ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	monocyte chemotaxis (GO:0002548)	6.01556638
2	DNA deamination (GO:0045006)	5.46896871
3	negative regulation of T-helper cell differentiation (GO:0045623)	5.37611409
4	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	5.37611409
5	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	4.68336785
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.63776923
7	regulation of immunoglobulin secretion (GO:0051023)	4.58577719
8	regulation of T cell chemotaxis (GO:0010819)	4.47716741
9	positive regulation of T cell chemotaxis (GO:0010820)	4.47716741
10	negative regulation of alpha-beta T cell differentiation (GO:0046639)	4.20178043
11	proteasome assembly (GO:0043248)	4.14475122
12	cytidine metabolic process (GO:0046087)	4.09950328
13	cytidine catabolic process (GO:0006216)	4.09950328
14	cytidine deamination (GO:0009972)	4.09950328
15	nucleotide transmembrane transport (GO:1901679)	4.08008400
16	regulation of chronic inflammatory response (GO:0002676)	4.03694011
17	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.94469817
18	rRNA modification (GO:0000154)	3.89926427
19	pseudouridine synthesis (GO:0001522)	3.79447567
20	AMP metabolic process (GO:0046033)	3.77793247
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.77685950
22	platelet dense granule organization (GO:0060155)	3.75830123
23	rRNA methylation (GO:0031167)	3.73750971
24	chaperone-mediated protein transport (GO:0072321)	3.70286249
25	histone mRNA metabolic process (GO:0008334)	3.65225894
26	DNA double-strand break processing (GO:0000729)	3.62798735
27	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.61321262
28	eosinophil chemotaxis (GO:0048245)	3.57905723
29	fucose catabolic process (GO:0019317)	3.57617632
30	L-fucose metabolic process (GO:0042354)	3.57617632
31	L-fucose catabolic process (GO:0042355)	3.57617632
32	C-terminal protein lipidation (GO:0006501)	3.51428799
33	forebrain neuron differentiation (GO:0021879)	3.47969123
34	interferon-gamma production (GO:0032609)	3.41398095
35	IMP metabolic process (GO:0046040)	3.40862124
36	cellular response to interleukin-15 (GO:0071350)	3.39585454
37	negative regulation of T cell differentiation (GO:0045581)	3.39348220
38	positive regulation of granulocyte differentiation (GO:0030854)	3.37416843
39	signal peptide processing (GO:0006465)	3.36813952
40	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.32291065
41	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	3.24383868
42	T-helper cell differentiation (GO:0042093)	3.24383868
43	eosinophil migration (GO:0072677)	3.22270138
44	preassembly of GPI anchor in ER membrane (GO:0016254)	3.21157193
45	positive regulation of mitochondrial fission (GO:0090141)	3.18968426
46	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.17829490
47	regulation of isotype switching to IgG isotypes (GO:0048302)	3.11443285
48	positive regulation of prostaglandin secretion (GO:0032308)	3.06831009
49	negative regulation of alpha-beta T cell activation (GO:0046636)	3.06629195
50	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.03394950
51	iron-sulfur cluster assembly (GO:0016226)	3.02845966
52	metallo-sulfur cluster assembly (GO:0031163)	3.02845966
53	protein K6-linked ubiquitination (GO:0085020)	3.01033242
54	response to interleukin-15 (GO:0070672)	2.97972422
55	ribosome assembly (GO:0042255)	2.95525603
56	mannosylation (GO:0097502)	2.94337968
57	regulation of T cell receptor signaling pathway (GO:0050856)	2.90366017
58	T cell differentiation involved in immune response (GO:0002292)	2.89977707
59	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.89977707
60	alpha-beta T cell activation involved in immune response (GO:0002287)	2.89977707
61	GPI anchor biosynthetic process (GO:0006506)	2.88757360
62	C-terminal protein amino acid modification (GO:0018410)	2.88697563
63	histone mRNA catabolic process (GO:0071044)	2.85668278
64	double-strand break repair via homologous recombination (GO:0000724)	2.84359656
65	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.83814930
66	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.83814930
67	positive regulation of fatty acid transport (GO:2000193)	2.83085009
68	DNA catabolic process, exonucleolytic (GO:0000738)	2.83051327
69	GPI anchor metabolic process (GO:0006505)	2.82903127
70	positive regulation of T cell cytokine production (GO:0002726)	2.81071368
71	branched-chain amino acid catabolic process (GO:0009083)	2.80684979
72	protein neddylation (GO:0045116)	2.79656013
73	recombinational repair (GO:0000725)	2.78512280
74	electron transport chain (GO:0022900)	2.73905271
75	adaptation of signaling pathway (GO:0023058)	2.73241388
76	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.72772420
77	respiratory electron transport chain (GO:0022904)	2.72651053
78	hypothalamus development (GO:0021854)	2.71344451
79	positive regulation of protein homodimerization activity (GO:0090073)	2.69639363
80	S-adenosylmethionine metabolic process (GO:0046500)	2.67827428
81	negative regulation of B cell proliferation (GO:0030889)	2.67448613
82	positive regulation of heat generation (GO:0031652)	2.67277016
83	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.66788151
84	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.66549974
85	termination of RNA polymerase III transcription (GO:0006386)	2.66549974
86	GTP biosynthetic process (GO:0006183)	2.62686550
87	protein targeting to mitochondrion (GO:0006626)	2.62310068
88	protein complex biogenesis (GO:0070271)	2.59700021
89	negative regulation of lymphocyte differentiation (GO:0045620)	2.59033202
90	regulation of regulatory T cell differentiation (GO:0045589)	2.55839200
91	negative regulation of B cell activation (GO:0050869)	2.55580581
92	positive regulation of protein sumoylation (GO:0033235)	2.55534275
93	negative regulation of T cell receptor signaling pathway (GO:0050860)	2.54648188
94	negative regulation of mast cell activation (GO:0033004)	2.54465447
95	establishment of protein localization to mitochondrion (GO:0072655)	2.53961415
96	positive regulation of icosanoid secretion (GO:0032305)	2.53847065
97	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.47791535
98	tyrosine phosphorylation of STAT protein (GO:0007260)	2.47526862
99	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.45946080
100	positive regulation of translational initiation (GO:0045948)	2.45063396

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.37811981
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.92332445
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.77834986
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.50946144
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.34302268
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.98283510
7	VDR_23849224_ChIP-Seq_CD4+_Human	2.91378407
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.81470063
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.80816038
10	VDR_22108803_ChIP-Seq_LS180_Human	2.67362099
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.55753614
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.49617814
13	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.38706882
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.36516959
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.32678976
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.31124685
17	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	2.23873278
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.22258042
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.18997331
20	TAF15_26573619_Chip-Seq_HEK293_Human	2.15980391
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.10679455
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.03966147
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.03853783
24	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.02851481
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.90311755
26	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.82744588
27	DCP1A_22483619_ChIP-Seq_HELA_Human	1.80787729
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.77044229
29	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.76012883
30	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.73112921
31	EWS_26573619_Chip-Seq_HEK293_Human	1.69373320
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67117445
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66447961
34	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.61590365
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.60332606
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.57842275
37	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.54700316
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.54494796
39	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.50533016
40	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.49714595
41	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.48483423
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47375480
43	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.46864226
44	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.39187853
45	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.38163206
46	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.37208890
47	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.34946557
48	IGF1R_20145208_ChIP-Seq_DFB_Human	1.34077469
49	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.32335666
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.31873009
51	FUS_26573619_Chip-Seq_HEK293_Human	1.26107903
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.25046081
53	P300_19829295_ChIP-Seq_ESCs_Human	1.23866567
54	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.20356167
55	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20160537
56	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.15441646
57	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.11973933
58	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.11875721
59	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.10466808
60	NCOR_22424771_ChIP-Seq_293T_Human	1.09299219
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07096185
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.07096185
63	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.04722645
64	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04705271
65	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.04648272
66	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.03622565
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.02531726
68	RBPJ_21746931_ChIP-Seq_IB4_Human	1.02095007
69	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.01749858
70	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.01356091
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01026230
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01026230
73	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00579161
74	MYB_26560356_Chip-Seq_TH2_Human	0.99544132
75	GATA3_26560356_Chip-Seq_TH2_Human	0.97536385
76	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97439728
77	PHF8_20622853_ChIP-Seq_HELA_Human	0.97338036
78	KDM5A_27292631_Chip-Seq_BREAST_Human	0.97107808
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.97035725
80	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.95641593
81	AR_20517297_ChIP-Seq_VCAP_Human	0.95353992
82	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.95313945
83	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.93986844
84	GATA3_26560356_Chip-Seq_TH1_Human	0.93421472
85	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93347050
86	GABP_19822575_ChIP-Seq_HepG2_Human	0.93324796
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.93124850
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.93124850
89	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.92823679
90	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.92804268
91	TP53_16413492_ChIP-PET_HCT116_Human	0.92775177
92	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.92756490
93	GATA3_27048872_Chip-Seq_THYMUS_Human	0.90903531
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.90478448
95	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89945696
96	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.89053250
97	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.88921858
98	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.88913564
99	NFYB_21822215_ChIP-Seq_K562_Human	0.88589254
100	P300_18555785_Chip-Seq_ESCs_Mouse	0.88306541

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001873_stomach_inflammation	4.38450387
2	MP0005645_abnormal_hypothalamus_physiol	4.02344749
3	MP0003195_calcinosis	3.13769458
4	MP0003880_abnormal_central_pattern	3.03668750
5	MP0005379_endocrine/exocrine_gland_phen	2.82770725
6	MP0005671_abnormal_response_to	2.82219169
7	MP0003787_abnormal_imprinting	2.73791162
8	MP0003763_abnormal_thymus_physiology	2.68456603
9	MP0003786_premature_aging	2.58075507
10	MP0008058_abnormal_DNA_repair	2.46640814
11	MP0005167_abnormal_blood-brain_barrier	2.46050969
12	MP0008875_abnormal_xenobiotic_pharmacok	2.38916129
13	MP0002653_abnormal_ependyma_morphology	2.37511645
14	MP0006072_abnormal_retinal_apoptosis	2.30075908
15	MP0003011_delayed_dark_adaptation	2.29689255
16	MP0005075_abnormal_melanosome_morpholog	2.21382343
17	MP0006082_CNS_inflammation	2.12219024
18	MP0005310_abnormal_salivary_gland	2.10698555
19	MP0008877_abnormal_DNA_methylation	1.94365991
20	MP0006292_abnormal_olfactory_placode	1.92585629
21	MP0002138_abnormal_hepatobiliary_system	1.87094785
22	MP0009333_abnormal_splenocyte_physiolog	1.84731824
23	MP0006276_abnormal_autonomic_nervous	1.78499347
24	MP0000685_abnormal_immune_system	1.78446399
25	MP0005423_abnormal_somatic_nervous	1.78005603
26	MP0004147_increased_porphyrin_level	1.67537716
27	MP0002163_abnormal_gland_morphology	1.66876562
28	MP0005646_abnormal_pituitary_gland	1.66533132
29	MP0001188_hyperpigmentation	1.62369888
30	MP0001984_abnormal_olfaction	1.59763556
31	MP0002254_reproductive_system_inflammat	1.58217261
32	MP0004145_abnormal_muscle_electrophysio	1.56474117
33	MP0002638_abnormal_pupillary_reflex	1.49783122
34	MP0004142_abnormal_muscle_tone	1.48735257
35	MP0004381_abnormal_hair_follicle	1.45479491
36	MP0003693_abnormal_embryo_hatching	1.43663874
37	MP0002751_abnormal_autonomic_nervous	1.42298523
38	MP0001905_abnormal_dopamine_level	1.38776232
39	MP0001348_abnormal_lacrimal_gland	1.37416012
40	MP0002234_abnormal_pharynx_morphology	1.34272772
41	MP0005253_abnormal_eye_physiology	1.32416914
42	MP0005387_immune_system_phenotype	1.31104925
43	MP0001790_abnormal_immune_system	1.31104925
44	MP0001800_abnormal_humoral_immune	1.26009502
45	MP0008872_abnormal_physiological_respon	1.24666205
46	MP0003718_maternal_effect	1.22727985
47	MP0003121_genomic_imprinting	1.16248617
48	MP0005083_abnormal_biliary_tract	1.15416620
49	MP0000639_abnormal_adrenal_gland	1.14908705
50	MP0000372_irregular_coat_pigmentation	1.14518075
51	MP0005551_abnormal_eye_electrophysiolog	1.11476270
52	MP0002909_abnormal_adrenal_gland	1.10624406
53	MP0001764_abnormal_homeostasis	1.07074004
54	MP0003866_abnormal_defecation	1.05506399
55	MP0000689_abnormal_spleen_morphology	1.04571289
56	MP0000703_abnormal_thymus_morphology	1.02673105
57	MP0010094_abnormal_chromosome_stability	1.00906124
58	MP0001853_heart_inflammation	0.99766377
59	MP0000631_abnormal_neuroendocrine_gland	0.99749008
60	MP0005647_abnormal_sex_gland	0.93970049
61	MP0009384_cardiac_valve_regurgitation	0.93267027
62	MP0006036_abnormal_mitochondrial_physio	0.92432272
63	MP0002160_abnormal_reproductive_system	0.91776277
64	MP0003045_fibrosis	0.91402916
65	MP0002723_abnormal_immune_serum	0.90103719
66	MP0002148_abnormal_hypersensitivity_rea	0.89835633
67	MP0002277_abnormal_respiratory_mucosa	0.89609897
68	MP0004133_heterotaxia	0.89367237
69	MP0002405_respiratory_system_inflammati	0.89340127
70	MP0005389_reproductive_system_phenotype	0.89092216
71	MP0002693_abnormal_pancreas_physiology	0.89086475
72	MP0000613_abnormal_salivary_gland	0.88621131
73	MP0003122_maternal_imprinting	0.87274398
74	MP0002090_abnormal_vision	0.87114506
75	MP0002876_abnormal_thyroid_physiology	0.84575262
76	MP0001835_abnormal_antigen_presentation	0.83630735
77	MP0005410_abnormal_fertilization	0.82179685
78	MP0003567_abnormal_fetal_cardiomyocyte	0.81988724
79	MP0009046_muscle_twitch	0.81611813
80	MP0005636_abnormal_mineral_homeostasis	0.80942058
81	MP0000647_abnormal_sebaceous_gland	0.77889445
82	MP0002398_abnormal_bone_marrow	0.75247897
83	MP0004957_abnormal_blastocyst_morpholog	0.72923084
84	MP0001919_abnormal_reproductive_system	0.72467307
85	MP0001819_abnormal_immune_cell	0.72440944
86	MP0002420_abnormal_adaptive_immunity	0.71829890
87	MP0001986_abnormal_taste_sensitivity	0.69745140
88	MP0002452_abnormal_antigen_presenting	0.69410955
89	MP0003936_abnormal_reproductive_system	0.69236109
90	MP0005395_other_phenotype	0.68267419
91	MP0000716_abnormal_immune_system	0.67816265
92	MP0002722_abnormal_immune_system	0.67693156
93	MP0005332_abnormal_amino_acid	0.67358379
94	MP0001968_abnormal_touch/_nociception	0.67235740
95	MP0003806_abnormal_nucleotide_metabolis	0.64772167
96	MP0010307_abnormal_tumor_latency	0.64691588
97	MP0005084_abnormal_gallbladder_morpholo	0.63658833
98	MP0004215_abnormal_myocardial_fiber	0.63423517
99	MP0004885_abnormal_endolymph	0.63403818
100	MP0001944_abnormal_pancreas_morphology	0.63329497

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	4.21466258
2	Lipid accumulation in hepatocytes (HP:0006561)	4.01731351
3	Thyroiditis (HP:0100646)	3.92917192
4	Severe combined immunodeficiency (HP:0004430)	3.87698734
5	Abnormality of midbrain morphology (HP:0002418)	3.69456129
6	Molar tooth sign on MRI (HP:0002419)	3.69456129
7	IgG deficiency (HP:0004315)	3.63975936
8	3-Methylglutaconic aciduria (HP:0003535)	3.57354135
9	Acute necrotizing encephalopathy (HP:0006965)	3.31633349
10	Mitochondrial inheritance (HP:0001427)	3.29995432
11	Abnormality of homocysteine metabolism (HP:0010919)	3.27390343
12	Homocystinuria (HP:0002156)	3.27390343
13	T lymphocytopenia (HP:0005403)	3.24357072
14	Abnormality of methionine metabolism (HP:0010901)	3.19337802
15	Chronic mucocutaneous candidiasis (HP:0002728)	3.18740211
16	Recurrent cutaneous fungal infections (HP:0011370)	3.18740211
17	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.15429313
18	Renal Fanconi syndrome (HP:0001994)	3.14190532
19	Stomatitis (HP:0010280)	3.14065788
20	Methylmalonic acidemia (HP:0002912)	3.10745126
21	Acute encephalopathy (HP:0006846)	3.09301902
22	Methylmalonic aciduria (HP:0012120)	3.03787160
23	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.00746507
24	Combined immunodeficiency (HP:0005387)	2.95174761
25	Abnormal albumin level (HP:0012116)	2.93911191
26	Hypoalbuminemia (HP:0003073)	2.93911191
27	Increased CSF lactate (HP:0002490)	2.92084509
28	Hypoplasia of the thymus (HP:0000778)	2.88606317
29	Abnormality of T cell number (HP:0011839)	2.87063519
30	Progressive macrocephaly (HP:0004481)	2.86080756
31	Abnormality of vitamin B metabolism (HP:0004340)	2.85668236
32	Hypoproteinemia (HP:0003075)	2.81638326
33	Abnormal mitochondria in muscle tissue (HP:0008316)	2.73770297
34	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.68505441
35	Hepatocellular necrosis (HP:0001404)	2.52193840
36	Elevated erythrocyte sedimentation rate (HP:0003565)	2.51217653
37	Neonatal respiratory distress (HP:0002643)	2.50579293
38	Congenital, generalized hypertrichosis (HP:0004540)	2.50419205
39	Abolished electroretinogram (ERG) (HP:0000550)	2.46950811
40	Abnormality of eosinophils (HP:0001879)	2.44729259
41	Hypothermia (HP:0002045)	2.43808983
42	Cerebral edema (HP:0002181)	2.43286638
43	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.42104704
44	Exertional dyspnea (HP:0002875)	2.41901671
45	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.40547053
46	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.40547053
47	Pigmentary retinal degeneration (HP:0001146)	2.39733575
48	Menstrual irregularities (HP:0000858)	2.37723927
49	Ependymoma (HP:0002888)	2.37576170
50	Microvesicular hepatic steatosis (HP:0001414)	2.37013852
51	Tubular atrophy (HP:0000092)	2.32992355
52	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.31102486
53	Nephronophthisis (HP:0000090)	2.27830910
54	Medial flaring of the eyebrow (HP:0010747)	2.27436034
55	Increased intramyocellular lipid droplets (HP:0012240)	2.27346686
56	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.24400662
57	Tongue fasciculations (HP:0001308)	2.23292827
58	Agitation (HP:0000713)	2.20109081
59	Type I transferrin isoform profile (HP:0003642)	2.19592248
60	Increased serum lactate (HP:0002151)	2.18808545
61	Large for gestational age (HP:0001520)	2.15593346
62	Testicular atrophy (HP:0000029)	2.14816226
63	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.13380153
64	Polydipsia (HP:0001959)	2.07054729
65	Abnormal drinking behavior (HP:0030082)	2.07054729
66	Abnormality of the prostate (HP:0008775)	2.06361551
67	Hepatic necrosis (HP:0002605)	2.06049502
68	Pendular nystagmus (HP:0012043)	2.02802819
69	Pancreatic cysts (HP:0001737)	2.02682991
70	Pancytopenia (HP:0001876)	2.00577497
71	Abnormality of the astrocytes (HP:0100707)	2.00051704
72	Astrocytoma (HP:0009592)	2.00051704
73	Adrenal hypoplasia (HP:0000835)	1.98551508
74	Abnormality of T cells (HP:0002843)	1.98542167
75	Abnormal biliary tract physiology (HP:0012439)	1.95431639
76	Bile duct proliferation (HP:0001408)	1.95431639
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.93797524
78	Abnormal protein N-linked glycosylation (HP:0012347)	1.93797524
79	Abnormal protein glycosylation (HP:0012346)	1.93797524
80	Abnormal glycosylation (HP:0012345)	1.93797524
81	Degeneration of anterior horn cells (HP:0002398)	1.93149513
82	Abnormality of the anterior horn cell (HP:0006802)	1.93149513
83	Aplastic anemia (HP:0001915)	1.93072152
84	Bifid tongue (HP:0010297)	1.92939895
85	Resting tremor (HP:0002322)	1.92182735
86	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.91386590
87	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.90651222
88	Dicarboxylic aciduria (HP:0003215)	1.90651222
89	Increased muscle lipid content (HP:0009058)	1.88515068
90	Lactic acidosis (HP:0003128)	1.87642357
91	Abnormality of the renal medulla (HP:0100957)	1.87278480
92	True hermaphroditism (HP:0010459)	1.84817058
93	Respiratory difficulties (HP:0002880)	1.83120431
94	Abnormality of the labia minora (HP:0012880)	1.82297528
95	Abnormality of renal resorption (HP:0011038)	1.81744933
96	Megaloblastic anemia (HP:0001889)	1.78662205
97	Lethargy (HP:0001254)	1.77540118
98	Muscle fibrillation (HP:0010546)	1.77107908
99	Abnormality of serum amino acid levels (HP:0003112)	1.76256675
100	IgM deficiency (HP:0002850)	1.76062869

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	4.32872712
2	TXK	4.26216285
3	EPHA3	3.21374738
4	NLK	3.18266378
5	NUAK1	3.16838637
6	EIF2AK3	3.04461044
7	TSSK6	2.84693452
8	FRK	2.71282771
9	MST4	2.44214399
10	IRAK2	2.36042164
11	CCNB1	2.24695530
12	IRAK1	2.13878218
13	SRPK1	2.13061733
14	MAP3K9	2.10963313
15	VRK2	2.03834077
16	NME1	1.83351848
17	MAPKAPK3	1.80485638
18	ADRBK2	1.72764333
19	FES	1.71824390
20	FER	1.69950853
21	TRIM28	1.64896031
22	TEC	1.53772606
23	ITK	1.48095766
24	IKBKE	1.41788862
25	TNK2	1.38410370
26	NEK1	1.34630987
27	WNK3	1.31544074
28	IKBKB	1.31436594
29	VRK1	1.30217035
30	CSNK1G1	1.28164401
31	BMPR1B	1.27470696
32	CAMKK2	1.27188227
33	PLK4	1.18433539
34	GRK1	1.17522837
35	BUB1	1.17269221
36	PLK2	1.08185984
37	PINK1	1.05332628
38	WNK4	1.04865304
39	LIMK1	1.01348446
40	DMPK	0.99260464
41	PLK3	0.97445827
42	BCR	0.90904658
43	STK16	0.90610319
44	CSNK1G3	0.81715156
45	FGR	0.78722152
46	ZAK	0.76876340
47	EIF2AK2	0.75635340
48	STK3	0.73012287
49	DYRK2	0.71598853
50	EIF2AK1	0.71583503
51	PRKCG	0.67489436
52	CSNK1G2	0.64595922
53	CSNK1A1L	0.63340983
54	MAP4K2	0.63340701
55	ALK	0.63224102
56	TIE1	0.63136783
57	LMTK2	0.58565596
58	TAOK1	0.57491885
59	TLK1	0.57273310
60	AKT3	0.56591599
61	MAP3K4	0.56358486
62	PHKG1	0.53475512
63	PHKG2	0.53475512
64	SCYL2	0.53065344
65	ATR	0.52932584
66	CAMK2A	0.50826530
67	TNIK	0.49567505
68	STK11	0.49307585
69	PTK2B	0.49007541
70	ACVR1B	0.48122600
71	LATS1	0.45692513
72	CHUK	0.45441871
73	BMPR2	0.44859139
74	BTK	0.43476191
75	LCK	0.43112565
76	TBK1	0.42048050
77	IRAK4	0.41564708
78	INSRR	0.40398498
79	STK38L	0.36872130
80	MARK3	0.36721057
81	MKNK1	0.36207040
82	BCKDK	0.33899993
83	MAP2K7	0.32104845
84	MKNK2	0.31577055
85	PIK3CG	0.31094509
86	FGFR2	0.29955180
87	PRKCQ	0.29873018
88	UHMK1	0.29329880
89	CSNK2A1	0.27562393
90	MATK	0.26547518
91	CSNK1A1	0.26352027
92	PRKG1	0.26324610
93	PRKCI	0.25657137
94	DAPK1	0.25117028
95	MAP3K12	0.24225130
96	MAPK13	0.23743795
97	CAMK4	0.23613041
98	GSK3A	0.22944493
99	CAMK1	0.21882451
100	TAF1	0.21567442

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.78194319
2	Protein export_Homo sapiens_hsa03060	3.61761517
3	Proteasome_Homo sapiens_hsa03050	3.45008429
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.41267641
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.95221107
6	Parkinsons disease_Homo sapiens_hsa05012	2.60138040
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.47572663
8	Propanoate metabolism_Homo sapiens_hsa00640	2.45441168
9	RNA polymerase_Homo sapiens_hsa03020	2.25126923
10	Homologous recombination_Homo sapiens_hsa03440	2.22361842
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.19902761
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.17771174
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.16751618
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.97803114
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.92955177
16	Allograft rejection_Homo sapiens_hsa05330	1.75900271
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.69951598
18	Basal transcription factors_Homo sapiens_hsa03022	1.64238446
19	Mismatch repair_Homo sapiens_hsa03430	1.56866577
20	Folate biosynthesis_Homo sapiens_hsa00790	1.54973751
21	Huntingtons disease_Homo sapiens_hsa05016	1.54578458
22	Alzheimers disease_Homo sapiens_hsa05010	1.48309616
23	RNA degradation_Homo sapiens_hsa03018	1.44649017
24	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.42791270
25	Ribosome_Homo sapiens_hsa03010	1.37816216
26	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.35937785
27	Fatty acid elongation_Homo sapiens_hsa00062	1.33497859
28	Asthma_Homo sapiens_hsa05310	1.29840849
29	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.29458112
30	Purine metabolism_Homo sapiens_hsa00230	1.28475439
31	Spliceosome_Homo sapiens_hsa03040	1.24249475
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.21424445
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.17870311
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.16191239
35	Nucleotide excision repair_Homo sapiens_hsa03420	1.15916311
36	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.15111304
37	RNA transport_Homo sapiens_hsa03013	1.13142951
38	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.12545904
39	Non-homologous end-joining_Homo sapiens_hsa03450	1.11904156
40	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.10186365
41	Collecting duct acid secretion_Homo sapiens_hsa04966	1.09436186
42	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.09387427
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.07523342
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04065321
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.03708193
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.99958385
47	Graft-versus-host disease_Homo sapiens_hsa05332	0.94532865
48	Phototransduction_Homo sapiens_hsa04744	0.93276392
49	Butanoate metabolism_Homo sapiens_hsa00650	0.92665722
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.92219136
51	Sulfur metabolism_Homo sapiens_hsa00920	0.91753857
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.89228502
53	Sulfur relay system_Homo sapiens_hsa04122	0.88423611
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83768632
55	Type I diabetes mellitus_Homo sapiens_hsa04940	0.82274628
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.80110026
57	Antigen processing and presentation_Homo sapiens_hsa04612	0.78569964
58	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.78427432
59	Measles_Homo sapiens_hsa05162	0.77232833
60	Fatty acid degradation_Homo sapiens_hsa00071	0.73346825
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.72877045
62	Regulation of autophagy_Homo sapiens_hsa04140	0.71574699
63	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.71349725
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.68903828
65	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.68725104
66	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67991866
67	Peroxisome_Homo sapiens_hsa04146	0.66942228
68	Metabolic pathways_Homo sapiens_hsa01100	0.65728009
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64449465
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63222884
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.60271076
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60168645
73	Rheumatoid arthritis_Homo sapiens_hsa05323	0.58592980
74	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57683470
75	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.56846845
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.56417339
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55821094
78	Morphine addiction_Homo sapiens_hsa05032	0.55361502
79	mRNA surveillance pathway_Homo sapiens_hsa03015	0.55306653
80	Selenocompound metabolism_Homo sapiens_hsa00450	0.48855323
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.48660914
82	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.47407093
83	Retinol metabolism_Homo sapiens_hsa00830	0.44726808
84	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42509720
85	Caffeine metabolism_Homo sapiens_hsa00232	0.42459952
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41482167
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41363519
88	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.41051155
89	Chemokine signaling pathway_Homo sapiens_hsa04062	0.40499550
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39916307
91	Ether lipid metabolism_Homo sapiens_hsa00565	0.39230875
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38658992
93	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.37540361
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.36619139
95	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35422152
96	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32853956
97	Serotonergic synapse_Homo sapiens_hsa04726	0.31463823
98	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.30996186
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.26949466
100	One carbon pool by folate_Homo sapiens_hsa00670	0.26664755

TCEB1P31

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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