TCEB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)5.04866672
2proteasome assembly (GO:0043248)4.68102039
3mitotic sister chromatid cohesion (GO:0007064)4.12378389
4regulation of podosome assembly (GO:0071801)4.07823298
5negative regulation of B cell apoptotic process (GO:0002903)3.69789911
6lactate metabolic process (GO:0006089)3.65155735
7tRNA aminoacylation for protein translation (GO:0006418)3.63582208
8transcription from mitochondrial promoter (GO:0006390)3.59146393
9amino acid activation (GO:0043038)3.58257163
10tRNA aminoacylation (GO:0043039)3.58257163
11negative regulation of peptidyl-lysine acetylation (GO:2000757)3.55280784
12maturation of 5.8S rRNA (GO:0000460)3.50884073
13purine nucleobase biosynthetic process (GO:0009113)3.49311418
14synapsis (GO:0007129)3.44652791
15DNA strand elongation (GO:0022616)3.42043844
16negative regulation of histone acetylation (GO:0035067)3.42023488
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32702268
18UDP-N-acetylglucosamine metabolic process (GO:0006047)3.31861936
19IMP biosynthetic process (GO:0006188)3.27222364
20regulation of B cell apoptotic process (GO:0002902)3.26754072
21mitochondrial RNA metabolic process (GO:0000959)3.24624157
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24377108
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23683205
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20772059
25ribosome biogenesis (GO:0042254)3.15983666
26dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.15930235
27double-strand break repair via nonhomologous end joining (GO:0006303)3.15295453
28non-recombinational repair (GO:0000726)3.15295453
29mitotic metaphase plate congression (GO:0007080)3.13781967
30rRNA methylation (GO:0031167)3.12939911
31monoubiquitinated protein deubiquitination (GO:0035520)3.12369509
32neutrophil activation involved in immune response (GO:0002283)3.10795411
33telomere maintenance via semi-conservative replication (GO:0032201)3.09750647
34establishment of integrated proviral latency (GO:0075713)3.09505585
35nucleotide-sugar biosynthetic process (GO:0009226)3.08977935
36negative regulation of phagocytosis (GO:0050765)3.08007242
37dendritic cell chemotaxis (GO:0002407)3.07027663
38nucleobase biosynthetic process (GO:0046112)3.06991278
39somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.06716174
40somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.06716174
41isotype switching (GO:0045190)3.06716174
42rRNA modification (GO:0000154)3.06321922
43DNA replication initiation (GO:0006270)3.06077938
44spindle checkpoint (GO:0031577)3.05587673
45negative regulation of ligase activity (GO:0051352)3.05244771
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.05244771
47negative regulation of protein acetylation (GO:1901984)3.04194399
48cullin deneddylation (GO:0010388)3.03350812
49regulation of transcription from RNA polymerase I promoter (GO:0006356)2.97756115
50COPI coating of Golgi vesicle (GO:0048205)2.96528417
51Golgi transport vesicle coating (GO:0048200)2.96528417
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94554123
53positive regulation of protein import into nucleus, translocation (GO:0033160)2.93136485
54regulation of spindle organization (GO:0090224)2.93091042
55protein deneddylation (GO:0000338)2.92527956
56mitotic spindle checkpoint (GO:0071174)2.91857921
57IMP metabolic process (GO:0046040)2.88830075
58regulation of cellular amino acid metabolic process (GO:0006521)2.88592703
59regulation of DNA endoreduplication (GO:0032875)2.87635142
60hepatocyte apoptotic process (GO:0097284)2.86651196
61regulation of translational termination (GO:0006449)2.85420700
62regulation of interferon-beta biosynthetic process (GO:0045357)2.83400065
63attachment of spindle microtubules to kinetochore (GO:0008608)2.83022104
64positive regulation of ligase activity (GO:0051351)2.82968832
65positive regulation of interferon-alpha production (GO:0032727)2.81137917
66sister chromatid cohesion (GO:0007062)2.79963531
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79758113
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79758113
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78721050
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.78691781
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78691781
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.78691781
73DNA deamination (GO:0045006)2.78680904
74DNA replication-dependent nucleosome organization (GO:0034723)2.78540001
75DNA replication-dependent nucleosome assembly (GO:0006335)2.78540001
76regulation of ubiquitin-protein transferase activity (GO:0051438)2.78407506
77nuclear envelope organization (GO:0006998)2.78217948
78regulation of chromosome segregation (GO:0051983)2.76114396
79mitochondrial DNA metabolic process (GO:0032042)2.75864243
80spliceosomal snRNP assembly (GO:0000387)2.75372761
81positive regulation of interferon-beta production (GO:0032728)2.73760073
82signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73561513
83signal transduction involved in DNA damage checkpoint (GO:0072422)2.73561513
84protein localization to kinetochore (GO:0034501)2.72373268
85regulation of fibroblast apoptotic process (GO:2000269)2.72209933
86G1/S transition of mitotic cell cycle (GO:0000082)2.72074792
87cell cycle G1/S phase transition (GO:0044843)2.72074792
88histone H2A acetylation (GO:0043968)2.70065784
89signal transduction involved in cell cycle checkpoint (GO:0072395)2.69667490
90nucleobase-containing small molecule interconversion (GO:0015949)2.69473329
91DNA unwinding involved in DNA replication (GO:0006268)2.69457452
92regulation of ligase activity (GO:0051340)2.69309109
93regulation of translation in response to stress (GO:0043555)2.69149605
94regulation of interferon-alpha production (GO:0032647)2.67721916
95COPII vesicle coating (GO:0048208)2.67456619
96negative regulation of chromosome segregation (GO:0051985)2.65286986
97ventricular cardiac muscle cell development (GO:0055015)2.63897165
98regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.63837566
99regulation of mitotic metaphase/anaphase transition (GO:0030071)2.63837566
100protein complex localization (GO:0031503)2.63421381
101negative regulation of sister chromatid segregation (GO:0033046)2.63420936
102negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.63420936
103negative regulation of mitotic sister chromatid segregation (GO:0033048)2.63420936
104negative regulation of mast cell activation (GO:0033004)2.60703936
105establishment of chromosome localization (GO:0051303)2.58446848
106dendritic cell migration (GO:0036336)2.57896806
107metaphase plate congression (GO:0051310)2.56124234
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.55499212
109modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.55441409
110positive regulation by organism of defense response of other organism involved in symbiotic interact2.55441409
111modulation by symbiont of host immune response (GO:0052553)2.55441409
112positive regulation by symbiont of host defense response (GO:0052509)2.55441409
113modulation by symbiont of host defense response (GO:0052031)2.55441409
114modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.55441409
115leukocyte aggregation (GO:0070486)2.55092920
116mitotic chromosome condensation (GO:0007076)2.52367829
117protein localization to chromosome, centromeric region (GO:0071459)2.51990258
118nuclear pore complex assembly (GO:0051292)2.50760517
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.50273496
120regulation of dendritic cell antigen processing and presentation (GO:0002604)2.49987072
121positive regulation of antigen processing and presentation (GO:0002579)2.49885407
122positive regulation of gamma-delta T cell activation (GO:0046645)2.49593583
123regulation of mitotic spindle organization (GO:0060236)2.47640127
124natural killer cell mediated immunity (GO:0002228)2.47191126
125natural killer cell mediated cytotoxicity (GO:0042267)2.47191126
126DNA replication checkpoint (GO:0000076)2.46850761
127regulation of response to interferon-gamma (GO:0060330)2.42920746
128regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.38988691
129mitotic nuclear envelope disassembly (GO:0007077)2.38450589
130pore complex assembly (GO:0046931)2.37894631
131nuclear pore organization (GO:0006999)2.34973021
132immunoglobulin mediated immune response (GO:0016064)2.34347367
133production of molecular mediator involved in inflammatory response (GO:0002532)2.34196360
134positive regulation of organelle assembly (GO:1902117)2.29432513
135reactive oxygen species biosynthetic process (GO:1903409)2.26788212
136regulation of interferon-beta production (GO:0032648)2.25364187
137chromatin assembly (GO:0031497)2.24986974
138interferon-gamma-mediated signaling pathway (GO:0060333)2.24487249
139histone-serine phosphorylation (GO:0035404)2.23355644
140regulation of RIG-I signaling pathway (GO:0039535)2.23262487
141antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.21837800
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.21837800
143regulation of activation of Janus kinase activity (GO:0010533)2.19053834
144hydrogen peroxide biosynthetic process (GO:0050665)2.17979912
145respiratory burst (GO:0045730)2.17850412
146response to peptidoglycan (GO:0032494)2.16154277
147antigen processing and presentation of endogenous antigen (GO:0019883)2.16066751
148T cell apoptotic process (GO:0070231)2.14718125
149telomere maintenance via recombination (GO:0000722)2.14470441
150antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.12730344
151regulation of antigen processing and presentation (GO:0002577)2.11975858
152regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.11519814
1533-UTR-mediated mRNA stabilization (GO:0070935)2.10770437
154cellular response to type I interferon (GO:0071357)2.10413027
155type I interferon signaling pathway (GO:0060337)2.10413027
156myeloid dendritic cell activation (GO:0001773)2.10237058
157regulation of protein import into nucleus, translocation (GO:0033158)2.10003460
158response to type I interferon (GO:0034340)2.09998512
159nuclear envelope disassembly (GO:0051081)2.09753846
160membrane disassembly (GO:0030397)2.09753846
161neutrophil activation (GO:0042119)2.09711337
162mitotic sister chromatid segregation (GO:0000070)2.09305911
163Arp2/3 complex-mediated actin nucleation (GO:0034314)2.08914124
164positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.08098509
165positive regulation of chromosome segregation (GO:0051984)2.05792373
166granulocyte activation (GO:0036230)2.05595666
167NIK/NF-kappaB signaling (GO:0038061)2.05386377
168antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.03023548
169mitotic G2/M transition checkpoint (GO:0044818)2.02990310
170mitotic G2 DNA damage checkpoint (GO:0007095)2.02312808
171antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.01455285
172detection of molecule of bacterial origin (GO:0032490)2.00892217
173regulation of exit from mitosis (GO:0007096)2.00528915
174positive regulation of isotype switching (GO:0045830)1.99755342
175positive regulation of interleukin-8 biosynthetic process (GO:0045416)1.99577147
176sequestering of actin monomers (GO:0042989)1.99555732
177sister chromatid segregation (GO:0000819)1.99427915
178CENP-A containing nucleosome assembly (GO:0034080)1.98566230
179DNA strand elongation involved in DNA replication (GO:0006271)1.98351202
180kinetochore organization (GO:0051383)1.98345103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.03212427
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.51023904
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.39322649
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.33761935
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.86533315
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61490650
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52635851
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48734923
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.47359976
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40308260
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31961035
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23891224
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21656876
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.21129077
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18928128
16YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13013760
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.10912767
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03870555
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.02857444
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02037114
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00421119
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00393192
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.99188944
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.99042464
25PADI4_21655091_ChIP-ChIP_MCF-7_Human1.98541964
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.94754321
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89060852
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88960943
29PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.86934100
30* IRF8_27001747_Chip-Seq_BMDM_Mouse1.86681232
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86593898
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86293430
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.85302902
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84300597
35AR_21909140_ChIP-Seq_LNCAP_Human1.83723735
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80667880
37* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77749922
38* SPI1_23547873_ChIP-Seq_NB4_Human1.75136147
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75019296
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.72893184
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69962992
42TTF2_22483619_ChIP-Seq_HELA_Human1.68794174
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68622404
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68396069
45ELK1_19687146_ChIP-ChIP_HELA_Human1.63563798
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62907270
47VDR_23849224_ChIP-Seq_CD4+_Human1.60943658
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58587986
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.53435032
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51638879
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47571567
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46975144
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46222518
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.45651350
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42585517
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42243807
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41473774
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39248317
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38819213
60DCP1A_22483619_ChIP-Seq_HELA_Human1.37565162
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.35559250
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35461922
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35369156
64TFEB_21752829_ChIP-Seq_HELA_Human1.34903220
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34722539
66MYB_26560356_Chip-Seq_TH2_Human1.34019577
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32831598
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32320545
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32262870
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29128335
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.29058451
72SOX17_20123909_ChIP-Seq_XEN_Mouse1.28403828
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27745520
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26649761
75MYB_26560356_Chip-Seq_TH1_Human1.24216174
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23551953
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23251909
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22009267
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21974390
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21521469
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19635859
82XRN2_22483619_ChIP-Seq_HELA_Human1.18754669
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18724379
84* KDM5A_27292631_Chip-Seq_BREAST_Human1.18034804
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.17797766
86* MAF_26560356_Chip-Seq_TH1_Human1.15938316
87FOXP3_21729870_ChIP-Seq_TREG_Human1.15428704
88MYC_18940864_ChIP-ChIP_HL60_Human1.15036558
89* GABP_19822575_ChIP-Seq_HepG2_Human1.14381861
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.14271178
91* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14231215
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13680258
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12783626
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11721520
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11477771
96MYC_22102868_ChIP-Seq_BL_Human1.10831291
97VDR_24763502_ChIP-Seq_THP-1_Human1.10491121
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10466571
99MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10415019
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.10273628
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09016792
102MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05213816
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.04904521
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04765252
105WT1_19549856_ChIP-ChIP_CCG9911_Human1.04748899
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03408236
107ELK1_22589737_ChIP-Seq_MCF10A_Human1.03042396
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02743715
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02042815
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01235795
111MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00858384
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00204569
113* CHD1_26751641_Chip-Seq_LNCaP_Human1.00118444
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99817726
115NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99746151
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99595676
117SCL_19346495_ChIP-Seq_HPC-7_Human0.99330335
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99202110
119CLOCK_20551151_ChIP-Seq_293T_Human0.98391996
120PU_27001747_Chip-Seq_BMDM_Mouse0.97875845
121CIITA_25753668_ChIP-Seq_RAJI_Human0.96923484
122GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95970744
123* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95549648
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95051723
125BRD4_25478319_ChIP-Seq_HGPS_Human0.94458153
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93967643
127GATA3_27048872_Chip-Seq_THYMUS_Human0.93923340
128UTX_26944678_Chip-Seq_JUKART_Human0.93811345
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93509007
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91843195
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91543236
132KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91484316
133VDR_21846776_ChIP-Seq_THP-1_Human0.91368495
134GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91281836
135* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90374330
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87904058
137* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87414121
138ELF5_23300383_ChIP-Seq_T47D_Human0.86605940
139CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83972073
140POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83102056
141EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82412022
142EWS_26573619_Chip-Seq_HEK293_Human0.81345721
143CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80506888
144MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.79442599
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78877738
146* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77731842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.18204964
2MP0000372_irregular_coat_pigmentation2.79287368
3MP0003806_abnormal_nucleotide_metabolis2.77585385
4MP0003950_abnormal_plasma_membrane2.71515321
5MP0001835_abnormal_antigen_presentation2.48588873
6MP0002396_abnormal_hematopoietic_system2.30912824
7MP0003941_abnormal_skin_development2.25256894
8* MP0008007_abnormal_cellular_replicative2.22576472
9MP0003718_maternal_effect2.21590893
10MP0002877_abnormal_melanocyte_morpholog2.05812475
11MP0010307_abnormal_tumor_latency2.01567412
12MP0004233_abnormal_muscle_weight1.97199679
13MP0009333_abnormal_splenocyte_physiolog1.95467154
14MP0009785_altered_susceptibility_to1.93542114
15MP0004957_abnormal_blastocyst_morpholog1.92676277
16MP0003436_decreased_susceptibility_to1.91942430
17MP0003077_abnormal_cell_cycle1.90573606
18MP0010094_abnormal_chromosome_stability1.90198354
19MP0006054_spinal_hemorrhage1.80889898
20MP0005397_hematopoietic_system_phenotyp1.76423812
21MP0001545_abnormal_hematopoietic_system1.76423812
22MP0002419_abnormal_innate_immunity1.76197315
23MP0002148_abnormal_hypersensitivity_rea1.75080177
24MP0005671_abnormal_response_to1.72320445
25MP0005367_renal/urinary_system_phenotyp1.71651513
26MP0000516_abnormal_urinary_system1.71651513
27MP0002938_white_spotting1.70226213
28MP0008057_abnormal_DNA_replication1.69887723
29MP0003111_abnormal_nucleus_morphology1.67966225
30MP0009697_abnormal_copulation1.65708781
31MP0002452_abnormal_antigen_presenting1.62953376
32MP0003724_increased_susceptibility_to1.61432370
33MP0005000_abnormal_immune_tolerance1.58785621
34MP0005387_immune_system_phenotype1.56550620
35MP0001790_abnormal_immune_system1.56550620
36MP0000685_abnormal_immune_system1.55531287
37MP0008058_abnormal_DNA_repair1.53802038
38MP0003828_pulmonary_edema1.53409587
39MP0005025_abnormal_response_to1.52897166
40MP0004808_abnormal_hematopoietic_stem1.52111193
41MP0010352_gastrointestinal_tract_polyps1.52069136
42MP0000749_muscle_degeneration1.51422585
43MP0002723_abnormal_immune_serum1.48775192
44MP0002102_abnormal_ear_morphology1.44205031
45MP0005464_abnormal_platelet_physiology1.44160234
46MP0003786_premature_aging1.42923772
47MP0001800_abnormal_humoral_immune1.42897318
48MP0002405_respiratory_system_inflammati1.40530250
49MP0003303_peritoneal_inflammation1.39510306
50MP0001819_abnormal_immune_cell1.39497891
51MP0002420_abnormal_adaptive_immunity1.39076681
52MP0005408_hypopigmentation1.38454104
53MP0001661_extended_life_span1.36197710
54MP0003191_abnormal_cellular_cholesterol1.35023972
55MP0002398_abnormal_bone_marrow1.34385076
56MP0010234_abnormal_vibrissa_follicle1.34221228
57MP0000358_abnormal_cell_content/1.33422615
58MP0003656_abnormal_erythrocyte_physiolo1.33165210
59* MP0001697_abnormal_embryo_size1.31887515
60MP0001533_abnormal_skeleton_physiology1.31835518
61MP0004272_abnormal_basement_membrane1.31779314
62MP0002084_abnormal_developmental_patter1.30759819
63MP0000858_altered_metastatic_potential1.29081174
64MP0008438_abnormal_cutaneous_collagen1.25482282
65MP0009278_abnormal_bone_marrow1.25338618
66* MP0002080_prenatal_lethality1.24829188
67MP0000015_abnormal_ear_pigmentation1.24758857
68MP0006082_CNS_inflammation1.23860282
69* MP0002085_abnormal_embryonic_tissue1.23777390
70MP0003186_abnormal_redox_activity1.23405033
71MP0008789_abnormal_olfactory_epithelium1.20504891
72MP0002166_altered_tumor_susceptibility1.19302918
73MP0005171_absent_coat_pigmentation1.18634760
74MP0000716_abnormal_immune_system1.18433725
75MP0010155_abnormal_intestine_physiology1.16804686
76MP0000689_abnormal_spleen_morphology1.16645960
77MP0003566_abnormal_cell_adhesion1.16143611
78MP0002429_abnormal_blood_cell1.14589027
79MP0002006_tumorigenesis1.14112259
80MP0003890_abnormal_embryonic-extraembry1.13259245
81MP0002722_abnormal_immune_system1.11455198
82MP0001845_abnormal_inflammatory_respons1.11143680
83MP0005058_abnormal_lysosome_morphology1.10087660
84MP0006036_abnormal_mitochondrial_physio1.09854788
85MP0002254_reproductive_system_inflammat1.09488953
86MP0005023_abnormal_wound_healing1.09477922
87MP0006035_abnormal_mitochondrial_morpho1.07625034
88MP0003937_abnormal_limbs/digits/tail_de1.07609406
89MP0004782_abnormal_surfactant_physiolog1.07229450
90MP0005257_abnormal_intraocular_pressure1.06507239
91MP0003448_altered_tumor_morphology1.06443666
92MP0005451_abnormal_body_composition1.06304156
93MP0009840_abnormal_foam_cell1.05696134
94MP0000490_abnormal_crypts_of1.05342329
95MP0005623_abnormal_meninges_morphology1.05209328
96MP0001542_abnormal_bone_strength1.04896931
97MP0003763_abnormal_thymus_physiology1.04309757
98* MP0000350_abnormal_cell_proliferation1.03257412
99MP0000371_diluted_coat_color1.03066653
100MP0004264_abnormal_extraembryonic_tissu1.01876487
101MP0003300_gastrointestinal_ulcer1.01079103
102MP0001853_heart_inflammation1.00674947
103MP0002269_muscular_atrophy1.00197607
104MP0003755_abnormal_palate_morphology0.99176244
105MP0005621_abnormal_cell_physiology0.99052098
106MP0005075_abnormal_melanosome_morpholog0.98909410
107MP0005330_cardiomyopathy0.98570651
108MP0005395_other_phenotype0.98245805
109MP0010368_abnormal_lymphatic_system0.97251749
110MP0009703_decreased_birth_body0.96004368
111MP0005384_cellular_phenotype0.95812203
112MP0001730_embryonic_growth_arrest0.94377378
113MP0003221_abnormal_cardiomyocyte_apopto0.93699176
114MP0002160_abnormal_reproductive_system0.92936489
115MP0001299_abnormal_eye_distance/0.92561844
116MP0008469_abnormal_protein_level0.91966753
117MP0008260_abnormal_autophagy0.91766234
118MP0000343_altered_response_to0.89456641
119MP0002210_abnormal_sex_determination0.88515502
120MP0009672_abnormal_birth_weight0.88273498
121MP0002019_abnormal_tumor_incidence0.87270295
122MP0003705_abnormal_hypodermis_morpholog0.87213468
123MP0001929_abnormal_gametogenesis0.86744268
124* MP0002088_abnormal_embryonic_growth/wei0.85995670
125* MP0003984_embryonic_growth_retardation0.85767728
126MP0004947_skin_inflammation0.85560254
127MP0005390_skeleton_phenotype0.84815839
128MP0002933_joint_inflammation0.84515804
129MP0002233_abnormal_nose_morphology0.84464013
130MP0002086_abnormal_extraembryonic_tissu0.84324542
131MP0000465_gastrointestinal_hemorrhage0.83572402
132MP0005174_abnormal_tail_pigmentation0.81865987
133MP0008877_abnormal_DNA_methylation0.80609284
134MP0002837_dystrophic_cardiac_calcinosis0.79266133
135MP0002177_abnormal_outer_ear0.78424367
136MP0002095_abnormal_skin_pigmentation0.78404226
137MP0003453_abnormal_keratinocyte_physiol0.78254620
138MP0001243_abnormal_dermal_layer0.77834723
139* MP0001672_abnormal_embryogenesis/_devel0.77699650
140* MP0005380_embryogenesis_phenotype0.77699650
141MP0002060_abnormal_skin_morphology0.76734852
142MP0008932_abnormal_embryonic_tissue0.76720974
143MP0000703_abnormal_thymus_morphology0.76525711
144MP0004197_abnormal_fetal_growth/weight/0.75873304
145MP0004215_abnormal_myocardial_fiber0.74898472
146MP0004147_increased_porphyrin_level0.74861729
147MP0003567_abnormal_fetal_cardiomyocyte0.72720208
148* MP0000313_abnormal_cell_death0.72180795
149MP0000627_abnormal_mammary_gland0.71042780
150MP0001216_abnormal_epidermal_layer0.70523868
151* MP0000598_abnormal_liver_morphology0.70187645
152MP0000569_abnormal_digit_pigmentation0.70023500
153MP0010030_abnormal_orbit_morphology0.69723434
154MP0003795_abnormal_bone_structure0.69714527
155MP0003646_muscle_fatigue0.69604028
156MP0003868_abnormal_feces_composition0.69280891
157MP0003935_abnormal_craniofacial_develop0.68333649
158MP0003385_abnormal_body_wall0.68047459
159MP0003279_aneurysm0.67769561
160MP0005076_abnormal_cell_differentiation0.67744691
161MP0001849_ear_inflammation0.66947572
162MP0001186_pigmentation_phenotype0.65648958
163MP0000647_abnormal_sebaceous_gland0.65441872
164MP0002075_abnormal_coat/hair_pigmentati0.65378026
165MP0004084_abnormal_cardiac_muscle0.65185123

Predicted human phenotypes

RankGene SetZ-score
1Neoplasm of the adrenal cortex (HP:0100641)6.32258651
2Hepatoblastoma (HP:0002884)5.70865322
3Neonatal hypoglycemia (HP:0001998)5.33132034
4Diastasis recti (HP:0001540)5.21799273
5Abnormal pancreas size (HP:0012094)5.03482913
6Long foot (HP:0001833)4.84036122
7Reduced antithrombin III activity (HP:0001976)4.31328028
8Type I transferrin isoform profile (HP:0003642)4.07002576
9Acute myeloid leukemia (HP:0004808)3.73770015
10Recurrent abscess formation (HP:0002722)3.64777547
11Abnormal protein glycosylation (HP:0012346)3.60774176
12Abnormal glycosylation (HP:0012345)3.60774176
13Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.60774176
14Abnormal protein N-linked glycosylation (HP:0012347)3.60774176
15Neoplasm of the adrenal gland (HP:0100631)3.52297534
16Eczematoid dermatitis (HP:0000976)3.51600255
17Deep philtrum (HP:0002002)3.44503085
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.41889530
19Abnormal glucose tolerance (HP:0001952)3.32504193
20Abnormality of glycolysis (HP:0004366)3.32479037
21Recurrent bacterial skin infections (HP:0005406)3.24125709
22Autoimmune thrombocytopenia (HP:0001973)3.16021275
23Multiple enchondromatosis (HP:0005701)3.12316486
24Chromsome breakage (HP:0040012)3.06813767
25Increased serum pyruvate (HP:0003542)3.04864501
26Abnormality of methionine metabolism (HP:0010901)3.01399064
27Myositis (HP:0100614)2.82006458
28Meckel diverticulum (HP:0002245)2.76571283
29Secondary amenorrhea (HP:0000869)2.75930624
30Abnormality of the ileum (HP:0001549)2.75314065
31Nephroblastoma (Wilms tumor) (HP:0002667)2.71717855
32Abnormality of the preputium (HP:0100587)2.70845683
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.70223232
34High anterior hairline (HP:0009890)2.69943404
35Enlarged kidneys (HP:0000105)2.66706506
36Orchitis (HP:0100796)2.65994692
37Abnormality of chromosome stability (HP:0003220)2.62825616
38White forelock (HP:0002211)2.58353952
39Abnormal gallbladder physiology (HP:0012438)2.57600922
40Cholecystitis (HP:0001082)2.57600922
41Embryonal renal neoplasm (HP:0011794)2.54181287
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.52231003
43Osteolytic defects of the hand bones (HP:0009699)2.52231003
44Abnormality of the umbilical cord (HP:0010881)2.45921712
45Thrombocytosis (HP:0001894)2.43247086
46Shoulder girdle muscle weakness (HP:0003547)2.42787741
47Overgrowth (HP:0001548)2.42759847
48Optic neuritis (HP:0100653)2.40718186
49Retrobulbar optic neuritis (HP:0100654)2.40718186
50Volvulus (HP:0002580)2.40340224
51Abnormality of the distal phalanges of the toes (HP:0010182)2.38952932
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.38884916
53Abnormalities of placenta or umbilical cord (HP:0001194)2.38217713
54Recurrent gram-negative bacterial infections (HP:0005420)2.36629402
55Squamous cell carcinoma (HP:0002860)2.35637535
56Birth length less than 3rd percentile (HP:0003561)2.33984842
57Cutaneous melanoma (HP:0012056)2.30549916
58Poor head control (HP:0002421)2.29802899
59Delayed gross motor development (HP:0002194)2.29333102
60Ependymoma (HP:0002888)2.27835949
61Sensory axonal neuropathy (HP:0003390)2.27778862
62Abnormality of macrophages (HP:0004311)2.27371613
63Recurrent viral infections (HP:0004429)2.26340652
64Trismus (HP:0000211)2.23005593
65Degeneration of anterior horn cells (HP:0002398)2.21245816
66Abnormality of the anterior horn cell (HP:0006802)2.21245816
67Facial cleft (HP:0002006)2.20830923
68Prostate neoplasm (HP:0100787)2.17739923
69Abnormal umbilical cord blood vessels (HP:0011403)2.17391654
70Single umbilical artery (HP:0001195)2.17391654
71Abnormality of the fetal cardiovascular system (HP:0010948)2.17391654
7211 pairs of ribs (HP:0000878)2.16188571
73Progressive external ophthalmoplegia (HP:0000590)2.11294709
74Premature ovarian failure (HP:0008209)2.10813274
75Prolonged partial thromboplastin time (HP:0003645)2.10424225
76Intestinal atresia (HP:0011100)2.09919944
77Small intestinal stenosis (HP:0012848)2.09603093
78Duodenal stenosis (HP:0100867)2.09603093
79Progressive muscle weakness (HP:0003323)2.09573633
80Cortical dysplasia (HP:0002539)2.09381031
81Spastic diplegia (HP:0001264)2.08385191
82Vacuolated lymphocytes (HP:0001922)2.07250304
83Postnatal microcephaly (HP:0005484)2.06407956
84Hypoplasia of the pons (HP:0012110)2.05229694
85Recurrent fungal infections (HP:0002841)2.04927156
86Advanced eruption of teeth (HP:0006288)2.03574971
87Elevated erythrocyte sedimentation rate (HP:0003565)2.03381618
88Spontaneous hematomas (HP:0007420)2.02511147
89Spinal muscular atrophy (HP:0007269)2.02171242
90Keratoconjunctivitis sicca (HP:0001097)2.01840591
91Natal tooth (HP:0000695)2.00311979
92Carpal bone hypoplasia (HP:0001498)2.00094446
93Pustule (HP:0200039)1.98053808
94Microvesicular hepatic steatosis (HP:0001414)1.97333135
95Abnormality of the pons (HP:0007361)1.97204024
96Distal lower limb muscle weakness (HP:0009053)1.95967752
97Abnormality of the duodenum (HP:0002246)1.95906201
98Abnormality of placental membranes (HP:0011409)1.95464519
99Amniotic constriction ring (HP:0009775)1.95464519
100Gonadotropin excess (HP:0000837)1.94017589
101Mediastinal lymphadenopathy (HP:0100721)1.93885878
102Germ cell neoplasia (HP:0100728)1.90029169
103Abnormality of endocrine pancreas physiology (HP:0012093)1.89643058
104Abnormality of the pancreatic islet cells (HP:0006476)1.89643058
105Septate vagina (HP:0001153)1.89462658
106Abnormality of the fingertips (HP:0001211)1.89357660
107Eosinophilia (HP:0001880)1.88297589
108Muscle fiber splitting (HP:0003555)1.87963979
109Rimmed vacuoles (HP:0003805)1.85573277
110Horseshoe kidney (HP:0000085)1.85325338
111Breast hypoplasia (HP:0003187)1.84278400
112Abnormal foot bone ossification (HP:0010675)1.83631681
113Abnormality of the prostate (HP:0008775)1.83523332
114Petechiae (HP:0000967)1.83445649
115Cellulitis (HP:0100658)1.82803688
116Long clavicles (HP:0000890)1.81669505
117Abnormal tarsal ossification (HP:0008369)1.80749243
118Progressive inability to walk (HP:0002505)1.80357931
119Nonimmune hydrops fetalis (HP:0001790)1.80011573
120Genu varum (HP:0002970)1.79918630
121Abnormality of sulfur amino acid metabolism (HP:0004339)1.79633312
122Abnormality of DNA repair (HP:0003254)1.79468868
123Nausea (HP:0002018)1.79166970
124Abnormality of T cell physiology (HP:0011840)1.79090530
125Popliteal pterygium (HP:0009756)1.78952668
126Abnormality of the intrinsic pathway (HP:0010989)1.77932188
127Keratoconjunctivitis (HP:0001096)1.77850522
128Poikiloderma (HP:0001029)1.77413140
129Resting tremor (HP:0002322)1.77237054
130Tetraparesis (HP:0002273)1.77013927
131IgA deficiency (HP:0002720)1.76833595
132Nemaline bodies (HP:0003798)1.76167647
133Gastrointestinal infarctions (HP:0005244)1.75726797
134Cervical subluxation (HP:0003308)1.75517914
135Obstructive lung disease (HP:0006536)1.75228284
136Chronic obstructive pulmonary disease (HP:0006510)1.75228284
137Upper motor neuron abnormality (HP:0002127)1.75145315
138Vasculitis (HP:0002633)1.75131442
139Choanal atresia (HP:0000453)1.74870117
140Absent thumb (HP:0009777)1.74843315
141Ectopic kidney (HP:0000086)1.73892854
142Astrocytoma (HP:0009592)1.73158643
143Abnormality of the astrocytes (HP:0100707)1.73158643
144Flat capital femoral epiphysis (HP:0003370)1.72211027
145Osteomyelitis (HP:0002754)1.71240077
146Leukocytosis (HP:0001974)1.71110010
147Partial agenesis of the corpus callosum (HP:0001338)1.70510010
148Sloping forehead (HP:0000340)1.70507505
149Tongue fasciculations (HP:0001308)1.70248738
150Horizontal nystagmus (HP:0000666)1.69804106
151Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.69246964
152Recurrent pneumonia (HP:0006532)1.69055163
153Proximal tubulopathy (HP:0000114)1.69001719
154Granulocytopenia (HP:0001913)1.68641821
155Aplasia cutis congenita (HP:0001057)1.67538035
156Recurrent skin infections (HP:0001581)1.66578838
157Vertebral compression fractures (HP:0002953)1.66121510
158Short nail (HP:0001799)1.65576819
159Systemic lupus erythematosus (HP:0002725)1.64833284
160Clubbing of toes (HP:0100760)1.64703144
161Entropion (HP:0000621)1.64309624
162Neoplasm of the liver (HP:0002896)1.64236371
163Basal ganglia calcification (HP:0002135)1.64151497
164IgM deficiency (HP:0002850)1.63983103
165Albinism (HP:0001022)1.63600860
166Abnormal lung lobation (HP:0002101)1.63059497
167Abnormal hair whorl (HP:0010721)1.62367429
168Spinal cord lesions (HP:0100561)1.62284429
169Syringomyelia (HP:0003396)1.62284429
170Microglossia (HP:0000171)1.62098543
171Arterial thrombosis (HP:0004420)1.59511432
172Large hands (HP:0001176)1.58759730
173Abnormal gallbladder morphology (HP:0012437)1.58527909
174Submucous cleft hard palate (HP:0000176)1.58359724
175Rough bone trabeculation (HP:0100670)1.58164499
176Encephalitis (HP:0002383)1.58038279
177Hyperglycemia (HP:0003074)1.57064712
178Agnosia (HP:0010524)1.56943032
179Anorexia (HP:0002039)1.55147525
180Asymmetry of the thorax (HP:0001555)1.54302589
181Narrow palate (HP:0000189)1.53094704
182Pulmonary infiltrates (HP:0002113)1.51682903
183Premature rupture of membranes (HP:0001788)1.51394013
184Gingivitis (HP:0000230)1.51265005
185Myelodysplasia (HP:0002863)1.50560850
186Myocardial infarction (HP:0001658)1.50406764
187Abnormality of T cells (HP:0002843)1.49900033
188Patchy hypopigmentation of hair (HP:0011365)1.48711515

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK23.69221015
2STK163.04877946
3TRIM282.93819221
4NEK12.92283052
5PBK2.73731536
6PNCK2.23686834
7BUB12.22761893
8PRKG22.22757226
9PDK22.21593491
10EIF2AK12.13549872
11MKNK22.13475921
12WEE12.07594411
13STK241.94755969
14PIM21.92867399
15MAP3K141.90103243
16ZAK1.88550639
17PLK41.76701197
18MAP3K31.76309582
19MKNK11.73478936
20STK31.73305622
21STK101.71201355
22NEK91.67703722
23MAP2K31.66381579
24TYK21.64139444
25BRSK11.60083533
26TRPM71.47881910
27JAK31.42563298
28MET1.42339363
29MAP4K11.41510787
30NUAK11.38821174
31BRD41.38255001
32IRAK41.34475421
33TXK1.34376594
34TEC1.33565951
35ERBB41.31641454
36NME11.27169448
37EIF2AK31.26462686
38FRK1.26443138
39CDK81.26325737
40CDC71.24878694
41BMPR1B1.22166456
42RPS6KA41.18357632
43EPHA31.16173769
44MAPKAPK31.14355716
45STK41.12879149
46ERN11.12845225
47ZAP701.12798597
48ERBB31.10588487
49MARK31.10474307
50NME21.10307487
51TBK11.07897412
52PIM11.07734855
53TSSK61.06567704
54IRAK31.06114957
55CCNB11.05930286
56TESK11.05903346
57OBSCN1.05179428
58CHUK1.04340750
59BTK1.04318519
60EPHB11.04221640
61RIPK11.03489471
62EIF2AK21.03331640
63PLK31.01843635
64IKBKB1.00560321
65SRPK10.97793300
66AURKB0.97361437
67NEK20.95572686
68NLK0.94960078
69* ATM0.94563509
70CHEK20.92601192
71EEF2K0.91812675
72MYLK0.90616286
73TGFBR20.88449708
74LATS20.87943628
75ITK0.85772812
76CAMK1G0.85353470
77CLK10.85007953
78PTK20.83875795
79TGFBR10.83701602
80BMPR20.83604687
81PIK3CG0.82637788
82PAK40.79736410
83IKBKE0.78555494
84STK38L0.78520552
85PLK10.78134306
86AKT30.78042727
87LATS10.77891803
88PLK20.76876825
89RAF10.74031572
90MAPKAPK20.72500136
91CSNK1G10.72431284
92MST40.70927803
93MST1R0.70445246
94PRKCI0.69695097
95CDK120.68563341
96JAK10.66636322
97TTK0.66222282
98WNK30.66174801
99KIT0.64730932
100FGFR10.63823297
101BLK0.63780924
102PASK0.63274074
103RPS6KB20.60030118
104FGFR30.57060697
105CDK40.56936835
106CDK60.56749786
107FLT30.56707801
108ATR0.56256320
109TAOK30.56094198
110AKT20.52812624
111CDK10.52347839
112TTN0.50762855
113TNIK0.50723006
114FER0.50343280
115FGFR40.50162019
116CDK70.49976264
117MAP3K120.47416250
118MAP3K80.47119062
119SIK30.47083503
120CDK20.46172868
121PAK20.45878088
122CHEK10.45432827
123ACVR1B0.44047042
124SCYL20.43915040
125LYN0.42719160
126CDK90.42654773
127FGR0.42363875
128VRK20.41983442
129DYRK30.41789915
130EPHA20.41622482
131CSF1R0.41188228
132RPS6KL10.40891066
133RPS6KC10.40891066
134CSNK2A20.40809490
135KSR10.40690169
136JAK20.40528913
137ROCK20.40169105
138SYK0.39785539
139SGK20.39609999
140CSNK1E0.39429991
141PAK10.39253568
142VRK10.39251570
143CSNK2A10.37953734
144GSK3A0.37779875
145AURKA0.36642792
146CSNK1G20.36571875
147ILK0.36461763
148CSNK1G30.36270694
149ALK0.35416598
150YES10.34690527
151* PRKDC0.34558177
152CSNK1A1L0.33504974

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.46817478
2Proteasome_Homo sapiens_hsa030502.17703221
3DNA replication_Homo sapiens_hsa030302.15107482
4Cell cycle_Homo sapiens_hsa041102.11335616
5Mismatch repair_Homo sapiens_hsa034302.06742033
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.05492008
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01992092
8Leishmaniasis_Homo sapiens_hsa051402.00157246
9Vitamin B6 metabolism_Homo sapiens_hsa007501.96424097
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.96342403
11Legionellosis_Homo sapiens_hsa051341.87246284
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.85061615
13Measles_Homo sapiens_hsa051621.83897013
14RNA polymerase_Homo sapiens_hsa030201.76755615
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75622522
16Fatty acid elongation_Homo sapiens_hsa000621.73971677
17Steroid biosynthesis_Homo sapiens_hsa001001.68236513
18Herpes simplex infection_Homo sapiens_hsa051681.68173197
19Allograft rejection_Homo sapiens_hsa053301.65129804
20Antigen processing and presentation_Homo sapiens_hsa046121.63455082
21Base excision repair_Homo sapiens_hsa034101.62258180
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61534045
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57394451
24RNA transport_Homo sapiens_hsa030131.47424739
25p53 signaling pathway_Homo sapiens_hsa041151.46822624
26Pyruvate metabolism_Homo sapiens_hsa006201.44627599
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43805102
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40775608
29Influenza A_Homo sapiens_hsa051641.40423760
30Protein export_Homo sapiens_hsa030601.40161614
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.39669000
32African trypanosomiasis_Homo sapiens_hsa051431.37003615
33Propanoate metabolism_Homo sapiens_hsa006401.36862024
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36345620
35Graft-versus-host disease_Homo sapiens_hsa053321.34244195
36Homologous recombination_Homo sapiens_hsa034401.33405453
37Epstein-Barr virus infection_Homo sapiens_hsa051691.33292398
38N-Glycan biosynthesis_Homo sapiens_hsa005101.33033785
39Malaria_Homo sapiens_hsa051441.31381157
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29943964
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.28186577
42Nucleotide excision repair_Homo sapiens_hsa034201.27622263
43Osteoclast differentiation_Homo sapiens_hsa043801.26663069
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25423998
45Pyrimidine metabolism_Homo sapiens_hsa002401.21693739
46Non-homologous end-joining_Homo sapiens_hsa034501.21559341
47Basal transcription factors_Homo sapiens_hsa030221.21441255
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21049192
49Carbon metabolism_Homo sapiens_hsa012001.18084183
50RNA degradation_Homo sapiens_hsa030181.17446228
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17295164
52Pertussis_Homo sapiens_hsa051331.16881492
53Viral carcinogenesis_Homo sapiens_hsa052031.16685180
54Staphylococcus aureus infection_Homo sapiens_hsa051501.16374092
55One carbon pool by folate_Homo sapiens_hsa006701.15436224
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.15179542
57Biosynthesis of amino acids_Homo sapiens_hsa012301.14948206
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14631398
59Toxoplasmosis_Homo sapiens_hsa051451.13041144
60Apoptosis_Homo sapiens_hsa042101.12606559
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12566134
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12401017
63Spliceosome_Homo sapiens_hsa030401.11755263
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10734118
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09050976
66Primary immunodeficiency_Homo sapiens_hsa053401.07686573
67Sulfur metabolism_Homo sapiens_hsa009201.03682097
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00031317
69Caffeine metabolism_Homo sapiens_hsa002320.99781659
70Hepatitis B_Homo sapiens_hsa051610.98628664
71Tuberculosis_Homo sapiens_hsa051520.96637465
72Viral myocarditis_Homo sapiens_hsa054160.94429196
73Rheumatoid arthritis_Homo sapiens_hsa053230.94216894
74Oocyte meiosis_Homo sapiens_hsa041140.92974302
75Hepatitis C_Homo sapiens_hsa051600.92715324
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92640497
77Lysosome_Homo sapiens_hsa041420.92143075
78TNF signaling pathway_Homo sapiens_hsa046680.91751173
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90089383
80Hematopoietic cell lineage_Homo sapiens_hsa046400.89904729
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89357080
82Pentose phosphate pathway_Homo sapiens_hsa000300.86752230
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86668612
84Asthma_Homo sapiens_hsa053100.86378848
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.84935680
86Shigellosis_Homo sapiens_hsa051310.84895148
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83956519
88Phagosome_Homo sapiens_hsa041450.83261717
89beta-Alanine metabolism_Homo sapiens_hsa004100.81583410
90Fanconi anemia pathway_Homo sapiens_hsa034600.77909464
91Autoimmune thyroid disease_Homo sapiens_hsa053200.77251958
92Circadian rhythm_Homo sapiens_hsa047100.77144334
93Small cell lung cancer_Homo sapiens_hsa052220.75948724
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75313082
95Fatty acid metabolism_Homo sapiens_hsa012120.72843668
96Type I diabetes mellitus_Homo sapiens_hsa049400.72725946
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72714261
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.72291033
99Glutathione metabolism_Homo sapiens_hsa004800.72216581
100Fructose and mannose metabolism_Homo sapiens_hsa000510.70223846
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70106188
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69513134
103Other glycan degradation_Homo sapiens_hsa005110.68284445
104Fatty acid degradation_Homo sapiens_hsa000710.68142618
105Amoebiasis_Homo sapiens_hsa051460.67855459
106Sphingolipid metabolism_Homo sapiens_hsa006000.67649354
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66747748
108TGF-beta signaling pathway_Homo sapiens_hsa043500.65864887
109MicroRNAs in cancer_Homo sapiens_hsa052060.65337429
110HTLV-I infection_Homo sapiens_hsa051660.64916452
111Systemic lupus erythematosus_Homo sapiens_hsa053220.64911225
112Salmonella infection_Homo sapiens_hsa051320.63784929
113Lysine degradation_Homo sapiens_hsa003100.63599337
114Chronic myeloid leukemia_Homo sapiens_hsa052200.62586007
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62084073
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61087772
117B cell receptor signaling pathway_Homo sapiens_hsa046620.61073861
118Regulation of autophagy_Homo sapiens_hsa041400.60679362
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.60390040
120Selenocompound metabolism_Homo sapiens_hsa004500.59503558
121Thyroid cancer_Homo sapiens_hsa052160.59111097
122Chemokine signaling pathway_Homo sapiens_hsa040620.57403038
123Arginine and proline metabolism_Homo sapiens_hsa003300.57350637
124Prostate cancer_Homo sapiens_hsa052150.56827067
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54944385
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54522477
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54170460
128Pancreatic cancer_Homo sapiens_hsa052120.51731838
129Platelet activation_Homo sapiens_hsa046110.51646736
130Prolactin signaling pathway_Homo sapiens_hsa049170.51111475
131Adherens junction_Homo sapiens_hsa045200.49415337
132Folate biosynthesis_Homo sapiens_hsa007900.48955125
133mRNA surveillance pathway_Homo sapiens_hsa030150.47385349
134Purine metabolism_Homo sapiens_hsa002300.46858982
135Metabolic pathways_Homo sapiens_hsa011000.45339503
136Galactose metabolism_Homo sapiens_hsa000520.44386409
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.44363543
138FoxO signaling pathway_Homo sapiens_hsa040680.44190912
139Arginine biosynthesis_Homo sapiens_hsa002200.43205921
140Butanoate metabolism_Homo sapiens_hsa006500.38623422
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38033916
142Vibrio cholerae infection_Homo sapiens_hsa051100.37510769
143Proteoglycans in cancer_Homo sapiens_hsa052050.37316530
144Primary bile acid biosynthesis_Homo sapiens_hsa001200.36882546
145Tyrosine metabolism_Homo sapiens_hsa003500.35581013
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33100367
147Bladder cancer_Homo sapiens_hsa052190.29203607
148Tight junction_Homo sapiens_hsa045300.25262913
149Tryptophan metabolism_Homo sapiens_hsa003800.23807614
150Huntingtons disease_Homo sapiens_hsa050160.21272551
151Hippo signaling pathway_Homo sapiens_hsa043900.18323155
152Peroxisome_Homo sapiens_hsa041460.16447324
153Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16298418

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