TCEB3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The SIII (or elongin) transcription elongation factor complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. This complex is a heterotrimer, composed of the transcriptionally active subunit A, A2 or A3 (or elongin A, A2 or A3) and two regulatory subunits, B and C (or elongin B and C). This gene encodes subunit A3. A3 and A are ubiquitously expressed, whereas A2 is specifically expressed in the testis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hippo signaling (GO:0035330)5.01224257
2interkinetic nuclear migration (GO:0022027)4.86200034
3regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.33852792
4positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.33852792
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.21078444
6negative regulation of translation, ncRNA-mediated (GO:0040033)4.21078444
7regulation of translation, ncRNA-mediated (GO:0045974)4.21078444
8regulation of female gonad development (GO:2000194)4.05521560
9regulation of pigment cell differentiation (GO:0050932)3.93394761
10monoubiquitinated protein deubiquitination (GO:0035520)3.89929517
11negative regulation of glucose import (GO:0046325)3.75143528
12negative regulation of myotube differentiation (GO:0010832)3.74187660
13urinary tract smooth muscle contraction (GO:0014848)3.70534483
14regulation of MHC class I biosynthetic process (GO:0045343)3.65744047
15regulation of skeletal muscle contraction (GO:0014819)3.55294317
16positive regulation of developmental pigmentation (GO:0048087)3.46978535
17hydrogen peroxide biosynthetic process (GO:0050665)3.45018671
18nucleus localization (GO:0051647)3.44889103
19growth hormone secretion (GO:0030252)3.42790140
20glucocorticoid receptor signaling pathway (GO:0042921)3.36729517
21regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.30597313
22positive regulation of CREB transcription factor activity (GO:0032793)3.29067233
23positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.22952645
24regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.20953075
25cardiovascular system development (GO:0072358)3.19404293
26snRNA transcription (GO:0009301)3.15620600
27regulation of establishment of cell polarity (GO:2000114)3.13935878
28negative regulation of cAMP-mediated signaling (GO:0043951)3.13022777
29positive regulation of systemic arterial blood pressure (GO:0003084)3.12544114
30positive regulation of cGMP biosynthetic process (GO:0030828)3.06851843
31indole-containing compound catabolic process (GO:0042436)3.06165482
32indolalkylamine catabolic process (GO:0046218)3.06165482
33tryptophan catabolic process (GO:0006569)3.06165482
34motile cilium assembly (GO:0044458)3.05727048
35positive regulation of digestive system process (GO:0060456)3.02719093
36endosome to melanosome transport (GO:0035646)3.00055474
37endosome to pigment granule transport (GO:0043485)3.00055474
38tryptophan metabolic process (GO:0006568)2.99549251
39endothelial cell chemotaxis (GO:0035767)2.98863120
40positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.98454927
41cilium or flagellum-dependent cell motility (GO:0001539)2.97475465
42reactive oxygen species biosynthetic process (GO:1903409)2.97175739
43cardiac myofibril assembly (GO:0055003)2.96109392
44cAMP catabolic process (GO:0006198)2.95895364
45indolalkylamine metabolic process (GO:0006586)2.95691778
46oxidative demethylation (GO:0070989)2.94637303
47negative regulation of glucose transport (GO:0010829)2.94576224
48kynurenine metabolic process (GO:0070189)2.87895365
49synaptic vesicle docking involved in exocytosis (GO:0016081)2.87766471
50regulation of cGMP biosynthetic process (GO:0030826)2.87005517
51response to misfolded protein (GO:0051788)2.86708876
52positive regulation of cation channel activity (GO:2001259)2.86117355
53SMAD protein complex assembly (GO:0007183)2.84864568
54positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.84269814
55maintenance of gastrointestinal epithelium (GO:0030277)2.81182059
56protein K48-linked deubiquitination (GO:0071108)2.79998937
57pre-miRNA processing (GO:0031054)2.78107234
58striated muscle atrophy (GO:0014891)2.77730972
59smooth muscle contraction (GO:0006939)2.76194295
60retina vasculature morphogenesis in camera-type eye (GO:0061299)2.75066963
61cyclic nucleotide catabolic process (GO:0009214)2.73198947
62corticosteroid receptor signaling pathway (GO:0031958)2.72476191
63myofibril assembly (GO:0030239)2.69703054
64natural killer cell activation involved in immune response (GO:0002323)2.69179362
65regulation of establishment or maintenance of cell polarity (GO:0032878)2.65444264
66muscle hypertrophy (GO:0014896)2.65375649
67B cell receptor signaling pathway (GO:0050853)2.62401402
68membrane depolarization during action potential (GO:0086010)2.62000799
69histone lysine methylation (GO:0034968)2.60862349
70regulation of sarcomere organization (GO:0060297)2.60569493
71negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.59768527
72neural tube development (GO:0021915)2.59505498
73regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.59377613
74negative regulation of cytosolic calcium ion concentration (GO:0051481)2.58890260
75positive regulation of cGMP metabolic process (GO:0030825)2.58084722
76positive regulation of fatty acid beta-oxidation (GO:0032000)2.54579945
77histone H3-K9 demethylation (GO:0033169)2.52963116
78lipid translocation (GO:0034204)2.50237940
79phospholipid translocation (GO:0045332)2.50237940
80positive regulation of fatty acid oxidation (GO:0046321)2.48002404
81regulation of acrosome reaction (GO:0060046)2.42003250
82muscle hypertrophy in response to stress (GO:0003299)2.40558051
83cardiac muscle adaptation (GO:0014887)2.40558051
84cardiac muscle hypertrophy in response to stress (GO:0014898)2.40558051
85muscle atrophy (GO:0014889)2.40380067
86fibroblast migration (GO:0010761)2.38928056
87negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.38912812
88NAD biosynthetic process (GO:0009435)2.37642361
89regulation of cGMP metabolic process (GO:0030823)2.37292253
90skeletal muscle adaptation (GO:0043501)2.36433619
91peptidyl-lysine dimethylation (GO:0018027)2.36118959
92positive regulation of gene expression, epigenetic (GO:0045815)2.33718669
93pericardium development (GO:0060039)2.33668468
94cellular response to ethanol (GO:0071361)2.32836795
95cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.32591847
96UDP-N-acetylglucosamine metabolic process (GO:0006047)2.32424128
97cardiac muscle hypertrophy (GO:0003300)2.32393577
98positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.32239735
99serotonin metabolic process (GO:0042428)2.31760403
100positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.30388870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.25432873
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.32275734
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.41989641
4DROSHA_22980978_ChIP-Seq_HELA_Human3.23121642
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.90736888
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.45114714
7GBX2_23144817_ChIP-Seq_PC3_Human2.32491606
8TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.12646181
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98549049
10ESR1_20079471_ChIP-ChIP_T-47D_Human1.96767129
11ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.96167958
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91346368
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.71235968
14TP53_16413492_ChIP-PET_HCT116_Human1.69946695
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67068681
16JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64944725
17AHR_22903824_ChIP-Seq_MCF-7_Human1.63971220
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56870534
19CTNNB1_20460455_ChIP-Seq_HCT116_Human1.55625186
20SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55542400
21ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51284186
22STAT3_23295773_ChIP-Seq_U87_Human1.50579543
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.46788405
24SCL_19346495_ChIP-Seq_HPC-7_Human1.46004852
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45743049
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44964902
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44361144
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.42966683
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41497579
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40856122
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40284922
32TCF4_23295773_ChIP-Seq_U87_Human1.38583704
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38576519
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37865538
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.36088812
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34612209
37VDR_22108803_ChIP-Seq_LS180_Human1.34091748
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33387643
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.33025598
40BCAT_22108803_ChIP-Seq_LS180_Human1.32252505
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.31204282
42WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29396283
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.26883846
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.26500966
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24979104
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24751007
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23062105
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.22712554
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.22645345
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.21724636
51TAF15_26573619_Chip-Seq_HEK293_Human1.19157862
52AR_21572438_ChIP-Seq_LNCaP_Human1.17545979
53AR_19668381_ChIP-Seq_PC3_Human1.17051054
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16846022
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16053269
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15183526
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15183526
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.14805866
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13764989
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12934032
61SMAD3_21741376_ChIP-Seq_HESCs_Human1.12421167
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11738042
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09937068
64SMAD4_21799915_ChIP-Seq_A2780_Human1.08665381
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07463321
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07463321
67SPI1_23127762_ChIP-Seq_K562_Human1.07002239
68SMAD4_21741376_ChIP-Seq_HESCs_Human1.05035995
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02828216
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.02337885
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.02063137
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.01251391
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00528886
74TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99725676
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98958299
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98684481
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96847912
78PRDM14_20953172_ChIP-Seq_ESCs_Human0.96580035
79SMC4_20622854_ChIP-Seq_HELA_Human0.94377140
80GATA1_19941827_ChIP-Seq_MEL_Mouse0.93069951
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92541340
82TP63_22573176_ChIP-Seq_HFKS_Human0.91569782
83REST_21632747_ChIP-Seq_MESCs_Mouse0.91353376
84TP53_23651856_ChIP-Seq_MEFs_Mouse0.91133540
85* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90622654
86OCT1_27270436_Chip-Seq_PROSTATE_Human0.90081162
87RXR_22108803_ChIP-Seq_LS180_Human0.89668371
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89204487
89CBX2_27304074_Chip-Seq_ESCs_Mouse0.88800769
90ER_23166858_ChIP-Seq_MCF-7_Human0.88683261
91CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86754901
92SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85899902
93CJUN_26792858_Chip-Seq_BT549_Human0.85566717
94OCT4_20526341_ChIP-Seq_ESCs_Human0.84212592
95MYC_22102868_ChIP-Seq_BL_Human0.83944668
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83556627
97CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82346664
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82197418
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81904169
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.81413895

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane4.01411781
2MP0010386_abnormal_urinary_bladder3.35927738
3MP0003045_fibrosis3.25977241
4MP0003183_abnormal_peptide_metabolism3.07882080
5MP0003879_abnormal_hair_cell2.80596117
6MP0002735_abnormal_chemical_nociception2.73779184
7MP0000569_abnormal_digit_pigmentation2.61511208
8MP0003252_abnormal_bile_duct2.55950060
9MP0008057_abnormal_DNA_replication2.30048947
10MP0002168_other_aberrant_phenotype2.28638756
11MP0003705_abnormal_hypodermis_morpholog2.23566248
12MP0004036_abnormal_muscle_relaxation2.19803169
13MP0002928_abnormal_bile_duct2.14532654
14MP0004043_abnormal_pH_regulation2.13984811
15MP0009384_cardiac_valve_regurgitation2.11205017
16MP0005171_absent_coat_pigmentation2.05230593
17MP0000462_abnormal_digestive_system1.99944991
18MP0003195_calcinosis1.95749157
19MP0001661_extended_life_span1.90757700
20MP0004130_abnormal_muscle_cell1.88250560
21MP0000733_abnormal_muscle_development1.85700853
22MP0000538_abnormal_urinary_bladder1.77504836
23MP0005645_abnormal_hypothalamus_physiol1.77216475
24MP0004145_abnormal_muscle_electrophysio1.75320558
25MP0002249_abnormal_larynx_morphology1.72480951
26MP0006138_congestive_heart_failure1.70868970
27MP0005670_abnormal_white_adipose1.68952137
28MP0003136_yellow_coat_color1.68648413
29MP0005076_abnormal_cell_differentiation1.67948748
30MP0003283_abnormal_digestive_organ1.60807304
31MP0004084_abnormal_cardiac_muscle1.54514032
32MP0004215_abnormal_myocardial_fiber1.50800832
33MP0008961_abnormal_basal_metabolism1.46222629
34MP0006276_abnormal_autonomic_nervous1.45613878
35MP0003137_abnormal_impulse_conducting1.45050027
36MP0001664_abnormal_digestion1.43375697
37MP0000230_abnormal_systemic_arterial1.39642474
38MP0003172_abnormal_lysosome_physiology1.32751574
39MP0005174_abnormal_tail_pigmentation1.30903707
40MP0005409_darkened_coat_color1.23860895
41MP0003279_aneurysm1.22968403
42MP0005395_other_phenotype1.22783027
43MP0002138_abnormal_hepatobiliary_system1.21221597
44MP0000747_muscle_weakness1.21043491
45MP0000751_myopathy1.19589062
46MP0001958_emphysema1.16904734
47MP0005275_abnormal_skin_tensile1.16894919
48MP0000015_abnormal_ear_pigmentation1.13442336
49MP0003646_muscle_fatigue1.13120091
50MP0003890_abnormal_embryonic-extraembry1.12029271
51MP0001849_ear_inflammation1.09450078
52MP0000026_abnormal_inner_ear1.09064453
53MP0001440_abnormal_grooming_behavior1.07080306
54MP0005620_abnormal_muscle_contractility1.06236185
55MP0001502_abnormal_circadian_rhythm1.05754302
56MP0001485_abnormal_pinna_reflex1.02522798
57MP0005646_abnormal_pituitary_gland1.00191668
58MP0003690_abnormal_glial_cell0.99533616
59MP0004085_abnormal_heartbeat0.99201310
60MP0001501_abnormal_sleep_pattern0.98967645
61MP0005503_abnormal_tendon_morphology0.96647813
62MP0005167_abnormal_blood-brain_barrier0.95890175
63MP0000428_abnormal_craniofacial_morphol0.94934632
64MP0002108_abnormal_muscle_morphology0.94683596
65MP0003091_abnormal_cell_migration0.92898584
66MP0000767_abnormal_smooth_muscle0.92341343
67MP0002396_abnormal_hematopoietic_system0.92193966
68MP0000371_diluted_coat_color0.91714495
69MP0001756_abnormal_urination0.91603868
70MP0000383_abnormal_hair_follicle0.91207139
71MP0009046_muscle_twitch0.91049454
72MP0002733_abnormal_thermal_nociception0.91044256
73MP0003959_abnormal_lean_body0.90780182
74MP0000427_abnormal_hair_cycle0.88829997
75MP0004133_heterotaxia0.86869978
76MP0005551_abnormal_eye_electrophysiolog0.86044129
77MP0003878_abnormal_ear_physiology0.84013729
78MP0005377_hearing/vestibular/ear_phenot0.84013729
79MP0003866_abnormal_defecation0.83720276
80MP0001970_abnormal_pain_threshold0.81110819
81MP0009115_abnormal_fat_cell0.80918418
82MP0002269_muscular_atrophy0.80112865
83MP0003868_abnormal_feces_composition0.79879375
84MP0001879_abnormal_lymphatic_vessel0.78760570
85MP0004381_abnormal_hair_follicle0.78011636
86MP0005330_cardiomyopathy0.77820649
87MP0005083_abnormal_biliary_tract0.77714862
88MP0002572_abnormal_emotion/affect_behav0.77175182
89MP0004233_abnormal_muscle_weight0.76794456
90MP0001963_abnormal_hearing_physiology0.75714724
91MP0010630_abnormal_cardiac_muscle0.73800466
92MP0002127_abnormal_cardiovascular_syste0.73389005
93MP0000470_abnormal_stomach_morphology0.73352575
94MP0003632_abnormal_nervous_system0.72525568
95MP0001270_distended_abdomen0.71721075
96MP0005310_abnormal_salivary_gland0.70383590
97MP0000534_abnormal_ureter_morphology0.70379898
98MP0005595_abnormal_vascular_smooth0.68672421
99MP0002067_abnormal_sensory_capabilities0.68247170
100MP0002332_abnormal_exercise_endurance0.66328591

Predicted human phenotypes

RankGene SetZ-score
1Broad face (HP:0000283)5.01226796
2Genetic anticipation (HP:0003743)4.44567634
3Hyperventilation (HP:0002883)4.13262675
4Protruding tongue (HP:0010808)3.98462114
5Dysmetric saccades (HP:0000641)3.94611431
6Aortic aneurysm (HP:0004942)3.79457182
7Lip pit (HP:0100267)3.43844248
8Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.36144843
9Obstructive sleep apnea (HP:0002870)3.27646431
10Short 4th metacarpal (HP:0010044)3.16488539
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.16488539
12Cerebral aneurysm (HP:0004944)3.12304560
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.03980965
14Abnormality of the fingertips (HP:0001211)3.01493291
15Aortic dissection (HP:0002647)3.01297402
16Aortic regurgitation (HP:0001659)2.98731660
17Cervical subluxation (HP:0003308)2.90780691
18Agammaglobulinemia (HP:0004432)2.82572109
19Progressive cerebellar ataxia (HP:0002073)2.79479641
20Urethral obstruction (HP:0000796)2.75425078
21Abnormal ciliary motility (HP:0012262)2.71703274
22Clumsiness (HP:0002312)2.67491239
23Neoplasm of the heart (HP:0100544)2.65363185
24Abnormality of the sella turcica (HP:0002679)2.63607984
25Long eyelashes (HP:0000527)2.54858892
26Cellulitis (HP:0100658)2.49658370
27Deformed sella turcica (HP:0002681)2.49043708
28Decreased circulating renin level (HP:0003351)2.48655199
29Increased cerebral lipofuscin (HP:0011813)2.48639889
30Natal tooth (HP:0000695)2.47692111
31Recurrent pneumonia (HP:0006532)2.46727187
32Spinal muscular atrophy (HP:0007269)2.44895119
33Truncal obesity (HP:0001956)2.41832541
34Ectopic kidney (HP:0000086)2.40561823
35Ureteral obstruction (HP:0006000)2.38521560
36Prolonged QT interval (HP:0001657)2.38014647
37Blue irides (HP:0000635)2.34325564
38Gaze-evoked nystagmus (HP:0000640)2.32962597
39Bronchomalacia (HP:0002780)2.27436347
40J-shaped sella turcica (HP:0002680)2.27235120
41Abnormality of the renal collecting system (HP:0004742)2.27183821
42Abnormality of the columella (HP:0009929)2.25543759
43Periauricular skin pits (HP:0100277)2.25330765
44Preauricular pit (HP:0004467)2.25330765
45Self-mutilation (HP:0000742)2.22881684
46Malnutrition (HP:0004395)2.21909495
47Congenital sensorineural hearing impairment (HP:0008527)2.21527486
48Abnormality of the nasal septum (HP:0000419)2.17175327
49Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.16853149
50Hypopigmentation of the fundus (HP:0007894)2.14369790
51Duplicated collecting system (HP:0000081)2.13213438
52Diplopia (HP:0000651)2.12577590
53Abnormality of binocular vision (HP:0011514)2.12577590
54Hypoventilation (HP:0002791)2.10588607
55Chromsome breakage (HP:0040012)2.09887510
56Narrow palate (HP:0000189)2.09559785
57Ureteral stenosis (HP:0000071)2.08470596
58Facial hemangioma (HP:0000329)2.03847541
59Impaired smooth pursuit (HP:0007772)2.03820617
60Skin pits (HP:0100276)2.03606142
61Recurrent gram-negative bacterial infections (HP:0005420)2.01640382
62Persistence of primary teeth (HP:0006335)2.01620373
63Hypoplasia of the iris (HP:0007676)2.01505939
64Neonatal hypoglycemia (HP:0001998)2.00882817
65Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00615148
66Abnormality of the 4th metacarpal (HP:0010012)1.99989962
67Aneurysm (HP:0002617)1.99542662
68Hypoplastic nipples (HP:0002557)1.99274266
69Recurrent bronchitis (HP:0002837)1.97599607
70Hyperacusis (HP:0010780)1.97509535
71Hemorrhage of the eye (HP:0011885)1.97269982
72Atrial fibrillation (HP:0005110)1.97240561
73Fair hair (HP:0002286)1.95092953
74Increased density of long bones (HP:0006392)1.90437965
75Tracheomalacia (HP:0002779)1.89912023
76Vertebral arch anomaly (HP:0008438)1.89237486
77Eczematoid dermatitis (HP:0000976)1.89214723
78Areflexia of lower limbs (HP:0002522)1.89123983
79Urinary bladder sphincter dysfunction (HP:0002839)1.85566647
80Tented upper lip vermilion (HP:0010804)1.84969395
81Syncope (HP:0001279)1.84862141
82Truncal ataxia (HP:0002078)1.83913533
83Broad metatarsal (HP:0001783)1.82273533
84Flared iliac wings (HP:0002869)1.82258904
85Recurrent lower respiratory tract infections (HP:0002783)1.79467106
86Chronic sinusitis (HP:0011109)1.79258233
87Intestinal fistula (HP:0100819)1.76195455
88Prominent nose (HP:0000448)1.76129412
89Mask-like facies (HP:0000298)1.74094373
90Renovascular hypertension (HP:0100817)1.73056489
91Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72212480
92Hypoplastic labia majora (HP:0000059)1.72106330
93Potter facies (HP:0002009)1.71397446
94Facial shape deformation (HP:0011334)1.71397446
95Laryngomalacia (HP:0001601)1.71349266
96Abnormality of the ischium (HP:0003174)1.70980980
97Stereotypic behavior (HP:0000733)1.70690951
98Abnormality of the labia majora (HP:0012881)1.70063505
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.69124870
100Osteomyelitis (HP:0002754)1.65753738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.48440947
2ACVR1B4.24198294
3TRIB34.20564765
4CDK123.76079416
5DMPK3.35580973
6MYLK3.19436620
7INSRR2.93468300
8BMPR1B2.73670551
9CAMK1D1.95104110
10ICK1.79348725
11EEF2K1.77729411
12PKN11.74230507
13TLK11.65467567
14CAMK1G1.61719371
15BLK1.56389706
16MELK1.55563055
17PKN21.44604618
18LATS11.40165289
19MTOR1.36557392
20PAK21.26994067
21MST1R1.26081533
22MAP3K71.24888990
23TTN1.24407898
24MAPK111.22437946
25WNK11.18670652
26CDC42BPA1.15964451
27KIT1.11400046
28MARK21.08003663
29WNK41.05726019
30MAPK121.01351041
31PRKCH1.01323796
32TRPM71.00501794
33ADRBK10.97656991
34MAPK150.97343043
35ILK0.94936842
36PRKAA10.93137936
37MAPKAPK30.92509948
38AKT30.91106622
39CAMK10.90039133
40SIK10.86621493
41MAP3K130.84146019
42TGFBR10.83834570
43PRKAA20.83345378
44CAMK40.81323895
45NEK20.80613799
46DDR20.79421837
47RPS6KA20.78681067
48RPS6KA60.78317513
49NTRK30.77513328
50PRKD10.76554118
51PRKD20.74231407
52BTK0.70511655
53SIK20.70309623
54MAPK130.67574836
55DAPK30.66347731
56MAP2K30.64052961
57BRD40.62242200
58RPS6KL10.61767135
59RPS6KC10.61767135
60ZAK0.60411535
61LMTK20.59411553
62MET0.58342049
63MAP2K10.56893475
64SGK20.53462487
65CAMK2G0.53366828
66ROCK10.51142384
67NTRK20.50867211
68MAPK40.49676543
69NLK0.46988915
70EPHA30.46691996
71MAPK10.46196300
72KDR0.45862616
73CDK40.45504210
74TNK20.44858734
75MAPKAPK20.44614307
76ERBB20.43168722
77NME10.42049260
78CHUK0.41394762
79PTK2B0.41130327
80CAMK2B0.40533083
81MAPK30.39269372
82RET0.38521461
83ADRBK20.36866893
84GSK3B0.36471535
85RPS6KA30.36093416
86PDGFRB0.36013099
87CAMK2A0.35360769
88CDK80.34960181
89STK390.34854537
90PRKCE0.34072095
91MAP2K60.33946799
92IKBKB0.33746850
93STK380.33116601
94PIK3CA0.32642245
95AKT10.31487622
96PRKCZ0.31325238
97PDGFRA0.31148942
98RPS6KB20.31008782
99RPS6KA50.30983918
100CSF1R0.30042300

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.45298635
2Systemic lupus erythematosus_Homo sapiens_hsa053222.40037719
3Vascular smooth muscle contraction_Homo sapiens_hsa042702.39989603
4Taste transduction_Homo sapiens_hsa047422.15187127
5ABC transporters_Homo sapiens_hsa020102.00018123
6Morphine addiction_Homo sapiens_hsa050321.69885145
7Phosphatidylinositol signaling system_Homo sapiens_hsa040701.57827895
8ECM-receptor interaction_Homo sapiens_hsa045121.54629302
9Dilated cardiomyopathy_Homo sapiens_hsa054141.50481642
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49372059
11Homologous recombination_Homo sapiens_hsa034401.49067346
12B cell receptor signaling pathway_Homo sapiens_hsa046621.48577615
13Circadian entrainment_Homo sapiens_hsa047131.44822334
14Cholinergic synapse_Homo sapiens_hsa047251.40351351
15Alcoholism_Homo sapiens_hsa050341.39847710
16Serotonergic synapse_Homo sapiens_hsa047261.39303755
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36925924
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34169230
19cGMP-PKG signaling pathway_Homo sapiens_hsa040221.32774120
20Calcium signaling pathway_Homo sapiens_hsa040201.31712964
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.29746365
22Glutamatergic synapse_Homo sapiens_hsa047241.27487265
23Pancreatic secretion_Homo sapiens_hsa049721.26036414
24Platelet activation_Homo sapiens_hsa046111.25628924
25Oxytocin signaling pathway_Homo sapiens_hsa049211.25389418
26Focal adhesion_Homo sapiens_hsa045101.23839515
27Ovarian steroidogenesis_Homo sapiens_hsa049131.23538145
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20754263
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20139051
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17629311
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.17282536
32Linoleic acid metabolism_Homo sapiens_hsa005911.16209105
33Renin secretion_Homo sapiens_hsa049241.15373748
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.15308427
35GABAergic synapse_Homo sapiens_hsa047271.11305019
36Nicotine addiction_Homo sapiens_hsa050331.10731173
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09070814
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08423348
39Type II diabetes mellitus_Homo sapiens_hsa049301.05866455
40Salivary secretion_Homo sapiens_hsa049701.03601438
41Insulin secretion_Homo sapiens_hsa049111.02300097
42Gastric acid secretion_Homo sapiens_hsa049711.01284642
43Notch signaling pathway_Homo sapiens_hsa043300.99126607
44Protein digestion and absorption_Homo sapiens_hsa049740.99065861
45Bile secretion_Homo sapiens_hsa049760.97286351
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97188527
47cAMP signaling pathway_Homo sapiens_hsa040240.93366916
48Dorso-ventral axis formation_Homo sapiens_hsa043200.91289141
49Inositol phosphate metabolism_Homo sapiens_hsa005620.91269841
50Tryptophan metabolism_Homo sapiens_hsa003800.87959415
51Glycerolipid metabolism_Homo sapiens_hsa005610.87078203
52Small cell lung cancer_Homo sapiens_hsa052220.82340405
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80865799
54Staphylococcus aureus infection_Homo sapiens_hsa051500.79317083
55Asthma_Homo sapiens_hsa053100.77318399
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.74669779
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.71542141
58Choline metabolism in cancer_Homo sapiens_hsa052310.71497159
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69984943
60Viral carcinogenesis_Homo sapiens_hsa052030.68823226
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68515849
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64790953
63mTOR signaling pathway_Homo sapiens_hsa041500.63501919
64GnRH signaling pathway_Homo sapiens_hsa049120.60980028
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60344382
66Viral myocarditis_Homo sapiens_hsa054160.59847389
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59154227
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58747000
69Graft-versus-host disease_Homo sapiens_hsa053320.58616514
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56755659
71Toxoplasmosis_Homo sapiens_hsa051450.56262995
72Arachidonic acid metabolism_Homo sapiens_hsa005900.55521653
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55355619
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53791997
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53774310
76Dopaminergic synapse_Homo sapiens_hsa047280.52503364
77MicroRNAs in cancer_Homo sapiens_hsa052060.49786562
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49574309
79Pancreatic cancer_Homo sapiens_hsa052120.49106387
80Long-term depression_Homo sapiens_hsa047300.47107738
81FoxO signaling pathway_Homo sapiens_hsa040680.46604895
82Retinol metabolism_Homo sapiens_hsa008300.46392443
83Insulin resistance_Homo sapiens_hsa049310.45715844
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45419717
85Autoimmune thyroid disease_Homo sapiens_hsa053200.45347516
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44587225
87Estrogen signaling pathway_Homo sapiens_hsa049150.44581539
88Complement and coagulation cascades_Homo sapiens_hsa046100.44079666
89Chronic myeloid leukemia_Homo sapiens_hsa052200.43861135
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43176961
91Ether lipid metabolism_Homo sapiens_hsa005650.41937346
92TNF signaling pathway_Homo sapiens_hsa046680.41476477
93Allograft rejection_Homo sapiens_hsa053300.41452335
94Melanoma_Homo sapiens_hsa052180.41345363
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.40032460
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39849684
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39458833
98MAPK signaling pathway_Homo sapiens_hsa040100.38288760
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37676931
100Glioma_Homo sapiens_hsa052140.37396675

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