TCEAL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.11989399
2synaptic vesicle maturation (GO:0016188)5.95560517
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.55379833
4synaptic vesicle exocytosis (GO:0016079)5.52194144
5locomotory exploration behavior (GO:0035641)5.27883339
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.19780818
7vocalization behavior (GO:0071625)5.08818869
8regulation of synaptic vesicle exocytosis (GO:2000300)5.05566440
9glutamate secretion (GO:0014047)5.02488274
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.92241826
11neuronal action potential propagation (GO:0019227)4.81849670
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.72808180
13regulation of glutamate receptor signaling pathway (GO:1900449)4.66894246
14protein localization to synapse (GO:0035418)4.60592014
15regulation of synaptic vesicle transport (GO:1902803)4.53505369
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.44913651
17neurotransmitter secretion (GO:0007269)4.43726287
18regulation of neuronal synaptic plasticity (GO:0048168)4.32439697
19exploration behavior (GO:0035640)4.20894495
20neuron cell-cell adhesion (GO:0007158)4.12602276
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.10601898
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.08319652
23synaptic transmission, glutamatergic (GO:0035249)4.04461689
24glutamate receptor signaling pathway (GO:0007215)3.93777902
25positive regulation of synaptic transmission, GABAergic (GO:0032230)3.91161329
26regulation of synapse structural plasticity (GO:0051823)3.87186594
27neuron-neuron synaptic transmission (GO:0007270)3.84212179
28proline transport (GO:0015824)3.80077848
29neuromuscular process controlling posture (GO:0050884)3.73939138
30long-term memory (GO:0007616)3.73218925
31gamma-aminobutyric acid transport (GO:0015812)3.71790023
32dendritic spine morphogenesis (GO:0060997)3.70027028
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.69847757
34positive regulation of membrane potential (GO:0045838)3.68872625
35neurotransmitter-gated ion channel clustering (GO:0072578)3.68202684
36cellular potassium ion homeostasis (GO:0030007)3.67155376
37neurotransmitter transport (GO:0006836)3.65200506
38layer formation in cerebral cortex (GO:0021819)3.61546360
39activation of protein kinase A activity (GO:0034199)3.60697174
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59787031
41cerebellar Purkinje cell differentiation (GO:0021702)3.45020551
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44074064
43regulation of vesicle fusion (GO:0031338)3.43572394
44regulation of postsynaptic membrane potential (GO:0060078)3.43076107
45regulation of synaptic plasticity (GO:0048167)3.42729848
46regulation of neurotransmitter secretion (GO:0046928)3.41865598
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.41613806
48synaptic vesicle endocytosis (GO:0048488)3.39227341
49long-term synaptic potentiation (GO:0060291)3.38199259
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.36682524
51sodium ion export (GO:0071436)3.35254842
52regulation of neurotransmitter levels (GO:0001505)3.34258399
53transmission of nerve impulse (GO:0019226)3.33791627
54neuron recognition (GO:0008038)3.28813293
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.28422868
56neuromuscular process controlling balance (GO:0050885)3.26546831
57innervation (GO:0060384)3.22171794
58cell communication by electrical coupling (GO:0010644)3.19631750
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.18985256
60response to gravity (GO:0009629)3.18864021
61negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18727836
62membrane depolarization during action potential (GO:0086010)3.18654495
63regulation of neurotransmitter transport (GO:0051588)3.17557640
64postsynaptic membrane organization (GO:0001941)3.15350556
65axon ensheathment in central nervous system (GO:0032291)3.13947644
66central nervous system myelination (GO:0022010)3.13947644
67regulation of dendritic spine morphogenesis (GO:0061001)3.12557604
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.12436496
69vesicle transport along microtubule (GO:0047496)3.12369386
70negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12006490
71behavioral defense response (GO:0002209)3.11253915
72behavioral fear response (GO:0001662)3.11253915
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.10954674
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10048087
75positive regulation of synapse maturation (GO:0090129)3.10028730
76presynaptic membrane assembly (GO:0097105)3.09783807
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.08877383
78glycine transport (GO:0015816)3.08277461
79membrane hyperpolarization (GO:0060081)3.06793962
80membrane depolarization (GO:0051899)3.06684932
81response to auditory stimulus (GO:0010996)3.05939787
82positive regulation of synaptic transmission (GO:0050806)3.03669283
83presynaptic membrane organization (GO:0097090)3.02891837
84neuronal ion channel clustering (GO:0045161)3.02748603
85synaptic transmission (GO:0007268)3.01226870
86positive regulation of synapse assembly (GO:0051965)2.99765674
87prepulse inhibition (GO:0060134)2.99462603
88detection of calcium ion (GO:0005513)2.99335795
89regulation of synaptic transmission (GO:0050804)2.97769711
90fear response (GO:0042596)2.97254767
91positive regulation of neurotransmitter transport (GO:0051590)2.95010500
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94876759
93axonal fasciculation (GO:0007413)2.93400257
94auditory behavior (GO:0031223)2.93385119
95neuromuscular process (GO:0050905)2.92071802
96learning (GO:0007612)2.91270352
97regulation of synaptic transmission, GABAergic (GO:0032228)2.89390446
98dendrite morphogenesis (GO:0048813)2.89188055
99establishment of mitochondrion localization (GO:0051654)2.88850857
100cerebellar Purkinje cell layer development (GO:0021680)2.87782670
101startle response (GO:0001964)2.87520442
102chemosensory behavior (GO:0007635)2.87162203
103potassium ion homeostasis (GO:0055075)2.86769305
104synapse assembly (GO:0007416)2.86133503
105striatum development (GO:0021756)2.85525188
106G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85172369
107positive regulation of neurotransmitter secretion (GO:0001956)2.85020259
108calcium ion-dependent exocytosis (GO:0017156)2.84769494
109axon extension (GO:0048675)2.84603658
110pyrimidine nucleobase catabolic process (GO:0006208)2.79525559
111cell migration in hindbrain (GO:0021535)2.76999200
112regulation of respiratory system process (GO:0044065)2.73357868
113astrocyte development (GO:0014002)2.71451312
114cerebellar granule cell differentiation (GO:0021707)2.69653868
115astrocyte differentiation (GO:0048708)2.61747884
116neuromuscular synaptic transmission (GO:0007274)2.60151342
117regulation of neurotransmitter uptake (GO:0051580)2.59519757
118dendritic spine organization (GO:0097061)2.56663135
119adult walking behavior (GO:0007628)2.56309164
120protein heterotrimerization (GO:0070208)2.54308034
121synapse organization (GO:0050808)2.52374256
122negative regulation of axon extension (GO:0030517)2.50342509
123potassium ion import (GO:0010107)2.42758186
124positive regulation of dendritic spine development (GO:0060999)2.42650999
125neuron projection extension (GO:1990138)2.41367333
126negative regulation of axonogenesis (GO:0050771)2.40326963
127mating behavior (GO:0007617)2.38931441
128nonmotile primary cilium assembly (GO:0035058)2.38579261
129suckling behavior (GO:0001967)2.37191782
130behavioral response to cocaine (GO:0048148)2.37069552
131adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.36054869
132urinary tract smooth muscle contraction (GO:0014848)2.36019100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.07836748
2GBX2_23144817_ChIP-Seq_PC3_Human3.34116476
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25575623
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.22344592
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16277275
6REST_21632747_ChIP-Seq_MESCs_Mouse2.89249587
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.86130352
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81872476
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81872476
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71544725
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.69636069
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.67879629
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65841382
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.64318745
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.62502181
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.61889070
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.41898891
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.41205216
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.40894245
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40336046
21DROSHA_22980978_ChIP-Seq_HELA_Human2.36988327
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.28311594
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.22115171
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21233320
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15358845
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13051268
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95820594
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76782154
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75038241
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71889097
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.66425120
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65507232
33TAF15_26573619_Chip-Seq_HEK293_Human1.64219104
34SMAD4_21799915_ChIP-Seq_A2780_Human1.59727739
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57203423
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52181594
37AR_21572438_ChIP-Seq_LNCaP_Human1.48661701
38ZNF274_21170338_ChIP-Seq_K562_Hela1.44594204
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43434757
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.42503395
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40685203
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37829876
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35822145
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35821716
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.34512845
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33371501
47P300_19829295_ChIP-Seq_ESCs_Human1.30998312
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29750462
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29565003
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.25917014
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25866069
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25376723
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24865151
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24682520
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.24370155
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24002743
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22872768
58AR_25329375_ChIP-Seq_VCAP_Human1.21508022
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.17004241
60IGF1R_20145208_ChIP-Seq_DFB_Human1.16992894
61STAT3_23295773_ChIP-Seq_U87_Human1.15366172
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15287324
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14958636
64AR_19668381_ChIP-Seq_PC3_Human1.14916570
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.13655725
66RNF2_27304074_Chip-Seq_NSC_Mouse1.13066923
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12822442
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.12287637
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10542268
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10292263
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08121372
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.07748748
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07354282
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06631357
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00463155
76ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99889481
77P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99660478
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99598105
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99068406
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98255555
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97991828
82KDM2B_26808549_Chip-Seq_K562_Human0.97529450
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97298120
84SMAD3_21741376_ChIP-Seq_ESCs_Human0.97279072
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96611978
86TCF4_23295773_ChIP-Seq_U87_Human0.96596106
87YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96512598
88RUNX2_22187159_ChIP-Seq_PCA_Human0.93871741
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93093317
90CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92637375
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.90943046
92CTCF_27219007_Chip-Seq_Bcells_Human0.89486819
93ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89406124
94VDR_22108803_ChIP-Seq_LS180_Human0.89025598
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88433106
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88069029
97TP53_18474530_ChIP-ChIP_U2OS_Human0.87022867
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.86964030
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86471060
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85617529
101AHR_22903824_ChIP-Seq_MCF-7_Human0.85499786
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85419316
103TET1_21490601_ChIP-Seq_MESCs_Mouse0.85107412
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84809970
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84749691
106POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84654422
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.84385436
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84031408
109SMAD_19615063_ChIP-ChIP_OVARY_Human0.83921736
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83441645
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81698242
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81646414
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81646414
114JUN_21703547_ChIP-Seq_K562_Human0.81287406
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80956850
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80184782
117TP53_23651856_ChIP-Seq_MEFs_Mouse0.79418453
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78261405
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78084542
120ESR2_21235772_ChIP-Seq_MCF-7_Human0.77699229
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77151084
122SOX9_26525672_Chip-Seq_HEART_Mouse0.76921823
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76591554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.16119467
2MP0003880_abnormal_central_pattern4.52618487
3MP0003635_abnormal_synaptic_transmissio3.99818040
4MP0004270_analgesia3.63763660
5MP0009745_abnormal_behavioral_response3.34811387
6MP0001968_abnormal_touch/_nociception3.20809634
7MP0002064_seizures3.18277699
8MP0002063_abnormal_learning/memory/cond3.13117950
9MP0009046_muscle_twitch2.91282498
10MP0002734_abnormal_mechanical_nocicepti2.73849695
11MP0002572_abnormal_emotion/affect_behav2.73617247
12MP0002272_abnormal_nervous_system2.67964823
13MP0002736_abnormal_nociception_after2.65979242
14MP0005423_abnormal_somatic_nervous2.60476402
15MP0002735_abnormal_chemical_nociception2.50130058
16MP0002822_catalepsy2.42706514
17MP0001486_abnormal_startle_reflex2.39293649
18MP0001501_abnormal_sleep_pattern2.29732476
19MP0002733_abnormal_thermal_nociception2.25765236
20MP0001970_abnormal_pain_threshold2.17621175
21MP0001440_abnormal_grooming_behavior2.12657820
22MP0009780_abnormal_chondrocyte_physiolo2.07839694
23MP0002909_abnormal_adrenal_gland2.00310389
24MP0002067_abnormal_sensory_capabilities1.96191598
25MP0005646_abnormal_pituitary_gland1.90836535
26MP0006276_abnormal_autonomic_nervous1.90356151
27MP0003122_maternal_imprinting1.84880960
28MP0008569_lethality_at_weaning1.82152047
29MP0004858_abnormal_nervous_system1.78949215
30MP0002184_abnormal_innervation1.78844162
31MP0002557_abnormal_social/conspecific_i1.76134948
32MP0004811_abnormal_neuron_physiology1.73335643
33MP0003329_amyloid_beta_deposits1.67236163
34MP0005645_abnormal_hypothalamus_physiol1.65191218
35MP0001984_abnormal_olfaction1.62412495
36MP0005386_behavior/neurological_phenoty1.61898134
37MP0004924_abnormal_behavior1.61898134
38MP0005503_abnormal_tendon_morphology1.58048206
39MP0003879_abnormal_hair_cell1.56096757
40MP0003787_abnormal_imprinting1.54754551
41MP0000955_abnormal_spinal_cord1.54257100
42MP0000778_abnormal_nervous_system1.53218873
43MP0001529_abnormal_vocalization1.50724217
44MP0008438_abnormal_cutaneous_collagen1.50516884
45MP0001542_abnormal_bone_strength1.46784426
46MP0001502_abnormal_circadian_rhythm1.46183098
47MP0002653_abnormal_ependyma_morphology1.43906111
48MP0005257_abnormal_intraocular_pressure1.40555748
49MP0002882_abnormal_neuron_morphology1.38761207
50MP0002066_abnormal_motor_capabilities/c1.37610296
51MP0004142_abnormal_muscle_tone1.36315440
52MP0001958_emphysema1.32238065
53MP0001299_abnormal_eye_distance/1.31496183
54MP0004885_abnormal_endolymph1.30270893
55MP0003633_abnormal_nervous_system1.29454344
56MP0001905_abnormal_dopamine_level1.28271294
57MP0003283_abnormal_digestive_organ1.26704154
58MP0000013_abnormal_adipose_tissue1.22038229
59MP0002295_abnormal_pulmonary_circulatio1.19971189
60MP0010386_abnormal_urinary_bladder1.17806431
61MP0002638_abnormal_pupillary_reflex1.10465198
62MP0000751_myopathy1.06663664
63MP0005551_abnormal_eye_electrophysiolog1.06546017
64MP0003631_nervous_system_phenotype1.06478140
65MP0001188_hyperpigmentation1.06237648
66MP0002837_dystrophic_cardiac_calcinosis1.03253346
67MP0000026_abnormal_inner_ear1.01251093
68MP0002229_neurodegeneration1.00969944
69MP0004145_abnormal_muscle_electrophysio1.00418100
70MP0002152_abnormal_brain_morphology0.98899195
71MP0005535_abnormal_body_temperature0.97663138
72MP0001986_abnormal_taste_sensitivity0.95087037
73MP0002069_abnormal_eating/drinking_beha0.94357762
74MP0004133_heterotaxia0.93634540
75MP0003634_abnormal_glial_cell0.91943509
76MP0003011_delayed_dark_adaptation0.91416296
77MP0006072_abnormal_retinal_apoptosis0.90600874
78MP0004742_abnormal_vestibular_system0.90183794
79MP0008961_abnormal_basal_metabolism0.88235350
80MP0002090_abnormal_vision0.86225011
81MP0000631_abnormal_neuroendocrine_gland0.85474405
82MP0005394_taste/olfaction_phenotype0.85133482
83MP0005499_abnormal_olfactory_system0.85133482
84MP0003279_aneurysm0.85123066
85MP0008872_abnormal_physiological_respon0.85094326
86MP0008874_decreased_physiological_sensi0.85082526
87MP0010030_abnormal_orbit_morphology0.84923816
88MP0004043_abnormal_pH_regulation0.84467115
89MP0005508_abnormal_skeleton_morphology0.84347614
90MP0003690_abnormal_glial_cell0.83916092
91MP0001963_abnormal_hearing_physiology0.81856600
92MP0003938_abnormal_ear_development0.80319745
93MP0003075_altered_response_to0.79256761
94MP0003942_abnormal_urinary_system0.79211049
95MP0004085_abnormal_heartbeat0.78975309
96MP0000534_abnormal_ureter_morphology0.78272400
97MP0005248_abnormal_Harderian_gland0.77493616
98MP0000639_abnormal_adrenal_gland0.76855603
99MP0002752_abnormal_somatic_nervous0.75722588
100MP0002876_abnormal_thyroid_physiology0.75519308
101MP0000920_abnormal_myelination0.73739303
102MP0003632_abnormal_nervous_system0.72567066
103MP0001664_abnormal_digestion0.71158639
104MP0001177_atelectasis0.71094690
105MP0009379_abnormal_foot_pigmentation0.69795776
106MP0003183_abnormal_peptide_metabolism0.69224735
107MP0000604_amyloidosis0.67754958
108MP0005379_endocrine/exocrine_gland_phen0.67151787
109MP0005595_abnormal_vascular_smooth0.66180088
110MP0001485_abnormal_pinna_reflex0.65072568
111MP0009250_abnormal_appendicular_skeleto0.64578139
112MP0005167_abnormal_blood-brain_barrier0.61414339
113MP0000049_abnormal_middle_ear0.60933071
114MP0000230_abnormal_systemic_arterial0.58957982
115MP0003137_abnormal_impulse_conducting0.58226995
116MP0005253_abnormal_eye_physiology0.58163303
117MP0004215_abnormal_myocardial_fiber0.56862909
118MP0001943_abnormal_respiration0.54404109
119MP0004233_abnormal_muscle_weight0.54148094
120MP0003121_genomic_imprinting0.53916733
121MP0003123_paternal_imprinting0.53474123
122MP0005171_absent_coat_pigmentation0.52448514
123MP0005623_abnormal_meninges_morphology0.50856873
124MP0003172_abnormal_lysosome_physiology0.49557348

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.84461262
2Myokymia (HP:0002411)7.76675354
3Focal seizures (HP:0007359)5.65831565
4Visual hallucinations (HP:0002367)5.47070874
5Atonic seizures (HP:0010819)4.94554918
6Epileptic encephalopathy (HP:0200134)4.61783951
7Absence seizures (HP:0002121)4.39029318
8Febrile seizures (HP:0002373)4.38654969
9Progressive cerebellar ataxia (HP:0002073)4.13239773
10Dialeptic seizures (HP:0011146)4.05829006
11Action tremor (HP:0002345)3.94266139
12Generalized tonic-clonic seizures (HP:0002069)3.93033250
13Supranuclear gaze palsy (HP:0000605)3.52673398
14Ankle clonus (HP:0011448)3.43736924
15Anxiety (HP:0000739)3.42169042
16Depression (HP:0000716)3.39679044
17Impaired vibration sensation in the lower limbs (HP:0002166)3.29333149
18Abnormal eating behavior (HP:0100738)3.18160191
19Dysmetria (HP:0001310)3.01940961
20Truncal ataxia (HP:0002078)3.00240151
21Broad-based gait (HP:0002136)2.99208627
22Dysdiadochokinesis (HP:0002075)2.98222919
23Gaze-evoked nystagmus (HP:0000640)2.97836671
24Amblyopia (HP:0000646)2.95697696
25Papilledema (HP:0001085)2.83612267
26Protrusio acetabuli (HP:0003179)2.76678085
27Poor eye contact (HP:0000817)2.75920923
28Pheochromocytoma (HP:0002666)2.73687089
29Abnormality of dentin (HP:0010299)2.72630861
30Postural instability (HP:0002172)2.72469688
31Neonatal short-limb short stature (HP:0008921)2.67582832
32Premature rupture of membranes (HP:0001788)2.67322260
33Urinary bladder sphincter dysfunction (HP:0002839)2.61242629
34Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.61001462
35Epileptiform EEG discharges (HP:0011182)2.56183840
36Atrophic scars (HP:0001075)2.55678092
37Hyperventilation (HP:0002883)2.55618693
38Megalencephaly (HP:0001355)2.55140229
39Torticollis (HP:0000473)2.55088321
40Abnormal social behavior (HP:0012433)2.53486234
41Impaired social interactions (HP:0000735)2.53486234
42Spastic gait (HP:0002064)2.51715221
43Hemiparesis (HP:0001269)2.51048649
44Sleep apnea (HP:0010535)2.50150892
45Agitation (HP:0000713)2.50032778
46Ventricular fibrillation (HP:0001663)2.50019805
47Focal dystonia (HP:0004373)2.49952644
48EEG with generalized epileptiform discharges (HP:0011198)2.47547746
49Polyphagia (HP:0002591)2.46051086
50Failure to thrive in infancy (HP:0001531)2.43782615
51Impaired smooth pursuit (HP:0007772)2.43193104
52Bradykinesia (HP:0002067)2.42986339
53Scanning speech (HP:0002168)2.36840075
54Mutism (HP:0002300)2.36730781
55Hypsarrhythmia (HP:0002521)2.36500887
56Abnormality of the lower motor neuron (HP:0002366)2.35272381
57Nuclear cataract (HP:0100018)2.35138525
58Urinary urgency (HP:0000012)2.34220978
59Neuroendocrine neoplasm (HP:0100634)2.33749168
60Limb dystonia (HP:0002451)2.33552313
61Progressive inability to walk (HP:0002505)2.31455591
62Excessive salivation (HP:0003781)2.27200010
63Drooling (HP:0002307)2.27200010
64Vascular tortuosity (HP:0004948)2.26989757
65Bladder diverticulum (HP:0000015)2.24343154
66Neurofibrillary tangles (HP:0002185)2.22697681
67Craniofacial dystonia (HP:0012179)2.21856436
68Hemiplegia (HP:0002301)2.21816429
69Intention tremor (HP:0002080)2.18848123
70Diplopia (HP:0000651)2.18002662
71Abnormality of binocular vision (HP:0011514)2.18002662
72Bowel diverticulosis (HP:0005222)2.17637416
73Mild short stature (HP:0003502)2.17107959
74Psychosis (HP:0000709)2.16081989
75Aplasia involving bones of the extremities (HP:0009825)2.15341524
76Aplasia involving bones of the upper limbs (HP:0009823)2.15341524
77Aplasia of the phalanges of the hand (HP:0009802)2.15341524
78Cerebral inclusion bodies (HP:0100314)2.14393129
79Abnormality of ocular smooth pursuit (HP:0000617)2.11652335
80Impaired vibratory sensation (HP:0002495)2.08188101
81Lower limb muscle weakness (HP:0007340)2.07156037
82Hypoventilation (HP:0002791)2.06955358
83Morphological abnormality of the middle ear (HP:0008609)2.06809371
84Genetic anticipation (HP:0003743)2.04690010
85Turricephaly (HP:0000262)2.04354807
86Delusions (HP:0000746)2.04183108
87Status epilepticus (HP:0002133)2.04172316
88Menstrual irregularities (HP:0000858)2.02751131
89Congenital primary aphakia (HP:0007707)2.02591828
90Obstructive sleep apnea (HP:0002870)2.02009249
91Stereotypic behavior (HP:0000733)2.00610363
92Coronal craniosynostosis (HP:0004440)1.98392132
93Genu recurvatum (HP:0002816)1.98033591
94Incomplete penetrance (HP:0003829)1.97719432
95Generalized myoclonic seizures (HP:0002123)1.97670281
96Medial flaring of the eyebrow (HP:0010747)1.97406040
97Resting tremor (HP:0002322)1.96740702
98Gait imbalance (HP:0002141)1.95022358
99Fetal akinesia sequence (HP:0001989)1.94156750
100Poor suck (HP:0002033)1.91740133
101Postural tremor (HP:0002174)1.91553238
102Annular pancreas (HP:0001734)1.89844170
103Nephrogenic diabetes insipidus (HP:0009806)1.89839323
104Abnormal EKG (HP:0003115)1.88625896
105Retinal dysplasia (HP:0007973)1.88222845
106Gait ataxia (HP:0002066)1.87477367
107Rapidly progressive (HP:0003678)1.86806229
108Specific learning disability (HP:0001328)1.86674378
109Clonus (HP:0002169)1.86512194
110Termporal pattern (HP:0011008)1.85198049
111Insidious onset (HP:0003587)1.85198049
112Dysmetric saccades (HP:0000641)1.84443196
113Insomnia (HP:0100785)1.84302531
114Abnormality of pain sensation (HP:0010832)1.84194958
115Impaired pain sensation (HP:0007328)1.84194958
116Hypercortisolism (HP:0001578)1.82179955
117Neuronal loss in central nervous system (HP:0002529)1.81608774
118Arterial tortuosity (HP:0005116)1.81298324
119Ulnar claw (HP:0001178)1.80764509
120Absent speech (HP:0001344)1.80541852
121Abnormality of the corticospinal tract (HP:0002492)1.80284375
122Pancreatic fibrosis (HP:0100732)1.79998961
123Spinal canal stenosis (HP:0003416)1.78905114
124Infantile muscular hypotonia (HP:0008947)1.78829909
125Rigidity (HP:0002063)1.78086784
126Bundle branch block (HP:0011710)1.78033820
127Inability to walk (HP:0002540)1.77204332
128Soft skin (HP:0000977)1.76051018
129Wide anterior fontanel (HP:0000260)1.75891409
130Shallow orbits (HP:0000586)1.73837196
131Overriding aorta (HP:0002623)1.73682741
132Septo-optic dysplasia (HP:0100842)1.71536677
133Aortic dissection (HP:0002647)1.70599333
134Delayed gross motor development (HP:0002194)1.70042117
135Spastic tetraplegia (HP:0002510)1.69113979
136Broad metatarsal (HP:0001783)1.68423747
137Hand muscle atrophy (HP:0009130)1.68163384
138Buphthalmos (HP:0000557)1.66890460
139Ankle contracture (HP:0006466)1.65843695
140Mitral regurgitation (HP:0001653)1.63445300
141Genital tract atresia (HP:0001827)1.62832410
142Aortic regurgitation (HP:0001659)1.61330197
143Vaginal atresia (HP:0000148)1.60862334
144Nephronophthisis (HP:0000090)1.60707985
145Split foot (HP:0001839)1.60575001
146Aplasia/Hypoplasia of the lens (HP:0008063)1.58759535
147Abnormality of the diencephalon (HP:0010662)1.56219126
148Elfin facies (HP:0004428)1.56147728
149Prolonged QT interval (HP:0001657)1.55896266
150Esotropia (HP:0000565)1.54284444
151Peripheral hypomyelination (HP:0007182)1.53184003
152Hyperextensible skin (HP:0000974)1.53004262

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.58818795
2MAP3K93.94535722
3EPHA43.87685335
4MAP3K42.77044082
5MINK12.62179491
6KSR22.45269847
7MAP3K122.39958984
8MAP2K72.36627680
9PRKD32.31834208
10ARAF2.30832436
11DAPK22.30602012
12MARK12.29286407
13GRK52.23523252
14PAK62.08746886
15TESK12.02468585
16NTRK22.00885805
17EPHB21.95382890
18MOS1.90824175
19NTRK11.83629094
20MAP2K41.77459072
21CASK1.77195719
22PLK21.64052113
23CAMKK11.60678542
24RIPK41.59884990
25MAP3K21.59824975
26CDK51.51087974
27UHMK11.47989300
28KSR11.45266268
29DAPK11.41690320
30PNCK1.37988387
31CDK191.37276167
32FES1.34584243
33MYLK1.32624545
34DYRK21.32038734
35MAPK131.27705576
36PRKCG1.24906985
37STK381.22758559
38PRPF4B1.19986055
39TNIK1.19980405
40MAP3K131.17639527
41ROCK21.15718095
42SGK4941.10003956
43SGK2231.10003956
44SIK21.08929084
45CAMKK21.06966974
46CAMK2A0.98739578
47MAP3K10.93714134
48CDK140.92848162
49PHKG20.92808484
50PHKG10.92808484
51PRKCH0.92648200
52CAMK10.90981870
53CAMK2B0.90273581
54CDK180.89654919
55ABL20.89273139
56PINK10.89203034
57TYRO30.88547991
58DDR20.88413623
59CDK150.87115961
60LMTK20.86716144
61PKN10.84874681
62PAK20.84189163
63TNK20.83523279
64PAK30.82417352
65RAF10.81985552
66DMPK0.81967067
67SGK20.81563917
68RET0.81206412
69OXSR10.78605895
70CDK11A0.77792719
71NME10.75544354
72PTK2B0.74334092
73STK110.74196804
74PTK20.72844586
75ROCK10.72173532
76TAOK10.72095707
77MAP3K110.70001319
78BCR0.69921788
79BRAF0.68521286
80BMPR20.67581392
81BCKDK0.65994533
82SGK30.64625683
83DYRK1A0.63832068
84PRKCE0.63828486
85SGK10.62714047
86FER0.61715710
87CAMK2G0.61648876
88WNK30.61425362
89RIPK10.60938431
90CSNK1G30.60804301
91CAMK2D0.58884441
92LIMK10.58550497
93MARK20.57878603
94PIM20.57531998
95PIK3CA0.57074083
96SIK30.56794315
97PDK10.56314519
98CSNK1G20.55999934
99PDPK10.55109017
100AKT30.54684985
101CDC42BPA0.54494880
102LATS20.53948801
103DYRK1B0.52804797
104MAP4K20.52164775
105MAP2K10.51036898
106ALK0.50844527
107WNK10.50414258
108STK38L0.49193395
109GRK70.49122960
110MUSK0.48472068
111PRKD10.47871024
112WNK40.47085334
113GRK10.46722434
114RPS6KA30.46571608
115RPS6KA20.45514740
116FGFR20.44728260
117CSNK1A1L0.44245716
118PDGFRA0.43315340
119ILK0.42314973
120PRKD20.42231774
121PRKG10.42181671
122CSNK1A10.42150940
123MAPK100.42133326
124PRKCZ0.41738453
125NEK60.39289881
126FYN0.39062531
127CAMK40.38809969
128DAPK30.38142456
129EPHA30.38099803
130CCNB10.36923255
131ADRBK10.36782181
132MAPK150.36400249
133PRKCA0.36049013
134PRKACA0.35610455
135SCYL20.35123512
136HIPK20.34210239

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.59894381
2Nicotine addiction_Homo sapiens_hsa050333.57857656
3GABAergic synapse_Homo sapiens_hsa047272.84081493
4Circadian entrainment_Homo sapiens_hsa047132.71761954
5Olfactory transduction_Homo sapiens_hsa047402.68362617
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65381828
7Long-term potentiation_Homo sapiens_hsa047202.57435261
8Glutamatergic synapse_Homo sapiens_hsa047242.51599533
9Morphine addiction_Homo sapiens_hsa050322.51586049
10Amphetamine addiction_Homo sapiens_hsa050312.47111524
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38825431
12Insulin secretion_Homo sapiens_hsa049112.33992944
13Dopaminergic synapse_Homo sapiens_hsa047282.17477990
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.12747785
15Salivary secretion_Homo sapiens_hsa049702.08982730
16Collecting duct acid secretion_Homo sapiens_hsa049661.94397957
17Cholinergic synapse_Homo sapiens_hsa047251.90792901
18Taste transduction_Homo sapiens_hsa047421.90590499
19Gastric acid secretion_Homo sapiens_hsa049711.84292547
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82030729
21Serotonergic synapse_Homo sapiens_hsa047261.72837359
22Cocaine addiction_Homo sapiens_hsa050301.72034904
23Long-term depression_Homo sapiens_hsa047301.62247277
24Renin secretion_Homo sapiens_hsa049241.62084460
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59717268
26Oxytocin signaling pathway_Homo sapiens_hsa049211.49082064
27Calcium signaling pathway_Homo sapiens_hsa040201.47081010
28GnRH signaling pathway_Homo sapiens_hsa049121.39257019
29Vibrio cholerae infection_Homo sapiens_hsa051101.33783175
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29378219
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28902050
32Cardiac muscle contraction_Homo sapiens_hsa042601.27387285
33Gap junction_Homo sapiens_hsa045401.25686842
34cAMP signaling pathway_Homo sapiens_hsa040241.19549550
35Type II diabetes mellitus_Homo sapiens_hsa049301.18633997
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17910197
37Estrogen signaling pathway_Homo sapiens_hsa049151.09832618
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08694131
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05438599
40Melanogenesis_Homo sapiens_hsa049161.05245153
41Oxidative phosphorylation_Homo sapiens_hsa001901.00931911
42Glioma_Homo sapiens_hsa052140.99586664
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98498676
44Hedgehog signaling pathway_Homo sapiens_hsa043400.98364705
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96493605
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.95382799
47Phototransduction_Homo sapiens_hsa047440.95038963
48Alzheimers disease_Homo sapiens_hsa050100.93317792
49Pancreatic secretion_Homo sapiens_hsa049720.92541175
50Protein export_Homo sapiens_hsa030600.91252415
51ECM-receptor interaction_Homo sapiens_hsa045120.88795232
52Thyroid hormone synthesis_Homo sapiens_hsa049180.88124959
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87272536
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85151549
55ErbB signaling pathway_Homo sapiens_hsa040120.85003773
56Hippo signaling pathway_Homo sapiens_hsa043900.84987965
57Axon guidance_Homo sapiens_hsa043600.84215907
58Protein digestion and absorption_Homo sapiens_hsa049740.81839008
59Parkinsons disease_Homo sapiens_hsa050120.80480268
60Nitrogen metabolism_Homo sapiens_hsa009100.79765128
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77794974
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76975702
63Dorso-ventral axis formation_Homo sapiens_hsa043200.76717423
64Oocyte meiosis_Homo sapiens_hsa041140.76612781
65Type I diabetes mellitus_Homo sapiens_hsa049400.76155346
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.73061892
67Basal cell carcinoma_Homo sapiens_hsa052170.66512255
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66329381
69Dilated cardiomyopathy_Homo sapiens_hsa054140.66046393
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64990982
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62306295
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61613196
73Butanoate metabolism_Homo sapiens_hsa006500.61553731
74Glucagon signaling pathway_Homo sapiens_hsa049220.61443509
75MAPK signaling pathway_Homo sapiens_hsa040100.60076605
76Choline metabolism in cancer_Homo sapiens_hsa052310.59553036
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58400310
78Folate biosynthesis_Homo sapiens_hsa007900.56454213
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54789371
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54773563
81Tight junction_Homo sapiens_hsa045300.54189298
82Alcoholism_Homo sapiens_hsa050340.54066707
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.53865404
84Ras signaling pathway_Homo sapiens_hsa040140.52114924
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50729962
86Huntingtons disease_Homo sapiens_hsa050160.50568489
87Prion diseases_Homo sapiens_hsa050200.50075811
88beta-Alanine metabolism_Homo sapiens_hsa004100.48778842
89Focal adhesion_Homo sapiens_hsa045100.47934952
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47358855
91Circadian rhythm_Homo sapiens_hsa047100.46749177
92Mineral absorption_Homo sapiens_hsa049780.46194985
93Endocytosis_Homo sapiens_hsa041440.45329930
94VEGF signaling pathway_Homo sapiens_hsa043700.43949113
95Bile secretion_Homo sapiens_hsa049760.42692622
96Lysosome_Homo sapiens_hsa041420.42173851
97Sulfur relay system_Homo sapiens_hsa041220.42033250
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41323986
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40385772
100Inositol phosphate metabolism_Homo sapiens_hsa005620.40206953
101Rap1 signaling pathway_Homo sapiens_hsa040150.40072746
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.39378517
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39232283
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38137786
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.37811712
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37118610
107Vitamin B6 metabolism_Homo sapiens_hsa007500.36378511
108Phagosome_Homo sapiens_hsa041450.36052516
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34627751
110mTOR signaling pathway_Homo sapiens_hsa041500.34535733
111Rheumatoid arthritis_Homo sapiens_hsa053230.34297282
112Ovarian steroidogenesis_Homo sapiens_hsa049130.34104276
113Insulin signaling pathway_Homo sapiens_hsa049100.33729936
114Wnt signaling pathway_Homo sapiens_hsa043100.33587475
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32741674
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32237962
117Endometrial cancer_Homo sapiens_hsa052130.29060443
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28042206
119Renal cell carcinoma_Homo sapiens_hsa052110.26511493
120Non-small cell lung cancer_Homo sapiens_hsa052230.26463988
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26124554
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25732933
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25397641
124Regulation of autophagy_Homo sapiens_hsa041400.24859801

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