TCEB3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.60939278
2plasma membrane fusion (GO:0045026)9.39296680
3microtubule depolymerization (GO:0007019)9.13716225
4DNA packaging (GO:0006323)9.06937567
5sperm capacitation (GO:0048240)9.03685427
6spermatid nucleus differentiation (GO:0007289)7.92759456
7single strand break repair (GO:0000012)7.80239924
8spermatid development (GO:0007286)7.72161003
9sperm-egg recognition (GO:0035036)7.57924710
10microtubule polymerization or depolymerization (GO:0031109)7.27664985
11binding of sperm to zona pellucida (GO:0007339)7.16091310
12negative regulation of inclusion body assembly (GO:0090084)6.97189815
13multicellular organism reproduction (GO:0032504)6.94432664
14calcium ion-dependent exocytosis (GO:0017156)6.73711086
15rRNA methylation (GO:0031167)6.67714679
16reproduction (GO:0000003)6.60174832
17sexual reproduction (GO:0019953)6.56942281
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.43036830
19protein targeting to Golgi (GO:0000042)6.36874220
20establishment of protein localization to Golgi (GO:0072600)6.21489479
21cell-cell recognition (GO:0009988)6.21228076
22protein polyglutamylation (GO:0018095)6.17368987
23cellular ketone body metabolic process (GO:0046950)6.12694650
24spermatogenesis (GO:0007283)6.01336389
25male gamete generation (GO:0048232)5.99315734
26retrograde transport, vesicle recycling within Golgi (GO:0000301)5.93779154
27axonemal dynein complex assembly (GO:0070286)5.85871466
28phosphatidylethanolamine biosynthetic process (GO:0006646)5.68624262
29rRNA modification (GO:0000154)5.60072713
30gamete generation (GO:0007276)5.47163133
31ketone body metabolic process (GO:1902224)5.40712103
32centriole replication (GO:0007099)5.38128625
33positive regulation of Rab GTPase activity (GO:0032851)5.29954152
34regulation of Rab GTPase activity (GO:0032313)5.29954152
35phosphatidylethanolamine metabolic process (GO:0046337)5.29398551
36microtubule severing (GO:0051013)5.20882663
37motile cilium assembly (GO:0044458)4.95084484
38chromatin silencing (GO:0006342)4.89391447
39regulation of inclusion body assembly (GO:0090083)4.84428633
40single fertilization (GO:0007338)4.79237624
41centriole assembly (GO:0098534)4.66351951
42protein localization to Golgi apparatus (GO:0034067)4.56922413
43regulation of transcription involved in cell fate commitment (GO:0060850)4.47431531
44coenzyme catabolic process (GO:0009109)4.45220177
45regulation of centriole replication (GO:0046599)4.43177725
46regulation of cilium movement (GO:0003352)4.42962934
47cilium or flagellum-dependent cell motility (GO:0001539)4.42624129
48multicellular organismal reproductive process (GO:0048609)4.35618438
49germ cell development (GO:0007281)4.34692605
50cellular process involved in reproduction in multicellular organism (GO:0022412)4.21994565
51seminiferous tubule development (GO:0072520)4.09887948
52cell wall macromolecule catabolic process (GO:0016998)4.03430926
53glycerol ether metabolic process (GO:0006662)3.98864691
54RNA destabilization (GO:0050779)3.91707354
55negative regulation of Rho protein signal transduction (GO:0035024)3.89545062
56fertilization (GO:0009566)3.88090128
57cell wall macromolecule metabolic process (GO:0044036)3.85658362
58nucleus organization (GO:0006997)3.79630704
59ether metabolic process (GO:0018904)3.67606020
60epithelial cilium movement (GO:0003351)3.61808174
61cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.55929257
62multicellular organismal movement (GO:0050879)3.52250442
63musculoskeletal movement (GO:0050881)3.52250442
64cell differentiation involved in metanephros development (GO:0072202)3.50276731
65mesenchymal cell differentiation involved in renal system development (GO:2001012)3.48109764
66mesenchymal cell differentiation involved in kidney development (GO:0072161)3.48109764
67glomerular visceral epithelial cell development (GO:0072015)3.43123509
68negative regulation of gene expression, epigenetic (GO:0045814)3.40809904
69protein depolymerization (GO:0051261)3.38199299
70glomerular epithelial cell development (GO:0072310)3.35759481
71cilium movement (GO:0003341)3.32958094
72peptidyl-threonine dephosphorylation (GO:0035970)3.31612785
73NAD biosynthetic process (GO:0009435)3.23051355
74organic cation transport (GO:0015695)3.15505431
75histone H3-K9 demethylation (GO:0033169)3.14815565
76cerebral cortex neuron differentiation (GO:0021895)3.14473183
77cellular response to pH (GO:0071467)3.05972291
78cranial nerve morphogenesis (GO:0021602)3.04674825
79response to acidic pH (GO:0010447)3.04553953
80polyamine biosynthetic process (GO:0006596)3.00537625
81detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.99928795
82metanephric mesenchyme development (GO:0072075)2.98192795
83cell recognition (GO:0008037)2.97556215
84metanephric tubule development (GO:0072170)2.93698950
85metanephric nephron tubule development (GO:0072234)2.93698950
86nucleosome disassembly (GO:0006337)2.91777259
87protein-DNA complex disassembly (GO:0032986)2.91777259
88membrane protein intracellular domain proteolysis (GO:0031293)2.89447077
89DNA conformation change (GO:0071103)2.88682700
90negative regulation of histone methylation (GO:0031061)2.88199126
91regulation of interleukin-13 production (GO:0032656)2.86273290
92negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.84271719
93homeostasis of number of cells within a tissue (GO:0048873)2.81347888
94regulation of T-helper 2 cell differentiation (GO:0045628)2.80980529
95multicellular organismal development (GO:0007275)2.80525241
96pattern specification involved in kidney development (GO:0061004)2.80237332
97fusion of sperm to egg plasma membrane (GO:0007342)12.3850577
98acrosome reaction (GO:0007340)12.2052735
99sperm motility (GO:0030317)11.1305901
100response to pheromone (GO:0019236)10.0887104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.29588502
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.02984327
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.84929801
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45639798
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.45639798
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26333142
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.20908741
8CBP_20019798_ChIP-Seq_JUKART_Human2.20908741
9ELF1_20517297_ChIP-Seq_JURKAT_Human2.11565322
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08124500
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.01784619
12EZH2_22144423_ChIP-Seq_EOC_Human2.00372566
13ERA_21632823_ChIP-Seq_H3396_Human2.00160322
14DROSHA_22980978_ChIP-Seq_HELA_Human1.97994484
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94033616
16RAC3_21632823_ChIP-Seq_H3396_Human1.92906619
17WDR5_24793694_ChIP-Seq_LNCAP_Human1.92636644
18EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.87093299
19RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.82817246
20FUS_26573619_Chip-Seq_HEK293_Human1.82622050
21NANOG_20526341_ChIP-Seq_ESCs_Human1.80092026
22TDRD3_21172665_ChIP-Seq_MCF-7_Human1.78461533
23UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77198235
24CTCF_27219007_Chip-Seq_Bcells_Human1.76648614
25EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.73583938
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71122196
27ER_23166858_ChIP-Seq_MCF-7_Human1.67430072
28TAF2_19829295_ChIP-Seq_ESCs_Human1.65024454
29E2F1_20622854_ChIP-Seq_HELA_Human1.64213550
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58889224
31SMC4_20622854_ChIP-Seq_HELA_Human1.58217493
32PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.56273183
33* BCL6_27268052_Chip-Seq_Bcells_Human1.55008533
34AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53507070
35* MYC_19829295_ChIP-Seq_ESCs_Human1.53260961
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.50834303
37YY1_22570637_ChIP-Seq_MALME-3M_Human1.48504771
38TAF15_26573619_Chip-Seq_HEK293_Human1.47977847
39TP63_22573176_ChIP-Seq_HFKS_Human1.47649053
40PHF8_20622854_ChIP-Seq_HELA_Human1.47287379
41CTCF_20526341_ChIP-Seq_ESCs_Human1.46747371
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46308757
43TP53_18474530_ChIP-ChIP_U2OS_Human1.45308716
44P68_20966046_ChIP-Seq_HELA_Human1.44571209
45* SMAD4_21741376_ChIP-Seq_EPCs_Human1.43736761
46OCT4_20526341_ChIP-Seq_ESCs_Human1.42766376
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41817639
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.41683512
49HNFA_21074721_ChIP-Seq_CACO-2_Human1.40116947
50AR_25329375_ChIP-Seq_VCAP_Human1.39681893
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39074537
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38404219
53* BCOR_27268052_Chip-Seq_Bcells_Human1.35295592
54CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.34461562
55CBX2_22325352_ChIP-Seq_293T-Rex_Human1.34325582
56P300_27268052_Chip-Seq_Bcells_Human1.33438280
57LXR_22292898_ChIP-Seq_THP-1_Human1.32798216
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32319361
59SMAD3_21741376_ChIP-Seq_ESCs_Human1.31861489
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.29852076
61RBPJ_21746931_ChIP-Seq_IB4_Human1.29217004
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28062520
63KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.26336943
64ETV1_20927104_ChIP-Seq_GIST48_Human1.26176908
65CEBPB_22108803_ChIP-Seq_LS180_Human1.24451834
66RUNX_20019798_ChIP-Seq_JUKART_Human1.24206151
67NFYB_21822215_ChIP-Seq_K562_Human1.22226345
68TBL1_22424771_ChIP-Seq_293T_Human1.21274522
69ERG_20517297_ChIP-Seq_VCAP_Human1.21157455
70P300_19829295_ChIP-Seq_ESCs_Human1.20935228
71SMAD4_21741376_ChIP-Seq_HESCs_Human1.19098651
72P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.18568086
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18419972
74SOX2_22085726_ChIP-Seq_NPCs_Mouse1.18271393
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17972114
76ZNF274_21170338_ChIP-Seq_K562_Hela1.16446767
77* P53_21459846_ChIP-Seq_SAOS-2_Human1.15593315
78PHF8_20622853_ChIP-Seq_HELA_Human1.15049658
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14143148
80SA1_27219007_Chip-Seq_Bcells_Human1.13116582
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12837041
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.11481010
83HOXB7_26014856_ChIP-Seq_BT474_Human1.11311118
84GATA6_21074721_ChIP-Seq_CACO-2_Human1.10325238
85RUNX2_22187159_ChIP-Seq_PCA_Human1.09814860
86VDR_22108803_ChIP-Seq_LS180_Human1.09787613
87E2F1_17053090_ChIP-ChIP_MCF-7_Human1.08911002
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06516860
89SMRT_27268052_Chip-Seq_Bcells_Human1.06481233
90AR_21572438_ChIP-Seq_LNCaP_Human1.05219796
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.04970883
92NANOG_19829295_ChIP-Seq_ESCs_Human1.04963988
93SOX2_19829295_ChIP-Seq_ESCs_Human1.04963988
94* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04133484
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02124059
96NFYA_21822215_ChIP-Seq_K562_Human1.01235935
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00804095
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00509725
99OCT1_27270436_Chip-Seq_PROSTATE_Human1.00001121
100RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99852636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology4.94841955
2MP0005377_hearing/vestibular/ear_phenot4.94841955
3MP0003698_abnormal_male_reproductive4.32576348
4MP0005670_abnormal_white_adipose4.24519250
5MP0001929_abnormal_gametogenesis3.70021787
6MP0001348_abnormal_lacrimal_gland3.55736059
7MP0000678_abnormal_parathyroid_gland2.70072586
8MP0003011_delayed_dark_adaptation2.60034782
9MP0002161_abnormal_fertility/fecundity2.39189063
10MP0003646_muscle_fatigue2.23129332
11MP0002132_abnormal_respiratory_system2.10700450
12MP0003718_maternal_effect2.05421022
13MP0005410_abnormal_fertilization12.0186983
14MP0002249_abnormal_larynx_morphology1.99621219
15MP0005451_abnormal_body_composition1.91833729
16MP0001485_abnormal_pinna_reflex1.89013307
17MP0002234_abnormal_pharynx_morphology1.86103141
18MP0005379_endocrine/exocrine_gland_phen1.84227140
19MP0004510_myositis1.82456637
20MP0001486_abnormal_startle_reflex1.64695585
21MP0002282_abnormal_trachea_morphology1.62737944
22MP0005423_abnormal_somatic_nervous1.62678362
23MP0002210_abnormal_sex_determination1.54501488
24MP0004742_abnormal_vestibular_system1.50098985
25MP0002735_abnormal_chemical_nociception1.38311223
26MP0001968_abnormal_touch/_nociception1.34230064
27MP0001765_abnormal_ion_homeostasis1.33095113
28MP0002138_abnormal_hepatobiliary_system1.32375221
29MP0001145_abnormal_male_reproductive1.28636042
30MP0009053_abnormal_anal_canal1.25347558
31MP0000653_abnormal_sex_gland1.22491132
32MP0005310_abnormal_salivary_gland1.21353279
33MP0001963_abnormal_hearing_physiology1.17657124
34MP0002127_abnormal_cardiovascular_syste1.13388143
35MP0004859_abnormal_synaptic_plasticity1.12736078
36MP0005248_abnormal_Harderian_gland1.11681937
37MP0000026_abnormal_inner_ear1.09915171
38MP0000534_abnormal_ureter_morphology1.08901453
39MP0003879_abnormal_hair_cell1.02856294
40MP0005395_other_phenotype1.00726073
41MP0005551_abnormal_eye_electrophysiolog0.98737338
42MP0000681_abnormal_thyroid_gland0.95537397
43MP0002733_abnormal_thermal_nociception0.93558984
44MP0000049_abnormal_middle_ear0.92317632
45MP0002822_catalepsy0.89335739
46MP0002229_neurodegeneration0.85656063
47MP0003283_abnormal_digestive_organ0.82460680
48MP0002653_abnormal_ependyma_morphology0.78905097
49MP0004085_abnormal_heartbeat0.78095087
50MP0001666_abnormal_nutrient_absorption0.76539524
51MP0002067_abnormal_sensory_capabilities0.75660709
52MP0006292_abnormal_olfactory_placode0.73334230
53MP0000955_abnormal_spinal_cord0.72588873
54MP0009115_abnormal_fat_cell0.72261894
55MP0002928_abnormal_bile_duct0.69095704
56MP0005636_abnormal_mineral_homeostasis0.65975331
57MP0008569_lethality_at_weaning0.64731736
58MP0005253_abnormal_eye_physiology0.63075337
59MP0005167_abnormal_blood-brain_barrier0.62434592
60MP0001970_abnormal_pain_threshold0.61821053
61MP0001879_abnormal_lymphatic_vessel0.61764627
62MP0008995_early_reproductive_senescence0.61548909
63MP0005083_abnormal_biliary_tract0.59995799
64MP0002572_abnormal_emotion/affect_behav0.58525287
65MP0003119_abnormal_digestive_system0.58434156
66MP0004036_abnormal_muscle_relaxation0.57744092
67MP0004233_abnormal_muscle_weight0.55697813
68MP0005623_abnormal_meninges_morphology0.55015066
69MP0001873_stomach_inflammation0.54849665
70MP0002557_abnormal_social/conspecific_i0.54835495
71MP0000470_abnormal_stomach_morphology0.53425288
72MP0001905_abnormal_dopamine_level0.52482199
73MP0001501_abnormal_sleep_pattern0.52334707
74MP0005367_renal/urinary_system_phenotyp0.51678173
75MP0000516_abnormal_urinary_system0.51678173
76MP0004484_altered_response_of0.49321994
77MP0002734_abnormal_mechanical_nocicepti0.48030014
78MP0002272_abnormal_nervous_system0.47877261
79MP0005666_abnormal_adipose_tissue0.47635173
80MP0000003_abnormal_adipose_tissue0.47473345
81MP0005084_abnormal_gallbladder_morpholo0.47379442
82MP0009697_abnormal_copulation0.47237532
83MP0001984_abnormal_olfaction0.47130555
84MP0009745_abnormal_behavioral_response0.46894648
85MP0005375_adipose_tissue_phenotype0.46635596
86MP0003137_abnormal_impulse_conducting0.46516848
87MP0005535_abnormal_body_temperature0.46129712
88MP0008961_abnormal_basal_metabolism0.44840205
89MP0000467_abnormal_esophagus_morphology0.43379182
90MP0000566_synostosis0.40192084
91MP0000230_abnormal_systemic_arterial0.40025392
92MP0001440_abnormal_grooming_behavior0.39771662
93MP0000249_abnormal_blood_vessel0.38551133
94MP0003880_abnormal_central_pattern0.37225729
95MP0010386_abnormal_urinary_bladder0.37169073
96MP0003077_abnormal_cell_cycle0.36985979
97MP0000163_abnormal_cartilage_morphology0.36128148
98MP0003699_abnormal_female_reproductive0.35453565
99MP0008877_abnormal_DNA_methylation0.34590570
100MP0002168_other_aberrant_phenotype0.34546170

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)9.30101412
2Absent/shortened dynein arms (HP:0200106)5.56328096
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.56328096
4Attenuation of retinal blood vessels (HP:0007843)5.46780670
5Bony spicule pigmentary retinopathy (HP:0007737)5.17353829
6Asymmetric septal hypertrophy (HP:0001670)5.09852870
7Hypoplastic ischia (HP:0003175)4.81265226
8Abnormal rod and cone electroretinograms (HP:0008323)4.77691439
9Bell-shaped thorax (HP:0001591)4.77500125
10Abnormal ciliary motility (HP:0012262)4.48834452
11Abnormal respiratory motile cilium physiology (HP:0012261)4.28998950
12Abnormality of the ischium (HP:0003174)4.24649062
13Enlarged epiphyses (HP:0010580)4.19395157
14Resting tremor (HP:0002322)4.16142602
15Male infertility (HP:0003251)4.06228256
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.04235066
17Abnormal respiratory motile cilium morphology (HP:0005938)3.97769446
18Abnormal respiratory epithelium morphology (HP:0012253)3.97769446
19Infertility (HP:0000789)3.85903273
20Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.83683831
21Nasal polyposis (HP:0100582)3.78689835
22Facial shape deformation (HP:0011334)3.71900429
23Potter facies (HP:0002009)3.71900429
24Hyperkalemia (HP:0002153)3.69783910
25Tubulointerstitial nephritis (HP:0001970)3.69413932
26Azoospermia (HP:0000027)3.65222268
27Chronic hepatic failure (HP:0100626)3.64273133
28Abnormality of macular pigmentation (HP:0008002)3.52628373
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.49028692
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.47353513
31Abnormal spermatogenesis (HP:0008669)3.40668094
32Impulsivity (HP:0100710)3.27191435
33Unilateral renal agenesis (HP:0000122)3.14045759
34Hypoplasia of the thymus (HP:0000778)3.10387308
35Abnormality of the aortic arch (HP:0012303)3.01782761
36Cone-rod dystrophy (HP:0000548)3.01563083
37Abnormality of the nasal mucosa (HP:0000433)3.01490455
38Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.88068047
39Absent epiphyses (HP:0010577)2.88068047
40Nephronophthisis (HP:0000090)2.78826610
41Double outlet right ventricle (HP:0001719)2.76654566
42Congenital malformation of the right heart (HP:0011723)2.76654566
43Abnormal urine output (HP:0012590)2.72780842
44Flattened epiphyses (HP:0003071)2.67877969
45Postural instability (HP:0002172)2.66366470
46Stage 5 chronic kidney disease (HP:0003774)2.59753937
47Renal dysplasia (HP:0000110)2.57654180
48Decreased central vision (HP:0007663)2.54574780
49Epiphyseal dysplasia (HP:0002656)2.51492968
50Progressive sensorineural hearing impairment (HP:0000408)2.46330504
51Rhinitis (HP:0012384)2.46030994
52Abnormality of the epiphysis of the femoral head (HP:0010574)2.45675317
53Abnormal drinking behavior (HP:0030082)2.40129827
54Polydipsia (HP:0001959)2.40129827
55Abnormality of the pubic bones (HP:0003172)2.37433927
56Abnormality of the renal medulla (HP:0100957)2.37013463
57Abnormality of potassium homeostasis (HP:0011042)2.34493739
58Abnormality of renal excretion (HP:0011036)2.33214263
59Generalized aminoaciduria (HP:0002909)2.32936609
60Abnormality of femoral epiphyses (HP:0006499)2.30248544
61Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.30248544
62Progressive cerebellar ataxia (HP:0002073)2.27492446
63Polyuria (HP:0000103)2.22803337
64Abnormality of the parathyroid morphology (HP:0011766)2.22162649
65Neoplasm of the heart (HP:0100544)2.21822969
66Amelogenesis imperfecta (HP:0000705)2.20707495
67Hypoalphalipoproteinemia (HP:0003233)2.20259169
68Abnormality of dental color (HP:0011073)2.20149560
69Flat capital femoral epiphysis (HP:0003370)2.20057574
70Abnormality of the femoral head (HP:0003368)2.17642147
71Ventricular tachycardia (HP:0004756)2.16107948
72Abnormality of the costochondral junction (HP:0000919)2.14141698
73Truncal obesity (HP:0001956)2.13735372
74Vertebral clefting (HP:0008428)2.10329825
75Pendular nystagmus (HP:0012043)2.06960055
76Portal hypertension (HP:0001409)2.01925436
77Insulin-resistant diabetes mellitus (HP:0000831)1.98129128
78Osteomalacia (HP:0002749)1.97357399
79Mixed hearing impairment (HP:0000410)1.96506665
80Tetany (HP:0001281)1.96397918
81Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95583354
82Bronchiectasis (HP:0002110)1.94431016
83Hyponatremia (HP:0002902)1.94018333
84Hypophosphatemic rickets (HP:0004912)1.92922839
85Short ribs (HP:0000773)1.90842348
86Intellectual disability, moderate (HP:0002342)1.89966950
87Tubulointerstitial abnormality (HP:0001969)1.88120623
88Chronic bronchitis (HP:0004469)1.85763177
89Widely patent fontanelles and sutures (HP:0004492)1.83583722
90Focal segmental glomerulosclerosis (HP:0000097)1.83349568
91Abnormality of the hepatic vasculature (HP:0006707)1.82945824
92Protuberant abdomen (HP:0001538)1.81334635
93Optic nerve hypoplasia (HP:0000609)1.80008778
94Sensory axonal neuropathy (HP:0003390)1.73970782
95Transposition of the great arteries (HP:0001669)1.72803006
96Abnormal connection of the cardiac segments (HP:0011545)1.72803006
97Abnormal ventriculo-arterial connection (HP:0011563)1.72803006
98Abnormality of the vertebral endplates (HP:0005106)1.71817346
99Muscle fiber atrophy (HP:0100295)1.69954499
100Hypoparathyroidism (HP:0000829)1.68906945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.07380945
2DDR25.69508220
3TESK15.57605203
4INSRR5.07587980
5MAP4K24.16623713
6BRD42.94648281
7PLK22.85156475
8STK382.66183723
9MAPK152.56602152
10PNCK2.46636406
11PRKD32.09727612
12WNK12.05518859
13PIK3CG1.89638568
14STK38L1.83731894
15CAMK1G1.77913557
16MST1R1.71899865
17CDK121.67122001
18DYRK1B1.47184655
19CDK71.40768460
20PDK11.31043472
21PDPK11.30588587
22PTK2B1.16879514
23MAP3K91.03527710
24NEK61.00532606
25BRSK20.82311630
26KSR20.80503014
27CDK40.79940301
28PRKAA20.79492903
29MAP3K110.77227949
30PRKG20.72132087
31LATS20.71399647
32MUSK0.70251781
33UHMK10.69491015
34PRKG10.65678120
35RPS6KA20.65177167
36CAMK1D0.65093421
37BMPR1B0.63481018
38ROCK10.62218158
39MAP2K20.60341402
40AKT30.58634566
41RPS6KA10.58205911
42BRSK10.49725923
43CAMK10.48835975
44PKN10.48718681
45CDK30.48621998
46FRK0.48160988
47LATS10.45429572
48MAP3K70.44332614
49BRAF0.40863700
50MAP3K80.40774614
51GSK3B0.40569759
52CAMK40.40289643
53CDK20.39293387
54LMTK20.38932684
55MTOR0.38610115
56RPS6KA60.38422053
57RPS6KL10.37987182
58RPS6KC10.37987182
59TYRO30.37942036
60MARK20.37870396
61CDK10.37227286
62MAPK10.35521722
63PRKCG0.35486107
64WNK40.35042438
65MAP3K20.34445876
66CDK80.31665785
67MAP3K40.31388397
68MAPK80.30608538
69BLK0.30234265
70PRKCZ0.30217279
71MAP3K10.27463019
72STK390.27414104
73OBSCN0.26984235
74MAPK100.26681348
75TIE10.26621478
76SGK2230.25228718
77SGK4940.25228718
78DYRK30.25086755
79CHEK10.24443109
80MARK10.24273497
81MET0.23906307
82PRKCB0.20915232
83ZAK0.19696780
84MAPK140.19330043
85AKT10.18074686
86SIK20.17149461
87SGK10.15850036
88NTRK30.14990593
89PRKACA0.14942374
90PRKCH0.14537029
91PRKAA10.12643024
92PRKACB0.12231566
93PAK20.12081663
94MAPK110.11845045
95ADRBK20.11672500
96GRK70.11268589
97IKBKB0.10032772
98ACVR1B0.08995804
99MAPK90.08580404
100RPS6KA30.07735028

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.44005019
2Fatty acid biosynthesis_Homo sapiens_hsa000614.54373943
3Olfactory transduction_Homo sapiens_hsa047404.02733650
4Butanoate metabolism_Homo sapiens_hsa006502.82732797
5Allograft rejection_Homo sapiens_hsa053302.22828891
6Autoimmune thyroid disease_Homo sapiens_hsa053202.16669726
7Type I diabetes mellitus_Homo sapiens_hsa049402.11346998
8Graft-versus-host disease_Homo sapiens_hsa053322.08691359
9Antigen processing and presentation_Homo sapiens_hsa046122.07425814
10Glycerophospholipid metabolism_Homo sapiens_hsa005642.01264968
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99834591
12Taste transduction_Homo sapiens_hsa047421.99605231
13Phenylalanine metabolism_Homo sapiens_hsa003601.71640731
14Type II diabetes mellitus_Homo sapiens_hsa049301.68951101
15Dorso-ventral axis formation_Homo sapiens_hsa043201.56732699
16Viral myocarditis_Homo sapiens_hsa054161.46398245
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43954737
18Fatty acid degradation_Homo sapiens_hsa000711.35094655
19Arginine and proline metabolism_Homo sapiens_hsa003301.27151513
20Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.22763426
21Protein digestion and absorption_Homo sapiens_hsa049741.19330433
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10237169
23Salivary secretion_Homo sapiens_hsa049701.09772045
24RNA transport_Homo sapiens_hsa030131.09732491
25Phototransduction_Homo sapiens_hsa047441.09716443
26Endocytosis_Homo sapiens_hsa041441.09545911
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08270454
28Fatty acid metabolism_Homo sapiens_hsa012121.07404985
29Cardiac muscle contraction_Homo sapiens_hsa042601.07280187
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01641904
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92856200
32cAMP signaling pathway_Homo sapiens_hsa040240.90650244
33Adipocytokine signaling pathway_Homo sapiens_hsa049200.90421372
34Maturity onset diabetes of the young_Homo sapiens_hsa049500.90389375
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90140046
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89489888
37Hedgehog signaling pathway_Homo sapiens_hsa043400.87178565
38Calcium signaling pathway_Homo sapiens_hsa040200.85407625
39Fat digestion and absorption_Homo sapiens_hsa049750.84771330
40Oocyte meiosis_Homo sapiens_hsa041140.79350572
41Influenza A_Homo sapiens_hsa051640.76535052
42Arginine biosynthesis_Homo sapiens_hsa002200.74725653
43Tyrosine metabolism_Homo sapiens_hsa003500.72433509
44PPAR signaling pathway_Homo sapiens_hsa033200.71556069
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70621493
46Renin-angiotensin system_Homo sapiens_hsa046140.70106555
47ABC transporters_Homo sapiens_hsa020100.69582904
48Morphine addiction_Homo sapiens_hsa050320.68818459
49Retinol metabolism_Homo sapiens_hsa008300.67882684
50Estrogen signaling pathway_Homo sapiens_hsa049150.66991451
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66677211
52Insulin secretion_Homo sapiens_hsa049110.65467733
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.65146230
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65127037
55Inositol phosphate metabolism_Homo sapiens_hsa005620.64247694
56Circadian entrainment_Homo sapiens_hsa047130.62424521
57Nicotine addiction_Homo sapiens_hsa050330.62236597
58Fanconi anemia pathway_Homo sapiens_hsa034600.61055610
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59268564
60Gastric acid secretion_Homo sapiens_hsa049710.58884043
61Bile secretion_Homo sapiens_hsa049760.57165521
62Glutamatergic synapse_Homo sapiens_hsa047240.55080154
63Synaptic vesicle cycle_Homo sapiens_hsa047210.54985598
64Renin secretion_Homo sapiens_hsa049240.54043369
65Glycerolipid metabolism_Homo sapiens_hsa005610.52084309
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.51986640
67Pancreatic secretion_Homo sapiens_hsa049720.50876594
68MAPK signaling pathway_Homo sapiens_hsa040100.49299230
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48399706
70Purine metabolism_Homo sapiens_hsa002300.48223249
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47706546
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44387840
73Cholinergic synapse_Homo sapiens_hsa047250.43890987
74Serotonergic synapse_Homo sapiens_hsa047260.43666915
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43211433
76Linoleic acid metabolism_Homo sapiens_hsa005910.39742796
77Oxytocin signaling pathway_Homo sapiens_hsa049210.35936076
78ECM-receptor interaction_Homo sapiens_hsa045120.34230641
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31823914
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.31778165
81Selenocompound metabolism_Homo sapiens_hsa004500.30043790
82VEGF signaling pathway_Homo sapiens_hsa043700.28825603
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.28787613
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27852756
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24805375
86Viral carcinogenesis_Homo sapiens_hsa052030.23223260
87Acute myeloid leukemia_Homo sapiens_hsa052210.23015217
88Tight junction_Homo sapiens_hsa045300.22544485
89GABAergic synapse_Homo sapiens_hsa047270.22303837
90mRNA surveillance pathway_Homo sapiens_hsa030150.22147948
91Basal transcription factors_Homo sapiens_hsa030220.21581056
92Herpes simplex infection_Homo sapiens_hsa051680.20241861
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20222017
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16381499
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16330864
96Prolactin signaling pathway_Homo sapiens_hsa049170.16059028
97Huntingtons disease_Homo sapiens_hsa050160.15202160
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14858900
99Long-term potentiation_Homo sapiens_hsa047200.14685462
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14253404

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