TCEB2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)7.46258769
2DNA deamination (GO:0045006)6.77469502
3cytidine deamination (GO:0009972)6.48928426
4cytidine metabolic process (GO:0046087)6.48928426
5cytidine catabolic process (GO:0006216)6.48928426
6regulation of retinoic acid receptor signaling pathway (GO:0048385)6.30400137
7ribosomal small subunit assembly (GO:0000028)5.76067185
8pyrimidine ribonucleoside catabolic process (GO:0046133)5.53516151
9chaperone-mediated protein transport (GO:0072321)5.49741653
10maturation of SSU-rRNA (GO:0030490)5.36062085
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.00814008
12male meiosis I (GO:0007141)4.61971290
13ATP synthesis coupled proton transport (GO:0015986)4.33354513
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.33354513
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.32014830
16ribosomal small subunit biogenesis (GO:0042274)4.20023528
17viral transcription (GO:0019083)4.13048627
18pseudouridine synthesis (GO:0001522)4.09615423
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02982852
20electron transport chain (GO:0022900)4.01664272
21negative regulation of telomere maintenance (GO:0032205)3.98634379
22translational termination (GO:0006415)3.98432918
23respiratory electron transport chain (GO:0022904)3.98407012
24positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.89286384
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.80235279
26meiosis I (GO:0007127)3.76528848
27regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.74347854
28piRNA metabolic process (GO:0034587)3.68318669
29translational elongation (GO:0006414)3.65731221
30regulation of meiosis I (GO:0060631)3.65655425
31regulation of chronic inflammatory response (GO:0002676)3.65382009
32sequestering of actin monomers (GO:0042989)3.64406896
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.64241543
34behavioral response to nicotine (GO:0035095)3.62707390
35cotranslational protein targeting to membrane (GO:0006613)3.57259670
36protein targeting to ER (GO:0045047)3.53453261
37protein complex biogenesis (GO:0070271)3.49315617
38establishment of protein localization to endoplasmic reticulum (GO:0072599)3.35474593
39regulation of double-strand break repair via homologous recombination (GO:0010569)3.33617359
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.33272144
41NADH dehydrogenase complex assembly (GO:0010257)3.33272144
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33272144
43protein localization to endoplasmic reticulum (GO:0070972)3.32409728
44mitochondrial respiratory chain complex assembly (GO:0033108)3.27094156
45ubiquinone biosynthetic process (GO:0006744)3.24076203
46rRNA modification (GO:0000154)3.20062059
47positive regulation of respiratory burst (GO:0060267)3.17476097
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.10563020
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07430846
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07430846
51regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07344505
52hydrogen ion transmembrane transport (GO:1902600)3.05389804
53regulation of cellular respiration (GO:0043457)3.02259602
54negative regulation by host of viral transcription (GO:0043922)3.01980116
55cellular protein complex disassembly (GO:0043624)2.99897351
56translation (GO:0006412)2.99783435
57DNA demethylation (GO:0080111)2.98602177
58viral life cycle (GO:0019058)2.94754138
59protein neddylation (GO:0045116)2.91518625
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90276183
61purine deoxyribonucleotide catabolic process (GO:0009155)2.88632314
62pyrimidine nucleoside catabolic process (GO:0046135)2.85686006
63positive regulation of natural killer cell differentiation (GO:0032825)2.85021386
64regulation of activation of Janus kinase activity (GO:0010533)2.84517381
65negative regulation of mast cell activation (GO:0033004)2.84228085
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83998030
67transcription from mitochondrial promoter (GO:0006390)2.83843234
68protein-cofactor linkage (GO:0018065)2.83797819
69proton transport (GO:0015992)2.83665444
70rRNA processing (GO:0006364)2.81805966
71ubiquinone metabolic process (GO:0006743)2.81387678
72hydrogen transport (GO:0006818)2.76252422
73translational initiation (GO:0006413)2.75862851
74base-excision repair, AP site formation (GO:0006285)2.74766848
75positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.74486820
76male meiosis (GO:0007140)2.74420402
77rRNA metabolic process (GO:0016072)2.72210465
78maturation of 5.8S rRNA (GO:0000460)2.69294855
79transcription elongation from RNA polymerase III promoter (GO:0006385)2.66752035
80termination of RNA polymerase III transcription (GO:0006386)2.66752035
81positive regulation of prostaglandin secretion (GO:0032308)2.66455188
82spliceosomal complex assembly (GO:0000245)2.66285226
83quinone biosynthetic process (GO:1901663)2.64114812
84positive regulation of T cell apoptotic process (GO:0070234)2.63102604
85negative regulation of meiosis (GO:0045835)2.59815001
86respiratory chain complex IV assembly (GO:0008535)2.59698943
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.58045647
88regulation of cellular amino acid metabolic process (GO:0006521)2.56220660
89antigen processing and presentation via MHC class Ib (GO:0002475)2.56159116
90cellular ketone body metabolic process (GO:0046950)2.53614232
91platelet dense granule organization (GO:0060155)2.53003583
92regulation of mitochondrial translation (GO:0070129)2.52534618
93multicellular organism reproduction (GO:0032504)2.52290105
94positive regulation of natural killer cell mediated immunity (GO:0002717)2.52281919
95tRNA processing (GO:0008033)2.50468254
96negative regulation of calcium ion transport into cytosol (GO:0010523)2.49159046
97protein targeting to mitochondrion (GO:0006626)2.48346364
98cellular component biogenesis (GO:0044085)2.47898635
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.47223487
100protein K6-linked ubiquitination (GO:0085020)2.47164443

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.82491789
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.08053988
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.73543095
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.49621676
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.34204025
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.25787148
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92145460
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.92052070
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78934953
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78930771
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73994721
12ZNF274_21170338_ChIP-Seq_K562_Hela2.71385930
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.63870863
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55229818
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50401412
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.45687645
17VDR_22108803_ChIP-Seq_LS180_Human2.27770867
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99894055
19VDR_23849224_ChIP-Seq_CD4+_Human1.89989419
20TP53_22573176_ChIP-Seq_HFKS_Human1.84538483
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77718620
22YY1_21170310_ChIP-Seq_MESCs_Mouse1.63604021
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.61154905
24FOXP3_21729870_ChIP-Seq_TREG_Human1.56905865
25POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55550697
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50873032
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49173861
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.48434801
29ERA_21632823_ChIP-Seq_H3396_Human1.47801670
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45209687
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44547741
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.41357281
33NANOG_20526341_ChIP-Seq_ESCs_Human1.41310811
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40418956
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39938758
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35671990
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35495326
38TAF2_19829295_ChIP-Seq_ESCs_Human1.34054981
39MYC_19829295_ChIP-Seq_ESCs_Human1.33736554
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29301806
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.28637211
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28275956
43CTCF_20526341_ChIP-Seq_ESCs_Human1.28192757
44MYC_18940864_ChIP-ChIP_HL60_Human1.28081521
45FOXH1_21741376_ChIP-Seq_EPCs_Human1.27012830
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26563991
47AR_20517297_ChIP-Seq_VCAP_Human1.23003637
48ELK1_19687146_ChIP-ChIP_HELA_Human1.20199667
49HOXB7_26014856_ChIP-Seq_BT474_Human1.19947879
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19521122
51REST_21632747_ChIP-Seq_MESCs_Mouse1.18982403
52TTF2_22483619_ChIP-Seq_HELA_Human1.18841648
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18120536
54YY1_22570637_ChIP-Seq_MALME-3M_Human1.16848840
55CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13969817
56GATA3_26560356_Chip-Seq_TH2_Human1.12957602
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12131240
58NCOR_22424771_ChIP-Seq_293T_Human1.11651337
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10814672
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09612440
61GABP_19822575_ChIP-Seq_HepG2_Human1.07941128
62RNF2_27304074_Chip-Seq_NSC_Mouse1.05586553
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04357825
64TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02396202
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.02169437
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.02071622
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.01156306
68RAC3_21632823_ChIP-Seq_H3396_Human0.99662542
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98443234
70BCL6_27268052_Chip-Seq_Bcells_Human0.98301719
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97491333
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97483846
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97359971
74KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97017660
75ER_23166858_ChIP-Seq_MCF-7_Human0.96940601
76FOXH1_21741376_ChIP-Seq_ESCs_Human0.96196738
77E2F1_20622854_ChIP-Seq_HELA_Human0.94884184
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94698478
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94562991
80FOXA1_25329375_ChIP-Seq_VCAP_Human0.94320380
81FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94320380
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92824281
83EWS_26573619_Chip-Seq_HEK293_Human0.92721877
84E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91280644
85MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91103418
86POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90920919
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90874884
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90475069
89P53_21459846_ChIP-Seq_SAOS-2_Human0.89834943
90FLI1_27457419_Chip-Seq_LIVER_Mouse0.89616642
91REST_18959480_ChIP-ChIP_MESCs_Mouse0.88674576
92PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88173728
93CTCF_26484167_Chip-Seq_Bcells_Mouse0.88064259
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86511577
95EZH2_27294783_Chip-Seq_ESCs_Mouse0.85745002
96CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85102196
97MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84927938
98P300_27268052_Chip-Seq_Bcells_Human0.84655682
99BCOR_27268052_Chip-Seq_Bcells_Human0.83965957
100NANOG_19829295_ChIP-Seq_ESCs_Human0.83697537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.49247869
2MP0004147_increased_porphyrin_level3.92467783
3MP0003646_muscle_fatigue3.44510974
4MP0006292_abnormal_olfactory_placode3.40110651
5MP0001986_abnormal_taste_sensitivity2.87658063
6MP0008877_abnormal_DNA_methylation2.78743477
7MP0005671_abnormal_response_to2.75674567
8MP0008872_abnormal_physiological_respon2.71829915
9MP0001348_abnormal_lacrimal_gland2.57748262
10MP0004142_abnormal_muscle_tone2.22200980
11MP0002102_abnormal_ear_morphology2.18408372
12MP0002735_abnormal_chemical_nociception2.04854342
13MP0003718_maternal_effect1.95091786
14MP0004145_abnormal_muscle_electrophysio1.94510016
15MP0000566_synostosis1.88602096
16MP0002653_abnormal_ependyma_morphology1.88170491
17MP0008875_abnormal_xenobiotic_pharmacok1.77009952
18MP0005645_abnormal_hypothalamus_physiol1.72717690
19MP0005423_abnormal_somatic_nervous1.71279936
20MP0004742_abnormal_vestibular_system1.64690237
21MP0005389_reproductive_system_phenotype1.63912983
22MP0008058_abnormal_DNA_repair1.61822707
23MP0001905_abnormal_dopamine_level1.61574272
24MP0002160_abnormal_reproductive_system1.57240851
25MP0003693_abnormal_embryo_hatching1.56051003
26MP0004885_abnormal_endolymph1.53864141
27MP0008789_abnormal_olfactory_epithelium1.51533555
28MP0001919_abnormal_reproductive_system1.48297931
29MP0006276_abnormal_autonomic_nervous1.46645944
30MP0001968_abnormal_touch/_nociception1.45324156
31MP0009745_abnormal_behavioral_response1.40297455
32MP0009333_abnormal_splenocyte_physiolog1.33217899
33MP0009840_abnormal_foam_cell1.30881312
34MP0001485_abnormal_pinna_reflex1.28243522
35MP0002837_dystrophic_cardiac_calcinosis1.27929656
36MP0005646_abnormal_pituitary_gland1.26320922
37MP0005551_abnormal_eye_electrophysiolog1.26115335
38MP0002272_abnormal_nervous_system1.25247384
39MP0002210_abnormal_sex_determination1.22039172
40MP0005394_taste/olfaction_phenotype1.21279016
41MP0005499_abnormal_olfactory_system1.21279016
42MP0001440_abnormal_grooming_behavior1.19761225
43MP0002736_abnormal_nociception_after1.19582944
44MP0002163_abnormal_gland_morphology1.17932809
45MP0001835_abnormal_antigen_presentation1.17116894
46MP0003787_abnormal_imprinting1.16264059
47MP0006072_abnormal_retinal_apoptosis1.14346125
48MP0002733_abnormal_thermal_nociception1.12841286
49MP0006082_CNS_inflammation1.11469888
50MP0009046_muscle_twitch1.10330380
51MP0005167_abnormal_blood-brain_barrier1.10112868
52MP0002638_abnormal_pupillary_reflex1.09832576
53MP0003938_abnormal_ear_development1.09681472
54MP0009785_altered_susceptibility_to1.06068179
55MP0005257_abnormal_intraocular_pressure1.05905265
56MP0003137_abnormal_impulse_conducting1.05156292
57MP0002095_abnormal_skin_pigmentation1.04630945
58MP0002234_abnormal_pharynx_morphology1.04295883
59MP0002938_white_spotting1.03727314
60MP0002876_abnormal_thyroid_physiology1.03577259
61MP0001970_abnormal_pain_threshold1.02564280
62MP0001929_abnormal_gametogenesis1.02001545
63MP0002148_abnormal_hypersensitivity_rea1.01523096
64MP0003890_abnormal_embryonic-extraembry0.99601806
65MP0001873_stomach_inflammation0.97966930
66MP0006036_abnormal_mitochondrial_physio0.97877740
67MP0005410_abnormal_fertilization0.94449579
68MP0001790_abnormal_immune_system0.92752928
69MP0005387_immune_system_phenotype0.92752928
70MP0001486_abnormal_startle_reflex0.90596431
71MP0005636_abnormal_mineral_homeostasis0.90221688
72MP0006035_abnormal_mitochondrial_morpho0.88905668
73MP0002184_abnormal_innervation0.88605689
74MP0004924_abnormal_behavior0.86206894
75MP0005386_behavior/neurological_phenoty0.86206894
76MP0001119_abnormal_female_reproductive0.85382977
77MP0005670_abnormal_white_adipose0.84718763
78MP0003763_abnormal_thymus_physiology0.84180817
79MP0001502_abnormal_circadian_rhythm0.83211195
80MP0003878_abnormal_ear_physiology0.81903659
81MP0005377_hearing/vestibular/ear_phenot0.81903659
82MP0003186_abnormal_redox_activity0.80062939
83MP0001800_abnormal_humoral_immune0.79021795
84MP0003880_abnormal_central_pattern0.78514633
85MP0001984_abnormal_olfaction0.78159102
86MP0000631_abnormal_neuroendocrine_gland0.77560724
87MP0003195_calcinosis0.76870678
88MP0002277_abnormal_respiratory_mucosa0.76500664
89MP0002064_seizures0.75374405
90MP0000653_abnormal_sex_gland0.73698799
91MP0003786_premature_aging0.70919932
92MP0000049_abnormal_middle_ear0.70457692
93MP0002067_abnormal_sensory_capabilities0.69634761
94MP0000427_abnormal_hair_cycle0.69073506
95MP0001501_abnormal_sleep_pattern0.69059727
96MP0004957_abnormal_blastocyst_morpholog0.69013345
97MP0000026_abnormal_inner_ear0.68584990
98MP0001765_abnormal_ion_homeostasis0.67723811
99MP0005195_abnormal_posterior_eye0.67122765
100MP0002693_abnormal_pancreas_physiology0.65442649

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.11594446
2Breast hypoplasia (HP:0003187)4.08134496
3Acute necrotizing encephalopathy (HP:0006965)3.71096802
4Abnormality of the labia minora (HP:0012880)3.69785422
5Mitochondrial inheritance (HP:0001427)3.64618150
6Aplastic anemia (HP:0001915)3.43118804
7Abnormal mitochondria in muscle tissue (HP:0008316)3.37045803
8Microretrognathia (HP:0000308)3.30868134
9Increased CSF lactate (HP:0002490)3.26762859
10Reticulocytopenia (HP:0001896)3.26293592
11Congenital stationary night blindness (HP:0007642)3.22446013
12Hepatocellular necrosis (HP:0001404)3.17795607
13Pancreatic cysts (HP:0001737)3.06305632
14Colon cancer (HP:0003003)3.00940984
15Abnormality of midbrain morphology (HP:0002418)2.99068822
16Molar tooth sign on MRI (HP:0002419)2.99068822
17Patellar aplasia (HP:0006443)2.98923227
18Aplasia/Hypoplasia of the patella (HP:0006498)2.97262719
19Hepatic necrosis (HP:0002605)2.93942476
20Progressive macrocephaly (HP:0004481)2.93431394
213-Methylglutaconic aciduria (HP:0003535)2.85232068
22Acute encephalopathy (HP:0006846)2.81639259
23Pendular nystagmus (HP:0012043)2.81007981
24Absent thumb (HP:0009777)2.74494550
25Increased hepatocellular lipid droplets (HP:0006565)2.65962014
26Myokymia (HP:0002411)2.61129403
27Aplasia/Hypoplasia of the sternum (HP:0006714)2.60938042
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.57470697
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.57470697
30Abnormality of T cell number (HP:0011839)2.53101724
31Autoimmune thrombocytopenia (HP:0001973)2.47390937
32Abnormality of DNA repair (HP:0003254)2.46956548
33Oral leukoplakia (HP:0002745)2.46256656
34Aplasia/Hypoplasia involving the musculature (HP:0001460)2.43823650
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43459862
36Pancreatic fibrosis (HP:0100732)2.39603146
37Type II lissencephaly (HP:0007260)2.36749623
38Hypoproteinemia (HP:0003075)2.35476001
39Abnormality of cells of the erythroid lineage (HP:0012130)2.34587942
40Increased intramyocellular lipid droplets (HP:0012240)2.33566085
41Abnormality of the renal cortex (HP:0011035)2.33017472
42True hermaphroditism (HP:0010459)2.33015542
43IgG deficiency (HP:0004315)2.31032253
44Abnormality of the pons (HP:0007361)2.30510445
45Lipid accumulation in hepatocytes (HP:0006561)2.29501257
46Optic disc pallor (HP:0000543)2.29308697
47Cystic liver disease (HP:0006706)2.28708578
48Renal Fanconi syndrome (HP:0001994)2.28703048
49Exertional dyspnea (HP:0002875)2.28432627
50Stomach cancer (HP:0012126)2.27097360
51Abnormality of B cell number (HP:0010975)2.25841093
52Abnormal rod and cone electroretinograms (HP:0008323)2.20879424
53Nephronophthisis (HP:0000090)2.20195012
54Hypoplasia of the pons (HP:0012110)2.20008373
55Increased IgM level (HP:0003496)2.16978709
56Abnormality of cochlea (HP:0000375)2.10342813
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07533892
58Supernumerary spleens (HP:0009799)2.07346890
59T lymphocytopenia (HP:0005403)2.05735198
60Abnormality of magnesium homeostasis (HP:0004921)2.05418548
61Attenuation of retinal blood vessels (HP:0007843)2.05104914
62Increased serum lactate (HP:0002151)2.03946571
63Abnormality of the renal collecting system (HP:0004742)2.03441978
64Aplasia/hypoplasia of the uterus (HP:0008684)2.01986146
65Constricted visual fields (HP:0001133)2.00764993
66Abnormality of the renal medulla (HP:0100957)1.99718929
67Macrocytic anemia (HP:0001972)1.95805134
68Pancytopenia (HP:0001876)1.94666336
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90376453
70Chronic hepatic failure (HP:0100626)1.89821084
71Retinal dysplasia (HP:0007973)1.89292330
72Abnormal number of erythroid precursors (HP:0012131)1.88981807
73Abnormality of eosinophils (HP:0001879)1.88934492
74Abnormality of urine glucose concentration (HP:0011016)1.88149608
75Glycosuria (HP:0003076)1.88149608
76Autoimmune hemolytic anemia (HP:0001890)1.87869502
77Respiratory failure (HP:0002878)1.86407089
78Stenosis of the external auditory canal (HP:0000402)1.85868688
79Lactic acidosis (HP:0003128)1.85518367
80Carpal bone hypoplasia (HP:0001498)1.85501859
81Sclerocornea (HP:0000647)1.85007119
82Cerebral edema (HP:0002181)1.83993415
83Lissencephaly (HP:0001339)1.83341902
84Hypoplasia of the radius (HP:0002984)1.83159949
85Septo-optic dysplasia (HP:0100842)1.81873051
86Severe combined immunodeficiency (HP:0004430)1.81824026
87Methylmalonic acidemia (HP:0002912)1.79175475
88Absent septum pellucidum (HP:0001331)1.78840581
89Increased muscle lipid content (HP:0009058)1.78789200
90Synostosis of carpal bones (HP:0005048)1.78405142
91Abolished electroretinogram (ERG) (HP:0000550)1.77924694
92CNS demyelination (HP:0007305)1.76879202
93Congenital, generalized hypertrichosis (HP:0004540)1.76612063
94Hypomagnesemia (HP:0002917)1.76543794
95Asplenia (HP:0001746)1.74934114
96Slender long bone (HP:0003100)1.73599934
97Stomatitis (HP:0010280)1.72445369
98Abnormal ciliary motility (HP:0012262)1.71430782
99Genu varum (HP:0002970)1.70530075
100Type 2 muscle fiber atrophy (HP:0003554)1.69506486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME13.17129848
2KDR3.13809931
3WNK43.08358042
4TXK2.89279169
5PINK12.88784114
6BUB12.82628407
7BMPR1B2.77530117
8ACVR1B2.67620990
9VRK22.56863304
10TESK22.56369022
11ADRBK22.52399765
12DAPK22.46906207
13ZAK2.34611946
14CAMKK12.25916638
15CAMKK22.07987069
16GRK11.88912828
17TLK11.68404416
18MUSK1.66741673
19SRPK11.59690760
20CDC71.46319203
21MAP3K111.28791165
22MAP3K121.27741241
23STK161.26383945
24PAK61.15036930
25WNK31.14669429
26BRSK21.14352930
27DYRK21.13399538
28PLK41.12498580
29STK391.10041047
30PAK31.09609044
31FRK1.08613097
32TAOK31.07300297
33INSRR1.07184707
34BCKDK1.03627302
35CASK1.00987645
36VRK11.00963164
37PBK0.99121058
38AURKA0.98418714
39OXSR10.96586754
40PASK0.92441724
41PLK10.91714515
42GRK70.91500429
43PDK20.87676498
44CDK190.85576612
45ITK0.82737629
46BRSK10.78386702
47CAMK10.77287908
48ADRBK10.76906668
49MAPK130.75901517
50MAP4K20.73796620
51CHEK20.69064717
52WNK10.68537974
53ATR0.66303702
54CAMK2A0.65036108
55AURKB0.63839549
56LIMK10.63835251
57EPHB20.62257741
58PRKCQ0.58612623
59MAP2K60.57702626
60NUAK10.57328965
61TGFBR10.57024955
62PRKACA0.56395341
63CSNK2A10.56008037
64SYK0.55784000
65PIM10.55209340
66PHKG20.54497470
67PHKG10.54497470
68STK38L0.54125457
69CSNK1G20.53415002
70NEK20.52941556
71NTRK20.52689238
72PRKCI0.52049418
73AKT20.51946363
74CSNK1A10.51652328
75LCK0.51376888
76IKBKB0.51298540
77PRKCG0.50225089
78CSNK1G30.48797300
79LYN0.48531034
80MAP4K10.46765042
81PLK30.46519279
82TIE10.45856413
83BMX0.44930806
84CSNK2A20.44162659
85LRRK20.43395641
86PRKCA0.42847078
87PKN10.42217870
88FES0.41686679
89TEC0.41477876
90STK40.37741417
91TESK10.35955944
92EIF2AK30.35732013
93PRKCH0.35627438
94MAP2K70.34971118
95PRKCE0.34191212
96OBSCN0.33612261
97MAP3K40.33240799
98MARK30.33137741
99IKBKE0.33020509
100CSK0.32074668

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.44188996
2Oxidative phosphorylation_Homo sapiens_hsa001904.06697419
3Proteasome_Homo sapiens_hsa030503.51381384
4Parkinsons disease_Homo sapiens_hsa050123.46870771
5Homologous recombination_Homo sapiens_hsa034403.02436394
6Protein export_Homo sapiens_hsa030602.90827357
7Primary immunodeficiency_Homo sapiens_hsa053402.54509656
8Huntingtons disease_Homo sapiens_hsa050162.45782976
9Cardiac muscle contraction_Homo sapiens_hsa042602.31807548
10Alzheimers disease_Homo sapiens_hsa050102.27302696
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21850908
12RNA polymerase_Homo sapiens_hsa030202.21244680
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.12762722
14Fanconi anemia pathway_Homo sapiens_hsa034601.88977828
15Basal transcription factors_Homo sapiens_hsa030221.87693434
16Autoimmune thyroid disease_Homo sapiens_hsa053201.77192046
17Asthma_Homo sapiens_hsa053101.65727478
18DNA replication_Homo sapiens_hsa030301.64232150
19Allograft rejection_Homo sapiens_hsa053301.61216766
20Nucleotide excision repair_Homo sapiens_hsa034201.60511375
21Mismatch repair_Homo sapiens_hsa034301.54865789
22Hematopoietic cell lineage_Homo sapiens_hsa046401.54781376
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52557896
24Graft-versus-host disease_Homo sapiens_hsa053321.50949144
25Nitrogen metabolism_Homo sapiens_hsa009101.40414312
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38510564
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35618058
28Linoleic acid metabolism_Homo sapiens_hsa005911.35143228
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29325570
30RNA degradation_Homo sapiens_hsa030181.26022798
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.25613488
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25328343
33Caffeine metabolism_Homo sapiens_hsa002321.21943997
34Type I diabetes mellitus_Homo sapiens_hsa049401.18311033
35Phototransduction_Homo sapiens_hsa047441.18179235
36Pyrimidine metabolism_Homo sapiens_hsa002401.16504584
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13526510
38Antigen processing and presentation_Homo sapiens_hsa046121.12897169
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12870199
40Base excision repair_Homo sapiens_hsa034101.06699118
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99700967
42RNA transport_Homo sapiens_hsa030130.98945612
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91073688
44Nicotine addiction_Homo sapiens_hsa050330.90076871
45Chemical carcinogenesis_Homo sapiens_hsa052040.80307661
46Rheumatoid arthritis_Homo sapiens_hsa053230.78582639
47Tryptophan metabolism_Homo sapiens_hsa003800.76754435
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76362475
49beta-Alanine metabolism_Homo sapiens_hsa004100.75239310
50Regulation of autophagy_Homo sapiens_hsa041400.73274017
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72517439
52ABC transporters_Homo sapiens_hsa020100.71944168
53Butanoate metabolism_Homo sapiens_hsa006500.71837382
54Spliceosome_Homo sapiens_hsa030400.71183099
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70781380
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70571364
57T cell receptor signaling pathway_Homo sapiens_hsa046600.68907781
58Folate biosynthesis_Homo sapiens_hsa007900.67277864
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67273081
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65446498
61Collecting duct acid secretion_Homo sapiens_hsa049660.65051178
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64478379
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63782917
64Purine metabolism_Homo sapiens_hsa002300.63674784
65Steroid biosynthesis_Homo sapiens_hsa001000.61733121
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59775515
67Taste transduction_Homo sapiens_hsa047420.57513494
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55071947
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.52343910
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51307426
71Propanoate metabolism_Homo sapiens_hsa006400.50920431
72Cell cycle_Homo sapiens_hsa041100.50837257
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.50628234
74Metabolic pathways_Homo sapiens_hsa011000.50138838
75Ether lipid metabolism_Homo sapiens_hsa005650.50068808
76mRNA surveillance pathway_Homo sapiens_hsa030150.48878058
77One carbon pool by folate_Homo sapiens_hsa006700.48852533
78Olfactory transduction_Homo sapiens_hsa047400.48404694
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.43967359
80Retinol metabolism_Homo sapiens_hsa008300.42580241
81Sulfur metabolism_Homo sapiens_hsa009200.42450147
82Morphine addiction_Homo sapiens_hsa050320.42186226
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.41258134
84Peroxisome_Homo sapiens_hsa041460.38631222
85Fatty acid biosynthesis_Homo sapiens_hsa000610.37556145
86Fatty acid elongation_Homo sapiens_hsa000620.34523844
87Mineral absorption_Homo sapiens_hsa049780.34060206
88Arginine and proline metabolism_Homo sapiens_hsa003300.33738737
89Serotonergic synapse_Homo sapiens_hsa047260.33565284
90p53 signaling pathway_Homo sapiens_hsa041150.29400783
91Arachidonic acid metabolism_Homo sapiens_hsa005900.28246090
92Insulin secretion_Homo sapiens_hsa049110.27939430
93GABAergic synapse_Homo sapiens_hsa047270.26911083
94Dorso-ventral axis formation_Homo sapiens_hsa043200.25578825
95Ovarian steroidogenesis_Homo sapiens_hsa049130.25250610
96Hedgehog signaling pathway_Homo sapiens_hsa043400.25190466
97Pyruvate metabolism_Homo sapiens_hsa006200.23398428
98Vitamin digestion and absorption_Homo sapiens_hsa049770.21050917
99Oocyte meiosis_Homo sapiens_hsa041140.20603887
100Tyrosine metabolism_Homo sapiens_hsa003500.20426120

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