ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of mast cell activation (GO:0033004)	8.40235089
2	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	6.93954533
3	regulation of activation of Janus kinase activity (GO:0010533)	6.04829116
4	protein neddylation (GO:0045116)	5.75973553
5	negative regulation of phagocytosis (GO:0050765)	5.58712682
6	regulation of B cell receptor signaling pathway (GO:0050855)	5.35430901
7	DNA deamination (GO:0045006)	5.29992068
8	behavioral response to nicotine (GO:0035095)	5.03252166
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.00319701
10	ATP synthesis coupled proton transport (GO:0015986)	5.00319701
11	maturation of SSU-rRNA (GO:0030490)	4.94100981
12	peptidyl-histidine modification (GO:0018202)	4.75665927
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.62707727
14	cellular response to ATP (GO:0071318)	4.62666995
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.44071772
16	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.40481503
17	maturation of 5.8S rRNA (GO:0000460)	4.26663771
18	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.24664161
19	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.24664161
20	NADH dehydrogenase complex assembly (GO:0010257)	4.24664161
21	protein complex biogenesis (GO:0070271)	4.14081498
22	platelet dense granule organization (GO:0060155)	3.93161508
23	sequestering of actin monomers (GO:0042989)	3.92117647
24	negative regulation of B cell proliferation (GO:0030889)	3.86390925
25	rRNA catabolic process (GO:0016075)	3.78102358
26	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.70410437
27	negative regulation of alpha-beta T cell activation (GO:0046636)	3.67681582
28	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.67078951
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.66385905
30	ribosomal small subunit assembly (GO:0000028)	3.53674604
31	GTP biosynthetic process (GO:0006183)	3.53018855
32	glycerophospholipid catabolic process (GO:0046475)	3.46290040
33	base-excision repair, AP site formation (GO:0006285)	3.42080533
34	interferon-gamma production (GO:0032609)	3.36438527
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.33743598
36	positive regulation of phosphatase activity (GO:0010922)	3.26107632
37	electron transport chain (GO:0022900)	3.24894661
38	negative regulation of telomere maintenance (GO:0032205)	3.23729522
39	myoblast migration (GO:0051451)	3.21627693
40	cytidine metabolic process (GO:0046087)	3.17297616
41	cytidine catabolic process (GO:0006216)	3.17297616
42	cytidine deamination (GO:0009972)	3.17297616
43	epithelial cilium movement (GO:0003351)	3.16559895
44	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.15265821
45	regulation of T cell receptor signaling pathway (GO:0050856)	3.15050392
46	respiratory electron transport chain (GO:0022904)	3.14989803
47	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.12100766
48	mannosylation (GO:0097502)	3.11126436
49	ncRNA catabolic process (GO:0034661)	3.10110897
50	tyrosine phosphorylation of STAT protein (GO:0007260)	3.08848049
51	response to pheromone (GO:0019236)	3.04567794
52	ATP biosynthetic process (GO:0006754)	3.03343811
53	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	3.00490593
54	negative regulation of leukocyte migration (GO:0002686)	2.84432229
55	synaptic transmission, cholinergic (GO:0007271)	2.84074261
56	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.83733340
57	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.83733340
58	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.83688585
59	regulation of mast cell activation (GO:0033003)	2.82871410
60	DNA double-strand break processing (GO:0000729)	2.80448823
61	UTP biosynthetic process (GO:0006228)	2.77289432
62	water-soluble vitamin biosynthetic process (GO:0042364)	2.73869614
63	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.73275681
64	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.71320415
65	regulation of microtubule-based movement (GO:0060632)	2.71066073
66	endoderm formation (GO:0001706)	2.67831524
67	regulation of thymocyte apoptotic process (GO:0070243)	2.66943282
68	hydrogen ion transmembrane transport (GO:1902600)	2.65945178
69	cytolysis (GO:0019835)	2.65400935
70	fucose catabolic process (GO:0019317)	2.64150112
71	L-fucose metabolic process (GO:0042354)	2.64150112
72	L-fucose catabolic process (GO:0042355)	2.64150112
73	UTP metabolic process (GO:0046051)	2.63104386
74	negative regulation of thymocyte apoptotic process (GO:0070244)	2.62882039
75	adenosine metabolic process (GO:0046085)	2.62260054
76	transmission of nerve impulse (GO:0019226)	2.60274643
77	negative regulation of leukocyte mediated immunity (GO:0002704)	2.60031486
78	regulation of cilium movement (GO:0003352)	2.56938311
79	axonemal dynein complex assembly (GO:0070286)	2.56297505
80	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.55693182
81	cilium movement (GO:0003341)	2.53676041
82	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.53404648
83	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.52423271
84	regulation of mast cell activation involved in immune response (GO:0033006)	2.52270640
85	DNA replication checkpoint (GO:0000076)	2.51764969
86	iron ion import (GO:0097286)	2.48466001
87	regulation of mast cell degranulation (GO:0043304)	2.47040194
88	negative regulation of B cell activation (GO:0050869)	2.46197908
89	parturition (GO:0007567)	2.45019033
90	ribosomal small subunit biogenesis (GO:0042274)	2.44520616
91	histone mRNA catabolic process (GO:0071044)	2.43546449
92	resolution of meiotic recombination intermediates (GO:0000712)	2.42419614
93	photoreceptor cell development (GO:0042461)	2.41497716
94	proton transport (GO:0015992)	2.40963146
95	motile cilium assembly (GO:0044458)	2.39908824
96	positive regulation of T cell apoptotic process (GO:0070234)	2.39331612
97	negative regulation of T cell mediated immunity (GO:0002710)	2.38449392
98	hydrogen transport (GO:0006818)	2.38136029
99	positive regulation of calcium-mediated signaling (GO:0050850)	2.37412712
100	nucleoside diphosphate phosphorylation (GO:0006165)	2.37162346

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.66678447
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.50744511
3	EZH2_22144423_ChIP-Seq_EOC_Human	4.19729056
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.13197627
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.43971686
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.87283062
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.70099337
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.23561662
9	VDR_22108803_ChIP-Seq_LS180_Human	2.21637850
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.15851728
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.14614095
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14585835
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.13540275
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.12359043
15	IGF1R_20145208_ChIP-Seq_DFB_Human	1.99527722
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.96383551
17	ELK1_19687146_ChIP-ChIP_HELA_Human	1.91777781
18	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.83636066
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.72139715
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68199189
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.66617441
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64779593
23	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.57916083
24	TAF2_19829295_ChIP-Seq_ESCs_Human	1.56769523
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.51732353
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46982598
27	NCOR_22424771_ChIP-Seq_293T_Human	1.42410011
28	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.41277544
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.36717959
30	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.33382725
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32973634
32	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.32608214
33	AR_20517297_ChIP-Seq_VCAP_Human	1.31941347
34	NANOG_20526341_ChIP-Seq_ESCs_Human	1.31596545
35	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.31459259
36	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.30141658
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29920571
38	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.27798155
39	AR_21572438_ChIP-Seq_LNCaP_Human	1.26687679
40	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25773887
41	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.25429442
42	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22488660
43	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.21607741
44	ER_23166858_ChIP-Seq_MCF-7_Human	1.20669617
45	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.19936164
46	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.19863146
47	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.17672441
48	EWS_26573619_Chip-Seq_HEK293_Human	1.17331667
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16884538
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16798551
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16798551
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16697488
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.15238337
54	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.14375238
55	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.13334478
56	P300_19829295_ChIP-Seq_ESCs_Human	1.12780473
57	VDR_23849224_ChIP-Seq_CD4+_Human	1.11684282
58	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.11532844
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.10405964
60	GATA3_26560356_Chip-Seq_TH2_Human	1.10404480
61	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.09779631
62	MYC_19829295_ChIP-Seq_ESCs_Human	1.08957611
63	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08400961
64	ERG_20517297_ChIP-Seq_VCAP_Human	1.08065761
65	CTCF_20526341_ChIP-Seq_ESCs_Human	1.06678029
66	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.05718962
67	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.05021609
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03239553
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02557221
70	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.00136420
71	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.99927336
72	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98771892
73	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.98677142
74	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98587546
75	FOXP3_21729870_ChIP-Seq_TREG_Human	0.97824142
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97346445
77	P300_27268052_Chip-Seq_Bcells_Human	0.97077205
78	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.96862059
79	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.96856676
80	OCT4_20526341_ChIP-Seq_ESCs_Human	0.95896617
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.95467669
82	CBP_20019798_ChIP-Seq_JUKART_Human	0.95467669
83	GBX2_23144817_ChIP-Seq_PC3_Human	0.95251239
84	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.94354536
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94262852
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94201444
87	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.93925751
88	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.93426713
89	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.92839575
90	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.92499557
91	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92115314
92	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.90815437
93	TCF4_22108803_ChIP-Seq_LS180_Human	0.89831404
94	BCL6_27268052_Chip-Seq_Bcells_Human	0.88891170
95	NANOG_19829295_ChIP-Seq_ESCs_Human	0.88634790
96	SOX2_19829295_ChIP-Seq_ESCs_Human	0.88634790
97	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.87748569
98	ERA_21632823_ChIP-Seq_H3396_Human	0.87478222
99	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.86207555
100	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.85874598

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	3.98508528
2	MP0003646_muscle_fatigue	3.91755204
3	MP0004142_abnormal_muscle_tone	3.19316777
4	MP0005671_abnormal_response_to	2.62117293
5	MP0002102_abnormal_ear_morphology	2.53447843
6	MP0004885_abnormal_endolymph	2.49605306
7	MP0004145_abnormal_muscle_electrophysio	2.42353653
8	MP0009379_abnormal_foot_pigmentation	2.35473242
9	MP0006072_abnormal_retinal_apoptosis	2.30083455
10	MP0005551_abnormal_eye_electrophysiolog	2.11416178
11	MP0002736_abnormal_nociception_after	2.04000999
12	MP0001968_abnormal_touch/_nociception	1.99807164
13	MP0002653_abnormal_ependyma_morphology	1.97701052
14	MP0005084_abnormal_gallbladder_morpholo	1.82706298
15	MP0008872_abnormal_physiological_respon	1.75782605
16	MP0005646_abnormal_pituitary_gland	1.75206470
17	MP0003878_abnormal_ear_physiology	1.72134405
18	MP0005377_hearing/vestibular/ear_phenot	1.72134405
19	MP0006292_abnormal_olfactory_placode	1.71435667
20	MP0002166_altered_tumor_susceptibility	1.71017212
21	MP0005174_abnormal_tail_pigmentation	1.67684283
22	MP0001919_abnormal_reproductive_system	1.65213067
23	MP0009333_abnormal_splenocyte_physiolog	1.64947308
24	MP0005464_abnormal_platelet_physiology	1.64807316
25	MP0003806_abnormal_nucleotide_metabolis	1.57441868
26	MP0002638_abnormal_pupillary_reflex	1.54519303
27	MP0003718_maternal_effect	1.51795626
28	MP0001873_stomach_inflammation	1.50421031
29	MP0001835_abnormal_antigen_presentation	1.47282353
30	MP0002006_tumorigenesis	1.44629192
31	MP0005253_abnormal_eye_physiology	1.40097153
32	MP0000049_abnormal_middle_ear	1.37457875
33	MP0002272_abnormal_nervous_system	1.36680796
34	MP0005389_reproductive_system_phenotype	1.35845624
35	MP0004742_abnormal_vestibular_system	1.33024180
36	MP0008775_abnormal_heart_ventricle	1.29835686
37	MP0005387_immune_system_phenotype	1.26827089
38	MP0001790_abnormal_immune_system	1.26827089
39	MP0008877_abnormal_DNA_methylation	1.26805729
40	MP0001800_abnormal_humoral_immune	1.26680848
41	MP0008875_abnormal_xenobiotic_pharmacok	1.25021002
42	MP0003638_abnormal_response/metabolism_	1.22364979
43	MP0009745_abnormal_behavioral_response	1.21673666
44	MP0006036_abnormal_mitochondrial_physio	1.19863688
45	MP0005636_abnormal_mineral_homeostasis	1.17555904
46	MP0000230_abnormal_systemic_arterial	1.15628864
47	MP0006276_abnormal_autonomic_nervous	1.15200566
48	MP0001485_abnormal_pinna_reflex	1.13970342
49	MP0002837_dystrophic_cardiac_calcinosis	1.13353152
50	MP0001905_abnormal_dopamine_level	1.10253237
51	MP0002138_abnormal_hepatobiliary_system	1.08933631
52	MP0000015_abnormal_ear_pigmentation	1.06378889
53	MP0002095_abnormal_skin_pigmentation	1.05993043
54	MP0003880_abnormal_central_pattern	1.05972650
55	MP0004130_abnormal_muscle_cell	1.05932281
56	MP0002723_abnormal_immune_serum	1.03412383
57	MP0003635_abnormal_synaptic_transmissio	1.03045226
58	MP0003315_abnormal_perineum_morphology	1.00825346
59	MP0005000_abnormal_immune_tolerance	1.00163123
60	MP0003879_abnormal_hair_cell	0.98381289
61	MP0003186_abnormal_redox_activity	0.97999598
62	MP0004043_abnormal_pH_regulation	0.96052100
63	MP0004133_heterotaxia	0.92406729
64	MP0009785_altered_susceptibility_to	0.91329797
65	MP0002557_abnormal_social/conspecific_i	0.91110350
66	MP0002148_abnormal_hypersensitivity_rea	0.90986400
67	MP0005195_abnormal_posterior_eye	0.90835896
68	MP0003011_delayed_dark_adaptation	0.90124873
69	MP0001663_abnormal_digestive_system	0.89888443
70	MP0002733_abnormal_thermal_nociception	0.89515496
71	MP0003119_abnormal_digestive_system	0.88377445
72	MP0008789_abnormal_olfactory_epithelium	0.86183664
73	MP0002420_abnormal_adaptive_immunity	0.85955062
74	MP0001486_abnormal_startle_reflex	0.84466906
75	MP0001819_abnormal_immune_cell	0.84367815
76	MP0002452_abnormal_antigen_presenting	0.83904859
77	MP0002277_abnormal_respiratory_mucosa	0.80742229
78	MP0000685_abnormal_immune_system	0.80505865
79	MP0002405_respiratory_system_inflammati	0.79755561
80	MP0003724_increased_susceptibility_to	0.79081323
81	MP0002572_abnormal_emotion/affect_behav	0.78692508
82	MP0001963_abnormal_hearing_physiology	0.78582317
83	MP0001440_abnormal_grooming_behavior	0.78108786
84	MP0005410_abnormal_fertilization	0.77745641
85	MP0001756_abnormal_urination	0.77683391
86	MP0002160_abnormal_reproductive_system	0.75875423
87	MP0009764_decreased_sensitivity_to	0.74412622
88	MP0001324_abnormal_eye_pigmentation	0.73749970
89	MP0005075_abnormal_melanosome_morpholog	0.73153098
90	MP0002184_abnormal_innervation	0.72801002
91	MP0002063_abnormal_learning/memory/cond	0.72696115
92	MP0001970_abnormal_pain_threshold	0.71265008
93	MP0000613_abnormal_salivary_gland	0.70815365
94	MP0005332_abnormal_amino_acid	0.69589856
95	MP0003195_calcinosis	0.69357125
96	MP0001765_abnormal_ion_homeostasis	0.69330228
97	MP0005025_abnormal_response_to	0.69207623
98	MP0000703_abnormal_thymus_morphology	0.68120865
99	MP0005360_urolithiasis	0.67859978
100	MP0001501_abnormal_sleep_pattern	0.67748328

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.21202259
2	Acute necrotizing encephalopathy (HP:0006965)	3.96589868
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.56454559
4	Hypoproteinemia (HP:0003075)	3.53594283
5	Abnormality of the renal cortex (HP:0011035)	3.28694992
6	Acute encephalopathy (HP:0006846)	3.26593343
7	Progressive macrocephaly (HP:0004481)	3.26211522
8	Hypoplasia of the pons (HP:0012110)	3.20864309
9	Mitochondrial inheritance (HP:0001427)	3.20262899
10	Congenital stationary night blindness (HP:0007642)	3.15499377
11	Severe visual impairment (HP:0001141)	3.14076811
12	Pancreatic cysts (HP:0001737)	3.13651232
13	Abnormality of DNA repair (HP:0003254)	3.11824571
14	Abnormality of the pons (HP:0007361)	3.11009697
15	Polydipsia (HP:0001959)	3.08482315
16	Abnormal drinking behavior (HP:0030082)	3.08482315
17	Molar tooth sign on MRI (HP:0002419)	3.08380868
18	Abnormality of midbrain morphology (HP:0002418)	3.08380868
19	Dyschromatopsia (HP:0007641)	3.07186567
20	Nephronophthisis (HP:0000090)	3.03352544
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.02311812
22	Increased hepatocellular lipid droplets (HP:0006565)	2.91559892
23	Pendular nystagmus (HP:0012043)	2.85304219
24	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.85268635
25	Increased CSF lactate (HP:0002490)	2.82148246
26	Pancreatic fibrosis (HP:0100732)	2.77117916
27	Absent thumb (HP:0009777)	2.76569358
28	Tubular atrophy (HP:0000092)	2.75567185
29	Abnormal respiratory epithelium morphology (HP:0012253)	2.74490778
30	Abnormal respiratory motile cilium morphology (HP:0005938)	2.74490778
31	Renal Fanconi syndrome (HP:0001994)	2.72732040
32	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.70979116
33	Increased corneal curvature (HP:0100692)	2.68998193
34	Keratoconus (HP:0000563)	2.68998193
35	IgG deficiency (HP:0004315)	2.67172448
36	Decreased central vision (HP:0007663)	2.65448290
37	Stomatitis (HP:0010280)	2.62168264
38	Absent/shortened dynein arms (HP:0200106)	2.58327667
39	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.58327667
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.55887703
41	Abnormal biliary tract physiology (HP:0012439)	2.55071378
42	Bile duct proliferation (HP:0001408)	2.55071378
43	Abolished electroretinogram (ERG) (HP:0000550)	2.53718765
44	Lipid accumulation in hepatocytes (HP:0006561)	2.49562123
45	Chronic hepatic failure (HP:0100626)	2.48695437
46	Abnormality of the renal medulla (HP:0100957)	2.48156465
47	Asplenia (HP:0001746)	2.48073555
48	Type II lissencephaly (HP:0007260)	2.47913734
49	Elevated erythrocyte sedimentation rate (HP:0003565)	2.47602057
50	True hermaphroditism (HP:0010459)	2.45433749
51	Supernumerary spleens (HP:0009799)	2.42689591
52	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.42615991
53	Hyperlipoproteinemia (HP:0010980)	2.40681066
54	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.38527727
55	Prostate neoplasm (HP:0100787)	2.34679736
56	Abnormality of the renal collecting system (HP:0004742)	2.33216721
57	Increased intramyocellular lipid droplets (HP:0012240)	2.32301216
58	Reticulocytopenia (HP:0001896)	2.28310658
59	Polyuria (HP:0000103)	2.28071887
60	Abnormal ciliary motility (HP:0012262)	2.27845912
61	Tubulointerstitial fibrosis (HP:0005576)	2.27384498
62	Clubbing of toes (HP:0100760)	2.25950980
63	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.23434650
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.23434650
65	Abnormal protein glycosylation (HP:0012346)	2.23033176
66	Abnormal glycosylation (HP:0012345)	2.23033176
67	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.23033176
68	Abnormal protein N-linked glycosylation (HP:0012347)	2.23033176
69	Renovascular hypertension (HP:0100817)	2.21146397
70	Cerebral edema (HP:0002181)	2.20619297
71	Infertility (HP:0000789)	2.19977470
72	Exertional dyspnea (HP:0002875)	2.18511685
73	Methylmalonic acidemia (HP:0002912)	2.18102047
74	Agitation (HP:0000713)	2.17897537
75	Encephalitis (HP:0002383)	2.17819097
76	Lissencephaly (HP:0001339)	2.15359500
77	Abnormality of the ileum (HP:0001549)	2.10773772
78	Impulsivity (HP:0100710)	2.10601795
79	Meckel diverticulum (HP:0002245)	2.09926967
80	Renal cortical cysts (HP:0000803)	2.06202987
81	Colon cancer (HP:0003003)	2.05015778
82	Testicular atrophy (HP:0000029)	2.03418998
83	Abnormality of the carotid arteries (HP:0005344)	2.03397573
84	Methylmalonic aciduria (HP:0012120)	1.98148405
85	Duplicated collecting system (HP:0000081)	1.95890016
86	Cystic liver disease (HP:0006706)	1.94807718
87	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.94408808
88	Abnormality of alanine metabolism (HP:0010916)	1.94408808
89	Hyperalaninemia (HP:0003348)	1.94408808
90	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.93803731
91	Paralysis (HP:0003470)	1.90962926
92	Glycosuria (HP:0003076)	1.87770497
93	Abnormality of urine glucose concentration (HP:0011016)	1.87770497
94	Type I transferrin isoform profile (HP:0003642)	1.87171605
95	Autoimmune hemolytic anemia (HP:0001890)	1.85167719
96	Abnormality of renal resorption (HP:0011038)	1.83037247
97	Cerebellar dysplasia (HP:0007033)	1.82871082
98	Abnormal urine output (HP:0012590)	1.79542525
99	Optic disc pallor (HP:0000543)	1.78784539
100	Decreased subcutaneous fat (HP:0001002)	1.78234375

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LIMK1	4.52624402
2	CAMKK2	3.49819465
3	CDK8	3.25224489
4	VRK2	3.20651763
5	MST4	3.09000343
6	TXK	2.75836930
7	GRK1	2.49129411
8	ADRBK2	2.45904160
9	WNK4	2.38835530
10	TAOK3	2.18350605
11	BRSK1	2.15723795
12	TLK1	1.99129776
13	TIE1	1.91725014
14	KDR	1.89795623
15	FRK	1.76672438
16	EPHB2	1.72959618
17	STK39	1.61652029
18	CAMKK1	1.59966574
19	CDC42BPA	1.55668288
20	OXSR1	1.41825256
21	EIF2AK3	1.39698949
22	BTK	1.39129358
23	NME1	1.34296006
24	PTK2B	1.26895681
25	EIF2AK1	1.25371355
26	SYK	1.24059086
27	DYRK2	1.19617827
28	TEC	1.16762840
29	TNIK	1.15593485
30	BRSK2	1.15350062
31	NUAK1	1.15248455
32	BUB1	1.14691353
33	PTK6	1.14351390
34	ITK	1.11701935
35	ZAK	1.11237527
36	IKBKB	1.07350951
37	DAPK2	1.07048636
38	VRK1	1.05801656
39	BCKDK	1.05491264
40	STK16	1.04562755
41	MYLK	1.04251585
42	MAP3K9	1.00734897
43	PIK3CG	0.99083833
44	CAMK1	0.93383540
45	MAP4K1	0.92179798
46	RIPK4	0.91808236
47	IKBKE	0.86851564
48	CAMK4	0.86217027
49	DYRK1B	0.85944698
50	WNK3	0.84736059
51	GRK5	0.80046156
52	GRK6	0.74912282
53	INSRR	0.74132464
54	LYN	0.72144190
55	IRAK4	0.70701556
56	FES	0.69708579
57	CLK1	0.68414215
58	MUSK	0.68264985
59	NEK9	0.66367712
60	ADRBK1	0.65464529
61	MAP4K2	0.61927505
62	ZAP70	0.61649986
63	MAPKAPK5	0.61308047
64	PIK3CA	0.59965018
65	AURKA	0.59036080
66	TAF1	0.58197533
67	PLK2	0.55570552
68	PAK3	0.54228481
69	NTRK2	0.52341131
70	PRKCG	0.52024434
71	OBSCN	0.50649292
72	ILK	0.49609904
73	DAPK3	0.47587734
74	LCK	0.46008580
75	PRKCQ	0.45989174
76	ERBB2	0.43957261
77	MAPK13	0.43464927
78	PRKACA	0.43114474
79	MAP2K2	0.42980518
80	MAP2K6	0.42655966
81	RPS6KA5	0.42012456
82	BMPR1B	0.41781913
83	PINK1	0.41369207
84	ROCK1	0.40599189
85	RPS6KA6	0.39733337
86	MAP3K12	0.39263189
87	PRKCE	0.38320103
88	DAPK1	0.37660457
89	TNK2	0.37603387
90	CSNK2A2	0.36635889
91	CAMK2A	0.35476326
92	PRKCA	0.35440845
93	BLK	0.34206679
94	PAK1	0.33093032
95	IGF1R	0.31929043
96	CSNK2A1	0.30752239
97	CSNK1D	0.29683173
98	PIM1	0.29604332
99	MAP2K1	0.28807362
100	ABL2	0.28766794

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.00255813
2	Parkinsons disease_Homo sapiens_hsa05012	3.55586251
3	Proteasome_Homo sapiens_hsa03050	2.86982366
4	Ribosome_Homo sapiens_hsa03010	2.80088310
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.54652090
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.42520864
7	Protein export_Homo sapiens_hsa03060	2.29161246
8	Alzheimers disease_Homo sapiens_hsa05010	2.28651955
9	Huntingtons disease_Homo sapiens_hsa05016	2.27991951
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.25597740
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.24081329
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.09025962
13	RNA polymerase_Homo sapiens_hsa03020	1.99814764
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.99202720
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.93971638
16	RNA degradation_Homo sapiens_hsa03018	1.91651784
17	Sulfur metabolism_Homo sapiens_hsa00920	1.77495673
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.74521454
19	Phototransduction_Homo sapiens_hsa04744	1.71084138
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.69638837
21	Nicotine addiction_Homo sapiens_hsa05033	1.61318050
22	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.59473478
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.56601282
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.54295778
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.49375514
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.45872190
27	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.45251625
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.44525290
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.42686339
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.40043154
31	Homologous recombination_Homo sapiens_hsa03440	1.36100763
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.34208451
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.30097787
34	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.29644783
35	Allograft rejection_Homo sapiens_hsa05330	1.27905955
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.26102338
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.19614496
38	Sulfur relay system_Homo sapiens_hsa04122	1.17758520
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.14835726
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.14095945
41	Graft-versus-host disease_Homo sapiens_hsa05332	1.12089805
42	Basal transcription factors_Homo sapiens_hsa03022	1.11078694
43	Fat digestion and absorption_Homo sapiens_hsa04975	1.04894970
44	Butanoate metabolism_Homo sapiens_hsa00650	1.00733861
45	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.99249537
46	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.97809484
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.91632834
48	Olfactory transduction_Homo sapiens_hsa04740	0.91361837
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.90340019
50	Glycerolipid metabolism_Homo sapiens_hsa00561	0.84590499
51	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.82205005
52	RNA transport_Homo sapiens_hsa03013	0.81191231
53	Peroxisome_Homo sapiens_hsa04146	0.78555033
54	Serotonergic synapse_Homo sapiens_hsa04726	0.75866298
55	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.75818420
56	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.75345412
57	Morphine addiction_Homo sapiens_hsa05032	0.72937004
58	One carbon pool by folate_Homo sapiens_hsa00670	0.72735456
59	Purine metabolism_Homo sapiens_hsa00230	0.71513713
60	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.69369680
61	Mismatch repair_Homo sapiens_hsa03430	0.65336524
62	Metabolic pathways_Homo sapiens_hsa01100	0.62637705
63	Mineral absorption_Homo sapiens_hsa04978	0.62596351
64	Caffeine metabolism_Homo sapiens_hsa00232	0.62075568
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61787398
66	Regulation of autophagy_Homo sapiens_hsa04140	0.61248561
67	Asthma_Homo sapiens_hsa05310	0.60540564
68	Retinol metabolism_Homo sapiens_hsa00830	0.58417086
69	Antigen processing and presentation_Homo sapiens_hsa04612	0.57342555
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56894105
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56334999
72	DNA replication_Homo sapiens_hsa03030	0.55103324
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54514030
74	Spliceosome_Homo sapiens_hsa03040	0.52333790
75	Selenocompound metabolism_Homo sapiens_hsa00450	0.50237218
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.47830486
77	Propanoate metabolism_Homo sapiens_hsa00640	0.46711056
78	Rheumatoid arthritis_Homo sapiens_hsa05323	0.45899260
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45698063
80	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.44824166
81	Platelet activation_Homo sapiens_hsa04611	0.44732177
82	Taste transduction_Homo sapiens_hsa04742	0.44356201
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.43722743
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42229207
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41563933
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.40040791
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38534112
88	GABAergic synapse_Homo sapiens_hsa04727	0.38106206
89	Circadian entrainment_Homo sapiens_hsa04713	0.36441873
90	Axon guidance_Homo sapiens_hsa04360	0.35070520
91	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.34664301
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.34584613
93	Base excision repair_Homo sapiens_hsa03410	0.34258764
94	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.33119287
95	ABC transporters_Homo sapiens_hsa02010	0.32823614
96	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.32695955
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32599027
98	Cocaine addiction_Homo sapiens_hsa05030	0.30968255
99	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.28982958
100	Histidine metabolism_Homo sapiens_hsa00340	0.28184891

TCEB2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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