TCEB1P19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1N-acetylneuraminate metabolic process (GO:0006054)8.41390598
2protoporphyrinogen IX metabolic process (GO:0046501)8.40311941
3positive regulation of histone deacetylation (GO:0031065)8.14971697
4centriole replication (GO:0007099)7.58130618
5regulation of MHC class II biosynthetic process (GO:0045346)7.26821555
6positive regulation of protein deacetylation (GO:0090312)7.24525060
7positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)7.03728952
8microglial cell activation (GO:0001774)6.76116654
9purine deoxyribonucleotide catabolic process (GO:0009155)6.19152659
10amino sugar catabolic process (GO:0046348)5.84537637
11neutrophil mediated immunity (GO:0002446)5.81985515
12negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)5.69076302
13N-acetylglucosamine metabolic process (GO:0006044)5.65415502
14insulin-like growth factor receptor signaling pathway (GO:0048009)5.59351190
15killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.14135236
16disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.14135236
17reactive oxygen species biosynthetic process (GO:1903409)5.09202250
18base-excision repair, AP site formation (GO:0006285)5.04590323
19centriole assembly (GO:0098534)5.04433382
20negative regulation of phagocytosis (GO:0050765)4.98605544
21modulation of growth of symbiont involved in interaction with host (GO:0044144)4.91453284
22regulation of growth of symbiont in host (GO:0044126)4.91453284
23negative regulation of growth of symbiont in host (GO:0044130)4.91453284
24negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.91453284
25regulation of chemokine biosynthetic process (GO:0045073)4.89127744
26positive regulation of chemokine biosynthetic process (GO:0045080)4.85763905
27response to folic acid (GO:0051593)4.75558614
28regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.52169701
29regulation of histone deacetylation (GO:0031063)4.48210164
30thalamus development (GO:0021794)4.44900292
31myeloid leukocyte mediated immunity (GO:0002444)4.41709310
32cytokinetic process (GO:0032506)4.02410489
33negative regulation of interleukin-2 production (GO:0032703)3.98294012
34macrophage activation (GO:0042116)3.97981800
35respiratory burst (GO:0045730)3.95096301
36purine deoxyribonucleotide metabolic process (GO:0009151)3.90030917
37regulation of protein deacetylation (GO:0090311)3.73572241
38regulation of fatty acid transport (GO:2000191)3.69701681
39prostate gland growth (GO:0060736)3.65481080
40angiotensin maturation (GO:0002003)3.54569602
41glucosamine-containing compound metabolic process (GO:1901071)3.48313493
42positive regulation by symbiont of host defense response (GO:0052509)3.44968804
43modulation by symbiont of host defense response (GO:0052031)3.44968804
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.44968804
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.44968804
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.44968804
47modulation by symbiont of host immune response (GO:0052553)3.44968804
48defense response to fungus (GO:0050832)3.42175604
49positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.31165621
50early endosome to late endosome transport (GO:0045022)3.31065738
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30359954
52ventricular system development (GO:0021591)3.30118110
53CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.27875227
54cellular response to ethanol (GO:0071361)3.27672834
55regulation of thymocyte apoptotic process (GO:0070243)3.26502727
56macrophage chemotaxis (GO:0048246)3.23944257
57regulation of protein import into nucleus, translocation (GO:0033158)3.23531134
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22226584
59signal complex assembly (GO:0007172)3.22212714
60DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.20986863
61positive regulation of interleukin-1 beta production (GO:0032731)3.10276488
62regulation of erythrocyte differentiation (GO:0045646)3.08560782
63cellular response to cadmium ion (GO:0071276)3.04710707
64heme biosynthetic process (GO:0006783)3.00160779
65response to host immune response (GO:0052572)2.99967707
66response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.99967707
67positive regulation of interleukin-1 production (GO:0032732)2.99741095
68induction of positive chemotaxis (GO:0050930)2.97098232
69positive regulation of gamma-delta T cell activation (GO:0046645)2.96070464
70response to fungus (GO:0009620)2.93164046
71negative regulation of cell killing (GO:0031342)2.92630173
72negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.92630173
73positive regulation of erythrocyte differentiation (GO:0045648)2.88558236
74regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.85677269
75regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.85677269
76DNA damage response, signal transduction resulting in transcription (GO:0042772)2.84175098
77regulation of glycolytic process (GO:0006110)2.82228668
78CD4-positive, alpha-beta T cell activation (GO:0035710)2.82133757
79interferon-gamma production (GO:0032609)2.80276473
80positive regulation of histone H3-K4 methylation (GO:0051571)2.79434588
81response to misfolded protein (GO:0051788)2.71909720
82positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68681664
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67861657
84response to host (GO:0075136)2.67861657
85response to host defenses (GO:0052200)2.67861657
86positive regulation of mast cell activation involved in immune response (GO:0033008)2.65053507
87positive regulation of mast cell degranulation (GO:0043306)2.65053507
88negative regulation of T cell mediated immunity (GO:0002710)2.58795637
89disruption of cells of other organism (GO:0044364)2.57410695
90killing of cells of other organism (GO:0031640)2.57410695
91porphyrin-containing compound biosynthetic process (GO:0006779)2.55336198
92interkinetic nuclear migration (GO:0022027)2.55036662
93somatic diversification of immune receptors (GO:0002200)2.53869573
94alpha-beta T cell differentiation (GO:0046632)2.52181847
95negative regulation of histone acetylation (GO:0035067)2.51992347
96positive regulation of mast cell activation (GO:0033005)2.51427139
97sodium-independent organic anion transport (GO:0043252)2.51085169
98phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.50274485
99cellular extravasation (GO:0045123)11.1655453
100protoporphyrinogen IX biosynthetic process (GO:0006782)10.4913913

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.70615116
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.75504735
3IKZF1_21737484_ChIP-ChIP_HCT116_Human3.63244490
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.08864205
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.91313780
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.78915395
7SCL_19346495_ChIP-Seq_HPC-7_Human2.65057855
8ER_23166858_ChIP-Seq_MCF-7_Human2.62952445
9GBX2_23144817_ChIP-Seq_PC3_Human2.23425297
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.14725462
11SALL1_21062744_ChIP-ChIP_HESCs_Human1.97283689
12LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.95662558
13POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91670778
14IRF1_19129219_ChIP-ChIP_H3396_Human1.88993627
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86372765
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84980623
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84963625
18VDR_24787735_ChIP-Seq_THP-1_Human1.79285707
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75899573
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72162706
21FUS_26573619_Chip-Seq_HEK293_Human1.65421482
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62944181
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.62727345
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61079007
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60345840
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59347941
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.58900991
28ZNF274_21170338_ChIP-Seq_K562_Hela1.55948476
29RXR_22108803_ChIP-Seq_LS180_Human1.52402547
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51390325
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51126020
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46613489
33VDR_24763502_ChIP-Seq_THP-1_Human1.45552897
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42509336
35BCAT_22108803_ChIP-Seq_LS180_Human1.41545367
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39972464
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36386256
38RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34362555
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33014081
40STAT3_23295773_ChIP-Seq_U87_Human1.32291916
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.31316684
42EZH2_22144423_ChIP-Seq_EOC_Human1.29743195
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28441026
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28441026
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27922516
46CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27625513
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27522872
48FLI1_21867929_ChIP-Seq_TH2_Mouse1.27163302
49RUNX_20019798_ChIP-Seq_JUKART_Human1.26196132
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25952054
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25497539
52EWS_26573619_Chip-Seq_HEK293_Human1.24891661
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24418910
54SPI1_23127762_ChIP-Seq_K562_Human1.22603990
55GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21971069
56TCF4_23295773_ChIP-Seq_U87_Human1.21167413
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20722971
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20683769
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19030493
60SPI1_23547873_ChIP-Seq_NB4_Human1.16660434
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16083983
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15743205
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14540475
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14517552
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13727074
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10896291
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09294367
68GATA3_27048872_Chip-Seq_THYMUS_Human1.08522844
69MYB_26560356_Chip-Seq_TH2_Human1.07341520
70SMRT_27268052_Chip-Seq_Bcells_Human1.06903419
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06585894
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04039008
73NANOG_19829295_ChIP-Seq_ESCs_Human1.03111201
74SOX2_19829295_ChIP-Seq_ESCs_Human1.03111201
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.02139991
76GATA3_26560356_Chip-Seq_TH2_Human1.02012240
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99628756
78MYB_26560356_Chip-Seq_TH1_Human0.98743804
79TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98552844
80AR_20517297_ChIP-Seq_VCAP_Human0.98055313
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95385329
82PRDM14_20953172_ChIP-Seq_ESCs_Human0.93307678
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92702063
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92670245
85SMAD4_21799915_ChIP-Seq_A2780_Human0.92567968
86EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91908308
87NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90725725
88ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90436482
89P300_19829295_ChIP-Seq_ESCs_Human0.90413188
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89303373
91E2F1_18555785_Chip-Seq_ESCs_Mouse0.88926160
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88773614
93TAF15_26573619_Chip-Seq_HEK293_Human0.88671446
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86673292
95RUNX2_22187159_ChIP-Seq_PCA_Human0.85688288
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85522118
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.84961380
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.84336279
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84336279
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84323031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract7.46360312
2MP0003252_abnormal_bile_duct4.32140965
3MP0008961_abnormal_basal_metabolism4.29257752
4MP0008057_abnormal_DNA_replication4.05731114
5MP0005670_abnormal_white_adipose3.77553292
6MP0008058_abnormal_DNA_repair3.64244010
7MP0004043_abnormal_pH_regulation3.49216069
8MP0005365_abnormal_bile_salt2.76227908
9MP0005085_abnormal_gallbladder_physiolo2.58692613
10MP0005451_abnormal_body_composition2.54797798
11MP0002132_abnormal_respiratory_system2.48005367
12MP0000569_abnormal_digit_pigmentation2.46004852
13MP0001835_abnormal_antigen_presentation2.11791205
14MP0000003_abnormal_adipose_tissue2.05921250
15MP0000516_abnormal_urinary_system2.04191550
16MP0005367_renal/urinary_system_phenotyp2.04191550
17MP0003724_increased_susceptibility_to1.87639134
18MP0002419_abnormal_innate_immunity1.79522538
19MP0004742_abnormal_vestibular_system1.71645405
20MP0009278_abnormal_bone_marrow1.63433413
21MP0003303_peritoneal_inflammation1.57090382
22MP0001800_abnormal_humoral_immune1.55808144
23MP0004885_abnormal_endolymph1.52766817
24MP0003121_genomic_imprinting1.47419107
25MP0008877_abnormal_DNA_methylation1.46539235
26MP0009115_abnormal_fat_cell1.43595009
27MP0005375_adipose_tissue_phenotype1.42783289
28MP0002420_abnormal_adaptive_immunity1.41880943
29MP0005310_abnormal_salivary_gland1.41609064
30MP0001819_abnormal_immune_cell1.38938046
31MP0002452_abnormal_antigen_presenting1.34288991
32MP0005397_hematopoietic_system_phenotyp1.31493430
33MP0001545_abnormal_hematopoietic_system1.31493430
34MP0003436_decreased_susceptibility_to1.31227153
35MP0003195_calcinosis1.29177040
36MP0000685_abnormal_immune_system1.27077148
37MP0005025_abnormal_response_to1.25582891
38MP0010329_abnormal_lipoprotein_level1.19803024
39MP0002723_abnormal_immune_serum1.19317128
40MP0003123_paternal_imprinting1.19176859
41MP0003787_abnormal_imprinting1.17953440
42MP0005000_abnormal_immune_tolerance1.17166718
43MP0009785_altered_susceptibility_to1.17032956
44MP0004142_abnormal_muscle_tone1.15441106
45MP0000015_abnormal_ear_pigmentation1.14373977
46MP0002166_altered_tumor_susceptibility1.13088580
47MP0002398_abnormal_bone_marrow1.12275404
48MP0003221_abnormal_cardiomyocyte_apopto1.07087015
49MP0001501_abnormal_sleep_pattern1.05709283
50MP0005671_abnormal_response_to1.05672328
51MP0001502_abnormal_circadian_rhythm1.05294888
52MP0005387_immune_system_phenotype1.03441580
53MP0001790_abnormal_immune_system1.03441580
54MP0005464_abnormal_platelet_physiology1.03381916
55MP0000703_abnormal_thymus_morphology1.02424240
56MP0000716_abnormal_immune_system1.00754133
57MP0005266_abnormal_metabolism1.00558711
58MP0005174_abnormal_tail_pigmentation1.00104946
59MP0008872_abnormal_physiological_respon0.99435138
60MP0002396_abnormal_hematopoietic_system0.97877292
61MP0002127_abnormal_cardiovascular_syste0.96395347
62MP0005220_abnormal_exocrine_pancreas0.92511393
63MP0003172_abnormal_lysosome_physiology0.90675523
64MP0002722_abnormal_immune_system0.89721212
65MP0002405_respiratory_system_inflammati0.89422061
66MP0000689_abnormal_spleen_morphology0.87080392
67MP0004947_skin_inflammation0.84337367
68MP0002006_tumorigenesis0.84092728
69MP0001529_abnormal_vocalization0.83187536
70MP0000383_abnormal_hair_follicle0.83138022
71MP0002693_abnormal_pancreas_physiology0.82528618
72MP0003763_abnormal_thymus_physiology0.79601396
73MP0005164_abnormal_response_to0.79232855
74MP0002095_abnormal_skin_pigmentation0.78362141
75MP0005551_abnormal_eye_electrophysiolog0.74418180
76MP0008007_abnormal_cellular_replicative0.73436666
77MP0002429_abnormal_blood_cell0.72994205
78MP0001845_abnormal_inflammatory_respons0.72925812
79MP0002933_joint_inflammation0.72645170
80MP0001919_abnormal_reproductive_system0.72346082
81MP0002876_abnormal_thyroid_physiology0.72002271
82MP0003828_pulmonary_edema0.69144779
83MP0000465_gastrointestinal_hemorrhage0.66721662
84MP0002970_abnormal_white_adipose0.65376163
85MP0005334_abnormal_fat_pad0.65074536
86MP0005379_endocrine/exocrine_gland_phen0.64527881
87MP0010678_abnormal_skin_adnexa0.64021404
88MP0010307_abnormal_tumor_latency0.63318107
89MP0001270_distended_abdomen0.62874947
90MP0004808_abnormal_hematopoietic_stem0.61691615
91MP0003786_premature_aging0.60637872
92MP0003690_abnormal_glial_cell0.58527652
93MP0002163_abnormal_gland_morphology0.58503264
94MP0000955_abnormal_spinal_cord0.57461824
95MP0009643_abnormal_urine_homeostasis0.56563746
96MP0003567_abnormal_fetal_cardiomyocyte0.55832252
97MP0002928_abnormal_bile_duct0.55785823
98MP0008875_abnormal_xenobiotic_pharmacok0.55073700
99MP0005448_abnormal_energy_balance0.53538182
100MP0000427_abnormal_hair_cycle0.52081381

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)5.84802517
2Panhypogammaglobulinemia (HP:0003139)5.30133994
3Abnormality of B cell number (HP:0010975)5.27085942
4Thyroiditis (HP:0100646)5.24379685
5Severe combined immunodeficiency (HP:0004430)5.17785026
6Hypoproteinemia (HP:0003075)4.52359240
7Hypoplasia of the thymus (HP:0000778)4.46621549
8Combined immunodeficiency (HP:0005387)4.00601100
9T lymphocytopenia (HP:0005403)3.88685911
10Abnormality of the prostate (HP:0008775)3.78801998
11Eosinophilia (HP:0001880)3.54551026
12Papillary thyroid carcinoma (HP:0002895)3.42239743
13Abnormality of T cell number (HP:0011839)3.40449358
14Chest pain (HP:0100749)3.39966379
15Abnormality of eosinophils (HP:0001879)3.35326081
16Chronic obstructive pulmonary disease (HP:0006510)3.30902592
17Obstructive lung disease (HP:0006536)3.30902592
18Recurrent fungal infections (HP:0002841)3.29522601
19Granulocytopenia (HP:0001913)3.28293381
20Hypokalemic alkalosis (HP:0001949)3.23703287
21Meningitis (HP:0001287)3.19876410
22Cutaneous photosensitivity (HP:0000992)3.14497659
23Metabolic alkalosis (HP:0200114)3.12983190
24Generalized hyperpigmentation (HP:0007440)3.02938871
25Severe global developmental delay (HP:0011344)2.99677828
26Abnormality of chloride homeostasis (HP:0011422)2.94252482
27Protruding tongue (HP:0010808)2.94000361
28Myositis (HP:0100614)2.92501134
29Subacute progressive viral hepatitis (HP:0006572)2.92240773
30Recurrent bacterial skin infections (HP:0005406)2.86449192
31Hemoptysis (HP:0002105)2.82949180
32Failure to thrive in infancy (HP:0001531)2.77228196
33Neoplasm of the adrenal cortex (HP:0100641)2.69121578
34Adactyly (HP:0009776)2.63937390
35Leukocytosis (HP:0001974)2.59181641
36Febrile seizures (HP:0002373)2.58115447
37Thyroid carcinoma (HP:0002890)2.56662160
38Recurrent viral infections (HP:0004429)2.52523454
39Optic neuritis (HP:0100653)2.50333951
40Retrobulbar optic neuritis (HP:0100654)2.50333951
41Absent speech (HP:0001344)2.45675775
42Pulmonary infiltrates (HP:0002113)2.44079425
43Fair hair (HP:0002286)2.42975619
44Porencephaly (HP:0002132)2.40218801
45Sepsis (HP:0100806)2.37230671
46Gangrene (HP:0100758)2.36682940
47Recurrent abscess formation (HP:0002722)2.36321286
48Neonatal respiratory distress (HP:0002643)2.32350541
49Erythroderma (HP:0001019)2.31973029
50Abnormality of T cells (HP:0002843)2.29332155
51Viral hepatitis (HP:0006562)2.25787945
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.23551753
53Orchitis (HP:0100796)2.19876265
54Generalized hypopigmentation of hair (HP:0011358)2.19856415
55Abnormality of male internal genitalia (HP:0000022)2.19682118
56Medial flaring of the eyebrow (HP:0010747)2.14850350
57Ureteral obstruction (HP:0006000)2.12207460
58Episodic fever (HP:0001954)2.11983764
59Pulmonary embolism (HP:0002204)2.11063103
60Stomatitis (HP:0010280)2.09785772
61Abnormal ciliary motility (HP:0012262)2.09304642
62Prostate neoplasm (HP:0100787)2.05153352
63IgG deficiency (HP:0004315)2.01658063
64Arterial thrombosis (HP:0004420)2.00382695
65Hyperaldosteronism (HP:0000859)1.98104337
66Flat occiput (HP:0005469)1.97932754
67Ureteral stenosis (HP:0000071)1.97187985
68Prominent metopic ridge (HP:0005487)1.95537479
69Eczematoid dermatitis (HP:0000976)1.94427832
70Aplasia/Hypoplasia of the thymus (HP:0010515)1.89046995
71Vasculitis (HP:0002633)1.87968079
72Neonatal hypoglycemia (HP:0001998)1.87645348
73Renal cell carcinoma (HP:0005584)1.86830467
74Lissencephaly (HP:0001339)1.86665036
75Keratoconjunctivitis sicca (HP:0001097)1.86519626
76Excessive salivation (HP:0003781)1.84583557
77Hematochezia (HP:0002573)1.84374686
78Renal salt wasting (HP:0000127)1.84285901
79Pancreatic islet-cell hyperplasia (HP:0004510)1.83246438
80Attenuation of retinal blood vessels (HP:0007843)1.81609337
81Inappropriate behavior (HP:0000719)1.81448201
82Recurrent skin infections (HP:0001581)1.79799863
83Drooling (HP:0002307)1.79724889
84Abnormality of the pleura (HP:0002103)1.78438158
85Intestinal atresia (HP:0011100)1.78366040
86Widely spaced teeth (HP:0000687)1.78118353
87Abnormality of the metopic suture (HP:0005556)1.77477034
88Thrombophlebitis (HP:0004418)1.77400132
89Abnormality of the renal cortex (HP:0011035)1.76159955
90Hyperkalemia (HP:0002153)1.75464603
91Tubulointerstitial fibrosis (HP:0005576)1.73546791
92Broad-based gait (HP:0002136)1.73197688
93Keratoconjunctivitis (HP:0001096)1.71194274
94Progressive cerebellar ataxia (HP:0002073)1.71055244
95Skin rash (HP:0000988)1.70398900
96Abnormal rod and cone electroretinograms (HP:0008323)1.70061156
97Gastrointestinal infarctions (HP:0005244)1.69175075
98Recurrent gram-negative bacterial infections (HP:0005420)1.68559666
99Abnormality of chromosome stability (HP:0003220)1.68398790
100Gaze-evoked nystagmus (HP:0000640)1.68112502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB18.24328341
2NEK25.63051045
3TAF15.30456151
4CAMKK24.40697099
5CAMK1D3.46893937
6CAMK1G2.61368072
7ERN12.47524169
8FRK2.14795169
9SMG12.12587067
10CAMKK11.74971127
11MAP3K71.64547915
12TXK1.58428137
13NUAK11.45698124
14VRK21.40712695
15CHUK1.39257378
16FGFR31.37267748
17LRRK21.27425628
18WNK41.16564321
19MARK21.15000054
20SYK1.12937496
21CAMK11.11501584
22SGK21.04865075
23NTRK31.04555296
24EPHB11.04097160
25CSK1.01818099
26TAOK31.01695426
27ZAP701.00740573
28KSR20.97877765
29PRPF4B0.97557410
30MAP4K10.96008410
31WNK10.95570640
32TRIM280.92551948
33IKBKE0.88946092
34DYRK1A0.85514064
35MAPK130.82454128
36TNK20.80263464
37CAMK40.73754510
38RAF10.72957556
39HCK0.71318256
40BTK0.69063076
41TEC0.66217295
42MAP3K20.65665371
43HIPK20.63413383
44MATK0.63376681
45TESK20.61143005
46MAP2K30.61090437
47TYK20.59360865
48STK110.58250268
49NLK0.57625172
50SGK4940.57146329
51SGK2230.57146329
52ITK0.56713589
53SGK30.56040180
54NTRK20.55079750
55RIPK40.54203788
56IRAK40.53551988
57BLK0.53543492
58SGK10.52594509
59MAP3K40.52003559
60KIT0.51967077
61LYN0.51610798
62CLK10.51186565
63GRK50.50833572
64WNK30.50802383
65PRKAA20.49755060
66JAK20.48331086
67KSR10.48214599
68IRAK20.45061584
69LCK0.42231764
70MAPK40.40126468
71MAP3K60.40096841
72GRK60.39385297
73OXSR10.38883723
74PIK3CG0.37890638
75IRAK10.37311141
76YES10.36349724
77BRAF0.34536175
78RPS6KB20.34270888
79ERBB30.33385049
80AKT30.31282186
81JAK30.30417137
82EIF2AK20.29868323
83DYRK20.29528832
84RPS6KA40.29181409
85MKNK20.28129434
86CSNK1G10.27894166
87PAK30.26914635
88MAP2K40.26524521
89PASK0.25535890
90GRK70.24782038
91MAPKAPK50.23227455
92FES0.22950565
93PDGFRB0.22715769
94ERBB20.22474645
95RPS6KB10.22318294
96DYRK1B0.21939786
97FGFR20.20896754
98CDK90.20886929
99PDK10.20463014
100IKBKB0.20211920

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.12388279
2Primary immunodeficiency_Homo sapiens_hsa053402.61275558
3Renin-angiotensin system_Homo sapiens_hsa046142.52613750
4Caffeine metabolism_Homo sapiens_hsa002322.20184200
5Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.14456137
6Non-homologous end-joining_Homo sapiens_hsa034502.08290348
7Osteoclast differentiation_Homo sapiens_hsa043801.88702232
8B cell receptor signaling pathway_Homo sapiens_hsa046621.88541812
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.84684037
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.81231035
11Transcriptional misregulation in cancer_Homo sapiens_hsa052021.76922590
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.75058581
13FoxO signaling pathway_Homo sapiens_hsa040681.68999552
14T cell receptor signaling pathway_Homo sapiens_hsa046601.65799144
15Taste transduction_Homo sapiens_hsa047421.47638370
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39026968
17Hematopoietic cell lineage_Homo sapiens_hsa046401.37914697
18mTOR signaling pathway_Homo sapiens_hsa041501.37207032
19Acute myeloid leukemia_Homo sapiens_hsa052211.36103008
20Staphylococcus aureus infection_Homo sapiens_hsa051501.35938929
21ErbB signaling pathway_Homo sapiens_hsa040121.33610010
22Phototransduction_Homo sapiens_hsa047441.25822870
23Tuberculosis_Homo sapiens_hsa051521.24505625
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20871587
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20447794
26Phagosome_Homo sapiens_hsa041451.17869884
27Non-small cell lung cancer_Homo sapiens_hsa052231.15995759
28Propanoate metabolism_Homo sapiens_hsa006401.13718347
29Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09970004
30Basal transcription factors_Homo sapiens_hsa030221.09417711
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08901362
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08632868
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06986075
34Prolactin signaling pathway_Homo sapiens_hsa049171.05622778
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05197050
36Glutamatergic synapse_Homo sapiens_hsa047241.04004061
37Leishmaniasis_Homo sapiens_hsa051401.02274405
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.01805131
39Inositol phosphate metabolism_Homo sapiens_hsa005620.98763077
40Ether lipid metabolism_Homo sapiens_hsa005650.97977784
41Platelet activation_Homo sapiens_hsa046110.97578565
42Chemokine signaling pathway_Homo sapiens_hsa040620.97056115
43Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95287805
44Axon guidance_Homo sapiens_hsa043600.93750067
45Fanconi anemia pathway_Homo sapiens_hsa034600.92914715
46Linoleic acid metabolism_Homo sapiens_hsa005910.91284842
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90637523
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89880870
49Long-term depression_Homo sapiens_hsa047300.85850230
50Renal cell carcinoma_Homo sapiens_hsa052110.85668978
51Chronic myeloid leukemia_Homo sapiens_hsa052200.84185300
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83612356
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82276727
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81362532
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80888411
56Lysosome_Homo sapiens_hsa041420.78268990
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78150652
58Glioma_Homo sapiens_hsa052140.78043652
59Thyroid cancer_Homo sapiens_hsa052160.77066992
60Histidine metabolism_Homo sapiens_hsa003400.76425812
61Morphine addiction_Homo sapiens_hsa050320.75638801
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.74508833
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74438873
64Ovarian steroidogenesis_Homo sapiens_hsa049130.73446512
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.72184988
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71676985
67Regulation of autophagy_Homo sapiens_hsa041400.69465037
68Endometrial cancer_Homo sapiens_hsa052130.68988323
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68888852
70Olfactory transduction_Homo sapiens_hsa047400.67021731
71Viral carcinogenesis_Homo sapiens_hsa052030.65364112
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63838391
73Nitrogen metabolism_Homo sapiens_hsa009100.62027635
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60132443
75Long-term potentiation_Homo sapiens_hsa047200.60091210
76Nicotine addiction_Homo sapiens_hsa050330.59642496
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57992413
78Cholinergic synapse_Homo sapiens_hsa047250.57533431
79Oxytocin signaling pathway_Homo sapiens_hsa049210.56737931
80Type II diabetes mellitus_Homo sapiens_hsa049300.56079453
81Starch and sucrose metabolism_Homo sapiens_hsa005000.55883007
82African trypanosomiasis_Homo sapiens_hsa051430.50784421
83Legionellosis_Homo sapiens_hsa051340.49509040
84Hepatitis B_Homo sapiens_hsa051610.49498803
85Pyruvate metabolism_Homo sapiens_hsa006200.49031627
86MAPK signaling pathway_Homo sapiens_hsa040100.48335330
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.47343354
88Measles_Homo sapiens_hsa051620.47100077
89Dorso-ventral axis formation_Homo sapiens_hsa043200.47056896
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.46575165
91Melanoma_Homo sapiens_hsa052180.45235586
92Rheumatoid arthritis_Homo sapiens_hsa053230.44496433
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43266620
94Homologous recombination_Homo sapiens_hsa034400.42666268
95GnRH signaling pathway_Homo sapiens_hsa049120.41902551
96Colorectal cancer_Homo sapiens_hsa052100.41765643
97Malaria_Homo sapiens_hsa051440.41522529
98Choline metabolism in cancer_Homo sapiens_hsa052310.41423464
99ABC transporters_Homo sapiens_hsa020100.40621656
100Serotonergic synapse_Homo sapiens_hsa047260.40208421

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