strength0.94340731
66MP0000350_abnormal_cell_proliferation0.94273066
67MP0001968_abnormal_touch/_nociception0.94160143
68MP0003567_abnormal_fetal_cardiomyocyte0.93760936
69MP0001764_abnormal_homeostasis0.93373738
70MP0003221_abnormal_cardiomyocyte_apopto0.91689292
71MP0008872_abnormal_physiological_respon0.86909800
72MP0005499_abnormal_olfactory_system0.85758602
73MP0005394_taste/olfaction_phenotype0.85758602
74MP0002557_abnormal_social/conspecific_i0.85007701
75MP0001730_embryonic_growth_arrest0.84949392
76MP0003698_abnormal_male_reproductive0.84719992
77MP0002928_abnormal_bile_duct0.80909872
78MP0001145_abnormal_male_reproductive0.80312569
79MP0002090_abnormal_vision0.79737457
80MP0001286_abnormal_eye_development0.78451988
81MP0004885_abnormal_endolymph0.78434189
82MP0002653_abnormal_ependyma_morphology0.78131608
83MP0008961_abnormal_basal_metabolism0.77863605
84MP0005551_abnormal_eye_electrophysiolog0.77362299
85MP0000955_abnormal_spinal_cord0.77148994
86MP0000313_abnormal_cell_death0.76960779
87MP0000653_abnormal_sex_gland0.76533704
88MP0005389_reproductive_system_phenotype0.76033229
89MP0001919_abnormal_reproductive_system0.76002802
90MP0001485_abnormal_pinna_reflex0.72148188
91MP0005410_abnormal_fertilization0.70531169
92MP0002067_abnormal_sensory_capabilities0.70484678
93MP0005075_abnormal_melanosome_morpholog0.69786073
94MP0002080_prenatal_lethality0.69071944
95MP0008789_abnormal_olfactory_epithelium0.68439726
96MP0001299_abnormal_eye_distance/0.68130211
97MP0002184_abnormal_innervation0.67606026
98MP0002822_catalepsy0.67157161
99MP0002085_abnormal_embryonic_tissue0.66887747
100MP0003861_abnormal_nervous_system0.66639134

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.41889530
2Abnormal mitochondria in muscle tissue (HP:0008316)4.18162187
3Volvulus (HP:0002580)3.87588968
4Progressive macrocephaly (HP:0004481)3.77413190
5Acute encephalopathy (HP:0006846)3.67242155
6Chronic hepatic failure (HP:0100626)3.57302718
7Mitochondrial inheritance (HP:0001427)3.31574893
8Increased CSF lactate (HP:0002490)3.18393412
9Cerebral edema (HP:0002181)2.92207839
10Methylmalonic acidemia (HP:0002912)2.87327029
11Decreased activity of mitochondrial respiratory chain (HP:0008972)2.86463410
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.86463410
13Increased hepatocellular lipid droplets (HP:0006565)2.81818298
14Multiple enchondromatosis (HP:0005701)2.79806025
15Molar tooth sign on MRI (HP:0002419)2.67205270
16Abnormality of midbrain morphology (HP:0002418)2.67205270
17Lipid accumulation in hepatocytes (HP:0006561)2.63837584
18Drooling (HP:0002307)2.59967396
19Hyperglycinemia (HP:0002154)2.58660239
20Increased intramyocellular lipid droplets (HP:0012240)2.56142444
21Pancreatic cysts (HP:0001737)2.53210389
22Pancreatic fibrosis (HP:0100732)2.51934352
23Leukodystrophy (HP:0002415)2.50090541
24Nephronophthisis (HP:0000090)2.47323194
25Medial flaring of the eyebrow (HP:0010747)2.34023871
26Abnormality of alanine metabolism (HP:0010916)2.28449790
27Hyperalaninemia (HP:0003348)2.28449790
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28449790
29Excessive salivation (HP:0003781)2.28145691
30Increased serum lactate (HP:0002151)2.26267177
31Abnormality of the labia minora (HP:0012880)2.24499652
32Renal Fanconi syndrome (HP:0001994)2.24074497
33Lactic acidosis (HP:0003128)2.16680705
34Abnormality of cells of the erythroid lineage (HP:0012130)2.16257603
35Small hand (HP:0200055)2.16222402
36Abnormality of renal resorption (HP:0011038)2.15161391
37Hepatocellular necrosis (HP:0001404)2.14532917
38Abnormal number of erythroid precursors (HP:0012131)2.06829756
39Failure to thrive in infancy (HP:0001531)2.05947870
40Hepatic necrosis (HP:0002605)2.05417954
41Exercise intolerance (HP:0003546)2.03112991
42Abnormality of the renal medulla (HP:0100957)2.02699669
43Prominent metopic ridge (HP:0005487)2.00104756
44Respiratory failure (HP:0002878)1.99534058
45Methylmalonic aciduria (HP:0012120)1.98913995
46Tubulointerstitial nephritis (HP:0001970)1.98151129
47Abnormal number of incisors (HP:0011064)1.95735630
48Rib fusion (HP:0000902)1.95083023
49Type I transferrin isoform profile (HP:0003642)1.94862470
50Abnormality of the metopic suture (HP:0005556)1.93458404
51Abnormality of serum amino acid levels (HP:0003112)1.92244898
52Increased muscle lipid content (HP:0009058)1.91856111
53True hermaphroditism (HP:0010459)1.91180681
54Abnormal protein glycosylation (HP:0012346)1.90978599
55Abnormal glycosylation (HP:0012345)1.90978599
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90978599
57Abnormal protein N-linked glycosylation (HP:0012347)1.90978599
58Papillary thyroid carcinoma (HP:0002895)1.90298969
59Cortical dysplasia (HP:0002539)1.86107112
60Optic disc pallor (HP:0000543)1.86051765
61Abnormality of the anterior horn cell (HP:0006802)1.84492548
62Degeneration of anterior horn cells (HP:0002398)1.84492548
63Abnormality of chromosome stability (HP:0003220)1.84136999
64Abnormal hair whorl (HP:0010721)1.81120491
653-Methylglutaconic aciduria (HP:0003535)1.78511848
66Thyroid-stimulating hormone excess (HP:0002925)1.76517390
67Aplastic anemia (HP:0001915)1.76333182
68Hypothermia (HP:0002045)1.74686305
69Hypoplasia of the pons (HP:0012110)1.71766827
70Chromsome breakage (HP:0040012)1.71375126
71Congenital primary aphakia (HP:0007707)1.70685446
72Abnormality of the pons (HP:0007361)1.69711435
73Short tibia (HP:0005736)1.69050549
74Aplasia/Hypoplasia of the tibia (HP:0005772)1.67889051
75Neonatal respiratory distress (HP:0002643)1.67406057
76Postnatal microcephaly (HP:0005484)1.67160624
77Tubular atrophy (HP:0000092)1.67100148
78IgM deficiency (HP:0002850)1.66203076
79Colon cancer (HP:0003003)1.63977297
80Hypsarrhythmia (HP:0002521)1.62742820
81Meckel diverticulum (HP:0002245)1.61008876
82Aplasia/hypoplasia of the uterus (HP:0008684)1.60636679
83Lethargy (HP:0001254)1.60124287
84Medulloblastoma (HP:0002885)1.59886562
85Abnormality of the antihelix (HP:0009738)1.59791817
86Abnormality of the renal cortex (HP:0011035)1.59705911
87X-linked dominant inheritance (HP:0001423)1.59704735
88Thyroid carcinoma (HP:0002890)1.59550623
89Gait imbalance (HP:0002141)1.59458414
90Abnormality of the ileum (HP:0001549)1.59264608
91Narrow forehead (HP:0000341)1.59096288
92Lissencephaly (HP:0001339)1.58707582
93Broad foot (HP:0001769)1.56977994
94Poor suck (HP:0002033)1.56735577
95EEG with generalized epileptiform discharges (HP:0011198)1.55657128
96Horseshoe kidney (HP:0000085)1.54689515
97Submucous cleft hard palate (HP:0000176)1.54625841
98Glioma (HP:0009733)1.54505133
99Epileptiform EEG discharges (HP:0011182)1.53589694
100Hyperinsulinemic hypoglycemia (HP:0000825)1.53446485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.37340856
2MST43.15004564
3ZAK2.62929869
4SRPK12.56353303
5TNIK2.54860021
6VRK12.45920800
7MAP3K42.33754972
8PLK22.29970340
9NUAK12.27146177
10TRIM282.14248006
11CASK2.13311969
12MKNK22.05917048
13MAP4K22.04184394
14PLK41.94285740
15TSSK61.93063929
16PLK31.88365350
17CDK121.88141196
18BRD41.84975191
19MAP2K71.84427576
20PNCK1.77668912
21BMPR1B1.72656149
22MKNK11.65655333
23BCR1.64440310
24SCYL21.57855493
25TLK11.51509705
26EIF2AK11.47154338
27VRK21.46641622
28CSNK1G21.39921041
29RPS6KA41.34346403
30NEK11.33274541
31EIF2AK31.30817452
32PLK11.25486336
33WNK31.22956968
34STK161.20876349
35CDK191.17468543
36TIE11.15560420
37FRK1.15538986
38TTK1.12459387
39WNK41.10595078
40STK38L1.10301496
41RPS6KA51.06736593
42STK391.05649707
43ATM1.04629085
44CHEK11.04138564
45ATR1.02514286
46CSNK1G10.99515939
47AURKA0.96088439
48CSNK1G30.95728872
49DYRK20.91193026
50TAOK30.89046285
51AURKB0.87412445
52DYRK30.86863693
53CSNK1E0.86321217
54CHEK20.83480482
55BCKDK0.82196519
56GRK10.81415047
57CSNK1A1L0.78613823
58NEK20.74102560
59ALK0.69727120
60CSNK2A20.68989525
61CAMK1G0.66282850
62MARK10.63588223
63WNK10.62672158
64CDK90.62338579
65ADRBK20.60130163
66CDK20.59187851
67KDR0.57193115
68CDK10.57112989
69AKT30.56932826
70PAK30.56245774
71CDK30.54148225
72CSNK2A10.53893675
73TAF10.52012629
74RPS6KB20.51107693
75PRKDC0.50993377
76BRSK20.50513980
77CLK10.50498386
78PINK10.49465359
79WEE10.48717896
80DMPK0.48023769
81CSNK1D0.47015908
82PRKACB0.46434394
83OXSR10.44797354
84PDK20.43680497
85MAPK140.43205315
86TEC0.41026061
87DYRK1A0.39516479
88STK40.38132292
89GSK3B0.38085264
90STK30.37994983
91PRKCG0.37813764
92LATS10.37004969
93CDK70.36630361
94PRKCE0.36115545
95PBK0.35164311
96EIF2AK20.34917782
97PHKG20.34338730
98PHKG10.34338730
99CHUK0.33698797
100CSNK1A10.33449102

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.37736629
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.38695076
3Mismatch repair_Homo sapiens_hsa034303.10107409
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.98101548
5Proteasome_Homo sapiens_hsa030502.94157471
6Spliceosome_Homo sapiens_hsa030402.93172396
7RNA polymerase_Homo sapiens_hsa030202.85311461
8DNA replication_Homo sapiens_hsa030302.69472212
9Homologous recombination_Homo sapiens_hsa034402.63919860
10Oxidative phosphorylation_Homo sapiens_hsa001902.60055818
11RNA transport_Homo sapiens_hsa030132.51744612
12Nucleotide excision repair_Homo sapiens_hsa034202.48394130
13Non-homologous end-joining_Homo sapiens_hsa034502.36026203
14RNA degradation_Homo sapiens_hsa030182.30551861
15Basal transcription factors_Homo sapiens_hsa030222.26838910
16Fanconi anemia pathway_Homo sapiens_hsa034602.25623532
17One carbon pool by folate_Homo sapiens_hsa006702.17127713
18Parkinsons disease_Homo sapiens_hsa050122.14836991
19Systemic lupus erythematosus_Homo sapiens_hsa053222.04179138
20Base excision repair_Homo sapiens_hsa034101.95061805
21Ribosome_Homo sapiens_hsa030101.87139366
22Selenocompound metabolism_Homo sapiens_hsa004501.86378848
23Huntingtons disease_Homo sapiens_hsa050161.72787178
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54840347
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52473582
26Pyrimidine metabolism_Homo sapiens_hsa002401.51761770
27Alcoholism_Homo sapiens_hsa050341.50692834
28Regulation of autophagy_Homo sapiens_hsa041401.38934247
29Alzheimers disease_Homo sapiens_hsa050101.36501137
30Phototransduction_Homo sapiens_hsa047441.29748654
31mRNA surveillance pathway_Homo sapiens_hsa030151.25177483
32Cell cycle_Homo sapiens_hsa041101.23187222
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22737674
34Purine metabolism_Homo sapiens_hsa002301.20106697
35Propanoate metabolism_Homo sapiens_hsa006401.18469200
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13634394
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12868678
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.11756733
39Vitamin B6 metabolism_Homo sapiens_hsa007501.11520681
40Oocyte meiosis_Homo sapiens_hsa041141.02053705
41Folate biosynthesis_Homo sapiens_hsa007901.01969661
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99369107
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99277691
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94715809
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93395994
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91714571
47Nicotine addiction_Homo sapiens_hsa050330.90871487
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90477545
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84064755
50Butanoate metabolism_Homo sapiens_hsa006500.79530528
51Cardiac muscle contraction_Homo sapiens_hsa042600.78063747
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.75182367
53Fatty acid elongation_Homo sapiens_hsa000620.68815190
54Viral carcinogenesis_Homo sapiens_hsa052030.62830708
55Carbon metabolism_Homo sapiens_hsa012000.58972511
56Circadian rhythm_Homo sapiens_hsa047100.55552346
57Epstein-Barr virus infection_Homo sapiens_hsa051690.54273142
58Metabolic pathways_Homo sapiens_hsa011000.50362085
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49660991
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49210179
61p53 signaling pathway_Homo sapiens_hsa041150.48901403
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47549111
63Type I diabetes mellitus_Homo sapiens_hsa049400.44237224
64Biosynthesis of amino acids_Homo sapiens_hsa012300.43123625
65N-Glycan biosynthesis_Homo sapiens_hsa005100.42847711
66Peroxisome_Homo sapiens_hsa041460.41308930
67Pyruvate metabolism_Homo sapiens_hsa006200.38465462
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35056265
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34293060
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34113054
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34100519
72Steroid biosynthesis_Homo sapiens_hsa001000.33751556
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33631695
74Collecting duct acid secretion_Homo sapiens_hsa049660.32323356
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30166307
76Sulfur relay system_Homo sapiens_hsa041220.29061208
77Glutathione metabolism_Homo sapiens_hsa004800.24087125
78Tight junction_Homo sapiens_hsa045300.23910082
79Antigen processing and presentation_Homo sapiens_hsa046120.23516624
80Herpes simplex infection_Homo sapiens_hsa051680.23452405
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23059529
82Lysine degradation_Homo sapiens_hsa003100.22906728
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.22889134
84Olfactory transduction_Homo sapiens_hsa047400.22445053
85Taste transduction_Homo sapiens_hsa047420.19083428
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18778599
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18278613
88Galactose metabolism_Homo sapiens_hsa000520.17236775
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15503065
90TGF-beta signaling pathway_Homo sapiens_hsa043500.15490506
91Dopaminergic synapse_Homo sapiens_hsa047280.13872319
92Hedgehog signaling pathway_Homo sapiens_hsa043400.12565399
93Synaptic vesicle cycle_Homo sapiens_hsa047210.12484989
94Shigellosis_Homo sapiens_hsa051310.07964000
95Primary immunodeficiency_Homo sapiens_hsa053400.07557355
96Hippo signaling pathway_Homo sapiens_hsa043900.07297234
97Insulin secretion_Homo sapiens_hsa049110.06741640
98Nitrogen metabolism_Homo sapiens_hsa009100.05675436
99Adherens junction_Homo sapiens_hsa045200.05628907
100GABAergic synapse_Homo sapiens_hsa047270.05067476

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