TCEANC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.65166736
2viral transcription (GO:0019083)5.96238189
3translational termination (GO:0006415)5.70177642
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.62307364
5DNA deamination (GO:0045006)5.41606618
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.21881471
7behavioral response to nicotine (GO:0035095)5.17948816
8ribosomal small subunit biogenesis (GO:0042274)5.14674590
9cotranslational protein targeting to membrane (GO:0006613)5.11645058
10protein targeting to ER (GO:0045047)5.07173869
11platelet dense granule organization (GO:0060155)4.99060625
12lymphoid progenitor cell differentiation (GO:0002320)4.90156481
13translational elongation (GO:0006414)4.88566958
14protein localization to endoplasmic reticulum (GO:0070972)4.84253679
15regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.82571488
16establishment of protein localization to endoplasmic reticulum (GO:0072599)4.82445963
17positive regulation of cellular amine metabolic process (GO:0033240)4.51035103
18negative regulation of erythrocyte differentiation (GO:0045647)4.49200328
19indole-containing compound catabolic process (GO:0042436)4.48041690
20indolalkylamine catabolic process (GO:0046218)4.48041690
21tryptophan catabolic process (GO:0006569)4.48041690
22indolalkylamine metabolic process (GO:0006586)4.44054754
23negative regulation of metanephros development (GO:0072217)4.42664703
24GDP-mannose metabolic process (GO:0019673)4.38768715
25respiratory chain complex IV assembly (GO:0008535)4.37411855
26kynurenine metabolic process (GO:0070189)4.35767832
27viral life cycle (GO:0019058)4.35415843
28peptidyl-threonine dephosphorylation (GO:0035970)4.27330622
29maturation of SSU-rRNA (GO:0030490)4.25257183
30nephron tubule formation (GO:0072079)4.24837168
31tryptophan metabolic process (GO:0006568)4.23638161
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.21987129
33cellular protein complex disassembly (GO:0043624)4.19919992
34telomere maintenance via semi-conservative replication (GO:0032201)4.19561930
35response to interferon-alpha (GO:0035455)4.19291096
36mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.18581284
37antigen processing and presentation via MHC class Ib (GO:0002475)4.15841388
38translational initiation (GO:0006413)3.93776952
39regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.89775928
40pattern specification involved in kidney development (GO:0061004)3.88170154
41response to interferon-beta (GO:0035456)3.87530551
42definitive hemopoiesis (GO:0060216)3.82408164
43response to pheromone (GO:0019236)3.80714948
44regulation of apoptotic process involved in morphogenesis (GO:1902337)3.75481408
45endosome to pigment granule transport (GO:0043485)3.72705602
46endosome to melanosome transport (GO:0035646)3.72705602
47cellular ketone body metabolic process (GO:0046950)3.70632526
48protein complex disassembly (GO:0043241)3.70306597
49neural tube formation (GO:0001841)3.66480923
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.63642667
51positive regulation of glycoprotein biosynthetic process (GO:0010560)3.62325786
52fucose catabolic process (GO:0019317)3.58894292
53L-fucose metabolic process (GO:0042354)3.58894292
54L-fucose catabolic process (GO:0042355)3.58894292
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.58856958
56mannosylation (GO:0097502)3.56978325
57negative regulation of mast cell activation (GO:0033004)3.52461178
58sulfation (GO:0051923)3.51498757
59indole-containing compound metabolic process (GO:0042430)3.49634250
60macromolecular complex disassembly (GO:0032984)3.48768542
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47631064
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.47631064
63detection of light stimulus involved in sensory perception (GO:0050962)3.42337137
64detection of light stimulus involved in visual perception (GO:0050908)3.42337137
65rRNA catabolic process (GO:0016075)3.41531627
66telomere maintenance via recombination (GO:0000722)3.38501637
67positive regulation of B cell differentiation (GO:0045579)3.37816509
68urogenital system development (GO:0001655)3.37089755
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36740024
70mature B cell differentiation involved in immune response (GO:0002313)3.35506824
71DNA strand elongation involved in DNA replication (GO:0006271)3.35258927
72protein polyglutamylation (GO:0018095)3.35247694
73primary amino compound metabolic process (GO:1901160)3.35178821
74cytochrome complex assembly (GO:0017004)3.34980376
75mesonephros development (GO:0001823)3.33067059
76generation of neurons (GO:0048699)3.32433565
77protein targeting to membrane (GO:0006612)3.31971738
78positive regulation of hormone metabolic process (GO:0032352)3.30575313
79ketone body metabolic process (GO:1902224)3.30239998
80interkinetic nuclear migration (GO:0022027)3.28946497
81N-acetylneuraminate metabolic process (GO:0006054)3.28711198
82facial nerve structural organization (GO:0021612)3.23397242
83GPI anchor biosynthetic process (GO:0006506)3.21862110
84DNA strand elongation (GO:0022616)3.21392495
85positive regulation of T cell mediated cytotoxicity (GO:0001916)3.18554495
86nuclear-transcribed mRNA catabolic process (GO:0000956)3.16027661
87mast cell activation (GO:0045576)3.15723860
88DNA replication initiation (GO:0006270)3.15461267
89negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.14521429
90regulation of type B pancreatic cell apoptotic process (GO:2000674)3.14510340
91positive regulation of protein export from nucleus (GO:0046827)3.14276907
92serotonin metabolic process (GO:0042428)3.13974373
93pseudouridine synthesis (GO:0001522)3.11752238
94secretory granule organization (GO:0033363)3.08897591
95NAD biosynthetic process (GO:0009435)3.07060090
96megakaryocyte development (GO:0035855)3.06646147
97translation (GO:0006412)3.05895649
98defense response to protozoan (GO:0042832)3.05227189
99positive regulation of metanephros development (GO:0072216)3.04525078
100mRNA catabolic process (GO:0006402)3.02454948
101ribosomal large subunit biogenesis (GO:0042273)3.02240087
102kidney morphogenesis (GO:0060993)2.99442793
103axoneme assembly (GO:0035082)2.98802845
104regulation of T cell mediated cytotoxicity (GO:0001914)2.96370406
105negative regulation of telomere maintenance (GO:0032205)2.95932614
106diacylglycerol metabolic process (GO:0046339)2.93429747
107protein K11-linked deubiquitination (GO:0035871)2.93386100
108mast cell activation involved in immune response (GO:0002279)2.91934136
109mast cell degranulation (GO:0043303)2.91934136
110GMP metabolic process (GO:0046037)2.91889533
111positive regulation of defense response to virus by host (GO:0002230)2.91016204
112C-terminal protein lipidation (GO:0006501)2.90725586
113lymph node development (GO:0048535)2.89812804
114thyroid gland development (GO:0030878)2.87751833
115cilium or flagellum-dependent cell motility (GO:0001539)2.86889143
116RNA catabolic process (GO:0006401)2.86722129
117cellular response to thyroid hormone stimulus (GO:0097067)2.84071355
118reciprocal meiotic recombination (GO:0007131)2.84031693
119reciprocal DNA recombination (GO:0035825)2.84031693
120piRNA metabolic process (GO:0034587)2.83039953
121recombinational repair (GO:0000725)2.81776946
122regulation of hippo signaling (GO:0035330)2.81142826
123mitotic recombination (GO:0006312)2.80919915
124regulation of nuclear cell cycle DNA replication (GO:0033262)2.80710416
125negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.80350543
126response to protozoan (GO:0001562)2.80338847
127double-strand break repair via homologous recombination (GO:0000724)2.80275013
128replication fork processing (GO:0031297)2.79051602
129phospholipid scrambling (GO:0017121)2.78647561
130antigen processing and presentation of endogenous antigen (GO:0019883)2.78436945
131DNA demethylation (GO:0080111)2.78384097
132oxidative demethylation (GO:0070989)2.78284814
133mature B cell differentiation (GO:0002335)2.76847340
134ribonucleoprotein complex biogenesis (GO:0022613)2.76343810
135positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76129983
136regulation of rhodopsin mediated signaling pathway (GO:0022400)2.75801447
137gamma-aminobutyric acid transport (GO:0015812)2.75565248
138reflex (GO:0060004)2.75497312
139negative regulation of translation, ncRNA-mediated (GO:0040033)2.75251643
140regulation of translation, ncRNA-mediated (GO:0045974)2.75251643
141negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.75251643
142epithelial cilium movement (GO:0003351)2.74203928
143activated T cell proliferation (GO:0050798)2.73620153
144regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.73322293
145RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73308196
146fucosylation (GO:0036065)2.72324657
147mitochondrial respiratory chain complex I assembly (GO:0032981)2.71521263
148regulation of B cell differentiation (GO:0045577)2.70888482
149telomere maintenance via telomere lengthening (GO:0010833)2.70531235
150dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.70429823
151mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70371135
152NADH dehydrogenase complex assembly (GO:0010257)2.70371135
153rhodopsin mediated signaling pathway (GO:0016056)2.68922899
154multicellular organism reproduction (GO:0032504)2.68616162
155regulation of memory T cell differentiation (GO:0043380)2.67932192
156neuronal action potential (GO:0019228)2.66689742
157water-soluble vitamin biosynthetic process (GO:0042364)2.64161662
158regulation of gene silencing by RNA (GO:0060966)2.63850956
159regulation of posttranscriptional gene silencing (GO:0060147)2.63850956
160regulation of gene silencing by miRNA (GO:0060964)2.63850956
161cellular response to exogenous dsRNA (GO:0071360)2.59776323
162cellular response to ATP (GO:0071318)2.59262244
163cAMP catabolic process (GO:0006198)2.57606838
164amine catabolic process (GO:0009310)2.57301552
165cellular biogenic amine catabolic process (GO:0042402)2.57301552
166centriole replication (GO:0007099)2.54947772
167protein import into peroxisome matrix (GO:0016558)2.54773178
168cytidine metabolic process (GO:0046087)2.53736889
169cytidine catabolic process (GO:0006216)2.53736889
170cytidine deamination (GO:0009972)2.53736889
171preassembly of GPI anchor in ER membrane (GO:0016254)2.53710225
172auditory receptor cell stereocilium organization (GO:0060088)2.53019261
173DNA methylation involved in gamete generation (GO:0043046)2.50040977
174cornea development in camera-type eye (GO:0061303)2.49177995
175protein complex biogenesis (GO:0070271)2.48074268
176spinal cord motor neuron differentiation (GO:0021522)2.47447485
177cilium movement (GO:0003341)2.46639977
178cilium organization (GO:0044782)2.45094720
179negative regulation of DNA-dependent DNA replication (GO:2000104)2.44362919
180photoreceptor cell maintenance (GO:0045494)2.42169202
181signal peptide processing (GO:0006465)2.41324282
182benzene-containing compound metabolic process (GO:0042537)2.41306937
183nonmotile primary cilium assembly (GO:0035058)2.40738878
184embryonic epithelial tube formation (GO:0001838)2.39851692
185mitochondrial respiratory chain complex assembly (GO:0033108)2.39378775
186negative regulation of systemic arterial blood pressure (GO:0003085)2.39369132
187somite development (GO:0061053)2.39200413
188positive regulation of oligodendrocyte differentiation (GO:0048714)2.39163446
189behavioral response to ethanol (GO:0048149)2.37541743
190somatic diversification of immune receptors via somatic mutation (GO:0002566)2.37120642
191somatic hypermutation of immunoglobulin genes (GO:0016446)2.37120642
192regulation of action potential (GO:0098900)2.36050114
193protein K63-linked deubiquitination (GO:0070536)2.36031479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.35928321
2ZNF274_21170338_ChIP-Seq_K562_Hela3.98169544
3SCL_19346495_ChIP-Seq_HPC-7_Human3.77953302
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51177596
5E2F7_22180533_ChIP-Seq_HELA_Human3.39635990
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.38804963
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.27892135
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.22824557
9VDR_22108803_ChIP-Seq_LS180_Human3.17214696
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.11235942
11EZH2_22144423_ChIP-Seq_EOC_Human3.01939001
12FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.98118544
13TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.96575062
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94879950
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.92664572
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92501280
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.91922407
18GATA1_22025678_ChIP-Seq_K562_Human2.79822533
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.77599338
20GBX2_23144817_ChIP-Seq_PC3_Human2.77001638
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.70644764
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70515644
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.66199598
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55961639
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.53087102
26ERG_20887958_ChIP-Seq_HPC-7_Mouse2.49075001
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48396932
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.45821201
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44667959
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41130581
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36223571
32IGF1R_20145208_ChIP-Seq_DFB_Human2.34763951
33ETS1_20019798_ChIP-Seq_JURKAT_Human2.31762525
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29670898
35FLI1_27457419_Chip-Seq_LIVER_Mouse2.27482317
36POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23802706
37VDR_23849224_ChIP-Seq_CD4+_Human2.20228387
38MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19678283
39EWS_26573619_Chip-Seq_HEK293_Human2.19273378
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17213363
41CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16775675
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.15355218
43HOXB4_20404135_ChIP-ChIP_EML_Mouse2.14391265
44FUS_26573619_Chip-Seq_HEK293_Human2.06155650
45ER_23166858_ChIP-Seq_MCF-7_Human2.05218025
46* SPI1_23547873_ChIP-Seq_NB4_Human2.03383060
47CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02253514
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.99992892
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.99958647
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.94969534
51TAF15_26573619_Chip-Seq_HEK293_Human1.93626552
52VDR_21846776_ChIP-Seq_THP-1_Human1.91924390
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.90064013
54FOXP3_21729870_ChIP-Seq_TREG_Human1.88191421
55P300_19829295_ChIP-Seq_ESCs_Human1.88068739
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86945599
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85977785
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84930399
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83059568
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82324630
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82279805
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80421814
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76978736
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.76912589
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74966987
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72521637
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.72504691
68XRN2_22483619_ChIP-Seq_HELA_Human1.69612917
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68049472
70STAT3_23295773_ChIP-Seq_U87_Human1.68003773
71MYC_22102868_ChIP-Seq_BL_Human1.67253086
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65889230
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65636820
74CIITA_25753668_ChIP-Seq_RAJI_Human1.65178454
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64447667
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64242781
77VDR_24763502_ChIP-Seq_THP-1_Human1.62440342
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60337534
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59239210
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57412175
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56493846
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.53658826
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51577382
84IRF1_19129219_ChIP-ChIP_H3396_Human1.50970947
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50804947
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50804947
87AR_21572438_ChIP-Seq_LNCaP_Human1.50248694
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49152154
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49009384
90CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48200451
91TCF4_23295773_ChIP-Seq_U87_Human1.48091809
92TP53_22573176_ChIP-Seq_HFKS_Human1.47233462
93BCAT_22108803_ChIP-Seq_LS180_Human1.47131139
94MYB_26560356_Chip-Seq_TH2_Human1.47128897
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46080901
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44213119
97CBP_20019798_ChIP-Seq_JUKART_Human1.44213119
98DCP1A_22483619_ChIP-Seq_HELA_Human1.43514698
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43223005
100GABP_19822575_ChIP-Seq_HepG2_Human1.39875875
101SMAD4_21799915_ChIP-Seq_A2780_Human1.39457621
102TTF2_22483619_ChIP-Seq_HELA_Human1.39197997
103AR_25329375_ChIP-Seq_VCAP_Human1.38309087
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36935789
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33836839
106NANOG_19829295_ChIP-Seq_ESCs_Human1.32519422
107SOX2_19829295_ChIP-Seq_ESCs_Human1.32519422
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.32406942
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32210800
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31739831
111FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31616944
112FOXA1_25329375_ChIP-Seq_VCAP_Human1.31616944
113ELK1_19687146_ChIP-ChIP_HELA_Human1.31416623
114IRF8_21731497_ChIP-ChIP_J774_Mouse1.31204235
115GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30365366
116MYB_26560356_Chip-Seq_TH1_Human1.30322404
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29685815
118MAF_26560356_Chip-Seq_TH1_Human1.29029330
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.27405148
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.26609854
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26589400
122CBX2_27304074_Chip-Seq_ESCs_Mouse1.25436797
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25344939
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.24917081
125NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24741237
126YY1_21170310_ChIP-Seq_MESCs_Mouse1.24271120
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22712666
128TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22595129
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22078193
130BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22023968
131E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21929516
132FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21789949
133ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21381345
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21326898
135NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20245924
136FLI1_21867929_ChIP-Seq_TH2_Mouse1.19954477
137TCF4_22108803_ChIP-Seq_LS180_Human1.19537756
138SMAD3_21741376_ChIP-Seq_EPCs_Human1.18649649
139GATA3_21878914_ChIP-Seq_MCF-7_Human1.16504910
140REST_21632747_ChIP-Seq_MESCs_Mouse1.16297416
141RUNX2_22187159_ChIP-Seq_PCA_Human1.15468235
142PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15306844
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14315281
144SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14192976
145KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13622996
146GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13573032
147SMAD4_21741376_ChIP-Seq_EPCs_Human1.13386672
148GATA1_19941827_ChIP-Seq_MEL_Mouse1.12478529
149AR_20517297_ChIP-Seq_VCAP_Human1.12043118
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11730089
151NCOR_22424771_ChIP-Seq_293T_Human1.11142454
152ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10774676
153ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10142650
154UTX_26944678_Chip-Seq_JUKART_Human1.09531956
155CRX_20693478_ChIP-Seq_RETINA_Mouse1.08932585
156TP53_16413492_ChIP-PET_HCT116_Human1.08528689
157GATA3_26560356_Chip-Seq_TH2_Human1.08070112
158HOXB7_26014856_ChIP-Seq_BT474_Human1.04849938
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04214615
160RNF2_27304074_Chip-Seq_NSC_Mouse1.04055944
161TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03154602
162NANOG_18555785_Chip-Seq_ESCs_Mouse1.00919596
163EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00722901
164SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00278615
165P53_22387025_ChIP-Seq_ESCs_Mouse0.99508383
166FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99271188
167OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98930445
168AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98360582
169CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98185718
170MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98148367
171FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97721077
172BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97300048
173PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97094585
174EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96907453
175IRF8_27001747_Chip-Seq_BMDM_Mouse0.96498569
176BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96447267
177DROSHA_22980978_ChIP-Seq_HELA_Human0.96416238
178TP63_19390658_ChIP-ChIP_HaCaT_Human0.96273051
179E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95858995
180CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95834402
181POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95088218
182PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94853808
183PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94354171
184CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92011763
185MYC_18940864_ChIP-ChIP_HL60_Human0.89681953
186TCF7_22412390_ChIP-Seq_EML_Mouse0.89358983
187MAF_26560356_Chip-Seq_TH2_Human0.89090613
188SPI1_23127762_ChIP-Seq_K562_Human0.88474197
189TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86496828
190MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86275775
191RUNX_20019798_ChIP-Seq_JUKART_Human0.85683537
192NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85427564
193FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.85257408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.41505415
2MP0002396_abnormal_hematopoietic_system4.02961952
3MP0005174_abnormal_tail_pigmentation3.80588962
4MP0000569_abnormal_digit_pigmentation3.69541607
5MP0003195_calcinosis3.32476201
6MP0001835_abnormal_antigen_presentation3.05019190
7MP0005075_abnormal_melanosome_morpholog3.04365905
8MP0004147_increased_porphyrin_level2.84152551
9MP0000685_abnormal_immune_system2.79834008
10MP0009785_altered_susceptibility_to2.79622322
11MP0001188_hyperpigmentation2.76199541
12MP0000490_abnormal_crypts_of2.74660024
13MP0005409_darkened_coat_color2.72326474
14MP0002102_abnormal_ear_morphology2.68172854
15MP0005671_abnormal_response_to2.66867888
16MP0003868_abnormal_feces_composition2.60210857
17MP0008877_abnormal_DNA_methylation2.55611801
18MP0005397_hematopoietic_system_phenotyp2.50205191
19MP0001545_abnormal_hematopoietic_system2.50205191
20MP0002095_abnormal_skin_pigmentation2.30978664
21MP0000015_abnormal_ear_pigmentation2.26483082
22MP0006292_abnormal_olfactory_placode2.23777167
23MP0005551_abnormal_eye_electrophysiolog2.21858789
24MP0002653_abnormal_ependyma_morphology2.21477354
25MP0002837_dystrophic_cardiac_calcinosis2.10918141
26MP0000465_gastrointestinal_hemorrhage2.10431563
27MP0005025_abnormal_response_to2.08611594
28MP0003724_increased_susceptibility_to2.08069634
29MP0003763_abnormal_thymus_physiology2.04985147
30MP0004808_abnormal_hematopoietic_stem2.01738863
31MP0000681_abnormal_thyroid_gland2.00558626
32MP0003879_abnormal_hair_cell1.97752829
33MP0004142_abnormal_muscle_tone1.97319769
34MP0001986_abnormal_taste_sensitivity1.96721350
35MP0002398_abnormal_bone_marrow1.93069220
36MP0004043_abnormal_pH_regulation1.92242718
37MP0002148_abnormal_hypersensitivity_rea1.86480339
38MP0001968_abnormal_touch/_nociception1.86364789
39MP0004885_abnormal_endolymph1.80963602
40MP0001485_abnormal_pinna_reflex1.80082471
41MP0001800_abnormal_humoral_immune1.79477971
42MP0004145_abnormal_muscle_electrophysio1.79210821
43MP0008872_abnormal_physiological_respon1.78096822
44MP0005464_abnormal_platelet_physiology1.76889015
45MP0003656_abnormal_erythrocyte_physiolo1.75448009
46MP0003693_abnormal_embryo_hatching1.73708457
47MP0005000_abnormal_immune_tolerance1.70927716
48MP0000689_abnormal_spleen_morphology1.69203099
49MP0002723_abnormal_immune_serum1.68558514
50MP0002420_abnormal_adaptive_immunity1.68551267
51MP0009745_abnormal_behavioral_response1.68301548
52MP0009046_muscle_twitch1.67967213
53MP0010155_abnormal_intestine_physiology1.67239534
54MP0001819_abnormal_immune_cell1.65918966
55MP0000427_abnormal_hair_cycle1.64517538
56MP0001501_abnormal_sleep_pattern1.63306023
57MP0003646_muscle_fatigue1.63304433
58MP0001873_stomach_inflammation1.62481590
59MP0008007_abnormal_cellular_replicative1.61371143
60MP0003436_decreased_susceptibility_to1.60571705
61MP0002722_abnormal_immune_system1.59414127
62MP0002452_abnormal_antigen_presenting1.59214914
63MP0009333_abnormal_splenocyte_physiolog1.59019504
64MP0005253_abnormal_eye_physiology1.58949792
65MP0000716_abnormal_immune_system1.58243773
66MP0005645_abnormal_hypothalamus_physiol1.56909083
67MP0003866_abnormal_defecation1.56237531
68MP0000372_irregular_coat_pigmentation1.53873255
69MP0002166_altered_tumor_susceptibility1.52659874
70MP0008875_abnormal_xenobiotic_pharmacok1.52379294
71MP0002735_abnormal_chemical_nociception1.51778518
72MP0001853_heart_inflammation1.51197984
73MP0002736_abnormal_nociception_after1.50376934
74MP0004742_abnormal_vestibular_system1.50051321
75MP0002429_abnormal_blood_cell1.47902287
76MP0005646_abnormal_pituitary_gland1.47268795
77MP0002419_abnormal_innate_immunity1.43435947
78MP0006072_abnormal_retinal_apoptosis1.42294253
79MP0002928_abnormal_bile_duct1.40574178
80MP0002138_abnormal_hepatobiliary_system1.35516278
81MP0005389_reproductive_system_phenotype1.34963961
82MP0006054_spinal_hemorrhage1.34956558
83MP0002160_abnormal_reproductive_system1.32387661
84MP0006036_abnormal_mitochondrial_physio1.31886990
85MP0001486_abnormal_startle_reflex1.27942412
86MP0002272_abnormal_nervous_system1.26748586
87MP0008058_abnormal_DNA_repair1.25083606
88MP0004381_abnormal_hair_follicle1.24803504
89MP0000383_abnormal_hair_follicle1.23545962
90MP0002277_abnormal_respiratory_mucosa1.22993736
91MP0001790_abnormal_immune_system1.21351671
92MP0005387_immune_system_phenotype1.21351671
93MP0006276_abnormal_autonomic_nervous1.18327143
94MP0002006_tumorigenesis1.16819332
95MP0005377_hearing/vestibular/ear_phenot1.15890166
96MP0003878_abnormal_ear_physiology1.15890166
97MP0002163_abnormal_gland_morphology1.15349768
98MP0003787_abnormal_imprinting1.15037359
99MP0004133_heterotaxia1.14454649
100MP0002132_abnormal_respiratory_system1.11267973
101MP0001845_abnormal_inflammatory_respons1.11207969
102MP0002064_seizures1.10062920
103MP0002938_white_spotting1.09600211
104MP0001919_abnormal_reproductive_system1.08331739
105MP0000703_abnormal_thymus_morphology1.08047267
106MP0008469_abnormal_protein_level1.07427524
107MP0004130_abnormal_muscle_cell1.07358328
108MP0002405_respiratory_system_inflammati1.04541819
109MP0002733_abnormal_thermal_nociception1.04372819
110MP0002572_abnormal_emotion/affect_behav1.03757708
111MP0003806_abnormal_nucleotide_metabolis1.03360196
112MP0002019_abnormal_tumor_incidence1.03090277
113MP0005167_abnormal_blood-brain_barrier1.00813628
114MP0002067_abnormal_sensory_capabilities1.00048227
115MP0005171_absent_coat_pigmentation0.99436645
116MP0010094_abnormal_chromosome_stability0.99267597
117MP0003718_maternal_effect0.97954648
118MP0001970_abnormal_pain_threshold0.96843908
119MP0008961_abnormal_basal_metabolism0.96079650
120MP0003136_yellow_coat_color0.96008191
121MP0005379_endocrine/exocrine_gland_phen0.95520002
122MP0002177_abnormal_outer_ear0.92712067
123MP0003959_abnormal_lean_body0.92641217
124MP0002557_abnormal_social/conspecific_i0.92626310
125MP0004924_abnormal_behavior0.91698449
126MP0005386_behavior/neurological_phenoty0.91698449
127MP0002876_abnormal_thyroid_physiology0.91635394
128MP0001663_abnormal_digestive_system0.87878998
129MP0005410_abnormal_fertilization0.87757453
130MP0008995_early_reproductive_senescence0.86613690
131MP0005195_abnormal_posterior_eye0.86255380
132MP0003890_abnormal_embryonic-extraembry0.84893946
133MP0000477_abnormal_intestine_morphology0.84752100
134MP0000371_diluted_coat_color0.84373983
135MP0002234_abnormal_pharynx_morphology0.83710254
136MP0005310_abnormal_salivary_gland0.83661007
137MP0003252_abnormal_bile_duct0.82869470
138MP0000631_abnormal_neuroendocrine_gland0.82780162
139MP0002638_abnormal_pupillary_reflex0.82746878
140MP0000230_abnormal_systemic_arterial0.81446608
141MP0005085_abnormal_gallbladder_physiolo0.81057697
142MP0003011_delayed_dark_adaptation0.79699087
143MP0003186_abnormal_redox_activity0.79404394
144MP0001929_abnormal_gametogenesis0.76846947
145MP0003698_abnormal_male_reproductive0.76538619
146MP0005584_abnormal_enzyme/coenzyme_acti0.75607658
147MP0002075_abnormal_coat/hair_pigmentati0.75594900
148MP0000343_altered_response_to0.75144168
149MP0001324_abnormal_eye_pigmentation0.74550317
150MP0002063_abnormal_learning/memory/cond0.74478374
151MP0005266_abnormal_metabolism0.74327350
152MP0001348_abnormal_lacrimal_gland0.74261104
153MP0003786_premature_aging0.74214344
154MP0000049_abnormal_middle_ear0.74163739
155MP0008569_lethality_at_weaning0.73905033
156MP0010386_abnormal_urinary_bladder0.73500489
157MP0004215_abnormal_myocardial_fiber0.72880776
158MP0003077_abnormal_cell_cycle0.72857098
159MP0000026_abnormal_inner_ear0.72313744
160MP0004957_abnormal_blastocyst_morpholog0.71996655
161MP0008057_abnormal_DNA_replication0.69339754
162MP0003828_pulmonary_edema0.64489100
163MP0000313_abnormal_cell_death0.64058444
164MP0003938_abnormal_ear_development0.62517740
165MP0002933_joint_inflammation0.60726068
166MP0000470_abnormal_stomach_morphology0.60507101
167MP0003943_abnormal_hepatobiliary_system0.60001828
168MP0009764_decreased_sensitivity_to0.59566749
169MP0003567_abnormal_fetal_cardiomyocyte0.59530035
170MP0005636_abnormal_mineral_homeostasis0.59177252
171MP0002693_abnormal_pancreas_physiology0.57607625
172MP0005084_abnormal_gallbladder_morpholo0.56594004

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)7.00389410
2Type I transferrin isoform profile (HP:0003642)6.50678972
3Hypothermia (HP:0002045)6.33529801
4Abnormality of cells of the erythroid lineage (HP:0012130)5.72838320
5Thyroid-stimulating hormone excess (HP:0002925)5.66607457
6Abnormal number of erythroid precursors (HP:0012131)5.63596047
7Pancreatic cysts (HP:0001737)4.84010592
8Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.67970509
9Abnormal protein N-linked glycosylation (HP:0012347)4.67970509
10Abnormal protein glycosylation (HP:0012346)4.67970509
11Abnormal glycosylation (HP:0012345)4.67970509
12Pancreatic fibrosis (HP:0100732)4.13771880
13Abnormality of the heme biosynthetic pathway (HP:0010472)4.06082014
14Molar tooth sign on MRI (HP:0002419)4.04203743
15Abnormality of midbrain morphology (HP:0002418)4.04203743
16Congenital stationary night blindness (HP:0007642)3.97132179
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.95433233
18Aplastic anemia (HP:0001915)3.94398709
19Thrombocytosis (HP:0001894)3.84555109
20Reticulocytopenia (HP:0001896)3.77638874
21Nephronophthisis (HP:0000090)3.61404803
22Elevated erythrocyte sedimentation rate (HP:0003565)3.60915280
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.49865522
24IgM deficiency (HP:0002850)3.42623624
25Abnormality of the renal cortex (HP:0011035)3.40490677
26Hepatocellular necrosis (HP:0001404)3.40285737
27Severe visual impairment (HP:0001141)3.40106820
28Chronic otitis media (HP:0000389)3.29410104
29Petechiae (HP:0000967)3.29397224
30Type 2 muscle fiber atrophy (HP:0003554)3.27912632
31Muscle fiber atrophy (HP:0100295)3.27832172
32Abnormality of the renal medulla (HP:0100957)3.25719977
33Pallor (HP:0000980)3.25297170
34Genetic anticipation (HP:0003743)3.24207812
35Increased hepatocellular lipid droplets (HP:0006565)3.20491536
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.15723481
37Prolonged partial thromboplastin time (HP:0003645)3.12714793
38Chronic hepatic failure (HP:0100626)3.11422958
39Abolished electroretinogram (ERG) (HP:0000550)3.07655632
40Inability to walk (HP:0002540)3.06950015
41Macrocytic anemia (HP:0001972)2.98802084
42Nonprogressive disorder (HP:0003680)2.97511220
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.96157726
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.96157726
45Myositis (HP:0100614)2.92739909
46Prolonged bleeding time (HP:0003010)2.92453900
47Hyperventilation (HP:0002883)2.91438603
48Exertional dyspnea (HP:0002875)2.88547627
49Gaze-evoked nystagmus (HP:0000640)2.86553350
50Hepatic necrosis (HP:0002605)2.86466141
51Lipid accumulation in hepatocytes (HP:0006561)2.85840482
52Renal Fanconi syndrome (HP:0001994)2.85414337
53Cystic liver disease (HP:0006706)2.81679691
54Increased intramyocellular lipid droplets (HP:0012240)2.76854687
553-Methylglutaconic aciduria (HP:0003535)2.70831477
56Progressive cerebellar ataxia (HP:0002073)2.68838609
57Ankle contracture (HP:0006466)2.67477785
58Progressive inability to walk (HP:0002505)2.66641740
59Type II lissencephaly (HP:0007260)2.64892903
60Birth length less than 3rd percentile (HP:0003561)2.64682604
61Abnormality of the pons (HP:0007361)2.64207997
62Cortical visual impairment (HP:0100704)2.64159126
63Furrowed tongue (HP:0000221)2.58389384
64Hypoplasia of the pons (HP:0012110)2.53707919
65Dynein arm defect of respiratory motile cilia (HP:0012255)2.52521666
66Absent/shortened dynein arms (HP:0200106)2.52521666
67Microcytic anemia (HP:0001935)2.51071686
68Tubular atrophy (HP:0000092)2.50268140
69Abnormal rod and cone electroretinograms (HP:0008323)2.49982733
70Acute lymphatic leukemia (HP:0006721)2.49379124
71Decreased central vision (HP:0007663)2.47417546
72Panhypogammaglobulinemia (HP:0003139)2.47046595
73Increased muscle lipid content (HP:0009058)2.46321153
74Large for gestational age (HP:0001520)2.45730075
75Epistaxis (HP:0000421)2.44673056
76Flat occiput (HP:0005469)2.43948388
77Keratoconus (HP:0000563)2.42085580
78Increased corneal curvature (HP:0100692)2.42085580
79Renal cortical cysts (HP:0000803)2.41838530
80Microvesicular hepatic steatosis (HP:0001414)2.40358873
81Concave nail (HP:0001598)2.38382083
82Lower limb hyperreflexia (HP:0002395)2.38320844
83Medial flaring of the eyebrow (HP:0010747)2.37916372
84Sclerocornea (HP:0000647)2.36352623
85Respiratory difficulties (HP:0002880)2.35694948
86Abnormal drinking behavior (HP:0030082)2.35421695
87Polydipsia (HP:0001959)2.35421695
88Clumsiness (HP:0002312)2.33957638
89Stomach cancer (HP:0012126)2.30681413
90Abnormal biliary tract physiology (HP:0012439)2.30615663
91Bile duct proliferation (HP:0001408)2.30615663
92Congenital, generalized hypertrichosis (HP:0004540)2.30020606
93Abnormality of T cell physiology (HP:0011840)2.29598887
94Recurrent bronchitis (HP:0002837)2.28844319
95Mitochondrial inheritance (HP:0001427)2.28677201
96Impaired platelet aggregation (HP:0003540)2.25008136
97Abnormal platelet function (HP:0011869)2.25008136
98Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23935211
99Aplasia/Hypoplasia of the uvula (HP:0010293)2.21102430
100Anencephaly (HP:0002323)2.20256560
101Decreased circulating renin level (HP:0003351)2.20081683
102Hypoproteinemia (HP:0003075)2.19517857
103Protruding tongue (HP:0010808)2.19388661
104Pancytopenia (HP:0001876)2.18080639
105Congenital hepatic fibrosis (HP:0002612)2.17961663
106Attenuation of retinal blood vessels (HP:0007843)2.17794183
107Patellar aplasia (HP:0006443)2.17027930
108Constricted visual fields (HP:0001133)2.15783231
109Acute myeloid leukemia (HP:0004808)2.14215824
110Bony spicule pigmentary retinopathy (HP:0007737)2.10714319
111Hyperbilirubinemia (HP:0002904)2.10503454
112Aplasia/Hypoplasia of the tongue (HP:0010295)2.10230584
113B lymphocytopenia (HP:0010976)2.10085127
114Abnormality of B cell number (HP:0010975)2.10085127
115Recurrent abscess formation (HP:0002722)2.09989186
116Aplasia/Hypoplasia of the patella (HP:0006498)2.09981184
117Agammaglobulinemia (HP:0004432)2.08352469
118Abnormality of the renal collecting system (HP:0004742)2.07968471
119Chorioretinal atrophy (HP:0000533)2.06504965
120Erythema (HP:0010783)2.05960396
121Abnormality of the nasal mucosa (HP:0000433)2.05713828
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05401424
123Increased serum lactate (HP:0002151)2.04780066
124Aplasia/Hypoplasia of the tibia (HP:0005772)2.03247984
125Progressive muscle weakness (HP:0003323)2.03215697
126Gastrointestinal stroma tumor (HP:0100723)2.01410329
127Abnormal respiratory motile cilium morphology (HP:0005938)2.01252574
128Abnormal respiratory epithelium morphology (HP:0012253)2.01252574
129Male pseudohermaphroditism (HP:0000037)2.00065110
130Cerebellar dysplasia (HP:0007033)1.98431160
131Abnormality of magnesium homeostasis (HP:0004921)1.98384507
132Increased CSF lactate (HP:0002490)1.98357180
133Meningitis (HP:0001287)1.97383612
134Congenital sensorineural hearing impairment (HP:0008527)1.96990919
135Duplicated collecting system (HP:0000081)1.96457733
136Thoracic kyphosis (HP:0002942)1.95809237
137Hyperpituitarism (HP:0010514)1.95669191
138Febrile seizures (HP:0002373)1.95492860
139Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95241104
140Pendular nystagmus (HP:0012043)1.94642449
141Stomatitis (HP:0010280)1.94294478
142Abnormality of macular pigmentation (HP:0008002)1.94263337
143Abnormal ciliary motility (HP:0012262)1.93904248
144Aplasia/Hypoplasia of the spleen (HP:0010451)1.93363751
145IgG deficiency (HP:0004315)1.91073343
146Amaurosis fugax (HP:0100576)1.90590861
147Fair hair (HP:0002286)1.86909642
148Polyuria (HP:0000103)1.86151949
149Asplenia (HP:0001746)1.85156408
150Widely spaced teeth (HP:0000687)1.84791517
151Clubbing of toes (HP:0100760)1.83986365
152Recurrent bacterial skin infections (HP:0005406)1.83032999
153Lissencephaly (HP:0001339)1.82980895
154Nasal polyposis (HP:0100582)1.81367264
155Increased neuronal autofluorescent lipopigment (HP:0002074)1.80273427
156Gait imbalance (HP:0002141)1.80198624
157Recurrent viral infections (HP:0004429)1.79699674
158Abnormality of the ileum (HP:0001549)1.78019104
159Abnormality of the prostate (HP:0008775)1.76986455
160Purpura (HP:0000979)1.76600184
161Abnormal delayed hypersensitivity skin test (HP:0002963)1.76323383
162Congenital primary aphakia (HP:0007707)1.75745122
163Broad-based gait (HP:0002136)1.74708587
164Ragged-red muscle fibers (HP:0003200)1.74252427
165Abnormality of the columella (HP:0009929)1.72993800
166Poikiloderma (HP:0001029)1.72720678
167Lactic acidosis (HP:0003128)1.72477037
168Small hand (HP:0200055)1.72231386
169Postaxial foot polydactyly (HP:0001830)1.71828271
170Meckel diverticulum (HP:0002245)1.71711699
171Oral leukoplakia (HP:0002745)1.70918669
172Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70521745
173Abnormality of alanine metabolism (HP:0010916)1.70521745
174Hyperalaninemia (HP:0003348)1.70521745
175Partial agenesis of the corpus callosum (HP:0001338)1.69764574
176Migraine (HP:0002076)1.69524856
177Abnormality of chromosome stability (HP:0003220)1.69224347
178Broad face (HP:0000283)1.69025654
179True hermaphroditism (HP:0010459)1.68418578
180Sloping forehead (HP:0000340)1.67975317
181Absent speech (HP:0001344)1.67855961
182Oligohydramnios (HP:0001562)1.65564011
183Lymphoma (HP:0002665)1.65266827
184Hemiparesis (HP:0001269)1.64314600
185Albinism (HP:0001022)1.64248778
186Abnormality of DNA repair (HP:0003254)1.63954096
187Genital tract atresia (HP:0001827)1.63751757
188Gastrointestinal inflammation (HP:0004386)1.63389417
189Severe muscular hypotonia (HP:0006829)1.63384649
190Astigmatism (HP:0000483)1.62810393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK9.96543308
2FRK6.45956849
3NLK3.77408516
4KIT3.32483006
5NME22.94879918
6ZAK2.80720201
7STK162.78035747
8INSRR2.72019746
9MUSK2.62483236
10FLT32.53853132
11GRK12.32615194
12CDK192.28066813
13WEE12.20792624
14TEC2.16997278
15WNK42.14319639
16PIM22.11015004
17EIF2AK31.86916210
18NUAK11.86805314
19WNK31.82789204
20MAP4K21.82101204
21CAMKK21.60432795
22CSF1R1.58706874
23DAPK21.57831283
24MKNK21.56579016
25OXSR11.54974026
26BTK1.47975031
27CAMK11.46021375
28STK391.44474982
29MATK1.44439152
30ACVR1B1.39291838
31VRK11.37913046
32BRSK21.34644221
33MKNK11.34062497
34TGFBR11.30169736
35MAP4K11.29745310
36FES1.28021655
37ADRBK11.27883236
38DYRK31.23557335
39MAP3K121.19770409
40MAPK131.11863550
41MAP3K41.09249110
42TGFBR21.05594340
43PNCK1.03945829
44TIE11.00912159
45TLK10.99414197
46MAPKAPK50.96211542
47PIK3CA0.94165987
48TBK10.92828498
49MAP2K70.91385139
50IRAK40.90849760
51MAPK40.90714666
52STK38L0.89600139
53ITK0.86860299
54ADRBK20.86781410
55PAK30.84285108
56MAPK110.83321005
57SYK0.82133533
58ZAP700.81645928
59RPS6KB20.81636923
60SCYL20.79657300
61TYK20.76899733
62BCKDK0.74739965
63OBSCN0.74207039
64PRKCQ0.73969437
65KDR0.72900488
66SIK20.71853537
67RIPK40.70795568
68PRKG20.70415152
69PTK2B0.70166443
70STK30.69791091
71MAP3K60.69655230
72YES10.69592097
73IKBKE0.68867416
74PRKCE0.68818536
75BLK0.68742844
76BUB10.67803472
77MAP2K30.67252555
78EEF2K0.67169614
79IRAK10.67129905
80MAPKAPK30.66824557
81LYN0.66659091
82RPS6KA50.66197706
83EIF2AK20.65406571
84IRAK30.64408621
85IKBKB0.62866293
86NEK20.62348185
87JAK30.62043630
88RAF10.61683683
89CHUK0.60589239
90PKN10.60488085
91PRKCG0.60143357
92PHKG10.59511118
93PHKG20.59511118
94TAOK30.58929943
95CDK70.58680116
96CDK80.56541883
97CLK10.55565381
98TXK0.54789799
99LCK0.54186565
100CCNB10.53647020
101PIM10.52256922
102NTRK30.51792072
103DYRK20.50361793
104CHEK20.49805412
105SRPK10.49574213
106PRKAA20.49351574
107MAPK120.45762515
108HIPK20.45444418
109TRPM70.45134735
110CDK30.45091577
111GRK60.43508614
112MYLK0.42110878
113STK110.41580215
114NEK90.40103294
115LRRK20.40051186
116CAMK2A0.39789458
117DAPK10.39762560
118MAP2K20.39392829
119FGFR20.38952121
120PINK10.38935809
121PLK20.38893564
122PRKACA0.38803277
123BMPR1B0.38113433
124MAP3K70.37425680
125WNK10.37151062
126MAP2K10.36632357
127ERBB20.36396193
128MARK30.36126364
129RPS6KA60.35870400
130CSNK1D0.34081494
131CDK40.34010463
132PRKAA10.33825606
133BRSK10.32904980
134TRIM280.32442890
135EIF2AK10.31842991
136SGK20.31460698
137MAP3K110.31318807
138MAP2K60.29648443
139CSNK2A20.28321206
140MST40.27030095
141CSNK2A10.22720534
142PIK3CG0.20315126
143RPS6KA40.19961387
144CAMKK10.18761158
145ATR0.18082911
146MAPK150.17761120
147CSNK1G10.16818602
148CSNK1G30.16461855
149PAK40.16094222
150TNK20.15248883
151CASK0.15071226
152GRK70.14930271
153ILK0.14129076
154HCK0.13922436
155MAPK30.13585027

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.52965844
2DNA replication_Homo sapiens_hsa030304.72539091
3Thyroid cancer_Homo sapiens_hsa052162.96826622
4Phototransduction_Homo sapiens_hsa047442.90975797
5Protein export_Homo sapiens_hsa030602.86326203
6Mismatch repair_Homo sapiens_hsa034302.76995468
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.75830471
8Nitrogen metabolism_Homo sapiens_hsa009102.67468351
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.63467219
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.60124275
11Linoleic acid metabolism_Homo sapiens_hsa005912.57119171
12Pyrimidine metabolism_Homo sapiens_hsa002402.53341836
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.47418949
14RNA polymerase_Homo sapiens_hsa030202.46399701
15Base excision repair_Homo sapiens_hsa034102.42585864
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.39278537
17Homologous recombination_Homo sapiens_hsa034402.38981024
18Butanoate metabolism_Homo sapiens_hsa006502.36514305
19Selenocompound metabolism_Homo sapiens_hsa004502.24846193
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.20486039
21Nicotine addiction_Homo sapiens_hsa050332.14835015
22Sulfur relay system_Homo sapiens_hsa041222.14303043
23N-Glycan biosynthesis_Homo sapiens_hsa005102.04689132
24Spliceosome_Homo sapiens_hsa030402.01489527
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01143688
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00114076
27Primary immunodeficiency_Homo sapiens_hsa053401.93205774
28Tryptophan metabolism_Homo sapiens_hsa003801.93075371
29Nucleotide excision repair_Homo sapiens_hsa034201.92288042
30Ether lipid metabolism_Homo sapiens_hsa005651.71883282
31Proteasome_Homo sapiens_hsa030501.69356615
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.60546140
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.55051999
34Graft-versus-host disease_Homo sapiens_hsa053321.54266316
35Taste transduction_Homo sapiens_hsa047421.52622460
36Olfactory transduction_Homo sapiens_hsa047401.51917504
37Folate biosynthesis_Homo sapiens_hsa007901.51641942
38Acute myeloid leukemia_Homo sapiens_hsa052211.49763458
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43579445
40Purine metabolism_Homo sapiens_hsa002301.42844138
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42612248
42Hematopoietic cell lineage_Homo sapiens_hsa046401.41269361
43Morphine addiction_Homo sapiens_hsa050321.32648760
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31257468
45Non-homologous end-joining_Homo sapiens_hsa034501.31013238
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.30054838
47Other glycan degradation_Homo sapiens_hsa005111.29612337
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25788682
49Measles_Homo sapiens_hsa051621.25029391
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24599990
51Herpes simplex infection_Homo sapiens_hsa051681.24358967
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.23569634
53Autoimmune thyroid disease_Homo sapiens_hsa053201.20016571
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15322345
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.14277057
56p53 signaling pathway_Homo sapiens_hsa041151.13880714
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10114078
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08082599
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.06139800
60Leishmaniasis_Homo sapiens_hsa051401.05295906
61Type I diabetes mellitus_Homo sapiens_hsa049401.04769329
62B cell receptor signaling pathway_Homo sapiens_hsa046621.02375234
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01698501
64Serotonergic synapse_Homo sapiens_hsa047260.99539773
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99085120
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.98105528
67Chemical carcinogenesis_Homo sapiens_hsa052040.95634527
68Parkinsons disease_Homo sapiens_hsa050120.94992925
69Basal transcription factors_Homo sapiens_hsa030220.93302411
70Fanconi anemia pathway_Homo sapiens_hsa034600.92525241
71RNA degradation_Homo sapiens_hsa030180.92380213
72Caffeine metabolism_Homo sapiens_hsa002320.91992552
73Antigen processing and presentation_Homo sapiens_hsa046120.90471919
74Dorso-ventral axis formation_Homo sapiens_hsa043200.89604675
75Calcium signaling pathway_Homo sapiens_hsa040200.89406373
76Glycerolipid metabolism_Homo sapiens_hsa005610.89354018
77Histidine metabolism_Homo sapiens_hsa003400.87972079
78Ovarian steroidogenesis_Homo sapiens_hsa049130.86507390
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.86322274
80Circadian entrainment_Homo sapiens_hsa047130.86030414
81Allograft rejection_Homo sapiens_hsa053300.85899886
82Pentose phosphate pathway_Homo sapiens_hsa000300.85445088
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84389245
84Cell cycle_Homo sapiens_hsa041100.83750956
85Oxidative phosphorylation_Homo sapiens_hsa001900.83270500
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83042709
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83011536
88Peroxisome_Homo sapiens_hsa041460.81005043
89Glutamatergic synapse_Homo sapiens_hsa047240.78934067
90Retinol metabolism_Homo sapiens_hsa008300.74721788
91GABAergic synapse_Homo sapiens_hsa047270.71208996
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70406667
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69917756
94One carbon pool by folate_Homo sapiens_hsa006700.69909258
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69410476
96Propanoate metabolism_Homo sapiens_hsa006400.65838178
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65445013
98Systemic lupus erythematosus_Homo sapiens_hsa053220.65372803
99Salivary secretion_Homo sapiens_hsa049700.65139548
100Insulin secretion_Homo sapiens_hsa049110.65120313
101Vitamin digestion and absorption_Homo sapiens_hsa049770.62155227
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.60480792
103RNA transport_Homo sapiens_hsa030130.59896689
104Pertussis_Homo sapiens_hsa051330.58353001
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57638639
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52769271
107beta-Alanine metabolism_Homo sapiens_hsa004100.52423568
108Asthma_Homo sapiens_hsa053100.52396265
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52024312
110Malaria_Homo sapiens_hsa051440.51790671
111Long-term depression_Homo sapiens_hsa047300.50321929
112Influenza A_Homo sapiens_hsa051640.49442971
113Huntingtons disease_Homo sapiens_hsa050160.49427714
114Platelet activation_Homo sapiens_hsa046110.48395890
115Shigellosis_Homo sapiens_hsa051310.47852024
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.46890078
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46300744
118Epstein-Barr virus infection_Homo sapiens_hsa051690.45080984
119Metabolic pathways_Homo sapiens_hsa011000.44673134
120Cardiac muscle contraction_Homo sapiens_hsa042600.43890987
121ABC transporters_Homo sapiens_hsa020100.43421153
122Legionellosis_Homo sapiens_hsa051340.43228385
123Arachidonic acid metabolism_Homo sapiens_hsa005900.43099146
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42827354
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42777799
126T cell receptor signaling pathway_Homo sapiens_hsa046600.42131650
127Hepatitis B_Homo sapiens_hsa051610.40903588
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40660986
129Lysine degradation_Homo sapiens_hsa003100.40285502
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38145782
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.35973660
132cAMP signaling pathway_Homo sapiens_hsa040240.35659392
133Osteoclast differentiation_Homo sapiens_hsa043800.35309104
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.35223345
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33722571
136Cholinergic synapse_Homo sapiens_hsa047250.33419093
137Alzheimers disease_Homo sapiens_hsa050100.32673068
138Colorectal cancer_Homo sapiens_hsa052100.32670097
139Oxytocin signaling pathway_Homo sapiens_hsa049210.31704116
140Staphylococcus aureus infection_Homo sapiens_hsa051500.31525707
141Fatty acid biosynthesis_Homo sapiens_hsa000610.30983767
142Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30401503
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29425711
144Toxoplasmosis_Homo sapiens_hsa051450.28174115
145Regulation of autophagy_Homo sapiens_hsa041400.27617211
146Alcoholism_Homo sapiens_hsa050340.26744971
147Tuberculosis_Homo sapiens_hsa051520.24439150
148African trypanosomiasis_Homo sapiens_hsa051430.23058784
149Viral carcinogenesis_Homo sapiens_hsa052030.22370869
150Fatty acid elongation_Homo sapiens_hsa000620.21497780
151Apoptosis_Homo sapiens_hsa042100.21087823
152Glycosaminoglycan degradation_Homo sapiens_hsa005310.19781589
153Cysteine and methionine metabolism_Homo sapiens_hsa002700.19346046
154Sphingolipid metabolism_Homo sapiens_hsa006000.19239625
155Salmonella infection_Homo sapiens_hsa051320.18525382
156Glutathione metabolism_Homo sapiens_hsa004800.17725757
157Galactose metabolism_Homo sapiens_hsa000520.17334445
158Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15005410

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