TCEB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.52336239
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.08558752
3ATP synthesis coupled proton transport (GO:0015986)8.08558752
4ribosomal small subunit biogenesis (GO:0042274)7.30747634
5viral transcription (GO:0019083)7.30514808
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.15854457
7translational termination (GO:0006415)7.01286330
8ribosomal small subunit assembly (GO:0000028)6.47298565
9respiratory electron transport chain (GO:0022904)6.39423194
10electron transport chain (GO:0022900)6.23811496
11cotranslational protein targeting to membrane (GO:0006613)6.17889109
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.16806963
13protein targeting to ER (GO:0045047)6.10725120
14establishment of protein localization to endoplasmic reticulum (GO:0072599)5.82360883
15* translational elongation (GO:0006414)5.80152176
16protein localization to endoplasmic reticulum (GO:0070972)5.78737359
17protein neddylation (GO:0045116)5.77492020
18cellular protein complex disassembly (GO:0043624)5.71976123
19viral life cycle (GO:0019058)5.62554651
20maturation of SSU-rRNA (GO:0030490)5.46610499
21establishment of protein localization to mitochondrial membrane (GO:0090151)5.25767140
22chaperone-mediated protein transport (GO:0072321)5.22429500
23translational initiation (GO:0006413)5.17710301
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.15568792
25ribosomal large subunit biogenesis (GO:0042273)5.01786278
26proteasome assembly (GO:0043248)5.00780749
27protein complex disassembly (GO:0043241)4.88394589
28GTP biosynthetic process (GO:0006183)4.76876314
29translation (GO:0006412)4.68716843
30macromolecular complex disassembly (GO:0032984)4.66267491
31protein complex biogenesis (GO:0070271)4.54635621
32sequestering of actin monomers (GO:0042989)4.45609538
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.38795503
34mitochondrial respiratory chain complex I assembly (GO:0032981)4.38795503
35NADH dehydrogenase complex assembly (GO:0010257)4.38795503
36purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.23086435
37UTP biosynthetic process (GO:0006228)4.22120021
38mitochondrial respiratory chain complex assembly (GO:0033108)4.20399690
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.16307943
40purine nucleoside triphosphate biosynthetic process (GO:0009145)4.11980668
41protein targeting to membrane (GO:0006612)4.11841313
42transcription elongation from RNA polymerase III promoter (GO:0006385)4.10262994
43termination of RNA polymerase III transcription (GO:0006386)4.10262994
44ATP biosynthetic process (GO:0006754)4.07717898
45hydrogen ion transmembrane transport (GO:1902600)4.04058253
46establishment of integrated proviral latency (GO:0075713)4.02087904
47regulation of mitochondrial translation (GO:0070129)3.95202894
48regulation of cellular amino acid metabolic process (GO:0006521)3.93061781
49negative regulation of ligase activity (GO:0051352)3.92161603
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.92161603
51establishment of protein localization to mitochondrion (GO:0072655)3.91977248
52protein targeting to mitochondrion (GO:0006626)3.86064731
53cullin deneddylation (GO:0010388)3.82239354
54guanosine-containing compound biosynthetic process (GO:1901070)3.80110583
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.77134490
56ribonucleoside triphosphate biosynthetic process (GO:0009201)3.76181674
57cytochrome complex assembly (GO:0017004)3.74726737
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.74201688
597-methylguanosine mRNA capping (GO:0006370)3.69893281
60ribonucleoprotein complex biogenesis (GO:0022613)3.67637007
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.67030338
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.67030338
63establishment of viral latency (GO:0019043)3.63772163
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.63551301
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.63551301
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.63551301
677-methylguanosine RNA capping (GO:0009452)3.62945197
68RNA capping (GO:0036260)3.62945197
69cellular component biogenesis (GO:0044085)3.61469494
70protein localization to mitochondrion (GO:0070585)3.61082489
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.59199513
72signal transduction involved in DNA damage checkpoint (GO:0072422)3.58151310
73signal transduction involved in DNA integrity checkpoint (GO:0072401)3.58151310
74UTP metabolic process (GO:0046051)3.56585240
75respiratory chain complex IV assembly (GO:0008535)3.55721368
76signal transduction involved in cell cycle checkpoint (GO:0072395)3.54631007
77DNA deamination (GO:0045006)3.54460301
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.53778802
79nuclear-transcribed mRNA catabolic process (GO:0000956)3.50450652
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48891472
81proton transport (GO:0015992)3.44685041
82protein deneddylation (GO:0000338)3.43189741
83deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40717383
84DNA damage response, detection of DNA damage (GO:0042769)3.37568608
85oxidative phosphorylation (GO:0006119)3.34803206
86pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.34233069
87hydrogen transport (GO:0006818)3.34172747
88CTP biosynthetic process (GO:0006241)3.33171443
89CTP metabolic process (GO:0046036)3.33171443
90nucleoside triphosphate biosynthetic process (GO:0009142)3.29504445
91mRNA catabolic process (GO:0006402)3.28537099
92antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.28449371
93spliceosomal snRNP assembly (GO:0000387)3.26970891
94rRNA modification (GO:0000154)3.23861445
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23357715
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23357715
97intracellular protein transmembrane import (GO:0044743)3.23264701
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19520214
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18298172
100spliceosomal complex assembly (GO:0000245)3.16318770
101inner mitochondrial membrane organization (GO:0007007)3.13048808
102establishment of protein localization to membrane (GO:0090150)3.11835812
103protein-cofactor linkage (GO:0018065)3.11445147
104regulation of cellular amine metabolic process (GO:0033238)3.11302946
105purine nucleoside monophosphate biosynthetic process (GO:0009127)3.10796613
106purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.10796613
107rRNA processing (GO:0006364)3.09098647
108positive regulation of ligase activity (GO:0051351)3.08414817
109pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.07107802
110exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07054864
111protein targeting (GO:0006605)3.05303939
112water-soluble vitamin biosynthetic process (GO:0042364)3.04480509
113pseudouridine synthesis (GO:0001522)3.02736611
114pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.02597152
115mitochondrial transport (GO:0006839)3.01987830
116establishment of protein localization to organelle (GO:0072594)3.01501510
117rRNA metabolic process (GO:0016072)2.97207633
118RNA catabolic process (GO:0006401)2.96475794
119base-excision repair, AP site formation (GO:0006285)2.90710951
120aerobic respiration (GO:0009060)2.86122073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.58869862
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.52417838
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.30461459
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.13986539
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.01313893
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.82993290
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.76165949
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.49511295
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.40357390
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.38877966
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34764980
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.33743030
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.28981928
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.25968784
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.10568587
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94247887
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93406870
18XRN2_22483619_ChIP-Seq_HELA_Human2.55219676
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47002073
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38567658
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36293986
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.27727739
23* DCP1A_22483619_ChIP-Seq_HELA_Human2.26663424
24VDR_23849224_ChIP-Seq_CD4+_Human2.23251440
25TTF2_22483619_ChIP-Seq_HELA_Human2.21090741
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16059698
27ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.14852722
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.14392167
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.92175173
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89350628
31ELK1_19687146_ChIP-ChIP_HELA_Human1.85140538
32ELK1_22589737_ChIP-Seq_MCF10A_Human1.82839361
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73571628
34FOXP3_21729870_ChIP-Seq_TREG_Human1.73137228
35GABP_19822575_ChIP-Seq_HepG2_Human1.65081280
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63929562
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63335069
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62468889
39* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.58007043
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51689111
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49952967
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48259996
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43384738
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38082843
45MYC_18940864_ChIP-ChIP_HL60_Human1.37376089
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34919845
47* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.34653416
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32351211
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31946852
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25405514
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24448170
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24065434
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22661952
54VDR_22108803_ChIP-Seq_LS180_Human1.21957919
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21267719
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20620813
57OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16589560
58ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14468581
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12784537
60SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11738869
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08794986
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08211032
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06752703
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06068702
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05031124
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04169188
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03095816
68SOX17_20123909_ChIP-Seq_XEN_Mouse1.02549243
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02522182
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02024570
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01782041
72* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00331213
73YY1_22570637_ChIP-Seq_MALME-3M_Human0.99595196
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99249739
75POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97804838
76SOX2_16153702_ChIP-ChIP_HESCs_Human0.97191310
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97173472
78PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96402403
79EZH2_22144423_ChIP-Seq_EOC_Human0.95599258
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95249013
81IRF1_19129219_ChIP-ChIP_H3396_Human0.95048171
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94749535
83MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94726277
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94524636
85TET1_21451524_ChIP-Seq_MESCs_Mouse0.93942403
86STAT1_20625510_ChIP-Seq_HELA_Human0.92624680
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90105087
88ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89510529
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88914515
90KDM5A_27292631_Chip-Seq_BREAST_Human0.88501248
91ZNF274_21170338_ChIP-Seq_K562_Hela0.86648185
92TP53_22573176_ChIP-Seq_HFKS_Human0.86613719
93* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84903097
94NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84287287
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84209597
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83775431
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.83329615
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83266084
99* CTCF_26484167_Chip-Seq_Bcells_Mouse0.81931288
100ERG_20517297_ChIP-Seq_VCAP_Human0.81015901
101BP1_19119308_ChIP-ChIP_Hs578T_Human0.80215991
102* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79487480
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79392526
104PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79343465
105FOXP1_21924763_ChIP-Seq_HESCs_Human0.79195592
106* CTCF_20526341_ChIP-Seq_ESCs_Human0.78239934
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77124975
108NANOG_16153702_ChIP-ChIP_HESCs_Human0.76433051
109ERA_21632823_ChIP-Seq_H3396_Human0.75994275
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75904557
111EZH2_27304074_Chip-Seq_ESCs_Mouse0.74589296
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73496301
113KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.73496301
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73496301
115SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.72635172
116PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72339633
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71573358
118CBX2_27304074_Chip-Seq_ESCs_Mouse0.71349496
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70645473
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.70633987
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.70399532
122NANOG_20526341_ChIP-Seq_ESCs_Human0.69979152
123TAF2_19829295_ChIP-Seq_ESCs_Human0.69962138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.59719181
2MP0001529_abnormal_vocalization3.90171718
3MP0003880_abnormal_central_pattern3.24604246
4MP0006276_abnormal_autonomic_nervous2.98828833
5MP0001905_abnormal_dopamine_level2.91979536
6MP0003136_yellow_coat_color2.84612427
7MP0004957_abnormal_blastocyst_morpholog2.10307871
8MP0002638_abnormal_pupillary_reflex2.04449757
9MP0008932_abnormal_embryonic_tissue2.04212065
10MP0002163_abnormal_gland_morphology2.03736789
11MP0002736_abnormal_nociception_after1.99378822
12MP0000566_synostosis1.95382840
13MP0001968_abnormal_touch/_nociception1.87593207
14MP0002102_abnormal_ear_morphology1.81894397
15MP0003693_abnormal_embryo_hatching1.80093485
16MP0002277_abnormal_respiratory_mucosa1.79898365
17MP0000372_irregular_coat_pigmentation1.79777444
18MP0005410_abnormal_fertilization1.77830717
19MP0002938_white_spotting1.76987123
20MP0003315_abnormal_perineum_morphology1.72364285
21MP0004142_abnormal_muscle_tone1.69229621
22MP0001188_hyperpigmentation1.69101474
23MP0002751_abnormal_autonomic_nervous1.66920883
24MP0004133_heterotaxia1.63717267
25MP0006036_abnormal_mitochondrial_physio1.58872801
26MP0006035_abnormal_mitochondrial_morpho1.57361384
27MP0008789_abnormal_olfactory_epithelium1.51124513
28MP0005084_abnormal_gallbladder_morpholo1.50198873
29MP0003186_abnormal_redox_activity1.46248888
30MP0010030_abnormal_orbit_morphology1.45770235
31MP0002234_abnormal_pharynx_morphology1.44068531
32MP0003786_premature_aging1.43850909
33MP0001485_abnormal_pinna_reflex1.43069022
34MP0008995_early_reproductive_senescence1.42487240
35MP0002735_abnormal_chemical_nociception1.41885361
36MP0002734_abnormal_mechanical_nocicepti1.41134050
37MP0005409_darkened_coat_color1.35027203
38MP0001727_abnormal_embryo_implantation1.34631068
39MP0001293_anophthalmia1.34544120
40MP0003718_maternal_effect1.34422142
41MP0005423_abnormal_somatic_nervous1.34076520
42MP0001440_abnormal_grooming_behavior1.32626078
43MP0001986_abnormal_taste_sensitivity1.29573394
44MP0000049_abnormal_middle_ear1.29534064
45MP0001970_abnormal_pain_threshold1.29464501
46MP0006072_abnormal_retinal_apoptosis1.28035489
47MP0003122_maternal_imprinting1.27260572
48MP0000631_abnormal_neuroendocrine_gland1.26753046
49MP0003123_paternal_imprinting1.24650294
50MP0004742_abnormal_vestibular_system1.24308720
51MP0003938_abnormal_ear_development1.24120706
52MP0000778_abnormal_nervous_system1.23343256
53MP0002272_abnormal_nervous_system1.22765877
54MP0002653_abnormal_ependyma_morphology1.22521272
55MP0005551_abnormal_eye_electrophysiolog1.22258128
56MP0005171_absent_coat_pigmentation1.21611905
57MP0006292_abnormal_olfactory_placode1.21182258
58MP0002733_abnormal_thermal_nociception1.19758707
59MP0002095_abnormal_skin_pigmentation1.17918011
60MP0003283_abnormal_digestive_organ1.17879067
61MP0002132_abnormal_respiratory_system1.16933731
62MP0008875_abnormal_xenobiotic_pharmacok1.11373574
63MP0010386_abnormal_urinary_bladder1.10464602
64MP0003077_abnormal_cell_cycle1.08838358
65MP0005499_abnormal_olfactory_system1.08264777
66MP0005394_taste/olfaction_phenotype1.08264777
67MP0002160_abnormal_reproductive_system1.06857762
68MP0005253_abnormal_eye_physiology1.04263399
69MP0000026_abnormal_inner_ear1.04078675
70MP0004147_increased_porphyrin_level1.02020127
71MP0008058_abnormal_DNA_repair1.01797244
72MP0002184_abnormal_innervation1.01351432
73MP0005379_endocrine/exocrine_gland_phen1.00513606
74MP0005646_abnormal_pituitary_gland0.96963565
75MP0002332_abnormal_exercise_endurance0.96789362
76MP0005389_reproductive_system_phenotype0.96736293
77MP0001919_abnormal_reproductive_system0.96056900
78MP0001346_abnormal_lacrimal_gland0.95749089
79MP0002752_abnormal_somatic_nervous0.95268337
80MP0000750_abnormal_muscle_regeneration0.94455358
81MP0000749_muscle_degeneration0.92489111
82MP0002064_seizures0.91445155
83MP0000762_abnormal_tongue_morphology0.91407731
84MP0003646_muscle_fatigue0.91308422
85MP0001764_abnormal_homeostasis0.91187997
86MP0005377_hearing/vestibular/ear_phenot0.91173897
87MP0003878_abnormal_ear_physiology0.91173897
88MP0009046_muscle_twitch0.91076064
89MP0003806_abnormal_nucleotide_metabolis0.91054971
90MP0009745_abnormal_behavioral_response0.90901474
91MP0000538_abnormal_urinary_bladder0.90831944
92MP0003121_genomic_imprinting0.88471055
93MP0002572_abnormal_emotion/affect_behav0.88064799
94MP0005195_abnormal_posterior_eye0.87499708
95MP0004381_abnormal_hair_follicle0.87309070
96MP0002282_abnormal_trachea_morphology0.86224220
97MP0002837_dystrophic_cardiac_calcinosis0.85987523
98MP0003011_delayed_dark_adaptation0.85283159
99MP0005408_hypopigmentation0.85139263
100MP0002557_abnormal_social/conspecific_i0.84071357
101MP0002210_abnormal_sex_determination0.83975914
102MP0000462_abnormal_digestive_system0.83640874
103MP0002822_catalepsy0.82093603
104MP0004019_abnormal_vitamin_homeostasis0.81581080
105MP0005386_behavior/neurological_phenoty0.80829090
106MP0004924_abnormal_behavior0.80829090
107MP0003111_abnormal_nucleus_morphology0.80713823
108MP0008872_abnormal_physiological_respon0.80619304
109MP0002067_abnormal_sensory_capabilities0.79559153
110MP0004885_abnormal_endolymph0.77661942
111MP0001542_abnormal_bone_strength0.77611655
112MP0000358_abnormal_cell_content/0.77523778
113MP0005645_abnormal_hypothalamus_physiol0.77395995
114MP0003941_abnormal_skin_development0.77113981
115MP0001963_abnormal_hearing_physiology0.76754476
116MP0003137_abnormal_impulse_conducting0.76465581
117MP0009250_abnormal_appendicular_skeleto0.75890631
118MP0003698_abnormal_male_reproductive0.75658461
119MP0001984_abnormal_olfaction0.75548308
120MP0004270_analgesia0.73815897
121MP0001664_abnormal_digestion0.73808554
122MP0008877_abnormal_DNA_methylation0.71456581
123MP0002882_abnormal_neuron_morphology0.71289950
124MP0004145_abnormal_muscle_electrophysio0.70871127
125MP0005332_abnormal_amino_acid0.70579180
126MP0005503_abnormal_tendon_morphology0.69396129
127MP0005391_vision/eye_phenotype0.68234834

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.12157206
2Mitochondrial inheritance (HP:0001427)6.31579087
3Abnormal mitochondria in muscle tissue (HP:0008316)6.29416342
4Progressive macrocephaly (HP:0004481)5.95012737
5Abnormality of cells of the erythroid lineage (HP:0012130)5.69903475
6Acute encephalopathy (HP:0006846)5.59401641
7Increased CSF lactate (HP:0002490)5.17599711
8Hepatocellular necrosis (HP:0001404)5.13990587
9Increased hepatocellular lipid droplets (HP:0006565)5.08426466
10Abnormal number of erythroid precursors (HP:0012131)4.91232779
11Renal Fanconi syndrome (HP:0001994)4.55000495
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.44615951
13Reticulocytopenia (HP:0001896)4.42433496
14Lipid accumulation in hepatocytes (HP:0006561)4.37199853
15Hepatic necrosis (HP:0002605)4.18024405
16Macrocytic anemia (HP:0001972)4.10682336
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.08205727
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.97686093
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.97686093
203-Methylglutaconic aciduria (HP:0003535)3.94134515
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.90136503
22Exercise intolerance (HP:0003546)3.76088901
23Optic disc pallor (HP:0000543)3.72966651
24Respiratory failure (HP:0002878)3.67473020
25Cerebral edema (HP:0002181)3.62614465
26Leukodystrophy (HP:0002415)3.57735089
27Abnormality of glycolysis (HP:0004366)3.56614546
28Increased serum pyruvate (HP:0003542)3.56614546
29Increased intramyocellular lipid droplets (HP:0012240)3.50873414
30Exertional dyspnea (HP:0002875)3.46102704
31Pallor (HP:0000980)3.44478366
32Increased serum lactate (HP:0002151)3.29297678
33Lactic acidosis (HP:0003128)3.17566073
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.88791204
35Abnormality of renal resorption (HP:0011038)2.87954167
36Increased muscle lipid content (HP:0009058)2.80665393
37Congenital ichthyosiform erythroderma (HP:0007431)2.77079759
38Respiratory difficulties (HP:0002880)2.76539432
39Cerebral hypomyelination (HP:0006808)2.70157120
40Parakeratosis (HP:0001036)2.68375686
41Abnormality of placental membranes (HP:0011409)2.61167704
42Amniotic constriction ring (HP:0009775)2.61167704
43Septo-optic dysplasia (HP:0100842)2.45905459
44Emotional lability (HP:0000712)2.44734440
45Generalized aminoaciduria (HP:0002909)2.44224111
46Pancreatic fibrosis (HP:0100732)2.34385587
47Myokymia (HP:0002411)2.32783916
48Abnormality of midbrain morphology (HP:0002418)2.28418186
49Molar tooth sign on MRI (HP:0002419)2.28418186
50Hyperphosphaturia (HP:0003109)2.27333181
51Methylmalonic aciduria (HP:0012120)2.23820464
52Pancreatic cysts (HP:0001737)2.22757110
53Abnormal hemoglobin (HP:0011902)2.21497670
54CNS demyelination (HP:0007305)2.21336979
55Colon cancer (HP:0003003)2.17502967
56Microvesicular hepatic steatosis (HP:0001414)2.17456804
57Limb dystonia (HP:0002451)2.16086991
58X-linked dominant inheritance (HP:0001423)2.10971529
59Stenosis of the external auditory canal (HP:0000402)2.09767321
60True hermaphroditism (HP:0010459)2.09682355
61Trismus (HP:0000211)2.09102685
62Methylmalonic acidemia (HP:0002912)2.06864130
63Aplasia/hypoplasia of the uterus (HP:0008684)2.03126980
64Concave nail (HP:0001598)1.90736850
65Delusions (HP:0000746)1.90223582
66Breast hypoplasia (HP:0003187)1.90004803
67Rough bone trabeculation (HP:0100670)1.88252195
68Absent septum pellucidum (HP:0001331)1.87286004
69Abnormal respiratory motile cilium physiology (HP:0012261)1.87231975
70Carpal bone hypoplasia (HP:0001498)1.85776239
71Abnormal pupillary function (HP:0007686)1.85284946
72Abnormal urine phosphate concentration (HP:0012599)1.83538112
73Rib fusion (HP:0000902)1.83361074
74Nephronophthisis (HP:0000090)1.82635610
75Oral leukoplakia (HP:0002745)1.81174430
76Blindness (HP:0000618)1.81062528
77Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79527405
78Dicarboxylic aciduria (HP:0003215)1.79527405
79Abnormal respiratory epithelium morphology (HP:0012253)1.77966840
80Abnormal respiratory motile cilium morphology (HP:0005938)1.77966840
81Neuroendocrine neoplasm (HP:0100634)1.77238462
82Pancytopenia (HP:0001876)1.77026169
83Abnormality of urine glucose concentration (HP:0011016)1.74950951
84Glycosuria (HP:0003076)1.74950951
85Hypothermia (HP:0002045)1.68329666
86Sensory axonal neuropathy (HP:0003390)1.67205798
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66668133
88Hyperglycinemia (HP:0002154)1.66416538
89Pheochromocytoma (HP:0002666)1.65908920
90Fragile nails (HP:0001808)1.63848894
91Maternal diabetes (HP:0009800)1.63411318
92Medial flaring of the eyebrow (HP:0010747)1.62543967
93Triphalangeal thumb (HP:0001199)1.61286633
94Lethargy (HP:0001254)1.60287379
95Testicular atrophy (HP:0000029)1.60278827
96Type 2 muscle fiber atrophy (HP:0003554)1.59043904
97Aplasia/Hypoplasia involving the musculature (HP:0001460)1.58964774
98Depressed nasal ridge (HP:0000457)1.58316778
99Abnormal protein glycosylation (HP:0012346)1.57469000
100Abnormal glycosylation (HP:0012345)1.57469000
101Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.57469000
102Abnormal protein N-linked glycosylation (HP:0012347)1.57469000
103Congenital stationary night blindness (HP:0007642)1.57056373
104Muscle fiber atrophy (HP:0100295)1.56870142
105Horseshoe kidney (HP:0000085)1.55851645
106Partial duplication of thumb phalanx (HP:0009944)1.55675421
107Absent thumb (HP:0009777)1.55558175
108Renal tubular dysfunction (HP:0000124)1.54263603
109Vomiting (HP:0002013)1.53752213
110Rhinitis (HP:0012384)1.52491790
111Abnormal trabecular bone morphology (HP:0100671)1.52398243
112Abnormality of the labia minora (HP:0012880)1.52098648
113Abnormal rod and cone electroretinograms (HP:0008323)1.51947353
114Gliosis (HP:0002171)1.51604614
115Poor suck (HP:0002033)1.51273019
116Partial duplication of the phalanx of hand (HP:0009999)1.49012474
117Progressive external ophthalmoplegia (HP:0000590)1.47929752
118Hypoplasia of the uterus (HP:0000013)1.47642267
119Hypoplasia of the radius (HP:0002984)1.46493141
120Multiple enchondromatosis (HP:0005701)1.46444495
121Sclerocornea (HP:0000647)1.45922739
122Type I transferrin isoform profile (HP:0003642)1.45730110
123Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.45710776
124Abnormal ciliary motility (HP:0012262)1.43345796
125Glossoptosis (HP:0000162)1.43270834
126Hypoplastic left heart (HP:0004383)1.42675397
127Congenital, generalized hypertrichosis (HP:0004540)1.40807858
128Adrenal hypoplasia (HP:0000835)1.40620273
129Abnormality of dentin (HP:0010299)1.40208034
130Aplastic anemia (HP:0001915)1.39998346
131Double outlet right ventricle (HP:0001719)1.39993029
132Congenital malformation of the right heart (HP:0011723)1.39993029
133Cleft eyelid (HP:0000625)1.39683034

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.08949569
2NME24.19613499
3BUB14.12857879
4TLK13.52001484
5NME13.17550830
6PBK3.04055212
7STK162.94058549
8LIMK12.63115400
9MAP3K122.53400239
10TESK22.32712161
11BCKDK2.29340751
12EIF2AK12.28401052
13VRK12.13906229
14TESK12.13582903
15ARAF2.07965884
16WEE12.02845949
17STK391.97163718
18CDC71.91358817
19SRPK11.91154154
20MYLK1.81948124
21PIM21.78225436
22MST41.73646937
23DYRK21.68987874
24BRAF1.65018955
25PNCK1.62414704
26WNK31.61551531
27CASK1.45812045
28GRK71.42669341
29TAF11.39165365
30BCR1.38848210
31CDK191.32534348
32NUAK11.32083420
33PLK41.27621459
34EIF2AK31.24351612
35GRK11.23997442
36MARK11.21567095
37ILK1.19701125
38MAP4K21.18091773
39AURKA1.16410203
40GRK51.15298223
41OXSR11.15060501
42DAPK31.12036967
43UHMK11.11805761
44WNK41.11390684
45BMPR1B1.07447923
46ABL21.06592979
47MAPKAPK51.01941139
48PHKG20.99003686
49PHKG10.99003686
50MAPK150.96633120
51INSRR0.95903324
52PASK0.95083157
53PAK10.91954074
54RPS6KB20.90052648
55PDK20.89397674
56MAP3K110.87717741
57RPS6KA50.85262410
58MAP2K20.84157269
59CAMK2B0.83025849
60EPHB20.81031857
61EPHA20.80837317
62CDK140.80580619
63ADRBK20.78919533
64CSNK1G30.76652152
65CSNK1G20.75310833
66CHEK20.75301319
67CCNB10.75073847
68NEK10.74946962
69ROCK20.74360696
70ADRBK10.73535505
71MKNK10.72753578
72MUSK0.72236316
73IRAK20.68747680
74CDK180.68704679
75MAPK130.68610302
76DYRK30.68445462
77KDR0.67864374
78CDK11A0.67375127
79CDK150.67236569
80PLK10.66786085
81CAMK2D0.63972367
82CSNK2A10.63570145
83PLK30.62785611
84OBSCN0.61883617
85CSNK2A20.61692354
86ZAK0.60119220
87BLK0.60049264
88PAK40.58410345
89TSSK60.57936372
90CAMK2G0.56905443
91AURKB0.54652779
92PLK20.54265112
93PRKCI0.54008994
94LRRK20.50701314
95TNIK0.50334773
96LATS20.50056299
97DAPK10.49439435
98LMTK20.49147352
99FGR0.49049171
100BMPR20.48221282
101CAMK2A0.48198467
102MAP3K40.47828928
103CDK80.45419162
104EPHA40.42886551
105STK40.40750925
106EIF2AK20.40636668
107MINK10.39741037
108ATR0.38619830
109CAMK10.38113391
110PKN10.36614129
111CSNK1A1L0.36570547
112NEK20.36326250
113CSNK1A10.35711349
114PAK30.35367389
115YES10.35112151
116NTRK20.34446920
117TXK0.33902304
118PTK2B0.33545267
119TTK0.32117097
120CDK70.31784605
121PINK10.31770121
122PRKCG0.31629041
123MOS0.31425163
124PRKACA0.30390823
125MAP3K80.29055458
126IKBKB0.28876461
127BRSK10.28156838
128ROCK10.27498911
129CSNK1E0.25541435
130CSNK1G10.24928477
131MAP2K70.22572787

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.99190789
2Oxidative phosphorylation_Homo sapiens_hsa001905.84826936
3Parkinsons disease_Homo sapiens_hsa050125.13041862
4Proteasome_Homo sapiens_hsa030504.51971605
5Huntingtons disease_Homo sapiens_hsa050163.81587997
6Alzheimers disease_Homo sapiens_hsa050103.72951877
7RNA polymerase_Homo sapiens_hsa030203.42817705
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.11512448
9Cardiac muscle contraction_Homo sapiens_hsa042602.44124048
10Protein export_Homo sapiens_hsa030602.38185774
11Pyrimidine metabolism_Homo sapiens_hsa002401.92892744
12Spliceosome_Homo sapiens_hsa030401.91796862
13DNA replication_Homo sapiens_hsa030301.77961995
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76752325
15Mismatch repair_Homo sapiens_hsa034301.73755994
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60781246
17Nucleotide excision repair_Homo sapiens_hsa034201.58047238
18Collecting duct acid secretion_Homo sapiens_hsa049661.51660460
19Homologous recombination_Homo sapiens_hsa034401.33721927
20Vibrio cholerae infection_Homo sapiens_hsa051101.18569768
21RNA transport_Homo sapiens_hsa030131.12117124
22Basal transcription factors_Homo sapiens_hsa030221.10442376
23Purine metabolism_Homo sapiens_hsa002301.02399199
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96416640
25Base excision repair_Homo sapiens_hsa034100.93783934
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93711102
27Glutathione metabolism_Homo sapiens_hsa004800.85993816
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84197040
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79493200
30Fatty acid elongation_Homo sapiens_hsa000620.79018864
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77080867
32Maturity onset diabetes of the young_Homo sapiens_hsa049500.75030693
33RNA degradation_Homo sapiens_hsa030180.73002289
34Ether lipid metabolism_Homo sapiens_hsa005650.72824149
35Steroid biosynthesis_Homo sapiens_hsa001000.72398671
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72053018
37Arachidonic acid metabolism_Homo sapiens_hsa005900.71790287
38Fanconi anemia pathway_Homo sapiens_hsa034600.70498540
39Metabolic pathways_Homo sapiens_hsa011000.70412808
40Peroxisome_Homo sapiens_hsa041460.67431775
41Synaptic vesicle cycle_Homo sapiens_hsa047210.66060714
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63766677
43Butanoate metabolism_Homo sapiens_hsa006500.63450882
44Sulfur relay system_Homo sapiens_hsa041220.62874374
45Rheumatoid arthritis_Homo sapiens_hsa053230.61789317
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61773605
47Sulfur metabolism_Homo sapiens_hsa009200.61488489
48Chemical carcinogenesis_Homo sapiens_hsa052040.60879891
49Systemic lupus erythematosus_Homo sapiens_hsa053220.59205147
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58227887
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57248979
52Nitrogen metabolism_Homo sapiens_hsa009100.57166155
53Epstein-Barr virus infection_Homo sapiens_hsa051690.56532656
54Tryptophan metabolism_Homo sapiens_hsa003800.55663138
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55024588
56Alcoholism_Homo sapiens_hsa050340.54691203
57Linoleic acid metabolism_Homo sapiens_hsa005910.54145414
58Non-homologous end-joining_Homo sapiens_hsa034500.53680624
59Propanoate metabolism_Homo sapiens_hsa006400.50961643
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50185600
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50124364
62Cell cycle_Homo sapiens_hsa041100.49766676
63Phototransduction_Homo sapiens_hsa047440.49261965
64Serotonergic synapse_Homo sapiens_hsa047260.46479249
65Tyrosine metabolism_Homo sapiens_hsa003500.45915892
66Phagosome_Homo sapiens_hsa041450.45680347
67Nicotine addiction_Homo sapiens_hsa050330.43215960
68Phenylalanine metabolism_Homo sapiens_hsa003600.43186446
69Graft-versus-host disease_Homo sapiens_hsa053320.42210847
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.41158397
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.40112639
72Vitamin digestion and absorption_Homo sapiens_hsa049770.39993211
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39871291
74Hedgehog signaling pathway_Homo sapiens_hsa043400.36636336
75Caffeine metabolism_Homo sapiens_hsa002320.36300097
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35874508
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35084294
78Folate biosynthesis_Homo sapiens_hsa007900.33949075
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32867321
80Pyruvate metabolism_Homo sapiens_hsa006200.32079615
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31794653
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31400295
83Retinol metabolism_Homo sapiens_hsa008300.31304562
84Autoimmune thyroid disease_Homo sapiens_hsa053200.30942670
85Selenocompound metabolism_Homo sapiens_hsa004500.28637199
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28428861
87Asthma_Homo sapiens_hsa053100.28168170
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.27192133
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27111180
90Oocyte meiosis_Homo sapiens_hsa041140.26345805
91Sphingolipid metabolism_Homo sapiens_hsa006000.25961431
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25768525
93beta-Alanine metabolism_Homo sapiens_hsa004100.25448552
94p53 signaling pathway_Homo sapiens_hsa041150.25234739
95Regulation of autophagy_Homo sapiens_hsa041400.25204023
96mRNA surveillance pathway_Homo sapiens_hsa030150.24325194
97Fatty acid degradation_Homo sapiens_hsa000710.24274313
98Fructose and mannose metabolism_Homo sapiens_hsa000510.23167864
99Vitamin B6 metabolism_Homo sapiens_hsa007500.23017499
100N-Glycan biosynthesis_Homo sapiens_hsa005100.22663706
101Biosynthesis of amino acids_Homo sapiens_hsa012300.21158070
102Pentose phosphate pathway_Homo sapiens_hsa000300.21010821
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.20979560
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20087223
105Taste transduction_Homo sapiens_hsa047420.19942864
106One carbon pool by folate_Homo sapiens_hsa006700.19540766
107Fat digestion and absorption_Homo sapiens_hsa049750.19494257
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18175902
109Arginine and proline metabolism_Homo sapiens_hsa003300.17795937
110Carbon metabolism_Homo sapiens_hsa012000.17510382
111Allograft rejection_Homo sapiens_hsa053300.16858406
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16836105
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16296260
114Olfactory transduction_Homo sapiens_hsa047400.16222572
115Basal cell carcinoma_Homo sapiens_hsa052170.14775910
116Tight junction_Homo sapiens_hsa045300.12194056
117Axon guidance_Homo sapiens_hsa043600.11638671
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10547209
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09545448
120Dopaminergic synapse_Homo sapiens_hsa047280.08109810
121GABAergic synapse_Homo sapiens_hsa047270.04816072
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.04762044
123* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.03821219
124Melanogenesis_Homo sapiens_hsa049160.03007260
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.02792340
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.02231525
127Type I diabetes mellitus_Homo sapiens_hsa049400.01811685
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.01462767
129Cocaine addiction_Homo sapiens_hsa050300.01155132
130Gap junction_Homo sapiens_hsa045400.01030311
131Mineral absorption_Homo sapiens_hsa049780.00702964

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