TCEAL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)4.68878920
2bone trabecula formation (GO:0060346)4.64618370
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.58309983
4chromatin remodeling at centromere (GO:0031055)4.41748679
5ATP synthesis coupled proton transport (GO:0015986)4.27632329
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.27632329
7positive regulation of oligodendrocyte differentiation (GO:0048714)4.18340731
8cullin deneddylation (GO:0010388)4.11388078
9chaperone-mediated protein transport (GO:0072321)4.10214189
10histone exchange (GO:0043486)3.76976459
11DNA double-strand break processing (GO:0000729)3.64962671
12respiratory chain complex IV assembly (GO:0008535)3.62734906
13DNA damage response, detection of DNA damage (GO:0042769)3.61650889
14protein deneddylation (GO:0000338)3.61545456
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57187278
16exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51613176
17nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50711926
18establishment of integrated proviral latency (GO:0075713)3.46907149
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.44236398
20NADH dehydrogenase complex assembly (GO:0010257)3.44236398
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44236398
22paraxial mesoderm development (GO:0048339)3.40199904
23ribosomal small subunit biogenesis (GO:0042274)3.39832381
24DNA replication-independent nucleosome organization (GO:0034724)3.34071954
25DNA replication-independent nucleosome assembly (GO:0006336)3.34071954
26purine nucleobase biosynthetic process (GO:0009113)3.32624381
27regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.31649026
28peptidyl-histidine modification (GO:0018202)3.23321846
29regulation of mitochondrial translation (GO:0070129)3.19182020
30cotranslational protein targeting to membrane (GO:0006613)3.18757033
31cytochrome complex assembly (GO:0017004)3.17420130
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14848840
33spinal cord association neuron differentiation (GO:0021527)3.13304398
34forebrain neuron differentiation (GO:0021879)3.13157414
35protein targeting to ER (GO:0045047)3.12935619
36regulation of mitotic spindle checkpoint (GO:1903504)3.12827196
37regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12827196
38protein K11-linked ubiquitination (GO:0070979)3.11567168
39regulation of helicase activity (GO:0051095)3.00924448
40respiratory electron transport chain (GO:0022904)2.97976750
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97433648
42short-term memory (GO:0007614)2.97303680
43chondrocyte proliferation (GO:0035988)2.97191514
44establishment of protein localization to endoplasmic reticulum (GO:0072599)2.95146815
45establishment of viral latency (GO:0019043)2.94102962
46negative regulation of DNA-dependent DNA replication (GO:2000104)2.93490517
47protein complex biogenesis (GO:0070271)2.92736058
48protein localization to endoplasmic reticulum (GO:0070972)2.92087085
49lateral sprouting from an epithelium (GO:0060601)2.90201420
50electron transport chain (GO:0022900)2.90058616
51mitotic G2 DNA damage checkpoint (GO:0007095)2.88903815
52ribosome assembly (GO:0042255)2.86886361
53histone mRNA metabolic process (GO:0008334)2.86853226
54forebrain morphogenesis (GO:0048853)2.86034796
55translational termination (GO:0006415)2.85814186
567-methylguanosine mRNA capping (GO:0006370)2.85610931
57RNA capping (GO:0036260)2.82766388
587-methylguanosine RNA capping (GO:0009452)2.82766388
59inner mitochondrial membrane organization (GO:0007007)2.82356206
60oxidative phosphorylation (GO:0006119)2.81940778
61water-soluble vitamin biosynthetic process (GO:0042364)2.81672074
62proteasome assembly (GO:0043248)2.81640122
63viral transcription (GO:0019083)2.81075823
64rRNA modification (GO:0000154)2.80727824
65sequestering of actin monomers (GO:0042989)2.78359823
66DNA ligation (GO:0006266)2.78254272
67limb bud formation (GO:0060174)2.77983852
68DNA replication checkpoint (GO:0000076)2.76193319
69regulation of respiratory system process (GO:0044065)2.75764902
70nucleobase biosynthetic process (GO:0046112)2.75669990
71establishment of protein localization to mitochondrial membrane (GO:0090151)2.73377751
72negative regulation of ligase activity (GO:0051352)2.73190014
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73190014
74positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71624950
75resolution of meiotic recombination intermediates (GO:0000712)2.71384080
76protein targeting to mitochondrion (GO:0006626)2.69365659
77kinetochore assembly (GO:0051382)2.69065486
78RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68039670
79tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68039670
80regulation of cellular amino acid metabolic process (GO:0006521)2.67905003
81DNA catabolic process, exonucleolytic (GO:0000738)2.67808466
82protein maturation by protein folding (GO:0022417)2.67798316
83IMP biosynthetic process (GO:0006188)2.67053669
84platelet dense granule organization (GO:0060155)2.66903068
85protein peptidyl-prolyl isomerization (GO:0000413)2.66749706
86GTP biosynthetic process (GO:0006183)2.64615756
87mitochondrial respiratory chain complex assembly (GO:0033108)2.64404310
88protein localization to mitochondrion (GO:0070585)2.62702729
89establishment of protein localization to mitochondrion (GO:0072655)2.59382492
90sequestering of extracellular ligand from receptor (GO:0035581)2.59351257
91positive regulation of ligase activity (GO:0051351)2.58610252
92kinetochore organization (GO:0051383)2.58102038
93cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.57951616
94ATP biosynthetic process (GO:0006754)2.57612508
95regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.56030722
96mitotic G2/M transition checkpoint (GO:0044818)2.55284369
97organelle disassembly (GO:1903008)2.55178611
98somite rostral/caudal axis specification (GO:0032525)2.54849651
99spliceosomal complex assembly (GO:0000245)2.54197030
100DNA replication-dependent nucleosome organization (GO:0034723)2.53033142
101DNA replication-dependent nucleosome assembly (GO:0006335)2.53033142
102female gonad development (GO:0008585)2.52606516
103regulation of mesoderm development (GO:2000380)2.51385072
104regulation of ubiquitin-protein transferase activity (GO:0051438)2.51247295
105protein-cofactor linkage (GO:0018065)2.51149809
106neuron fate specification (GO:0048665)2.50519170
107DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.49536842
108intracellular protein transmembrane import (GO:0044743)2.49355930
109positive regulation of Notch signaling pathway (GO:0045747)2.49336825
110anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.49166722
111translation (GO:0006412)2.48327198
112rRNA methylation (GO:0031167)2.47729382
113purine nucleoside triphosphate biosynthetic process (GO:0009145)2.47396118
114negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.47314495
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.47314495
116negative regulation of mitotic sister chromatid segregation (GO:0033048)2.47314495
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.47314495
118negative regulation of sister chromatid segregation (GO:0033046)2.47314495
119signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.47251118
120signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.47251118
121signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.47251118
122spliceosomal snRNP assembly (GO:0000387)2.45544059
123outer ear morphogenesis (GO:0042473)2.45210129
124central nervous system myelination (GO:0022010)2.43064808
125axon ensheathment in central nervous system (GO:0032291)2.43064808
126ribosomal large subunit biogenesis (GO:0042273)2.41785849
127negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.41747422
128pattern specification involved in kidney development (GO:0061004)2.41333527
129positive regulation of protein autophosphorylation (GO:0031954)2.40853547
130termination of RNA polymerase I transcription (GO:0006363)2.40733193
131negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.39356714
132cellular protein complex disassembly (GO:0043624)2.39338354
133notochord development (GO:0030903)2.39267641
134negative regulation of axon extension involved in axon guidance (GO:0048843)2.39209503
135ribosomal small subunit assembly (GO:0000028)2.38180022
136transcription elongation from RNA polymerase III promoter (GO:0006385)2.36435701
137termination of RNA polymerase III transcription (GO:0006386)2.36435701
138peptidyl-proline modification (GO:0018208)2.35557097
139L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.33520609
140UTP biosynthetic process (GO:0006228)2.30676145
141attachment of spindle microtubules to kinetochore (GO:0008608)2.30434159
142extracellular fibril organization (GO:0043206)2.30258661
143chondrocyte development (GO:0002063)2.30111466
144positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.29945946
145viral life cycle (GO:0019058)2.29702036
146transcription elongation from RNA polymerase I promoter (GO:0006362)2.29217022
147CENP-A containing nucleosome assembly (GO:0034080)2.29122618
148metanephric mesenchyme development (GO:0072075)2.28853144
149neuron fate determination (GO:0048664)2.27391497
150translational elongation (GO:0006414)2.26031032
151collagen fibril organization (GO:0030199)2.25555799
152negative regulation of embryonic development (GO:0045992)2.24807623
153regulation of oligodendrocyte differentiation (GO:0048713)2.24479564
154transcription-coupled nucleotide-excision repair (GO:0006283)2.24025313
155translational initiation (GO:0006413)2.22621505
156establishment of tissue polarity (GO:0007164)2.22022878
157establishment of planar polarity (GO:0001736)2.22022878
158mitotic metaphase plate congression (GO:0007080)2.20517203
159intraciliary transport (GO:0042073)2.20384453
160neural crest cell development (GO:0014032)2.20203732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.24912888
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.51352084
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.31911332
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.28168471
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.23028828
6* MYC_18555785_ChIP-Seq_MESCs_Mouse2.99561531
7* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.98617870
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.94582905
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62746387
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.55881126
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.42625966
12ELK1_19687146_ChIP-ChIP_HELA_Human2.41330761
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41295490
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33578002
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.28115725
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.21655043
17FUS_26573619_Chip-Seq_HEK293_Human2.19084514
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14509039
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09533975
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89456334
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88129745
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86356681
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85092373
24P300_19829295_ChIP-Seq_ESCs_Human1.84901103
25TAF15_26573619_Chip-Seq_HEK293_Human1.81034546
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.76194452
27MYC_18940864_ChIP-ChIP_HL60_Human1.70218439
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69866899
29E2F7_22180533_ChIP-Seq_HELA_Human1.69695856
30* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65596459
31XRN2_22483619_ChIP-Seq_HELA_Human1.65466325
32DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.59568756
33DCP1A_22483619_ChIP-Seq_HELA_Human1.57839419
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57805970
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57276715
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56696437
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55448374
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.53162576
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52441366
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.51540709
41SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50657515
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47735854
43* TTF2_22483619_ChIP-Seq_HELA_Human1.46943240
44* SOX17_20123909_ChIP-Seq_XEN_Mouse1.46250905
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46176597
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46109822
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43733729
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.43417131
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43321308
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42479164
51GBX2_23144817_ChIP-Seq_PC3_Human1.41224705
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39899164
53MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.37423077
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36227171
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35454867
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.35272218
57* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34824132
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33540806
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33318249
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32960168
61* NANOG_16153702_ChIP-ChIP_HESCs_Human1.32753759
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32162487
63EWS_26573619_Chip-Seq_HEK293_Human1.31278732
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30493471
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30068929
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28711028
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.28591360
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28503348
69* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28036113
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27241020
71* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24786404
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23727259
73AR_21909140_ChIP-Seq_LNCAP_Human1.21876748
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21681161
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21663119
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21281236
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19797392
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19579884
79IGF1R_20145208_ChIP-Seq_DFB_Human1.19313270
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17100912
81VDR_22108803_ChIP-Seq_LS180_Human1.15614204
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.14303771
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.13357215
84RNF2_27304074_Chip-Seq_NSC_Mouse1.12594097
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12484552
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11467228
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11372951
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.10589181
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10566477
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09347481
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.09274923
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08989709
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07102779
94* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06674801
95GABP_19822575_ChIP-Seq_HepG2_Human1.06080989
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05773606
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05246398
98JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05244591
99VDR_23849224_ChIP-Seq_CD4+_Human1.05019062
100* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04780126
101ZNF274_21170338_ChIP-Seq_K562_Hela1.04389208
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03962463
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03741864
104ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03406855
105FOXP3_21729870_ChIP-Seq_TREG_Human1.02980137
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02614694
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02357685
108* NANOG_19829295_ChIP-Seq_ESCs_Human1.02207864
109* SOX2_19829295_ChIP-Seq_ESCs_Human1.02207864
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01990007
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01736756
112TP63_19390658_ChIP-ChIP_HaCaT_Human1.01552203
113JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00878656
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00668826
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00305879
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99287360
117IRF1_19129219_ChIP-ChIP_H3396_Human0.98107850
118SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97063154
119* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95746496
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.95094858
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94929714
122EZH2_22144423_ChIP-Seq_EOC_Human0.94371257
123JUN_21703547_ChIP-Seq_K562_Human0.93995759
124* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93405118
125EP300_21415370_ChIP-Seq_HL-1_Mouse0.92644708
126SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92441222
127HTT_18923047_ChIP-ChIP_STHdh_Human0.92409341
128* SMAD4_21799915_ChIP-Seq_A2780_Human0.91933667
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.91825644
130EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91781254
131RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91781254
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91298321
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91298321
134SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91081835
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90942409
136CBP_20019798_ChIP-Seq_JUKART_Human0.90942409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.26865973
2MP0005503_abnormal_tendon_morphology3.18263008
3MP0010030_abnormal_orbit_morphology3.06951832
4MP0003122_maternal_imprinting2.77378103
5MP0009379_abnormal_foot_pigmentation2.56788574
6MP0008058_abnormal_DNA_repair2.30179917
7MP0003121_genomic_imprinting2.22999430
8MP0000049_abnormal_middle_ear2.07441390
9MP0003315_abnormal_perineum_morphology2.06970373
10MP0003123_paternal_imprinting2.06792012
11MP0009250_abnormal_appendicular_skeleto2.02389200
12MP0004272_abnormal_basement_membrane2.02303277
13MP0003941_abnormal_skin_development1.97977759
14MP0002837_dystrophic_cardiac_calcinosis1.88957429
15MP0003385_abnormal_body_wall1.87220498
16MP0010094_abnormal_chromosome_stability1.85278911
17MP0002938_white_spotting1.82479441
18MP0000372_irregular_coat_pigmentation1.78008450
19MP0005084_abnormal_gallbladder_morpholo1.74200042
20MP0001984_abnormal_olfaction1.72702053
21MP0003937_abnormal_limbs/digits/tail_de1.70922197
22MP0008932_abnormal_embryonic_tissue1.68671562
23MP0003942_abnormal_urinary_system1.67542284
24MP0005275_abnormal_skin_tensile1.67116914
25MP0003221_abnormal_cardiomyocyte_apopto1.65940294
26MP0002282_abnormal_trachea_morphology1.65721005
27MP0009384_cardiac_valve_regurgitation1.64943177
28MP0003567_abnormal_fetal_cardiomyocyte1.64044654
29MP0004133_heterotaxia1.60924005
30MP0002877_abnormal_melanocyte_morpholog1.60912878
31MP0005623_abnormal_meninges_morphology1.59233496
32MP0003755_abnormal_palate_morphology1.58839438
33MP0006072_abnormal_retinal_apoptosis1.54548461
34MP0000762_abnormal_tongue_morphology1.53311290
35MP0009053_abnormal_anal_canal1.52300210
36MP0003718_maternal_effect1.51568006
37MP0003787_abnormal_imprinting1.50004562
38MP0003283_abnormal_digestive_organ1.46222072
39MP0003186_abnormal_redox_activity1.40492749
40MP0003693_abnormal_embryo_hatching1.40302480
41MP0003119_abnormal_digestive_system1.40298614
42MP0005253_abnormal_eye_physiology1.39742416
43MP0003136_yellow_coat_color1.38714603
44MP0005508_abnormal_skeleton_morphology1.38260342
45MP0005394_taste/olfaction_phenotype1.38080125
46MP0005499_abnormal_olfactory_system1.38080125
47MP0003279_aneurysm1.35803021
48MP0002736_abnormal_nociception_after1.35473535
49MP0004957_abnormal_blastocyst_morpholog1.34647059
50MP0004215_abnormal_myocardial_fiber1.32846517
51MP0001299_abnormal_eye_distance/1.32016949
52MP0000537_abnormal_urethra_morphology1.31653208
53MP0003011_delayed_dark_adaptation1.26673401
54MP0005171_absent_coat_pigmentation1.25287260
55MP0010368_abnormal_lymphatic_system1.24048196
56MP0008995_early_reproductive_senescence1.24014184
57MP0002233_abnormal_nose_morphology1.22723342
58MP0000163_abnormal_cartilage_morphology1.20950170
59MP0002932_abnormal_joint_morphology1.20647733
60MP0000566_synostosis1.20156903
61MP0002249_abnormal_larynx_morphology1.19347673
62MP0003195_calcinosis1.18538235
63MP0002751_abnormal_autonomic_nervous1.13876607
64MP0002234_abnormal_pharynx_morphology1.12688758
65MP0006035_abnormal_mitochondrial_morpho1.11959171
66MP0003077_abnormal_cell_cycle1.11738319
67MP0008007_abnormal_cellular_replicative1.11719005
68MP0002177_abnormal_outer_ear1.10852103
69MP0002090_abnormal_vision1.10757228
70MP0008877_abnormal_DNA_methylation1.10081717
71MP0001286_abnormal_eye_development1.09651320
72MP0002697_abnormal_eye_size1.09280871
73MP0002009_preneoplasia1.07131933
74MP0002116_abnormal_craniofacial_bone1.06300726
75MP0001542_abnormal_bone_strength1.05838424
76MP0002163_abnormal_gland_morphology1.05730795
77MP0002295_abnormal_pulmonary_circulatio1.05489930
78MP0005551_abnormal_eye_electrophysiolog1.05431214
79MP0006036_abnormal_mitochondrial_physio1.03401375
80MP0001529_abnormal_vocalization1.03082608
81MP0001188_hyperpigmentation1.03049482
82MP0002084_abnormal_developmental_patter1.02904638
83MP0003890_abnormal_embryonic-extraembry1.02184985
84MP0002102_abnormal_ear_morphology1.01970116
85MP0004142_abnormal_muscle_tone1.01421871
86MP0000428_abnormal_craniofacial_morphol1.01129835
87MP0003111_abnormal_nucleus_morphology1.00819191
88MP0000631_abnormal_neuroendocrine_gland0.99652378
89MP0000778_abnormal_nervous_system0.99091364
90MP0003137_abnormal_impulse_conducting0.95803402
91MP0004134_abnormal_chest_morphology0.95680499
92MP0002111_abnormal_tail_morphology0.95459869
93MP0005187_abnormal_penis_morphology0.95138574
94MP0005391_vision/eye_phenotype0.94984707
95MP0006276_abnormal_autonomic_nervous0.94935096
96MP0000647_abnormal_sebaceous_gland0.94866049
97MP0003115_abnormal_respiratory_system0.94777257
98MP0003935_abnormal_craniofacial_develop0.94692756
99MP0008789_abnormal_olfactory_epithelium0.94395800
100MP0006054_spinal_hemorrhage0.92548166
101MP0000516_abnormal_urinary_system0.92211882
102MP0005367_renal/urinary_system_phenotyp0.92211882
103MP0002114_abnormal_axial_skeleton0.91349518
104MP0002085_abnormal_embryonic_tissue0.91285721
105MP0000432_abnormal_head_morphology0.90916098
106MP0003880_abnormal_central_pattern0.89357676
107MP0002896_abnormal_bone_mineralization0.88961860
108MP0000013_abnormal_adipose_tissue0.88574688
109MP0003938_abnormal_ear_development0.88320819
110MP0002108_abnormal_muscle_morphology0.87997608
111MP0002277_abnormal_respiratory_mucosa0.86689160
112MP0001485_abnormal_pinna_reflex0.85378384
113MP0000534_abnormal_ureter_morphology0.85191862
114MP0001879_abnormal_lymphatic_vessel0.84810614
115MP0004742_abnormal_vestibular_system0.84351426
116MP0010386_abnormal_urinary_bladder0.84016916
117MP0000678_abnormal_parathyroid_gland0.82866887
118MP0002160_abnormal_reproductive_system0.82082022
119MP0006292_abnormal_olfactory_placode0.81083969
120MP0002272_abnormal_nervous_system0.81029666
121MP0001340_abnormal_eyelid_morphology0.79933445
122MP0001293_anophthalmia0.79553627
123MP0003786_premature_aging0.78920929
124MP0001177_atelectasis0.78699480
125MP0005646_abnormal_pituitary_gland0.78330787
126MP0001905_abnormal_dopamine_level0.78284667
127MP0003861_abnormal_nervous_system0.77987541
128MP0002109_abnormal_limb_morphology0.77895672
129MP0001968_abnormal_touch/_nociception0.77256317
130MP0002638_abnormal_pupillary_reflex0.77105517
131MP0002752_abnormal_somatic_nervous0.76902486
132MP0005379_endocrine/exocrine_gland_phen0.76724889
133MP0005195_abnormal_posterior_eye0.76262912
134MP0009697_abnormal_copulation0.76145534
135MP0001486_abnormal_startle_reflex0.76125600
136MP0005257_abnormal_intraocular_pressure0.75092215
137MP0002115_abnormal_skeleton_extremities0.74488402
138MP0000026_abnormal_inner_ear0.74178074
139MP0002210_abnormal_sex_determination0.74076845
140MP0005595_abnormal_vascular_smooth0.73475704
141MP0001958_emphysema0.73327883
142MP0000653_abnormal_sex_gland0.71227291
143MP0001764_abnormal_homeostasis0.69714056
144MP0002184_abnormal_innervation0.69097647
145MP0009046_muscle_twitch0.67777954
146MP0001145_abnormal_male_reproductive0.67406153
147MP0004085_abnormal_heartbeat0.67093871

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.35550420
2Abnormal mitochondria in muscle tissue (HP:0008316)3.75742916
3Premature rupture of membranes (HP:0001788)3.65210559
4Progressive macrocephaly (HP:0004481)3.46068009
5Protrusio acetabuli (HP:0003179)3.43390447
6Abnormality of the labia minora (HP:0012880)3.32116737
7Abnormality of dentin (HP:0010299)3.29577460
8Colon cancer (HP:0003003)3.26562689
9Acute encephalopathy (HP:0006846)3.18400251
10Abnormality of glycolysis (HP:0004366)3.15412443
11Increased serum pyruvate (HP:0003542)3.15412443
12Mitochondrial inheritance (HP:0001427)3.14851033
13Methylmalonic acidemia (HP:0002912)3.07584821
14Soft skin (HP:0000977)2.60600700
15Abnormal hemoglobin (HP:0011902)2.60271638
16Increased CSF lactate (HP:0002490)2.58775283
17Decreased activity of mitochondrial respiratory chain (HP:0008972)2.55973433
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.55973433
19Congenital, generalized hypertrichosis (HP:0004540)2.54425875
20Medial flaring of the eyebrow (HP:0010747)2.53755054
21Hyperglycinemia (HP:0002154)2.50411853
22Methylmalonic aciduria (HP:0012120)2.47854701
23Abnormality of methionine metabolism (HP:0010901)2.45649881
24Cleft eyelid (HP:0000625)2.43708076
253-Methylglutaconic aciduria (HP:0003535)2.35492076
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33566060
27Intestinal atresia (HP:0011100)2.33492409
28Pancreatic cysts (HP:0001737)2.32000407
29Myelomeningocele (HP:0002475)2.30850988
30Bifid tongue (HP:0010297)2.28315756
31Hyperinsulinemic hypoglycemia (HP:0000825)2.27718389
32Congenital primary aphakia (HP:0007707)2.26291161
33Neonatal short-limb short stature (HP:0008921)2.22988661
34Abnormality of serum amino acid levels (HP:0003112)2.20868105
35Hypoglycemic coma (HP:0001325)2.19663123
36Gait imbalance (HP:0002141)2.18217076
37Increased hepatocellular lipid droplets (HP:0006565)2.17375735
38Hypoglycemic seizures (HP:0002173)2.16370885
39Abnormality of midbrain morphology (HP:0002418)2.16005807
40Molar tooth sign on MRI (HP:0002419)2.16005807
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.14259984
42Exercise intolerance (HP:0003546)2.13939458
43Hepatocellular necrosis (HP:0001404)2.12019361
44Optic disc pallor (HP:0000543)2.11502485
45Nephrogenic diabetes insipidus (HP:0009806)2.09472623
46Absent septum pellucidum (HP:0001331)2.09174994
47Lactic acidosis (HP:0003128)2.07168652
48Abnormality of the anterior horn cell (HP:0006802)2.06374187
49Degeneration of anterior horn cells (HP:0002398)2.06374187
50Leukodystrophy (HP:0002415)2.04433278
51Hypothermia (HP:0002045)2.04086852
52Medulloblastoma (HP:0002885)2.03589447
53Exertional dyspnea (HP:0002875)2.03041842
54Nephronophthisis (HP:0000090)2.01278331
55Increased serum lactate (HP:0002151)2.00599896
56Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99835797
57Hypoplastic pelvis (HP:0008839)1.99799839
58Adrenal hypoplasia (HP:0000835)1.97266264
59Morphological abnormality of the middle ear (HP:0008609)1.93494356
60Pancreatic islet-cell hyperplasia (HP:0004510)1.93467872
61Type I transferrin isoform profile (HP:0003642)1.92044584
62Meckel diverticulum (HP:0002245)1.91962000
63Glycosuria (HP:0003076)1.91644632
64Abnormality of urine glucose concentration (HP:0011016)1.91644632
65Abnormality of renal resorption (HP:0011038)1.91081286
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90635620
67Gastrointestinal atresia (HP:0002589)1.90447891
68Wormian bones (HP:0002645)1.90257192
69Megaloblastic anemia (HP:0001889)1.88454250
70Abnormality of vitamin B metabolism (HP:0004340)1.87244696
71Sclerocornea (HP:0000647)1.86976563
72Lipid accumulation in hepatocytes (HP:0006561)1.86825807
73Secondary amenorrhea (HP:0000869)1.86772354
74Aplasia/Hypoplasia of the uvula (HP:0010293)1.86344083
75Short tibia (HP:0005736)1.86147353
76Volvulus (HP:0002580)1.85000335
77Optic nerve hypoplasia (HP:0000609)1.84872897
78Hepatoblastoma (HP:0002884)1.84655113
79Anencephaly (HP:0002323)1.84443222
80Increased intramyocellular lipid droplets (HP:0012240)1.83702022
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82573388
82Abnormality of the ileum (HP:0001549)1.82504238
83Renal Fanconi syndrome (HP:0001994)1.82413131
84Triphalangeal thumb (HP:0001199)1.82359863
85X-linked dominant inheritance (HP:0001423)1.82237057
86Abnormality of the phalanges of the 2nd finger (HP:0009541)1.81858772
87Stenosis of the external auditory canal (HP:0000402)1.81828795
88Coronal craniosynostosis (HP:0004440)1.81380716
89Cerebral edema (HP:0002181)1.81334936
90Aplasia/hypoplasia of the uterus (HP:0008684)1.80869907
91Porencephaly (HP:0002132)1.80594367
92Hepatic necrosis (HP:0002605)1.80144567
93Lethargy (HP:0001254)1.78993461
94Short 5th finger (HP:0009237)1.78083627
95Infantile muscular hypotonia (HP:0008947)1.77538577
96Hemivertebrae (HP:0002937)1.77401091
97True hermaphroditism (HP:0010459)1.77176036
98Shallow orbits (HP:0000586)1.76047364
99Abnormal lung lobation (HP:0002101)1.75878954
100Down-sloping shoulders (HP:0200021)1.75592062
101Respiratory failure (HP:0002878)1.75183220
102Abnormality of chromosome stability (HP:0003220)1.75068257
103Abnormality of the vitamin B12 metabolism (HP:0004341)1.74990866
104Median cleft lip (HP:0000161)1.74650587
105Biconcave vertebral bodies (HP:0004586)1.74276849
106Abnormality of the septum pellucidum (HP:0007375)1.74217388
107Abnormal protein glycosylation (HP:0012346)1.73817118
108Abnormal glycosylation (HP:0012345)1.73817118
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73817118
110Abnormal protein N-linked glycosylation (HP:0012347)1.73817118
111Anophthalmia (HP:0000528)1.73662187
112Embryonal renal neoplasm (HP:0011794)1.72566614
113Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.72054202
114Abnormal number of erythroid precursors (HP:0012131)1.72030421
115Respiratory difficulties (HP:0002880)1.71842584
116Abnormality of serine family amino acid metabolism (HP:0010894)1.71709436
117Abnormality of glycine metabolism (HP:0010895)1.71709436
118Wide anterior fontanel (HP:0000260)1.71708304
119Bilateral microphthalmos (HP:0007633)1.70042189
120Abnormality of the nasolacrimal system (HP:0000614)1.69764007
121Missing ribs (HP:0000921)1.69506236
122Long nose (HP:0003189)1.69116689
123Hyperphosphaturia (HP:0003109)1.67519846
124Delayed cranial suture closure (HP:0000270)1.67397548
125Gonadotropin excess (HP:0000837)1.67328409
126Irregular epiphyses (HP:0010582)1.67015740
127Reticulocytopenia (HP:0001896)1.66486823
128Aplasia/Hypoplasia of the tibia (HP:0005772)1.66440751
129Esophageal atresia (HP:0002032)1.66219164
130Spinal rigidity (HP:0003306)1.65813439
131Abnormality of the parietal bone (HP:0002696)1.62896413
132Vaginal atresia (HP:0000148)1.62380569
133Genital tract atresia (HP:0001827)1.62302628
134Aplasia involving bones of the extremities (HP:0009825)1.62259233
135Aplasia involving bones of the upper limbs (HP:0009823)1.62259233
136Aplasia of the phalanges of the hand (HP:0009802)1.62259233
137Thickened helices (HP:0000391)1.61586303
138Hepatosplenomegaly (HP:0001433)1.60867127
139Supernumerary spleens (HP:0009799)1.60250694
140Metaphyseal dysplasia (HP:0100255)1.60147882
141Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.59102942
142Partial duplication of the phalanx of hand (HP:0009999)1.57736974
143Holoprosencephaly (HP:0001360)1.56592257
144Cupped ear (HP:0000378)1.56502099
145Aortic dissection (HP:0002647)1.56045268
146Fibular aplasia (HP:0002990)1.54341042
147Epiphyseal dysplasia (HP:0002656)1.53969415
148Short middle phalanx of the 5th finger (HP:0004220)1.52619442
149Abnormality of the 2nd finger (HP:0004100)1.52374189
150Neuroendocrine neoplasm (HP:0100634)1.51502458
151Septo-optic dysplasia (HP:0100842)1.51011251
152Renal hypoplasia (HP:0000089)1.50968666
153Decreased subcutaneous fat (HP:0001002)1.50064760
154Delayed gross motor development (HP:0002194)1.49977086
155Progressive microcephaly (HP:0000253)1.49111937
156Pheochromocytoma (HP:0002666)1.48917389
157Nephroblastoma (Wilms tumor) (HP:0002667)1.48754295
158Glossoptosis (HP:0000162)1.47750083
159Abnormality of the fetal cardiovascular system (HP:0010948)1.46837943
160Abnormal umbilical cord blood vessels (HP:0011403)1.46837943
161Single umbilical artery (HP:0001195)1.46837943
162Cutaneous finger syndactyly (HP:0010554)1.45767879
163Vertebral compression fractures (HP:0002953)1.45543330
164Fused cervical vertebrae (HP:0002949)1.44354988
165Pancreatic fibrosis (HP:0100732)1.43845418
166Broad toe (HP:0001837)1.41812350
167Alacrima (HP:0000522)1.41566627
168Atrophic scars (HP:0001075)1.41460749
169Macrocytic anemia (HP:0001972)1.41400644

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LIMK12.80754949
2BCR2.72909449
3BUB12.72745727
4VRK22.71190521
5MAP3K42.69983349
6PBK2.63513769
7MKNK12.59797425
8MAP2K72.54288280
9TNIK2.53708015
10EIF2AK12.42579363
11CASK2.36910150
12MAP3K62.36056211
13MKNK22.20826236
14TRIM282.20752566
15NEK12.02295020
16TESK12.00306671
17LATS21.96453615
18EIF2AK31.77356789
19MAP4K21.67225886
20PLK21.58681666
21NME21.58560282
22TAF11.55982259
23ERBB31.52389670
24TESK21.50352458
25STK391.42952073
26MAP3K121.36163275
27CDK141.35444440
28BCKDK1.33443451
29MYLK1.30089722
30MAP2K41.26905335
31DDR21.26869182
32STK38L1.26615630
33DYRK21.24383823
34UHMK11.23989222
35CSNK1G31.22532068
36CDK181.22236167
37EPHB21.20410221
38PASK1.20122504
39PLK31.19463115
40BMPR1B1.18389636
41FRK1.18193201
42CDK151.17671533
43GRK11.16606190
44ADRBK11.14952396
45WNK41.14349807
46NME11.13568894
47CDK11A1.10380438
48SRPK11.10375301
49CDC71.09048333
50LATS11.08310576
51CDK81.07283434
52VRK11.07053909
53FER1.03650138
54PAK31.00402267
55ADRBK21.00139915
56DYRK30.99894371
57CSNK1A1L0.99661150
58TIE10.97612898
59CDK60.95568131
60STK160.92571933
61OXSR10.90330728
62OBSCN0.89983967
63CSNK1G10.89240820
64PIK3CA0.88674671
65TGFBR10.87970201
66WEE10.85941271
67YES10.82147436
68PLK40.79391766
69CSNK1G20.79106752
70EPHA40.78661378
71ABL20.78313619
72CHEK20.76950262
73MINK10.75231980
74PINK10.74802735
75MET0.74635837
76STK30.74515863
77WNK30.73767851
78TLK10.73438857
79PRKCG0.72984344
80AURKB0.72892353
81ERBB40.72835283
82PTK2B0.71817700
83PAK40.70297750
84BRSK10.69942293
85PAK20.69857584
86PNCK0.69733429
87NUAK10.69681590
88FGFR20.69255751
89INSRR0.69209119
90EIF2AK20.68821114
91CDK30.66952838
92ILK0.63646852
93PAK10.63385985
94BRAF0.62984665
95NLK0.62264295
96ROCK20.61745610
97PDK20.60194728
98ROCK10.59893149
99MOS0.59334682
100MAP3K50.57354550
101AURKA0.56594837
102FGFR10.56276081
103CSNK2A10.53712297
104MAPK130.53323047
105CDK190.52345714
106RPS6KA40.52198142
107PRPF4B0.51700639
108PLK10.51700138
109PRKCE0.51430634
110BRSK20.50617122
111MST40.50208586
112ZAK0.50170438
113CDK90.50168598
114NEK60.46447632
115ATM0.46418206
116ATR0.46411545
117FLT30.45206883
118DAPK30.44408331
119PIK3CG0.43865037
120NEK20.43849010
121CSNK1E0.43836762
122TTK0.43224373
123CSNK2A20.43128867
124PIM20.41552224
125WNK10.40488138
126ACVR1B0.40031706
127TSSK60.39609717
128RPS6KA50.38522242
129CAMK2A0.38023598
130STK40.37107147
131ALK0.30715821
132CSNK1A10.29932107
133DMPK0.28840106
134STK240.28674713
135MAPK150.28256391
136TEC0.26477876

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.33799170
2Oxidative phosphorylation_Homo sapiens_hsa001903.58507953
3Ribosome_Homo sapiens_hsa030103.48346786
4Proteasome_Homo sapiens_hsa030503.23159916
5Parkinsons disease_Homo sapiens_hsa050123.12916143
6DNA replication_Homo sapiens_hsa030302.69339671
7RNA polymerase_Homo sapiens_hsa030202.60750558
8Huntingtons disease_Homo sapiens_hsa050162.37097803
9Alzheimers disease_Homo sapiens_hsa050102.35325825
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22862389
11Nucleotide excision repair_Homo sapiens_hsa034202.21538278
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19955913
13Propanoate metabolism_Homo sapiens_hsa006402.10349292
14Mismatch repair_Homo sapiens_hsa034302.04768607
15Spliceosome_Homo sapiens_hsa030402.01827561
16Cell cycle_Homo sapiens_hsa041101.68033121
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66501235
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64221857
19Cardiac muscle contraction_Homo sapiens_hsa042601.61323271
20Basal transcription factors_Homo sapiens_hsa030221.60777543
21Vibrio cholerae infection_Homo sapiens_hsa051101.59958299
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51736202
23Homologous recombination_Homo sapiens_hsa034401.48706731
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48616507
25RNA transport_Homo sapiens_hsa030131.40359737
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.37006136
27Sulfur metabolism_Homo sapiens_hsa009201.35168541
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34558893
29Hedgehog signaling pathway_Homo sapiens_hsa043401.34470860
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31348472
31ECM-receptor interaction_Homo sapiens_hsa045121.26157801
32Pyrimidine metabolism_Homo sapiens_hsa002401.25176268
33Butanoate metabolism_Homo sapiens_hsa006501.22765233
34Basal cell carcinoma_Homo sapiens_hsa052171.22566586
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18083786
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17173771
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.15416360
38Selenocompound metabolism_Homo sapiens_hsa004501.15242880
39Steroid biosynthesis_Homo sapiens_hsa001001.13651934
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11638207
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09004496
42Fatty acid elongation_Homo sapiens_hsa000621.08516878
43Hippo signaling pathway_Homo sapiens_hsa043901.05753949
44TGF-beta signaling pathway_Homo sapiens_hsa043500.98187656
45Oocyte meiosis_Homo sapiens_hsa041140.96535404
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94192449
47Glutathione metabolism_Homo sapiens_hsa004800.93924627
48Peroxisome_Homo sapiens_hsa041460.90555296
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90160917
50Axon guidance_Homo sapiens_hsa043600.89152838
51Purine metabolism_Homo sapiens_hsa002300.87452149
52Vitamin B6 metabolism_Homo sapiens_hsa007500.87067245
53mRNA surveillance pathway_Homo sapiens_hsa030150.85673588
54RNA degradation_Homo sapiens_hsa030180.85008215
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83976407
56Wnt signaling pathway_Homo sapiens_hsa043100.83238470
57Alcoholism_Homo sapiens_hsa050340.80561415
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78995672
59Tight junction_Homo sapiens_hsa045300.78188347
60Serotonergic synapse_Homo sapiens_hsa047260.78087038
61Base excision repair_Homo sapiens_hsa034100.78082836
62Nicotine addiction_Homo sapiens_hsa050330.78043996
63Bladder cancer_Homo sapiens_hsa052190.78017509
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76988190
65Melanoma_Homo sapiens_hsa052180.75019590
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71641532
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69933885
68Collecting duct acid secretion_Homo sapiens_hsa049660.69799603
69Long-term depression_Homo sapiens_hsa047300.68955147
70Non-homologous end-joining_Homo sapiens_hsa034500.68245207
71Tryptophan metabolism_Homo sapiens_hsa003800.66625975
72Focal adhesion_Homo sapiens_hsa045100.65228474
73Protein digestion and absorption_Homo sapiens_hsa049740.64859152
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64766248
75Arachidonic acid metabolism_Homo sapiens_hsa005900.64701391
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.64451729
77N-Glycan biosynthesis_Homo sapiens_hsa005100.64260103
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63780891
79Dilated cardiomyopathy_Homo sapiens_hsa054140.62853225
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62365884
81Carbon metabolism_Homo sapiens_hsa012000.60088943
82Epstein-Barr virus infection_Homo sapiens_hsa051690.59070227
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57495270
84Fatty acid metabolism_Homo sapiens_hsa012120.57349841
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57252249
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56619269
87p53 signaling pathway_Homo sapiens_hsa041150.56203693
88Sphingolipid metabolism_Homo sapiens_hsa006000.56164448
89Dopaminergic synapse_Homo sapiens_hsa047280.56138477
90Fatty acid degradation_Homo sapiens_hsa000710.54740458
91Pyruvate metabolism_Homo sapiens_hsa006200.54568552
92Retinol metabolism_Homo sapiens_hsa008300.53162684
93Phagosome_Homo sapiens_hsa041450.53016515
94Melanogenesis_Homo sapiens_hsa049160.52876249
95Systemic lupus erythematosus_Homo sapiens_hsa053220.52473855
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51911981
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51632417
98Ether lipid metabolism_Homo sapiens_hsa005650.51343694
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51034209
100Regulation of autophagy_Homo sapiens_hsa041400.49668003
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49193243
102beta-Alanine metabolism_Homo sapiens_hsa004100.49025454
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48712057
104Vitamin digestion and absorption_Homo sapiens_hsa049770.47991567
105Biosynthesis of amino acids_Homo sapiens_hsa012300.47833976
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47519440
107Chemical carcinogenesis_Homo sapiens_hsa052040.46275249
108Arginine and proline metabolism_Homo sapiens_hsa003300.45506889
109Metabolic pathways_Homo sapiens_hsa011000.43012030
110Phototransduction_Homo sapiens_hsa047440.39957476
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39313281
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38092294
113Linoleic acid metabolism_Homo sapiens_hsa005910.38091882
114GABAergic synapse_Homo sapiens_hsa047270.38046708
115Taste transduction_Homo sapiens_hsa047420.37687351
116Nitrogen metabolism_Homo sapiens_hsa009100.37499297
117Cocaine addiction_Homo sapiens_hsa050300.37106510
118Caffeine metabolism_Homo sapiens_hsa002320.35590719
119MicroRNAs in cancer_Homo sapiens_hsa052060.35472191
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35309132
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35294732
122Tyrosine metabolism_Homo sapiens_hsa003500.35219534
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35219346
124Fanconi anemia pathway_Homo sapiens_hsa034600.35174202
125Malaria_Homo sapiens_hsa051440.34627205
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34429010
127Adherens junction_Homo sapiens_hsa045200.33789477
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33786383
129Folate biosynthesis_Homo sapiens_hsa007900.33527573
130Gap junction_Homo sapiens_hsa045400.33422826
131Amphetamine addiction_Homo sapiens_hsa050310.31498120
132Sulfur relay system_Homo sapiens_hsa041220.31371601
133Pathways in cancer_Homo sapiens_hsa052000.30948094
134Proteoglycans in cancer_Homo sapiens_hsa052050.30851633
135Viral carcinogenesis_Homo sapiens_hsa052030.29843370
136One carbon pool by folate_Homo sapiens_hsa006700.28003098
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27198806
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26867358
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.26292940
140Fat digestion and absorption_Homo sapiens_hsa049750.25452338

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