TCEB3CL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The SIII (or elongin) transcription elongation factor complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. This complex is a heterotrimer, composed of the transcriptionally active subunit A, A2 or A3 (or elongin A, A2 or A3) and two regulatory subunits, B and C (or elongin B and C). This gene encodes subunit A3. A3 and A are ubiquitously expressed, whereas A2 is specifically expressed in the testis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial structure maintenance (GO:0010669)8.17789575
2response to vitamin A (GO:0033189)7.35594888
3nephron epithelium morphogenesis (GO:0072088)6.35966663
4nephron tubule morphogenesis (GO:0072078)6.35966663
5cellular response to epidermal growth factor stimulus (GO:0071364)6.18219616
6O-glycan processing (GO:0016266)5.52724636
7cilium or flagellum-dependent cell motility (GO:0001539)5.16556096
8renal tubule morphogenesis (GO:0061333)5.04230443
9response to epidermal growth factor (GO:0070849)5.00135208
10protein targeting to Golgi (GO:0000042)4.73218058
11retrograde transport, vesicle recycling within Golgi (GO:0000301)4.59007195
12establishment of protein localization to Golgi (GO:0072600)4.51442539
13positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.43066480
14regulation of acrosome reaction (GO:0060046)4.26981373
15negative regulation of multicellular organism growth (GO:0040015)4.25533228
16otic vesicle formation (GO:0030916)4.11995482
17regulation of ARF GTPase activity (GO:0032312)4.11948442
18neuronal action potential (GO:0019228)4.07291898
19growth hormone secretion (GO:0030252)4.00036099
20positive regulation of digestive system process (GO:0060456)3.94520856
21negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.87998381
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87355571
23cellular anion homeostasis (GO:0030002)3.86160177
24auditory receptor cell differentiation (GO:0042491)3.84954844
25protein localization to Golgi apparatus (GO:0034067)3.81983667
26inner ear receptor cell differentiation (GO:0060113)3.77610065
27regulation of somitogenesis (GO:0014807)3.74347501
28trivalent inorganic anion homeostasis (GO:0072506)3.66395015
29phosphate ion homeostasis (GO:0055062)3.66395015
30protein O-linked glycosylation (GO:0006493)3.59999055
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48042425
32vocalization behavior (GO:0071625)3.43203586
33membrane depolarization during action potential (GO:0086010)3.40775645
34collecting duct development (GO:0072044)3.33665928
35response to lipoprotein particle (GO:0055094)3.33025994
36positive regulation of action potential (GO:0045760)3.32219017
37striated muscle atrophy (GO:0014891)3.27518616
38regulation of retinoic acid receptor signaling pathway (GO:0048385)3.25738685
39sulfate transmembrane transport (GO:1902358)3.22211861
40fucose catabolic process (GO:0019317)3.20888178
41L-fucose metabolic process (GO:0042354)3.20888178
42L-fucose catabolic process (GO:0042355)3.20888178
43negative regulation of digestive system process (GO:0060457)3.20483399
44mechanoreceptor differentiation (GO:0042490)3.18600613
45muscle atrophy (GO:0014889)3.15601020
46digestive system process (GO:0022600)3.12575510
47glucocorticoid biosynthetic process (GO:0006704)3.12463380
48C21-steroid hormone biosynthetic process (GO:0006700)3.11220733
49hair cell differentiation (GO:0035315)3.10222316
50renal system development (GO:0072001)3.00975223
51negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.98426092
52regulation of digestive system process (GO:0044058)2.97365492
53positive regulation of sodium ion transmembrane transport (GO:1902307)2.95766573
54negative regulation of smooth muscle contraction (GO:0045986)2.94233691
55regulation of mesenchymal cell apoptotic process (GO:2001053)2.91861640
56negative regulation of systemic arterial blood pressure (GO:0003085)2.88384987
57phosphate ion transmembrane transport (GO:0035435)2.84402216
58regulation of cardiac muscle cell contraction (GO:0086004)2.82871106
59dermatan sulfate metabolic process (GO:0030205)2.81453514
60regulation of hippo signaling (GO:0035330)2.79932396
61dermatan sulfate biosynthetic process (GO:0030208)2.79688685
62sulfate transport (GO:0008272)2.79238407
63pyrimidine dimer repair (GO:0006290)2.76769181
64retina vasculature morphogenesis in camera-type eye (GO:0061299)2.75853123
65somite development (GO:0061053)2.72535086
66positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.70569148
67syncytium formation (GO:0006949)2.68291132
68myoblast fusion (GO:0007520)2.66091673
69skeletal muscle adaptation (GO:0043501)2.64750780
70glomerular basement membrane development (GO:0032836)2.63780758
71lymphangiogenesis (GO:0001946)2.61547782
72cellular response to glucocorticoid stimulus (GO:0071385)2.61474954
73neuronal stem cell maintenance (GO:0097150)2.58584600
74plasma membrane repair (GO:0001778)2.56107312
75regulation of cell proliferation involved in kidney development (GO:1901722)2.54294931
76phosphate ion transport (GO:0006817)2.53046845
77urogenital system development (GO:0001655)2.52230526
78positive regulation of systemic arterial blood pressure (GO:0003084)2.50915478
79relaxation of smooth muscle (GO:0044557)2.50574543
80nephron tubule formation (GO:0072079)2.50232889
81striated muscle adaptation (GO:0014888)2.49330434
82interkinetic nuclear migration (GO:0022027)2.47848479
83calcium ion import (GO:0070509)2.47571362
84fucosylation (GO:0036065)2.46329853
85positive regulation of fatty acid oxidation (GO:0046321)2.45465017
86negative regulation of inclusion body assembly (GO:0090084)2.44643381
87mesenchymal cell differentiation involved in kidney development (GO:0072161)2.43255286
88mesenchymal cell differentiation involved in renal system development (GO:2001012)2.43255286
89neural tube development (GO:0021915)2.42581448
90macroautophagy (GO:0016236)2.42360847
91spinal cord development (GO:0021510)2.41595280
92cardiac muscle hypertrophy in response to stress (GO:0014898)2.41572571
93muscle hypertrophy in response to stress (GO:0003299)2.41572571
94cardiac muscle adaptation (GO:0014887)2.41572571
95negative regulation of Ras GTPase activity (GO:0034261)2.41081069
96bundle of His cell to Purkinje myocyte communication (GO:0086069)2.40928042
97cellular response to corticosteroid stimulus (GO:0071384)2.40125052
98regulation of endothelial cell differentiation (GO:0045601)2.39583604
99maintenance of gastrointestinal epithelium (GO:0030277)10.9770462
100regulation of G0 to G1 transition (GO:0070316)10.8543326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.14040753
2EZH2_22144423_ChIP-Seq_EOC_Human4.44957077
3CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human4.15954721
4DROSHA_22980978_ChIP-Seq_HELA_Human3.70723116
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.22691448
6GBX2_23144817_ChIP-Seq_PC3_Human3.06392446
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59255144
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.45935905
9WDR5_24793694_ChIP-Seq_LNCAP_Human2.38824524
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25115994
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.22660065
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.12997521
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.07989552
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98078558
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82831957
16TDRD3_21172665_ChIP-Seq_MCF-7_Human1.80497144
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.77107926
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73692127
19AHR_22903824_ChIP-Seq_MCF-7_Human1.73410549
20ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69512952
21VDR_22108803_ChIP-Seq_LS180_Human1.67933810
22GATA1_22025678_ChIP-Seq_K562_Human1.64767697
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64743752
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.61961800
25ER_23166858_ChIP-Seq_MCF-7_Human1.60150552
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.57822936
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57196746
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.54456922
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53983460
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53254766
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50492038
32AR_21572438_ChIP-Seq_LNCaP_Human1.50391316
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50136431
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49698108
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49698108
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.48340968
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48130335
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47464578
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45208825
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44739569
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44394218
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42765720
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41514738
44TP53_16413492_ChIP-PET_HCT116_Human1.40845014
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31707136
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.30608475
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28463240
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.28274279
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28266640
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25850265
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.22484009
52NFYA_21822215_ChIP-Seq_K562_Human1.22311408
53BCAT_22108803_ChIP-Seq_LS180_Human1.20152319
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18248199
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17809404
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.15275460
57CTCF_27219007_Chip-Seq_Bcells_Human1.15102720
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13763256
59E2F1_17053090_ChIP-ChIP_MCF-7_Human1.11603111
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11552305
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09697701
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08231900
63E2F1_20622854_ChIP-Seq_HELA_Human1.07116592
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06216572
65CBP_20019798_ChIP-Seq_JUKART_Human1.06216572
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05827124
67TP53_18474530_ChIP-ChIP_U2OS_Human1.05627661
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.04494687
69TBL1_22424771_ChIP-Seq_293T_Human1.04168980
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03789062
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03403292
72AR_25329375_ChIP-Seq_VCAP_Human1.03344108
73EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02777966
74AR_19668381_ChIP-Seq_PC3_Human1.02760907
75TCF4_23295773_ChIP-Seq_U87_Human1.02549465
76STAT3_23295773_ChIP-Seq_U87_Human1.01604040
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00982736
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00365378
79RUNX2_22187159_ChIP-Seq_PCA_Human1.00276215
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.00183445
81RNF2_27304074_Chip-Seq_NSC_Mouse0.98706258
82SOX2_21211035_ChIP-Seq_LN229_Gbm0.97399705
83SMC4_20622854_ChIP-Seq_HELA_Human0.95886002
84EP300_21415370_ChIP-Seq_HL-1_Mouse0.95664360
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95393003
86CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95282407
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94423535
88ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93175875
89NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93101424
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91100093
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90459831
92TP53_23651856_ChIP-Seq_MEFs_Mouse0.90287012
93TCF4_18268006_ChIP-ChIP_LS174T_Human0.89795101
94PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89378572
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88180157
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.88121128
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87945032
98WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87201209
99TP53_22573176_ChIP-Seq_HFKS_Human0.87030779
100RING1B_27294783_Chip-Seq_ESCs_Mouse0.86712429

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000465_gastrointestinal_hemorrhage4.27716190
2MP0001485_abnormal_pinna_reflex4.24208327
3MP0009384_cardiac_valve_regurgitation3.39143913
4MP0004043_abnormal_pH_regulation3.21911638
5MP0000579_abnormal_nail_morphology3.00480171
6MP0002102_abnormal_ear_morphology2.94829396
7MP0003879_abnormal_hair_cell2.73564701
8MP0005083_abnormal_biliary_tract2.67100427
9MP0008438_abnormal_cutaneous_collagen2.63766181
10MP0003136_yellow_coat_color2.56620038
11MP0005257_abnormal_intraocular_pressure2.44336592
12MP0002822_catalepsy2.40079347
13MP0003283_abnormal_digestive_organ2.34017085
14MP0005275_abnormal_skin_tensile2.33295230
15MP0005377_hearing/vestibular/ear_phenot2.26904986
16MP0003878_abnormal_ear_physiology2.26904986
17MP0003279_aneurysm2.26777422
18MP0004742_abnormal_vestibular_system2.24681137
19MP0003866_abnormal_defecation2.22564403
20MP0002928_abnormal_bile_duct2.07695365
21MP0001849_ear_inflammation2.07614980
22MP0000049_abnormal_middle_ear1.97556206
23MP0003705_abnormal_hypodermis_morpholog1.89994489
24MP0004133_heterotaxia1.88711415
25MP0003091_abnormal_cell_migration1.78915678
26MP0001666_abnormal_nutrient_absorption1.75567481
27MP0000026_abnormal_inner_ear1.69988477
28MP0010368_abnormal_lymphatic_system1.64373770
29MP0000749_muscle_degeneration1.60321218
30MP0002138_abnormal_hepatobiliary_system1.59156833
31MP0001963_abnormal_hearing_physiology1.58091385
32MP0000013_abnormal_adipose_tissue1.55739192
33MP0001664_abnormal_digestion1.55550383
34MP0000538_abnormal_urinary_bladder1.52735280
35MP0000383_abnormal_hair_follicle1.50735375
36MP0005171_absent_coat_pigmentation1.50354065
37MP0005503_abnormal_tendon_morphology1.49383309
38MP0001765_abnormal_ion_homeostasis1.45405935
39MP0005646_abnormal_pituitary_gland1.41058639
40MP0000566_synostosis1.40344702
41MP0003943_abnormal_hepatobiliary_system1.36577018
42MP0010030_abnormal_orbit_morphology1.33828544
43MP0005551_abnormal_eye_electrophysiolog1.29978604
44MP0008995_early_reproductive_senescence1.28471896
45MP0002249_abnormal_larynx_morphology1.27884224
46MP0002060_abnormal_skin_morphology1.26788382
47MP0003045_fibrosis1.24258648
48MP0003252_abnormal_bile_duct1.22997165
49MP0008877_abnormal_DNA_methylation1.17999051
50MP0008004_abnormal_stomach_pH1.14502733
51MP0005670_abnormal_white_adipose1.13989421
52MP0001324_abnormal_eye_pigmentation1.12007934
53MP0001661_extended_life_span1.00610573
54MP0002896_abnormal_bone_mineralization0.97941272
55MP0000647_abnormal_sebaceous_gland0.96919701
56MP0000631_abnormal_neuroendocrine_gland0.92425961
57MP0005076_abnormal_cell_differentiation0.92348460
58MP0002332_abnormal_exercise_endurance0.91963287
59MP0001270_distended_abdomen0.91670578
60MP0002160_abnormal_reproductive_system0.91191074
61MP0008872_abnormal_physiological_respon0.90975235
62MP0009250_abnormal_appendicular_skeleto0.90440023
63MP0004019_abnormal_vitamin_homeostasis0.89846504
64MP0002163_abnormal_gland_morphology0.89003098
65MP0003937_abnormal_limbs/digits/tail_de0.88741819
66MP0004272_abnormal_basement_membrane0.88709630
67MP0005187_abnormal_penis_morphology0.87484046
68MP0003183_abnormal_peptide_metabolism0.85072216
69MP0003195_calcinosis0.84357938
70MP0001243_abnormal_dermal_layer0.83912579
71MP0002116_abnormal_craniofacial_bone0.80898969
72MP0010678_abnormal_skin_adnexa0.80128077
73MP0002098_abnormal_vibrissa_morphology0.79904955
74MP0002229_neurodegeneration0.79793957
75MP0001879_abnormal_lymphatic_vessel0.79555155
76MP0001502_abnormal_circadian_rhythm0.79420935
77MP0005381_digestive/alimentary_phenotyp0.78747812
78MP0000762_abnormal_tongue_morphology0.77722745
79MP0001486_abnormal_startle_reflex0.77072018
80MP0000537_abnormal_urethra_morphology0.76511333
81MP0001663_abnormal_digestive_system0.74902222
82MP0000534_abnormal_ureter_morphology0.74523135
83MP0000427_abnormal_hair_cycle0.74389130
84MP0000372_irregular_coat_pigmentation0.71725532
85MP0005623_abnormal_meninges_morphology0.70941005
86MP0000230_abnormal_systemic_arterial0.69664353
87MP0002735_abnormal_chemical_nociception0.68974008
88MP0005367_renal/urinary_system_phenotyp0.66179522
89MP0000516_abnormal_urinary_system0.66179522
90MP0002127_abnormal_cardiovascular_syste0.65962241
91MP0000428_abnormal_craniofacial_morphol0.65749427
92MP0004145_abnormal_muscle_electrophysio0.63532597
93MP0003786_premature_aging0.63530662
94MP0005508_abnormal_skeleton_morphology0.62965845
95MP0010771_integument_phenotype0.62934915
96MP0000432_abnormal_head_morphology0.61501435
97MP0001501_abnormal_sleep_pattern0.61455395
98MP0002932_abnormal_joint_morphology0.61451850
99MP0002272_abnormal_nervous_system0.61449643
100MP0001299_abnormal_eye_distance/0.61054997

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)4.66433308
2Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.38923109
3Short 1st metacarpal (HP:0010034)4.38923109
4Abnormality of the 1st metacarpal (HP:0010009)4.09734994
5Abnormality of dentin (HP:0010299)4.04249479
6Short phalanx of the thumb (HP:0009660)4.02917353
7Congenital sensorineural hearing impairment (HP:0008527)3.91149568
8Mask-like facies (HP:0000298)3.88792936
9Abnormality of DNA repair (HP:0003254)3.69743281
10Enlarged epiphyses (HP:0010580)3.62400458
11Pili torti (HP:0003777)3.61588126
12Morphological abnormality of the middle ear (HP:0008609)3.47710774
13Duplicated collecting system (HP:0000081)3.41998543
14Bilateral sensorineural hearing impairment (HP:0008619)3.37963953
15Tibial bowing (HP:0002982)3.29117164
16Abnormality of the nasal septum (HP:0000419)3.21804649
17Abnormality of the renal collecting system (HP:0004742)3.19785008
18Ectopic kidney (HP:0000086)3.15729617
19Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.14130862
20Thin bony cortex (HP:0002753)3.04851213
21Abnormal hair laboratory examination (HP:0003328)3.03686245
22Neonatal short-limb short stature (HP:0008921)3.01784986
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99472798
24Urethral obstruction (HP:0000796)2.94439963
25Spinal muscular atrophy (HP:0007269)2.91182432
26Abnormality of the carotid arteries (HP:0005344)2.89587664
27Cystic liver disease (HP:0006706)2.87612208
28Hyperkalemia (HP:0002153)2.70518364
29Keratoconus (HP:0000563)2.58836792
30Increased corneal curvature (HP:0100692)2.58836792
31Natal tooth (HP:0000695)2.53585655
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.53326800
33Hypoplastic iliac wings (HP:0002866)2.47867354
34Cerebral aneurysm (HP:0004944)2.44575204
35Broad metatarsal (HP:0001783)2.43184175
36Fragile skin (HP:0001030)2.42007313
37Ureteral duplication (HP:0000073)2.41684407
38Abnormal trabecular bone morphology (HP:0100671)2.38565174
39Tubular atrophy (HP:0000092)2.36903481
40Hemorrhage of the eye (HP:0011885)2.34920773
41Duplication of thumb phalanx (HP:0009942)2.33911073
42Abnormal number of incisors (HP:0011064)2.33681565
43Self-mutilation (HP:0000742)2.31283253
44Chromsome breakage (HP:0040012)2.28567350
45Broad face (HP:0000283)2.25022085
46Abnormality of pyrimidine metabolism (HP:0004353)2.21266045
47Pendular nystagmus (HP:0012043)2.19538466
48Abnormality of chloride homeostasis (HP:0011422)2.19313233
49Broad ribs (HP:0000885)2.18747915
50Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17866648
51Short 4th metacarpal (HP:0010044)2.17866648
52Hypophosphatemic rickets (HP:0004912)2.16439863
53Milia (HP:0001056)2.14809206
54Congenital, generalized hypertrichosis (HP:0004540)2.13496917
55Periorbital edema (HP:0100539)2.12506407
56Abnormality of the costochondral junction (HP:0000919)2.11870940
57Abnormality of the ischium (HP:0003174)2.09418693
58Bony spicule pigmentary retinopathy (HP:0007737)2.06878197
59True hermaphroditism (HP:0010459)2.06805511
60Abnormality of the distal phalanx of the thumb (HP:0009617)2.03744528
61Abnormality of the odontoid process (HP:0003310)2.03092831
62Facial edema (HP:0000282)2.02885139
63Abnormality of the sella turcica (HP:0002679)2.01461777
64Aortic regurgitation (HP:0001659)2.00287184
65Abnormality of the aortic arch (HP:0012303)1.99710894
66Severe visual impairment (HP:0001141)1.99255904
67Abnormality of the ileum (HP:0001549)1.97903312
68Single umbilical artery (HP:0001195)1.97357441
69Abnormality of the fetal cardiovascular system (HP:0010948)1.97357441
70Abnormal umbilical cord blood vessels (HP:0011403)1.97357441
71Delayed epiphyseal ossification (HP:0002663)1.97324297
72Depressed nasal tip (HP:0000437)1.94991676
73Abnormality of the preputium (HP:0100587)1.93450126
74Meckel diverticulum (HP:0002245)1.92759315
75Distal upper limb amyotrophy (HP:0007149)1.91173126
76Upper limb amyotrophy (HP:0009129)1.91173126
77Hypoplastic ischia (HP:0003175)1.90618084
78Distal lower limb amyotrophy (HP:0008944)1.89838639
79Difficulty climbing stairs (HP:0003551)1.89454826
80Wide anterior fontanel (HP:0000260)1.88605681
81Malnutrition (HP:0004395)1.87670099
82Stage 5 chronic kidney disease (HP:0003774)1.86992854
83Tented upper lip vermilion (HP:0010804)1.86596814
84Nuclear cataract (HP:0100018)1.85774528
85Abnormality of the dental pulp (HP:0006479)1.85109093
86Bronchomalacia (HP:0002780)1.84413946
87Abnormality of the renal cortex (HP:0011035)1.80918301
88Abnormality of the distal phalanges of the toes (HP:0010182)1.80807285
89Short thumb (HP:0009778)1.78911722
90Abnormality of the 4th metacarpal (HP:0010012)1.77406482
91Polar cataract (HP:0010696)1.75640283
92Flat acetabular roof (HP:0003180)1.74138221
93Laryngomalacia (HP:0001601)1.72406282
94Bilateral microphthalmos (HP:0007633)1.71562364
95Tubulointerstitial nephritis (HP:0001970)1.70686207
96Mildly elevated creatine phosphokinase (HP:0008180)1.70050967
97Abnormality of the fibula (HP:0002991)1.69908536
98Absent thumb (HP:0009777)1.69622206
99Anal stenosis (HP:0002025)1.69596381
100Abnormality of incisor morphology (HP:0011063)1.68733878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.11285218
2MST1R6.64073631
3NME14.95864120
4PNCK3.52536355
5TSSK63.12884956
6MAPK153.03355341
7CDK122.83138970
8MET2.81613714
9TIE12.71395558
10INSRR2.45256043
11WNK12.35613804
12CASK1.93186024
13IRAK11.77053753
14LMTK21.65148284
15STK391.62708571
16WEE11.61230728
17SIK21.45481774
18MUSK1.30930103
19ICK1.29764067
20DDR21.29356076
21MAPKAPK31.26662237
22GRK11.15573661
23VRK11.12374243
24NEK21.09663998
25CDK91.03202927
26BMPR1B0.99644583
27ACVR1B0.98856983
28BLK0.98671124
29MAP2K60.97429848
30MAPKAPK50.93801419
31OXSR10.84664545
32CAMK1D0.82852482
33TYRO30.81717505
34ERBB20.80459223
35PRKCH0.78234992
36MAP3K60.72614492
37FGFR20.68640923
38FRK0.67979551
39TRIB30.67604055
40CAMK1G0.67417847
41MELK0.65436912
42MAP2K20.63796856
43PDGFRB0.63506204
44TRPM70.60817265
45TGFBR10.58131914
46RET0.56220634
47MTOR0.54604267
48MAP2K10.53593724
49MKNK20.52232556
50TNIK0.49700329
51NTRK30.49402118
52PTK2B0.48444112
53MAPK110.45648248
54PRKAA10.45235829
55RPS6KA50.43391573
56PAK20.43257087
57NTRK20.43136389
58CDK30.41351198
59GRK70.41040650
60DAPK20.40878668
61ZAK0.39509473
62MAP3K130.38020816
63MAP4K20.36831404
64ERN10.36642401
65CDK80.36115613
66CHUK0.34971842
67FGFR40.34872646
68PIK3CG0.34798139
69PASK0.34029570
70ADRBK20.33865944
71RPS6KA60.33170460
72CAMK2B0.31135108
73EPHA20.29467921
74MAPK10.28629348
75MKNK10.28363517
76PAK30.28210953
77TLK10.27193282
78SGK10.25555871
79IGF1R0.24934755
80PTK20.23488646
81ADRBK10.23131428
82PRKD30.22544983
83ITK0.21988185
84CAMK40.21305392
85CDC42BPA0.20838111
86PIK3CA0.20071896
87TAOK30.19903413
88ROCK10.18678314
89MAPK30.18660124
90PRKAA20.18079627
91KIT0.17876989
92MAP3K90.17698559
93ATR0.17692051
94PRKCG0.15542032
95PHKG20.14408353
96PHKG10.14408353
97PDGFRA0.14385664
98NLK0.13400592
99GSK3B0.12762424
100PKN20.12064532

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004503.58423279
2Progesterone-mediated oocyte maturation_Homo sapiens_hsa049143.31107792
3Taste transduction_Homo sapiens_hsa047423.10111416
4Salivary secretion_Homo sapiens_hsa049702.96555292
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.93804087
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.62310769
7ABC transporters_Homo sapiens_hsa020102.31376883
8Systemic lupus erythematosus_Homo sapiens_hsa053222.23013754
9Oocyte meiosis_Homo sapiens_hsa041142.08347713
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.06729307
11Linoleic acid metabolism_Homo sapiens_hsa005911.85338208
12Ovarian steroidogenesis_Homo sapiens_hsa049131.82950734
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69596964
14Fanconi anemia pathway_Homo sapiens_hsa034601.68662195
15ECM-receptor interaction_Homo sapiens_hsa045121.66397257
16Protein digestion and absorption_Homo sapiens_hsa049741.64163952
17Circadian entrainment_Homo sapiens_hsa047131.59368627
18Vibrio cholerae infection_Homo sapiens_hsa051101.51620945
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50600473
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.49986404
21Nicotine addiction_Homo sapiens_hsa050331.49706625
22Olfactory transduction_Homo sapiens_hsa047401.44555844
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.44240740
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41995681
25Alcoholism_Homo sapiens_hsa050341.41227536
26cAMP signaling pathway_Homo sapiens_hsa040241.39632372
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35822052
28Insulin secretion_Homo sapiens_hsa049111.34316238
29Thyroid hormone synthesis_Homo sapiens_hsa049181.31135218
30Basal cell carcinoma_Homo sapiens_hsa052171.29895512
31Calcium signaling pathway_Homo sapiens_hsa040201.26686720
32Glutamatergic synapse_Homo sapiens_hsa047241.16782288
33Lysine degradation_Homo sapiens_hsa003101.15349810
34Gastric acid secretion_Homo sapiens_hsa049711.14023016
35Notch signaling pathway_Homo sapiens_hsa043301.13223560
36Renin secretion_Homo sapiens_hsa049241.11159505
37Caffeine metabolism_Homo sapiens_hsa002321.06453900
38Dorso-ventral axis formation_Homo sapiens_hsa043201.05360714
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04826181
40Serotonergic synapse_Homo sapiens_hsa047261.02899623
41Chemical carcinogenesis_Homo sapiens_hsa052041.00144298
42Ether lipid metabolism_Homo sapiens_hsa005650.99714903
43Estrogen signaling pathway_Homo sapiens_hsa049150.97144441
44Amoebiasis_Homo sapiens_hsa051460.96397200
45Dilated cardiomyopathy_Homo sapiens_hsa054140.92081163
46Morphine addiction_Homo sapiens_hsa050320.90426507
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89851433
48Bile secretion_Homo sapiens_hsa049760.89680782
49GnRH signaling pathway_Homo sapiens_hsa049120.86622623
50Nitrogen metabolism_Homo sapiens_hsa009100.85699683
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85387322
52Cocaine addiction_Homo sapiens_hsa050300.83429701
53Vitamin B6 metabolism_Homo sapiens_hsa007500.82777424
54Homologous recombination_Homo sapiens_hsa034400.78916709
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76688984
56Pancreatic secretion_Homo sapiens_hsa049720.73764575
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71979284
58Cholinergic synapse_Homo sapiens_hsa047250.71300936
59Fructose and mannose metabolism_Homo sapiens_hsa000510.65990171
60GABAergic synapse_Homo sapiens_hsa047270.64727604
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64562466
62Gap junction_Homo sapiens_hsa045400.63802833
63MAPK signaling pathway_Homo sapiens_hsa040100.63428755
64Long-term depression_Homo sapiens_hsa047300.60827800
65TGF-beta signaling pathway_Homo sapiens_hsa043500.59115093
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58969709
67Mineral absorption_Homo sapiens_hsa049780.57708316
68Axon guidance_Homo sapiens_hsa043600.55923330
69Primary immunodeficiency_Homo sapiens_hsa053400.55178630
70Choline metabolism in cancer_Homo sapiens_hsa052310.53371701
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53214509
72Platelet activation_Homo sapiens_hsa046110.52644371
73Hedgehog signaling pathway_Homo sapiens_hsa043400.51965449
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.51965424
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51237608
76Melanogenesis_Homo sapiens_hsa049160.50773328
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49198565
78Focal adhesion_Homo sapiens_hsa045100.45332404
79Arachidonic acid metabolism_Homo sapiens_hsa005900.42842961
80Sulfur metabolism_Homo sapiens_hsa009200.42745261
81Fatty acid biosynthesis_Homo sapiens_hsa000610.42261266
82Oxytocin signaling pathway_Homo sapiens_hsa049210.41769348
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40357118
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.40025582
85Viral carcinogenesis_Homo sapiens_hsa052030.37111777
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36469044
87African trypanosomiasis_Homo sapiens_hsa051430.35324936
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35249586
89Rap1 signaling pathway_Homo sapiens_hsa040150.35083774
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34844435
91MicroRNAs in cancer_Homo sapiens_hsa052060.34820970
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34282371
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34250292
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33458729
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32747599
96Tight junction_Homo sapiens_hsa045300.32520199
97Starch and sucrose metabolism_Homo sapiens_hsa005000.32392797
98Amphetamine addiction_Homo sapiens_hsa050310.31680486
99Pathways in cancer_Homo sapiens_hsa052000.30969718
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.28704946

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