TCEB1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.39863976
2DNA deamination (GO:0045006)6.92694925
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.60288025
4ATP synthesis coupled proton transport (GO:0015986)6.60288025
5cytidine deamination (GO:0009972)6.08262850
6cytidine metabolic process (GO:0046087)6.08262850
7cytidine catabolic process (GO:0006216)6.08262850
8viral transcription (GO:0019083)5.68917905
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.59604786
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.55233805
11ribosomal small subunit biogenesis (GO:0042274)5.54135426
12pyrimidine ribonucleoside catabolic process (GO:0046133)5.46800109
13translational termination (GO:0006415)5.46305486
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.39292097
15respiratory electron transport chain (GO:0022904)5.38855153
16protein targeting to ER (GO:0045047)5.33674958
17cotranslational protein targeting to membrane (GO:0006613)5.33361679
18electron transport chain (GO:0022900)5.29782752
19protein localization to endoplasmic reticulum (GO:0070972)5.10401254
20establishment of protein localization to endoplasmic reticulum (GO:0072599)5.06369464
21establishment of protein localization to mitochondrial membrane (GO:0090151)4.93419610
22translational elongation (GO:0006414)4.73376223
23maturation of SSU-rRNA (GO:0030490)4.71797684
24ribosomal small subunit assembly (GO:0000028)4.51202653
25sequestering of actin monomers (GO:0042989)4.14767607
26chaperone-mediated protein transport (GO:0072321)4.10521073
27cellular protein complex disassembly (GO:0043624)4.03992617
28viral life cycle (GO:0019058)4.03323190
29protein complex biogenesis (GO:0070271)4.01442348
30iron-sulfur cluster assembly (GO:0016226)3.87178449
31metallo-sulfur cluster assembly (GO:0031163)3.87178449
32ATP biosynthetic process (GO:0006754)3.83537219
33protein neddylation (GO:0045116)3.78178023
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.76312499
35hydrogen ion transmembrane transport (GO:1902600)3.69976679
36mitochondrial respiratory chain complex assembly (GO:0033108)3.69004072
37purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.63805700
38protein targeting to membrane (GO:0006612)3.60281892
39nonmotile primary cilium assembly (GO:0035058)3.59399933
40translational initiation (GO:0006413)3.59256397
41purine nucleoside triphosphate biosynthetic process (GO:0009145)3.59127043
42oxidative phosphorylation (GO:0006119)3.58623415
43translation (GO:0006412)3.57025938
44proton transport (GO:0015992)3.44580928
45signal peptide processing (GO:0006465)3.40513742
46ncRNA 3-end processing (GO:0043628)3.36895631
47hydrogen transport (GO:0006818)3.35536604
48purine deoxyribonucleotide catabolic process (GO:0009155)3.34040467
49behavioral response to nicotine (GO:0035095)3.29125362
50negative regulation of T cell differentiation in thymus (GO:0033085)3.26984775
51protein complex disassembly (GO:0043241)3.19071728
52cytochrome complex assembly (GO:0017004)3.16423473
53ribonucleoside triphosphate biosynthetic process (GO:0009201)3.10403635
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07378187
55respiratory chain complex IV assembly (GO:0008535)3.07218675
56macromolecular complex disassembly (GO:0032984)3.06679692
57production of molecular mediator involved in inflammatory response (GO:0002532)3.06639952
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05988009
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.05988009
60NADH dehydrogenase complex assembly (GO:0010257)3.05988009
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.04470150
62termination of RNA polymerase III transcription (GO:0006386)3.04470150
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01370804
64GTP biosynthetic process (GO:0006183)3.01322556
65positive regulation of mitochondrial fission (GO:0090141)3.00294654
66substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.98451580
67substrate-independent telencephalic tangential migration (GO:0021826)2.98451580
68base-excision repair, AP site formation (GO:0006285)2.90269132
69anterograde synaptic vesicle transport (GO:0048490)2.88332615
70protein-cofactor linkage (GO:0018065)2.81832539
71platelet dense granule organization (GO:0060155)2.81299504
72nuclear-transcribed mRNA catabolic process (GO:0000956)2.76667265
73negative regulation by host of viral transcription (GO:0043922)2.75690215
74pyrimidine ribonucleoside metabolic process (GO:0046131)2.73409568
75protein targeting to mitochondrion (GO:0006626)2.71507345
76response to pheromone (GO:0019236)2.70909053
77nucleoside triphosphate biosynthetic process (GO:0009142)2.69189293
78organelle disassembly (GO:1903008)2.67839884
79pyrimidine nucleoside catabolic process (GO:0046135)2.64361658
80eosinophil chemotaxis (GO:0048245)2.61930009
81establishment of protein localization to mitochondrion (GO:0072655)2.61510361
82mRNA catabolic process (GO:0006402)2.59219906
83cell wall macromolecule metabolic process (GO:0044036)2.57672544
84regulation of cilium movement (GO:0003352)2.57034452
85positive regulation of defense response to virus by host (GO:0002230)2.56376098
86protein localization to mitochondrion (GO:0070585)2.54056106
87epithelial cilium movement (GO:0003351)2.53920114
88histone mRNA metabolic process (GO:0008334)2.53222159
89negative regulation of T cell receptor signaling pathway (GO:0050860)2.51560010
90establishment of protein localization to membrane (GO:0090150)2.48508505
91positive regulation of calcium-mediated signaling (GO:0050850)2.48031787
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.45292402
93protein polyglutamylation (GO:0018095)2.44808969
94regulation of cellular amino acid metabolic process (GO:0006521)2.44018801
95indolalkylamine metabolic process (GO:0006586)2.41764850
96Arp2/3 complex-mediated actin nucleation (GO:0034314)2.41667625
97GPI anchor metabolic process (GO:0006505)2.38731623
98eosinophil migration (GO:0072677)2.38309548
99cellular component biogenesis (GO:0044085)2.37894011
100regulation of rhodopsin mediated signaling pathway (GO:0022400)2.37186569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.97827526
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.55448008
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.70429319
4EZH2_22144423_ChIP-Seq_EOC_Human4.20811332
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65788254
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.64815332
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.57336787
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.32391839
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.90696731
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74833696
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49752029
12VDR_22108803_ChIP-Seq_LS180_Human2.21720417
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12446831
14ZNF274_21170338_ChIP-Seq_K562_Hela2.01133441
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.00657368
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97874206
17VDR_23849224_ChIP-Seq_CD4+_Human1.91688935
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90682832
19ELK1_19687146_ChIP-ChIP_HELA_Human1.87279479
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77724354
21MYC_18940864_ChIP-ChIP_HL60_Human1.74302034
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73912862
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71354597
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.71276280
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59563706
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56761133
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52910326
28MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43212224
29P300_19829295_ChIP-Seq_ESCs_Human1.38674732
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.36285163
31TP53_22573176_ChIP-Seq_HFKS_Human1.34310459
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33924052
33FOXP3_21729870_ChIP-Seq_TREG_Human1.33780809
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31486014
35IGF1R_20145208_ChIP-Seq_DFB_Human1.29293709
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28685579
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.26417176
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.24082519
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24075990
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23637680
41IRF1_19129219_ChIP-ChIP_H3396_Human1.21697805
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.21526799
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20083396
44NANOG_19829295_ChIP-Seq_ESCs_Human1.19145939
45SOX2_19829295_ChIP-Seq_ESCs_Human1.19145939
46EWS_26573619_Chip-Seq_HEK293_Human1.18606210
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13145909
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13113479
49NCOR_22424771_ChIP-Seq_293T_Human1.12181367
50TTF2_22483619_ChIP-Seq_HELA_Human1.11348471
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.10407953
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09591930
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09190338
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08433410
55AR_20517297_ChIP-Seq_VCAP_Human1.07916443
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05461363
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02139125
58TAF15_26573619_Chip-Seq_HEK293_Human1.01658262
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00296459
60RNF2_27304074_Chip-Seq_NSC_Mouse0.99670777
61EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98257737
62HTT_18923047_ChIP-ChIP_STHdh_Human0.97537047
63NANOG_20526341_ChIP-Seq_ESCs_Human0.96704075
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95870710
65FUS_26573619_Chip-Seq_HEK293_Human0.94743682
66BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93661431
67AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92928651
68CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92593517
69FOXA1_25329375_ChIP-Seq_VCAP_Human0.91909264
70FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91909264
71ERG_20517297_ChIP-Seq_VCAP_Human0.88048776
72POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87587028
73SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87320634
74PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87197539
75TAF2_19829295_ChIP-Seq_ESCs_Human0.86998462
76HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86492211
77NFE2_27457419_Chip-Seq_LIVER_Mouse0.85866702
78IRF8_21731497_ChIP-ChIP_J774_Mouse0.85844361
79FOXH1_21741376_ChIP-Seq_EPCs_Human0.85179152
80DCP1A_22483619_ChIP-Seq_HELA_Human0.84647346
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84212682
82BCAT_22108803_ChIP-Seq_LS180_Human0.84137038
83GATA3_21878914_ChIP-Seq_MCF-7_Human0.83492251
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82936256
85JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81813928
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81777616
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81496921
88EED_16625203_ChIP-ChIP_MESCs_Mouse0.81479536
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79681865
90SOX2_16153702_ChIP-ChIP_HESCs_Human0.79304756
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78480125
92P53_21459846_ChIP-Seq_SAOS-2_Human0.78425209
93REST_21632747_ChIP-Seq_MESCs_Mouse0.77943984
94MYC_19829295_ChIP-Seq_ESCs_Human0.77759177
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77640779
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77640779
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77640779
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.77623202
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77361979
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.76965264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.96817268
2MP0009379_abnormal_foot_pigmentation4.45462570
3MP0006292_abnormal_olfactory_placode4.18218024
4MP0004147_increased_porphyrin_level2.93575492
5MP0008789_abnormal_olfactory_epithelium2.89056915
6MP0000372_irregular_coat_pigmentation2.32154164
7MP0005671_abnormal_response_to2.27740232
8MP0001529_abnormal_vocalization2.13033085
9MP0005645_abnormal_hypothalamus_physiol2.11945849
10MP0005394_taste/olfaction_phenotype2.11104095
11MP0005499_abnormal_olfactory_system2.11104095
12MP0006072_abnormal_retinal_apoptosis1.96272299
13MP0002277_abnormal_respiratory_mucosa1.92923367
14MP0003880_abnormal_central_pattern1.90575330
15MP0005084_abnormal_gallbladder_morpholo1.90514311
16MP0002138_abnormal_hepatobiliary_system1.89360976
17MP0003787_abnormal_imprinting1.81814290
18MP0004142_abnormal_muscle_tone1.81453409
19MP0006276_abnormal_autonomic_nervous1.79915288
20MP0002163_abnormal_gland_morphology1.74003430
21MP0002234_abnormal_pharynx_morphology1.72266424
22MP0001293_anophthalmia1.67766405
23MP0004145_abnormal_muscle_electrophysio1.67715494
24MP0003878_abnormal_ear_physiology1.66922981
25MP0005377_hearing/vestibular/ear_phenot1.66922981
26MP0000569_abnormal_digit_pigmentation1.63931505
27MP0002653_abnormal_ependyma_morphology1.61588420
28MP0004133_heterotaxia1.61091578
29MP0001905_abnormal_dopamine_level1.57205232
30MP0005551_abnormal_eye_electrophysiolog1.50973570
31MP0004885_abnormal_endolymph1.49380883
32MP0002837_dystrophic_cardiac_calcinosis1.44513677
33MP0002095_abnormal_skin_pigmentation1.44340066
34MP0005360_urolithiasis1.41656131
35MP0005075_abnormal_melanosome_morpholog1.39089480
36MP0005646_abnormal_pituitary_gland1.37049039
37MP0006036_abnormal_mitochondrial_physio1.37046357
38MP0003122_maternal_imprinting1.34587032
39MP0010386_abnormal_urinary_bladder1.31038294
40MP0001919_abnormal_reproductive_system1.30900798
41MP0000631_abnormal_neuroendocrine_gland1.27753059
42MP0003011_delayed_dark_adaptation1.25946269
43MP0001968_abnormal_touch/_nociception1.25374922
44MP0001984_abnormal_olfaction1.21254885
45MP0006035_abnormal_mitochondrial_morpho1.17548047
46MP0003186_abnormal_redox_activity1.17170459
47MP0009333_abnormal_splenocyte_physiolog1.14548249
48MP0002102_abnormal_ear_morphology1.13821681
49MP0005253_abnormal_eye_physiology1.12143385
50MP0002736_abnormal_nociception_after1.10850860
51MP0005195_abnormal_posterior_eye1.07471171
52MP0005389_reproductive_system_phenotype1.06486833
53MP0008872_abnormal_physiological_respon1.05525338
54MP0005379_endocrine/exocrine_gland_phen1.05354357
55MP0003136_yellow_coat_color1.04431675
56MP0005408_hypopigmentation1.04027330
57MP0002148_abnormal_hypersensitivity_rea1.02976974
58MP0003195_calcinosis1.02200440
59MP0002090_abnormal_vision1.01157992
60MP0000015_abnormal_ear_pigmentation0.99927498
61MP0001790_abnormal_immune_system0.99233523
62MP0005387_immune_system_phenotype0.99233523
63MP0001835_abnormal_antigen_presentation0.98888192
64MP0001800_abnormal_humoral_immune0.98281000
65MP0002272_abnormal_nervous_system0.96992508
66MP0009745_abnormal_behavioral_response0.94756022
67MP0008877_abnormal_DNA_methylation0.93205915
68MP0002160_abnormal_reproductive_system0.92878316
69MP0002752_abnormal_somatic_nervous0.92162705
70MP0003866_abnormal_defecation0.91002437
71MP0005636_abnormal_mineral_homeostasis0.89288287
72MP0006082_CNS_inflammation0.88345927
73MP0001485_abnormal_pinna_reflex0.88035454
74MP0005423_abnormal_somatic_nervous0.87149584
75MP0000049_abnormal_middle_ear0.86177283
76MP0009785_altered_susceptibility_to0.85147056
77MP0005391_vision/eye_phenotype0.83688533
78MP0004924_abnormal_behavior0.80785430
79MP0005386_behavior/neurological_phenoty0.80785430
80MP0000685_abnormal_immune_system0.80673888
81MP0003786_premature_aging0.79909265
82MP0008058_abnormal_DNA_repair0.78479629
83MP0001188_hyperpigmentation0.78229596
84MP0002233_abnormal_nose_morphology0.77585222
85MP0002938_white_spotting0.77028973
86MP0000538_abnormal_urinary_bladder0.76014672
87MP0003121_genomic_imprinting0.75866017
88MP0005000_abnormal_immune_tolerance0.73247806
89MP0002928_abnormal_bile_duct0.72906230
90MP0002184_abnormal_innervation0.72715462
91MP0003137_abnormal_impulse_conducting0.72492790
92MP0002723_abnormal_immune_serum0.70345936
93MP0000026_abnormal_inner_ear0.70095261
94MP0001324_abnormal_eye_pigmentation0.69248908
95MP0000778_abnormal_nervous_system0.68986593
96MP0001286_abnormal_eye_development0.68639904
97MP0001881_abnormal_mammary_gland0.67650295
98MP0003806_abnormal_nucleotide_metabolis0.66898509
99MP0009046_muscle_twitch0.65270591
100MP0001970_abnormal_pain_threshold0.61903858

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)5.20330661
2Acute necrotizing encephalopathy (HP:0006965)5.17540736
3Abnormal mitochondria in muscle tissue (HP:0008316)4.90061476
4Mitochondrial inheritance (HP:0001427)4.85360842
5Acute encephalopathy (HP:0006846)4.35336698
6Hepatocellular necrosis (HP:0001404)4.29043174
7Increased hepatocellular lipid droplets (HP:0006565)4.21108481
8Progressive macrocephaly (HP:0004481)4.14937260
9Increased CSF lactate (HP:0002490)4.07256251
10Decreased activity of mitochondrial respiratory chain (HP:0008972)4.05073583
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.05073583
12Lipid accumulation in hepatocytes (HP:0006561)4.03901614
13Increased intramyocellular lipid droplets (HP:0012240)3.82679944
14Abnormality of midbrain morphology (HP:0002418)3.76529809
15Molar tooth sign on MRI (HP:0002419)3.76529809
16Hepatic necrosis (HP:0002605)3.76151641
17Renal Fanconi syndrome (HP:0001994)3.74399826
18Cerebral edema (HP:0002181)3.62118652
19Increased muscle lipid content (HP:0009058)3.28296797
20Aplastic anemia (HP:0001915)3.25346871
21Colon cancer (HP:0003003)3.19015184
22Exertional dyspnea (HP:0002875)3.13145995
23Pancreatic cysts (HP:0001737)3.11278719
24Abolished electroretinogram (ERG) (HP:0000550)3.03825092
25Congenital, generalized hypertrichosis (HP:0004540)2.97673711
26Pancreatic fibrosis (HP:0100732)2.87782257
27Optic disc pallor (HP:0000543)2.83017191
28Myokymia (HP:0002411)2.79014286
29Reticulocytopenia (HP:0001896)2.74793623
30Abnormality of cells of the erythroid lineage (HP:0012130)2.72228380
31Macrocytic anemia (HP:0001972)2.58288578
32Abnormality of renal resorption (HP:0011038)2.55573718
33Abnormal respiratory motile cilium physiology (HP:0012261)2.52110367
34Medial flaring of the eyebrow (HP:0010747)2.52094222
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.48913603
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44829754
37Respiratory failure (HP:0002878)2.44568306
38Abnormal number of erythroid precursors (HP:0012131)2.44454187
39Increased serum lactate (HP:0002151)2.39936010
40Abnormal respiratory epithelium morphology (HP:0012253)2.39399705
41Abnormal respiratory motile cilium morphology (HP:0005938)2.39399705
42Hyperphosphaturia (HP:0003109)2.39373404
43Lactic acidosis (HP:0003128)2.39330057
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.33131813
45Respiratory difficulties (HP:0002880)2.32178702
46Abnormal ciliary motility (HP:0012262)2.30247661
47True hermaphroditism (HP:0010459)2.29577865
48Glycosuria (HP:0003076)2.27691752
49Abnormality of urine glucose concentration (HP:0011016)2.27691752
50Attenuation of retinal blood vessels (HP:0007843)2.27442236
51Leukodystrophy (HP:0002415)2.25782667
52Severe combined immunodeficiency (HP:0004430)2.25471191
53Abnormality of the renal cortex (HP:0011035)2.22598844
54Exercise intolerance (HP:0003546)2.20133810
55Congenital stationary night blindness (HP:0007642)2.19272512
56Pallor (HP:0000980)2.14468857
57Supernumerary spleens (HP:0009799)2.12316430
58Septo-optic dysplasia (HP:0100842)2.05667868
59Pendular nystagmus (HP:0012043)2.05266091
60Thyroiditis (HP:0100646)2.04085387
61Type II lissencephaly (HP:0007260)2.03599043
62Abnormal urine phosphate concentration (HP:0012599)2.00643909
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96875747
64Polydipsia (HP:0001959)1.95792347
65Abnormal drinking behavior (HP:0030082)1.95792347
66Rhinitis (HP:0012384)1.92585543
67X-linked dominant inheritance (HP:0001423)1.92258750
68Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92021353
69Gait imbalance (HP:0002141)1.87519007
70Enlarged kidneys (HP:0000105)1.84826281
71Congenital primary aphakia (HP:0007707)1.82331071
72Lethargy (HP:0001254)1.82132994
73Abnormal rod and cone electroretinograms (HP:0008323)1.81427721
74Optic nerve hypoplasia (HP:0000609)1.79822271
75Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77475723
76Abnormality of the renal medulla (HP:0100957)1.77236054
77Chronic sinusitis (HP:0011109)1.75356449
78Metaphyseal dysplasia (HP:0100255)1.71389070
79Diastasis recti (HP:0001540)1.70249629
80Recurrent cutaneous fungal infections (HP:0011370)1.69719634
81Chronic mucocutaneous candidiasis (HP:0002728)1.69719634
82Severe visual impairment (HP:0001141)1.69450469
83Short tibia (HP:0005736)1.69279111
84Nephronophthisis (HP:0000090)1.68634903
85Cystic liver disease (HP:0006706)1.68135216
86Hypoproteinemia (HP:0003075)1.68040208
87IgG deficiency (HP:0004315)1.66840792
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.65496856
89Oral leukoplakia (HP:0002745)1.65335785
90Anencephaly (HP:0002323)1.64643833
91Sclerocornea (HP:0000647)1.64541542
92Abnormality of eosinophils (HP:0001879)1.64436315
93CNS demyelination (HP:0007305)1.64309071
94Renal cortical cysts (HP:0000803)1.62793266
95Emotional lability (HP:0000712)1.60538370
96Male pseudohermaphroditism (HP:0000037)1.58291138
97Abnormal delayed hypersensitivity skin test (HP:0002963)1.56962440
98Encephalitis (HP:0002383)1.56376820
99Nephrogenic diabetes insipidus (HP:0009806)1.55348741
100Genetic anticipation (HP:0003743)1.54993035

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.35389232
2PINK13.52335588
3BCKDK3.51420801
4ADRBK23.10542130
5KDR2.30409470
6CASK2.30064509
7TLK12.29982219
8MAP4K22.16300123
9BMPR1B2.12134367
10VRK22.10227896
11WNK42.05561170
12CDK191.97178948
13TXK1.96137412
14MATK1.91000413
15DYRK21.90364610
16TAOK31.83399319
17ZAK1.71430201
18STK161.69257016
19NME11.68452902
20WNK31.63463209
21MAPKAPK31.61170724
22MAP3K111.60641351
23NTRK11.58256966
24GRK11.52244294
25VRK11.51906292
26MAP2K71.49061704
27DYRK31.43497608
28NUAK11.30491602
29LIMK11.26489334
30MAP3K41.18109215
31TYRO31.16175059
32WNK11.07666306
33TIE11.07385251
34ITK1.07017574
35FES1.05526603
36OXSR11.04533935
37MAP2K41.02370141
38ABL21.00779805
39BCR0.97375233
40MYLK0.95729781
41EPHB20.92192689
42PASK0.89563993
43DAPK30.88091311
44SRPK10.86951217
45CDK80.86344518
46TESK20.85613010
47NTRK20.82781872
48ADRBK10.82462999
49EIF2AK10.76573570
50CSNK1G30.74963514
51RPS6KA50.74651673
52DAPK10.72220399
53PIK3CG0.72168244
54MAP3K50.71442820
55CSNK1G10.70572384
56PIK3CA0.69758486
57INSRR0.67880964
58CSNK1G20.66586457
59MAP3K60.66489517
60PLK20.63106671
61KIT0.63093278
62TGFBR10.62819080
63GRK70.62572377
64NLK0.61060003
65FRK0.60190749
66PRKCQ0.58202662
67CAMKK20.57073498
68MELK0.56031888
69DYRK1B0.54425241
70BUB10.53676166
71MAP4K10.52628332
72LCK0.52386724
73AURKA0.49046581
74DYRK1A0.48875333
75OBSCN0.48506548
76TRIM280.48349170
77CAMK10.48070420
78STK240.47401831
79EPHA40.46579319
80CDC70.46320064
81IKBKB0.45505902
82CSNK1A1L0.45274579
83LYN0.44442266
84CSNK1A10.43555878
85STK30.43376510
86STK110.42983558
87PRKACA0.41748498
88BMPR20.40230676
89MAPK130.39847828
90SYK0.39423850
91ATR0.38989722
92MINK10.38667339
93AURKB0.37759552
94PRKCG0.37551018
95TEC0.37142792
96MAPK150.37104496
97JAK30.36869162
98PLK40.36818965
99CSNK2A10.36610515
100ARAF0.36596184

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.09294831
2Ribosome_Homo sapiens_hsa030105.01244683
3Parkinsons disease_Homo sapiens_hsa050124.18359522
4Protein export_Homo sapiens_hsa030604.03376493
5Proteasome_Homo sapiens_hsa030503.45444295
6Alzheimers disease_Homo sapiens_hsa050102.87256195
7Huntingtons disease_Homo sapiens_hsa050162.70521346
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.53998158
9Phototransduction_Homo sapiens_hsa047442.51957242
10Graft-versus-host disease_Homo sapiens_hsa053322.44122146
11Cardiac muscle contraction_Homo sapiens_hsa042602.33675494
12Asthma_Homo sapiens_hsa053102.22026919
13Allograft rejection_Homo sapiens_hsa053302.02048637
14Autoimmune thyroid disease_Homo sapiens_hsa053202.00652526
15RNA polymerase_Homo sapiens_hsa030201.85691243
16Primary immunodeficiency_Homo sapiens_hsa053401.74926656
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.65623655
18Type I diabetes mellitus_Homo sapiens_hsa049401.59740553
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59535994
20Antigen processing and presentation_Homo sapiens_hsa046121.39763308
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38897583
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33398828
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26125783
24Systemic lupus erythematosus_Homo sapiens_hsa053221.14225195
25Nitrogen metabolism_Homo sapiens_hsa009101.08329082
26Homologous recombination_Homo sapiens_hsa034401.04964624
27RNA degradation_Homo sapiens_hsa030181.04109392
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04011044
29Rheumatoid arthritis_Homo sapiens_hsa053231.03954914
30Mismatch repair_Homo sapiens_hsa034301.00842019
31Sulfur relay system_Homo sapiens_hsa041220.99411628
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96930422
33Fatty acid elongation_Homo sapiens_hsa000620.93345195
34Collecting duct acid secretion_Homo sapiens_hsa049660.93041106
35Peroxisome_Homo sapiens_hsa041460.91857562
36Tryptophan metabolism_Homo sapiens_hsa003800.91449770
37SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91036414
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90035704
39Linoleic acid metabolism_Homo sapiens_hsa005910.89618497
40Pyrimidine metabolism_Homo sapiens_hsa002400.86248960
41Caffeine metabolism_Homo sapiens_hsa002320.81460785
42Spliceosome_Homo sapiens_hsa030400.80475524
43Chemical carcinogenesis_Homo sapiens_hsa052040.80074881
44Hematopoietic cell lineage_Homo sapiens_hsa046400.80027963
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77031886
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76304145
47One carbon pool by folate_Homo sapiens_hsa006700.75147423
48Regulation of autophagy_Homo sapiens_hsa041400.74507470
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74063743
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71552562
51Propanoate metabolism_Homo sapiens_hsa006400.71448525
52Hedgehog signaling pathway_Homo sapiens_hsa043400.70813490
53Basal transcription factors_Homo sapiens_hsa030220.70341278
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.68416048
55Retinol metabolism_Homo sapiens_hsa008300.66042816
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65742887
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.63016362
58Fanconi anemia pathway_Homo sapiens_hsa034600.62980509
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62481260
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60340283
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57987458
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57942296
63Purine metabolism_Homo sapiens_hsa002300.56854922
64Folate biosynthesis_Homo sapiens_hsa007900.52940586
65Nicotine addiction_Homo sapiens_hsa050330.50737792
66Metabolic pathways_Homo sapiens_hsa011000.50146848
67Alcoholism_Homo sapiens_hsa050340.48553660
68beta-Alanine metabolism_Homo sapiens_hsa004100.48050131
69Arachidonic acid metabolism_Homo sapiens_hsa005900.45434962
70Basal cell carcinoma_Homo sapiens_hsa052170.43895221
71Salmonella infection_Homo sapiens_hsa051320.42975912
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42730734
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41788119
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.41683582
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41029151
76Butanoate metabolism_Homo sapiens_hsa006500.40587840
77Taste transduction_Homo sapiens_hsa047420.39852910
78GABAergic synapse_Homo sapiens_hsa047270.39772246
79DNA replication_Homo sapiens_hsa030300.38225788
80Nucleotide excision repair_Homo sapiens_hsa034200.37276592
81Olfactory transduction_Homo sapiens_hsa047400.34658315
82RNA transport_Homo sapiens_hsa030130.33099936
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31979310
84Viral myocarditis_Homo sapiens_hsa054160.31376293
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31036579
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29345036
87Histidine metabolism_Homo sapiens_hsa003400.29267869
88Fatty acid degradation_Homo sapiens_hsa000710.29211346
89Morphine addiction_Homo sapiens_hsa050320.28866755
90Staphylococcus aureus infection_Homo sapiens_hsa051500.28124030
91Ether lipid metabolism_Homo sapiens_hsa005650.28095427
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.26495210
93Sulfur metabolism_Homo sapiens_hsa009200.23726145
94Steroid biosynthesis_Homo sapiens_hsa001000.23237734
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21254305
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21180047
97Mineral absorption_Homo sapiens_hsa049780.19144966
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17763299
99Renin-angiotensin system_Homo sapiens_hsa046140.17038505
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16398997

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