

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.66993516 |
| 2 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 5.37814917 |
| 3 | termination of RNA polymerase III transcription (GO:0006386) | 5.37814917 |
| 4 | respiratory electron transport chain (GO:0022904) | 5.31156284 |
| 5 | electron transport chain (GO:0022900) | 5.22283791 |
| 6 | 7-methylguanosine mRNA capping (GO:0006370) | 5.08113361 |
| 7 | 7-methylguanosine RNA capping (GO:0009452) | 4.95877135 |
| 8 | RNA capping (GO:0036260) | 4.95877135 |
| 9 | ribosome assembly (GO:0042255) | 4.75752755 |
| 10 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.74317120 |
| 11 | rRNA modification (GO:0000154) | 4.71983905 |
| 12 | protein complex biogenesis (GO:0070271) | 4.65287989 |
| 13 | purine nucleobase biosynthetic process (GO:0009113) | 4.60900383 |
| 14 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 4.56582870 |
| 15 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.54707952 |
| 16 | translational termination (GO:0006415) | 4.54480658 |
| 17 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.52219437 |
| 18 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.50904724 |
| 19 | viral transcription (GO:0019083) | 4.48231632 |
| 20 | protein neddylation (GO:0045116) | 4.48097470 |
| 21 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.45165793 |
| 22 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.44302519 |
| 23 | NADH dehydrogenase complex assembly (GO:0010257) | 4.44302519 |
| 24 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.44302519 |
| 25 | chaperone-mediated protein transport (GO:0072321) | 4.40888756 |
| 26 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.40157965 |
| 27 | termination of RNA polymerase I transcription (GO:0006363) | 4.36329537 |
| 28 | transcription from RNA polymerase I promoter (GO:0006360) | 4.25444816 |
| 29 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.23871314 |
| 30 | cotranslational protein targeting to membrane (GO:0006613) | 4.22877738 |
| 31 | protein targeting to ER (GO:0045047) | 4.16516103 |
| 32 | respiratory chain complex IV assembly (GO:0008535) | 4.09089186 |
| 33 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.08679041 |
| 34 | mitotic metaphase plate congression (GO:0007080) | 4.08128365 |
| 35 | negative regulation of ligase activity (GO:0051352) | 4.07528651 |
| 36 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.07528651 |
| 37 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 4.06752559 |
| 38 | amino acid salvage (GO:0043102) | 4.01397969 |
| 39 | L-methionine salvage (GO:0071267) | 4.01397969 |
| 40 | L-methionine biosynthetic process (GO:0071265) | 4.01397969 |
| 41 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.00900349 |
| 42 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.00039685 |
| 43 | ribosome biogenesis (GO:0042254) | 3.99356038 |
| 44 | protein localization to endoplasmic reticulum (GO:0070972) | 3.94113168 |
| 45 | nucleobase biosynthetic process (GO:0046112) | 3.91493079 |
| 46 | translation (GO:0006412) | 3.86928035 |
| 47 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.86598325 |
| 48 | positive regulation of ligase activity (GO:0051351) | 3.85749650 |
| 49 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.83359061 |
| 50 | cytochrome complex assembly (GO:0017004) | 3.80917877 |
| 51 | cullin deneddylation (GO:0010388) | 3.80228081 |
| 52 | ribosomal small subunit assembly (GO:0000028) | 3.80026114 |
| 53 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.78577464 |
| 54 | regulation of mitochondrial translation (GO:0070129) | 3.77778914 |
| 55 | translational elongation (GO:0006414) | 3.75796020 |
| 56 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.74843208 |
| 57 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.73441259 |
| 58 | protein deneddylation (GO:0000338) | 3.72692815 |
| 59 | protein targeting to mitochondrion (GO:0006626) | 3.66395340 |
| 60 | establishment of protein localization to mitochondrion (GO:0072655) | 3.65577405 |
| 61 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.64802075 |
| 62 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.62120256 |
| 63 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.62120256 |
| 64 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.62120256 |
| 65 | maturation of SSU-rRNA (GO:0030490) | 3.60811364 |
| 66 | maturation of 5.8S rRNA (GO:0000460) | 3.60487472 |
| 67 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.59115535 |
| 68 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.58560151 |
| 69 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.58560151 |
| 70 | rRNA methylation (GO:0031167) | 3.58286418 |
| 71 | translational initiation (GO:0006413) | 3.57560953 |
| 72 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.56544887 |
| 73 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.56544887 |
| 74 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.56469534 |
| 75 | hydrogen ion transmembrane transport (GO:1902600) | 3.55793436 |
| 76 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.54489370 |
| 77 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.53767076 |
| 78 | ATP synthesis coupled proton transport (GO:0015986) | 3.53761935 |
| 79 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.53761935 |
| 80 | blastocyst development (GO:0001824) | 3.52410437 |
| 81 | protein localization to mitochondrion (GO:0070585) | 3.51894136 |
| 82 | DNA deamination (GO:0045006) | 3.50217984 |
| 83 | ATP biosynthetic process (GO:0006754) | 3.46490222 |
| 84 | cellular protein complex disassembly (GO:0043624) | 3.46410864 |
| 85 | rRNA processing (GO:0006364) | 3.45165814 |
| 86 | spliceosomal snRNP assembly (GO:0000387) | 3.44614699 |
| 87 | viral life cycle (GO:0019058) | 3.42438140 |
| 88 | regulation of ligase activity (GO:0051340) | 3.38433733 |
| 89 | signal peptide processing (GO:0006465) | 3.37822481 |
| 90 | DNA replication checkpoint (GO:0000076) | 3.34175607 |
| 91 | * DNA-templated transcription, elongation (GO:0006354) | 3.32886063 |
| 92 | * transcription elongation from RNA polymerase II promoter (GO:0006368) | 3.32837425 |
| 93 | rRNA metabolic process (GO:0016072) | 3.32725686 |
| 94 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.32460343 |
| 95 | ribosomal large subunit biogenesis (GO:0042273) | 3.31913349 |
| 96 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.31475741 |
| 97 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.26240990 |
| 98 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.25783247 |
| 99 | cellular component biogenesis (GO:0044085) | 3.24068090 |
| 100 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.18826817 |
| 101 | proton transport (GO:0015992) | 3.18442809 |
| 102 | peptidyl-histidine modification (GO:0018202) | 3.12376970 |
| 103 | DNA damage response, detection of DNA damage (GO:0042769) | 3.12095238 |
| 104 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.11749758 |
| 105 | regulation of cellular amine metabolic process (GO:0033238) | 3.10983749 |
| 106 | hydrogen transport (GO:0006818) | 3.10430432 |
| 107 | microtubule depolymerization (GO:0007019) | 3.09992392 |
| 108 | GTP biosynthetic process (GO:0006183) | 3.08954165 |
| 109 | intracellular protein transmembrane import (GO:0044743) | 3.08917963 |
| 110 | formation of translation preinitiation complex (GO:0001731) | 3.08739298 |
| 111 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.08031909 |
| 112 | transcription from mitochondrial promoter (GO:0006390) | 3.07262811 |
| 113 | CENP-A containing nucleosome assembly (GO:0034080) | 3.07047814 |
| 114 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.05919851 |
| 115 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.05919851 |
| 116 | protein-cofactor linkage (GO:0018065) | 3.05171100 |
| 117 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.02679824 |
| 118 | cell cycle G1/S phase transition (GO:0044843) | 3.02679824 |
| 119 | DNA double-strand break processing (GO:0000729) | 3.02284407 |
| 120 | metaphase plate congression (GO:0051310) | 3.01809618 |
| 121 | spliceosomal complex assembly (GO:0000245) | 2.99470758 |
| 122 | GMP metabolic process (GO:0046037) | 2.99011896 |
| 123 | tRNA processing (GO:0008033) | 2.98473799 |
| 124 | mitochondrial transport (GO:0006839) | 2.97378437 |
| 125 | organelle disassembly (GO:1903008) | 2.96368587 |
| 126 | pseudouridine synthesis (GO:0001522) | 2.94671752 |
| 127 | methionine biosynthetic process (GO:0009086) | 2.93919569 |
| 128 | * positive regulation of viral transcription (GO:0050434) | 2.93872405 |
| 129 | folic acid transport (GO:0015884) | 2.93184494 |
| 130 | positive regulation of mitochondrial fission (GO:0090141) | 2.92607550 |
| 131 | histone exchange (GO:0043486) | 2.91214356 |
| 132 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.90574635 |
| 133 | ribosomal small subunit biogenesis (GO:0042274) | 2.89673759 |
| 134 | histone mRNA metabolic process (GO:0008334) | 2.85638054 |
| 135 | kinetochore assembly (GO:0051382) | 2.85471390 |
| 136 | protein K6-linked ubiquitination (GO:0085020) | 2.85443992 |
| 137 | transcription from RNA polymerase III promoter (GO:0006383) | 2.84783046 |
| 138 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.84782876 |
| 139 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.84782876 |
| 140 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.84029518 |
| 141 | positive regulation of cell cycle arrest (GO:0071158) | 2.82901576 |
| 142 | negative regulation of protein ubiquitination (GO:0031397) | 2.81577912 |
| 143 | regulation of spindle organization (GO:0090224) | 2.81459910 |
| 144 | chromatin remodeling at centromere (GO:0031055) | 2.80168907 |
| 145 | lung-associated mesenchyme development (GO:0060484) | 2.80157496 |
| 146 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.79222416 |
| 147 | keratinocyte development (GO:0003334) | 2.79102100 |
| 148 | protein complex disassembly (GO:0043241) | 2.77157749 |
| 149 | ncRNA processing (GO:0034470) | 2.76451410 |
| 150 | recombinational repair (GO:0000725) | 2.75758288 |
| 151 | replication fork processing (GO:0031297) | 2.75373202 |
| 152 | kynurenine metabolic process (GO:0070189) | 2.75139747 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 6.05446571 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.96059646 |
| 3 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.32084955 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.21099426 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.11589021 |
| 6 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.92446144 |
| 7 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.90284155 |
| 8 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.54563202 |
| 9 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.53229961 |
| 10 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.35900952 |
| 11 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.07521109 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.81157301 |
| 13 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.74693746 |
| 14 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.71275032 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.65723131 |
| 16 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.64175499 |
| 17 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.64144171 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.50228751 |
| 19 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.45722750 |
| 20 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.26991810 |
| 21 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.26756937 |
| 22 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.17931822 |
| 23 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.13832015 |
| 24 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.12599451 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.09017103 |
| 26 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.08428935 |
| 27 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.08181608 |
| 28 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.02964428 |
| 29 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.01002254 |
| 30 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.98983767 |
| 31 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.95945373 |
| 32 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.94749311 |
| 33 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.94438159 |
| 34 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.90306219 |
| 35 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.88641144 |
| 36 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.86806073 |
| 37 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.85029854 |
| 38 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.82632473 |
| 39 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.73636535 |
| 40 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.72089071 |
| 41 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.71048304 |
| 42 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.71015523 |
| 43 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.64916676 |
| 44 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.60851771 |
| 45 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.58818912 |
| 46 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.58177040 |
| 47 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.54740141 |
| 48 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.47425357 |
| 49 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.42860264 |
| 50 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.41851177 |
| 51 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.41117072 |
| 52 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.35121570 |
| 53 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.34284780 |
| 54 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.30966776 |
| 55 | P300_19829295_ChIP-Seq_ESCs_Human | 1.27600159 |
| 56 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.25968662 |
| 57 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.25930855 |
| 58 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.25467623 |
| 59 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.24839587 |
| 60 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.22798401 |
| 61 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.21668460 |
| 62 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.21201317 |
| 63 | * EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.21081422 |
| 64 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.19564490 |
| 65 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.19310320 |
| 66 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.13855308 |
| 67 | * FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.13198353 |
| 68 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.12537322 |
| 69 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.12252130 |
| 70 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.11732446 |
| 71 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.10278564 |
| 72 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.09352043 |
| 73 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.09172767 |
| 74 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.07970781 |
| 75 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.07313907 |
| 76 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.06684362 |
| 77 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.06200205 |
| 78 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.04893253 |
| 79 | VDR_22108803_ChIP-Seq_LS180_Human | 1.03518004 |
| 80 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.01062493 |
| 81 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.00084452 |
| 82 | * PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.97244992 |
| 83 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.96872454 |
| 84 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.96872454 |
| 85 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.93227213 |
| 86 | * NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.91217213 |
| 87 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.90811688 |
| 88 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.90589347 |
| 89 | AR_20517297_ChIP-Seq_VCAP_Human | 0.90444126 |
| 90 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.89303810 |
| 91 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.87664987 |
| 92 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.86366682 |
| 93 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.85801971 |
| 94 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.85801971 |
| 95 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.85233052 |
| 96 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.85179242 |
| 97 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.85061529 |
| 98 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.84676940 |
| 99 | * CBP_20019798_ChIP-Seq_JUKART_Human | 0.84402744 |
| 100 | * IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.84402744 |
| 101 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.83785021 |
| 102 | FUS_26573619_Chip-Seq_HEK293_Human | 0.82421849 |
| 103 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.81957234 |
| 104 | NCOR_22424771_ChIP-Seq_293T_Human | 0.81139021 |
| 105 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.80992052 |
| 106 | * SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.77857330 |
| 107 | * NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.77152232 |
| 108 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.77134067 |
| 109 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.76525538 |
| 110 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.76440993 |
| 111 | * EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.76117534 |
| 112 | * NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.75046102 |
| 113 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.70069597 |
| 114 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.69832995 |
| 115 | EWS_26573619_Chip-Seq_HEK293_Human | 0.69780838 |
| 116 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.69407787 |
| 117 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.68935030 |
| 118 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.68781417 |
| 119 | * TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.68477445 |
| 120 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.68044918 |
| 121 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.67002685 |
| 122 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.66966499 |
| 123 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.66533580 |
| 124 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.66053977 |
| 125 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.65632884 |
| 126 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.65397869 |
| 127 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.65294849 |
| 128 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.65152098 |
| 129 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.62066076 |
| 130 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.61616517 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.51763830 |
| 2 | MP0003718_maternal_effect | 4.31612491 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 3.88795518 |
| 4 | MP0008260_abnormal_autophagy | 3.60730541 |
| 5 | MP0003880_abnormal_central_pattern | 3.26354776 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 3.12819552 |
| 7 | MP0003111_abnormal_nucleus_morphology | 2.93752730 |
| 8 | MP0001529_abnormal_vocalization | 2.68505232 |
| 9 | MP0002938_white_spotting | 2.53184205 |
| 10 | MP0002837_dystrophic_cardiac_calcinosis | 2.44478498 |
| 11 | MP0003186_abnormal_redox_activity | 2.42801881 |
| 12 | MP0010094_abnormal_chromosome_stability | 2.40326146 |
| 13 | MP0008877_abnormal_DNA_methylation | 2.35151295 |
| 14 | MP0001905_abnormal_dopamine_level | 2.32759453 |
| 15 | MP0003077_abnormal_cell_cycle | 2.27683523 |
| 16 | MP0008058_abnormal_DNA_repair | 2.24003348 |
| 17 | MP0008932_abnormal_embryonic_tissue | 2.22837291 |
| 18 | MP0003786_premature_aging | 2.19767676 |
| 19 | MP0003136_yellow_coat_color | 2.15235525 |
| 20 | MP0003195_calcinosis | 2.15078179 |
| 21 | MP0003123_paternal_imprinting | 2.05864366 |
| 22 | MP0008057_abnormal_DNA_replication | 2.02355651 |
| 23 | MP0006072_abnormal_retinal_apoptosis | 2.00990130 |
| 24 | MP0009046_muscle_twitch | 2.00883449 |
| 25 | MP0003315_abnormal_perineum_morphology | 1.93841376 |
| 26 | MP0000569_abnormal_digit_pigmentation | 1.81164528 |
| 27 | MP0001440_abnormal_grooming_behavior | 1.78699833 |
| 28 | MP0001188_hyperpigmentation | 1.73721891 |
| 29 | MP0001542_abnormal_bone_strength | 1.71163847 |
| 30 | MP0002734_abnormal_mechanical_nocicepti | 1.68432194 |
| 31 | MP0002163_abnormal_gland_morphology | 1.64995504 |
| 32 | MP0006292_abnormal_olfactory_placode | 1.61468152 |
| 33 | MP0002102_abnormal_ear_morphology | 1.60245746 |
| 34 | MP0004270_analgesia | 1.59769712 |
| 35 | MP0005551_abnormal_eye_electrophysiolog | 1.55432670 |
| 36 | MP0001968_abnormal_touch/_nociception | 1.54300450 |
| 37 | MP0006035_abnormal_mitochondrial_morpho | 1.49545261 |
| 38 | MP0004859_abnormal_synaptic_plasticity | 1.47016627 |
| 39 | MP0003950_abnormal_plasma_membrane | 1.46448125 |
| 40 | MP0002736_abnormal_nociception_after | 1.46072957 |
| 41 | MP0006276_abnormal_autonomic_nervous | 1.45989862 |
| 42 | MP0001764_abnormal_homeostasis | 1.44101645 |
| 43 | MP0003646_muscle_fatigue | 1.43924967 |
| 44 | MP0005395_other_phenotype | 1.42275973 |
| 45 | MP0005084_abnormal_gallbladder_morpholo | 1.40330421 |
| 46 | MP0005253_abnormal_eye_physiology | 1.40054515 |
| 47 | MP0002272_abnormal_nervous_system | 1.37966922 |
| 48 | MP0008875_abnormal_xenobiotic_pharmacok | 1.35877433 |
| 49 | MP0003938_abnormal_ear_development | 1.34928420 |
| 50 | MP0004145_abnormal_muscle_electrophysio | 1.32810523 |
| 51 | MP0003635_abnormal_synaptic_transmissio | 1.32590982 |
| 52 | MP0002064_seizures | 1.32549715 |
| 53 | MP0002210_abnormal_sex_determination | 1.30912999 |
| 54 | MP0002735_abnormal_chemical_nociception | 1.26173139 |
| 55 | MP0001984_abnormal_olfaction | 1.24911570 |
| 56 | MP0009745_abnormal_behavioral_response | 1.24210752 |
| 57 | MP0009379_abnormal_foot_pigmentation | 1.24120801 |
| 58 | MP0001986_abnormal_taste_sensitivity | 1.22534231 |
| 59 | MP0001661_extended_life_span | 1.22394406 |
| 60 | MP0003011_delayed_dark_adaptation | 1.22097923 |
| 61 | MP0001929_abnormal_gametogenesis | 1.22068845 |
| 62 | MP0005646_abnormal_pituitary_gland | 1.21990699 |
| 63 | MP0008872_abnormal_physiological_respon | 1.20076826 |
| 64 | MP0001970_abnormal_pain_threshold | 1.19017730 |
| 65 | MP0008007_abnormal_cellular_replicative | 1.18824206 |
| 66 | MP0006036_abnormal_mitochondrial_physio | 1.18817885 |
| 67 | MP0001730_embryonic_growth_arrest | 1.18527013 |
| 68 | MP0000631_abnormal_neuroendocrine_gland | 1.17903194 |
| 69 | MP0001485_abnormal_pinna_reflex | 1.16579885 |
| 70 | MP0002277_abnormal_respiratory_mucosa | 1.16553534 |
| 71 | MP0002572_abnormal_emotion/affect_behav | 1.16218865 |
| 72 | MP0001293_anophthalmia | 1.13578634 |
| 73 | MP0002234_abnormal_pharynx_morphology | 1.13378644 |
| 74 | MP0005423_abnormal_somatic_nervous | 1.12939325 |
| 75 | MP0005266_abnormal_metabolism | 1.12696653 |
| 76 | MP0003879_abnormal_hair_cell | 1.11503363 |
| 77 | MP0002095_abnormal_skin_pigmentation | 1.11204955 |
| 78 | MP0005408_hypopigmentation | 1.10654486 |
| 79 | MP0002160_abnormal_reproductive_system | 1.09968549 |
| 80 | MP0003941_abnormal_skin_development | 1.09401540 |
| 81 | MP0002090_abnormal_vision | 1.09218785 |
| 82 | MP0004142_abnormal_muscle_tone | 1.09008303 |
| 83 | MP0001501_abnormal_sleep_pattern | 1.08907109 |
| 84 | MP0002063_abnormal_learning/memory/cond | 1.08390021 |
| 85 | MP0001145_abnormal_male_reproductive | 1.05607239 |
| 86 | MP0005389_reproductive_system_phenotype | 1.05468656 |
| 87 | MP0001486_abnormal_startle_reflex | 1.05264107 |
| 88 | MP0002067_abnormal_sensory_capabilities | 1.04502153 |
| 89 | MP0000372_irregular_coat_pigmentation | 1.03026108 |
| 90 | MP0000653_abnormal_sex_gland | 1.02941937 |
| 91 | MP0000750_abnormal_muscle_regeneration | 1.01382418 |
| 92 | MP0002638_abnormal_pupillary_reflex | 1.00913059 |
| 93 | MP0000427_abnormal_hair_cycle | 0.99548187 |
| 94 | MP0001727_abnormal_embryo_implantation | 0.99321581 |
| 95 | MP0003698_abnormal_male_reproductive | 0.99189396 |
| 96 | MP0002184_abnormal_innervation | 0.99060865 |
| 97 | MP0002733_abnormal_thermal_nociception | 0.97612868 |
| 98 | MP0005451_abnormal_body_composition | 0.95887840 |
| 99 | MP0005171_absent_coat_pigmentation | 0.93277041 |
| 100 | MP0003137_abnormal_impulse_conducting | 0.92708159 |
| 101 | MP0002876_abnormal_thyroid_physiology | 0.92641047 |
| 102 | MP0004147_increased_porphyrin_level | 0.92391236 |
| 103 | MP0004924_abnormal_behavior | 0.90927791 |
| 104 | MP0005386_behavior/neurological_phenoty | 0.90927791 |
| 105 | MP0005410_abnormal_fertilization | 0.90764821 |
| 106 | MP0000647_abnormal_sebaceous_gland | 0.89317354 |
| 107 | MP0005645_abnormal_hypothalamus_physiol | 0.88526035 |
| 108 | MP0003890_abnormal_embryonic-extraembry | 0.87009735 |
| 109 | MP0005332_abnormal_amino_acid | 0.85954882 |
| 110 | MP0000350_abnormal_cell_proliferation | 0.85394608 |
| 111 | MP0002653_abnormal_ependyma_morphology | 0.84460237 |
| 112 | MP0003221_abnormal_cardiomyocyte_apopto | 0.82590746 |
| 113 | MP0004133_heterotaxia | 0.82430306 |
| 114 | MP0003878_abnormal_ear_physiology | 0.81807564 |
| 115 | MP0005377_hearing/vestibular/ear_phenot | 0.81807564 |
| 116 | MP0000049_abnormal_middle_ear | 0.81534248 |
| 117 | MP0005379_endocrine/exocrine_gland_phen | 0.81220871 |
| 118 | MP0000778_abnormal_nervous_system | 0.80552791 |
| 119 | MP0010030_abnormal_orbit_morphology | 0.80481693 |
| 120 | MP0005195_abnormal_posterior_eye | 0.80435164 |
| 121 | MP0003937_abnormal_limbs/digits/tail_de | 0.79528192 |
| 122 | MP0001919_abnormal_reproductive_system | 0.79200260 |
| 123 | MP0009697_abnormal_copulation | 0.79105970 |
| 124 | MP0003329_amyloid_beta_deposits | 0.78525831 |
| 125 | MP0009333_abnormal_splenocyte_physiolog | 0.77717216 |
| 126 | MP0002161_abnormal_fertility/fecundity | 0.77326805 |
| 127 | MP0010386_abnormal_urinary_bladder | 0.77250911 |
| 128 | MP0005174_abnormal_tail_pigmentation | 0.77129451 |
| 129 | MP0000358_abnormal_cell_content/ | 0.76135359 |
| 130 | MP0002751_abnormal_autonomic_nervous | 0.75564459 |
| 131 | MP0004043_abnormal_pH_regulation | 0.75473962 |
| 132 | MP0004215_abnormal_myocardial_fiber | 0.75367585 |
| 133 | MP0002066_abnormal_motor_capabilities/c | 0.73094680 |
| 134 | MP0004381_abnormal_hair_follicle | 0.72674519 |
| 135 | MP0001963_abnormal_hearing_physiology | 0.72472417 |
| 136 | MP0005499_abnormal_olfactory_system | 0.69506573 |
| 137 | MP0005394_taste/olfaction_phenotype | 0.69506573 |
| 138 | MP0008789_abnormal_olfactory_epithelium | 0.69378956 |
| 139 | MP0004084_abnormal_cardiac_muscle | 0.68578826 |
| 140 | MP0002752_abnormal_somatic_nervous | 0.68088198 |
| 141 | MP0004742_abnormal_vestibular_system | 0.67111850 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Cerebral hypomyelination (HP:0006808) | 4.69771230 |
| 2 | Birth length less than 3rd percentile (HP:0003561) | 4.56321820 |
| 3 | Breast hypoplasia (HP:0003187) | 4.22317230 |
| 4 | Cerebral edema (HP:0002181) | 3.70850895 |
| 5 | Acute necrotizing encephalopathy (HP:0006965) | 3.69205202 |
| 6 | Carpal bone hypoplasia (HP:0001498) | 3.60733422 |
| 7 | 3-Methylglutaconic aciduria (HP:0003535) | 3.37297575 |
| 8 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.33807272 |
| 9 | Mitochondrial inheritance (HP:0001427) | 3.29104755 |
| 10 | Rough bone trabeculation (HP:0100670) | 3.28369564 |
| 11 | Increased serum pyruvate (HP:0003542) | 3.27194548 |
| 12 | Abnormality of glycolysis (HP:0004366) | 3.27194548 |
| 13 | Delusions (HP:0000746) | 3.21367881 |
| 14 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.15629130 |
| 15 | Abnormality of the labia minora (HP:0012880) | 3.07794570 |
| 16 | Abnormality of alanine metabolism (HP:0010916) | 3.05727206 |
| 17 | Hyperalaninemia (HP:0003348) | 3.05727206 |
| 18 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.05727206 |
| 19 | CNS hypomyelination (HP:0003429) | 3.01477391 |
| 20 | Increased CSF lactate (HP:0002490) | 3.00554495 |
| 21 | Progressive macrocephaly (HP:0004481) | 3.00283797 |
| 22 | Molar tooth sign on MRI (HP:0002419) | 2.92924004 |
| 23 | Abnormality of midbrain morphology (HP:0002418) | 2.92924004 |
| 24 | Hepatocellular necrosis (HP:0001404) | 2.87453331 |
| 25 | Exertional dyspnea (HP:0002875) | 2.87301274 |
| 26 | Secondary amenorrhea (HP:0000869) | 2.86518199 |
| 27 | Optic disc pallor (HP:0000543) | 2.85452835 |
| 28 | Increased intramyocellular lipid droplets (HP:0012240) | 2.83686472 |
| 29 | Acute encephalopathy (HP:0006846) | 2.78872794 |
| 30 | Increased hepatocellular lipid droplets (HP:0006565) | 2.78861306 |
| 31 | Impulsivity (HP:0100710) | 2.73333741 |
| 32 | Hyperglycinemia (HP:0002154) | 2.72779735 |
| 33 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.71313091 |
| 34 | Patellar aplasia (HP:0006443) | 2.69246193 |
| 35 | True hermaphroditism (HP:0010459) | 2.68979031 |
| 36 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.68281329 |
| 37 | Methylmalonic acidemia (HP:0002912) | 2.65834837 |
| 38 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.64278084 |
| 39 | Type I transferrin isoform profile (HP:0003642) | 2.61632721 |
| 40 | Methylmalonic aciduria (HP:0012120) | 2.56958019 |
| 41 | Abnormality of the umbilical cord (HP:0010881) | 2.56345403 |
| 42 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.54515207 |
| 43 | Ureteral duplication (HP:0000073) | 2.54168313 |
| 44 | Abnormal trabecular bone morphology (HP:0100671) | 2.52993398 |
| 45 | Increased serum lactate (HP:0002151) | 2.49432354 |
| 46 | Reticulocytopenia (HP:0001896) | 2.48016031 |
| 47 | Abnormality of renal resorption (HP:0011038) | 2.48015848 |
| 48 | Premature ovarian failure (HP:0008209) | 2.45282204 |
| 49 | Pancreatic fibrosis (HP:0100732) | 2.44745005 |
| 50 | Focal motor seizures (HP:0011153) | 2.43615860 |
| 51 | Irregular epiphyses (HP:0010582) | 2.39012847 |
| 52 | Aplastic anemia (HP:0001915) | 2.36266965 |
| 53 | CNS demyelination (HP:0007305) | 2.35898420 |
| 54 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.35058959 |
| 55 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.35058959 |
| 56 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.34402804 |
| 57 | Absent radius (HP:0003974) | 2.33805256 |
| 58 | Postnatal microcephaly (HP:0005484) | 2.33546248 |
| 59 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.31329552 |
| 60 | Hepatic necrosis (HP:0002605) | 2.30955058 |
| 61 | Increased muscle lipid content (HP:0009058) | 2.28858039 |
| 62 | Lethargy (HP:0001254) | 2.27452584 |
| 63 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.24937478 |
| 64 | Congenital, generalized hypertrichosis (HP:0004540) | 2.24400203 |
| 65 | Absent forearm bone (HP:0003953) | 2.22307695 |
| 66 | Aplasia involving forearm bones (HP:0009822) | 2.22307695 |
| 67 | Nephronophthisis (HP:0000090) | 2.20539377 |
| 68 | Parakeratosis (HP:0001036) | 2.19936278 |
| 69 | Lipid accumulation in hepatocytes (HP:0006561) | 2.19796010 |
| 70 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.19722461 |
| 71 | Renal Fanconi syndrome (HP:0001994) | 2.18750740 |
| 72 | Unsteady gait (HP:0002317) | 2.18616478 |
| 73 | Generalized aminoaciduria (HP:0002909) | 2.18106864 |
| 74 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.15892444 |
| 75 | Dysautonomia (HP:0002459) | 2.15755383 |
| 76 | Abnormality of methionine metabolism (HP:0010901) | 2.14739297 |
| 77 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.12930413 |
| 78 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.12930413 |
| 79 | Abnormal protein glycosylation (HP:0012346) | 2.12930413 |
| 80 | Abnormal glycosylation (HP:0012345) | 2.12930413 |
| 81 | Abnormality of urine glucose concentration (HP:0011016) | 2.11882306 |
| 82 | Glycosuria (HP:0003076) | 2.11882306 |
| 83 | Abnormal number of erythroid precursors (HP:0012131) | 2.11179308 |
| 84 | Macrocytic anemia (HP:0001972) | 2.11143591 |
| 85 | Pallor (HP:0000980) | 2.08883480 |
| 86 | Abnormal spermatogenesis (HP:0008669) | 2.07512018 |
| 87 | Congenital stationary night blindness (HP:0007642) | 2.05156825 |
| 88 | Lactic acidosis (HP:0003128) | 2.04956921 |
| 89 | Sparse eyelashes (HP:0000653) | 2.04683323 |
| 90 | Respiratory failure (HP:0002878) | 2.03425788 |
| 91 | Respiratory difficulties (HP:0002880) | 2.01522373 |
| 92 | Type 2 muscle fiber atrophy (HP:0003554) | 2.00093053 |
| 93 | Abnormal autonomic nervous system physiology (HP:0012332) | 1.99168873 |
| 94 | Emotional lability (HP:0000712) | 1.98652900 |
| 95 | Horseshoe kidney (HP:0000085) | 1.98460932 |
| 96 | Sclerocornea (HP:0000647) | 1.98226622 |
| 97 | Areflexia of lower limbs (HP:0002522) | 1.98012954 |
| 98 | X-linked dominant inheritance (HP:0001423) | 1.97064583 |
| 99 | Brittle hair (HP:0002299) | 1.96144021 |
| 100 | Pancreatic cysts (HP:0001737) | 1.95736486 |
| 101 | Patent foramen ovale (HP:0001655) | 1.95122239 |
| 102 | Degeneration of anterior horn cells (HP:0002398) | 1.94762132 |
| 103 | Abnormality of the anterior horn cell (HP:0006802) | 1.94762132 |
| 104 | Oral leukoplakia (HP:0002745) | 1.94252319 |
| 105 | Death in infancy (HP:0001522) | 1.94031470 |
| 106 | Hypoplasia of the pons (HP:0012110) | 1.93843598 |
| 107 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.93554055 |
| 108 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.93368974 |
| 109 | Split foot (HP:0001839) | 1.93297576 |
| 110 | Colon cancer (HP:0003003) | 1.91891863 |
| 111 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.91201534 |
| 112 | Abnormality of the pons (HP:0007361) | 1.91000526 |
| 113 | Adrenal hypoplasia (HP:0000835) | 1.89626064 |
| 114 | Breast aplasia (HP:0100783) | 1.89238612 |
| 115 | Exercise intolerance (HP:0003546) | 1.87610094 |
| 116 | Abnormality of the preputium (HP:0100587) | 1.87542803 |
| 117 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.87234388 |
| 118 | Absent epiphyses (HP:0010577) | 1.87234388 |
| 119 | Reduced antithrombin III activity (HP:0001976) | 1.86555117 |
| 120 | Progressive external ophthalmoplegia (HP:0000590) | 1.85818759 |
| 121 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.85259656 |
| 122 | Shoulder girdle muscle weakness (HP:0003547) | 1.85071675 |
| 123 | Abnormality of serum amino acid levels (HP:0003112) | 1.83682004 |
| 124 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.83444972 |
| 125 | Meckel diverticulum (HP:0002245) | 1.83178372 |
| 126 | Stenosis of the external auditory canal (HP:0000402) | 1.81774638 |
| 127 | Double outlet right ventricle (HP:0001719) | 1.81042999 |
| 128 | Congenital malformation of the right heart (HP:0011723) | 1.81042999 |
| 129 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 1.80708317 |
| 130 | Abnormality of the renal medulla (HP:0100957) | 1.80551715 |
| 131 | Medial flaring of the eyebrow (HP:0010747) | 1.80539200 |
| 132 | Prolonged neonatal jaundice (HP:0006579) | 1.80197864 |
| 133 | Amniotic constriction ring (HP:0009775) | 1.79978298 |
| 134 | Abnormality of placental membranes (HP:0011409) | 1.79978298 |
| 135 | Myokymia (HP:0002411) | 1.79908137 |
| 136 | Leukodystrophy (HP:0002415) | 1.79611098 |
| 137 | Absent thumb (HP:0009777) | 1.79599380 |
| 138 | Pendular nystagmus (HP:0012043) | 1.78699284 |
| 139 | Abnormality of the ileum (HP:0001549) | 1.76778008 |
| 140 | Muscle fiber atrophy (HP:0100295) | 1.75997464 |
| 141 | Abnormality of the renal cortex (HP:0011035) | 1.73239005 |
| 142 | Hypothermia (HP:0002045) | 1.72387588 |
| 143 | Male pseudohermaphroditism (HP:0000037) | 1.71827911 |
| 144 | Abnormality of chromosome stability (HP:0003220) | 1.71174287 |
| 145 | Blindness (HP:0000618) | 1.69770589 |
| 146 | Pancytopenia (HP:0001876) | 1.69010349 |
| 147 | Furrowed tongue (HP:0000221) | 1.68594200 |
| 148 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.68473844 |
| 149 | Hyperphosphaturia (HP:0003109) | 1.67328440 |
| 150 | Septo-optic dysplasia (HP:0100842) | 1.65636138 |
| 151 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.65061641 |
| 152 | Congenital primary aphakia (HP:0007707) | 1.63939040 |
| 153 | Cystic liver disease (HP:0006706) | 1.62683908 |
| 154 | Abolished electroretinogram (ERG) (HP:0000550) | 1.61663090 |
| 155 | Gait imbalance (HP:0002141) | 1.60883325 |
| 156 | Small hand (HP:0200055) | 1.59714442 |
| 157 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.59022572 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.76811346 |
| 2 | WEE1 | 4.12401297 |
| 3 | FRK | 3.48529484 |
| 4 | PNCK | 3.44575004 |
| 5 | VRK2 | 3.42032689 |
| 6 | TSSK6 | 3.38847490 |
| 7 | STK16 | 3.02193907 |
| 8 | EIF2AK1 | 2.91713656 |
| 9 | AKT3 | 2.71200080 |
| 10 | PLK4 | 2.64971866 |
| 11 | SRPK1 | 2.53383814 |
| 12 | NME2 | 2.01688411 |
| 13 | PLK3 | 2.01544393 |
| 14 | EIF2AK3 | 1.96612564 |
| 15 | NME1 | 1.89797248 |
| 16 | ARAF | 1.88804290 |
| 17 | CASK | 1.76047653 |
| 18 | BRSK2 | 1.73282563 |
| 19 | CCNB1 | 1.72054302 |
| 20 | MKNK2 | 1.70961862 |
| 21 | VRK1 | 1.61824426 |
| 22 | MARK1 | 1.57061743 |
| 23 | GRK1 | 1.47953694 |
| 24 | MKNK1 | 1.46508195 |
| 25 | BRAF | 1.36897503 |
| 26 | INSRR | 1.36439607 |
| 27 | EPHA2 | 1.36096521 |
| 28 | TNIK | 1.35702821 |
| 29 | BRSK1 | 1.33843553 |
| 30 | PLK1 | 1.33487896 |
| 31 | PDK4 | 1.31281463 |
| 32 | PDK3 | 1.31281463 |
| 33 | ZAK | 1.30805601 |
| 34 | PINK1 | 1.28539548 |
| 35 | ACVR1B | 1.25302169 |
| 36 | TRIM28 | 1.21082666 |
| 37 | MAP4K2 | 1.20077891 |
| 38 | NEK1 | 1.19494266 |
| 39 | PDK2 | 1.18268733 |
| 40 | DYRK2 | 1.15965908 |
| 41 | PLK2 | 1.12265311 |
| 42 | TAF1 | 1.12114447 |
| 43 | TTK | 1.11934291 |
| 44 | MAP3K12 | 1.08742654 |
| 45 | PIM2 | 1.07070038 |
| 46 | MST4 | 1.05301135 |
| 47 | AURKA | 1.04909621 |
| 48 | LATS2 | 1.03591417 |
| 49 | OXSR1 | 1.01812305 |
| 50 | BCR | 0.98724295 |
| 51 | MAP2K7 | 0.97888488 |
| 52 | CDK19 | 0.97715223 |
| 53 | TESK2 | 0.96724263 |
| 54 | TAOK3 | 0.96124393 |
| 55 | EPHA4 | 0.93466641 |
| 56 | PBK | 0.90307046 |
| 57 | IRAK3 | 0.87944575 |
| 58 | WNK4 | 0.87335383 |
| 59 | CSNK1G3 | 0.87329320 |
| 60 | TGFBR1 | 0.85212966 |
| 61 | DYRK3 | 0.85200595 |
| 62 | EIF2AK2 | 0.84573142 |
| 63 | CHEK2 | 0.83278290 |
| 64 | LIMK1 | 0.80787185 |
| 65 | GRK5 | 0.79763934 |
| 66 | STK38L | 0.79745811 |
| 67 | MUSK | 0.77534852 |
| 68 | NEK6 | 0.75370049 |
| 69 | PRKCG | 0.74965931 |
| 70 | STK39 | 0.74155874 |
| 71 | PHKG1 | 0.73637926 |
| 72 | PHKG2 | 0.73637926 |
| 73 | NEK2 | 0.72432853 |
| 74 | ADRBK1 | 0.67586588 |
| 75 | ERBB4 | 0.66886740 |
| 76 | BMPR2 | 0.66609681 |
| 77 | AURKB | 0.66265131 |
| 78 | PRKCI | 0.64089195 |
| 79 | MYLK | 0.62786227 |
| 80 | CDK8 | 0.62466902 |
| 81 | BCKDK | 0.61148131 |
| 82 | CSNK1G2 | 0.59860283 |
| 83 | OBSCN | 0.59747073 |
| 84 | CAMK2B | 0.59266578 |
| 85 | RPS6KA5 | 0.58052243 |
| 86 | WNK3 | 0.55982190 |
| 87 | CSNK1G1 | 0.55262087 |
| 88 | CAMKK2 | 0.54963181 |
| 89 | ATR | 0.54599556 |
| 90 | NTRK3 | 0.54413791 |
| 91 | CSNK2A1 | 0.53587170 |
| 92 | MAPK13 | 0.53317770 |
| 93 | BMPR1B | 0.53030293 |
| 94 | ABL2 | 0.52734978 |
| 95 | STK3 | 0.51246203 |
| 96 | CDK3 | 0.50805571 |
| 97 | PAK1 | 0.50639075 |
| 98 | PRKCE | 0.49330599 |
| 99 | CSNK2A2 | 0.48310793 |
| 100 | MAPKAPK5 | 0.46948888 |
| 101 | ERBB3 | 0.46945256 |
| 102 | CDC7 | 0.45588502 |
| 103 | STK24 | 0.44404641 |
| 104 | MAP3K9 | 0.43958362 |
| 105 | RAF1 | 0.42921315 |
| 106 | CDK14 | 0.42474708 |
| 107 | CSNK1A1L | 0.42437290 |
| 108 | GRK7 | 0.40057508 |
| 109 | ILK | 0.39622159 |
| 110 | CSNK1E | 0.39207837 |
| 111 | MAP3K4 | 0.38791945 |
| 112 | CAMK2G | 0.37898068 |
| 113 | ADRBK2 | 0.37374496 |
| 114 | ATM | 0.37077569 |
| 115 | TLK1 | 0.37066917 |
| 116 | CHEK1 | 0.36847370 |
| 117 | CDK18 | 0.36355583 |
| 118 | RIPK4 | 0.34138479 |
| 119 | CDK15 | 0.33975651 |
| 120 | CAMK2A | 0.32537124 |
| 121 | CSNK1A1 | 0.32474295 |
| 122 | PKN1 | 0.32303363 |
| 123 | CDK11A | 0.32024383 |
| 124 | STK4 | 0.31886518 |
| 125 | PIK3CG | 0.31129143 |
| 126 | IKBKB | 0.30889588 |
| 127 | MINK1 | 0.30867664 |
| 128 | PRKACA | 0.30637686 |
| 129 | NUAK1 | 0.30361410 |
| 130 | CAMK2D | 0.29492145 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.28411587 |
| 2 | RNA polymerase_Homo sapiens_hsa03020 | 5.12570428 |
| 3 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 4.42750248 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.68648196 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 3.19086945 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.03562035 |
| 7 | RNA transport_Homo sapiens_hsa03013 | 2.56986531 |
| 8 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.54006025 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.51977223 |
| 10 | Basal transcription factors_Homo sapiens_hsa03022 | 2.38372419 |
| 11 | Spliceosome_Homo sapiens_hsa03040 | 2.29943332 |
| 12 | Regulation of autophagy_Homo sapiens_hsa04140 | 2.23673160 |
| 13 | Huntingtons disease_Homo sapiens_hsa05016 | 2.19219007 |
| 14 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.05437736 |
| 15 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.91167203 |
| 16 | DNA replication_Homo sapiens_hsa03030 | 1.88600173 |
| 17 | Homologous recombination_Homo sapiens_hsa03440 | 1.86049903 |
| 18 | Purine metabolism_Homo sapiens_hsa00230 | 1.79395671 |
| 19 | Alzheimers disease_Homo sapiens_hsa05010 | 1.71757373 |
| 20 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.71544557 |
| 21 | Cell cycle_Homo sapiens_hsa04110 | 1.65469540 |
| 22 | Mismatch repair_Homo sapiens_hsa03430 | 1.60555392 |
| 23 | Protein export_Homo sapiens_hsa03060 | 1.58101535 |
| 24 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.43578028 |
| 25 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.35368079 |
| 26 | RNA degradation_Homo sapiens_hsa03018 | 1.31919058 |
| 27 | Nicotine addiction_Homo sapiens_hsa05033 | 1.29710129 |
| 28 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.20822428 |
| 29 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.20248875 |
| 30 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.11265993 |
| 31 | Base excision repair_Homo sapiens_hsa03410 | 1.09867974 |
| 32 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.08861578 |
| 33 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.07694481 |
| 34 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.06368050 |
| 35 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.02606025 |
| 36 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.99212781 |
| 37 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.98345677 |
| 38 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.94489962 |
| 39 | Sulfur relay system_Homo sapiens_hsa04122 | 0.94149121 |
| 40 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.93751428 |
| 41 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.93340146 |
| 42 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.92947869 |
| 43 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.92654389 |
| 44 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.91306418 |
| 45 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.89149063 |
| 46 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.89104495 |
| 47 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.87480884 |
| 48 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.86288903 |
| 49 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.86171564 |
| 50 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.83096451 |
| 51 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.83034248 |
| 52 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.78130468 |
| 53 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.77885531 |
| 54 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.75975208 |
| 55 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.74089560 |
| 56 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.70923684 |
| 57 | Phototransduction_Homo sapiens_hsa04744 | 0.70771437 |
| 58 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.70609893 |
| 59 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.69633621 |
| 60 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.69536627 |
| 61 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.68698577 |
| 62 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.65716660 |
| 63 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.65579458 |
| 64 | Metabolic pathways_Homo sapiens_hsa01100 | 0.65524942 |
| 65 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.64048370 |
| 66 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.63863955 |
| 67 | Peroxisome_Homo sapiens_hsa04146 | 0.63047056 |
| 68 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.62597378 |
| 69 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.59934205 |
| 70 | * Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.59768230 |
| 71 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.59194372 |
| 72 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.58707623 |
| 73 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.56517741 |
| 74 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.55691013 |
| 75 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.54661357 |
| 76 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.54535269 |
| 77 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.52427469 |
| 78 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.52287362 |
| 79 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.51915546 |
| 80 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.51667361 |
| 81 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.51462359 |
| 82 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.51400262 |
| 83 | Retinol metabolism_Homo sapiens_hsa00830 | 0.48975949 |
| 84 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.48021074 |
| 85 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.47242943 |
| 86 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.46602182 |
| 87 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.46308871 |
| 88 | Circadian rhythm_Homo sapiens_hsa04710 | 0.45915462 |
| 89 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.45104645 |
| 90 | GABAergic synapse_Homo sapiens_hsa04727 | 0.42070897 |
| 91 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.41130921 |
| 92 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.40105143 |
| 93 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.39347875 |
| 94 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.37592535 |
| 95 | Taste transduction_Homo sapiens_hsa04742 | 0.35840914 |
| 96 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.33715128 |
| 97 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.30875813 |
| 98 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.30422820 |
| 99 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.29974300 |
| 100 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.28271805 |
| 101 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.25725624 |
| 102 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.25655577 |
| 103 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.25590431 |
| 104 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.24655030 |
| 105 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.24207172 |
| 106 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.23431941 |
| 107 | Long-term potentiation_Homo sapiens_hsa04720 | 0.22669601 |
| 108 | Phagosome_Homo sapiens_hsa04145 | 0.22469414 |
| 109 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.22357073 |
| 110 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.19793003 |
| 111 | Morphine addiction_Homo sapiens_hsa05032 | 0.18906884 |
| 112 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.18104583 |
| 113 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.17778234 |
| 114 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.16131296 |
| 115 | Long-term depression_Homo sapiens_hsa04730 | 0.16068753 |
| 116 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.15950883 |
| 117 | Mineral absorption_Homo sapiens_hsa04978 | 0.14121942 |
| 118 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.13732252 |
| 119 | Carbon metabolism_Homo sapiens_hsa01200 | 0.11731865 |
| 120 | Circadian entrainment_Homo sapiens_hsa04713 | 0.10445590 |
| 121 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.08758040 |
| 122 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.08118317 |
| 123 | Alcoholism_Homo sapiens_hsa05034 | 0.03947103 |
| 124 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.03692188 |
| 125 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.02234694 |
| 126 | Olfactory transduction_Homo sapiens_hsa04740 | 0.01586204 |
| 127 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.01542085 |
| 128 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.00956699 |
| 129 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.00179254 |

