TCEAL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.21777366
2synaptic vesicle maturation (GO:0016188)5.88186326
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.72670774
4vocalization behavior (GO:0071625)5.71974037
5synaptic vesicle exocytosis (GO:0016079)5.71655782
6locomotory exploration behavior (GO:0035641)5.56754990
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.51209811
8regulation of glutamate receptor signaling pathway (GO:1900449)5.21353706
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.15393605
10regulation of synaptic vesicle exocytosis (GO:2000300)5.15180608
11glutamate secretion (GO:0014047)5.13597333
12synaptic vesicle docking involved in exocytosis (GO:0016081)5.03211588
13protein localization to synapse (GO:0035418)4.84765614
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.71426487
15neuron cell-cell adhesion (GO:0007158)4.69601715
16neuronal action potential propagation (GO:0019227)4.67524988
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.64203999
18neurotransmitter secretion (GO:0007269)4.61773107
19regulation of synaptic vesicle transport (GO:1902803)4.58026490
20L-amino acid import (GO:0043092)4.57365114
21regulation of neuronal synaptic plasticity (GO:0048168)4.52486916
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.49926282
23cerebellar granule cell differentiation (GO:0021707)4.47042488
24central nervous system myelination (GO:0022010)4.42966612
25axon ensheathment in central nervous system (GO:0032291)4.42966612
26neurotransmitter-gated ion channel clustering (GO:0072578)4.39802334
27exploration behavior (GO:0035640)4.39551190
28potassium ion homeostasis (GO:0055075)4.32395818
29regulation of synapse structural plasticity (GO:0051823)4.31601593
30synaptic transmission, glutamatergic (GO:0035249)4.23976310
31glutamate receptor signaling pathway (GO:0007215)4.19382513
32neuron-neuron synaptic transmission (GO:0007270)4.19203472
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.06027895
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.02549367
35amino acid import (GO:0043090)3.96959291
36long-term memory (GO:0007616)3.96217051
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.94086621
38negative regulation of dendrite morphogenesis (GO:0050774)3.94063217
39layer formation in cerebral cortex (GO:0021819)3.90822853
40positive regulation of membrane potential (GO:0045838)3.89180487
41dendritic spine morphogenesis (GO:0060997)3.87916065
42potassium ion import (GO:0010107)3.86138898
43gamma-aminobutyric acid transport (GO:0015812)3.80124022
44long-term synaptic potentiation (GO:0060291)3.78640602
45neurotransmitter transport (GO:0006836)3.76431076
46regulation of postsynaptic membrane potential (GO:0060078)3.73480679
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.71675450
48regulation of synaptic plasticity (GO:0048167)3.71170217
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.70278290
50regulation of glutamate secretion (GO:0014048)3.69435431
51positive regulation of synapse maturation (GO:0090129)3.67973325
52gamma-aminobutyric acid signaling pathway (GO:0007214)3.67254577
53regulation of dendritic spine morphogenesis (GO:0061001)3.65784405
54detection of calcium ion (GO:0005513)3.65668895
55cellular potassium ion homeostasis (GO:0030007)3.61329662
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.61240610
57transmission of nerve impulse (GO:0019226)3.61055943
58regulation of synapse maturation (GO:0090128)3.60653239
59positive regulation of neurotransmitter transport (GO:0051590)3.60565443
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.58879225
61neuron recognition (GO:0008038)3.57705485
62positive regulation of dendritic spine morphogenesis (GO:0061003)3.57616854
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.56005420
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.55482878
65regulation of neurotransmitter levels (GO:0001505)3.52830095
66cellular sodium ion homeostasis (GO:0006883)3.52701210
67regulation of female receptivity (GO:0045924)3.52482156
68proline transport (GO:0015824)3.47777804
69positive regulation of neurotransmitter secretion (GO:0001956)3.47266289
70regulation of neurotransmitter secretion (GO:0046928)3.46567363
71prepulse inhibition (GO:0060134)3.45411718
72neuromuscular process controlling posture (GO:0050884)3.44825111
73auditory behavior (GO:0031223)3.44498684
74cell communication by electrical coupling (GO:0010644)3.40516249
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.39106604
76response to histamine (GO:0034776)3.39008473
77synaptic vesicle endocytosis (GO:0048488)3.38940426
78behavioral response to cocaine (GO:0048148)3.38786349
79activation of protein kinase A activity (GO:0034199)3.36190089
80regulation of vesicle fusion (GO:0031338)3.35502469
81neuromuscular process controlling balance (GO:0050885)3.35420154
82female mating behavior (GO:0060180)3.33153949
83neurotransmitter uptake (GO:0001504)3.32850378
84behavioral fear response (GO:0001662)3.31556406
85behavioral defense response (GO:0002209)3.31556406
86postsynaptic membrane organization (GO:0001941)3.30966357
87regulation of ARF protein signal transduction (GO:0032012)3.30274571
88presynaptic membrane assembly (GO:0097105)3.29614161
89regulation of neurotransmitter transport (GO:0051588)3.29380837
90membrane hyperpolarization (GO:0060081)3.26321396
91positive regulation of synaptic transmission (GO:0050806)3.25747620
92response to auditory stimulus (GO:0010996)3.25128200
93negative regulation of amino acid transport (GO:0051956)3.24675758
94cerebellar Purkinje cell differentiation (GO:0021702)3.24441655
95neuronal ion channel clustering (GO:0045161)3.24378940
96presynaptic membrane organization (GO:0097090)3.19644416
97membrane depolarization (GO:0051899)3.19032767
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17951607
99learning (GO:0007612)3.17944173
100establishment of synaptic vesicle localization (GO:0097480)3.16661371
101synaptic vesicle transport (GO:0048489)3.16661371
102axonal fasciculation (GO:0007413)3.16023488
103striatum development (GO:0021756)3.15536721
104synaptic transmission, dopaminergic (GO:0001963)3.13202210
105G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.12669255
106sodium ion export (GO:0071436)3.12162962
107regulation of synaptic transmission (GO:0050804)3.10941350
108regulation of dendritic spine development (GO:0060998)3.10419779
109neuromuscular synaptic transmission (GO:0007274)3.09381053
110fear response (GO:0042596)3.08914555
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.07629126
112serotonin metabolic process (GO:0042428)3.06493153
113synaptic transmission (GO:0007268)3.05738389
114regulation of synaptic transmission, GABAergic (GO:0032228)3.04867437
115regulation of cell communication by electrical coupling (GO:0010649)3.04667548
116cell differentiation in hindbrain (GO:0021533)3.02695091
117acidic amino acid transport (GO:0015800)3.02527459
118regulation of exocytosis (GO:0017157)3.02004584
119signal release (GO:0023061)3.01959214
120regulation of voltage-gated calcium channel activity (GO:1901385)3.01910860
121membrane depolarization during action potential (GO:0086010)3.01479242
122intraspecies interaction between organisms (GO:0051703)3.01364453
123social behavior (GO:0035176)3.01364453
124positive regulation of dendritic spine development (GO:0060999)3.00367497
125mating behavior (GO:0007617)2.95988158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.15087757
2GBX2_23144817_ChIP-Seq_PC3_Human3.66419209
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.28501609
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19021207
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.18973230
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.91554287
7REST_21632747_ChIP-Seq_MESCs_Mouse2.91243701
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80727694
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80727694
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77759096
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73363407
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62345211
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.62201987
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.60945963
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60379357
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59882940
17DROSHA_22980978_ChIP-Seq_HELA_Human2.51763065
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.42179031
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.38059430
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.36837557
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.34137730
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.32428050
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23392200
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.22431895
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20182128
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15868205
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08759636
28AR_21572438_ChIP-Seq_LNCaP_Human1.93903911
29TAF15_26573619_Chip-Seq_HEK293_Human1.93399054
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85642247
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82524978
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78539026
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73515543
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69746738
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.65788108
36SMAD4_21799915_ChIP-Seq_A2780_Human1.62888102
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55421277
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42107271
39P300_19829295_ChIP-Seq_ESCs_Human1.36601280
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36318436
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35565511
42RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34058436
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33920042
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33583837
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.33580045
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33517632
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31429199
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.29971635
49ZNF274_21170338_ChIP-Seq_K562_Hela1.28644777
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.28469854
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.27643025
52* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27583404
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23530473
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22169959
55AR_25329375_ChIP-Seq_VCAP_Human1.20171393
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19615532
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19407501
58AR_19668381_ChIP-Seq_PC3_Human1.15511118
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13652940
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13413636
61RNF2_27304074_Chip-Seq_NSC_Mouse1.12345222
62STAT3_23295773_ChIP-Seq_U87_Human1.12229157
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11962158
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11242046
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09447489
66TET1_21490601_ChIP-Seq_MESCs_Mouse1.08185725
67MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06810201
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.06318627
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.06043956
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.03582141
71TCF4_23295773_ChIP-Seq_U87_Human1.03561664
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03373415
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01982827
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01653836
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00510000
76ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99062394
77TP53_20018659_ChIP-ChIP_R1E_Mouse0.96808233
78PRDM14_20953172_ChIP-Seq_ESCs_Human0.95801151
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95485639
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95424551
81RUNX2_22187159_ChIP-Seq_PCA_Human0.95066608
82YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95062464
83FUS_26573619_Chip-Seq_HEK293_Human0.94388760
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94245374
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93722254
86ARNT_22903824_ChIP-Seq_MCF-7_Human0.93505510
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93390833
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93300622
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.93208559
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92994869
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92650634
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92188418
93JUN_21703547_ChIP-Seq_K562_Human0.91157685
94AHR_22903824_ChIP-Seq_MCF-7_Human0.90255979
95IGF1R_20145208_ChIP-Seq_DFB_Human0.89338432
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89203189
97KDM2B_26808549_Chip-Seq_K562_Human0.89181267
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87915652
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.87154986
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86501134
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86354394
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85591211
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85347936
104CTCF_27219007_Chip-Seq_Bcells_Human0.85115711
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.84549278
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84254885
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83826974
108ER_23166858_ChIP-Seq_MCF-7_Human0.83380209
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.83380138
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83339755
111VDR_22108803_ChIP-Seq_LS180_Human0.83027536
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81145131
113OCT4_19829295_ChIP-Seq_ESCs_Human0.79689106
114DPY_21335234_ChIP-Seq_ESCs_Mouse0.78999797
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78511905
116ESR2_21235772_ChIP-Seq_MCF-7_Human0.78180698
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76169979
118SOX9_26525672_Chip-Seq_HEART_Mouse0.76049911
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75955513
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75616230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.42822345
2MP0003880_abnormal_central_pattern5.17728234
3MP0003635_abnormal_synaptic_transmissio4.23324082
4MP0002822_catalepsy3.69123831
5MP0009745_abnormal_behavioral_response3.60117449
6MP0004270_analgesia3.45172240
7MP0002063_abnormal_learning/memory/cond3.44015875
8MP0002064_seizures3.34361943
9MP0009046_muscle_twitch3.20177264
10MP0001968_abnormal_touch/_nociception3.03134941
11MP0002572_abnormal_emotion/affect_behav2.92680629
12MP0005423_abnormal_somatic_nervous2.83284946
13MP0002272_abnormal_nervous_system2.74845930
14MP0001486_abnormal_startle_reflex2.61786488
15MP0002734_abnormal_mechanical_nocicepti2.50321738
16MP0001501_abnormal_sleep_pattern2.43653085
17MP0002736_abnormal_nociception_after2.35875515
18MP0001440_abnormal_grooming_behavior2.19498386
19MP0002735_abnormal_chemical_nociception1.99699212
20MP0002067_abnormal_sensory_capabilities1.93582150
21MP0001970_abnormal_pain_threshold1.92822125
22MP0002733_abnormal_thermal_nociception1.91347330
23MP0005646_abnormal_pituitary_gland1.87129056
24MP0001529_abnormal_vocalization1.87067482
25MP0009780_abnormal_chondrocyte_physiolo1.83570001
26MP0008569_lethality_at_weaning1.82122101
27MP0004924_abnormal_behavior1.78992783
28MP0005386_behavior/neurological_phenoty1.78992783
29MP0002557_abnormal_social/conspecific_i1.78133404
30MP0006276_abnormal_autonomic_nervous1.73873673
31MP0004811_abnormal_neuron_physiology1.71437276
32MP0003122_maternal_imprinting1.70414189
33MP0003787_abnormal_imprinting1.69719689
34MP0002184_abnormal_innervation1.67089286
35MP0003329_amyloid_beta_deposits1.66557075
36MP0002909_abnormal_adrenal_gland1.64616594
37MP0003879_abnormal_hair_cell1.63418570
38MP0001984_abnormal_olfaction1.60994808
39MP0000778_abnormal_nervous_system1.59193958
40MP0001905_abnormal_dopamine_level1.50468798
41MP0000955_abnormal_spinal_cord1.43813053
42MP0002066_abnormal_motor_capabilities/c1.42469911
43MP0005645_abnormal_hypothalamus_physiol1.40863756
44MP0004142_abnormal_muscle_tone1.38454132
45MP0002882_abnormal_neuron_morphology1.38288681
46MP0004858_abnormal_nervous_system1.37337134
47MP0001502_abnormal_circadian_rhythm1.36300080
48MP0004885_abnormal_endolymph1.35346411
49MP0003633_abnormal_nervous_system1.29651458
50MP0001188_hyperpigmentation1.28349123
51MP0008877_abnormal_DNA_methylation1.24496142
52MP0000751_myopathy1.15702727
53MP0003631_nervous_system_phenotype1.09867564
54MP0008872_abnormal_physiological_respon1.08765817
55MP0002152_abnormal_brain_morphology1.04979074
56MP0005551_abnormal_eye_electrophysiolog1.01298011
57MP0002069_abnormal_eating/drinking_beha0.99024565
58MP0002229_neurodegeneration0.98249951
59MP0000013_abnormal_adipose_tissue0.96627648
60MP0008874_decreased_physiological_sensi0.95148095
61MP0004742_abnormal_vestibular_system0.93425301
62MP0005535_abnormal_body_temperature0.90637574
63MP0003075_altered_response_to0.90549607
64MP0004147_increased_porphyrin_level0.89470351
65MP0003690_abnormal_glial_cell0.88375228
66MP0002837_dystrophic_cardiac_calcinosis0.88230787
67MP0001986_abnormal_taste_sensitivity0.86274029
68MP0005394_taste/olfaction_phenotype0.84342780
69MP0005499_abnormal_olfactory_system0.84342780
70MP0004085_abnormal_heartbeat0.83945018
71MP0001177_atelectasis0.83826180
72MP0004145_abnormal_muscle_electrophysio0.83664360
73MP0001963_abnormal_hearing_physiology0.82565794
74MP0008961_abnormal_basal_metabolism0.78513048
75MP0003634_abnormal_glial_cell0.78454762
76MP0002090_abnormal_vision0.78340362
77MP0000631_abnormal_neuroendocrine_gland0.78323750
78MP0000920_abnormal_myelination0.77699506
79MP0000566_synostosis0.75167711
80MP0002752_abnormal_somatic_nervous0.74214835
81MP0003632_abnormal_nervous_system0.74092807
82MP0002876_abnormal_thyroid_physiology0.73925473
83MP0010386_abnormal_urinary_bladder0.72394359
84MP0004510_myositis0.72319997
85MP0001485_abnormal_pinna_reflex0.71741930
86MP0000604_amyloidosis0.68559131
87MP0001664_abnormal_digestion0.67751385
88MP0003283_abnormal_digestive_organ0.66711201
89MP0005409_darkened_coat_color0.66604462
90MP0004215_abnormal_myocardial_fiber0.66508194
91MP0005167_abnormal_blood-brain_barrier0.65761220
92MP0000026_abnormal_inner_ear0.64657291
93MP0003137_abnormal_impulse_conducting0.63783015
94MP0003121_genomic_imprinting0.61937352
95MP0003123_paternal_imprinting0.61180202
96MP0004484_altered_response_of0.60630384
97MP0004233_abnormal_muscle_weight0.59106621
98MP0001346_abnormal_lacrimal_gland0.58627956
99MP0005623_abnormal_meninges_morphology0.57098830
100MP0001943_abnormal_respiration0.56442608
101MP0000639_abnormal_adrenal_gland0.54334018
102MP0004043_abnormal_pH_regulation0.53636236
103MP0006072_abnormal_retinal_apoptosis0.51348960
104MP0010768_mortality/aging0.51104509
105MP0002638_abnormal_pupillary_reflex0.50004445
106MP0003956_abnormal_body_size0.49609744
107MP0010769_abnormal_survival0.49347995
108MP0001765_abnormal_ion_homeostasis0.48296204
109MP0010770_preweaning_lethality0.48058488
110MP0002082_postnatal_lethality0.48058488
111MP0003938_abnormal_ear_development0.46994343
112MP0005166_decreased_susceptibility_to0.45636465
113MP0000569_abnormal_digit_pigmentation0.45419738
114MP0001299_abnormal_eye_distance/0.44355385

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.27505255
2Myokymia (HP:0002411)7.43935553
3Focal seizures (HP:0007359)5.97895585
4Visual hallucinations (HP:0002367)5.30596225
5Atonic seizures (HP:0010819)5.21591689
6Epileptic encephalopathy (HP:0200134)5.08508707
7Febrile seizures (HP:0002373)4.76734089
8Absence seizures (HP:0002121)4.57097501
9Dialeptic seizures (HP:0011146)4.15990020
10Generalized tonic-clonic seizures (HP:0002069)4.15177242
11Progressive cerebellar ataxia (HP:0002073)4.09038389
12Cerebral hypomyelination (HP:0006808)3.67720372
13Action tremor (HP:0002345)3.61284013
14Broad-based gait (HP:0002136)3.57163865
15Ankle clonus (HP:0011448)3.47191777
16Hyperventilation (HP:0002883)3.42259605
17Impaired vibration sensation in the lower limbs (HP:0002166)3.37852918
18Poor eye contact (HP:0000817)3.33463008
19Supranuclear gaze palsy (HP:0000605)3.33240829
20Anxiety (HP:0000739)3.32901032
21Abnormal eating behavior (HP:0100738)3.28631999
22Depression (HP:0000716)3.27760467
23Dysdiadochokinesis (HP:0002075)3.24059565
24Gaze-evoked nystagmus (HP:0000640)3.18086173
25Abnormal social behavior (HP:0012433)3.07697749
26Impaired social interactions (HP:0000735)3.07697749
27Dysmetria (HP:0001310)3.07160707
28Amblyopia (HP:0000646)3.00273100
29Truncal ataxia (HP:0002078)2.99048034
30Urinary bladder sphincter dysfunction (HP:0002839)2.91862190
31Progressive inability to walk (HP:0002505)2.88759411
32Abnormality of the lower motor neuron (HP:0002366)2.88096649
33Mutism (HP:0002300)2.86213397
34Obstructive sleep apnea (HP:0002870)2.85922594
35Postural instability (HP:0002172)2.84176574
36Torticollis (HP:0000473)2.79573263
37Tetraplegia (HP:0002445)2.79504140
38Increased circulating renin level (HP:0000848)2.69902009
39Focal dystonia (HP:0004373)2.69420167
40Urinary urgency (HP:0000012)2.62125145
41Polyphagia (HP:0002591)2.56438682
42Scanning speech (HP:0002168)2.55991159
43Spastic gait (HP:0002064)2.54279521
44Epileptiform EEG discharges (HP:0011182)2.53574443
45Limb dystonia (HP:0002451)2.51988915
46Hemiparesis (HP:0001269)2.51002838
47Akinesia (HP:0002304)2.48746166
48Bradykinesia (HP:0002067)2.48048522
49Drooling (HP:0002307)2.45050145
50Excessive salivation (HP:0003781)2.45050145
51Impaired smooth pursuit (HP:0007772)2.43009619
52Pheochromocytoma (HP:0002666)2.42938513
53Papilledema (HP:0001085)2.42442014
54EEG with generalized epileptiform discharges (HP:0011198)2.40912100
55Apathy (HP:0000741)2.39500179
56Craniofacial dystonia (HP:0012179)2.39032460
57Peripheral hypomyelination (HP:0007182)2.38689852
58Status epilepticus (HP:0002133)2.38117208
59Stereotypic behavior (HP:0000733)2.37423937
60Abnormality of binocular vision (HP:0011514)2.37285910
61Diplopia (HP:0000651)2.37285910
62Degeneration of the lateral corticospinal tracts (HP:0002314)2.35371935
63Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.35371935
64Hemiplegia (HP:0002301)2.34639936
65Annular pancreas (HP:0001734)2.32801922
66Cerebral inclusion bodies (HP:0100314)2.31831425
67Intention tremor (HP:0002080)2.31802710
68Ventricular fibrillation (HP:0001663)2.27149756
69Hypsarrhythmia (HP:0002521)2.26842253
70Choreoathetosis (HP:0001266)2.25119590
71Genetic anticipation (HP:0003743)2.23998539
72Spastic tetraparesis (HP:0001285)2.23560597
73Neurofibrillary tangles (HP:0002185)2.21760656
74Generalized myoclonic seizures (HP:0002123)2.21641756
75Dysmetric saccades (HP:0000641)2.20858632
76Diminished motivation (HP:0000745)2.18024773
77Impaired vibratory sensation (HP:0002495)2.17835391
78Resting tremor (HP:0002322)2.17703562
79Inability to walk (HP:0002540)2.17593562
80Neuroendocrine neoplasm (HP:0100634)2.17215832
81Megalencephaly (HP:0001355)2.16525566
82Gait imbalance (HP:0002141)2.14981092
83Fetal akinesia sequence (HP:0001989)2.14825742
84Abnormality of ocular smooth pursuit (HP:0000617)2.13609694
85Delusions (HP:0000746)2.13272556
86Lower limb muscle weakness (HP:0007340)2.10697372
87Failure to thrive in infancy (HP:0001531)2.09814432
88CNS hypomyelination (HP:0003429)2.09085682
89Bundle branch block (HP:0011710)2.09055885
90Incomplete penetrance (HP:0003829)2.08526556
91Absent speech (HP:0001344)2.07152458
92Specific learning disability (HP:0001328)2.03299537
93Abnormality of the corticospinal tract (HP:0002492)2.01456232
94Morphological abnormality of the pyramidal tract (HP:0002062)2.01401717
95Psychosis (HP:0000709)1.99744493
96Hypoventilation (HP:0002791)1.97039951
97Insidious onset (HP:0003587)1.96948433
98Termporal pattern (HP:0011008)1.96948433
99Neuronal loss in central nervous system (HP:0002529)1.93471962
100Slow saccadic eye movements (HP:0000514)1.87995965
101Pointed chin (HP:0000307)1.86764203
102Gait ataxia (HP:0002066)1.85269038
103Abnormal EKG (HP:0003115)1.85071201
104Clonus (HP:0002169)1.83306361
105Poor suck (HP:0002033)1.82936115
106Congenital primary aphakia (HP:0007707)1.82629895
107Insomnia (HP:0100785)1.81355848
108Abnormal hair whorl (HP:0010721)1.81236102
109Sleep apnea (HP:0010535)1.80977355
110Prolonged QT interval (HP:0001657)1.80358376
111Blue irides (HP:0000635)1.80153341
112Memory impairment (HP:0002354)1.79576388
113Rigidity (HP:0002063)1.79054911
114Split foot (HP:0001839)1.77462024
115Abnormality of saccadic eye movements (HP:0000570)1.76205649
116Rapidly progressive (HP:0003678)1.72972490
117Unsteady gait (HP:0002317)1.72506346
118Medial flaring of the eyebrow (HP:0010747)1.72349801
119Generalized hypotonia (HP:0001290)1.71921944
120Narrow nasal bridge (HP:0000446)1.71843463
121Lower limb asymmetry (HP:0100559)1.71799398
122Limb ataxia (HP:0002070)1.70120665
123Dysarthria (HP:0001260)1.67056290
124Syncope (HP:0001279)1.66690875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.95229932
2NTRK34.40061398
3MAP3K93.72298046
4MAP3K43.04845128
5MAP2K72.60177981
6MINK12.58104058
7DAPK22.57839737
8MAP3K122.51921411
9MARK12.36336306
10CASK2.33587701
11NTRK22.07898216
12KSR22.07618230
13PAK62.06086269
14ARAF1.95248383
15RIPK41.92632091
16MAP2K41.91450820
17CDK191.77354196
18DAPK11.76554007
19PRKD31.74591263
20CAMKK11.71907855
21PLK21.65108738
22KSR11.62259149
23PNCK1.55334344
24CDK51.54762591
25GRK51.52930789
26MAP3K131.50117616
27FES1.47845879
28PRPF4B1.41685056
29NTRK11.41008508
30TNIK1.26395574
31PRKCG1.25586628
32STK381.25565882
33MAPK131.19297680
34UHMK11.19002846
35SIK21.18143887
36CAMKK21.07364505
37CAMK2A1.04749771
38TYRO31.03707190
39OXSR11.01789478
40SGK2230.98777938
41SGK4940.98777938
42CDK180.97494267
43MAP3K20.97009537
44IRAK20.96336744
45PTK2B0.95159441
46CDK150.94697442
47CAMK10.94279731
48CDK140.91978859
49CAMK2B0.91784501
50TAOK10.90897088
51MAPK120.89742475
52NME10.87737209
53RAF10.86655573
54CDK11A0.83787532
55PINK10.82438529
56BMPR20.80377632
57PRKCH0.80332324
58STK110.80313906
59PHKG20.79751946
60PHKG10.79751946
61SGK20.75093222
62TNK20.74003201
63PKN10.73187040
64DYRK1A0.66606436
65SGK10.65384009
66BRAF0.63056713
67LATS20.61763964
68PDPK10.61655601
69PDK10.61261020
70FGFR20.60313021
71RIPK10.60288761
72PAK30.59913789
73MAP3K10.58963710
74SGK30.58725251
75CCNB10.56253777
76RET0.56093714
77LIMK10.55547640
78BRSK10.55108282
79ALK0.54184217
80DAPK30.54142976
81CAMK2D0.53225405
82LMTK20.52902514
83AKT30.52089159
84CAMK2G0.51994524
85CSNK1G20.51425907
86MAP3K110.51220005
87PRKCE0.50775025
88FGR0.50253811
89MARK20.48844732
90NEK10.48779001
91RPS6KA30.46600419
92CAMK1G0.45690037
93NEK60.45203208
94TSSK60.44458049
95PRKCA0.44414204
96PRKCZ0.44282947
97CAMK40.43707952
98SIK30.42299085
99STK390.42144075
100FYN0.41025861
101MUSK0.40028914
102MAP2K10.39326003
103FER0.38760628
104DMPK0.38483583
105MAPK100.38122504
106PRKG10.37948365
107WNK10.37252408
108WNK30.37151459
109MOS0.36808810
110ROCK20.35640578
111MAPKAPK50.35327741
112MAP2K60.35166348
113BCR0.34502616
114PRKACA0.34378819
115GRK70.34114901
116CSNK1E0.33087522
117CDC42BPA0.32807754
118PRKCB0.28430428

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.90770942
2Synaptic vesicle cycle_Homo sapiens_hsa047213.69295057
3Olfactory transduction_Homo sapiens_hsa047402.97736042
4GABAergic synapse_Homo sapiens_hsa047272.86025709
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72544947
6Circadian entrainment_Homo sapiens_hsa047132.70359333
7Long-term potentiation_Homo sapiens_hsa047202.67712900
8Morphine addiction_Homo sapiens_hsa050322.62441263
9Amphetamine addiction_Homo sapiens_hsa050312.58345946
10Glutamatergic synapse_Homo sapiens_hsa047242.54959223
11Dopaminergic synapse_Homo sapiens_hsa047282.20893553
12Salivary secretion_Homo sapiens_hsa049702.15166594
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12183901
14Collecting duct acid secretion_Homo sapiens_hsa049662.09074912
15Insulin secretion_Homo sapiens_hsa049111.95503602
16Cholinergic synapse_Homo sapiens_hsa047251.86008116
17Gastric acid secretion_Homo sapiens_hsa049711.85636220
18Cocaine addiction_Homo sapiens_hsa050301.78984224
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76626725
20Renin secretion_Homo sapiens_hsa049241.74308399
21Taste transduction_Homo sapiens_hsa047421.74225496
22Serotonergic synapse_Homo sapiens_hsa047261.68693044
23Long-term depression_Homo sapiens_hsa047301.68546197
24Oxytocin signaling pathway_Homo sapiens_hsa049211.67126459
25Calcium signaling pathway_Homo sapiens_hsa040201.62553046
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61711988
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49247582
28GnRH signaling pathway_Homo sapiens_hsa049121.39915008
29Vitamin B6 metabolism_Homo sapiens_hsa007501.37589720
30Gap junction_Homo sapiens_hsa045401.31532174
31Cardiac muscle contraction_Homo sapiens_hsa042601.30631508
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28697028
33Vibrio cholerae infection_Homo sapiens_hsa051101.26363193
34cAMP signaling pathway_Homo sapiens_hsa040241.21777517
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20489914
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13599971
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13130357
38Oxidative phosphorylation_Homo sapiens_hsa001901.03877359
39Phototransduction_Homo sapiens_hsa047441.03081326
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02263917
41Glioma_Homo sapiens_hsa052141.00905680
42Estrogen signaling pathway_Homo sapiens_hsa049151.00593528
43Type II diabetes mellitus_Homo sapiens_hsa049300.98496406
44Axon guidance_Homo sapiens_hsa043600.97780953
45Melanogenesis_Homo sapiens_hsa049160.96962613
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96496586
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94918680
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94733683
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92578846
50Nitrogen metabolism_Homo sapiens_hsa009100.91057156
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.90748791
52ErbB signaling pathway_Homo sapiens_hsa040120.90716365
53Alzheimers disease_Homo sapiens_hsa050100.90277878
54Parkinsons disease_Homo sapiens_hsa050120.85162480
55Oocyte meiosis_Homo sapiens_hsa041140.83887950
56Pancreatic secretion_Homo sapiens_hsa049720.73781083
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71090796
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.70160879
59Dorso-ventral axis formation_Homo sapiens_hsa043200.69627256
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67665190
61Thyroid hormone synthesis_Homo sapiens_hsa049180.67072659
62Type I diabetes mellitus_Homo sapiens_hsa049400.66861558
63Dilated cardiomyopathy_Homo sapiens_hsa054140.66631456
64MAPK signaling pathway_Homo sapiens_hsa040100.65567190
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64412819
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59952037
67Glucagon signaling pathway_Homo sapiens_hsa049220.56424737
68Choline metabolism in cancer_Homo sapiens_hsa052310.56375468
69Alcoholism_Homo sapiens_hsa050340.56009901
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52754018
71Mineral absorption_Homo sapiens_hsa049780.51188380
72Ras signaling pathway_Homo sapiens_hsa040140.50851131
73Huntingtons disease_Homo sapiens_hsa050160.50470528
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49130013
75VEGF signaling pathway_Homo sapiens_hsa043700.48817773
76Histidine metabolism_Homo sapiens_hsa003400.48693709
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.47965550
78Rap1 signaling pathway_Homo sapiens_hsa040150.46360505
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44819231
80Prion diseases_Homo sapiens_hsa050200.43676317
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42966265
82Arginine and proline metabolism_Homo sapiens_hsa003300.42743285
83Inositol phosphate metabolism_Homo sapiens_hsa005620.41691300
84Endocytosis_Homo sapiens_hsa041440.41415157
85Circadian rhythm_Homo sapiens_hsa047100.41022818
86Rheumatoid arthritis_Homo sapiens_hsa053230.40307851
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.40274066
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39664548
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38337115
90Bile secretion_Homo sapiens_hsa049760.37984041
91Arginine biosynthesis_Homo sapiens_hsa002200.36754935
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36064428
93Regulation of autophagy_Homo sapiens_hsa041400.35501642
94African trypanosomiasis_Homo sapiens_hsa051430.33800082
95Non-small cell lung cancer_Homo sapiens_hsa052230.33627499
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33330786
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33127386
98Renal cell carcinoma_Homo sapiens_hsa052110.31163120
99Wnt signaling pathway_Homo sapiens_hsa043100.30847568
100mTOR signaling pathway_Homo sapiens_hsa041500.30824912
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29002710
102Insulin signaling pathway_Homo sapiens_hsa049100.28919428
103Ovarian steroidogenesis_Homo sapiens_hsa049130.27944382
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26941339
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25985527
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25931011
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25847448
108beta-Alanine metabolism_Homo sapiens_hsa004100.25585749
109Fatty acid biosynthesis_Homo sapiens_hsa000610.22972763
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20534847
111Folate biosynthesis_Homo sapiens_hsa007900.14900547

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