TCEAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.02711330
2presynaptic membrane assembly (GO:0097105)4.66468459
3presynaptic membrane organization (GO:0097090)4.38572749
4synaptic vesicle exocytosis (GO:0016079)4.30774017
5protein complex biogenesis (GO:0070271)4.30399620
6vocalization behavior (GO:0071625)4.26403329
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.15663748
8water-soluble vitamin biosynthetic process (GO:0042364)4.01101742
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.91606968
10protein localization to synapse (GO:0035418)3.91559901
11mitochondrial respiratory chain complex assembly (GO:0033108)3.89110440
12neuronal action potential propagation (GO:0019227)3.87462545
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.86962493
14energy coupled proton transport, down electrochemical gradient (GO:0015985)3.73919571
15ATP synthesis coupled proton transport (GO:0015986)3.73919571
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.68669906
17axon ensheathment in central nervous system (GO:0032291)3.64259180
18central nervous system myelination (GO:0022010)3.64259180
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.62086532
20regulation of synaptic vesicle exocytosis (GO:2000300)3.61636382
21gamma-aminobutyric acid signaling pathway (GO:0007214)3.60247634
22postsynaptic membrane organization (GO:0001941)3.55975405
23negative regulation of synaptic transmission, GABAergic (GO:0032229)3.52533404
24neuron recognition (GO:0008038)3.52317175
25platelet dense granule organization (GO:0060155)3.50934466
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.45871722
27regulation of glutamate receptor signaling pathway (GO:1900449)3.45705031
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.44501410
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41419694
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.41419694
31NADH dehydrogenase complex assembly (GO:0010257)3.41419694
32positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.41332771
33glutamate secretion (GO:0014047)3.39862440
34neuron-neuron synaptic transmission (GO:0007270)3.37107664
35cytochrome complex assembly (GO:0017004)3.36808388
36regulation of mitochondrial translation (GO:0070129)3.36592190
37xenobiotic catabolic process (GO:0042178)3.32818230
38respiratory electron transport chain (GO:0022904)3.32135408
39glutamate receptor signaling pathway (GO:0007215)3.30877488
40negative regulation of neurotransmitter transport (GO:0051589)3.29848129
41respiratory chain complex IV assembly (GO:0008535)3.29295744
42positive regulation of synapse assembly (GO:0051965)3.29246009
43electron transport chain (GO:0022900)3.25992196
44neurotransmitter-gated ion channel clustering (GO:0072578)3.25535247
45ATP hydrolysis coupled proton transport (GO:0015991)3.23888779
46energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.23888779
47inositol phosphate catabolic process (GO:0071545)3.22712255
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.22670044
49transmission of nerve impulse (GO:0019226)3.21075175
50long-term synaptic potentiation (GO:0060291)3.20264709
51proteasome assembly (GO:0043248)3.20223897
52aggressive behavior (GO:0002118)3.20007504
53chaperone-mediated protein transport (GO:0072321)3.19456621
54negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18910667
55mannosylation (GO:0097502)3.18861246
56synaptic transmission, glutamatergic (GO:0035249)3.17906452
57neurotransmitter secretion (GO:0007269)3.16795484
58relaxation of smooth muscle (GO:0044557)3.16029533
59positive regulation of actin filament depolymerization (GO:0030836)3.14311853
60response to nitrosative stress (GO:0051409)3.10597505
61regulation of synaptic vesicle transport (GO:1902803)3.06739690
62inositol phosphate dephosphorylation (GO:0046855)3.00781030
63phosphorylated carbohydrate dephosphorylation (GO:0046838)3.00781030
64regulation of vesicle fusion (GO:0031338)2.99133260
65neurotransmitter transport (GO:0006836)2.98862104
66neurotransmitter uptake (GO:0001504)2.98823928
67detection of calcium ion (GO:0005513)2.97755188
68regulation of catecholamine metabolic process (GO:0042069)2.97387324
69regulation of dopamine metabolic process (GO:0042053)2.97387324
70startle response (GO:0001964)2.96622160
71axonal fasciculation (GO:0007413)2.94601623
72long-chain fatty acid biosynthetic process (GO:0042759)2.90552373
73locomotory exploration behavior (GO:0035641)2.89175598
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89028131
75negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.88629209
76detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88456515
77ubiquinone biosynthetic process (GO:0006744)2.85012709
78response to histamine (GO:0034776)2.83615511
79transferrin transport (GO:0033572)2.82712138
80dopamine biosynthetic process (GO:0042416)2.81596901
81positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80294610
82protein localization to cilium (GO:0061512)2.79804737
83regulation of cilium movement (GO:0003352)2.79532702
84regulation of excitatory postsynaptic membrane potential (GO:0060079)2.79272915
85intraciliary transport (GO:0042073)2.78919859
86regulation of synaptic transmission, glutamatergic (GO:0051966)2.78040628
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.76002972
88GTP biosynthetic process (GO:0006183)2.75690682
89positive regulation of neurotransmitter secretion (GO:0001956)2.75337027
90synapse assembly (GO:0007416)2.74478956
91establishment of protein localization to mitochondrial membrane (GO:0090151)2.71612805
92calcium-mediated signaling using intracellular calcium source (GO:0035584)2.71224367
93regulation of postsynaptic membrane potential (GO:0060078)2.70718142
94cerebellar granule cell differentiation (GO:0021707)2.70311117
95gamma-aminobutyric acid transport (GO:0015812)2.70153382
96response to cocaine (GO:0042220)2.68587797
97synaptic vesicle maturation (GO:0016188)2.68496302
98exploration behavior (GO:0035640)2.68226773
99dopamine transport (GO:0015872)2.67499082
100regulation of glutamate secretion (GO:0014048)2.67485972
101positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.66962842
102trivalent inorganic cation transport (GO:0072512)2.66482445
103ferric iron transport (GO:0015682)2.66482445
104regulation of neuronal synaptic plasticity (GO:0048168)2.66423491
105regulation of neurotransmitter levels (GO:0001505)2.66043892
106regulation of synapse assembly (GO:0051963)2.65853071
107aldehyde catabolic process (GO:0046185)2.65815924
108amino acid salvage (GO:0043102)2.65302895
109L-methionine salvage (GO:0071267)2.65302895
110L-methionine biosynthetic process (GO:0071265)2.65302895
111positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.63642756
112dendrite development (GO:0016358)2.62379332
113positive regulation of action potential (GO:0045760)2.61756545
114positive regulation of membrane potential (GO:0045838)2.61384844
115cilium movement (GO:0003341)2.61020310
116axoneme assembly (GO:0035082)2.60574573
117cullin deneddylation (GO:0010388)2.60094979
118regulation of neurotransmitter secretion (GO:0046928)2.59954448
119long-term memory (GO:0007616)2.59617176
120dendritic spine morphogenesis (GO:0060997)2.59501521
121behavioral response to nicotine (GO:0035095)2.59077301
122protein neddylation (GO:0045116)2.58757267
123mechanosensory behavior (GO:0007638)2.58465985
124C-terminal protein lipidation (GO:0006501)2.58447520
125regulation of hexokinase activity (GO:1903299)2.58411432
126regulation of glucokinase activity (GO:0033131)2.58411432
127positive regulation of amino acid transport (GO:0051957)2.58224523
128regulation of protein kinase A signaling (GO:0010738)2.56760600
129G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56099655
130regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.56036214
131membrane assembly (GO:0071709)2.55175488
132regulation of long-term neuronal synaptic plasticity (GO:0048169)2.55074170
133retinal cone cell development (GO:0046549)2.54359704
134opioid receptor signaling pathway (GO:0038003)2.54338299
135membrane hyperpolarization (GO:0060081)2.54137972
136ubiquinone metabolic process (GO:0006743)2.53816386
137GPI anchor biosynthetic process (GO:0006506)2.53351198
138positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.53007132
139synaptic vesicle endocytosis (GO:0048488)2.52735221
140adult walking behavior (GO:0007628)2.51948825
141parental behavior (GO:0060746)2.51662380
142GPI anchor metabolic process (GO:0006505)2.50454814
143mating behavior (GO:0007617)2.50418513
144regulation of synaptic transmission, GABAergic (GO:0032228)2.49587076
145branched-chain amino acid catabolic process (GO:0009083)2.49123899
146anterograde synaptic vesicle transport (GO:0048490)2.46151703
147preassembly of GPI anchor in ER membrane (GO:0016254)2.45534915
148hydrogen ion transmembrane transport (GO:1902600)2.44941208
149protein deneddylation (GO:0000338)2.44312101
150anterograde axon cargo transport (GO:0008089)2.41267780
151nonmotile primary cilium assembly (GO:0035058)2.40416985
152C-terminal protein amino acid modification (GO:0018410)2.40161407
153positive regulation of neurotransmitter transport (GO:0051590)2.38918656
154behavioral response to ethanol (GO:0048149)2.36334648
155auditory receptor cell stereocilium organization (GO:0060088)2.34554806
156glycolipid biosynthetic process (GO:0009247)2.33876088
157hydrogen transport (GO:0006818)2.33709572
158protein polyglutamylation (GO:0018095)2.32368366
159glutathione derivative metabolic process (GO:1901685)2.30674581
160glutathione derivative biosynthetic process (GO:1901687)2.30674581
161proton transport (GO:0015992)2.30609955
162positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.30058401
163positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.28801454
164protein-cofactor linkage (GO:0018065)2.28342789
165polyol catabolic process (GO:0046174)2.27435594
166cornea development in camera-type eye (GO:0061303)2.26351079
167inner ear receptor stereocilium organization (GO:0060122)2.25484266
168response to gravity (GO:0009629)2.22625575
169regulation of microtubule-based movement (GO:0060632)2.22117687
170lactate metabolic process (GO:0006089)2.22026504
171lipid particle organization (GO:0034389)2.20251662
172nitric oxide mediated signal transduction (GO:0007263)2.20223978
173lipopolysaccharide biosynthetic process (GO:0009103)2.18671505
174positive regulation of protein autophosphorylation (GO:0031954)2.18395813
175S-adenosylmethionine metabolic process (GO:0046500)2.17669171
176negative regulation of calcium ion transmembrane transport (GO:1903170)2.16974965
177negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.16974965

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.96315196
2GBX2_23144817_ChIP-Seq_PC3_Human3.90177033
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.22444986
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.11969988
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98066458
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86341557
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80069757
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75898706
9TAF15_26573619_Chip-Seq_HEK293_Human2.71029169
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.49473913
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42325424
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39752357
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37529553
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35298834
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33581879
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.31659500
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29529654
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28419930
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.26944580
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26123254
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26123254
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22103538
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21298794
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17590084
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14488159
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13673276
27* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13190850
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12149160
29REST_21632747_ChIP-Seq_MESCs_Mouse2.10784080
30EST1_17652178_ChIP-ChIP_JURKAT_Human2.09956913
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99877423
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.98352366
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95664297
34* P300_19829295_ChIP-Seq_ESCs_Human1.95512863
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93388070
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.91501935
37VDR_22108803_ChIP-Seq_LS180_Human1.90804418
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90362848
39AR_21572438_ChIP-Seq_LNCaP_Human1.84798941
40FUS_26573619_Chip-Seq_HEK293_Human1.80080305
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.78280156
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74523106
43SMAD4_21799915_ChIP-Seq_A2780_Human1.73750706
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.73328393
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68579082
46IGF1R_20145208_ChIP-Seq_DFB_Human1.68508580
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68061241
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.67009686
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.61193439
50ELK1_19687146_ChIP-ChIP_HELA_Human1.59401823
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58299278
52* RNF2_27304074_Chip-Seq_NSC_Mouse1.58137367
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.51456148
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50505411
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50350889
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.48520436
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47551811
58ZNF274_21170338_ChIP-Seq_K562_Hela1.46935783
59ER_23166858_ChIP-Seq_MCF-7_Human1.46903837
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44008085
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43544864
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41346542
63DROSHA_22980978_ChIP-Seq_HELA_Human1.40842543
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38602766
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.34122513
66AR_25329375_ChIP-Seq_VCAP_Human1.30314494
67TP53_22573176_ChIP-Seq_HFKS_Human1.28338835
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27658470
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27410441
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.27287139
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25314574
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24599415
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.24579788
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23775550
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23575843
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23477036
77NANOG_19829295_ChIP-Seq_ESCs_Human1.21680446
78SOX2_19829295_ChIP-Seq_ESCs_Human1.21680446
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21629347
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18922601
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.18899666
82VDR_23849224_ChIP-Seq_CD4+_Human1.18889680
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18022552
84MYC_18940864_ChIP-ChIP_HL60_Human1.17978996
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.16128602
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15855838
87STAT3_23295773_ChIP-Seq_U87_Human1.14813936
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14100182
89RUNX2_22187159_ChIP-Seq_PCA_Human1.13141625
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12518052
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09886551
92TCF4_23295773_ChIP-Seq_U87_Human1.09616444
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09109654
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09099804
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08709822
96TCF4_22108803_ChIP-Seq_LS180_Human1.07977737
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07961029
98JUN_21703547_ChIP-Seq_K562_Human1.06940834
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06708988
100HTT_18923047_ChIP-ChIP_STHdh_Human1.06681707
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06493649
102EWS_26573619_Chip-Seq_HEK293_Human1.06424135
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.06378751
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06322183
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.05748689
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.04785997
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03409559
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.03371701
109TRIM28_21343339_ChIP-Seq_HEK293_Human1.02811172
110P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01701996
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00306741
112PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00287318
113NCOR_22424771_ChIP-Seq_293T_Human0.99346299
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98984131
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98984131
116EZH2_27294783_Chip-Seq_NPCs_Mouse0.98922657
117PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98525731
118* SMAD4_21741376_ChIP-Seq_EPCs_Human0.98158392
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97992104
120AR_20517297_ChIP-Seq_VCAP_Human0.97967844
121RING1B_27294783_Chip-Seq_ESCs_Mouse0.97649312
122TP53_18474530_ChIP-ChIP_U2OS_Human0.97560516
123BCAT_22108803_ChIP-Seq_LS180_Human0.97449721
124P53_22387025_ChIP-Seq_ESCs_Mouse0.96163851
125CDX2_22108803_ChIP-Seq_LS180_Human0.96072544
126KDM2B_26808549_Chip-Seq_REH_Human0.95942858
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95333006
128E2F1_18555785_Chip-Seq_ESCs_Mouse0.95145657
129CMYC_18555785_Chip-Seq_ESCs_Mouse0.94477297
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93972917
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93637220
132TAL1_26923725_Chip-Seq_HPCs_Mouse0.93350492
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93226579
134CBP_20019798_ChIP-Seq_JUKART_Human0.93096807
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93096807
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91457442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.48259947
2MP0004859_abnormal_synaptic_plasticity3.42565034
3MP0003635_abnormal_synaptic_transmissio3.04771050
4MP0009745_abnormal_behavioral_response2.85981769
5MP0002064_seizures2.80564184
6MP0001968_abnormal_touch/_nociception2.79770462
7MP0004270_analgesia2.75402122
8MP0009046_muscle_twitch2.74586553
9MP0002272_abnormal_nervous_system2.54118429
10MP0006276_abnormal_autonomic_nervous2.50516224
11MP0002736_abnormal_nociception_after2.47157877
12MP0002572_abnormal_emotion/affect_behav2.46499263
13MP0002063_abnormal_learning/memory/cond2.43618715
14MP0002734_abnormal_mechanical_nocicepti2.40352782
15MP0001529_abnormal_vocalization2.38194162
16MP0003122_maternal_imprinting2.34521745
17MP0005423_abnormal_somatic_nervous2.27455576
18MP0001905_abnormal_dopamine_level2.23561516
19MP0005646_abnormal_pituitary_gland2.20406484
20MP0002735_abnormal_chemical_nociception2.18928091
21MP0001486_abnormal_startle_reflex2.18889480
22MP0001501_abnormal_sleep_pattern2.10456494
23MP0001440_abnormal_grooming_behavior2.04023596
24MP0005645_abnormal_hypothalamus_physiol2.03444627
25MP0001188_hyperpigmentation2.00142219
26MP0000372_irregular_coat_pigmentation1.99913897
27MP0002067_abnormal_sensory_capabilities1.95215662
28MP0001970_abnormal_pain_threshold1.92618563
29MP0002733_abnormal_thermal_nociception1.92477110
30MP0004142_abnormal_muscle_tone1.88319456
31MP0005084_abnormal_gallbladder_morpholo1.87361126
32MP0001984_abnormal_olfaction1.82921229
33MP0002160_abnormal_reproductive_system1.81307360
34MP0000778_abnormal_nervous_system1.78496198
35MP0003283_abnormal_digestive_organ1.71479248
36MP0002557_abnormal_social/conspecific_i1.67771228
37MP0004147_increased_porphyrin_level1.66862892
38MP0002184_abnormal_innervation1.66671611
39MP0006036_abnormal_mitochondrial_physio1.65233535
40MP0010386_abnormal_urinary_bladder1.60801874
41MP0002837_dystrophic_cardiac_calcinosis1.59847314
42MP0003136_yellow_coat_color1.56836596
43MP0009780_abnormal_chondrocyte_physiolo1.56024481
44MP0003195_calcinosis1.55560231
45MP0000427_abnormal_hair_cycle1.55010910
46MP0002638_abnormal_pupillary_reflex1.54915318
47MP0004742_abnormal_vestibular_system1.53136126
48MP0002102_abnormal_ear_morphology1.51731712
49MP0006072_abnormal_retinal_apoptosis1.51618922
50MP0005551_abnormal_eye_electrophysiolog1.51226495
51MP0002822_catalepsy1.50721259
52MP0005386_behavior/neurological_phenoty1.49488876
53MP0004924_abnormal_behavior1.49488876
54MP0000013_abnormal_adipose_tissue1.49000306
55MP0008877_abnormal_DNA_methylation1.47145465
56MP0001502_abnormal_circadian_rhythm1.46831209
57MP0008569_lethality_at_weaning1.38841813
58MP0005409_darkened_coat_color1.37551655
59MP0000749_muscle_degeneration1.36755153
60MP0001986_abnormal_taste_sensitivity1.35363781
61MP0008875_abnormal_xenobiotic_pharmacok1.32781702
62MP0002882_abnormal_neuron_morphology1.31990638
63MP0002234_abnormal_pharynx_morphology1.31868657
64MP0005171_absent_coat_pigmentation1.29225243
65MP0005379_endocrine/exocrine_gland_phen1.28907366
66MP0000631_abnormal_neuroendocrine_gland1.28040594
67MP0004043_abnormal_pH_regulation1.27561306
68MP0000955_abnormal_spinal_cord1.27280741
69MP0003787_abnormal_imprinting1.27206483
70MP0002938_white_spotting1.25932584
71MP0002876_abnormal_thyroid_physiology1.25675392
72MP0002066_abnormal_motor_capabilities/c1.23973197
73MP0000516_abnormal_urinary_system1.23374023
74MP0005367_renal/urinary_system_phenotyp1.23374023
75MP0003186_abnormal_redox_activity1.22161895
76MP0004885_abnormal_endolymph1.21270480
77MP0009697_abnormal_copulation1.19586115
78MP0002229_neurodegeneration1.13971493
79MP0009379_abnormal_foot_pigmentation1.12518040
80MP0001963_abnormal_hearing_physiology1.12373047
81MP0005389_reproductive_system_phenotype1.11127979
82MP0004811_abnormal_neuron_physiology1.09804683
83MP0004145_abnormal_muscle_electrophysio1.09707314
84MP0005187_abnormal_penis_morphology1.08009507
85MP0000639_abnormal_adrenal_gland1.07413410
86MP0005332_abnormal_amino_acid1.06049781
87MP0000920_abnormal_myelination1.05907062
88MP0003879_abnormal_hair_cell1.05623915
89MP0003329_amyloid_beta_deposits1.04646410
90MP0002282_abnormal_trachea_morphology1.04178354
91MP0006035_abnormal_mitochondrial_morpho1.02339223
92MP0005253_abnormal_eye_physiology1.00895746
93MP0003634_abnormal_glial_cell1.00793980
94MP0003633_abnormal_nervous_system1.00209051
95MP0002752_abnormal_somatic_nervous0.99959218
96MP0001756_abnormal_urination0.98016410
97MP0001485_abnormal_pinna_reflex0.97728213
98MP0002909_abnormal_adrenal_gland0.97516694
99MP0008775_abnormal_heart_ventricle0.97494195
100MP0005394_taste/olfaction_phenotype0.94627035
101MP0005499_abnormal_olfactory_system0.94627035
102MP0001764_abnormal_homeostasis0.94290147
103MP0003631_nervous_system_phenotype0.91705383
104MP0003011_delayed_dark_adaptation0.91020246
105MP0002152_abnormal_brain_morphology0.90894104
106MP0000026_abnormal_inner_ear0.90872526
107MP0005220_abnormal_exocrine_pancreas0.89473075
108MP0000751_myopathy0.88962514
109MP0003690_abnormal_glial_cell0.88333887
110MP0002090_abnormal_vision0.88316483
111MP0003121_genomic_imprinting0.88240010
112MP0002163_abnormal_gland_morphology0.87992817
113MP0001944_abnormal_pancreas_morphology0.87216616
114MP0001664_abnormal_digestion0.85147662
115MP0003183_abnormal_peptide_metabolism0.84362515
116MP0006292_abnormal_olfactory_placode0.82703221
117MP0008058_abnormal_DNA_repair0.80373431
118MP0002069_abnormal_eating/drinking_beha0.79366930
119MP0004858_abnormal_nervous_system0.77752480
120MP0000647_abnormal_sebaceous_gland0.77264773
121MP0002751_abnormal_autonomic_nervous0.76923131
122MP0004085_abnormal_heartbeat0.75681209
123MP0008872_abnormal_physiological_respon0.74316689
124MP0010329_abnormal_lipoprotein_level0.73910605
125MP0008789_abnormal_olfactory_epithelium0.73863409
126MP0000230_abnormal_systemic_arterial0.71823882
127MP0005620_abnormal_muscle_contractility0.71231016
128MP0000015_abnormal_ear_pigmentation0.69725156
129MP0003632_abnormal_nervous_system0.69660541
130MP0004484_altered_response_of0.69556856
131MP0005535_abnormal_body_temperature0.69555180
132MP0001177_atelectasis0.65620008
133MP0005195_abnormal_posterior_eye0.63923750
134MP0002653_abnormal_ependyma_morphology0.60471622
135MP0004215_abnormal_myocardial_fiber0.60385020
136MP0001943_abnormal_respiration0.60238044
137MP0000538_abnormal_urinary_bladder0.58077679

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.40240549
2Acute necrotizing encephalopathy (HP:0006965)4.45776630
3Atonic seizures (HP:0010819)4.42941760
4Abnormal mitochondria in muscle tissue (HP:0008316)4.02003182
5Progressive macrocephaly (HP:0004481)3.98680901
6Epileptic encephalopathy (HP:0200134)3.84872169
7Abnormal ciliary motility (HP:0012262)3.83089473
8Myokymia (HP:0002411)3.77625980
9Hyperventilation (HP:0002883)3.72442482
10Focal seizures (HP:0007359)3.60247556
11Gait imbalance (HP:0002141)3.48049075
12Abnormal respiratory motile cilium physiology (HP:0012261)3.42560449
13Acute encephalopathy (HP:0006846)3.42398687
14Mitochondrial inheritance (HP:0001427)3.41119248
15Febrile seizures (HP:0002373)3.35210548
16Medial flaring of the eyebrow (HP:0010747)3.32605806
17Absence seizures (HP:0002121)3.26745117
18Limb dystonia (HP:0002451)3.26526641
19Congenital primary aphakia (HP:0007707)3.25262476
20Hypothermia (HP:0002045)3.14718055
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.11176730
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.11176730
23Dialeptic seizures (HP:0011146)3.09892792
24Abnormal respiratory motile cilium morphology (HP:0005938)3.04840164
25Abnormal respiratory epithelium morphology (HP:0012253)3.04840164
26Pheochromocytoma (HP:0002666)3.04675634
27Nephrogenic diabetes insipidus (HP:0009806)3.03809521
28Visual hallucinations (HP:0002367)2.98189113
29Metaphyseal dysplasia (HP:0100255)2.93468633
30Neuroendocrine neoplasm (HP:0100634)2.87357338
31Genital tract atresia (HP:0001827)2.87225092
32Methylmalonic acidemia (HP:0002912)2.83509808
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.81259551
34Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.81259551
35Pancreatic cysts (HP:0001737)2.80829733
36Optic disc pallor (HP:0000543)2.80725332
37Vaginal atresia (HP:0000148)2.80623264
38Progressive cerebellar ataxia (HP:0002073)2.79231171
39Retinal dysplasia (HP:0007973)2.78379714
40Increased CSF lactate (HP:0002490)2.75431267
41Abnormal hair whorl (HP:0010721)2.71055167
42Broad-based gait (HP:0002136)2.70148306
43Generalized tonic-clonic seizures (HP:0002069)2.69120165
44Absent/shortened dynein arms (HP:0200106)2.67353157
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.67353157
46Delayed gross motor development (HP:0002194)2.60249864
47Large for gestational age (HP:0001520)2.56646792
48Rhinitis (HP:0012384)2.54594100
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54510084
50Hepatocellular necrosis (HP:0001404)2.50005208
51Anxiety (HP:0000739)2.48956066
52Ketoacidosis (HP:0001993)2.46565819
53Leukodystrophy (HP:0002415)2.43524525
54Progressive inability to walk (HP:0002505)2.42112959
55Polyphagia (HP:0002591)2.41126662
56Specific learning disability (HP:0001328)2.37150996
57Hypoglycemic coma (HP:0001325)2.36137969
58Muscle hypertrophy of the lower extremities (HP:0008968)2.35721320
59Nephronophthisis (HP:0000090)2.31019375
60Neurofibrillary tangles (HP:0002185)2.29594661
61Abnormality of the corticospinal tract (HP:0002492)2.27626446
62Methylmalonic aciduria (HP:0012120)2.27608582
63Amblyopia (HP:0000646)2.21910258
64Poor coordination (HP:0002370)2.21783449
65Pancreatic fibrosis (HP:0100732)2.21201580
66Ketosis (HP:0001946)2.20875270
67Lactic acidosis (HP:0003128)2.20660993
68Esotropia (HP:0000565)2.18914306
69Failure to thrive in infancy (HP:0001531)2.18756855
70Hemiparesis (HP:0001269)2.17959090
71Abnormal eating behavior (HP:0100738)2.16018772
723-Methylglutaconic aciduria (HP:0003535)2.15262302
73Poor suck (HP:0002033)2.14872671
74Aplasia/Hypoplasia of the lens (HP:0008063)2.14290953
75Sensory axonal neuropathy (HP:0003390)2.12998463
76Epileptiform EEG discharges (HP:0011182)2.12819263
77Truncal ataxia (HP:0002078)2.11474376
78Hypoglycemic seizures (HP:0002173)2.10984020
79True hermaphroditism (HP:0010459)2.09964985
80Hyperinsulinemic hypoglycemia (HP:0000825)2.08907474
81Short tibia (HP:0005736)2.08748839
82Excessive salivation (HP:0003781)2.06451633
83Drooling (HP:0002307)2.06451633
84Renal cortical cysts (HP:0000803)2.06019332
85Increased serum lactate (HP:0002151)2.05770431
86Increased hepatocellular lipid droplets (HP:0006565)2.05718993
87Type I transferrin isoform profile (HP:0003642)2.05250069
88Calf muscle hypertrophy (HP:0008981)2.04643097
89Scanning speech (HP:0002168)2.04291519
90Abnormality of the renal medulla (HP:0100957)2.04215991
91EEG with generalized epileptiform discharges (HP:0011198)2.03734689
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01929941
93Abnormal protein N-linked glycosylation (HP:0012347)2.01929941
94Abnormal protein glycosylation (HP:0012346)2.01929941
95Abnormal glycosylation (HP:0012345)2.01929941
96Abnormality of the renal cortex (HP:0011035)2.01549140
97Hyperglycinemia (HP:0002154)2.01265405
98X-linked dominant inheritance (HP:0001423)2.00964379
99Gaze-evoked nystagmus (HP:0000640)2.00143091
100Agitation (HP:0000713)1.98247612
101Abnormality of vitamin B metabolism (HP:0004340)1.97590059
102Opisthotonus (HP:0002179)1.95449870
103Cerebral edema (HP:0002181)1.95205726
104Hypokinesia (HP:0002375)1.94467074
105Absent speech (HP:0001344)1.94326152
106Renal Fanconi syndrome (HP:0001994)1.93123473
107Cerebral inclusion bodies (HP:0100314)1.92448188
108CNS demyelination (HP:0007305)1.91907504
109Dysmetria (HP:0001310)1.91887654
110Diminished movement (HP:0002374)1.91236598
111Lethargy (HP:0001254)1.91038999
112Hyperglycemia (HP:0003074)1.90916915
113Molar tooth sign on MRI (HP:0002419)1.89665328
114Abnormality of midbrain morphology (HP:0002418)1.89665328
115Supranuclear gaze palsy (HP:0000605)1.88655358
116Exercise intolerance (HP:0003546)1.88243453
117Constricted visual fields (HP:0001133)1.87971103
118Hyperthyroidism (HP:0000836)1.87829841
119Type II lissencephaly (HP:0007260)1.87738691
120Hypsarrhythmia (HP:0002521)1.87286345
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.86731394
122Lipid accumulation in hepatocytes (HP:0006561)1.86570947
123Atrophy/Degeneration involving motor neurons (HP:0007373)1.86185588
124Muscular hypotonia of the trunk (HP:0008936)1.85079320
125Aplasia/Hypoplasia of the tibia (HP:0005772)1.85053527
126Dysdiadochokinesis (HP:0002075)1.84076488
127Symptomatic seizures (HP:0011145)1.83893425
128Progressive microcephaly (HP:0000253)1.83844666
129Abnormal pupillary function (HP:0007686)1.82916789
130Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82852706
131Increased serum pyruvate (HP:0003542)1.82596155
132Abnormality of glycolysis (HP:0004366)1.82596155
133Generalized myoclonic seizures (HP:0002123)1.82108833
134Termporal pattern (HP:0011008)1.82016949
135Insidious onset (HP:0003587)1.82016949
136Increased intramyocellular lipid droplets (HP:0012240)1.81700489
137Delusions (HP:0000746)1.81036032
138Blue irides (HP:0000635)1.80965580
139Reduced antithrombin III activity (HP:0001976)1.80589667
140Inability to walk (HP:0002540)1.79508766
141Respiratory failure (HP:0002878)1.79329938
142Amyotrophic lateral sclerosis (HP:0007354)1.79189656
143Action tremor (HP:0002345)1.78819352
144Thickened helices (HP:0000391)1.78367083
145Psychosis (HP:0000709)1.75439986
146Abnormal drinking behavior (HP:0030082)1.74930922
147Polydipsia (HP:0001959)1.74930922
148Depression (HP:0000716)1.73928771
149Glycosuria (HP:0003076)1.71500299
150Abnormality of urine glucose concentration (HP:0011016)1.71500299
151CNS hypomyelination (HP:0003429)1.71064471
152Hepatic necrosis (HP:0002605)1.70289405
153Narrow nasal bridge (HP:0000446)1.67862377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.97105435
2NTRK33.27592968
3MAP3K122.79357719
4MAP3K42.57270811
5MAP4K22.56856254
6MAP2K72.44036562
7BCKDK2.40573073
8PNCK2.32038107
9MARK12.21935688
10EIF2AK32.18261318
11EPHA42.07227839
12TNIK2.04427056
13OXSR12.03769708
14GRK51.86032588
15CDK191.84446726
16NME11.84372599
17STK391.78308601
18PINK11.76744556
19GRK71.72200888
20MINK11.69308907
21MAPK131.69220813
22NTRK21.68948452
23NUAK11.64663287
24PRPF4B1.63129268
25PLK21.60469008
26TRIM281.58055867
27MAP3K91.55182545
28ARAF1.54679693
29BMPR1B1.54190343
30UHMK11.53277802
31GRK11.53159972
32MAPK151.53044409
33VRK21.44592504
34MAPKAPK51.42271914
35MAP2K41.38194735
36CAMK2B1.37150814
37BCR1.35400045
38CAMK2A1.30689862
39AKT31.29186028
40ADRBK21.28936430
41FES1.27805813
42TESK11.24845385
43NTRK11.23337094
44BMPR21.22299708
45OBSCN1.19136676
46WNK41.16268285
47MUSK1.14966101
48STK161.13957505
49TRPM71.12786923
50CAMK2D1.10592380
51SGK2231.09003999
52SGK4941.09003999
53CDK51.07443579
54WNK31.03975010
55MAP3K21.03305445
56PRKCI1.03062770
57MAPKAPK31.02676724
58PRKCE1.01595376
59PHKG21.00550359
60PHKG11.00550359
61PRKCG0.96906756
62EIF2AK10.94817967
63DAPK20.94510870
64STK38L0.93331723
65PAK30.93172324
66TNK20.91216074
67PAK60.90610499
68CAMKK20.88293019
69ABL20.86593936
70ADRBK10.86484920
71CSNK1G20.86347500
72MYLK0.86345557
73PKN10.86285157
74CSNK1G30.83872665
75CAMK2G0.83612551
76NEK60.78952573
77INSRR0.78466440
78DYRK1A0.74017798
79KSR20.73423468
80IRAK20.73001441
81FGR0.71869920
82VRK10.70970436
83LIMK10.70149675
84CDK140.69993206
85FER0.69921126
86TSSK60.68357803
87FGFR20.66561982
88PRKD30.65828030
89CDK180.65213222
90ILK0.64300593
91PTK2B0.61388726
92CDK150.60853783
93FRK0.60621322
94MKNK20.60258420
95CDK30.60216562
96MST40.59463448
97PLK30.59150908
98WNK10.58466082
99KSR10.58213523
100ROCK20.57931747
101PRKACA0.57887909
102BRAF0.56547307
103SGK20.54459060
104PDK20.54289663
105DAPK10.53871085
106CDK11A0.52705158
107ERBB30.52580530
108CSNK1G10.52221248
109TIE10.51261005
110CAMK10.47733398
111TLK10.47615084
112CSNK1A1L0.46954387
113PIK3CA0.46953797
114MARK20.46276921
115PIM20.46275938
116BRSK20.46091376
117MAP2K10.45831204
118DYRK20.44992286
119SIK30.44689842
120PRKG10.44651171
121RIPK40.44541674
122CSNK1A10.43818394
123PRKD10.43513134
124AKT20.42318228
125ZAK0.42129416
126RPS6KA50.41556637
127PRKCH0.40697988
128CCNB10.40087864
129ABL10.40022143
130SGK10.39984500
131PTK20.39834516
132KIT0.39386470
133PBK0.39218366
134IRAK10.38099059
135CDK80.36894967
136ROCK10.35014278
137* PRKCA0.31904416

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.84098961
2Nicotine addiction_Homo sapiens_hsa050333.78058005
3Synaptic vesicle cycle_Homo sapiens_hsa047213.09276964
4Parkinsons disease_Homo sapiens_hsa050123.02504488
5Collecting duct acid secretion_Homo sapiens_hsa049662.94445642
6GABAergic synapse_Homo sapiens_hsa047272.59833774
7Alzheimers disease_Homo sapiens_hsa050102.55775271
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55466311
9Morphine addiction_Homo sapiens_hsa050322.19841641
10Huntingtons disease_Homo sapiens_hsa050162.09799849
11Propanoate metabolism_Homo sapiens_hsa006402.09648908
12Vibrio cholerae infection_Homo sapiens_hsa051102.06577690
13Serotonergic synapse_Homo sapiens_hsa047262.06344730
14Glutamatergic synapse_Homo sapiens_hsa047242.05884636
15Circadian entrainment_Homo sapiens_hsa047132.04710665
16Taste transduction_Homo sapiens_hsa047422.01213677
17Amphetamine addiction_Homo sapiens_hsa050311.98112897
18Cardiac muscle contraction_Homo sapiens_hsa042601.87391536
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86536706
20Protein export_Homo sapiens_hsa030601.83866982
21Dopaminergic synapse_Homo sapiens_hsa047281.80240972
22Insulin secretion_Homo sapiens_hsa049111.79580115
23Olfactory transduction_Homo sapiens_hsa047401.72495209
24Cocaine addiction_Homo sapiens_hsa050301.68351274
25Long-term depression_Homo sapiens_hsa047301.67442601
26Long-term potentiation_Homo sapiens_hsa047201.66778553
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60517071
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59012285
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54933560
30Salivary secretion_Homo sapiens_hsa049701.50988596
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50923578
32Renin secretion_Homo sapiens_hsa049241.49839855
33Peroxisome_Homo sapiens_hsa041461.48163546
34Cholinergic synapse_Homo sapiens_hsa047251.43604085
35RNA polymerase_Homo sapiens_hsa030201.42538257
36Phototransduction_Homo sapiens_hsa047441.42467272
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.31976680
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31933561
39Gastric acid secretion_Homo sapiens_hsa049711.28763735
40Calcium signaling pathway_Homo sapiens_hsa040201.21815690
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20971332
42Glutathione metabolism_Homo sapiens_hsa004801.20510346
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19351756
44Vitamin B6 metabolism_Homo sapiens_hsa007501.16304917
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16285400
46Folate biosynthesis_Homo sapiens_hsa007901.15604900
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15160143
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14452508
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09874098
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07513337
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07144804
52Rheumatoid arthritis_Homo sapiens_hsa053231.06874160
53Fatty acid elongation_Homo sapiens_hsa000621.05837363
54Tryptophan metabolism_Homo sapiens_hsa003801.05282359
55Sulfur relay system_Homo sapiens_hsa041221.02615504
56Oxytocin signaling pathway_Homo sapiens_hsa049211.01567733
57Axon guidance_Homo sapiens_hsa043601.00547518
58Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00128085
59Nitrogen metabolism_Homo sapiens_hsa009100.98565149
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97758943
61Gap junction_Homo sapiens_hsa045400.95841715
62Selenocompound metabolism_Homo sapiens_hsa004500.95003433
63beta-Alanine metabolism_Homo sapiens_hsa004100.94266035
64Chemical carcinogenesis_Homo sapiens_hsa052040.94217271
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92606162
66Mineral absorption_Homo sapiens_hsa049780.91477957
67Ether lipid metabolism_Homo sapiens_hsa005650.88597872
68Sulfur metabolism_Homo sapiens_hsa009200.86625080
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85568536
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.85521638
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84104231
72Fatty acid metabolism_Homo sapiens_hsa012120.82881536
73Purine metabolism_Homo sapiens_hsa002300.80803365
74GnRH signaling pathway_Homo sapiens_hsa049120.80610720
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80165963
76Pyrimidine metabolism_Homo sapiens_hsa002400.79187415
77Fatty acid degradation_Homo sapiens_hsa000710.76602237
78Butanoate metabolism_Homo sapiens_hsa006500.75770482
79Type I diabetes mellitus_Homo sapiens_hsa049400.75332277
80Arginine and proline metabolism_Homo sapiens_hsa003300.74245458
81cAMP signaling pathway_Homo sapiens_hsa040240.74167868
82Basal transcription factors_Homo sapiens_hsa030220.71623592
83Pancreatic secretion_Homo sapiens_hsa049720.70974082
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.70446968
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69672147
86Melanogenesis_Homo sapiens_hsa049160.68425207
87Sphingolipid metabolism_Homo sapiens_hsa006000.67255418
88Phagosome_Homo sapiens_hsa041450.66364965
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66016781
90Fanconi anemia pathway_Homo sapiens_hsa034600.63230696
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.61354030
92Homologous recombination_Homo sapiens_hsa034400.60041102
93Estrogen signaling pathway_Homo sapiens_hsa049150.59870295
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.58934183
95Linoleic acid metabolism_Homo sapiens_hsa005910.58540808
96N-Glycan biosynthesis_Homo sapiens_hsa005100.57536626
97Alcoholism_Homo sapiens_hsa050340.56810841
98RNA degradation_Homo sapiens_hsa030180.55917762
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55326808
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52958484
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52063702
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50231271
103Ras signaling pathway_Homo sapiens_hsa040140.47033898
104Thyroid hormone synthesis_Homo sapiens_hsa049180.46513336
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46106716
106ErbB signaling pathway_Homo sapiens_hsa040120.45996797
107Arachidonic acid metabolism_Homo sapiens_hsa005900.45847839
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45551613
109Circadian rhythm_Homo sapiens_hsa047100.45382310
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45156876
111Dilated cardiomyopathy_Homo sapiens_hsa054140.42791890
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42212015
113Type II diabetes mellitus_Homo sapiens_hsa049300.41320542
114One carbon pool by folate_Homo sapiens_hsa006700.40833816
115Tyrosine metabolism_Homo sapiens_hsa003500.40769992
116Regulation of autophagy_Homo sapiens_hsa041400.40015151
117Non-homologous end-joining_Homo sapiens_hsa034500.39149818
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38749454
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36773829
120Dorso-ventral axis formation_Homo sapiens_hsa043200.35292971
121Ovarian steroidogenesis_Homo sapiens_hsa049130.35230500
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35226117
123MAPK signaling pathway_Homo sapiens_hsa040100.35207796
124Prion diseases_Homo sapiens_hsa050200.33399330
125Steroid biosynthesis_Homo sapiens_hsa001000.30725153
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.30608418
127Pyruvate metabolism_Homo sapiens_hsa006200.30605412
128African trypanosomiasis_Homo sapiens_hsa051430.30342613
129Renal cell carcinoma_Homo sapiens_hsa052110.30241542
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30096876
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29677176
132Choline metabolism in cancer_Homo sapiens_hsa052310.28554298
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26145793
134Glioma_Homo sapiens_hsa052140.26098433
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.25822484
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24096021
137Metabolic pathways_Homo sapiens_hsa011000.24076022
138Melanoma_Homo sapiens_hsa052180.24064801
139Proteasome_Homo sapiens_hsa030500.23651715
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22179870

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