TCEA1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)9.96229573
2regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)9.96229573
3regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033398.75265913
4regulation of vitamin D biosynthetic process (GO:0060556)7.49222258
5regulation of podosome assembly (GO:0071801)7.25889943
6regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)7.18869453
7regulation of interleukin-12 biosynthetic process (GO:0045075)6.56464834
8negative regulation of metanephros development (GO:0072217)6.26036862
9positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)5.93715746
10regulation of vitamin metabolic process (GO:0030656)5.53804055
11response to pheromone (GO:0019236)5.27486684
12regulation of centriole replication (GO:0046599)5.21660022
13positive regulation of chemokine biosynthetic process (GO:0045080)5.13272082
14regulation of isotype switching to IgG isotypes (GO:0048302)5.10530367
15regulation of MHC class II biosynthetic process (GO:0045346)5.07678817
16negative regulation of interleukin-17 production (GO:0032700)4.68817258
17positive regulation of alcohol biosynthetic process (GO:1902932)4.48126128
18negative regulation of neurological system process (GO:0031645)4.37230304
19centriole assembly (GO:0098534)4.25354313
20transcription elongation from RNA polymerase I promoter (GO:0006362)4.18979334
21positive regulation of osteoclast differentiation (GO:0045672)4.18408413
22regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.14574163
23single strand break repair (GO:0000012)4.13448835
24positive regulation of steroid biosynthetic process (GO:0010893)4.04158511
25leukocyte apoptotic process (GO:0071887)4.02237826
26regulation of chemokine biosynthetic process (GO:0045073)3.98664216
27regulation of RNA export from nucleus (GO:0046831)3.94132722
28positive regulation of organelle assembly (GO:1902117)3.91895979
29termination of RNA polymerase I transcription (GO:0006363)3.79850505
30nuclear pore complex assembly (GO:0051292)3.74729471
31peptidyl-histidine modification (GO:0018202)3.71194354
32maturation of 5.8S rRNA (GO:0000460)3.69711682
33spindle assembly involved in mitosis (GO:0090307)3.61722847
34inositol phosphate dephosphorylation (GO:0046855)3.59898209
35phosphorylated carbohydrate dephosphorylation (GO:0046838)3.59898209
36protein K6-linked ubiquitination (GO:0085020)3.59883357
37positive regulation of muscle cell apoptotic process (GO:0010661)3.58071853
38regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.51161979
39ribosome assembly (GO:0042255)3.48085494
40hindbrain development (GO:0030902)3.47850987
41transcription initiation from RNA polymerase I promoter (GO:0006361)3.39817061
42regulation of smooth muscle cell apoptotic process (GO:0034391)3.38315245
43regulation of DNA endoreduplication (GO:0032875)3.25854574
44negative regulation of kidney development (GO:0090185)3.24416962
45positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.24352426
46negative regulation of translation, ncRNA-mediated (GO:0040033)3.22256344
47regulation of translation, ncRNA-mediated (GO:0045974)3.22256344
48negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.22256344
49positive regulation of isotype switching (GO:0045830)3.21779017
50myeloid dendritic cell differentiation (GO:0043011)3.18619451
51regulation of interleukin-6 biosynthetic process (GO:0045408)3.18237055
52cytoplasmic mRNA processing body assembly (GO:0033962)3.16235230
53alpha-beta T cell differentiation involved in immune response (GO:0002293)3.13213158
54alpha-beta T cell activation involved in immune response (GO:0002287)3.13213158
55T cell differentiation involved in immune response (GO:0002292)3.13213158
56regulation of centrosome duplication (GO:0010824)3.09708595
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.09416757
58ribonucleoprotein complex disassembly (GO:0032988)3.08979220
59nuclear pore organization (GO:0006999)3.07363135
60inositol phosphate catabolic process (GO:0071545)3.06779459
61positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.05558801
62regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.05287816
63motile cilium assembly (GO:0044458)3.03046528
64metaphase plate congression (GO:0051310)2.99517541
65positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.97160333
66positive regulation of monooxygenase activity (GO:0032770)2.96930330
67regulation of isotype switching (GO:0045191)2.96683047
68microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.93811367
69defense response to protozoan (GO:0042832)2.93531581
70centriole replication (GO:0007099)2.93337731
71positive regulation of DNA recombination (GO:0045911)2.92713373
72transcription from RNA polymerase I promoter (GO:0006360)2.92221661
73nucleotide transmembrane transport (GO:1901679)2.91885118
74mitotic sister chromatid cohesion (GO:0007064)2.87233887
75regulation of centrosome cycle (GO:0046605)2.86330837
76non-recombinational repair (GO:0000726)2.86132087
77double-strand break repair via nonhomologous end joining (GO:0006303)2.86132087
78regulation of nucleobase-containing compound transport (GO:0032239)2.85767183
79cilium or flagellum-dependent cell motility (GO:0001539)2.85393074
80cellular response to ATP (GO:0071318)2.84234366
81mitotic metaphase plate congression (GO:0007080)2.84129951
82uterus development (GO:0060065)2.83193088
83pore complex assembly (GO:0046931)2.80694581
84monoubiquitinated protein deubiquitination (GO:0035520)2.78964938
85folic acid-containing compound biosynthetic process (GO:0009396)2.77629008
86regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.75904221
87somatic hypermutation of immunoglobulin genes (GO:0016446)2.74204892
88somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74204892
89DNA damage response, detection of DNA damage (GO:0042769)2.69063767
90regulation of response to interferon-gamma (GO:0060330)2.67805528
91T cell lineage commitment (GO:0002360)2.67471843
92modulation of growth of symbiont involved in interaction with host (GO:0044144)2.65088144
93regulation of growth of symbiont in host (GO:0044126)2.65088144
94negative regulation of growth of symbiont in host (GO:0044130)2.65088144
95negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.65088144
96somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.61922123
97somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.61922123
98isotype switching (GO:0045190)2.61922123
99positive regulation of interleukin-12 production (GO:0032735)2.61216451
100regulation of metanephros development (GO:0072215)2.60487176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.24088298
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.37862371
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.33868075
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.26227655
5ELK1_19687146_ChIP-ChIP_HELA_Human3.25646242
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99698518
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.86955372
8E2F7_22180533_ChIP-Seq_HELA_Human2.85777252
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.76706512
10PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.76151060
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70401061
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.51874939
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.50316606
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39540375
15DCP1A_22483619_ChIP-Seq_HELA_Human2.29574110
16VDR_23849224_ChIP-Seq_CD4+_Human2.23671415
17PADI4_21655091_ChIP-ChIP_MCF-7_Human2.09340445
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09289411
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08575452
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07153759
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.06309480
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.06158877
23EWS_26573619_Chip-Seq_HEK293_Human2.03820246
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03133749
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97359018
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.94895259
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93809565
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.92849876
29GABP_19822575_ChIP-Seq_HepG2_Human1.88170010
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87077889
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80249277
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74537310
33FOXP3_21729870_ChIP-Seq_TREG_Human1.73188789
34TAF15_26573619_Chip-Seq_HEK293_Human1.69118448
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.67279443
36MYC_18940864_ChIP-ChIP_HL60_Human1.59604708
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.58947176
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53330853
39TP53_16413492_ChIP-PET_HCT116_Human1.48638251
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48414659
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46580061
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43269946
43ZNF274_21170338_ChIP-Seq_K562_Hela1.40705846
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37921942
45FUS_26573619_Chip-Seq_HEK293_Human1.34720994
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34603846
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34027009
48IRF1_19129219_ChIP-ChIP_H3396_Human1.33866109
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32829892
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32332323
51VDR_22108803_ChIP-Seq_LS180_Human1.32010068
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31762273
53TFEB_21752829_ChIP-Seq_HELA_Human1.31106575
54TTF2_22483619_ChIP-Seq_HELA_Human1.30484563
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30225608
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28729812
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.27622134
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26499955
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24290775
60ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21153852
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20401778
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19984351
63FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.15658888
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14803769
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.11614940
66TP53_18474530_ChIP-ChIP_U2OS_Human1.11506828
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11442767
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10824082
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10514336
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08818364
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08498114
72KDM5A_27292631_Chip-Seq_BREAST_Human1.03697841
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03147807
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.02072530
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01709433
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.01446916
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01300816
78FOXM1_23109430_ChIP-Seq_U2OS_Human1.00962448
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00688101
80PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99617078
81SOX2_18555785_Chip-Seq_ESCs_Mouse0.99528174
82ELF5_23300383_ChIP-Seq_T47D_Human0.98619878
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.97710390
84CRX_20693478_ChIP-Seq_RETINA_Mouse0.96551287
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96355201
86AR_21909140_ChIP-Seq_LNCAP_Human0.95826579
87BRD4_25478319_ChIP-Seq_HGPS_Human0.95113694
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94674178
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94571715
90LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93844526
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93679663
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.93213805
93MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93021825
94ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92061074
95P300_19829295_ChIP-Seq_ESCs_Human0.91482300
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91172882
97NMYC_18555785_Chip-Seq_ESCs_Mouse0.90045967
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.88421014
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.88375723
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87699338

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation5.78263848
2MP0010307_abnormal_tumor_latency4.41396787
3MP0008058_abnormal_DNA_repair3.34151296
4MP0001835_abnormal_antigen_presentation3.31245329
5MP0001986_abnormal_taste_sensitivity3.24989442
6MP0009697_abnormal_copulation3.22105027
7MP0004782_abnormal_surfactant_physiolog2.96419226
8MP0003186_abnormal_redox_activity2.87019169
9MP0010094_abnormal_chromosome_stability2.86613859
10MP0003195_calcinosis2.70926523
11MP0009780_abnormal_chondrocyte_physiolo2.65504950
12MP0003111_abnormal_nucleus_morphology2.47224481
13MP0008057_abnormal_DNA_replication2.44890573
14MP0004957_abnormal_blastocyst_morpholog2.21787131
15MP0000427_abnormal_hair_cycle2.14969112
16MP0002254_reproductive_system_inflammat2.05695438
17MP0005187_abnormal_penis_morphology2.00746809
18MP0003787_abnormal_imprinting2.00605583
19MP0001958_emphysema1.94958579
20MP0003121_genomic_imprinting1.94531152
21MP0003123_paternal_imprinting1.91663175
22MP0003786_premature_aging1.78647900
23MP0009333_abnormal_splenocyte_physiolog1.75939300
24MP0003315_abnormal_perineum_morphology1.75340328
25MP0003950_abnormal_plasma_membrane1.69850593
26MP0003890_abnormal_embryonic-extraembry1.65442446
27MP0001666_abnormal_nutrient_absorption1.63541286
28MP0008877_abnormal_DNA_methylation1.57782795
29MP0003868_abnormal_feces_composition1.50094139
30MP0006035_abnormal_mitochondrial_morpho1.49102931
31MP0003077_abnormal_cell_cycle1.46562451
32MP0002909_abnormal_adrenal_gland1.42081340
33MP0006054_spinal_hemorrhage1.41258423
34MP0004197_abnormal_fetal_growth/weight/1.39017820
35MP0008995_early_reproductive_senescence1.38396821
36MP0004133_heterotaxia1.38253556
37MP0002405_respiratory_system_inflammati1.34461027
38MP0002332_abnormal_exercise_endurance1.31094289
39MP0003221_abnormal_cardiomyocyte_apopto1.27812708
40MP0002693_abnormal_pancreas_physiology1.23282812
41MP0000639_abnormal_adrenal_gland1.21629641
42MP0005084_abnormal_gallbladder_morpholo1.14718763
43MP0003693_abnormal_embryo_hatching1.14167158
44MP0006036_abnormal_mitochondrial_physio1.13966745
45MP0001881_abnormal_mammary_gland1.12543646
46MP0001764_abnormal_homeostasis1.12472718
47MP0002234_abnormal_pharynx_morphology1.08920252
48MP0000358_abnormal_cell_content/1.07615981
49MP0005671_abnormal_response_to1.04285988
50MP0005389_reproductive_system_phenotype1.03893285
51MP0001919_abnormal_reproductive_system1.03011224
52MP0009703_decreased_birth_body1.02212787
53MP0003936_abnormal_reproductive_system1.01612660
54MP0006072_abnormal_retinal_apoptosis0.99158973
55MP0005647_abnormal_sex_gland0.97652512
56MP0009785_altered_susceptibility_to0.97311386
57MP0004142_abnormal_muscle_tone0.96268235
58MP0003252_abnormal_bile_duct0.95812662
59MP0001697_abnormal_embryo_size0.94463100
60MP0001119_abnormal_female_reproductive0.91957927
61MP0008872_abnormal_physiological_respon0.89736846
62MP0005501_abnormal_skin_physiology0.88743900
63MP0002210_abnormal_sex_determination0.86785550
64MP0008007_abnormal_cellular_replicative0.85456705
65MP0002084_abnormal_developmental_patter0.84739844
66MP0005451_abnormal_body_composition0.84448669
67MP0001968_abnormal_touch/_nociception0.83043635
68MP0002876_abnormal_thyroid_physiology0.81593048
69MP0000013_abnormal_adipose_tissue0.81553270
70MP0003656_abnormal_erythrocyte_physiolo0.80071585
71MP0008004_abnormal_stomach_pH0.79877556
72MP0003806_abnormal_nucleotide_metabolis0.78747689
73MP0005646_abnormal_pituitary_gland0.78676999
74MP0005408_hypopigmentation0.78557624
75MP0000653_abnormal_sex_gland0.77272422
76MP0005266_abnormal_metabolism0.77174185
77MP0002086_abnormal_extraembryonic_tissu0.72150167
78MP0008932_abnormal_embryonic_tissue0.70107422
79MP0002928_abnormal_bile_duct0.70029013
80MP0009672_abnormal_birth_weight0.69467916
81MP0008961_abnormal_basal_metabolism0.69214892
82MP0005380_embryogenesis_phenotype0.69072887
83MP0001672_abnormal_embryogenesis/_devel0.69072887
84MP0003119_abnormal_digestive_system0.68849606
85MP0002933_joint_inflammation0.67865177
86MP0004147_increased_porphyrin_level0.65619393
87MP0002019_abnormal_tumor_incidence0.64965613
88MP0000350_abnormal_cell_proliferation0.64307529
89MP0000647_abnormal_sebaceous_gland0.63637862
90MP0002160_abnormal_reproductive_system0.63018795
91MP0003984_embryonic_growth_retardation0.62263060
92MP0003699_abnormal_female_reproductive0.61714124
93MP0002136_abnormal_kidney_physiology0.61171734
94MP0003755_abnormal_palate_morphology0.60322980
95MP0003646_muscle_fatigue0.60252272
96MP0005253_abnormal_eye_physiology0.60125046
97MP0000313_abnormal_cell_death0.60109513
98MP0001929_abnormal_gametogenesis0.57348766
99MP0010329_abnormal_lipoprotein_level0.57142070
100MP0002735_abnormal_chemical_nociception0.56169597

Predicted human phenotypes

RankGene SetZ-score
1Protruding tongue (HP:0010808)5.00394576
2Chronic otitis media (HP:0000389)4.35289220
3Gonadotropin excess (HP:0000837)4.28837020
4Fair hair (HP:0002286)4.18254487
5Abnormality of the pons (HP:0007361)3.74846569
6Volvulus (HP:0002580)3.54233451
7Irregular vertebral endplates (HP:0003301)3.42808528
8Broad-based gait (HP:0002136)3.40323425
9Abnormality of alanine metabolism (HP:0010916)3.33691502
10Hyperalaninemia (HP:0003348)3.33691502
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.33691502
12Hypoplasia of the pons (HP:0012110)3.30627744
13Chronic sinusitis (HP:0011109)3.28091366
14Abnormal respiratory motile cilium morphology (HP:0005938)3.11251501
15Abnormal respiratory epithelium morphology (HP:0012253)3.11251501
16Hyperventilation (HP:0002883)3.04674909
17Chromsome breakage (HP:0040012)3.04252288
18Progressive inability to walk (HP:0002505)3.00297493
19Gaze-evoked nystagmus (HP:0000640)2.99552783
20Inappropriate behavior (HP:0000719)2.95259900
21Abnormality of chromosome stability (HP:0003220)2.87482878
22Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.82650074
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77237951
24Flat occiput (HP:0005469)2.73246547
25Progressive external ophthalmoplegia (HP:0000590)2.72155056
26Generalized hypopigmentation of hair (HP:0011358)2.62179645
27Meckel diverticulum (HP:0002245)2.55277010
28Widely spaced teeth (HP:0000687)2.48435371
29Papillary thyroid carcinoma (HP:0002895)2.47361207
30Vertebral arch anomaly (HP:0008438)2.43368321
31Abnormality of the vertebral endplates (HP:0005106)2.43170804
32Pancreatic cysts (HP:0001737)2.43057277
33IgA deficiency (HP:0002720)2.39890773
34Abnormality of the ileum (HP:0001549)2.37621483
35Clumsiness (HP:0002312)2.36141584
36Cutaneous melanoma (HP:0012056)2.35228833
37Curly hair (HP:0002212)2.34697640
38Menstrual irregularities (HP:0000858)2.31964302
39Aplastic anemia (HP:0001915)2.28856695
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.27191659
41Entropion (HP:0000621)2.26508234
42Metaphyseal irregularity (HP:0003025)2.26392658
43Abnormality of the preputium (HP:0100587)2.24974536
44Drooling (HP:0002307)2.22737707
45Enlarged penis (HP:0000040)2.22681703
46Secondary amenorrhea (HP:0000869)2.16209460
47Exotropia (HP:0000577)2.14066236
48Posterior subcapsular cataract (HP:0007787)2.12995129
49Aplasia/hypoplasia of the uterus (HP:0008684)2.11375629
50Chorioretinal atrophy (HP:0000533)2.10849210
51Intellectual disability, progressive (HP:0006887)2.09550612
52Abnormality of renal resorption (HP:0011038)2.04717486
53Attenuation of retinal blood vessels (HP:0007843)2.04472413
54Carpal bone hypoplasia (HP:0001498)2.01915249
55Abnormality of methionine metabolism (HP:0010901)2.00588789
56Medial flaring of the eyebrow (HP:0010747)1.99499612
57Excessive salivation (HP:0003781)1.98750831
58Septate vagina (HP:0001153)1.97899607
59Horizontal nystagmus (HP:0000666)1.96740816
60Increased hepatocellular lipid droplets (HP:0006565)1.96719384
61Inability to walk (HP:0002540)1.95798100
62Lipid accumulation in hepatocytes (HP:0006561)1.87990459
63Acute necrotizing encephalopathy (HP:0006965)1.87280259
64Thyroid carcinoma (HP:0002890)1.86918251
65Gait ataxia (HP:0002066)1.86726680
66Hypergonadotropic hypogonadism (HP:0000815)1.85667518
67Primitive neuroectodermal tumor (HP:0030065)1.84824825
68Neuroblastic tumors (HP:0004376)1.84824825
69Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.84824825
70Neuroblastoma (HP:0003006)1.84824825
71Absent speech (HP:0001344)1.82937665
72Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82156673
73Sclerocornea (HP:0000647)1.81477847
74Unilateral renal agenesis (HP:0000122)1.81054161
75Renal cortical cysts (HP:0000803)1.80635649
76Sensory axonal neuropathy (HP:0003390)1.79476330
77Abnormality of macular pigmentation (HP:0008002)1.78786232
78Microretrognathia (HP:0000308)1.77402654
79Truncal obesity (HP:0001956)1.75641098
80Ulnar bowing (HP:0003031)1.74467680
81Subcapsular cataract (HP:0000523)1.74353586
82Aplasia cutis congenita (HP:0001057)1.72397550
83Glucose intolerance (HP:0000833)1.71749571
84Increased serum lactate (HP:0002151)1.71641030
85Intestinal fistula (HP:0100819)1.71595645
86Acute encephalopathy (HP:0006846)1.70574425
87Abnormality of the renal cortex (HP:0011035)1.70019694
88Poikiloderma (HP:0001029)1.69957542
89Molar tooth sign on MRI (HP:0002419)1.68948011
90Abnormality of midbrain morphology (HP:0002418)1.68948011
91Abnormality of calcium-phosphate metabolism (HP:0100530)1.68686290
92Myelodysplasia (HP:0002863)1.68586816
93Duodenal stenosis (HP:0100867)1.68057871
94Small intestinal stenosis (HP:0012848)1.68057871
95Increased CSF lactate (HP:0002490)1.68012122
96Pancreatic fibrosis (HP:0100732)1.67376622
97Deep philtrum (HP:0002002)1.62991831
98Biconcave vertebral bodies (HP:0004586)1.62430111
99Sloping forehead (HP:0000340)1.61908485
100Coarctation of aorta (HP:0001680)1.61408999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.16872428
2EIF2AK34.27015793
3CASK4.14097010
4BRD43.12636931
5PINK12.91027457
6EIF2AK12.78046745
7MKNK22.75936129
8NME12.60600109
9BRSK22.59102289
10SRPK12.17785010
11MKNK12.12496462
12AKT32.08841104
13INSRR2.02824920
14MAP3K61.97131210
15MAP4K21.94210246
16PLK41.90792257
17PLK21.85919074
18TXK1.81865682
19TTK1.80588267
20MAP2K61.68894970
21MAP3K41.63775054
22TSSK61.53280801
23PBK1.38285714
24PLK31.38222061
25TRIM281.36808289
26FLT31.36773240
27FRK1.33566589
28ERBB31.27380131
29PKN21.24023134
30BUB11.23808081
31MAP3K51.18028407
32PLK11.12276379
33ZAK1.12160627
34WNK11.10753456
35MELK1.09924435
36BRSK11.08248389
37FGFR11.01860624
38CAMK1D1.01738042
39BMPR1B0.99781638
40STK100.98672582
41ALK0.98568929
42PDK20.97954900
43EPHA20.93511842
44CHEK20.90241835
45ACVR1B0.85912674
46EIF2AK20.80232468
47GRK10.78925346
48NEK60.78107394
49BCR0.76413559
50CAMKK20.76078984
51MST1R0.74819474
52PRKCE0.72837438
53NEK90.72677970
54PASK0.72647361
55MAP2K30.70001719
56PAK30.69757098
57TNK20.69635268
58TNIK0.66207666
59STK380.65806747
60STK40.65656158
61ATM0.65299756
62NEK10.65223112
63WNK40.62662614
64ATR0.60374341
65TAF10.57909513
66CHEK10.57342292
67LATS20.55852570
68ICK0.55822303
69MAP3K70.55123346
70CAMK1G0.53255850
71ADRBK10.53100371
72WEE10.52443011
73RPS6KA40.51823277
74CHUK0.51119488
75MAP2K40.50227379
76CDK40.50180283
77AURKB0.49579361
78ADRBK20.48122353
79PRKCI0.47635269
80ERBB40.45875073
81PDGFRB0.45087075
82DDR20.42901500
83SIK30.42183401
84TGFBR10.41579432
85MAP3K140.37915389
86LRRK20.36660009
87CDC70.36636209
88CDK70.35072692
89DYRK30.34692257
90WNK30.33848829
91EPHB10.31341828
92CCNB10.31101617
93MET0.30482657
94IRAK30.30161472
95CDK60.29280789
96CSNK2A10.29038859
97IRAK10.28940864
98CDK20.28050050
99NLK0.28039250
100FGR0.27605255

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.63723428
2Protein export_Homo sapiens_hsa030603.52621820
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.47895766
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.34011277
5Non-homologous end-joining_Homo sapiens_hsa034503.18307051
6Selenocompound metabolism_Homo sapiens_hsa004502.77903515
7RNA polymerase_Homo sapiens_hsa030202.68978058
8Homologous recombination_Homo sapiens_hsa034402.62855571
9Basal transcription factors_Homo sapiens_hsa030222.53517255
10Regulation of autophagy_Homo sapiens_hsa041402.52867107
11Fanconi anemia pathway_Homo sapiens_hsa034602.50522587
12RNA degradation_Homo sapiens_hsa030182.27719406
13Nucleotide excision repair_Homo sapiens_hsa034202.13584423
14Mismatch repair_Homo sapiens_hsa034302.10741573
15RNA transport_Homo sapiens_hsa030132.09483234
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.04792185
17Spliceosome_Homo sapiens_hsa030402.04690859
18One carbon pool by folate_Homo sapiens_hsa006701.92276166
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77108911
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.75975738
21African trypanosomiasis_Homo sapiens_hsa051431.61557066
22Rheumatoid arthritis_Homo sapiens_hsa053231.55726017
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55629760
24Cell cycle_Homo sapiens_hsa041101.55417176
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.50310544
26TGF-beta signaling pathway_Homo sapiens_hsa043501.39212946
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.35387205
28DNA replication_Homo sapiens_hsa030301.29649718
29Steroid biosynthesis_Homo sapiens_hsa001001.29055541
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28201552
31Base excision repair_Homo sapiens_hsa034101.20717366
32Sulfur metabolism_Homo sapiens_hsa009201.17937310
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05553748
34T cell receptor signaling pathway_Homo sapiens_hsa046601.04803977
35Pyrimidine metabolism_Homo sapiens_hsa002401.03844154
36mRNA surveillance pathway_Homo sapiens_hsa030151.02525052
37Malaria_Homo sapiens_hsa051441.02120582
38Type I diabetes mellitus_Homo sapiens_hsa049401.01681037
39Butanoate metabolism_Homo sapiens_hsa006500.98371523
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96386939
41Oxidative phosphorylation_Homo sapiens_hsa001900.93681572
42Caffeine metabolism_Homo sapiens_hsa002320.91220016
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91203697
44Circadian rhythm_Homo sapiens_hsa047100.87546240
45Salmonella infection_Homo sapiens_hsa051320.86981755
46Purine metabolism_Homo sapiens_hsa002300.79928220
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79499715
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79343259
49p53 signaling pathway_Homo sapiens_hsa041150.79140510
50Allograft rejection_Homo sapiens_hsa053300.72669137
51Measles_Homo sapiens_hsa051620.71201219
52Ribosome_Homo sapiens_hsa030100.66003798
53Fatty acid biosynthesis_Homo sapiens_hsa000610.65643923
54Lysine degradation_Homo sapiens_hsa003100.61901597
55HIF-1 signaling pathway_Homo sapiens_hsa040660.60755315
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60504331
57Folate biosynthesis_Homo sapiens_hsa007900.60283996
58Nitrogen metabolism_Homo sapiens_hsa009100.58625103
59Taste transduction_Homo sapiens_hsa047420.58469003
60TNF signaling pathway_Homo sapiens_hsa046680.57933858
61Pyruvate metabolism_Homo sapiens_hsa006200.56251466
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54941481
63Mineral absorption_Homo sapiens_hsa049780.54507796
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54396019
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53107806
66Epstein-Barr virus infection_Homo sapiens_hsa051690.52825555
67Linoleic acid metabolism_Homo sapiens_hsa005910.52600318
68N-Glycan biosynthesis_Homo sapiens_hsa005100.52123478
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50682322
70Collecting duct acid secretion_Homo sapiens_hsa049660.48074585
71Hematopoietic cell lineage_Homo sapiens_hsa046400.48073417
72Huntingtons disease_Homo sapiens_hsa050160.46920958
73Parkinsons disease_Homo sapiens_hsa050120.45116495
74Peroxisome_Homo sapiens_hsa041460.44826102
75Herpes simplex infection_Homo sapiens_hsa051680.41878447
76Metabolic pathways_Homo sapiens_hsa011000.41364934
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41049622
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40912819
79Propanoate metabolism_Homo sapiens_hsa006400.40462367
80Inositol phosphate metabolism_Homo sapiens_hsa005620.40392304
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38601120
82Sphingolipid metabolism_Homo sapiens_hsa006000.38189736
83Ether lipid metabolism_Homo sapiens_hsa005650.33961887
84Amoebiasis_Homo sapiens_hsa051460.33739707
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33454457
86Fatty acid metabolism_Homo sapiens_hsa012120.33264138
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32353667
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31883129
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31014657
90Glutathione metabolism_Homo sapiens_hsa004800.29243741
91Oocyte meiosis_Homo sapiens_hsa041140.28984535
92Fatty acid elongation_Homo sapiens_hsa000620.28560861
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27914089
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27324061
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24699082
96Graft-versus-host disease_Homo sapiens_hsa053320.21647417
97Starch and sucrose metabolism_Homo sapiens_hsa005000.20808447
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.18607965
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16067173
100Adherens junction_Homo sapiens_hsa045200.15417926

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