TCEAL7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)9.17243150
2sarcoplasmic reticulum calcium ion transport (GO:0070296)9.11239828
3plasma membrane repair (GO:0001778)7.97847267
4actin filament-based movement (GO:0030048)7.62641449
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.34214858
6skeletal muscle fiber development (GO:0048741)6.68452458
7striated muscle contraction (GO:0006941)6.28732730
8myotube cell development (GO:0014904)6.14317497
9negative regulation of potassium ion transmembrane transport (GO:1901380)6.01170192
10pyrimidine nucleobase catabolic process (GO:0006208)5.87779920
11regulation of relaxation of muscle (GO:1901077)5.57156214
12sarcomere organization (GO:0045214)5.55650733
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.47303741
14regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.31506941
15regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.13360790
16regulation of cell communication by electrical coupling (GO:0010649)5.11321493
17myofibril assembly (GO:0030239)4.99251213
18skeletal muscle adaptation (GO:0043501)4.94655005
19muscle contraction (GO:0006936)4.88036910
20muscle cell cellular homeostasis (GO:0046716)4.86089379
21presynaptic membrane assembly (GO:0097105)4.65759268
22nucleobase catabolic process (GO:0046113)4.65058477
23response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.48625393
24postsynaptic membrane organization (GO:0001941)4.45805846
25presynaptic membrane organization (GO:0097090)4.44489435
26response to inactivity (GO:0014854)4.42826441
27neuron cell-cell adhesion (GO:0007158)4.42781004
28axonal fasciculation (GO:0007413)4.37843417
29sequestering of actin monomers (GO:0042989)4.35606706
30muscle fiber development (GO:0048747)4.33128686
31muscle system process (GO:0003012)4.29260661
32negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.26897036
33neuron recognition (GO:0008038)4.19190914
34vocalization behavior (GO:0071625)4.16331571
35protein localization to synapse (GO:0035418)4.15039758
36regulation of calcium ion transmembrane transporter activity (GO:1901019)4.08785905
37regulation of calcium ion transmembrane transport (GO:1903169)4.08785905
38glycogen catabolic process (GO:0005980)4.03992078
39auditory behavior (GO:0031223)4.03468781
40skeletal muscle tissue regeneration (GO:0043403)3.98183048
41regulation of sarcomere organization (GO:0060297)3.96291480
42neurotransmitter-gated ion channel clustering (GO:0072578)3.95878912
43actomyosin structure organization (GO:0031032)3.94862745
44myoblast fusion (GO:0007520)3.94678931
45negative regulation of protein localization to cell surface (GO:2000009)3.93395609
46behavioral response to nicotine (GO:0035095)3.92752637
47regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.91009979
48muscle organ development (GO:0007517)3.88666659
49positive regulation of myotube differentiation (GO:0010831)3.83888166
50negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.82257164
51gamma-aminobutyric acid transport (GO:0015812)3.80966130
52muscle structure development (GO:0061061)3.80489195
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.79603723
54short-term memory (GO:0007614)3.79253394
55negative regulation of potassium ion transport (GO:0043267)3.78409424
56regulation of acyl-CoA biosynthetic process (GO:0050812)3.75757217
57glucan catabolic process (GO:0009251)3.75146285
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.74274520
59transmission of nerve impulse (GO:0019226)3.72980980
60cardiac muscle contraction (GO:0060048)3.71315606
61dendritic spine morphogenesis (GO:0060997)3.70713664
62ionotropic glutamate receptor signaling pathway (GO:0035235)3.70463965
63retinal ganglion cell axon guidance (GO:0031290)3.66855259
64response to muscle activity (GO:0014850)3.60564227
65regulation of synapse structural plasticity (GO:0051823)3.60312737
66positive regulation of myoblast differentiation (GO:0045663)3.59213557
67cardiac myofibril assembly (GO:0055003)3.58793752
68synapse assembly (GO:0007416)3.57198889
69neuromuscular synaptic transmission (GO:0007274)3.49770308
70regulation of membrane repolarization (GO:0060306)3.48264849
71establishment of mitochondrion localization (GO:0051654)3.48184545
72negative regulation of calcium ion transmembrane transport (GO:1903170)3.45921663
73negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.45921663
74regulation of coenzyme metabolic process (GO:0051196)3.45626286
75regulation of cofactor metabolic process (GO:0051193)3.45626286
76striated muscle atrophy (GO:0014891)3.45487409
77regulation of striated muscle contraction (GO:0006942)3.44772255
78regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.41113615
79regulation of potassium ion transmembrane transporter activity (GO:1901016)3.40999007
80muscle cell fate commitment (GO:0042693)3.40877710
81cellular polysaccharide catabolic process (GO:0044247)3.40746295
82striated muscle cell development (GO:0055002)3.39758706
83regulation of short-term neuronal synaptic plasticity (GO:0048172)3.39580818
84syncytium formation by plasma membrane fusion (GO:0000768)3.37394668
85regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.37383436
86neuron fate determination (GO:0048664)3.37364691
87ATP synthesis coupled proton transport (GO:0015986)3.36462012
88energy coupled proton transport, down electrochemical gradient (GO:0015985)3.36462012
89skeletal muscle tissue development (GO:0007519)3.36312302
90mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36233335
91negative regulation of muscle hypertrophy (GO:0014741)3.35787496
92protein localization to cilium (GO:0061512)3.35156257
93negative regulation of synaptic transmission, GABAergic (GO:0032229)3.34307505
94neurofilament cytoskeleton organization (GO:0060052)3.33075039
95neuromuscular junction development (GO:0007528)3.33060441
96regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.31601967
97striated muscle adaptation (GO:0014888)3.30648361
98neuronal action potential propagation (GO:0019227)3.28967608
99positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.26403721
100myotube differentiation (GO:0014902)3.26353946
101regulation of feeding behavior (GO:0060259)3.26137405
102synaptic transmission, glutamatergic (GO:0035249)3.25658679
103regulation of skeletal muscle cell differentiation (GO:2001014)3.25229869
104negative regulation of axon guidance (GO:1902668)3.24200006
105cell migration in hindbrain (GO:0021535)3.23508581
106syncytium formation (GO:0006949)3.21484254
107glutamate receptor signaling pathway (GO:0007215)3.21456889
108regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.20920845
109polysaccharide catabolic process (GO:0000272)3.18158060
110mechanosensory behavior (GO:0007638)3.16120591
111cytidine deamination (GO:0009972)3.15729504
112cytidine metabolic process (GO:0046087)3.15729504
113cytidine catabolic process (GO:0006216)3.15729504
114creatine metabolic process (GO:0006600)3.14061479
115response to auditory stimulus (GO:0010996)3.10168136
116negative regulation of norepinephrine secretion (GO:0010700)3.10132845
117positive regulation of synapse assembly (GO:0051965)3.10118103
118synaptic vesicle maturation (GO:0016188)3.08392384
119neuronal ion channel clustering (GO:0045161)3.08105904
120positive regulation of dendritic spine morphogenesis (GO:0061003)3.07503263
121regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.06923835
122synaptic vesicle exocytosis (GO:0016079)3.05474296
123negative regulation of ion transmembrane transporter activity (GO:0032413)3.05179748
124exploration behavior (GO:0035640)3.04439746
125limb bud formation (GO:0060174)3.04120456
126calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.02595526
127nonmotile primary cilium assembly (GO:0035058)3.01393403
128regulation of potassium ion transmembrane transport (GO:1901379)2.99628185
129positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.99187713
130membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.99116236
131regulation of synaptic vesicle exocytosis (GO:2000300)2.98023926
132pyrimidine ribonucleoside catabolic process (GO:0046133)2.96033039
133respiratory electron transport chain (GO:0022904)2.95779765
134neuron-neuron synaptic transmission (GO:0007270)2.95579044
135head development (GO:0060322)2.95115287
136muscle atrophy (GO:0014889)2.94840078
137epithelial cilium movement (GO:0003351)2.94561348
138glutamate secretion (GO:0014047)2.93929655
139regulation of synaptic transmission, glutamatergic (GO:0051966)2.93110668
140muscle cell development (GO:0055001)2.91760809
141positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.90420357
142synapse organization (GO:0050808)2.88633147
143glycogen biosynthetic process (GO:0005978)2.87844510
144glucan biosynthetic process (GO:0009250)2.87844510
145central nervous system projection neuron axonogenesis (GO:0021952)2.87339161
146positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.87087563
147locomotory exploration behavior (GO:0035641)2.86885383
148electron transport chain (GO:0022900)2.86497498
149adult walking behavior (GO:0007628)2.85831062
150detection of calcium ion (GO:0005513)2.85785493
151dendrite morphogenesis (GO:0048813)2.85254785
152cochlea development (GO:0090102)2.84773797
153positive regulation of mitochondrial fission (GO:0090141)2.82843890
154startle response (GO:0001964)2.81558449
155regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81337508
156spinal cord development (GO:0021510)2.81154259
157carnitine shuttle (GO:0006853)2.80997576
158negative regulation of cell size (GO:0045792)2.80588645
159G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.80278203
160regulation of muscle system process (GO:0090257)2.76467875
161neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.75355311
162neurotransmitter secretion (GO:0007269)2.74996512
163protein polyglutamylation (GO:0018095)2.74994268
164somite development (GO:0061053)2.74254789
165epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.74210601
166regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73453756
167cerebral cortex radially oriented cell migration (GO:0021799)2.72629143
168establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.70804818
169mitochondrion transport along microtubule (GO:0047497)2.70804818
170tricarboxylic acid cycle (GO:0006099)2.69880863
171behavioral response to ethanol (GO:0048149)2.68476168
172gamma-aminobutyric acid signaling pathway (GO:0007214)2.68005306
173axon extension (GO:0048675)2.67433606
174neuronal action potential (GO:0019228)2.65511766
175regulation of synaptic transmission, GABAergic (GO:0032228)2.64252291
176negative regulation of axonogenesis (GO:0050771)2.63721115
177intraciliary transport (GO:0042073)2.63710698
178axon ensheathment in central nervous system (GO:0032291)2.63132846
179central nervous system myelination (GO:0022010)2.63132846
180positive regulation of amino acid transport (GO:0051957)2.62077199
181regulation of synaptic vesicle transport (GO:1902803)2.60921056
182substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.59897497
183substrate-independent telencephalic tangential migration (GO:0021826)2.59897497
184epithelial cell differentiation involved in kidney development (GO:0035850)2.59413804
185negative regulation of axon extension (GO:0030517)2.57918417
186synaptic transmission, cholinergic (GO:0007271)2.56792049
187regulation of axon guidance (GO:1902667)2.56377686
188glycosphingolipid biosynthetic process (GO:0006688)2.56301039
189negative regulation of microtubule polymerization (GO:0031115)2.55252914
190cytoskeleton-dependent intracellular transport (GO:0030705)2.55132038
191dendrite development (GO:0016358)2.55064637
192heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.54362136
193negative regulation of telomere maintenance (GO:0032205)2.53980150
194regulation of synapse assembly (GO:0051963)2.53261214
195actin-myosin filament sliding (GO:0033275)12.7025067
196muscle filament sliding (GO:0030049)12.7025067
197skeletal muscle contraction (GO:0003009)11.0772013
198actin-mediated cell contraction (GO:0070252)10.3495757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39833188
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.04791559
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.62723124
4GBX2_23144817_ChIP-Seq_PC3_Human3.50423360
5ZNF274_21170338_ChIP-Seq_K562_Hela3.05624391
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67666502
7TAF15_26573619_Chip-Seq_HEK293_Human2.64631684
8IGF1R_20145208_ChIP-Seq_DFB_Human2.53735977
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52632318
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51284872
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39483567
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39483567
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.29717631
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.29458266
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28023197
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18974766
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10622291
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08759947
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02564154
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98015688
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.97381987
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.91614372
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86695118
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.85403722
25FUS_26573619_Chip-Seq_HEK293_Human1.83858337
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80980614
27DROSHA_22980978_ChIP-Seq_HELA_Human1.80333858
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79785701
29EWS_26573619_Chip-Seq_HEK293_Human1.79704377
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72645501
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.70711547
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69747132
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68479423
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.68005379
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66865152
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.62600733
37VDR_22108803_ChIP-Seq_LS180_Human1.60614186
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55115193
39AR_21572438_ChIP-Seq_LNCaP_Human1.53209159
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.51891281
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.49948625
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.49162292
43REST_21632747_ChIP-Seq_MESCs_Mouse1.46261321
44SMAD4_21799915_ChIP-Seq_A2780_Human1.45765819
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45416714
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.44718174
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44472164
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40955150
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40726389
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37565051
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37565051
52CBP_20019798_ChIP-Seq_JUKART_Human1.37256561
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37256561
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36440862
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35439159
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35349964
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33755187
58ZNF263_19887448_ChIP-Seq_K562_Human1.32248471
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30767257
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30386826
61P300_19829295_ChIP-Seq_ESCs_Human1.28657556
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.28187483
63* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26883242
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25330960
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23631530
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22528906
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.22473645
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21553850
69AR_25329375_ChIP-Seq_VCAP_Human1.20078546
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.19599451
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18564765
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17851929
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17758681
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17291014
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.17263709
76WT1_19549856_ChIP-ChIP_CCG9911_Human1.16546063
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.16463948
78STAT3_23295773_ChIP-Seq_U87_Human1.16318870
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16270601
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15630211
81RUNX2_22187159_ChIP-Seq_PCA_Human1.14290508
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.12599532
83TP53_16413492_ChIP-PET_HCT116_Human1.12328325
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11503326
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09983996
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.09963072
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09877050
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09623669
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09273979
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09185622
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.08143014
92CTCF_27219007_Chip-Seq_Bcells_Human1.06438609
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06149998
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06004768
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04527130
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04092562
97JUN_21703547_ChIP-Seq_K562_Human1.03999128
98MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03329513
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02557877
100TP53_18474530_ChIP-ChIP_U2OS_Human1.02243546
101AR_19668381_ChIP-Seq_PC3_Human1.01161431
102ER_23166858_ChIP-Seq_MCF-7_Human1.01057496
103BCAT_22108803_ChIP-Seq_LS180_Human0.99922034
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99896207
105IRF1_19129219_ChIP-ChIP_H3396_Human0.99223808
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98423193
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98389305
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96965709
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96514936
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95788513
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95434950
112CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95410339
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.95376763
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.95376763
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.95179884
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94888855
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93813005
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93234953
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92787114
120DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92587152
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92486948
122FLI1_21867929_ChIP-Seq_TH2_Mouse0.92127769
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92038863
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91902169
125RING1B_27294783_Chip-Seq_ESCs_Mouse0.91503660
126RNF2_27304074_Chip-Seq_NSC_Mouse0.90936779
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89104725
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88448689
129FLI1_27457419_Chip-Seq_LIVER_Mouse0.86021342
130TCF4_23295773_ChIP-Seq_U87_Human0.85344690
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84310923
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83984427
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.83278580
134KDM2B_26808549_Chip-Seq_REH_Human0.81097648
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78679119
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78679119

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.49536803
2MP0000749_muscle_degeneration5.85963485
3MP0000751_myopathy5.68143416
4MP0002837_dystrophic_cardiac_calcinosis4.42437940
5MP0000747_muscle_weakness4.07229083
6MP0003646_muscle_fatigue3.71196289
7MP0002106_abnormal_muscle_physiology3.62991758
8MP0004036_abnormal_muscle_relaxation3.27515447
9MP0000759_abnormal_skeletal_muscle3.23787591
10MP0002102_abnormal_ear_morphology3.07599066
11MP0005369_muscle_phenotype3.07231709
12MP0002269_muscular_atrophy3.04728555
13MP0004087_abnormal_muscle_fiber3.03441011
14MP0000750_abnormal_muscle_regeneration2.96523091
15MP0004270_analgesia2.85584227
16MP0005620_abnormal_muscle_contractility2.81623952
17MP0000778_abnormal_nervous_system2.57896019
18MP0004233_abnormal_muscle_weight2.24415748
19MP0000733_abnormal_muscle_development2.23395696
20MP0003950_abnormal_plasma_membrane2.13095927
21MP0004084_abnormal_cardiac_muscle2.11431152
22MP0001984_abnormal_olfaction2.09006441
23MP0002108_abnormal_muscle_morphology2.05210679
24MP0004859_abnormal_synaptic_plasticity2.03300764
25MP0005330_cardiomyopathy2.03122308
26MP0004484_altered_response_of2.00788413
27MP0004215_abnormal_myocardial_fiber1.99042574
28MP0004130_abnormal_muscle_cell1.98151376
29MP0003122_maternal_imprinting1.95583005
30MP0003880_abnormal_central_pattern1.91585759
31MP0003787_abnormal_imprinting1.90865665
32MP0005394_taste/olfaction_phenotype1.88392639
33MP0005499_abnormal_olfactory_system1.88392639
34MP0002332_abnormal_exercise_endurance1.87598063
35MP0004885_abnormal_endolymph1.79511388
36MP0008789_abnormal_olfactory_epithelium1.74923782
37MP0004133_heterotaxia1.68415816
38MP0001485_abnormal_pinna_reflex1.62590107
39MP0002653_abnormal_ependyma_morphology1.60370270
40MP0002972_abnormal_cardiac_muscle1.57085872
41MP0001188_hyperpigmentation1.55071239
42MP0006292_abnormal_olfactory_placode1.45782568
43MP0004272_abnormal_basement_membrane1.44295380
44MP0002882_abnormal_neuron_morphology1.43380411
45MP0000049_abnormal_middle_ear1.42572889
46MP0002751_abnormal_autonomic_nervous1.41671117
47MP0002638_abnormal_pupillary_reflex1.41567092
48MP0003635_abnormal_synaptic_transmissio1.38747788
49MP0004742_abnormal_vestibular_system1.32118593
50MP0000013_abnormal_adipose_tissue1.30385038
51MP0005503_abnormal_tendon_morphology1.30334683
52MP0000566_synostosis1.29604868
53MP0002752_abnormal_somatic_nervous1.26818721
54MP0003123_paternal_imprinting1.24582169
55MP0006036_abnormal_mitochondrial_physio1.24451104
56MP0005551_abnormal_eye_electrophysiolog1.24381974
57MP0006276_abnormal_autonomic_nervous1.22594501
58MP0004510_myositis1.21650222
59MP0003283_abnormal_digestive_organ1.21163080
60MP0000631_abnormal_neuroendocrine_gland1.21026257
61MP0000026_abnormal_inner_ear1.20863028
62MP0005187_abnormal_penis_morphology1.19552047
63MP0002734_abnormal_mechanical_nocicepti1.18893198
64MP0009745_abnormal_behavioral_response1.18814003
65MP0003137_abnormal_impulse_conducting1.16058266
66MP0002152_abnormal_brain_morphology1.15987661
67MP0003938_abnormal_ear_development1.15220572
68MP0003890_abnormal_embryonic-extraembry1.13900050
69MP0009780_abnormal_chondrocyte_physiolo1.12193571
70MP0008438_abnormal_cutaneous_collagen1.11835176
71MP0005275_abnormal_skin_tensile1.11432870
72MP0008877_abnormal_DNA_methylation1.08360690
73MP0005645_abnormal_hypothalamus_physiol1.08356276
74MP0003136_yellow_coat_color1.07887840
75MP0008995_early_reproductive_senescence1.07366331
76MP0001440_abnormal_grooming_behavior1.03100553
77MP0003119_abnormal_digestive_system1.02752027
78MP0003861_abnormal_nervous_system1.02321532
79MP0002233_abnormal_nose_morphology1.02300200
80MP0002928_abnormal_bile_duct1.01987635
81MP0002063_abnormal_learning/memory/cond0.99942247
82MP0001529_abnormal_vocalization0.99695559
83MP0006072_abnormal_retinal_apoptosis0.99472182
84MP0001986_abnormal_taste_sensitivity0.97773159
85MP0010630_abnormal_cardiac_muscle0.96638545
86MP0005646_abnormal_pituitary_gland0.95471490
87MP0000569_abnormal_digit_pigmentation0.94592073
88MP0009046_muscle_twitch0.94073896
89MP0005084_abnormal_gallbladder_morpholo0.93195689
90MP0005623_abnormal_meninges_morphology0.93029531
91MP0001963_abnormal_hearing_physiology0.92511253
92MP0002064_seizures0.91824430
93MP0001502_abnormal_circadian_rhythm0.90687358
94MP0005253_abnormal_eye_physiology0.90454809
95MP0002736_abnormal_nociception_after0.89936217
96MP0001968_abnormal_touch/_nociception0.89919218
97MP0002971_abnormal_brown_adipose0.89313613
98MP0002184_abnormal_innervation0.88979253
99MP0001293_anophthalmia0.87533620
100MP0004134_abnormal_chest_morphology0.87040109
101MP0004085_abnormal_heartbeat0.85870007
102MP0003937_abnormal_limbs/digits/tail_de0.85420761
103MP0005195_abnormal_posterior_eye0.85352661
104MP0001177_atelectasis0.82439682
105MP0002069_abnormal_eating/drinking_beha0.81954101
106MP0002127_abnormal_cardiovascular_syste0.80119991
107MP0005266_abnormal_metabolism0.80096291
108MP0010386_abnormal_urinary_bladder0.79731858
109MP0002938_white_spotting0.79219653
110MP0002572_abnormal_emotion/affect_behav0.79096570
111MP0002067_abnormal_sensory_capabilities0.78400753
112MP0003121_genomic_imprinting0.77281242
113MP0009250_abnormal_appendicular_skeleto0.77182971
114MP0002272_abnormal_nervous_system0.77054457
115MP0002229_neurodegeneration0.76719172
116MP0003755_abnormal_palate_morphology0.75368427
117MP0003633_abnormal_nervous_system0.75270951
118MP0001299_abnormal_eye_distance/0.75078440
119MP0001286_abnormal_eye_development0.73974246
120MP0002282_abnormal_trachea_morphology0.73895352
121MP0001501_abnormal_sleep_pattern0.73791698
122MP0008569_lethality_at_weaning0.73742017
123MP0005385_cardiovascular_system_phenoty0.72837834
124MP0001544_abnormal_cardiovascular_syste0.72837834
125MP0000534_abnormal_ureter_morphology0.72565831
126MP0004142_abnormal_muscle_tone0.72180375
127MP0003011_delayed_dark_adaptation0.69895035
128MP0000647_abnormal_sebaceous_gland0.68476361
129MP0006035_abnormal_mitochondrial_morpho0.68109218
130MP0008775_abnormal_heart_ventricle0.67937405
131MP0002066_abnormal_motor_capabilities/c0.66233389
132MP0002089_abnormal_postnatal_growth/wei0.66172905
133MP0002234_abnormal_pharynx_morphology0.63112061
134MP0001486_abnormal_startle_reflex0.61742501
135MP0002735_abnormal_chemical_nociception0.59931939
136MP0003385_abnormal_body_wall0.57187305
137MP0002114_abnormal_axial_skeleton0.55896188
138MP0004924_abnormal_behavior0.55781465
139MP0005386_behavior/neurological_phenoty0.55781465
140MP0002822_catalepsy0.53558609
141MP0000955_abnormal_spinal_cord0.52721974
142MP0001943_abnormal_respiration0.52586448
143MP0003879_abnormal_hair_cell0.50981897
144MP0003329_amyloid_beta_deposits0.49254098
145MP0001970_abnormal_pain_threshold0.48672618
146MP0006138_congestive_heart_failure0.47938127
147MP0001905_abnormal_dopamine_level0.47138684
148MP0003941_abnormal_skin_development0.47105207
149MP0004811_abnormal_neuron_physiology0.44361202
150MP0005452_abnormal_adipose_tissue0.43848987
151MP0000003_abnormal_adipose_tissue0.43659869
152MP0002909_abnormal_adrenal_gland0.43330360
153MP0002733_abnormal_thermal_nociception0.43313516
154MP0000762_abnormal_tongue_morphology0.42954129
155MP0005535_abnormal_body_temperature0.41859751
156MP0005423_abnormal_somatic_nervous0.40922312
157MP0000266_abnormal_heart_morphology0.40651267
158MP0003948_abnormal_gas_homeostasis0.40177224
159MP0002557_abnormal_social/conspecific_i0.38973957

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.21777687
2Nemaline bodies (HP:0003798)9.17530040
3Muscle fiber inclusion bodies (HP:0100299)9.12808881
4Type 1 muscle fiber predominance (HP:0003803)8.22432742
5Round ear (HP:0100830)6.59051227
6Exercise-induced myalgia (HP:0003738)6.40202397
7Muscle hypertrophy of the lower extremities (HP:0008968)6.08850363
8Myopathic facies (HP:0002058)6.08057006
9Calf muscle hypertrophy (HP:0008981)6.05228275
10Ulnar deviation of the wrist (HP:0003049)5.92997489
11Exercise-induced muscle cramps (HP:0003710)5.60335484
12Calcaneovalgus deformity (HP:0001848)5.31283848
13Deformed tarsal bones (HP:0008119)4.75021824
14Absent phalangeal crease (HP:0006109)4.61291988
15Muscle fiber splitting (HP:0003555)4.58400488
16EMG: myopathic abnormalities (HP:0003458)4.56781704
17Abnormality of the calf musculature (HP:0001430)4.55985006
18Fetal akinesia sequence (HP:0001989)4.36329940
19Myokymia (HP:0002411)4.07471044
20Slender build (HP:0001533)3.94052306
21Difficulty running (HP:0009046)3.90306893
22Abnormal finger flexion creases (HP:0006143)3.90059302
23Neck muscle weakness (HP:0000467)3.87242018
24Hyporeflexia of lower limbs (HP:0002600)3.82657734
25Abnormality of skeletal muscle fiber size (HP:0012084)3.66920615
26Limb dystonia (HP:0002451)3.57502235
27Malignant hyperthermia (HP:0002047)3.55610731
28Polyphagia (HP:0002591)3.46538089
29Trismus (HP:0000211)3.46005311
30Frequent falls (HP:0002359)3.42382767
31Gait imbalance (HP:0002141)3.38908211
32Rimmed vacuoles (HP:0003805)3.35823266
33Neoplasm of the heart (HP:0100544)3.29904658
34Increased connective tissue (HP:0009025)3.28494822
35Mildly elevated creatine phosphokinase (HP:0008180)3.26095818
36Myotonia (HP:0002486)3.25947858
37True hermaphroditism (HP:0010459)3.25019369
38Febrile seizures (HP:0002373)3.24530667
39Metatarsus adductus (HP:0001840)3.22183176
40Focal seizures (HP:0007359)3.21674646
41Drooling (HP:0002307)3.21221282
42Increased variability in muscle fiber diameter (HP:0003557)3.20480388
43Sudden death (HP:0001699)3.13401336
44Cortical dysplasia (HP:0002539)3.13202070
45Abnormality of the calcaneus (HP:0008364)3.11265578
46Medial flaring of the eyebrow (HP:0010747)3.07658440
47Bulbar palsy (HP:0001283)3.06701627
48Congenital primary aphakia (HP:0007707)2.99785105
49Pancreatic fibrosis (HP:0100732)2.96873899
50Abnormality of the corticospinal tract (HP:0002492)2.96712702
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.95206050
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.95206050
53Muscle stiffness (HP:0003552)2.94002905
54Excessive salivation (HP:0003781)2.92021608
55Progressive cerebellar ataxia (HP:0002073)2.88533384
56Shoulder girdle muscle weakness (HP:0003547)2.86768166
57Nephrogenic diabetes insipidus (HP:0009806)2.86309234
58Nephronophthisis (HP:0000090)2.85885629
59Myoglobinuria (HP:0002913)2.85811170
60Molar tooth sign on MRI (HP:0002419)2.79580116
61Abnormality of midbrain morphology (HP:0002418)2.79580116
62Gowers sign (HP:0003391)2.77220811
63Difficulty climbing stairs (HP:0003551)2.76425523
64Spinal rigidity (HP:0003306)2.74165434
65Genital tract atresia (HP:0001827)2.72905355
66Centrally nucleated skeletal muscle fibers (HP:0003687)2.71140217
67Vaginal atresia (HP:0000148)2.69743719
68EMG: neuropathic changes (HP:0003445)2.69674762
69Failure to thrive in infancy (HP:0001531)2.68012678
70Symphalangism affecting the phalanges of the hand (HP:0009773)2.66719051
71Subaortic stenosis (HP:0001682)2.65414525
72Abnormality of the left ventricular outflow tract (HP:0011103)2.65414525
73Pancreatic cysts (HP:0001737)2.65268997
74Impaired vibration sensation in the lower limbs (HP:0002166)2.64598543
75Generalized muscle weakness (HP:0003324)2.63881637
76Abnormality of the neuromuscular junction (HP:0003398)2.62691885
77Fatigable weakness (HP:0003473)2.62691885
78Pelvic girdle muscle weakness (HP:0003749)2.60305273
79Abnormality of the hip-girdle musculature (HP:0001445)2.57370879
80Abnormality of the musculature of the pelvis (HP:0001469)2.57370879
81Amblyopia (HP:0000646)2.55975282
82Weak cry (HP:0001612)2.55190552
83Intestinal atresia (HP:0011100)2.53739359
84Abnormality of the labia minora (HP:0012880)2.51502497
85Sleep apnea (HP:0010535)2.49282104
86Urinary urgency (HP:0000012)2.48713503
87Lissencephaly (HP:0001339)2.46421214
88Hip contracture (HP:0003273)2.45918191
89Poor suck (HP:0002033)2.45326339
90Specific learning disability (HP:0001328)2.45135808
91Dialeptic seizures (HP:0011146)2.44492114
92Popliteal pterygium (HP:0009756)2.42532002
93Amniotic constriction ring (HP:0009775)2.41754091
94Abnormality of placental membranes (HP:0011409)2.41754091
95Type 2 muscle fiber atrophy (HP:0003554)2.38639419
96Generalized tonic-clonic seizures (HP:0002069)2.38294595
97Rhabdomyolysis (HP:0003201)2.35278053
98Abnormal eating behavior (HP:0100738)2.34184524
99Epileptic encephalopathy (HP:0200134)2.34140603
100Retinal dysplasia (HP:0007973)2.33815672
101Amyotrophic lateral sclerosis (HP:0007354)2.32995341
102Respiratory insufficiency due to muscle weakness (HP:0002747)2.32605337
103Ulnar deviation of finger (HP:0009465)2.29945263
104Hypoplasia of the brainstem (HP:0002365)2.28712967
105Aplasia/Hypoplasia of the brainstem (HP:0007362)2.28712967
106Abnormality of the renal medulla (HP:0100957)2.27048896
107Agitation (HP:0000713)2.24348147
108Hyperventilation (HP:0002883)2.23760774
109Ulnar claw (HP:0001178)2.22819263
110Muscle fiber atrophy (HP:0100295)2.21151279
111Pachygyria (HP:0001302)2.19763647
112Broad-based gait (HP:0002136)2.18064996
113Absence seizures (HP:0002121)2.14618070
114Poor coordination (HP:0002370)2.12644025
115Morphological abnormality of the pyramidal tract (HP:0002062)2.11263308
116Asymmetric septal hypertrophy (HP:0001670)2.08593133
117Rib fusion (HP:0000902)2.08194348
118Sclerocornea (HP:0000647)2.07548762
119Spastic tetraplegia (HP:0002510)2.06379173
120Abnormality of the lower motor neuron (HP:0002366)2.05823721
121Hemiparesis (HP:0001269)2.05190472
122Anencephaly (HP:0002323)2.04603451
123Scapular winging (HP:0003691)2.03841418
124Spastic gait (HP:0002064)2.03696381
125Areflexia of lower limbs (HP:0002522)2.03058121
126Gastrointestinal atresia (HP:0002589)2.02422235
127Proximal amyotrophy (HP:0007126)2.02145175
128Genetic anticipation (HP:0003743)2.00676481
129Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00669528
130Epileptiform EEG discharges (HP:0011182)2.00076387
131Distal arthrogryposis (HP:0005684)10.7274111
132Optic nerve hypoplasia (HP:0000609)1.99846544
133Waddling gait (HP:0002515)1.98941761
134Abnormality of the shoulder girdle musculature (HP:0001435)1.98628017
135Chronic hepatic failure (HP:0100626)1.97845946
136Inability to walk (HP:0002540)1.97527875
137Postaxial hand polydactyly (HP:0001162)1.97206360
138Septo-optic dysplasia (HP:0100842)1.96969443
139Hypsarrhythmia (HP:0002521)1.96923036
140Anophthalmia (HP:0000528)1.96693593
141Aplasia of the musculature (HP:0100854)1.96214004
142Limb-girdle muscle weakness (HP:0003325)1.96195939
143Muscular dystrophy (HP:0003560)1.93306996
144Progressive inability to walk (HP:0002505)1.92876194
145Urinary bladder sphincter dysfunction (HP:0002839)1.91381693
146EEG with generalized epileptiform discharges (HP:0011198)1.91359087
147Narrow forehead (HP:0000341)1.91162846
148Hypoplastic ischia (HP:0003175)1.89820754
149Abnormal respiratory epithelium morphology (HP:0012253)1.88878701
150Abnormal respiratory motile cilium morphology (HP:0005938)1.88878701
151Cystic liver disease (HP:0006706)1.88397335
152Type II lissencephaly (HP:0007260)1.88220892
153Breech presentation (HP:0001623)1.85055924
154Exotropia (HP:0000577)1.84267608
155Nonprogressive disorder (HP:0003680)1.84022689
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.83807016
157Occipital encephalocele (HP:0002085)1.81487837
158Esotropia (HP:0000565)1.80523746
159Distal lower limb amyotrophy (HP:0008944)1.80231942
160Broad foot (HP:0001769)1.80009548
161Akinesia (HP:0002304)1.78337733
162Split foot (HP:0001839)1.78287920
163Limb-girdle muscle atrophy (HP:0003797)1.77417050
164Facial diplegia (HP:0001349)1.76910593
165Focal motor seizures (HP:0011153)1.76445385
166Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76240929
167Abnormal respiratory motile cilium physiology (HP:0012261)1.75964898
168Adducted thumb (HP:0001181)1.75309179
169Abnormal ciliary motility (HP:0012262)1.75089854
170Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.74763049
171Hepatoblastoma (HP:0002884)1.74058964
172Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73244033
173Action tremor (HP:0002345)1.71533281
174Acute necrotizing encephalopathy (HP:0006965)1.68922924
175Aplasia/Hypoplasia of the lens (HP:0008063)1.68767436
176Hypothermia (HP:0002045)1.68011984
177Status epilepticus (HP:0002133)1.67399766
178Growth hormone deficiency (HP:0000824)1.66650026
179Abnormality of salivation (HP:0100755)1.66392974
180Distal lower limb muscle weakness (HP:0009053)1.66373567
181Limited hip movement (HP:0008800)1.64842800
182Abnormality of the ischium (HP:0003174)1.63105588
183Webbed neck (HP:0000465)1.59106439
184Progressive muscle weakness (HP:0003323)1.58218999
185Long clavicles (HP:0000890)1.52233859
186Tarsal synostosis (HP:0008368)1.50495359
187Hyperkalemia (HP:0002153)1.49950475
188Rocker bottom foot (HP:0001838)1.48226207
189Atonic seizures (HP:0010819)1.47022302
190Lower limb amyotrophy (HP:0007210)1.46966639
191Achilles tendon contracture (HP:0001771)1.44894116
192Easy fatigability (HP:0003388)1.44678956
193Congenital hip dislocation (HP:0001374)1.40653758
194Synostosis involving bones of the lower limbs (HP:0009138)1.38777766

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN9.44991445
2PIK3CG4.79234996
3TTN3.89476114
4PHKG23.68136234
5PHKG13.68136234
6BCR3.39762590
7NME13.37980578
8MUSK2.91062047
9WNK32.55465372
10TRIM282.39988755
11DYRK22.20573529
12MAP4K22.04832319
13UHMK12.03648220
14DYRK31.94023133
15MAP2K41.92840408
16ERBB31.82472573
17MAPK151.72748807
18MAP3K121.72189927
19NTRK31.67794503
20PDK31.65683240
21PDK41.65683240
22CASK1.63880126
23EPHA31.59029332
24NEK11.56649368
25TNIK1.55702010
26MAPK121.53331895
27EPHA41.42654343
28MAP3K41.39638701
29DYRK1B1.35854526
30PNCK1.34627241
31CSNK1G31.27218124
32MOS1.25974475
33DMPK1.23977512
34PINK11.23292371
35PIK3CA1.21539251
36MAP3K91.19496933
37DYRK1A1.18354477
38SIK31.17809054
39CSNK1A1L1.16612102
40TRIB31.13367212
41SIK11.12152791
42MAP3K71.11793528
43ADRBK21.10070744
44MARK11.07970616
45GRK71.06403384
46PLK21.06170338
47MAP2K30.99310208
48CSNK1G10.97622827
49PTK2B0.96347881
50EPHB20.96307791
51PDK20.93183392
52GRK50.92870220
53SGK2230.92118807
54SGK4940.92118807
55CCNB10.87162660
56INSRR0.84431516
57CAMK2A0.84387288
58RPS6KA40.84313347
59CAMK2G0.83229635
60VRK10.82561713
61BCKDK0.81880720
62WEE10.81836434
63MAP3K60.80488092
64MAP2K60.79598303
65PRKCE0.79444312
66MAP2K70.78850682
67ROCK20.74544880
68DAPK20.72679516
69SRPK10.71431239
70CAMKK20.69170752
71BMPR1B0.68738645
72PAK60.66168429
73MINK10.66126653
74MAPKAPK30.65587957
75WNK40.64746758
76TSSK60.64184915
77FRK0.64159098
78ILK0.64025145
79KSR10.63938733
80TYRO30.61791566
81STK390.60425189
82KSR20.60178225
83AKT20.60054971
84MAP2K10.59352112
85SGK20.58741467
86ADRBK10.58035882
87CAMK40.57119320
88PKN20.56427091
89MKNK20.56096206
90LATS20.55907427
91GRK10.55492254
92ROCK10.55179097
93FGR0.52871939
94CDK190.52731623
95PLK30.52596654
96FGFR20.52433847
97CAMKK10.51857326
98MAPKAPK50.51655425
99MAPK130.50825926
100MKNK10.50592376
101CDK50.49774452
102PRKCZ0.48989440
103PRKG10.48945494
104TLK10.47429548
105MYLK0.47016569
106DAPK10.46489471
107CDK30.46298032
108CAMK2D0.45746869
109CDK140.44374112
110CAMK2B0.43513914
111FER0.42872068
112PRKCG0.42322181
113MAPK70.42008229
114SGK10.41934057
115CAMK10.41149030
116ARAF0.39346840
117DAPK30.39184494
118PRKACA0.38701426
119PRKACB0.38218363
120RPS6KA30.36886257
121NTRK20.36597110
122CSNK1A10.36264497
123TAOK20.36248520
124STK110.35559347
125MAP3K50.34433105
126CDK180.33949508
127STK240.33543830
128PRKAA10.33144383
129RIPK40.33088451
130PDPK10.33040260
131CDK150.32976201
132PKN10.32769795
133LIMK10.30025221
134PAK30.29012021
135CSNK1D0.28279483
136PRKD30.27173813
137MAPK40.26986642
138GRK60.26850994
139CDK11A0.26195505
140TIE10.25717240
141ERBB20.25199407
142MAP3K100.24680240
143PDK10.23901766
144MAPK100.23089651
145PRKAA20.19662312
146PDGFRA0.19029010
147CSNK1E0.18824066
148OXSR10.18249383
149ERBB40.17432208
150CSNK1G20.16521492
151MAPK110.15841159
152NTRK10.15498552
153SIK20.15099814

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042604.10854912
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.21022394
3Dilated cardiomyopathy_Homo sapiens_hsa054143.14410478
4Oxidative phosphorylation_Homo sapiens_hsa001903.00549021
5Parkinsons disease_Homo sapiens_hsa050122.76550977
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.72802475
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.66443123
8Phototransduction_Homo sapiens_hsa047442.41672998
9Alzheimers disease_Homo sapiens_hsa050102.37221649
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.31517140
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.25839134
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.22225255
13Oxytocin signaling pathway_Homo sapiens_hsa049212.18791439
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13766850
15Protein export_Homo sapiens_hsa030602.04701537
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00222451
17Nicotine addiction_Homo sapiens_hsa050331.93134232
18Gastric acid secretion_Homo sapiens_hsa049711.87499451
19Salivary secretion_Homo sapiens_hsa049701.83710749
20Calcium signaling pathway_Homo sapiens_hsa040201.76681025
21Renin secretion_Homo sapiens_hsa049241.66480693
22Huntingtons disease_Homo sapiens_hsa050161.66085659
23Insulin secretion_Homo sapiens_hsa049111.65132896
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.60632119
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59326655
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55154314
27Glucagon signaling pathway_Homo sapiens_hsa049221.54921074
28Long-term depression_Homo sapiens_hsa047301.53156196
29Long-term potentiation_Homo sapiens_hsa047201.51334817
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49149044
31Circadian entrainment_Homo sapiens_hsa047131.46477983
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.45031298
33Collecting duct acid secretion_Homo sapiens_hsa049661.44812726
34Synaptic vesicle cycle_Homo sapiens_hsa047211.43736982
35Tight junction_Homo sapiens_hsa045301.39463262
36GABAergic synapse_Homo sapiens_hsa047271.36868030
37Butanoate metabolism_Homo sapiens_hsa006501.31745715
38Amphetamine addiction_Homo sapiens_hsa050311.28572847
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26498590
40Steroid biosynthesis_Homo sapiens_hsa001001.26175212
41Olfactory transduction_Homo sapiens_hsa047401.22205910
42Insulin signaling pathway_Homo sapiens_hsa049101.19955141
43Morphine addiction_Homo sapiens_hsa050321.16392575
44Dopaminergic synapse_Homo sapiens_hsa047281.14861903
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.14242711
46GnRH signaling pathway_Homo sapiens_hsa049121.13952873
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12863707
48Hedgehog signaling pathway_Homo sapiens_hsa043401.11887118
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11087403
50Taste transduction_Homo sapiens_hsa047421.06885069
51Starch and sucrose metabolism_Homo sapiens_hsa005001.06191936
52Serotonergic synapse_Homo sapiens_hsa047261.05190267
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02882414
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99773787
55Gap junction_Homo sapiens_hsa045400.95176084
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94840935
57Cholinergic synapse_Homo sapiens_hsa047250.94642220
58Focal adhesion_Homo sapiens_hsa045100.93506542
59Glutamatergic synapse_Homo sapiens_hsa047240.91537769
60Alcoholism_Homo sapiens_hsa050340.90698746
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89243714
62Vibrio cholerae infection_Homo sapiens_hsa051100.89213815
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87291755
64Basal cell carcinoma_Homo sapiens_hsa052170.87264288
65Carbon metabolism_Homo sapiens_hsa012000.86681594
66Basal transcription factors_Homo sapiens_hsa030220.86187895
67Pyruvate metabolism_Homo sapiens_hsa006200.85981771
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.85081992
69Circadian rhythm_Homo sapiens_hsa047100.84351332
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83911488
71Protein digestion and absorption_Homo sapiens_hsa049740.81399418
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81242952
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79085800
74AMPK signaling pathway_Homo sapiens_hsa041520.79007539
75Cocaine addiction_Homo sapiens_hsa050300.78816893
76Insulin resistance_Homo sapiens_hsa049310.77818481
77cAMP signaling pathway_Homo sapiens_hsa040240.77545621
78Thyroid hormone synthesis_Homo sapiens_hsa049180.76804390
79Fanconi anemia pathway_Homo sapiens_hsa034600.76479320
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75873609
81Melanogenesis_Homo sapiens_hsa049160.74223337
82Linoleic acid metabolism_Homo sapiens_hsa005910.73373389
83Hippo signaling pathway_Homo sapiens_hsa043900.71649079
84MAPK signaling pathway_Homo sapiens_hsa040100.70258402
85ECM-receptor interaction_Homo sapiens_hsa045120.68651370
86Viral myocarditis_Homo sapiens_hsa054160.65107083
87Wnt signaling pathway_Homo sapiens_hsa043100.64062233
88Estrogen signaling pathway_Homo sapiens_hsa049150.63427118
89Propanoate metabolism_Homo sapiens_hsa006400.61619134
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61188291
91Amoebiasis_Homo sapiens_hsa051460.61139219
92Ether lipid metabolism_Homo sapiens_hsa005650.60834870
93Bile secretion_Homo sapiens_hsa049760.59858615
94mTOR signaling pathway_Homo sapiens_hsa041500.59234342
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.59226091
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58139190
97Pancreatic secretion_Homo sapiens_hsa049720.57608864
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56744191
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55598197
100Oocyte meiosis_Homo sapiens_hsa041140.55003320
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54981102
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53592416
103Ras signaling pathway_Homo sapiens_hsa040140.53325443
104Biosynthesis of amino acids_Homo sapiens_hsa012300.53289430
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53219993
106Regulation of autophagy_Homo sapiens_hsa041400.52428991
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.50464729
108Type II diabetes mellitus_Homo sapiens_hsa049300.50175734
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49894129
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49790150
111Fructose and mannose metabolism_Homo sapiens_hsa000510.49528113
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49014987
113Galactose metabolism_Homo sapiens_hsa000520.47901248
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.47424095
115RNA degradation_Homo sapiens_hsa030180.46774268
116Mineral absorption_Homo sapiens_hsa049780.46402915
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45536533
118Axon guidance_Homo sapiens_hsa043600.45494885
119Glioma_Homo sapiens_hsa052140.44426603
120Nitrogen metabolism_Homo sapiens_hsa009100.44087789
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43269683
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40667026
123HIF-1 signaling pathway_Homo sapiens_hsa040660.40463324
124VEGF signaling pathway_Homo sapiens_hsa043700.38305557
125Rap1 signaling pathway_Homo sapiens_hsa040150.37749606
126Peroxisome_Homo sapiens_hsa041460.37090166
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36839575
128ErbB signaling pathway_Homo sapiens_hsa040120.36004172
129Ribosome_Homo sapiens_hsa030100.34888375
130Proteoglycans in cancer_Homo sapiens_hsa052050.34483731
131Prion diseases_Homo sapiens_hsa050200.34472395
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31836521
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31572442
134Folate biosynthesis_Homo sapiens_hsa007900.31511430
135FoxO signaling pathway_Homo sapiens_hsa040680.31026231
136Tryptophan metabolism_Homo sapiens_hsa003800.30524187
137Ovarian steroidogenesis_Homo sapiens_hsa049130.30262105
138RNA polymerase_Homo sapiens_hsa030200.29913474
139Renal cell carcinoma_Homo sapiens_hsa052110.29612929
140Platelet activation_Homo sapiens_hsa046110.29290189
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29277154
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27699394
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27569680

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