TCEA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.95748222
2sperm motility (GO:0030317)8.90139510
3fusion of sperm to egg plasma membrane (GO:0007342)8.72834468
4acrosome reaction (GO:0007340)8.42127882
5acrosome assembly (GO:0001675)8.00342675
6sperm-egg recognition (GO:0035036)7.27700510
7axonemal dynein complex assembly (GO:0070286)7.23413704
8cell wall macromolecule metabolic process (GO:0044036)7.13560268
9cell wall macromolecule catabolic process (GO:0016998)7.13560268
10epithelial cilium movement (GO:0003351)7.09611782
11plasma membrane fusion (GO:0045026)7.06066013
12spermatid development (GO:0007286)6.77299497
13multicellular organism reproduction (GO:0032504)6.77243465
14piRNA metabolic process (GO:0034587)6.76995270
15binding of sperm to zona pellucida (GO:0007339)6.70384285
16motile cilium assembly (GO:0044458)6.57870519
17cell-cell recognition (GO:0009988)6.49904622
18regulation of cilium movement (GO:0003352)6.30564558
19cilium movement (GO:0003341)6.29486399
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.11358575
21male meiosis (GO:0007140)5.90313598
22synaptonemal complex organization (GO:0070193)5.70506209
23reproduction (GO:0000003)5.57778674
24negative regulation of inclusion body assembly (GO:0090084)5.36054886
25calcium ion-dependent exocytosis (GO:0017156)5.31915949
26synaptonemal complex assembly (GO:0007130)5.19907936
27postsynaptic membrane organization (GO:0001941)4.78962199
28single fertilization (GO:0007338)4.73906368
29sperm capacitation (GO:0048240)4.73647522
30protein localization to cilium (GO:0061512)4.62732628
31regulation of inclusion body assembly (GO:0090083)4.49801271
32DNA methylation involved in gamete generation (GO:0043046)4.45980576
33spermatogenesis (GO:0007283)4.28357731
34male gamete generation (GO:0048232)4.26366286
35ventricular system development (GO:0021591)4.16978314
36male meiosis I (GO:0007141)4.14102147
37regulation of microtubule-based movement (GO:0060632)4.09814673
38cell migration in hindbrain (GO:0021535)4.07475936
39positive regulation of synapse maturation (GO:0090129)4.06450224
40fertilization (GO:0009566)4.05550887
41establishment of mitochondrion localization (GO:0051654)3.95668424
42gamete generation (GO:0007276)3.90952798
43cell recognition (GO:0008037)3.89899844
44protein polyglutamylation (GO:0018095)3.84826913
45regulation of synapse structural plasticity (GO:0051823)3.84577128
46germ cell development (GO:0007281)3.82476273
47neuronal ion channel clustering (GO:0045161)3.81461142
48microtubule severing (GO:0051013)3.80050947
49cellular process involved in reproduction in multicellular organism (GO:0022412)3.77773445
50protein localization to synapse (GO:0035418)3.76619856
51sodium ion export (GO:0071436)3.71363197
52left/right pattern formation (GO:0060972)3.71310327
53regulation of short-term neuronal synaptic plasticity (GO:0048172)3.69403819
54seminiferous tubule development (GO:0072520)3.67245009
55synaptic vesicle maturation (GO:0016188)3.66142826
56establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.63649179
57mitochondrion transport along microtubule (GO:0047497)3.63649179
58synaptic vesicle exocytosis (GO:0016079)3.63074821
59cerebellar granule cell differentiation (GO:0021707)3.61391387
60organic cation transport (GO:0015695)3.53969028
61intraciliary transport (GO:0042073)3.52395526
62regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.49260542
63locomotory exploration behavior (GO:0035641)3.49160578
64cellular potassium ion homeostasis (GO:0030007)3.48575145
65vocalization behavior (GO:0071625)3.45957639
66chromosome organization involved in meiosis (GO:0070192)3.44329508
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43770783
68membrane depolarization during action potential (GO:0086010)3.42727772
69axoneme assembly (GO:0035082)3.41961516
70neuron cell-cell adhesion (GO:0007158)3.40345447
71central nervous system myelination (GO:0022010)3.36662384
72axon ensheathment in central nervous system (GO:0032291)3.36662384
73positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.36487940
74exploration behavior (GO:0035640)3.36459032
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.35723607
76neurotransmitter-gated ion channel clustering (GO:0072578)3.34598246
77cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.34320233
78spermatid nucleus differentiation (GO:0007289)3.33408600
79positive regulation of membrane potential (GO:0045838)3.32952891
80meiotic nuclear division (GO:0007126)3.32058560
81microtubule depolymerization (GO:0007019)3.30858931
82glutamate secretion (GO:0014047)3.30513585
83positive regulation of dendritic spine development (GO:0060999)3.28661467
84regulation of synaptic vesicle exocytosis (GO:2000300)3.26351181
85neurotransmitter transport (GO:0006836)3.22965458
86regulation of long-term neuronal synaptic plasticity (GO:0048169)3.22062306
87cerebellar Purkinje cell layer development (GO:0021680)3.21634978
88meiosis I (GO:0007127)3.18700429
89regulation of neurotransmitter levels (GO:0001505)3.18282292
90layer formation in cerebral cortex (GO:0021819)3.16473406
91dendritic spine organization (GO:0097061)3.12707149
92positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.10935933
93neuronal action potential propagation (GO:0019227)3.10091376
94regulation of protein kinase A signaling (GO:0010738)3.08391448
95regulation of glutamate receptor signaling pathway (GO:1900449)3.07971794
96cell communication by electrical coupling (GO:0010644)3.06922769
97regulation of synapse maturation (GO:0090128)3.04996776
98multicellular organismal reproductive process (GO:0048609)3.04239268
99dendritic spine morphogenesis (GO:0060997)3.00834021
100microtubule-based movement (GO:0007018)3.00205981
101auditory behavior (GO:0031223)3.00189578
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98537544
103regulation of synaptic vesicle transport (GO:1902803)2.92483212
104regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.89409768
105neuromuscular process controlling balance (GO:0050885)2.87936651
106L-phenylalanine catabolic process (GO:0006559)2.87252195
107erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.87252195
108ionotropic glutamate receptor signaling pathway (GO:0035235)2.85785126
109neurotransmitter secretion (GO:0007269)2.85288893
110regulation of synaptic plasticity (GO:0048167)2.82087800
111cilium organization (GO:0044782)2.80542440
112transmission of nerve impulse (GO:0019226)2.79105131
113synaptic vesicle docking involved in exocytosis (GO:0016081)2.77847074
114polyol catabolic process (GO:0046174)2.77760908
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.77186397
116regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.76627056
117ATP hydrolysis coupled proton transport (GO:0015991)2.76062365
118energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.76062365
119regulation of neurotransmitter secretion (GO:0046928)2.74520883
120positive regulation of neurotransmitter transport (GO:0051590)2.74199519
121cilium assembly (GO:0042384)2.73345708
122presynaptic membrane assembly (GO:0097105)2.73144219
123protein retention in ER lumen (GO:0006621)2.73058650
124regulation of voltage-gated calcium channel activity (GO:1901385)2.72990874
125short-term memory (GO:0007614)2.68095334
126negative regulation of organelle assembly (GO:1902116)2.67897880
127positive regulation of dendritic spine morphogenesis (GO:0061003)2.67587737
128cranial nerve morphogenesis (GO:0021602)2.67232973
129lactate metabolic process (GO:0006089)2.65777294
130negative regulation of synaptic transmission, GABAergic (GO:0032229)2.65725627
131regulation of excitatory postsynaptic membrane potential (GO:0060079)2.65542936
132neuromuscular process controlling posture (GO:0050884)2.64491811
133presynaptic membrane organization (GO:0097090)2.64302763
134response to misfolded protein (GO:0051788)2.64100600
135L-phenylalanine metabolic process (GO:0006558)2.63015990
136erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.63015990
137positive regulation of dendrite development (GO:1900006)2.62968721
138protein refolding (GO:0042026)2.62640803
139calcium ion import (GO:0070509)2.62465597
140synaptic transmission, glutamatergic (GO:0035249)2.61764721
141deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.60057755
142regulation of neuronal synaptic plasticity (GO:0048168)2.59343008
143regulation of vesicle fusion (GO:0031338)2.57470897
144G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.57221273
145cellular component assembly involved in morphogenesis (GO:0010927)2.56878204
146amino acid import (GO:0043090)2.56372007
147regulation of neurotransmitter transport (GO:0051588)2.56200369
148gamma-aminobutyric acid transport (GO:0015812)2.55986206
149positive regulation of synapse assembly (GO:0051965)2.55619372
150positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.55309551
151establishment of synaptic vesicle localization (GO:0097480)2.55200677
152synaptic vesicle transport (GO:0048489)2.55200677
153regulation of respiratory system process (GO:0044065)2.54858076
154glutamate receptor signaling pathway (GO:0007215)2.54730775
155regulation of catecholamine metabolic process (GO:0042069)2.54528058
156regulation of dopamine metabolic process (GO:0042053)2.54528058
157response to auditory stimulus (GO:0010996)2.53900528
158mating behavior (GO:0007617)2.53410651
159nucleoside diphosphate phosphorylation (GO:0006165)2.52195039
160multicellular organismal development (GO:0007275)2.51313029
161mitochondrial fission (GO:0000266)2.50975648
162gamma-aminobutyric acid signaling pathway (GO:0007214)2.50765399
163axonal fasciculation (GO:0007413)2.50481455
164synaptic vesicle endocytosis (GO:0048488)2.50368723
165cilium morphogenesis (GO:0060271)2.50307554
166neuron-neuron synaptic transmission (GO:0007270)2.50305364
167pyrimidine nucleobase catabolic process (GO:0006208)2.49948673
168dicarboxylic acid transport (GO:0006835)2.49776190
169intraspecies interaction between organisms (GO:0051703)2.48192603
170social behavior (GO:0035176)2.48192603
171dopamine receptor signaling pathway (GO:0007212)2.47801358
172positive regulation of neurotransmitter secretion (GO:0001956)2.46667324
173adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.46139435
174neuromuscular synaptic transmission (GO:0007274)2.44994545
175neuron recognition (GO:0008038)2.44309642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.40474983
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.68480327
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.04427279
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.35016001
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.22287672
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71466704
7LXR_22292898_ChIP-Seq_THP-1_Human2.69035059
8REST_21632747_ChIP-Seq_MESCs_Mouse2.67757213
9ERG_21242973_ChIP-ChIP_JURKAT_Human2.43380362
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.33253005
11GBX2_23144817_ChIP-Seq_PC3_Human2.31646070
12ZNF274_21170338_ChIP-Seq_K562_Hela2.31245737
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30614802
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30150982
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.19181507
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.14623890
17CTCF_27219007_Chip-Seq_Bcells_Human2.10570728
18TAF15_26573619_Chip-Seq_HEK293_Human2.06318224
19DNAJC2_21179169_ChIP-ChIP_NT2_Human2.03835212
20P68_20966046_ChIP-Seq_HELA_Human2.03318928
21TET1_21451524_ChIP-Seq_MESCs_Mouse2.01524078
22SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.95148621
23* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.92897853
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91842197
25KDM2B_26808549_Chip-Seq_K562_Human1.89926764
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.88338606
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.81374252
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75613077
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74195904
30SMC4_20622854_ChIP-Seq_HELA_Human1.72051588
31SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.69005610
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68773296
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68334738
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68175030
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67623873
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66516402
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64385958
38SA1_27219007_Chip-Seq_ERYTHROID_Human1.63722896
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61290836
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.58837617
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.58663792
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57112839
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.56805705
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.56736996
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56718487
46VDR_22108803_ChIP-Seq_LS180_Human1.55438521
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.54352525
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.54296745
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.53588858
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.52973468
51* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49947872
52MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49483052
53RNF2_27304074_Chip-Seq_NSC_Mouse1.47667328
54SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.45451377
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45254696
56RACK7_27058665_Chip-Seq_MCF-7_Human1.44719582
57* KDM2B_26808549_Chip-Seq_DND41_Human1.43045893
58TET1_21490601_ChIP-Seq_MESCs_Mouse1.42110412
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41041845
60SMAD4_21799915_ChIP-Seq_A2780_Human1.39699790
61CBP_20019798_ChIP-Seq_JUKART_Human1.38676308
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38676308
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38402286
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38241201
65DROSHA_22980978_ChIP-Seq_HELA_Human1.37958649
66OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.37922561
67VDR_21846776_ChIP-Seq_THP-1_Human1.37484302
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.36104038
69MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.35916823
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35714700
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34686942
72CREB1_26743006_Chip-Seq_LNCaP_Human1.34498051
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.33732173
74CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33706037
75TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.33183521
76BCL6_27268052_Chip-Seq_Bcells_Human1.32625121
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32459033
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30585934
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29752379
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29128632
81* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.28322084
82KDM2B_26808549_Chip-Seq_REH_Human1.27823379
83* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27440393
84* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27228751
85* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26524081
86* FOXP1_21924763_ChIP-Seq_HESCs_Human1.26113574
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25152869
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24742975
89SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24089703
90ELK4_26923725_Chip-Seq_MESODERM_Mouse1.23932936
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22920543
92* ELK3_25401928_ChIP-Seq_HUVEC_Human1.22875348
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.21474765
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20415328
95SA1_27219007_Chip-Seq_Bcells_Human1.19931036
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19257159
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18815651
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18795126
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18413184
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17790943
101* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17324402
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.16303990
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15409601
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15022268
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14865510
106PHF8_20622854_ChIP-Seq_HELA_Human1.14713829
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.14645999
108CTCF_20526341_ChIP-Seq_ESCs_Human1.14409207
109WDR5_24793694_ChIP-Seq_LNCAP_Human1.14275701
110ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14025619
111BCOR_27268052_Chip-Seq_Bcells_Human1.12603093
112SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12384984
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.11793827
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11561644
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11528281
116FUS_26573619_Chip-Seq_HEK293_Human1.11301576
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11131148
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10930641
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10930641
120RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10541273
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10438035
122STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.09818949
123TCF4_23295773_ChIP-Seq_U87_Human1.08505278
124RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08376643
125EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08376643
126* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08161284
127OCT4_19829295_ChIP-Seq_ESCs_Human1.07618979
128E2F1_20622854_ChIP-Seq_HELA_Human1.07097508
129P300_19829295_ChIP-Seq_ESCs_Human1.06819605
130AR_25329375_ChIP-Seq_VCAP_Human1.05631183
131RARA_24833708_ChIP-Seq_LIVER_Mouse1.05245848
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04009859
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03637150
134ZNF263_19887448_ChIP-Seq_K562_Human1.03447524
135GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.03390785
136KDM2B_26808549_Chip-Seq_JURKAT_Human1.03380583
137SMAD3_21741376_ChIP-Seq_ESCs_Human1.03207116
138ER_23166858_ChIP-Seq_MCF-7_Human1.02855372
139SOX3_22085726_ChIP-Seq_NPCs_Mouse1.02751894
140SMAD3_21741376_ChIP-Seq_EPCs_Human1.02027831
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01466817
142CTCF_26484167_Chip-Seq_Bcells_Mouse1.01239595
143SOX9_26525672_Chip-Seq_HEART_Mouse1.01217948
144MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00203546
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99287321
146TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99157134
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98915429
148CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97572581
149P53_22387025_ChIP-Seq_ESCs_Mouse0.95719846
150POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95127584
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94954947
152STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94397103
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94234633
154TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94020860
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93598866
156EED_16625203_ChIP-ChIP_MESCs_Mouse0.92419087
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91393817
158BCAT_22108803_ChIP-Seq_LS180_Human0.90754473
159EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90210795
160NFE2_27457419_Chip-Seq_LIVER_Mouse0.88933549
161SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88581892
162PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88307930
163RING1B_27294783_Chip-Seq_ESCs_Mouse0.88077873
164CMYC_18555785_Chip-Seq_ESCs_Mouse0.87187770
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86903040
166STAT3_23295773_ChIP-Seq_U87_Human0.86397765
167GATA3_21867929_ChIP-Seq_CD8_Mouse0.86339572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.76091385
2MP0003880_abnormal_central_pattern4.06930467
3MP0004859_abnormal_synaptic_plasticity3.88400020
4MP0003698_abnormal_male_reproductive3.57551393
5MP0008877_abnormal_DNA_methylation3.22666928
6MP0009046_muscle_twitch3.17875174
7MP0001929_abnormal_gametogenesis2.99992443
8MP0003635_abnormal_synaptic_transmissio2.94440400
9MP0001968_abnormal_touch/_nociception2.57236154
10MP0009745_abnormal_behavioral_response2.55384603
11MP0004270_analgesia2.40761986
12MP0002249_abnormal_larynx_morphology2.37677583
13MP0002064_seizures2.30881783
14MP0002063_abnormal_learning/memory/cond2.26962101
15MP0002736_abnormal_nociception_after2.20541406
16MP0002735_abnormal_chemical_nociception2.19182242
17MP0001984_abnormal_olfaction2.17454218
18MP0002272_abnormal_nervous_system2.14528244
19MP0002572_abnormal_emotion/affect_behav2.13557198
20MP0010030_abnormal_orbit_morphology2.03205455
21MP0002210_abnormal_sex_determination1.99305915
22MP0006276_abnormal_autonomic_nervous1.94655831
23MP0002653_abnormal_ependyma_morphology1.92851436
24MP0002234_abnormal_pharynx_morphology1.91603019
25MP0002161_abnormal_fertility/fecundity1.87943569
26MP0005423_abnormal_somatic_nervous1.86802239
27MP0001486_abnormal_startle_reflex1.86746123
28MP0002822_catalepsy1.83685285
29MP0002734_abnormal_mechanical_nocicepti1.82091718
30MP0001440_abnormal_grooming_behavior1.72205011
31MP0002067_abnormal_sensory_capabilities1.68097573
32MP0003123_paternal_imprinting1.66876829
33MP0001145_abnormal_male_reproductive1.64181342
34MP0008569_lethality_at_weaning1.60266248
35MP0002733_abnormal_thermal_nociception1.59873139
36MP0001501_abnormal_sleep_pattern1.57589019
37MP0005645_abnormal_hypothalamus_physiol1.55038736
38MP0003122_maternal_imprinting1.51861931
39MP0002160_abnormal_reproductive_system1.50665551
40MP0002909_abnormal_adrenal_gland1.50532535
41MP0002557_abnormal_social/conspecific_i1.49820418
42MP0003329_amyloid_beta_deposits1.43946090
43MP0000653_abnormal_sex_gland1.42041357
44MP0001970_abnormal_pain_threshold1.41244985
45MP0004811_abnormal_neuron_physiology1.40543304
46MP0000566_synostosis1.40026399
47MP0001529_abnormal_vocalization1.39470429
48MP0003787_abnormal_imprinting1.37295339
49MP0002184_abnormal_innervation1.32703577
50MP0001188_hyperpigmentation1.30229164
51MP0004142_abnormal_muscle_tone1.28147272
52MP0001905_abnormal_dopamine_level1.26458603
53MP0005386_behavior/neurological_phenoty1.22931800
54MP0004924_abnormal_behavior1.22931800
55MP0005646_abnormal_pituitary_gland1.22709714
56MP0009278_abnormal_bone_marrow1.21017183
57MP0001346_abnormal_lacrimal_gland1.20168781
58MP0000049_abnormal_middle_ear1.19514381
59MP0001986_abnormal_taste_sensitivity1.18676481
60MP0000955_abnormal_spinal_cord1.18610490
61MP0000678_abnormal_parathyroid_gland1.17060438
62MP0003879_abnormal_hair_cell1.15186503
63MP0001502_abnormal_circadian_rhythm1.13986456
64MP0004858_abnormal_nervous_system1.13419753
65MP0000681_abnormal_thyroid_gland1.09048124
66MP0002066_abnormal_motor_capabilities/c1.06890638
67MP0002882_abnormal_neuron_morphology1.06149686
68MP0000778_abnormal_nervous_system1.05356853
69MP0003633_abnormal_nervous_system1.05277229
70MP0003646_muscle_fatigue1.05144383
71MP0000751_myopathy1.02635305
72MP0004145_abnormal_muscle_electrophysio0.99328423
73MP0005670_abnormal_white_adipose0.94824165
74MP0005551_abnormal_eye_electrophysiolog0.92998439
75MP0000631_abnormal_neuroendocrine_gland0.92170925
76MP0003942_abnormal_urinary_system0.91992176
77MP0002152_abnormal_brain_morphology0.91726310
78MP0003631_nervous_system_phenotype0.91613150
79MP0004233_abnormal_muscle_weight0.91295243
80MP0003183_abnormal_peptide_metabolism0.90160851
81MP0000026_abnormal_inner_ear0.88622488
82MP0002089_abnormal_postnatal_growth/wei0.88379275
83MP0000003_abnormal_adipose_tissue0.87623660
84MP0002229_neurodegeneration0.87584878
85MP0008872_abnormal_physiological_respon0.84077163
86MP0003690_abnormal_glial_cell0.83849217
87MP0003137_abnormal_impulse_conducting0.83551596
88MP0000534_abnormal_ureter_morphology0.82320170
89MP0009379_abnormal_foot_pigmentation0.81861760
90MP0000639_abnormal_adrenal_gland0.81430139
91MP0006292_abnormal_olfactory_placode0.80193632
92MP0003861_abnormal_nervous_system0.80007437
93MP0004133_heterotaxia0.79989529
94MP0004742_abnormal_vestibular_system0.79467847
95MP0001765_abnormal_ion_homeostasis0.75011679
96MP0003938_abnormal_ear_development0.74625487
97MP0001963_abnormal_hearing_physiology0.73653268
98MP0008874_decreased_physiological_sensi0.70483109
99MP0008260_abnormal_autophagy0.70393711
100MP0000920_abnormal_myelination0.70130956
101MP0000013_abnormal_adipose_tissue0.69368803
102MP0006072_abnormal_retinal_apoptosis0.69140298
103MP0008789_abnormal_olfactory_epithelium0.68800459
104MP0005389_reproductive_system_phenotype0.68692988
105MP0005623_abnormal_meninges_morphology0.66325053
106MP0005167_abnormal_blood-brain_barrier0.66193172
107MP0005394_taste/olfaction_phenotype0.65432594
108MP0005499_abnormal_olfactory_system0.65432594
109MP0003385_abnormal_body_wall0.65160739
110MP0002752_abnormal_somatic_nervous0.65135622
111MP0002837_dystrophic_cardiac_calcinosis0.64558296
112MP0001849_ear_inflammation0.63707570
113MP0002932_abnormal_joint_morphology0.63122200
114MP0003121_genomic_imprinting0.62934690
115MP0004085_abnormal_heartbeat0.62886181
116MP0000015_abnormal_ear_pigmentation0.61962779
117MP0002069_abnormal_eating/drinking_beha0.61319407
118MP0008995_early_reproductive_senescence0.60833205
119MP0002638_abnormal_pupillary_reflex0.60523263
120MP0003172_abnormal_lysosome_physiology0.59225222
121MP0005535_abnormal_body_temperature0.58908666
122MP0004885_abnormal_endolymph0.58141839
123MP0010769_abnormal_survival0.57919234
124MP0009780_abnormal_chondrocyte_physiolo0.55460862
125MP0006035_abnormal_mitochondrial_morpho0.55332866
126MP0000569_abnormal_digit_pigmentation0.55049695
127MP0000604_amyloidosis0.54729666
128MP0003632_abnormal_nervous_system0.52924477
129MP0005253_abnormal_eye_physiology0.50257356
130MP0003634_abnormal_glial_cell0.50079370
131MP0001664_abnormal_digestion0.49231283

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.66337635
2Absent/shortened dynein arms (HP:0200106)9.66337635
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.24558715
4Abnormal respiratory motile cilium physiology (HP:0012261)7.09197250
5Abnormal respiratory epithelium morphology (HP:0012253)6.93181343
6Abnormal respiratory motile cilium morphology (HP:0005938)6.93181343
7Rhinitis (HP:0012384)6.12429940
8Abnormal ciliary motility (HP:0012262)5.93912608
9Infertility (HP:0000789)5.11137477
10Chronic bronchitis (HP:0004469)4.76527601
11Focal motor seizures (HP:0011153)4.24354240
12Nephronophthisis (HP:0000090)4.05364709
13Nasal polyposis (HP:0100582)4.00554022
14Limb dystonia (HP:0002451)3.88821658
15Medial flaring of the eyebrow (HP:0010747)3.49749355
16Abnormality of the nasal mucosa (HP:0000433)3.22856149
17Bronchiectasis (HP:0002110)3.18881416
18Gonadotropin excess (HP:0000837)3.11054275
19Hyperthyroidism (HP:0000836)3.10113513
20Abnormality of the lower motor neuron (HP:0002366)3.09372703
21Abnormality of the renal medulla (HP:0100957)3.04102925
22Epileptic encephalopathy (HP:0200134)3.02763088
23Myokymia (HP:0002411)3.02496997
24Congenital malformation of the right heart (HP:0011723)3.00151373
25Double outlet right ventricle (HP:0001719)3.00151373
26Annular pancreas (HP:0001734)2.99752285
27Bronchitis (HP:0012387)2.92244426
28Amblyopia (HP:0000646)2.90328628
29Akinesia (HP:0002304)2.89037651
30Progressive cerebellar ataxia (HP:0002073)2.88349747
31Action tremor (HP:0002345)2.88012699
32Focal seizures (HP:0007359)2.86275005
33Insomnia (HP:0100785)2.83120718
34Torticollis (HP:0000473)2.81638210
35Focal dystonia (HP:0004373)2.79390588
36Visual hallucinations (HP:0002367)2.77925123
37Gait imbalance (HP:0002141)2.69858682
38Atonic seizures (HP:0010819)2.68969275
39Truncus arteriosus (HP:0001660)2.67789980
40Abnormality of the aortic arch (HP:0012303)2.66495022
41Obstructive sleep apnea (HP:0002870)2.65122243
42Abnormality of midbrain morphology (HP:0002418)2.62657794
43Molar tooth sign on MRI (HP:0002419)2.62657794
44Gaze-evoked nystagmus (HP:0000640)2.60560648
45Congenital primary aphakia (HP:0007707)2.58461493
46Broad distal phalanx of finger (HP:0009836)2.55993031
47Retinal dysplasia (HP:0007973)2.55151260
48Craniofacial dystonia (HP:0012179)2.54581521
49Tubulointerstitial nephritis (HP:0001970)2.53933298
50Hyperacusis (HP:0010780)2.53111292
51Febrile seizures (HP:0002373)2.48193460
52Cerebral hypomyelination (HP:0006808)2.46767657
53Turricephaly (HP:0000262)2.41739358
54Amyotrophic lateral sclerosis (HP:0007354)2.40309355
55Nephrogenic diabetes insipidus (HP:0009806)2.37823909
56Abnormality of binocular vision (HP:0011514)2.35783115
57Diplopia (HP:0000651)2.35783115
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.34307720
59Hypoplastic left heart (HP:0004383)2.33761962
60Bronchomalacia (HP:0002780)2.30787865
61Sleep apnea (HP:0010535)2.25850498
62Abnormality of ocular smooth pursuit (HP:0000617)2.20836795
63Type II lissencephaly (HP:0007260)2.19741375
64Overriding aorta (HP:0002623)2.17507540
65Genital tract atresia (HP:0001827)2.15046069
66Atelectasis (HP:0100750)2.14882734
67Progressive inability to walk (HP:0002505)2.13406643
68Vaginal atresia (HP:0000148)2.13394496
69Spastic gait (HP:0002064)2.09936400
70Hemiparesis (HP:0001269)2.09493110
71Rigidity (HP:0002063)2.07907730
72Recurrent otitis media (HP:0000403)2.06997912
73Hypoplastic heart (HP:0001961)2.05987086
74Tubular atrophy (HP:0000092)2.05216091
75Hyperventilation (HP:0002883)2.03790306
76Transposition of the great arteries (HP:0001669)2.01534103
77Abnormal connection of the cardiac segments (HP:0011545)2.01534103
78Abnormal ventriculo-arterial connection (HP:0011563)2.01534103
79Pointed chin (HP:0000307)2.01195577
80Poor eye contact (HP:0000817)1.99872581
81Aplasia/Hypoplasia of the lens (HP:0008063)1.99584006
82Neuronal loss in central nervous system (HP:0002529)1.98861966
83Recurrent sinusitis (HP:0011108)1.98605269
84Impaired vibration sensation in the lower limbs (HP:0002166)1.98502229
85Supranuclear gaze palsy (HP:0000605)1.97111209
86Spinal canal stenosis (HP:0003416)1.94507874
87J-shaped sella turcica (HP:0002680)1.93722460
88Truncal ataxia (HP:0002078)1.93349094
89Rapidly progressive (HP:0003678)1.91835792
90Peripheral hypomyelination (HP:0007182)1.91725049
91Male infertility (HP:0003251)1.90950533
92Tubulointerstitial abnormality (HP:0001969)1.90824513
93Testicular atrophy (HP:0000029)1.90822657
94Status epilepticus (HP:0002133)1.89744519
95Fibular hypoplasia (HP:0003038)1.89380773
96Stridor (HP:0010307)1.88270173
97Myotonia (HP:0002486)1.87134207
98Postaxial hand polydactyly (HP:0001162)1.86982359
99Impaired smooth pursuit (HP:0007772)1.86958353
100Renal duplication (HP:0000075)1.86932676
101Abnormal spermatogenesis (HP:0008669)1.86322406
102Dysmetria (HP:0001310)1.84985427
103Elfin facies (HP:0004428)1.83694716
104Hand muscle atrophy (HP:0009130)1.83457877
105Poor coordination (HP:0002370)1.83375412
106Distal upper limb amyotrophy (HP:0007149)1.81861777
107Upper limb amyotrophy (HP:0009129)1.81861777
108Partial duplication of thumb phalanx (HP:0009944)1.80962777
109Absence seizures (HP:0002121)1.80183190
110Fetal akinesia sequence (HP:0001989)1.78019525
111Infantile muscular hypotonia (HP:0008947)1.77921705
112Lower limb asymmetry (HP:0100559)1.76482426
113Papilledema (HP:0001085)1.75441735
114Postaxial foot polydactyly (HP:0001830)1.75212772
115Lissencephaly (HP:0001339)1.74834096
116Split foot (HP:0001839)1.73068101
117Aplasia of the phalanges of the hand (HP:0009802)1.72938215
118Aplasia involving bones of the extremities (HP:0009825)1.72938215
119Aplasia involving bones of the upper limbs (HP:0009823)1.72938215
120Partial duplication of the phalanx of hand (HP:0009999)1.72241614
121Ankle clonus (HP:0011448)1.71506259
122Growth hormone excess (HP:0000845)1.70312833
123Muscle stiffness (HP:0003552)1.69774695
124Recurrent bronchitis (HP:0002837)1.69388976
125Diminished movement (HP:0002374)1.68694231
126Hypercortisolism (HP:0001578)1.68509767
127Renal dysplasia (HP:0000110)1.67530988
128Failure to thrive in infancy (HP:0001531)1.67397503
129Supernumerary spleens (HP:0009799)1.67016988
130Polyphagia (HP:0002591)1.66935761
131Postural instability (HP:0002172)1.66877809
132Inability to walk (HP:0002540)1.66537966
133Shallow orbits (HP:0000586)1.66075328
134Epileptiform EEG discharges (HP:0011182)1.64949658
135Impaired vibratory sensation (HP:0002495)1.64848119
136Depression (HP:0000716)1.64688223
137Alacrima (HP:0000522)1.64518523
138Renovascular hypertension (HP:0100817)1.64489842
139Limb ataxia (HP:0002070)1.64158351
140Megalencephaly (HP:0001355)1.63985643
141Tetraplegia (HP:0002445)1.63881460
142Anxiety (HP:0000739)1.63832349
143Dialeptic seizures (HP:0011146)1.63368045
144Impaired social interactions (HP:0000735)1.61817657
145Abnormal social behavior (HP:0012433)1.61817657
146Abnormality of the diencephalon (HP:0010662)1.61495091
147Aplasia/Hypoplasia of the brainstem (HP:0007362)1.60083357
148Hypoplasia of the brainstem (HP:0002365)1.60083357
149Neurofibrillary tangles (HP:0002185)1.59930929
150Bradykinesia (HP:0002067)1.59608045
151Abnormality of permanent molar morphology (HP:0011071)1.59370743
152Abnormality of the dental root (HP:0006486)1.59370743
153Taurodontia (HP:0000679)1.59370743
154Abnormal drinking behavior (HP:0030082)1.59354540
155Polydipsia (HP:0001959)1.59354540
156Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.59310240
157Degeneration of the lateral corticospinal tracts (HP:0002314)1.58505986
158Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.58505986
159Aggressive behavior (HP:0000718)1.58262510
160Abnormal gallbladder physiology (HP:0012438)1.57299281
161Cholecystitis (HP:0001082)1.57299281
162Abnormality of saccadic eye movements (HP:0000570)1.56858359
163Oculomotor apraxia (HP:0000657)1.56713962
164Specific learning disability (HP:0001328)1.55546698
165Acute necrotizing encephalopathy (HP:0006965)1.54506029
166Choroideremia (HP:0001139)1.54171011
167Abnormal hair whorl (HP:0010721)1.53672994
168Median cleft lip (HP:0000161)1.53209734
169Congenital hepatic fibrosis (HP:0002612)1.53004290
170Delusions (HP:0000746)1.52933222
171Abnormal eating behavior (HP:0100738)1.52652702
172Stage 5 chronic kidney disease (HP:0003774)1.51858030
173Generalized tonic-clonic seizures (HP:0002069)1.50216455
174Cerebral inclusion bodies (HP:0100314)1.49767045
175Impaired proprioception (HP:0010831)1.49257564
176Optic disc pallor (HP:0000543)1.47652358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.04656679
2PDK46.04656679
3TESK13.69629530
4PRKD33.67147483
5PDK23.55988836
6NTRK33.02132411
7PNCK2.58005470
8CASK2.52314928
9MAP2K72.41721938
10TRIB32.35286077
11MAP3K112.31358826
12PTK2B2.27304559
13MAP3K42.24109210
14BCKDK2.18307978
15MAP3K92.13535932
16EPHA42.12488022
17ICK2.05007586
18VRK22.01718184
19TNIK1.90435890
20WNK41.86992630
21MAP3K121.84769260
22MUSK1.78394387
23NTRK21.71784096
24MINK11.63629571
25SMG11.63193065
26STK391.57599485
27STK381.56844461
28RIPK41.54825427
29AKT31.42881176
30MAP2K41.33501331
31CSNK1G31.22584350
32SIK21.22282350
33CSNK1G21.19903007
34CDK191.19170882
35LIMK11.13755304
36MARK11.12548918
37DYRK21.11911288
38NME21.10024522
39CCNB11.06999931
40DAPK11.04726031
41RIPK11.02275556
42WNK11.01857166
43PIM21.00253950
44SIK11.00008577
45PLK20.99834293
46DYRK1B0.99067395
47PRKCG0.97502006
48SGK20.97169816
49DAPK20.96794298
50MAPK130.95349332
51ERN10.95231140
52GRK50.94216412
53CAMKK10.92868761
54DAPK30.92750786
55PKN10.91699532
56BRSK10.88952801
57MAPK120.88872358
58PAK60.88863357
59PDK10.87173417
60TYRO30.86140294
61LMTK20.84642062
62TESK20.83038872
63EPHB20.82440370
64ABL20.81687126
65PINK10.80231624
66SGK4940.79459001
67SGK2230.79459001
68CDK50.78025057
69PRKCH0.77251657
70CAMKK20.76893830
71CSNK1A1L0.76442606
72NTRK10.75105353
73BRAF0.74732572
74MAPK150.74597280
75CAMK10.72817056
76LATS20.71161012
77CSNK1G10.67639334
78RPS6KA20.67048807
79CAMK2A0.67010711
80SRPK10.66250051
81ARAF0.64782961
82PRKD20.61919839
83SGK30.61725998
84UHMK10.60635778
85NEK20.60532697
86STK110.60035719
87KSR20.58764394
88FES0.54893997
89MAP2K60.53925342
90TNK20.53896173
91ROCK20.53340462
92TAOK20.52381509
93MAP2K20.51841964
94CAMK1G0.48462339
95PRKD10.48386853
96PRKCZ0.47910217
97MOS0.47614996
98NEK60.47562921
99GRK70.47502315
100MAPK40.46956867
101CDK180.46950479
102KDR0.46796991
103IRAK20.45961907
104PHKG20.45392405
105PHKG10.45392405
106MARK20.45087138
107AURKA0.44867999
108CDK150.44510174
109PDPK10.44475576
110PKN20.43656214
111ACVR1B0.41786809
112BMPR20.41102336
113CDK30.41018468
114ADRBK20.40266666
115MYLK0.40082897
116CDK11A0.38842363
117CDK140.38774130
118KSR10.38210326
119PASK0.37862943
120ILK0.37812524
121HIPK20.37767491
122BMPR1B0.36817542
123MAPK80.36304656
124WNK30.35732722
125MAPKAPK50.34810077
126CAMK2B0.31372545
127ADRBK10.30066856
128MAP3K10.29640541
129OXSR10.29293610
130DYRK1A0.28247949
131RPS6KB10.25661619
132PRPF4B0.25376103
133SGK10.22235332
134MAPK100.22230722
135PRKCE0.21873571
136IRAK10.21838331
137PRKACA0.21829908
138CAMK2G0.20683305
139RPS6KA30.19427736
140MAP3K20.18901646
141GRK60.18878981
142PRKG10.18093592
143PRKCB0.17694051
144CAMK2D0.17597215

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.61569397
2Synaptic vesicle cycle_Homo sapiens_hsa047213.35413927
3Amphetamine addiction_Homo sapiens_hsa050312.83664770
4Long-term potentiation_Homo sapiens_hsa047202.76838089
5Sulfur relay system_Homo sapiens_hsa041222.73178091
6Circadian entrainment_Homo sapiens_hsa047132.42847811
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35578987
8Olfactory transduction_Homo sapiens_hsa047402.26398315
9Collecting duct acid secretion_Homo sapiens_hsa049662.22657828
10Glutamatergic synapse_Homo sapiens_hsa047242.16843561
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16081398
12Morphine addiction_Homo sapiens_hsa050322.13976405
13Taste transduction_Homo sapiens_hsa047422.09980184
14GABAergic synapse_Homo sapiens_hsa047272.06850962
15Cardiac muscle contraction_Homo sapiens_hsa042602.05499080
16Insulin secretion_Homo sapiens_hsa049111.99837508
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.96246870
18Renin secretion_Homo sapiens_hsa049241.95613665
19Dopaminergic synapse_Homo sapiens_hsa047281.92175611
20Huntingtons disease_Homo sapiens_hsa050161.84389304
21Oxidative phosphorylation_Homo sapiens_hsa001901.83638387
22Salivary secretion_Homo sapiens_hsa049701.80740826
23Calcium signaling pathway_Homo sapiens_hsa040201.73142051
24Glucagon signaling pathway_Homo sapiens_hsa049221.72874076
25Pyruvate metabolism_Homo sapiens_hsa006201.62493452
26Gastric acid secretion_Homo sapiens_hsa049711.61920221
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59461494
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57150250
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.53444573
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46585278
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46397166
32Serotonergic synapse_Homo sapiens_hsa047261.45592067
33Oocyte meiosis_Homo sapiens_hsa041141.44418009
34Cocaine addiction_Homo sapiens_hsa050301.43216447
35Parkinsons disease_Homo sapiens_hsa050121.41546922
36Alzheimers disease_Homo sapiens_hsa050101.40067133
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38230615
38Cholinergic synapse_Homo sapiens_hsa047251.36739392
39Biosynthesis of amino acids_Homo sapiens_hsa012301.36533736
40Oxytocin signaling pathway_Homo sapiens_hsa049211.35426410
41Notch signaling pathway_Homo sapiens_hsa043301.32307494
42Dorso-ventral axis formation_Homo sapiens_hsa043201.25781466
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.23476490
44Vibrio cholerae infection_Homo sapiens_hsa051101.23283280
45Long-term depression_Homo sapiens_hsa047301.23276019
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22513625
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.20110416
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18348194
49Estrogen signaling pathway_Homo sapiens_hsa049151.15827953
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12711667
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12591350
52Phenylalanine metabolism_Homo sapiens_hsa003601.12158400
53cAMP signaling pathway_Homo sapiens_hsa040241.11391879
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10371036
55Arginine and proline metabolism_Homo sapiens_hsa003301.10165432
56Prion diseases_Homo sapiens_hsa050201.09779737
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09718408
58Folate biosynthesis_Homo sapiens_hsa007901.09706218
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08733389
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07917534
61Fatty acid biosynthesis_Homo sapiens_hsa000611.05368517
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03326434
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01273144
64cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00331456
65Arginine biosynthesis_Homo sapiens_hsa002200.98134128
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97343216
67Carbon metabolism_Homo sapiens_hsa012000.94870160
68Alcoholism_Homo sapiens_hsa050340.94205525
69Bile secretion_Homo sapiens_hsa049760.90238348
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.88699923
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85096802
72Basal transcription factors_Homo sapiens_hsa030220.84215621
73Vitamin B6 metabolism_Homo sapiens_hsa007500.81214537
74GnRH signaling pathway_Homo sapiens_hsa049120.78759215
75Melanogenesis_Homo sapiens_hsa049160.78476699
76Ribosome_Homo sapiens_hsa030100.78369679
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77990221
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77451067
79Gap junction_Homo sapiens_hsa045400.77283389
80Tyrosine metabolism_Homo sapiens_hsa003500.74036945
81Thyroid hormone synthesis_Homo sapiens_hsa049180.73423474
82Basal cell carcinoma_Homo sapiens_hsa052170.72178668
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71123712
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70252219
85Pancreatic secretion_Homo sapiens_hsa049720.62270487
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62183319
87Type II diabetes mellitus_Homo sapiens_hsa049300.60862362
88Phototransduction_Homo sapiens_hsa047440.60568333
89Axon guidance_Homo sapiens_hsa043600.60246057
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59471316
91Base excision repair_Homo sapiens_hsa034100.57716025
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.55906672
93AMPK signaling pathway_Homo sapiens_hsa041520.55723788
94N-Glycan biosynthesis_Homo sapiens_hsa005100.55071799
95Inositol phosphate metabolism_Homo sapiens_hsa005620.55007582
96Hedgehog signaling pathway_Homo sapiens_hsa043400.54445537
97VEGF signaling pathway_Homo sapiens_hsa043700.54222607
98Fructose and mannose metabolism_Homo sapiens_hsa000510.53452313
99Fatty acid metabolism_Homo sapiens_hsa012120.51723385
100beta-Alanine metabolism_Homo sapiens_hsa004100.51173489
101MAPK signaling pathway_Homo sapiens_hsa040100.50956016
102Wnt signaling pathway_Homo sapiens_hsa043100.50641917
103Galactose metabolism_Homo sapiens_hsa000520.50549432
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49684150
105Glioma_Homo sapiens_hsa052140.49409042
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48413837
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48281584
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45594038
109Hippo signaling pathway_Homo sapiens_hsa043900.44913905
110Peroxisome_Homo sapiens_hsa041460.44540801
111Glycerolipid metabolism_Homo sapiens_hsa005610.43603402
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43329495
113Butanoate metabolism_Homo sapiens_hsa006500.43145595
114Dilated cardiomyopathy_Homo sapiens_hsa054140.42387635
115ErbB signaling pathway_Homo sapiens_hsa040120.42255790
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41788910
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41681229
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41247518
119Propanoate metabolism_Homo sapiens_hsa006400.40333605
120Purine metabolism_Homo sapiens_hsa002300.39768550
121Type I diabetes mellitus_Homo sapiens_hsa049400.39430399
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.39352900
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.38889095
124Endocytosis_Homo sapiens_hsa041440.38608659
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38585721
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34798236
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34431368
128Linoleic acid metabolism_Homo sapiens_hsa005910.32954395
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31516282
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30932598
131Rheumatoid arthritis_Homo sapiens_hsa053230.30785209
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.30357008
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29719029
134Circadian rhythm_Homo sapiens_hsa047100.28007936
135Pentose phosphate pathway_Homo sapiens_hsa000300.27754867
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26762897
137Ether lipid metabolism_Homo sapiens_hsa005650.26682435

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