ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.71102859
2	fucose catabolic process (GO:0019317)	4.18866442
3	L-fucose metabolic process (GO:0042354)	4.18866442
4	L-fucose catabolic process (GO:0042355)	4.18866442
5	DNA deamination (GO:0045006)	4.14816767
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.14068736
7	kidney morphogenesis (GO:0060993)	4.09312723
8	water-soluble vitamin biosynthetic process (GO:0042364)	3.87080400
9	platelet dense granule organization (GO:0060155)	3.80379258
10	negative regulation of telomere maintenance (GO:0032205)	3.57771490
11	response to pheromone (GO:0019236)	3.55743241
12	nonmotile primary cilium assembly (GO:0035058)	3.46534153
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.45916249
14	epithelial cilium movement (GO:0003351)	3.40720514
15	indolalkylamine metabolic process (GO:0006586)	3.33152420
16	kynurenine metabolic process (GO:0070189)	3.29867209
17	indole-containing compound catabolic process (GO:0042436)	3.21705745
18	indolalkylamine catabolic process (GO:0046218)	3.21705745
19	tryptophan catabolic process (GO:0006569)	3.21705745
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.21550807
21	piRNA metabolic process (GO:0034587)	3.12508966
22	protein polyglutamylation (GO:0018095)	3.11129831
23	protein complex biogenesis (GO:0070271)	3.02403564
24	primary amino compound metabolic process (GO:1901160)	2.99134238
25	nephron tubule morphogenesis (GO:0072078)	2.98223214
26	nephron epithelium morphogenesis (GO:0072088)	2.98223214
27	ATP synthesis coupled proton transport (GO:0015986)	2.97097332
28	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.97097332
29	somite development (GO:0061053)	2.96948151
30	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.96945581
31	axoneme assembly (GO:0035082)	2.94533422
32	neuron fate determination (GO:0048664)	2.94042334
33	negative regulation of mast cell activation (GO:0033004)	2.90470705
34	detection of light stimulus involved in sensory perception (GO:0050962)	2.89439765
35	detection of light stimulus involved in visual perception (GO:0050908)	2.89439765
36	gamma-aminobutyric acid transport (GO:0015812)	2.88729693
37	serotonin metabolic process (GO:0042428)	2.87967259
38	respiratory chain complex IV assembly (GO:0008535)	2.87530014
39	neural tube formation (GO:0001841)	2.85828287
40	ubiquinone biosynthetic process (GO:0006744)	2.85582452
41	behavioral response to ethanol (GO:0048149)	2.84633221
42	glycerophospholipid catabolic process (GO:0046475)	2.84298889
43	neuronal action potential (GO:0019228)	2.83535722
44	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.83229777
45	pyrimidine nucleobase catabolic process (GO:0006208)	2.83023763
46	mitochondrial respiratory chain complex assembly (GO:0033108)	2.82525923
47	regulation of action potential (GO:0098900)	2.81969655
48	preassembly of GPI anchor in ER membrane (GO:0016254)	2.81536001
49	indole-containing compound metabolic process (GO:0042430)	2.80897755
50	tryptophan metabolic process (GO:0006568)	2.80541598
51	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.80196227
52	NADH dehydrogenase complex assembly (GO:0010257)	2.80196227
53	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.80196227
54	cilium movement (GO:0003341)	2.79937725
55	regulation of hexokinase activity (GO:1903299)	2.79791212
56	regulation of glucokinase activity (GO:0033131)	2.79791212
57	cilium morphogenesis (GO:0060271)	2.78712626
58	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.78245254
59	cornea development in camera-type eye (GO:0061303)	2.76916619
60	protein-cofactor linkage (GO:0018065)	2.76293807
61	cellular ketone body metabolic process (GO:0046950)	2.74743375
62	ubiquinone metabolic process (GO:0006743)	2.73556575
63	regulation of cilium movement (GO:0003352)	2.73372673
64	protein neddylation (GO:0045116)	2.72916941
65	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.72805881
66	cytochrome complex assembly (GO:0017004)	2.67142648
67	retinal ganglion cell axon guidance (GO:0031290)	2.66939285
68	cytidine metabolic process (GO:0046087)	2.66682180
69	cytidine catabolic process (GO:0006216)	2.66682180
70	cytidine deamination (GO:0009972)	2.66682180
71	protein localization to cilium (GO:0061512)	2.65103027
72	sulfation (GO:0051923)	2.64696056
73	synaptic transmission, cholinergic (GO:0007271)	2.63222385
74	regulation of mesoderm development (GO:2000380)	2.62711376
75	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.61878868
76	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.61020852
77	somite rostral/caudal axis specification (GO:0032525)	2.60460458
78	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.56954832
79	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.56954832
80	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.56842898
81	reflex (GO:0060004)	2.56297160
82	cilium or flagellum-dependent cell motility (GO:0001539)	2.54734100
83	cilium organization (GO:0044782)	2.54655195
84	maturation of 5.8S rRNA (GO:0000460)	2.52168622
85	nucleobase catabolic process (GO:0046113)	2.49199967
86	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.48537455
87	regulation of microtubule-based movement (GO:0060632)	2.48358849
88	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.47914149
89	ketone body metabolic process (GO:1902224)	2.47407337
90	renal tubule morphogenesis (GO:0061333)	2.46055310
91	photoreceptor cell maintenance (GO:0045494)	2.45090364
92	cilium assembly (GO:0042384)	2.44811866
93	regulation of telomere maintenance (GO:0032204)	2.43838128
94	cell proliferation in forebrain (GO:0021846)	2.42180470
95	presynaptic membrane assembly (GO:0097105)	2.42059130
96	axonemal dynein complex assembly (GO:0070286)	2.41043814
97	postsynaptic membrane organization (GO:0001941)	2.40822805
98	reciprocal DNA recombination (GO:0035825)	2.39207304
99	reciprocal meiotic recombination (GO:0007131)	2.39207304
100	photoreceptor cell development (GO:0042461)	2.38785285

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.05251334
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.20290589
3	VDR_22108803_ChIP-Seq_LS180_Human	3.14647878
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.84113017
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.69420060
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.63224512
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.51022154
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.28271616
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.22746193
10	FUS_26573619_Chip-Seq_HEK293_Human	2.15483402
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14658100
12	EWS_26573619_Chip-Seq_HEK293_Human	2.10999385
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10591110
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.07496881
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06685457
16	P300_19829295_ChIP-Seq_ESCs_Human	1.98193362
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.97760293
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.86469407
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79646269
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.74800625
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.72704965
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.71364782
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.68686346
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67493594
25	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62761261
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.62414556
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58397611
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58277029
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57030958
30	RNF2_27304074_Chip-Seq_NSC_Mouse	1.56610144
31	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.54305414
32	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.52577575
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50692788
34	REST_21632747_ChIP-Seq_MESCs_Mouse	1.49734764
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48860805
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.43876958
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43623730
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.43623730
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42923723
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42584605
41	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.41015488
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.40902384
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.40447560
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40447560
45	AR_25329375_ChIP-Seq_VCAP_Human	1.40252677
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39307284
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39307284
48	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.39063697
49	STAT3_23295773_ChIP-Seq_U87_Human	1.37844666
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.37072269
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36907620
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36087066
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36087066
54	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34524178
55	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.33566564
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32947668
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32921445
58	SMAD4_21799915_ChIP-Seq_A2780_Human	1.32377277
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32092914
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31804751
61	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.31700036
62	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.30069911
63	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.29396466
64	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.27040596
65	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26589444
66	TCF4_23295773_ChIP-Seq_U87_Human	1.25953259
67	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.25534887
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.24337401
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24010051
70	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.22364149
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22261007
72	NCOR_22424771_ChIP-Seq_293T_Human	1.20524723
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18313418
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17369424
75	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.16427213
76	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.16314579
77	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12981222
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12952646
79	AR_20517297_ChIP-Seq_VCAP_Human	1.12358979
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11861598
81	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.10817305
82	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.10683747
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10443669
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10072766
85	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.09305468
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08149932
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07371852
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06665545
89	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.05761435
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05699299
91	AR_21572438_ChIP-Seq_LNCaP_Human	1.05613666
92	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04894025
93	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.04328115
94	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02074310
95	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.00612154
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00084297
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99409849
98	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99247635
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.98948215
100	ERA_21632823_ChIP-Seq_H3396_Human	0.98444933

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	2.64662818
2	MP0002102_abnormal_ear_morphology	2.50374571
3	MP0008877_abnormal_DNA_methylation	2.46871721
4	MP0005551_abnormal_eye_electrophysiolog	2.41028742
5	MP0003787_abnormal_imprinting	2.34717050
6	MP0003136_yellow_coat_color	2.33866111
7	MP0004147_increased_porphyrin_level	2.30201161
8	MP0002653_abnormal_ependyma_morphology	2.24109082
9	MP0002837_dystrophic_cardiac_calcinosis	2.19225756
10	MP0006292_abnormal_olfactory_placode	2.17915145
11	MP0000569_abnormal_digit_pigmentation	2.17505101
12	MP0004885_abnormal_endolymph	2.08765394
13	MP0003880_abnormal_central_pattern	2.04991024
14	MP0001968_abnormal_touch/_nociception	2.04591925
15	MP0001485_abnormal_pinna_reflex	2.04347727
16	MP0006072_abnormal_retinal_apoptosis	1.99937572
17	MP0009046_muscle_twitch	1.95001195
18	MP0003011_delayed_dark_adaptation	1.93348391
19	MP0003646_muscle_fatigue	1.89981733
20	MP0002638_abnormal_pupillary_reflex	1.86689707
21	MP0009745_abnormal_behavioral_response	1.85749247
22	MP0004133_heterotaxia	1.84586367
23	MP0003283_abnormal_digestive_organ	1.83068259
24	MP0002938_white_spotting	1.82811648
25	MP0002736_abnormal_nociception_after	1.80326218
26	MP0005645_abnormal_hypothalamus_physiol	1.79601282
27	MP0008872_abnormal_physiological_respon	1.79417061
28	MP0004142_abnormal_muscle_tone	1.77559682
29	MP0005253_abnormal_eye_physiology	1.74481573
30	MP0002272_abnormal_nervous_system	1.74201253
31	MP0005646_abnormal_pituitary_gland	1.74114832
32	MP0001529_abnormal_vocalization	1.71082679
33	MP0005084_abnormal_gallbladder_morpholo	1.64884683
34	MP0002876_abnormal_thyroid_physiology	1.59439325
35	MP0008875_abnormal_xenobiotic_pharmacok	1.59152897
36	MP0000372_irregular_coat_pigmentation	1.56722633
37	MP0006276_abnormal_autonomic_nervous	1.56272165
38	MP0001986_abnormal_taste_sensitivity	1.54696177
39	MP0000631_abnormal_neuroendocrine_gland	1.49789436
40	MP0002735_abnormal_chemical_nociception	1.47771827
41	MP0001486_abnormal_startle_reflex	1.45997184
42	MP0001501_abnormal_sleep_pattern	1.43073674
43	MP0005174_abnormal_tail_pigmentation	1.42254975
44	MP0004742_abnormal_vestibular_system	1.41098136
45	MP0001984_abnormal_olfaction	1.40566204
46	MP0002572_abnormal_emotion/affect_behav	1.40490265
47	MP0000427_abnormal_hair_cycle	1.38517028
48	MP0002557_abnormal_social/conspecific_i	1.36203909
49	MP0002064_seizures	1.32721198
50	MP0001970_abnormal_pain_threshold	1.31935832
51	MP0004043_abnormal_pH_regulation	1.31859924
52	MP0003122_maternal_imprinting	1.30355120
53	MP0002733_abnormal_thermal_nociception	1.27143034
54	MP0003890_abnormal_embryonic-extraembry	1.26391546
55	MP0005386_behavior/neurological_phenoty	1.23714307
56	MP0004924_abnormal_behavior	1.23714307
57	MP0002751_abnormal_autonomic_nervous	1.23560103
58	MP0002277_abnormal_respiratory_mucosa	1.21496143
59	MP0003121_genomic_imprinting	1.20358323
60	MP0002928_abnormal_bile_duct	1.19343536
61	MP0000778_abnormal_nervous_system	1.16291606
62	MP0008789_abnormal_olfactory_epithelium	1.16117500
63	MP0005195_abnormal_posterior_eye	1.14774615
64	MP0002067_abnormal_sensory_capabilities	1.13933308
65	MP0003878_abnormal_ear_physiology	1.13057046
66	MP0005377_hearing/vestibular/ear_phenot	1.13057046
67	MP0005389_reproductive_system_phenotype	1.12637159
68	MP0003635_abnormal_synaptic_transmissio	1.10625420
69	MP0008995_early_reproductive_senescence	1.10031341
70	MP0002063_abnormal_learning/memory/cond	1.08263403
71	MP0002160_abnormal_reproductive_system	1.06762503
72	MP0002734_abnormal_mechanical_nocicepti	1.01987932
73	MP0002163_abnormal_gland_morphology	1.00818450
74	MP0010386_abnormal_urinary_bladder	0.99736828
75	MP0000026_abnormal_inner_ear	0.98124977
76	MP0002095_abnormal_skin_pigmentation	0.96888985
77	MP0001905_abnormal_dopamine_level	0.96691049
78	MP0002752_abnormal_somatic_nervous	0.95617566
79	MP0003119_abnormal_digestive_system	0.94981292
80	MP0000647_abnormal_sebaceous_gland	0.92273549
81	MP0001919_abnormal_reproductive_system	0.92116083
82	MP0003137_abnormal_impulse_conducting	0.90583528
83	MP0004145_abnormal_muscle_electrophysio	0.90375992
84	MP0005379_endocrine/exocrine_gland_phen	0.89757822
85	MP0001293_anophthalmia	0.89087697
86	MP0005394_taste/olfaction_phenotype	0.88895316
87	MP0005499_abnormal_olfactory_system	0.88895316
88	MP0005423_abnormal_somatic_nervous	0.87012355
89	MP0000230_abnormal_systemic_arterial	0.86830534
90	MP0001502_abnormal_circadian_rhythm	0.86390082
91	MP0008775_abnormal_heart_ventricle	0.86063638
92	MP0001440_abnormal_grooming_behavior	0.83454637
93	MP0004215_abnormal_myocardial_fiber	0.83418657
94	MP0005167_abnormal_blood-brain_barrier	0.83415994
95	MP0005410_abnormal_fertilization	0.82594109
96	MP0002229_neurodegeneration	0.82281437
97	MP0002184_abnormal_innervation	0.81624115
98	MP0001963_abnormal_hearing_physiology	0.80775496
99	MP0002234_abnormal_pharynx_morphology	0.80447467
100	MP0002909_abnormal_adrenal_gland	0.78531497

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.30663755
2	Molar tooth sign on MRI (HP:0002419)	4.30663755
3	Pancreatic cysts (HP:0001737)	4.25191330
4	Pancreatic fibrosis (HP:0100732)	4.05188279
5	True hermaphroditism (HP:0010459)	3.97079834
6	Congenital stationary night blindness (HP:0007642)	3.78860294
7	Nephronophthisis (HP:0000090)	3.69606320
8	Type II lissencephaly (HP:0007260)	3.50836667
9	Medial flaring of the eyebrow (HP:0010747)	3.24840448
10	Abnormality of the renal medulla (HP:0100957)	3.24158836
11	Abnormality of the renal cortex (HP:0011035)	3.21919228
12	Hyperventilation (HP:0002883)	3.17590307
13	Abolished electroretinogram (ERG) (HP:0000550)	2.87864213
14	Tubular atrophy (HP:0000092)	2.76806246
15	Attenuation of retinal blood vessels (HP:0007843)	2.76232446
16	Abnormal drinking behavior (HP:0030082)	2.67220681
17	Polydipsia (HP:0001959)	2.67220681
18	Chronic hepatic failure (HP:0100626)	2.63888709
19	Gait imbalance (HP:0002141)	2.62877463
20	Cystic liver disease (HP:0006706)	2.62051646
21	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.60535209
22	Absent/shortened dynein arms (HP:0200106)	2.60535209
23	Large for gestational age (HP:0001520)	2.60494508
24	Congenital primary aphakia (HP:0007707)	2.56971496
25	Pendular nystagmus (HP:0012043)	2.54311902
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.50833965
27	Abnormal respiratory epithelium morphology (HP:0012253)	2.47570144
28	Abnormal respiratory motile cilium morphology (HP:0005938)	2.47570144
29	Birth length less than 3rd percentile (HP:0003561)	2.47206140
30	Lissencephaly (HP:0001339)	2.45457483
31	Inability to walk (HP:0002540)	2.42107838
32	Sclerocornea (HP:0000647)	2.41605329
33	Progressive inability to walk (HP:0002505)	2.38849120
34	Keratoconus (HP:0000563)	2.37268861
35	Increased corneal curvature (HP:0100692)	2.37268861
36	Congenital, generalized hypertrichosis (HP:0004540)	2.37100348
37	Decreased central vision (HP:0007663)	2.34239986
38	Methylmalonic acidemia (HP:0002912)	2.33391979
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.31005893
40	Abnormality of alanine metabolism (HP:0010916)	2.30168107
41	Hyperalaninemia (HP:0003348)	2.30168107
42	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.30168107
43	Nephrogenic diabetes insipidus (HP:0009806)	2.28978308
44	Retinal dysplasia (HP:0007973)	2.28745087
45	Renal cortical cysts (HP:0000803)	2.28696875
46	Abnormal biliary tract physiology (HP:0012439)	2.24174628
47	Bile duct proliferation (HP:0001408)	2.24174628
48	Decreased circulating renin level (HP:0003351)	2.24062209
49	Anencephaly (HP:0002323)	2.21524841
50	Polyuria (HP:0000103)	2.20121293
51	Concave nail (HP:0001598)	2.19863343
52	Abnormality of the pons (HP:0007361)	2.19231671
53	Hypoplasia of the pons (HP:0012110)	2.12745048
54	Genital tract atresia (HP:0001827)	2.12326836
55	Patellar aplasia (HP:0006443)	2.11296798
56	Furrowed tongue (HP:0000221)	2.11030217
57	Vaginal atresia (HP:0000148)	2.10851443
58	Cerebellar dysplasia (HP:0007033)	2.09850579
59	Acute necrotizing encephalopathy (HP:0006965)	2.07017277
60	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.06613676
61	Optic nerve hypoplasia (HP:0000609)	2.06089338
62	Congenital hepatic fibrosis (HP:0002612)	2.04311086
63	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.01857004
64	Abnormal ciliary motility (HP:0012262)	2.01138163
65	Aplasia/Hypoplasia of the patella (HP:0006498)	2.00948160
66	Hypothermia (HP:0002045)	2.00298811
67	3-Methylglutaconic aciduria (HP:0003535)	2.00258886
68	Male pseudohermaphroditism (HP:0000037)	2.00131225
69	Hemiparesis (HP:0001269)	1.98948804
70	Mitochondrial inheritance (HP:0001427)	1.98495017
71	Methylmalonic aciduria (HP:0012120)	1.98480299
72	Severe muscular hypotonia (HP:0006829)	1.98331759
73	Increased hepatocellular lipid droplets (HP:0006565)	1.98069788
74	Lipid accumulation in hepatocytes (HP:0006561)	1.98057226
75	Broad-based gait (HP:0002136)	1.97444812
76	Chorioretinal atrophy (HP:0000533)	1.94973277
77	Postaxial foot polydactyly (HP:0001830)	1.94411014
78	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.93905094
79	Bony spicule pigmentary retinopathy (HP:0007737)	1.93650038
80	Abnormality of the labia minora (HP:0012880)	1.93638831
81	Progressive cerebellar ataxia (HP:0002073)	1.93220853
82	Stomach cancer (HP:0012126)	1.92719577
83	Gaze-evoked nystagmus (HP:0000640)	1.92353707
84	Progressive macrocephaly (HP:0004481)	1.90821223
85	Optic disc pallor (HP:0000543)	1.90139657
86	Increased CSF lactate (HP:0002490)	1.85400688
87	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.85399973
88	Acute encephalopathy (HP:0006846)	1.84013492
89	Pachygyria (HP:0001302)	1.81435881
90	Bilateral microphthalmos (HP:0007633)	1.80378839
91	Protruding tongue (HP:0010808)	1.80203428
92	Ketosis (HP:0001946)	1.79607935
93	Tachypnea (HP:0002789)	1.77937100
94	Rib fusion (HP:0000902)	1.77660826
95	Postaxial hand polydactyly (HP:0001162)	1.77570530
96	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.77542971
97	Genetic anticipation (HP:0003743)	1.76230426
98	Agitation (HP:0000713)	1.76187228
99	Abnormal urine output (HP:0012590)	1.75965435
100	Polyphagia (HP:0002591)	1.73884196

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.44855694
2	ACVR1B	3.33142247
3	ADRBK2	3.31309145
4	BMPR1B	3.20430668
5	TLK1	2.86692108
6	ZAK	2.75032830
7	WNK4	2.73362597
8	WNK3	2.71952450
9	CASK	2.47653497
10	GRK1	2.34981558
11	PINK1	2.19632977
12	MAP4K2	2.08089028
13	NUAK1	2.00623059
14	MAP3K4	1.96065031
15	DAPK2	1.85768023
16	TNIK	1.76062353
17	INSRR	1.65289507
18	PNCK	1.60246384
19	STK39	1.59060041
20	TAOK3	1.58213895
21	MAP2K7	1.55650220
22	MAPK13	1.50772458
23	MAPK15	1.46000877
24	CAMKK2	1.45886578
25	TXK	1.44408549
26	OXSR1	1.31894911
27	MKNK2	1.21102161
28	ADRBK1	1.15418451
29	TGFBR1	1.15270312
30	VRK1	1.10827198
31	MARK1	1.10524902
32	PAK3	1.08839072
33	BCKDK	1.07969295
34	PRKCG	1.06311520
35	DYRK2	1.05015979
36	TRIM28	1.02899238
37	PRKCE	1.02736993
38	PHKG2	0.97524438
39	PHKG1	0.97524438
40	NTRK2	0.95082869
41	CSNK1G2	0.92333819
42	MAP2K6	0.90646670
43	FGFR2	0.90368529
44	NME1	0.80562824
45	CAMK1D	0.77990620
46	TIE1	0.77349127
47	MUSK	0.77144201
48	STK16	0.75894449
49	CSNK1G1	0.75692943
50	PLK2	0.74855907
51	TEC	0.73557085
52	TSSK6	0.71765623
53	KIT	0.70324235
54	PIK3CA	0.69056533
55	CSNK1G3	0.68912253
56	PLK3	0.68866829
57	BCR	0.68828024
58	ERBB3	0.66239405
59	EPHA4	0.64344168
60	PTK2B	0.62285095
61	CAMK2A	0.61587087
62	MKNK1	0.60866588
63	PRKCI	0.60680195
64	NEK1	0.57718439
65	RPS6KA5	0.56520998
66	CAMKK1	0.56231587
67	PRKCQ	0.55416752
68	CAMK1	0.53354756
69	STK38L	0.52911222
70	MST4	0.52161254
71	NEK2	0.52113029
72	TAF1	0.51621006
73	CAMK1G	0.50282839
74	EPHA3	0.49477692
75	WEE1	0.49290993
76	CSNK1A1L	0.49242850
77	NTRK3	0.48662891
78	PRKACA	0.47899951
79	IKBKB	0.47719832
80	MAP2K4	0.46809338
81	GRK7	0.44874827
82	MAPKAPK3	0.43693057
83	CSNK1A1	0.42349908
84	IRAK1	0.42141265
85	PKN1	0.40833343
86	OBSCN	0.40487153
87	FLT3	0.39028997
88	ITK	0.38415506
89	PLK1	0.38090408
90	PRKCZ	0.36379313
91	STK11	0.36297080
92	PLK4	0.35242157
93	PRKCA	0.35158006
94	ERBB2	0.34877132
95	CHUK	0.34189404
96	DYRK3	0.33907329
97	NLK	0.29924499
98	GRK5	0.29608154
99	CDK3	0.28129438
100	VRK2	0.27750409

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	2.79879789
2	Phototransduction_Homo sapiens_hsa04744	2.65176798
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.55288584
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.51093899
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.38145393
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.34578138
7	Protein export_Homo sapiens_hsa03060	2.31835849
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.18736198
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18226838
10	Nicotine addiction_Homo sapiens_hsa05033	2.13245580
11	Parkinsons disease_Homo sapiens_hsa05012	2.10833467
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.00312126
13	Butanoate metabolism_Homo sapiens_hsa00650	2.00036984
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.97066008
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.91931831
16	Caffeine metabolism_Homo sapiens_hsa00232	1.89354890
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.88961272
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.88011528
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.82394622
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.73556039
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.67899377
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.59479720
23	Homologous recombination_Homo sapiens_hsa03440	1.58624463
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.57374901
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.50087148
26	RNA polymerase_Homo sapiens_hsa03020	1.44110657
27	Huntingtons disease_Homo sapiens_hsa05016	1.42565600
28	Taste transduction_Homo sapiens_hsa04742	1.40936041
29	Propanoate metabolism_Homo sapiens_hsa00640	1.38487275
30	Alzheimers disease_Homo sapiens_hsa05010	1.37344692
31	Olfactory transduction_Homo sapiens_hsa04740	1.36157221
32	Basal transcription factors_Homo sapiens_hsa03022	1.35926019
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32792808
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.32758780
35	Morphine addiction_Homo sapiens_hsa05032	1.21589203
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15763087
37	Peroxisome_Homo sapiens_hsa04146	1.15342908
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.15131000
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.06021792
40	GABAergic synapse_Homo sapiens_hsa04727	1.03641037
41	Insulin secretion_Homo sapiens_hsa04911	1.03412504
42	RNA degradation_Homo sapiens_hsa03018	1.02341474
43	ABC transporters_Homo sapiens_hsa02010	1.00714865
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99850661
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.98018487
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.97707753
47	One carbon pool by folate_Homo sapiens_hsa00670	0.96352360
48	Sulfur relay system_Homo sapiens_hsa04122	0.95830881
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.95150012
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.94370986
51	Retinol metabolism_Homo sapiens_hsa00830	0.93410389
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92412803
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91449991
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91103498
55	Serotonergic synapse_Homo sapiens_hsa04726	0.91070625
56	Regulation of autophagy_Homo sapiens_hsa04140	0.89971510
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.88152057
58	Ribosome_Homo sapiens_hsa03010	0.84409641
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83534225
60	Circadian entrainment_Homo sapiens_hsa04713	0.83254294
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80728070
62	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.73381280
63	Asthma_Homo sapiens_hsa05310	0.72730567
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71406623
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.71008228
66	Histidine metabolism_Homo sapiens_hsa00340	0.68919705
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67449105
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.66245171
69	Proteasome_Homo sapiens_hsa03050	0.65817098
70	Salivary secretion_Homo sapiens_hsa04970	0.64755160
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62531041
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.61446282
73	Metabolic pathways_Homo sapiens_hsa01100	0.60977362
74	Purine metabolism_Homo sapiens_hsa00230	0.59706977
75	Dopaminergic synapse_Homo sapiens_hsa04728	0.56748050
76	Type I diabetes mellitus_Homo sapiens_hsa04940	0.55700266
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.54891027
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.54577009
79	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.53461840
80	Graft-versus-host disease_Homo sapiens_hsa05332	0.52902528
81	Mineral absorption_Homo sapiens_hsa04978	0.51371522
82	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.50253224
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.47932977
84	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.46533513
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.45756859
86	Amphetamine addiction_Homo sapiens_hsa05031	0.44142476
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.43454403
88	Cocaine addiction_Homo sapiens_hsa05030	0.43377871
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41830909
90	Long-term depression_Homo sapiens_hsa04730	0.41669129
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41080565
92	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.40200295
93	Fatty acid elongation_Homo sapiens_hsa00062	0.38137183
94	Tyrosine metabolism_Homo sapiens_hsa00350	0.37286664
95	Sulfur metabolism_Homo sapiens_hsa00920	0.37016233
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36273283
97	Non-homologous end-joining_Homo sapiens_hsa03450	0.36025823
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.35924435
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.35521193
100	Circadian rhythm_Homo sapiens_hsa04710	0.35313461

TCEB1P33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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