TCEAL9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein. This gene also encodes a domain with similarity to the transcription elongation factor A, SII-related family. Alternative splicing results in multiple transcript variants encoding a single isoform. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.08643897
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.61771926
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.30848002
4ATP synthesis coupled proton transport (GO:0015986)4.30848002
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02118694
6proteasome assembly (GO:0043248)3.80588273
7chaperone-mediated protein transport (GO:0072321)3.71076987
8protein neddylation (GO:0045116)3.55030288
9respiratory electron transport chain (GO:0022904)3.46716139
10chromatin remodeling at centromere (GO:0031055)3.44913904
11electron transport chain (GO:0022900)3.39447619
12CENP-A containing nucleosome assembly (GO:0034080)3.37576601
13sequestering of actin monomers (GO:0042989)3.29586464
14cotranslational protein targeting to membrane (GO:0006613)3.06035772
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.03405138
16limb bud formation (GO:0060174)3.03035630
17regulation of mesoderm development (GO:2000380)3.01815620
18neuron fate determination (GO:0048664)2.98090689
19protein targeting to ER (GO:0045047)2.96560711
20protein complex biogenesis (GO:0070271)2.93254169
21DNA damage response, detection of DNA damage (GO:0042769)2.92739971
22establishment of protein localization to endoplasmic reticulum (GO:0072599)2.86638521
23mitochondrial respiratory chain complex assembly (GO:0033108)2.86552083
24mitochondrial respiratory chain complex I assembly (GO:0032981)2.86256952
25NADH dehydrogenase complex assembly (GO:0010257)2.86256952
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86256952
27translational termination (GO:0006415)2.85027613
28establishment of integrated proviral latency (GO:0075713)2.84452972
29primitive streak formation (GO:0090009)2.84378898
30histone exchange (GO:0043486)2.83671672
31viral transcription (GO:0019083)2.83292247
32positive regulation of gastrulation (GO:2000543)2.81483789
33protein localization to endoplasmic reticulum (GO:0070972)2.77578417
34ribosomal small subunit assembly (GO:0000028)2.73619707
35ribosomal large subunit biogenesis (GO:0042273)2.72693253
36negative regulation of axon guidance (GO:1902668)2.71256164
37somite rostral/caudal axis specification (GO:0032525)2.69780756
38anterior/posterior axis specification (GO:0009948)2.63001783
39ventricular cardiac muscle cell development (GO:0055015)2.61854465
40negative regulation of axon extension involved in axon guidance (GO:0048843)2.60650930
41cullin deneddylation (GO:0010388)2.56502418
42anterior/posterior axis specification, embryo (GO:0008595)2.51557449
43lateral sprouting from an epithelium (GO:0060601)2.51164454
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.49083318
45protein-cofactor linkage (GO:0018065)2.48377154
46regulation of mitochondrial translation (GO:0070129)2.48318143
47DNA replication-independent nucleosome organization (GO:0034724)2.46701834
48DNA replication-independent nucleosome assembly (GO:0006336)2.46701834
49transcription elongation from RNA polymerase III promoter (GO:0006385)2.43027433
50termination of RNA polymerase III transcription (GO:0006386)2.43027433
51maturation of SSU-rRNA (GO:0030490)2.42826139
52platelet dense granule organization (GO:0060155)2.42083150
53otic vesicle formation (GO:0030916)2.38045148
54intraciliary transport (GO:0042073)2.37783656
55inner mitochondrial membrane organization (GO:0007007)2.36696334
56translation (GO:0006412)2.36208179
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.35080527
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.35052317
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.32592620
60sequestering of extracellular ligand from receptor (GO:0035581)2.30471909
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.30155599
62protein deneddylation (GO:0000338)2.29883515
63paraxial mesoderm development (GO:0048339)2.28930085
64ATP biosynthetic process (GO:0006754)2.28166908
65translational initiation (GO:0006413)2.27914613
66translational elongation (GO:0006414)2.26403530
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.26304596
68negative regulation of ligase activity (GO:0051352)2.26304596
69presynaptic membrane assembly (GO:0097105)2.26264874
70female gonad development (GO:0008585)2.24848980
71nonmotile primary cilium assembly (GO:0035058)2.24484653
72purine nucleoside triphosphate biosynthetic process (GO:0009145)2.24126831
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.23992357
74respiratory chain complex IV assembly (GO:0008535)2.23413459
75regulation of timing of cell differentiation (GO:0048505)2.23230878
76establishment of viral latency (GO:0019043)2.22979500
77spliceosomal snRNP assembly (GO:0000387)2.22704364
78purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.22222901
79retinal ganglion cell axon guidance (GO:0031290)2.22174727
80regulation of development, heterochronic (GO:0040034)2.21867438
81intracellular protein transmembrane import (GO:0044743)2.21083277
82axon extension involved in axon guidance (GO:0048846)2.20497915
83neuron projection extension involved in neuron projection guidance (GO:1902284)2.20497915
84kinetochore assembly (GO:0051382)2.20047943
85regulation of gastrulation (GO:0010470)2.19687923
86hydrogen ion transmembrane transport (GO:1902600)2.18803194
87kinetochore organization (GO:0051383)2.17900744
887-methylguanosine mRNA capping (GO:0006370)2.15969234
89kidney morphogenesis (GO:0060993)2.15287302
90cellular protein complex disassembly (GO:0043624)2.14645322
91protein localization to mitochondrion (GO:0070585)2.12653151
92viral life cycle (GO:0019058)2.12459399
93DNA replication checkpoint (GO:0000076)2.11679397
94ribosomal small subunit biogenesis (GO:0042274)2.11278540
95signal transduction involved in regulation of gene expression (GO:0023019)2.10751564
967-methylguanosine RNA capping (GO:0009452)2.10147836
97RNA capping (GO:0036260)2.10147836
98mesenchymal to epithelial transition (GO:0060231)2.08812202
99protein peptidyl-prolyl isomerization (GO:0000413)2.08757809
100pattern specification involved in kidney development (GO:0061004)2.08514593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62697359
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.19016497
3EST1_17652178_ChIP-ChIP_JURKAT_Human2.91536944
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55451775
5ELK1_19687146_ChIP-ChIP_HELA_Human2.50188615
6CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36736051
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32539200
8FUS_26573619_Chip-Seq_HEK293_Human2.22774460
9EWS_26573619_Chip-Seq_HEK293_Human2.18076806
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06259475
11POU5F1_16153702_ChIP-ChIP_HESCs_Human2.01590750
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95590666
13ZNF274_21170338_ChIP-Seq_K562_Hela1.90495554
14MYC_18555785_ChIP-Seq_MESCs_Mouse1.87888074
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.87474300
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86725031
17VDR_22108803_ChIP-Seq_LS180_Human1.79828491
18P300_19829295_ChIP-Seq_ESCs_Human1.79805828
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.71986376
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68652830
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.66390594
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64590181
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64025337
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62420268
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.62298291
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58725849
27NANOG_16153702_ChIP-ChIP_HESCs_Human1.57672604
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57648473
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56590845
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.55395634
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54823559
32TAF15_26573619_Chip-Seq_HEK293_Human1.51885840
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.51830588
34MYC_18940864_ChIP-ChIP_HL60_Human1.49185232
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47875534
36GBX2_23144817_ChIP-Seq_PC3_Human1.43368264
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42661318
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41835612
39AR_21909140_ChIP-Seq_LNCAP_Human1.40001325
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.38631169
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37575348
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.34564430
43SOX2_16153702_ChIP-ChIP_HESCs_Human1.34182926
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32510872
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31319042
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.31158931
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30990207
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.30468108
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30060426
50RNF2_27304074_Chip-Seq_NSC_Mouse1.27998644
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.26983635
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26498287
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26028738
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25399816
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25017756
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24922501
57TTF2_22483619_ChIP-Seq_HELA_Human1.23924625
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19210367
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18933828
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18913366
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17876557
62VDR_23849224_ChIP-Seq_CD4+_Human1.16654075
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16037227
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15028481
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14795767
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14356238
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13332264
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13057941
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12868215
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11665754
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10474095
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09327108
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08928482
74DCP1A_22483619_ChIP-Seq_HELA_Human1.08675536
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.08641453
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.08624510
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03849839
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03348846
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03194809
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03019927
81SOX17_20123909_ChIP-Seq_XEN_Mouse1.02700540
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02275431
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01831825
84SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00598803
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00510243
86MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98544816
87NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96939690
88IGF1R_20145208_ChIP-Seq_DFB_Human0.96784537
89THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95764909
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95705529
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95695868
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95327467
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95327467
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95327467
95EOMES_21245162_ChIP-Seq_HESCs_Human0.94677319
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94648095
97TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94157891
98TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93242856
99TP53_18474530_ChIP-ChIP_U2OS_Human0.92537774
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91969789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.43736899
2MP0010030_abnormal_orbit_morphology3.11628311
3MP0003890_abnormal_embryonic-extraembry2.78316053
4MP0002938_white_spotting2.36160430
5MP0003283_abnormal_digestive_organ2.30870001
6MP0004272_abnormal_basement_membrane2.21909252
7MP0006054_spinal_hemorrhage1.98562052
8MP0001293_anophthalmia1.89226170
9MP0003119_abnormal_digestive_system1.84107301
10MP0006292_abnormal_olfactory_placode1.83842001
11MP0003937_abnormal_limbs/digits/tail_de1.83416534
12MP0009379_abnormal_foot_pigmentation1.83095478
13MP0004133_heterotaxia1.81884918
14MP0000049_abnormal_middle_ear1.81876286
15MP0008438_abnormal_cutaneous_collagen1.80668975
16MP0006072_abnormal_retinal_apoptosis1.78340145
17MP0001529_abnormal_vocalization1.66395829
18MP0002102_abnormal_ear_morphology1.63847420
19MP0003941_abnormal_skin_development1.57914822
20MP0005503_abnormal_tendon_morphology1.51596936
21MP0008789_abnormal_olfactory_epithelium1.50942650
22MP0002233_abnormal_nose_morphology1.50486433
23MP0001299_abnormal_eye_distance/1.49108715
24MP0010368_abnormal_lymphatic_system1.47448486
25MP0002282_abnormal_trachea_morphology1.47417690
26MP0002234_abnormal_pharynx_morphology1.46826517
27MP0005187_abnormal_penis_morphology1.46594665
28MP0009250_abnormal_appendicular_skeleto1.46300576
29MP0003880_abnormal_central_pattern1.46166616
30MP0001286_abnormal_eye_development1.44863250
31MP0005084_abnormal_gallbladder_morpholo1.42022859
32MP0002697_abnormal_eye_size1.41440433
33MP0000566_synostosis1.38888737
34MP0003755_abnormal_palate_morphology1.33981631
35MP0005499_abnormal_olfactory_system1.33903807
36MP0005394_taste/olfaction_phenotype1.33903807
37MP0000372_irregular_coat_pigmentation1.31437140
38MP0000762_abnormal_tongue_morphology1.31436589
39MP0003385_abnormal_body_wall1.31309303
40MP0001879_abnormal_lymphatic_vessel1.30691585
41MP0008058_abnormal_DNA_repair1.30624144
42MP0008932_abnormal_embryonic_tissue1.30195787
43MP0005171_absent_coat_pigmentation1.28452032
44MP0003186_abnormal_redox_activity1.28368161
45MP0005257_abnormal_intraocular_pressure1.26834258
46MP0009053_abnormal_anal_canal1.26496042
47MP0009697_abnormal_copulation1.24649910
48MP0003942_abnormal_urinary_system1.21299782
49MP0000537_abnormal_urethra_morphology1.20704189
50MP0000647_abnormal_sebaceous_gland1.20528848
51MP0000778_abnormal_nervous_system1.19753930
52MP0000631_abnormal_neuroendocrine_gland1.18235562
53MP0002736_abnormal_nociception_after1.17700829
54MP0001485_abnormal_pinna_reflex1.15818412
55MP0000516_abnormal_urinary_system1.15612831
56MP0005367_renal/urinary_system_phenotyp1.15612831
57MP0003315_abnormal_perineum_morphology1.15459733
58MP0002295_abnormal_pulmonary_circulatio1.13150734
59MP0003122_maternal_imprinting1.13088785
60MP0001984_abnormal_olfaction1.11719805
61MP0003011_delayed_dark_adaptation1.07836534
62MP0003195_calcinosis1.04902100
63MP0005275_abnormal_skin_tensile1.04532831
64MP0003279_aneurysm1.03267465
65MP0003121_genomic_imprinting1.00664069
66MP0004957_abnormal_blastocyst_morpholog1.00642598
67MP0002111_abnormal_tail_morphology1.00448465
68MP0003935_abnormal_craniofacial_develop1.00275426
69MP0005391_vision/eye_phenotype0.99654608
70MP0002084_abnormal_developmental_patter0.99209290
71MP0002653_abnormal_ependyma_morphology0.99011247
72MP0005253_abnormal_eye_physiology0.98560868
73MP0004215_abnormal_myocardial_fiber0.97939026
74MP0002837_dystrophic_cardiac_calcinosis0.96099217
75MP0000026_abnormal_inner_ear0.95457018
76MP0000428_abnormal_craniofacial_morphol0.95302422
77MP0000534_abnormal_ureter_morphology0.94635490
78MP0003567_abnormal_fetal_cardiomyocyte0.94393807
79MP0003718_maternal_effect0.94378139
80MP0005508_abnormal_skeleton_morphology0.92217096
81MP0002638_abnormal_pupillary_reflex0.92132527
82MP0002751_abnormal_autonomic_nervous0.91561777
83MP0006276_abnormal_autonomic_nervous0.89620080
84MP0009384_cardiac_valve_regurgitation0.89559839
85MP0005197_abnormal_uvea_morphology0.87669011
86MP0002085_abnormal_embryonic_tissue0.86870962
87MP0010094_abnormal_chromosome_stability0.86417366
88MP0002092_abnormal_eye_morphology0.86218883
89MP0003938_abnormal_ear_development0.85394243
90MP0005623_abnormal_meninges_morphology0.84984352
91MP0002109_abnormal_limb_morphology0.81494079
92MP0000462_abnormal_digestive_system0.81364236
93MP0002932_abnormal_joint_morphology0.80688171
94MP0002090_abnormal_vision0.79659183
95MP0005195_abnormal_posterior_eye0.79323401
96MP0002116_abnormal_craniofacial_bone0.78602272
97MP0005551_abnormal_eye_electrophysiolog0.75930175
98MP0000432_abnormal_head_morphology0.75614794
99MP0004142_abnormal_muscle_tone0.74939959
100MP0003861_abnormal_nervous_system0.74448651

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.61520947
2Septo-optic dysplasia (HP:0100842)3.38010721
3Acute encephalopathy (HP:0006846)3.07478068
4Abnormal mitochondria in muscle tissue (HP:0008316)3.06100993
5Mitochondrial inheritance (HP:0001427)3.02809186
6Progressive macrocephaly (HP:0004481)3.01482173
7Increased hepatocellular lipid droplets (HP:0006565)2.99891603
8Congenital, generalized hypertrichosis (HP:0004540)2.91959915
9Anophthalmia (HP:0000528)2.69842615
10True hermaphroditism (HP:0010459)2.68785064
11Increased CSF lactate (HP:0002490)2.68232091
12Pancreatic fibrosis (HP:0100732)2.62791308
13Lipid accumulation in hepatocytes (HP:0006561)2.57407876
14Renal Fanconi syndrome (HP:0001994)2.55041849
15Bifid tongue (HP:0010297)2.37731719
16Absent septum pellucidum (HP:0001331)2.35617013
17Medial flaring of the eyebrow (HP:0010747)2.29630733
18Pancreatic cysts (HP:0001737)2.27468335
19Abnormality of midbrain morphology (HP:0002418)2.22046992
20Molar tooth sign on MRI (HP:0002419)2.22046992
21Hepatocellular necrosis (HP:0001404)2.21420836
22Cerebral edema (HP:0002181)2.21115335
23Vaginal atresia (HP:0000148)2.19742136
24Genital tract atresia (HP:0001827)2.18650065
25Sclerocornea (HP:0000647)2.17011110
26Hypoplastic pelvis (HP:0008839)2.12143673
27Hepatic necrosis (HP:0002605)2.10633785
28Macrocytic anemia (HP:0001972)2.10412028
29Reticulocytopenia (HP:0001896)2.08512666
30Congenital primary aphakia (HP:0007707)2.07177217
31Esophageal atresia (HP:0002032)2.04733424
32Intestinal atresia (HP:0011100)2.01542674
33Premature rupture of membranes (HP:0001788)2.00428907
34Gastrointestinal atresia (HP:0002589)2.00272800
35Abnormality of the fetal cardiovascular system (HP:0010948)1.99666802
36Abnormal umbilical cord blood vessels (HP:0011403)1.99666802
37Single umbilical artery (HP:0001195)1.99666802
38Abnormality of the labia minora (HP:0012880)1.98073645
39Gait imbalance (HP:0002141)1.97206377
40Maternal diabetes (HP:0009800)1.96939988
41Stenosis of the external auditory canal (HP:0000402)1.96518566
42Abnormal number of erythroid precursors (HP:0012131)1.96255318
43Aplasia/Hypoplasia of the tongue (HP:0010295)1.95986871
443-Methylglutaconic aciduria (HP:0003535)1.95160645
45Colon cancer (HP:0003003)1.94202734
46Delayed gross motor development (HP:0002194)1.93244517
47Exertional dyspnea (HP:0002875)1.93124410
48Bilateral microphthalmos (HP:0007633)1.92040151
49Optic nerve hypoplasia (HP:0000609)1.88730223
50Short tibia (HP:0005736)1.88529749
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88235929
52Nephronophthisis (HP:0000090)1.88229243
53Increased serum pyruvate (HP:0003542)1.87364682
54Abnormality of the septum pellucidum (HP:0007375)1.86131889
55Rib fusion (HP:0000902)1.85507416
56Abdominal situs inversus (HP:0003363)1.84091586
57Abnormality of abdominal situs (HP:0011620)1.84091586
58Abnormality of cells of the erythroid lineage (HP:0012130)1.83395017
59Supernumerary spleens (HP:0009799)1.79774542
60Abnormality of the middle phalanges of the toes (HP:0010183)1.78836996
61Short hallux (HP:0010109)1.78637926
62Preaxial foot polydactyly (HP:0001841)1.78490405
63Anencephaly (HP:0002323)1.78304443
64Nephrogenic diabetes insipidus (HP:0009806)1.78257649
65Partial duplication of the phalanx of hand (HP:0009999)1.77951491
66Male pseudohermaphroditism (HP:0000037)1.75393930
67Coronal craniosynostosis (HP:0004440)1.74970502
68Methylmalonic acidemia (HP:0002912)1.74850913
69Soft skin (HP:0000977)1.73674738
70Triphalangeal thumb (HP:0001199)1.70967855
71Abnormality of renal resorption (HP:0011038)1.69419911
72Renal hypoplasia (HP:0000089)1.69373850
73Abnormality of dentin (HP:0010299)1.69172128
74Abnormal lung lobation (HP:0002101)1.68773627
75Partial duplication of thumb phalanx (HP:0009944)1.68420168
76Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68137135
77Aplasia/Hypoplasia of the hallux (HP:0008362)1.67959978
78Abnormality of urine glucose concentration (HP:0011016)1.67694918
79Glycosuria (HP:0003076)1.67694918
80Hemivertebrae (HP:0002937)1.66966532
81Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65981739
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65981739
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.65485159
84Adrenal hypoplasia (HP:0000835)1.64691580
85Respiratory failure (HP:0002878)1.64672279
86Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.64611905
87Occipital encephalocele (HP:0002085)1.63790268
88Meckel diverticulum (HP:0002245)1.62648664
89Abnormality of the anterior horn cell (HP:0006802)1.62479338
90Degeneration of anterior horn cells (HP:0002398)1.62479338
91Optic disc pallor (HP:0000543)1.62133128
92Congenital malformation of the right heart (HP:0011723)1.61704816
93Double outlet right ventricle (HP:0001719)1.61704816
94Hypoplastic left heart (HP:0004383)1.61412812
95Postaxial hand polydactyly (HP:0001162)1.60051722
96Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.58997586
97Preaxial hand polydactyly (HP:0001177)1.57530105
98Concave nail (HP:0001598)1.57124598
99Postaxial foot polydactyly (HP:0001830)1.55966704
100Hyperglycinemia (HP:0002154)1.55441507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.37746370
2VRK22.88374456
3WEE12.59022713
4TNIK2.44081245
5WNK32.34141976
6BMPR1B2.28573133
7EPHB22.15656013
8PBK1.97399815
9TSSK61.97183639
10PLK41.91873553
11PLK31.85871387
12TRIM281.85157336
13BUB11.85086800
14ERBB41.80440901
15STK161.77428517
16NUAK11.74050428
17SRPK11.73955614
18VRK11.71589783
19CASK1.68748776
20MKNK21.66931049
21ACVR1B1.59439188
22CDC71.59387630
23MKNK11.57145308
24MST41.56507953
25PLK21.47560812
26ERBB31.46416491
27TAF11.41349768
28MAP3K41.36604682
29MAP4K21.33614405
30NEK11.32901209
31TGFBR11.29775608
32MAPK151.25922592
33MAP3K121.25682604
34LIMK11.22844145
35ZAK1.22157026
36TIE11.21899840
37DYRK21.20709464
38BRSK21.20647451
39MYLK1.20444414
40BCR1.17482061
41STK38L1.17028858
42MAP2K71.16592794
43PDK21.15381837
44TTK1.13790051
45INSRR1.12494404
46GRK11.09793029
47DYRK31.02232001
48LATS11.01833803
49FGFR20.99709407
50STK390.98784591
51EIF2AK30.96059733
52PLK10.94172262
53CSNK1G10.91384073
54CSNK1G20.90005718
55STK30.87258493
56NME10.87024133
57PINK10.82300868
58EIF2AK10.81952974
59CSNK1G30.81726372
60ADRBK20.79159465
61PRKCG0.76899633
62PRKCE0.74125586
63LATS20.73091336
64EPHA40.73024885
65BCKDK0.71589925
66ADRBK10.71557761
67WNK40.71335472
68PAK30.71132103
69MARK10.69992460
70PASK0.67996234
71BRSK10.62045268
72FGFR10.60215416
73FLT30.59362545
74MAPK130.58264805
75CDK30.57547684
76AURKB0.57313755
77NEK20.56644461
78FRK0.50900228
79CSNK1A1L0.50299198
80OXSR10.49860095
81PAK40.48337680
82ROCK20.47341465
83CHEK20.47103638
84NTRK20.46977363
85ABL20.46715428
86CCNB10.46111246
87MINK10.46061375
88CSNK2A10.45359162
89MAPKAPK50.44905703
90NME20.44335360
91DDR20.43492382
92ILK0.43205131
93PAK20.41669119
94ROCK10.39128128
95CAMK2A0.39015428
96CSNK2A20.38856926
97RPS6KA40.38080865
98PRKD30.36165168
99EIF2AK20.35753548
100CDK80.34889696

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.73250192
2Protein export_Homo sapiens_hsa030603.60797213
3Ribosome_Homo sapiens_hsa030103.33705723
4Parkinsons disease_Homo sapiens_hsa050123.23671418
5Proteasome_Homo sapiens_hsa030503.15877374
6Huntingtons disease_Homo sapiens_hsa050162.36673601
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22873417
8Alzheimers disease_Homo sapiens_hsa050102.15903353
9RNA polymerase_Homo sapiens_hsa030202.03287660
10Mismatch repair_Homo sapiens_hsa034302.02794746
11Homologous recombination_Homo sapiens_hsa034401.83063594
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79998724
13Steroid biosynthesis_Homo sapiens_hsa001001.76933988
14Cardiac muscle contraction_Homo sapiens_hsa042601.72614416
15Basal transcription factors_Homo sapiens_hsa030221.69145602
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68515769
17Basal cell carcinoma_Homo sapiens_hsa052171.64610984
18Propanoate metabolism_Homo sapiens_hsa006401.63580705
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58508901
20Folate biosynthesis_Homo sapiens_hsa007901.49716211
21DNA replication_Homo sapiens_hsa030301.46382374
22Pyruvate metabolism_Homo sapiens_hsa006201.45429911
23Nucleotide excision repair_Homo sapiens_hsa034201.42536843
24Hedgehog signaling pathway_Homo sapiens_hsa043401.40097395
25Spliceosome_Homo sapiens_hsa030401.37837393
26Fanconi anemia pathway_Homo sapiens_hsa034601.36627016
27Fatty acid elongation_Homo sapiens_hsa000621.34474279
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28969808
29Glutathione metabolism_Homo sapiens_hsa004801.26028693
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23606546
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21208025
32RNA degradation_Homo sapiens_hsa030181.20567877
33Butanoate metabolism_Homo sapiens_hsa006501.19650863
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.15190373
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15049212
36RNA transport_Homo sapiens_hsa030131.10822681
37Sulfur metabolism_Homo sapiens_hsa009201.09069004
38TGF-beta signaling pathway_Homo sapiens_hsa043501.08887456
39Pyrimidine metabolism_Homo sapiens_hsa002401.07146484
40Hippo signaling pathway_Homo sapiens_hsa043901.04973641
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00274051
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.94816694
43Non-homologous end-joining_Homo sapiens_hsa034500.93447198
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89947781
45Purine metabolism_Homo sapiens_hsa002300.89498312
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86397871
47Base excision repair_Homo sapiens_hsa034100.86223841
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.86073126
49Wnt signaling pathway_Homo sapiens_hsa043100.84971887
50Selenocompound metabolism_Homo sapiens_hsa004500.84928017
51Cell cycle_Homo sapiens_hsa041100.84184281
52One carbon pool by folate_Homo sapiens_hsa006700.81439244
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79310667
54ECM-receptor interaction_Homo sapiens_hsa045120.77417765
55Phototransduction_Homo sapiens_hsa047440.77356316
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76706323
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76130715
58Collecting duct acid secretion_Homo sapiens_hsa049660.74767459
59Metabolic pathways_Homo sapiens_hsa011000.73844220
60Sulfur relay system_Homo sapiens_hsa041220.73697807
61Peroxisome_Homo sapiens_hsa041460.72885916
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71946439
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67388981
64Tryptophan metabolism_Homo sapiens_hsa003800.64832203
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64761699
66Protein digestion and absorption_Homo sapiens_hsa049740.63001008
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62552911
68Chemical carcinogenesis_Homo sapiens_hsa052040.61240300
69Nitrogen metabolism_Homo sapiens_hsa009100.59501338
70p53 signaling pathway_Homo sapiens_hsa041150.59270963
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58973437
72Nicotine addiction_Homo sapiens_hsa050330.58801494
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56773827
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56279003
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54501193
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53119177
77Fatty acid metabolism_Homo sapiens_hsa012120.50186310
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49468893
79beta-Alanine metabolism_Homo sapiens_hsa004100.49374583
80Oocyte meiosis_Homo sapiens_hsa041140.48856793
81N-Glycan biosynthesis_Homo sapiens_hsa005100.46849432
82Fatty acid degradation_Homo sapiens_hsa000710.46497473
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45112414
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44879397
85Vitamin B6 metabolism_Homo sapiens_hsa007500.44872400
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43683844
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.43097052
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42846426
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40833265
90Vibrio cholerae infection_Homo sapiens_hsa051100.39472475
91Arginine and proline metabolism_Homo sapiens_hsa003300.39420740
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38754564
93Retinol metabolism_Homo sapiens_hsa008300.38633385
94Carbon metabolism_Homo sapiens_hsa012000.38094836
95Melanogenesis_Homo sapiens_hsa049160.37332616
96Tight junction_Homo sapiens_hsa045300.34704761
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33192267
98Axon guidance_Homo sapiens_hsa043600.30828018
99Mineral absorption_Homo sapiens_hsa049780.30555065
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30002714

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