TCEAL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. This family is comprised of nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternatively splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.53475198
2energy coupled proton transport, down electrochemical gradient (GO:0015985)3.90819559
3ATP synthesis coupled proton transport (GO:0015986)3.90819559
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.89533581
5chaperone-mediated protein transport (GO:0072321)3.52449587
6respiratory electron transport chain (GO:0022904)3.45017342
7electron transport chain (GO:0022900)3.40650668
8neuron recognition (GO:0008038)3.26415829
9pyrimidine nucleobase catabolic process (GO:0006208)3.22656416
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.10033094
11postsynaptic membrane organization (GO:0001941)3.08685770
12axonal fasciculation (GO:0007413)3.06463301
13establishment of protein localization to mitochondrial membrane (GO:0090151)2.95226850
14protein complex biogenesis (GO:0070271)2.86292305
15glutamate secretion (GO:0014047)2.85982435
16regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84595524
17presynaptic membrane organization (GO:0097090)2.81997868
18viral transcription (GO:0019083)2.78596108
19presynaptic membrane assembly (GO:0097105)2.75801362
20transmission of nerve impulse (GO:0019226)2.73383971
21translational termination (GO:0006415)2.73133116
22synaptic vesicle maturation (GO:0016188)2.69760864
23nucleobase catabolic process (GO:0046113)2.66956238
24ribosomal small subunit biogenesis (GO:0042274)2.66177783
25cotranslational protein targeting to membrane (GO:0006613)2.64316378
26neuron cell-cell adhesion (GO:0007158)2.64156121
27protein targeting to ER (GO:0045047)2.60725742
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60615229
29cerebellar Purkinje cell layer development (GO:0021680)2.59612564
30substrate-independent telencephalic tangential migration (GO:0021826)2.58911269
31substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.58911269
32mitochondrial respiratory chain complex assembly (GO:0033108)2.55247451
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.54255407
34neurofilament cytoskeleton organization (GO:0060052)2.52703622
35establishment of protein localization to endoplasmic reticulum (GO:0072599)2.52549221
36protein localization to synapse (GO:0035418)2.48949260
37protein localization to endoplasmic reticulum (GO:0070972)2.47995927
38nonmotile primary cilium assembly (GO:0035058)2.46061155
39establishment of mitochondrion localization (GO:0051654)2.46009664
40cellular potassium ion homeostasis (GO:0030007)2.43217280
41mitochondrial respiratory chain complex I assembly (GO:0032981)2.40885974
42NADH dehydrogenase complex assembly (GO:0010257)2.40885974
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.40885974
44synaptic vesicle docking involved in exocytosis (GO:0016081)2.39792015
45hydrogen ion transmembrane transport (GO:1902600)2.36833815
46axon extension (GO:0048675)2.36583347
47maturation of SSU-rRNA (GO:0030490)2.36350051
48positive regulation of synapse assembly (GO:0051965)2.34110363
49retinal ganglion cell axon guidance (GO:0031290)2.33418679
50vocalization behavior (GO:0071625)2.33351675
51ionotropic glutamate receptor signaling pathway (GO:0035235)2.30174848
52protein neddylation (GO:0045116)2.29406743
53negative regulation of synaptic transmission, GABAergic (GO:0032229)2.26170509
54short-term memory (GO:0007614)2.25800236
55synapse assembly (GO:0007416)2.25334197
56dendritic spine morphogenesis (GO:0060997)2.24530242
57auditory behavior (GO:0031223)2.23825451
58synaptic vesicle exocytosis (GO:0016079)2.22228861
59neuronal ion channel clustering (GO:0045161)2.21272618
60translational elongation (GO:0006414)2.18800948
61regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.18522378
62regulation of axon extension involved in axon guidance (GO:0048841)2.17646032
63negative regulation of appetite (GO:0032099)2.17419891
64negative regulation of response to food (GO:0032096)2.17419891
65startle response (GO:0001964)2.17232600
66regulation of microtubule-based movement (GO:0060632)2.16750115
67ATP biosynthetic process (GO:0006754)2.16325375
68neuronal action potential propagation (GO:0019227)2.15765933
69gamma-aminobutyric acid transport (GO:0015812)2.15522443
70metanephric mesenchyme development (GO:0072075)2.14886990
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.14019329
72regulation of axon guidance (GO:1902667)2.12503725
73cellular protein complex disassembly (GO:0043624)2.11793323
74spinal cord development (GO:0021510)2.11612322
75regulation of cilium movement (GO:0003352)2.11444967
76synaptic transmission, glutamatergic (GO:0035249)2.11320131
77axon cargo transport (GO:0008088)2.08825516
78viral life cycle (GO:0019058)2.07891680
79mitochondrion transport along microtubule (GO:0047497)2.07640281
80establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.07640281
81water-soluble vitamin biosynthetic process (GO:0042364)2.07185991
82dendrite morphogenesis (GO:0048813)2.06913081
83anterograde axon cargo transport (GO:0008089)2.06801548
84glutamate receptor signaling pathway (GO:0007215)2.06510292
85cell migration in hindbrain (GO:0021535)2.05903062
86innervation (GO:0060384)2.05085057
87cerebral cortex radially oriented cell migration (GO:0021799)2.04941007
88neuron projection extension involved in neuron projection guidance (GO:1902284)2.04811782
89axon extension involved in axon guidance (GO:0048846)2.04811782
90behavioral response to nicotine (GO:0035095)2.03744624
91kidney mesenchyme development (GO:0072074)2.03330390
92proton transport (GO:0015992)2.02663084
93negative regulation of axon extension involved in axon guidance (GO:0048843)2.02382309
94synapse organization (GO:0050808)2.01997630
95neurotransmitter secretion (GO:0007269)2.01330412
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.01077248
97neuron-neuron synaptic transmission (GO:0007270)2.00914897
98hydrogen transport (GO:0006818)2.00707163
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)1.99011438
100locomotory exploration behavior (GO:0035641)1.98574675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.01264398
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.69337599
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.65470247
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.51464184
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.46281387
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.44390557
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.29483234
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29256728
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18311429
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17147954
11GBX2_23144817_ChIP-Seq_PC3_Human2.15575908
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14439661
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.14138956
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04053430
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04053430
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03304048
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97516735
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93843820
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.87926509
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84695317
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83847123
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80857714
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77802262
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.74332290
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73585797
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.72997016
27REST_21632747_ChIP-Seq_MESCs_Mouse1.68265579
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64620697
29RNF2_27304074_Chip-Seq_NSC_Mouse1.62556897
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61437903
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61277239
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59812666
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54679624
34FUS_26573619_Chip-Seq_HEK293_Human1.45790418
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.45150764
36TAF15_26573619_Chip-Seq_HEK293_Human1.44834550
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.41558862
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39291609
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37881534
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.28730231
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.28520042
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25730348
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23448702
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22291113
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.21825958
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21226551
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19241882
48ZNF274_21170338_ChIP-Seq_K562_Hela1.18510914
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18421428
50P300_19829295_ChIP-Seq_ESCs_Human1.15396872
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14477508
52EWS_26573619_Chip-Seq_HEK293_Human1.10772873
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.07516312
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05519891
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.03245886
56RING1B_27294783_Chip-Seq_NPCs_Mouse1.02756817
57OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02380997
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01344795
59* SMAD4_21799915_ChIP-Seq_A2780_Human1.01239808
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00988954
61IGF1R_20145208_ChIP-Seq_DFB_Human0.99336670
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97616508
63ERG_21242973_ChIP-ChIP_JURKAT_Human0.97300508
64TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97207085
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96543084
66NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95338923
67ETS1_20019798_ChIP-Seq_JURKAT_Human0.95252501
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95032408
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94557017
70* SMAD3_21741376_ChIP-Seq_EPCs_Human0.94508868
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92392673
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91347323
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90057399
74CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89350961
75EP300_21415370_ChIP-Seq_HL-1_Mouse0.88180318
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87990187
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86706585
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86601481
79VDR_22108803_ChIP-Seq_LS180_Human0.85929175
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85926247
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85196687
82AR_25329375_ChIP-Seq_VCAP_Human0.84665932
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83931118
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81931349
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81015619
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.80193591
87SOX9_26525672_Chip-Seq_HEART_Mouse0.80080423
88POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.78632260
89JUN_21703547_ChIP-Seq_K562_Human0.78301712
90REST_19997604_ChIP-ChIP_NEURONS_Mouse0.77044853
91CREB1_15753290_ChIP-ChIP_HEK293T_Human0.76961297
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76464077
93IKZF1_21737484_ChIP-ChIP_HCT116_Human0.75539456
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75197604
95YAP1_20516196_ChIP-Seq_MESCs_Mouse0.75130862
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74896825
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.74738322
98TBX3_20139965_ChIP-Seq_MESCs_Mouse0.72571885
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.72394675
100WT1_25993318_ChIP-Seq_PODOCYTE_Human0.72296509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity2.65504707
2MP0003122_maternal_imprinting2.46385890
3MP0003880_abnormal_central_pattern2.28116729
4MP0009379_abnormal_foot_pigmentation2.18184091
5MP0009780_abnormal_chondrocyte_physiolo2.14843580
6MP0004270_analgesia2.13199194
7MP0000778_abnormal_nervous_system1.98762078
8MP0003123_paternal_imprinting1.93536286
9MP0003635_abnormal_synaptic_transmissio1.87833403
10MP0003787_abnormal_imprinting1.84029972
11MP0005423_abnormal_somatic_nervous1.83992317
12MP0002909_abnormal_adrenal_gland1.74035700
13MP0002736_abnormal_nociception_after1.72700244
14MP0002734_abnormal_mechanical_nocicepti1.68630096
15MP0002272_abnormal_nervous_system1.66574285
16MP0003121_genomic_imprinting1.64452941
17MP0006292_abnormal_olfactory_placode1.63112312
18MP0009046_muscle_twitch1.61547724
19MP0001984_abnormal_olfaction1.60616143
20MP0003011_delayed_dark_adaptation1.59646618
21MP0005503_abnormal_tendon_morphology1.58617687
22MP0009745_abnormal_behavioral_response1.58129421
23MP0001968_abnormal_touch/_nociception1.56151508
24MP0004885_abnormal_endolymph1.55878772
25MP0002572_abnormal_emotion/affect_behav1.54248717
26MP0002063_abnormal_learning/memory/cond1.54038610
27MP0001529_abnormal_vocalization1.52231370
28MP0005646_abnormal_pituitary_gland1.50508528
29MP0002184_abnormal_innervation1.50069705
30MP0006276_abnormal_autonomic_nervous1.48657979
31MP0002064_seizures1.46959360
32MP0010386_abnormal_urinary_bladder1.42709413
33MP0002938_white_spotting1.42643015
34MP0001486_abnormal_startle_reflex1.39450734
35MP0003136_yellow_coat_color1.36936863
36MP0002735_abnormal_chemical_nociception1.36728026
37MP0002557_abnormal_social/conspecific_i1.35718920
38MP0010030_abnormal_orbit_morphology1.32830664
39MP0003942_abnormal_urinary_system1.32667588
40MP0008789_abnormal_olfactory_epithelium1.31518623
41MP0000955_abnormal_spinal_cord1.30337843
42MP0003283_abnormal_digestive_organ1.28872171
43MP0001299_abnormal_eye_distance/1.28442502
44MP0001485_abnormal_pinna_reflex1.26360853
45MP0001905_abnormal_dopamine_level1.24256916
46MP0002837_dystrophic_cardiac_calcinosis1.21333668
47MP0005394_taste/olfaction_phenotype1.20375985
48MP0005499_abnormal_olfactory_system1.20375985
49MP0000049_abnormal_middle_ear1.18036180
50MP0001970_abnormal_pain_threshold1.17788549
51MP0006072_abnormal_retinal_apoptosis1.16065717
52MP0004133_heterotaxia1.15053452
53MP0004142_abnormal_muscle_tone1.14896554
54MP0001440_abnormal_grooming_behavior1.14687167
55MP0003879_abnormal_hair_cell1.14472678
56MP0002638_abnormal_pupillary_reflex1.14235848
57MP0002882_abnormal_neuron_morphology1.13985514
58MP0009250_abnormal_appendicular_skeleto1.12852414
59MP0005551_abnormal_eye_electrophysiolog1.11575629
60MP0000534_abnormal_ureter_morphology1.09654706
61MP0002067_abnormal_sensory_capabilities1.08260281
62MP0002160_abnormal_reproductive_system1.08100191
63MP0001188_hyperpigmentation1.07053524
64MP0002733_abnormal_thermal_nociception1.06286866
65MP0000631_abnormal_neuroendocrine_gland1.05875318
66MP0002822_catalepsy1.04444660
67MP0008438_abnormal_cutaneous_collagen1.02854663
68MP0002752_abnormal_somatic_nervous1.01875883
69MP0004811_abnormal_neuron_physiology1.01021515
70MP0008877_abnormal_DNA_methylation1.00229615
71MP0003755_abnormal_palate_morphology1.00130932
72MP0000026_abnormal_inner_ear0.98269226
73MP0002152_abnormal_brain_morphology0.95621939
74MP0002233_abnormal_nose_morphology0.95173186
75MP0002295_abnormal_pulmonary_circulatio0.94820138
76MP0001542_abnormal_bone_strength0.94634249
77MP0005257_abnormal_intraocular_pressure0.94292144
78MP0000566_synostosis0.93920113
79MP0001502_abnormal_circadian_rhythm0.93765885
80MP0003385_abnormal_body_wall0.93017479
81MP0003938_abnormal_ear_development0.91414769
82MP0004272_abnormal_basement_membrane0.90505886
83MP0001293_anophthalmia0.89022325
84MP0005623_abnormal_meninges_morphology0.88067059
85MP0003937_abnormal_limbs/digits/tail_de0.86154098
86MP0002234_abnormal_pharynx_morphology0.85810294
87MP0001963_abnormal_hearing_physiology0.85810249
88MP0002066_abnormal_motor_capabilities/c0.85714463
89MP0009053_abnormal_anal_canal0.85704016
90MP0003861_abnormal_nervous_system0.84018952
91MP0005187_abnormal_penis_morphology0.81854485
92MP0000762_abnormal_tongue_morphology0.80291317
93MP0002697_abnormal_eye_size0.79216443
94MP0004924_abnormal_behavior0.78221394
95MP0005386_behavior/neurological_phenoty0.78221394
96MP0003186_abnormal_redox_activity0.76765357
97MP0000462_abnormal_digestive_system0.76667622
98MP0002102_abnormal_ear_morphology0.76371923
99MP0002090_abnormal_vision0.75486244
100MP0005253_abnormal_eye_physiology0.75463362

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.22938994
2Acute necrotizing encephalopathy (HP:0006965)3.60007307
3Abnormal mitochondria in muscle tissue (HP:0008316)3.16658441
4Progressive macrocephaly (HP:0004481)3.08082589
5Mitochondrial inheritance (HP:0001427)2.94087728
6Acute encephalopathy (HP:0006846)2.91194575
7Focal motor seizures (HP:0011153)2.79715538
8Gait imbalance (HP:0002141)2.51012877
9Increased CSF lactate (HP:0002490)2.42641886
10Focal seizures (HP:0007359)2.41637192
11Increased hepatocellular lipid droplets (HP:0006565)2.39751812
12Hepatocellular necrosis (HP:0001404)2.36638605
13Limb dystonia (HP:0002451)2.35910697
14Medial flaring of the eyebrow (HP:0010747)2.28249115
15Polyphagia (HP:0002591)2.24781429
16Renal Fanconi syndrome (HP:0001994)2.23777876
17Morphological abnormality of the middle ear (HP:0008609)2.22779090
18Hepatic necrosis (HP:0002605)2.16326809
19Vaginal atresia (HP:0000148)2.16076894
20Congenital primary aphakia (HP:0007707)2.13257409
21Genital tract atresia (HP:0001827)2.13059426
22Epileptic encephalopathy (HP:0200134)2.12386077
23Abnormality of midbrain morphology (HP:0002418)2.10049694
24Molar tooth sign on MRI (HP:0002419)2.10049694
25Pancreatic fibrosis (HP:0100732)2.06290038
26Cerebral edema (HP:0002181)2.06067374
27Action tremor (HP:0002345)2.04384202
28Lipid accumulation in hepatocytes (HP:0006561)2.04281339
29Macrocytic anemia (HP:0001972)2.01384411
30Generalized tonic-clonic seizures (HP:0002069)2.00169088
31Nephrogenic diabetes insipidus (HP:0009806)1.98520915
32Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97636196
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97636196
34Poor suck (HP:0002033)1.97227031
35Abnormality of cells of the erythroid lineage (HP:0012130)1.95306192
36Abnormality of the labia minora (HP:0012880)1.87741832
37Sleep apnea (HP:0010535)1.85038384
38Septo-optic dysplasia (HP:0100842)1.83384345
39Anophthalmia (HP:0000528)1.83261229
40Abnormal eating behavior (HP:0100738)1.82300306
41Leukodystrophy (HP:0002415)1.81987376
42Reticulocytopenia (HP:0001896)1.80077576
43True hermaphroditism (HP:0010459)1.76547223
44Abnormality of dentin (HP:0010299)1.76500616
45Abnormality of the corticospinal tract (HP:0002492)1.75652247
46Epileptiform EEG discharges (HP:0011182)1.71629854
47Turricephaly (HP:0000262)1.71398564
48Febrile seizures (HP:0002373)1.67742825
49Nephronophthisis (HP:0000090)1.65714143
50X-linked dominant inheritance (HP:0001423)1.65182799
51Absence seizures (HP:0002121)1.64036722
52Progressive cerebellar ataxia (HP:0002073)1.61794915
53Atonic seizures (HP:0010819)1.61762685
54EEG with generalized epileptiform discharges (HP:0011198)1.61507192
55Dialeptic seizures (HP:0011146)1.60641932
56Abnormality of renal resorption (HP:0011038)1.60325108
57Respiratory failure (HP:0002878)1.60296781
58Enlarged penis (HP:0000040)1.58195859
59Agitation (HP:0000713)1.57527416
60Increased intramyocellular lipid droplets (HP:0012240)1.57055848
61Concave nail (HP:0001598)1.56938473
62Stenosis of the external auditory canal (HP:0000402)1.56504374
63Hemiparesis (HP:0001269)1.55677173
64Optic disc pallor (HP:0000543)1.55172525
65Abnormal number of erythroid precursors (HP:0012131)1.54093537
66Protrusio acetabuli (HP:0003179)1.53871449
67Delayed gross motor development (HP:0002194)1.52427017
68Facial cleft (HP:0002006)1.52276713
69Absent eyebrow (HP:0002223)1.51866461
70Drooling (HP:0002307)1.51595305
71Spastic tetraplegia (HP:0002510)1.50404927
72Oligodactyly (hands) (HP:0001180)1.49734040
73Myotonia (HP:0002486)1.49503815
74Occipital encephalocele (HP:0002085)1.49347200
75Hypsarrhythmia (HP:0002521)1.47263305
76Patent foramen ovale (HP:0001655)1.46927651
77Coronal craniosynostosis (HP:0004440)1.46832745
78Pancreatic cysts (HP:0001737)1.46708108
79Sclerocornea (HP:0000647)1.46688553
80Failure to thrive in infancy (HP:0001531)1.45956715
81Soft skin (HP:0000977)1.44932692
82Ulnar claw (HP:0001178)1.44211782
83Premature rupture of membranes (HP:0001788)1.44028290
84Aplasia/Hypoplasia of the lens (HP:0008063)1.43097849
85Anxiety (HP:0000739)1.43045826
86Infantile muscular hypotonia (HP:0008947)1.42148365
87Torticollis (HP:0000473)1.41709411
88Rib fusion (HP:0000902)1.41652232
89Degeneration of the lateral corticospinal tracts (HP:0002314)1.40128641
90Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.40128641
91Hydroureter (HP:0000072)1.40118477
92Adrenal hypoplasia (HP:0000835)1.39168180
93Specific learning disability (HP:0001328)1.39056313
94Focal dystonia (HP:0004373)1.38906760
95Bifid tongue (HP:0010297)1.37585337
96Hyperglycinemia (HP:0002154)1.37470186
97Postural tremor (HP:0002174)1.37286371
98Neonatal short-limb short stature (HP:0008921)1.36948058
99Bladder diverticulum (HP:0000015)1.36188788
100Bowel diverticulosis (HP:0005222)1.35405850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.66897939
2CASK3.42148458
3WNK32.35863427
4PNCK2.20103539
5TNIK2.17712060
6SIK22.16795729
7LIMK12.04475722
8STK162.01575443
9VRK21.95489358
10EPHB21.93108572
11DYRK21.88307860
12NTRK11.87431853
13NTRK21.76842798
14MYLK1.72347701
15PAK31.67999650
16PRKD31.62571351
17MINK11.62477852
18PHKG21.57408163
19PHKG11.57408163
20NTRK31.52817785
21EPHA41.48696068
22MAP2K71.45962505
23PRKCG1.44589160
24LATS21.44306829
25UHMK11.42249816
26TESK11.37866643
27MAP3K41.34949328
28PINK11.33577571
29DMPK1.32914339
30CSNK1G21.21661866
31MAP3K121.21422420
32PLK21.20842897
33PAK61.13017712
34MAP3K91.07599185
35ARAF1.06056791
36ABL21.00705660
37BCR0.99240611
38MAPK130.95498727
39FGFR20.94830388
40CAMK2B0.92382249
41CDK50.91590372
42FRK0.91379825
43CAMK2G0.89906671
44PIK3CA0.87345789
45PRKCE0.86939417
46CAMK2D0.86386780
47CDK150.85511081
48CDK140.84960711
49CDK180.84889886
50CSNK1E0.84482800
51CDK11A0.83804875
52PAK20.82366916
53CAMK2A0.82365518
54MUSK0.81819884
55NME10.81621674
56ILK0.79369368
57TIE10.78842330
58CSNK1G30.78698251
59TRIM280.77361010
60PTK20.76519977
61SGK2230.76275404
62SGK4940.76275404
63NEK20.73291717
64CSNK1G10.72943723
65STK38L0.71314401
66MAP4K20.69967561
67AKT30.68389847
68ROCK20.67360840
69GRK10.66002919
70NUAK10.63929275
71GRK50.63827769
72CSNK1A1L0.63243918
73MAPK150.63158138
74DDR20.62981162
75WNK40.62954478
76PLK30.61899641
77CDC70.60129297
78CAMK10.59754720
79DAPK30.59604017
80MAPKAPK50.59363687
81STK390.57790848
82TAF10.56745038
83DYRK1A0.56068745
84MOS0.55650769
85TYRO30.53713555
86VRK10.53625431
87INSRR0.51337407
88DAPK20.51303396
89CSNK1A10.50827098
90MKNK20.50336652
91BMPR1B0.49719173
92PKN10.47447752
93PRKCI0.46317745
94ERBB30.46016524
95CDK30.45617810
96FER0.44994478
97BCKDK0.43405786
98PRKCZ0.43353440
99PRKACA0.42948638
100PDK20.42266161

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.77620976
2Parkinsons disease_Homo sapiens_hsa050123.08515986
3Ribosome_Homo sapiens_hsa030102.96581769
4Cardiac muscle contraction_Homo sapiens_hsa042602.71779764
5Protein export_Homo sapiens_hsa030602.51210679
6Alzheimers disease_Homo sapiens_hsa050102.48757191
7Nicotine addiction_Homo sapiens_hsa050332.45105147
8Huntingtons disease_Homo sapiens_hsa050162.24523477
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75141622
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72804628
11Synaptic vesicle cycle_Homo sapiens_hsa047211.72571167
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59214557
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56591403
14GABAergic synapse_Homo sapiens_hsa047271.48937820
15Insulin secretion_Homo sapiens_hsa049111.47730104
16RNA polymerase_Homo sapiens_hsa030201.44099116
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40474959
18Circadian entrainment_Homo sapiens_hsa047131.35836758
19Cocaine addiction_Homo sapiens_hsa050301.32567501
20Glutamatergic synapse_Homo sapiens_hsa047241.31082142
21Folate biosynthesis_Homo sapiens_hsa007901.30261572
22Dopaminergic synapse_Homo sapiens_hsa047281.26970280
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25579167
24Amphetamine addiction_Homo sapiens_hsa050311.23924060
25Proteasome_Homo sapiens_hsa030501.21689314
26Collecting duct acid secretion_Homo sapiens_hsa049661.14552411
27Morphine addiction_Homo sapiens_hsa050321.13928026
28Phototransduction_Homo sapiens_hsa047441.11579034
29Fatty acid elongation_Homo sapiens_hsa000621.09158758
30Butanoate metabolism_Homo sapiens_hsa006501.04894019
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02572665
32Axon guidance_Homo sapiens_hsa043600.99230669
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98824718
34Propanoate metabolism_Homo sapiens_hsa006400.97890045
35Vibrio cholerae infection_Homo sapiens_hsa051100.97544562
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96094460
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95598255
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90973499
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89917225
40beta-Alanine metabolism_Homo sapiens_hsa004100.87363176
41Dilated cardiomyopathy_Homo sapiens_hsa054140.86483515
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86067199
43Steroid biosynthesis_Homo sapiens_hsa001000.83238705
44Vitamin B6 metabolism_Homo sapiens_hsa007500.82721620
45Pyruvate metabolism_Homo sapiens_hsa006200.82032030
46Serotonergic synapse_Homo sapiens_hsa047260.81868009
47Hedgehog signaling pathway_Homo sapiens_hsa043400.81241691
48Taste transduction_Homo sapiens_hsa047420.77063388
49Basal cell carcinoma_Homo sapiens_hsa052170.75977358
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.74358537
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74233545
52Sulfur relay system_Homo sapiens_hsa041220.73762241
53Hippo signaling pathway_Homo sapiens_hsa043900.73457370
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71613422
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71408962
56ECM-receptor interaction_Homo sapiens_hsa045120.71283077
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70856837
58Cholinergic synapse_Homo sapiens_hsa047250.70582988
59Basal transcription factors_Homo sapiens_hsa030220.67613948
60Circadian rhythm_Homo sapiens_hsa047100.67267047
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67037182
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65769631
63Arginine and proline metabolism_Homo sapiens_hsa003300.65366227
64Salivary secretion_Homo sapiens_hsa049700.64387316
65Tight junction_Homo sapiens_hsa045300.64187748
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64183062
67Peroxisome_Homo sapiens_hsa041460.61780579
68Gap junction_Homo sapiens_hsa045400.61405970
69Long-term depression_Homo sapiens_hsa047300.61336668
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60030215
71Renin secretion_Homo sapiens_hsa049240.59893649
72Wnt signaling pathway_Homo sapiens_hsa043100.58996477
73Fatty acid metabolism_Homo sapiens_hsa012120.58099375
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57865949
75Melanogenesis_Homo sapiens_hsa049160.57702648
76Metabolic pathways_Homo sapiens_hsa011000.57189821
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55899201
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55685338
79Tryptophan metabolism_Homo sapiens_hsa003800.55586547
80Gastric acid secretion_Homo sapiens_hsa049710.54548266
81Thyroid hormone synthesis_Homo sapiens_hsa049180.54046777
82Oxytocin signaling pathway_Homo sapiens_hsa049210.53517346
83cAMP signaling pathway_Homo sapiens_hsa040240.52912754
84Long-term potentiation_Homo sapiens_hsa047200.52593955
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51265737
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.50474062
87Chemical carcinogenesis_Homo sapiens_hsa052040.48432276
88Protein digestion and absorption_Homo sapiens_hsa049740.47738349
89Tyrosine metabolism_Homo sapiens_hsa003500.46766940
90Glutathione metabolism_Homo sapiens_hsa004800.46578036
91Spliceosome_Homo sapiens_hsa030400.45519621
92Calcium signaling pathway_Homo sapiens_hsa040200.44807441
93Fatty acid degradation_Homo sapiens_hsa000710.44716849
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.44368025
95RNA degradation_Homo sapiens_hsa030180.42803815
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41238524
97Sulfur metabolism_Homo sapiens_hsa009200.40416722
98Phenylalanine metabolism_Homo sapiens_hsa003600.40000985
99Purine metabolism_Homo sapiens_hsa002300.39937109
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38113222

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