TCF20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.66013897
2nuclear pore organization (GO:0006999)5.04172840
3regulation of RNA export from nucleus (GO:0046831)4.79587773
4mitotic sister chromatid cohesion (GO:0007064)4.40109830
5pre-miRNA processing (GO:0031054)4.33823030
6pore complex assembly (GO:0046931)4.03618775
7dosage compensation (GO:0007549)4.00880671
8regulation of nucleobase-containing compound transport (GO:0032239)3.91309177
9embryonic process involved in female pregnancy (GO:0060136)3.86593073
10negative regulation of histone methylation (GO:0031061)3.85265195
11cytoplasmic mRNA processing body assembly (GO:0033962)3.70576548
12positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.68297897
13positive regulation of mitotic sister chromatid separation (GO:1901970)3.68297897
14positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.68297897
15regulation of protein polyubiquitination (GO:1902914)3.63716138
16positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.63564065
17regulation of translational fidelity (GO:0006450)3.57023278
18regulation of histone H3-K9 methylation (GO:0051570)3.51811730
19regulation of sister chromatid cohesion (GO:0007063)3.46328945
20RNA stabilization (GO:0043489)3.43770344
21mRNA stabilization (GO:0048255)3.43770344
22sister chromatid segregation (GO:0000819)3.40918654
23establishment of apical/basal cell polarity (GO:0035089)3.34667795
24regulation of histone H3-K27 methylation (GO:0061085)3.28188428
25monoubiquitinated protein deubiquitination (GO:0035520)3.23657033
26cytoskeletal anchoring at plasma membrane (GO:0007016)3.18038564
27hemidesmosome assembly (GO:0031581)3.16303155
28histone H3-K4 trimethylation (GO:0080182)3.16270473
29chromatin assembly (GO:0031497)3.10066878
30mitotic chromosome condensation (GO:0007076)3.08608363
31adherens junction assembly (GO:0034333)3.07991785
32histone H3-K9 demethylation (GO:0033169)3.07801086
33histone lysine demethylation (GO:0070076)3.07464608
34peptidyl-lysine dimethylation (GO:0018027)3.07433403
35negative regulation of DNA repair (GO:0045738)3.06749290
36NLS-bearing protein import into nucleus (GO:0006607)3.04403674
37activation of Rac GTPase activity (GO:0032863)3.00113863
38spliceosomal tri-snRNP complex assembly (GO:0000244)3.00098873
39establishment or maintenance of monopolar cell polarity (GO:0061339)3.00086270
40establishment of monopolar cell polarity (GO:0061162)3.00086270
41focal adhesion assembly (GO:0048041)2.99814798
42cell-substrate adherens junction assembly (GO:0007045)2.99814798
43mitotic nuclear envelope disassembly (GO:0007077)2.99658140
44membrane disassembly (GO:0030397)2.96281119
45nuclear envelope disassembly (GO:0051081)2.96281119
46histone H4-K12 acetylation (GO:0043983)2.95008772
47replication fork processing (GO:0031297)2.94981474
48cell-substrate junction assembly (GO:0007044)2.92119778
49protein localization to endosome (GO:0036010)2.90923954
50histone demethylation (GO:0016577)2.90211344
51embryonic placenta development (GO:0001892)2.86732104
52regulation of integrin activation (GO:0033623)2.85955507
53gene silencing by RNA (GO:0031047)2.85489253
54histone mRNA catabolic process (GO:0071044)2.85354678
55negative regulation of erythrocyte differentiation (GO:0045647)2.84192389
56DNA duplex unwinding (GO:0032508)2.84094541
57regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.84064547
58response to UV-C (GO:0010225)2.83931987
59DNA geometric change (GO:0032392)2.82666462
60mitotic G1 DNA damage checkpoint (GO:0031571)2.82578834
61mitotic sister chromatid segregation (GO:0000070)2.81923093
62regulation of ARF protein signal transduction (GO:0032012)2.81609960
63heterochromatin organization (GO:0070828)2.81208206
64regulation of chromatin binding (GO:0035561)2.80890617
65histone H2A monoubiquitination (GO:0035518)2.78855302
66glucocorticoid receptor signaling pathway (GO:0042921)2.78026742
67response to epidermal growth factor (GO:0070849)2.77684917
68positive regulation of chromosome segregation (GO:0051984)2.76880237
69positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.76666731
70regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.75792327
71paraxial mesoderm development (GO:0048339)2.74431140
72trophectodermal cell differentiation (GO:0001829)2.72276856
73cellular response to epidermal growth factor stimulus (GO:0071364)2.71987321
74regulation of hippo signaling (GO:0035330)2.71395374
753-UTR-mediated mRNA stabilization (GO:0070935)2.71050084
76protein export from nucleus (GO:0006611)2.70500841
77regulation of DNA endoreduplication (GO:0032875)2.69859505
78stress granule assembly (GO:0034063)2.68479883
79protein demethylation (GO:0006482)2.66622266
80protein dealkylation (GO:0008214)2.66622266
81nucleus organization (GO:0006997)2.65714651
82response to laminar fluid shear stress (GO:0034616)2.64353045
83histone H3-K36 demethylation (GO:0070544)2.64339545
84regulation of histone methylation (GO:0031060)2.63684893
85chromosome condensation (GO:0030261)2.63312404
86embryonic camera-type eye morphogenesis (GO:0048596)2.62107744
87hypotonic response (GO:0006971)2.61013144
88hippo signaling (GO:0035329)2.60015900
89protein-DNA complex disassembly (GO:0032986)2.59502440
90nucleosome disassembly (GO:0006337)2.59502440
91regulation of DNA damage checkpoint (GO:2000001)2.58498786
92DNA topological change (GO:0006265)2.57827248
93establishment of nucleus localization (GO:0040023)2.57779109
94negative regulation of histone modification (GO:0031057)2.57584268
95regulation of NFAT protein import into nucleus (GO:0051532)2.56604772
96regulation of gene silencing by RNA (GO:0060966)2.55738439
97regulation of posttranscriptional gene silencing (GO:0060147)2.55738439
98regulation of gene silencing by miRNA (GO:0060964)2.55738439
99DNA unwinding involved in DNA replication (GO:0006268)2.54792117
100peptidyl-threonine phosphorylation (GO:0018107)2.54558185
101regulation of clathrin-mediated endocytosis (GO:2000369)2.54136233
102gene silencing (GO:0016458)2.52943590
103insulin-like growth factor receptor signaling pathway (GO:0048009)2.52440222
104embryonic eye morphogenesis (GO:0048048)2.52144957
105G1 DNA damage checkpoint (GO:0044783)2.52039456
106histone H3-K4 methylation (GO:0051568)2.50317900
107maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.49861024
108phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.49277437
109histone H4-K16 acetylation (GO:0043984)2.48754897
110epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47888861
111positive regulation of dendritic spine morphogenesis (GO:0061003)2.47546353
112nuclear envelope organization (GO:0006998)2.47406177
113histone H3-K9 methylation (GO:0051567)2.46965973
114histone H4-K8 acetylation (GO:0043982)2.46610244
115histone H4-K5 acetylation (GO:0043981)2.46610244
116corticosteroid receptor signaling pathway (GO:0031958)2.46510954
117peptidyl-threonine modification (GO:0018210)2.45729326
118regulation of centriole replication (GO:0046599)2.45447885
119cellular protein complex localization (GO:0034629)2.43974345
120regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.43406937
121positive regulation by host of viral transcription (GO:0043923)2.42341697
122protein localization to kinetochore (GO:0034501)2.42292011
123planar cell polarity pathway involved in neural tube closure (GO:0090179)2.41984730
124negative regulation of chromatin modification (GO:1903309)2.40846958
125peptidyl-lysine trimethylation (GO:0018023)2.40658118
126positive regulation of gene expression, epigenetic (GO:0045815)2.40627535
127histone lysine methylation (GO:0034968)2.40178120
128negative regulation of myotube differentiation (GO:0010832)2.40168246
129regulation of centrosome duplication (GO:0010824)2.39498092
130chromatin silencing (GO:0006342)2.38982077
131somatic hypermutation of immunoglobulin genes (GO:0016446)2.38910675
132somatic diversification of immune receptors via somatic mutation (GO:0002566)2.38910675
133desmosome organization (GO:0002934)2.38456109
134regulation of histone H3-K4 methylation (GO:0051569)2.38146452
135intracellular estrogen receptor signaling pathway (GO:0030520)2.37491723
136regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.37395038
137nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.36918829
138DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.36597882
139sister chromatid cohesion (GO:0007062)2.35846377
140DNA packaging (GO:0006323)2.35754498
141regulation of glucose import in response to insulin stimulus (GO:2001273)2.35096570
142regulation of mRNA stability (GO:0043488)2.34937181
143positive regulation of Cdc42 GTPase activity (GO:0043089)2.34585489
144mRNA cleavage (GO:0006379)2.34117959
145determination of adult lifespan (GO:0008340)2.33553613
146mitotic G1/S transition checkpoint (GO:0044819)2.33206737
147regulation of RNA stability (GO:0043487)2.32069112
148protein localization to microtubule (GO:0035372)2.31115232
149protein complex localization (GO:0031503)2.30992213
150DNA conformation change (GO:0071103)2.24377759
151positive regulation of cellular response to insulin stimulus (GO:1900078)2.22107566
152apoptotic process involved in morphogenesis (GO:0060561)2.21172218
153positive regulation of keratinocyte differentiation (GO:0045618)2.15885473
154oocyte development (GO:0048599)2.14293465
155negative regulation of fatty acid transport (GO:2000192)2.13606110
156positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.11248545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.41371297
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.92677939
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.53483187
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.97525282
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.81854619
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.70157065
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.29349465
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.22169685
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.75691025
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.51891851
11SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.48957449
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.47876753
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40073887
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.38261079
15MYC_22102868_ChIP-Seq_BL_Human2.31868836
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28818988
17TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.10943631
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10172444
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.03399462
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93050724
21ZFP281_27345836_Chip-Seq_ESCs_Mouse1.92425079
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.91607622
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.87910737
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85585058
25DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.84304774
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83018903
27PKCTHETA_26484144_Chip-Seq_BREAST_Human1.82089800
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79441967
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.78369922
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77796494
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.75581024
32FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.74058765
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73306876
34KDM2B_26808549_Chip-Seq_DND41_Human1.67666344
35TCF7_22412390_ChIP-Seq_EML_Mouse1.65064457
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.64328592
37RACK7_27058665_Chip-Seq_MCF-7_Human1.59772699
38MAF_26560356_Chip-Seq_TH1_Human1.55379175
39NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.52827176
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52098353
41* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.48743033
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48697954
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.45765371
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42426102
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41172599
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41011326
47CLOCK_20551151_ChIP-Seq_293T_Human1.40920860
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40462133
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38515222
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36077713
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35305355
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34785661
53NANOG_21062744_ChIP-ChIP_HESCs_Human1.33994363
54LXR_22292898_ChIP-Seq_THP-1_Human1.32695762
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31370828
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29957102
57VDR_24763502_ChIP-Seq_THP-1_Human1.29196857
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28421902
59KDM2B_26808549_Chip-Seq_K562_Human1.28012471
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.27841563
61SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.25807196
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25438844
63POU5F1_16518401_ChIP-PET_MESCs_Mouse1.25118833
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24737653
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24693602
66VDR_21846776_ChIP-Seq_THP-1_Human1.23896608
67POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.22680874
68SCL_19346495_ChIP-Seq_HPC-7_Human1.20479043
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19022059
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18612567
71SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18023643
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17993389
73TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17452840
74NCOR1_26117541_ChIP-Seq_K562_Human1.16762176
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16504828
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16211597
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16211597
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16105485
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15381526
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15288945
81TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15223290
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14844180
83TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14425600
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13840348
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13477848
86MYB_26560356_Chip-Seq_TH1_Human1.12795958
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.12471585
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11261708
89ATF3_27146783_Chip-Seq_COLON_Human1.10829666
90* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10823295
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10457146
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10431046
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10233300
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10087280
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.09882994
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09728265
97RARB_27405468_Chip-Seq_BRAIN_Mouse1.09554848
98* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08698622
99TP53_16413492_ChIP-PET_HCT116_Human1.08678980
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07584048
101CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05987561
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04705173
103MAF_26560356_Chip-Seq_TH2_Human1.04658748
104CHD1_26751641_Chip-Seq_LNCaP_Human1.02347261
105ISL1_27105846_Chip-Seq_CPCs_Mouse1.01717883
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01562186
107BRD4_25478319_ChIP-Seq_HGPS_Human1.00105204
108TCF4_18268006_ChIP-ChIP_LS174T_Human0.99999798
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99713980
110* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99484822
111RUNX_20019798_ChIP-Seq_JUKART_Human0.99000206
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98947411
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98838412
114* GATA1_19941827_ChIP-Seq_MEL_Mouse0.98782804
115PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98505841
116SPI1_23127762_ChIP-Seq_K562_Human0.98302804
117GATA6_25053715_ChIP-Seq_YYC3_Human0.97845053
118GATA1_19941826_ChIP-Seq_K562_Human0.96718291
119* SMC4_20622854_ChIP-Seq_HELA_Human0.96474404
120STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95527793
121FOXA2_19822575_ChIP-Seq_HepG2_Human0.93898237
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93180899
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91844419
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91558229
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91085113
126* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90564379
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90192401
128AR_21909140_ChIP-Seq_LNCAP_Human0.89250117
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85787673
130UTX_26944678_Chip-Seq_JUKART_Human0.85329938
131NANOG_16518401_ChIP-PET_MESCs_Mouse0.84247197
132FOXO3_23340844_ChIP-Seq_DLD1_Human0.84068398
133CREB1_26743006_Chip-Seq_LNCaP_Human0.82429288
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82356432
135* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.82286772
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80696870
137RUNX1_27514584_Chip-Seq_MCF-7_Human0.80035227
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79639382
139NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78986954
140RING1B_27294783_Chip-Seq_NPCs_Mouse0.78686279
141ZNF263_19887448_ChIP-Seq_K562_Human0.78492637
142KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78466006
143KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78466006
144KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78466006
145* AR_19668381_ChIP-Seq_PC3_Human0.78373811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.73770354
2MP0005076_abnormal_cell_differentiation3.38899705
3MP0008057_abnormal_DNA_replication3.28982538
4MP0010352_gastrointestinal_tract_polyps3.06307268
5MP0010307_abnormal_tumor_latency2.65414836
6MP0003705_abnormal_hypodermis_morpholog2.65052832
7MP0003890_abnormal_embryonic-extraembry2.63359256
8MP0008877_abnormal_DNA_methylation2.58179638
9MP0005409_darkened_coat_color2.43507337
10MP0010234_abnormal_vibrissa_follicle2.32789254
11MP0005451_abnormal_body_composition2.24319785
12MP0010094_abnormal_chromosome_stability2.20740025
13MP0004233_abnormal_muscle_weight2.18335165
14MP0002796_impaired_skin_barrier2.14749845
15MP0002009_preneoplasia2.11084099
16MP0010030_abnormal_orbit_morphology2.06823566
17MP0003763_abnormal_thymus_physiology2.04974036
18MP0002084_abnormal_developmental_patter1.97273687
19MP0003121_genomic_imprinting1.90640249
20MP0003787_abnormal_imprinting1.88421371
21MP0003111_abnormal_nucleus_morphology1.83361141
22MP0002086_abnormal_extraembryonic_tissu1.80679321
23MP0009278_abnormal_bone_marrow1.80290305
24MP0003077_abnormal_cell_cycle1.76373377
25MP0004197_abnormal_fetal_growth/weight/1.73937083
26MP0000350_abnormal_cell_proliferation1.70648222
27MP0002877_abnormal_melanocyte_morpholog1.68322637
28MP0006072_abnormal_retinal_apoptosis1.66934281
29MP0001730_embryonic_growth_arrest1.66737074
30MP0002085_abnormal_embryonic_tissue1.62058410
31MP0005380_embryogenesis_phenotype1.59404254
32MP0001672_abnormal_embryogenesis/_devel1.59404254
33MP0001697_abnormal_embryo_size1.58260526
34MP0001293_anophthalmia1.55100590
35MP0001348_abnormal_lacrimal_gland1.54916842
36MP0003283_abnormal_digestive_organ1.53308946
37MP0000537_abnormal_urethra_morphology1.51765196
38MP0002653_abnormal_ependyma_morphology1.51079271
39MP0008260_abnormal_autophagy1.49948766
40MP0003984_embryonic_growth_retardation1.48267096
41MP0002088_abnormal_embryonic_growth/wei1.46977150
42MP0004858_abnormal_nervous_system1.45251572
43MP0004947_skin_inflammation1.45133509
44MP0003045_fibrosis1.44194914
45MP0003119_abnormal_digestive_system1.41400901
46MP0003935_abnormal_craniofacial_develop1.36648855
47MP0009672_abnormal_birth_weight1.35155211
48MP0005171_absent_coat_pigmentation1.35150935
49MP0003123_paternal_imprinting1.34743785
50MP0000579_abnormal_nail_morphology1.33993482
51MP0005501_abnormal_skin_physiology1.33434986
52MP0004264_abnormal_extraembryonic_tissu1.31777955
53MP0005623_abnormal_meninges_morphology1.30682950
54MP0009703_decreased_birth_body1.30489672
55MP0002166_altered_tumor_susceptibility1.30024581
56MP0004381_abnormal_hair_follicle1.29878032
57MP0003303_peritoneal_inflammation1.29188447
58MP0004957_abnormal_blastocyst_morpholog1.29153310
59MP0003091_abnormal_cell_migration1.28957792
60MP0000733_abnormal_muscle_development1.27914029
61MP0000566_synostosis1.26875270
62MP0001216_abnormal_epidermal_layer1.24426673
63MP0002060_abnormal_skin_morphology1.23488802
64MP0005253_abnormal_eye_physiology1.22492349
65MP0000703_abnormal_thymus_morphology1.21889595
66MP0002089_abnormal_postnatal_growth/wei1.21881486
67MP0009053_abnormal_anal_canal1.21520370
68MP0008058_abnormal_DNA_repair1.19964584
69MP0003941_abnormal_skin_development1.18905608
70MP0005666_abnormal_adipose_tissue1.18286122
71MP0001849_ear_inflammation1.17854833
72MP0004808_abnormal_hematopoietic_stem1.17748719
73MP0005187_abnormal_penis_morphology1.16242558
74MP0005248_abnormal_Harderian_gland1.16154099
75MP0003115_abnormal_respiratory_system1.15022822
76MP0000377_abnormal_hair_follicle1.14687356
77MP0005391_vision/eye_phenotype1.13960616
78MP0003566_abnormal_cell_adhesion1.12267721
79MP0004859_abnormal_synaptic_plasticity1.11311587
80MP0002697_abnormal_eye_size1.10825827
81MP0000371_diluted_coat_color1.10589751
82MP0002080_prenatal_lethality1.10131635
83MP0003861_abnormal_nervous_system1.09483611
84MP0005310_abnormal_salivary_gland1.08817440
85MP0008007_abnormal_cellular_replicative1.08742487
86MP0000432_abnormal_head_morphology1.08577634
87MP0000428_abnormal_craniofacial_morphol1.08373046
88MP0004185_abnormal_adipocyte_glucose1.07875698
89MP0002925_abnormal_cardiovascular_devel1.07216249
90MP0002098_abnormal_vibrissa_morphology1.06018100
91MP0002006_tumorigenesis1.05511644
92MP0002092_abnormal_eye_morphology1.04596670
93MP0003567_abnormal_fetal_cardiomyocyte1.04499064
94MP0005397_hematopoietic_system_phenotyp1.04312542
95MP0001545_abnormal_hematopoietic_system1.04312542
96MP0003385_abnormal_body_wall1.04169316
97MP0003300_gastrointestinal_ulcer1.04031080
98MP0003937_abnormal_limbs/digits/tail_de1.03937607
99MP0005551_abnormal_eye_electrophysiolog1.03097307
100MP0008961_abnormal_basal_metabolism1.01099604
101MP0001915_intracranial_hemorrhage1.00727448
102MP0003755_abnormal_palate_morphology0.99447601
103MP0001324_abnormal_eye_pigmentation0.99410517
104MP0001299_abnormal_eye_distance/0.99313351
105MP0000490_abnormal_crypts_of0.96629295
106MP0005367_renal/urinary_system_phenotyp0.93899222
107MP0000516_abnormal_urinary_system0.93899222
108MP0001873_stomach_inflammation0.93874717
109MP0003693_abnormal_embryo_hatching0.92402559
110MP0002398_abnormal_bone_marrow0.91112140
111MP0003122_maternal_imprinting0.90665359
112MP0005375_adipose_tissue_phenotype0.89938631
113MP0005384_cellular_phenotype0.87925312
114MP0000678_abnormal_parathyroid_gland0.86641422
115MP0003453_abnormal_keratinocyte_physiol0.84887878
116MP0010630_abnormal_cardiac_muscle0.84594417
117MP0005023_abnormal_wound_healing0.84031552
118MP0001851_eye_inflammation0.83839443
119MP0000858_altered_metastatic_potential0.83006126
120MP0000383_abnormal_hair_follicle0.82819570
121MP0002116_abnormal_craniofacial_bone0.80592131
122MP0002075_abnormal_coat/hair_pigmentati0.80536691
123MP0000627_abnormal_mammary_gland0.80318076
124MP0009931_abnormal_skin_appearance0.80216088
125MP0008770_decreased_survivor_rate0.79727209
126MP0002396_abnormal_hematopoietic_system0.79139952
127MP0002282_abnormal_trachea_morphology0.78996256
128MP0008995_early_reproductive_senescence0.78107828
129MP0003436_decreased_susceptibility_to0.77784776
130MP0000762_abnormal_tongue_morphology0.77733113
131MP0000313_abnormal_cell_death0.75794689
132MP0001784_abnormal_fluid_regulation0.74000311
133MP0002111_abnormal_tail_morphology0.73983355
134MP0000477_abnormal_intestine_morphology0.73135722
135MP0001286_abnormal_eye_development0.72312244
136MP0010678_abnormal_skin_adnexa0.71662579
137MP0000003_abnormal_adipose_tissue0.70553673
138MP0003943_abnormal_hepatobiliary_system0.69870656
139MP0005621_abnormal_cell_physiology0.69343962
140MP0002722_abnormal_immune_system0.67154695
141MP0005257_abnormal_intraocular_pressure0.63858432

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.68231926
2Astrocytoma (HP:0009592)3.07902299
3Abnormality of the astrocytes (HP:0100707)3.07902299
4Abnormality of the fingertips (HP:0001211)3.02057002
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.97437752
6Short 4th metacarpal (HP:0010044)2.97437752
7Heterotopia (HP:0002282)2.82717502
8Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.82564082
9Macroorchidism (HP:0000053)2.77498678
10Abnormality of the distal phalanx of the thumb (HP:0009617)2.77006681
11Broad face (HP:0000283)2.74853450
12Flat acetabular roof (HP:0003180)2.70649568
13Facial hemangioma (HP:0000329)2.68940991
14Obstructive sleep apnea (HP:0002870)2.67043907
15Cerebral aneurysm (HP:0004944)2.64516967
16Bony spicule pigmentary retinopathy (HP:0007737)2.52943589
17Abnormality of the labia minora (HP:0012880)2.51166049
18Urethral obstruction (HP:0000796)2.43136896
19Annular pancreas (HP:0001734)2.41830125
20Glioma (HP:0009733)2.38347418
21Vertebral arch anomaly (HP:0008438)2.36304335
22Ependymoma (HP:0002888)2.35845410
23Asymmetry of the thorax (HP:0001555)2.35697241
24Ulnar bowing (HP:0003031)2.35115496
25Milia (HP:0001056)2.34180867
26Deep palmar crease (HP:0006191)2.33861813
27Broad thumb (HP:0011304)2.33542307
28Neoplasm of the oral cavity (HP:0100649)2.33134087
29Aqueductal stenosis (HP:0002410)2.29674747
30Long eyelashes (HP:0000527)2.27955044
31Narrow palate (HP:0000189)2.26344762
32Prominent nose (HP:0000448)2.25230621
33Abnormality of the lower motor neuron (HP:0002366)2.20112720
34Papillary thyroid carcinoma (HP:0002895)2.19427646
35Dislocated radial head (HP:0003083)2.18896781
36Absent frontal sinuses (HP:0002688)2.17054022
37Short humerus (HP:0005792)2.10357142
38Neonatal hypoglycemia (HP:0001998)2.08604691
39Abnormality of the nasal septum (HP:0000419)2.08556633
40Germ cell neoplasia (HP:0100728)2.08318745
41Syringomyelia (HP:0003396)2.07667184
42Spinal cord lesions (HP:0100561)2.07667184
43Long palpebral fissure (HP:0000637)2.07429671
44Abnormality of the 4th metacarpal (HP:0010012)2.06916610
45Rib fusion (HP:0000902)2.06741404
46Truncal obesity (HP:0001956)2.05191783
47Subacute progressive viral hepatitis (HP:0006572)2.03584940
48Abnormality of the salivary glands (HP:0010286)2.02817582
49Sandal gap (HP:0001852)2.01753014
50Abnormality of the radial head (HP:0003995)1.99387109
51Deep philtrum (HP:0002002)1.99306474
52Advanced eruption of teeth (HP:0006288)1.98708784
53Obsessive-compulsive behavior (HP:0000722)1.97126419
54Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.96787954
55Shallow orbits (HP:0000586)1.95055439
56Trigonocephaly (HP:0000243)1.93738481
57Malignant gastrointestinal tract tumors (HP:0006749)1.92154623
58Gastrointestinal carcinoma (HP:0002672)1.92154623
59High anterior hairline (HP:0009890)1.90587153
60Hypochromic microcytic anemia (HP:0004840)1.90215997
61Ankyloglossia (HP:0010296)1.90058017
62Viral hepatitis (HP:0006562)1.89470641
63Cubitus valgus (HP:0002967)1.88923004
64Chorioretinal atrophy (HP:0000533)1.87863639
65Basal cell carcinoma (HP:0002671)1.86988290
66Congenital stationary night blindness (HP:0007642)1.86786007
67Broad phalanges of the hand (HP:0009768)1.86748795
68Transitional cell carcinoma of the bladder (HP:0006740)1.86342902
69Right ventricular cardiomyopathy (HP:0011663)1.85327640
70Termporal pattern (HP:0011008)1.84042575
71Insidious onset (HP:0003587)1.84042575
72Increased number of teeth (HP:0011069)1.83441911
73Colitis (HP:0002583)1.82804691
74Renal cell carcinoma (HP:0005584)1.81834395
75Persistence of primary teeth (HP:0006335)1.81822391
76Eczematoid dermatitis (HP:0000976)1.79779137
77Midline defect of the nose (HP:0004122)1.79384531
78Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78635118
79Deviation of the thumb (HP:0009603)1.78555975
80Hyperacusis (HP:0010780)1.78458166
81Turricephaly (HP:0000262)1.78245611
82Short chin (HP:0000331)1.78043065
83Bladder carcinoma (HP:0002862)1.77949960
84Bladder neoplasm (HP:0009725)1.77949960
85Anal stenosis (HP:0002025)1.77880672
86Disproportionate tall stature (HP:0001519)1.77709699
87Relative macrocephaly (HP:0004482)1.77611323
88Abnormality of oral frenula (HP:0000190)1.77315156
89Aplasia/hypoplasia of the humerus (HP:0006507)1.77259959
90Slow saccadic eye movements (HP:0000514)1.75372801
91Sparse lateral eyebrow (HP:0005338)1.75177460
92Abnormality of the phalanges of the hallux (HP:0010057)1.75163580
93Increased nuchal translucency (HP:0010880)1.75041724
94Selective tooth agenesis (HP:0001592)1.74892697
95Acute myeloid leukemia (HP:0004808)1.74816394
96Medulloblastoma (HP:0002885)1.74533653
97Dysmetric saccades (HP:0000641)1.74247021
98Spinal muscular atrophy (HP:0007269)1.73900087
99Thick nail (HP:0001805)1.73658029
100Uterine leiomyosarcoma (HP:0002891)1.73171726
101Leiomyosarcoma (HP:0100243)1.73171726
102Abnormality of nail color (HP:0100643)1.73077856
103Renovascular hypertension (HP:0100817)1.72152832
104Broad finger (HP:0001500)1.71705586
105Abnormality of the columella (HP:0009929)1.70392469
106Abnormality of the thoracic spine (HP:0100711)1.70042467
107Genu recurvatum (HP:0002816)1.69416093
108Acute lymphatic leukemia (HP:0006721)1.69187842
109Segmental peripheral demyelination/remyelination (HP:0003481)1.68971903
110Ectopic kidney (HP:0000086)1.68578100
111Arnold-Chiari malformation (HP:0002308)1.67557878
112Biliary tract neoplasm (HP:0100574)1.67526117
113Shawl scrotum (HP:0000049)1.65886560
114Proximal placement of thumb (HP:0009623)1.64930323
115Smooth philtrum (HP:0000319)1.64856526
116Natal tooth (HP:0000695)1.64458060
117Overgrowth (HP:0001548)1.64421139
118Curly hair (HP:0002212)1.63831550
119Lip pit (HP:0100267)1.63824446
120Hypoplasia of the maxilla (HP:0000327)1.63758452
121Intestinal fistula (HP:0100819)1.63612746
122Rhabdomyosarcoma (HP:0002859)1.63333604
123Broad phalanx (HP:0006009)1.63082904
124Mitral valve prolapse (HP:0001634)1.62516595
125Osteolytic defects of the hand bones (HP:0009699)1.62182866
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.62182866
127Distal lower limb amyotrophy (HP:0008944)1.61955608
128Low anterior hairline (HP:0000294)1.60631172
129Poikiloderma (HP:0001029)1.59976349
130Oligodontia (HP:0000677)1.59830876
131Precocious puberty (HP:0000826)1.59755089
132Cellulitis (HP:0100658)1.59740220
133Neoplasm of striated muscle (HP:0009728)1.58673078
134Coronal craniosynostosis (HP:0004440)1.58315764
135Cerebral inclusion bodies (HP:0100314)1.58142473
136Bowel incontinence (HP:0002607)1.58028851
137Hypoplastic labia majora (HP:0000059)1.57514979
138Neoplasm of the adrenal cortex (HP:0100641)1.57458799
139Bowel diverticulosis (HP:0005222)1.57081575
140Pointed chin (HP:0000307)1.56727158
141Increased connective tissue (HP:0009025)1.56289349
142Micronodular cirrhosis (HP:0001413)1.56264110
143Short 1st metacarpal (HP:0010034)1.56116239
144Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.56116239
145Sparse scalp hair (HP:0002209)1.56105408
146Hypopigmentation of the fundus (HP:0007894)1.55983044
147Broad palm (HP:0001169)1.55689110
148Skull defect (HP:0001362)1.54595872
149Atrophic scars (HP:0001075)1.54545200
150Abnormality of the humeroradial joint (HP:0100744)1.54212828
151Genetic anticipation (HP:0003743)1.54126133
152Impaired smooth pursuit (HP:0007772)1.52461084
153Colon cancer (HP:0003003)1.52244104
154Cutis marmorata (HP:0000965)1.51523813
155Insomnia (HP:0100785)1.50976532
156Broad long bones (HP:0005622)1.50567188
157Patellar dislocation (HP:0002999)1.50148674
158Abnormal foot bone ossification (HP:0010675)1.49025301
159Abnormality of chromosome segregation (HP:0002916)1.48857788
160Spina bifida occulta (HP:0003298)1.48335427
161Underdeveloped nasal alae (HP:0000430)1.47874999
162Renal duplication (HP:0000075)1.47746350
163Thick eyebrow (HP:0000574)1.47732725
164Alopecia of scalp (HP:0002293)1.46031827
165Fibrous tissue neoplasm (HP:0012316)1.45163061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.12502163
2LATS13.42095805
3ICK3.16376901
4PRPF4B3.01624383
5SMG12.95754202
6DDR22.79042497
7CDC72.65957413
8CAMK1D2.65394454
9PDGFRA2.39576135
10TYRO32.28908068
11FGFR42.04581530
12CAMK1G2.04357710
13MAP3K101.93317793
14BMX1.83550862
15MAP3K91.83250075
16EEF2K1.81843565
17MAP3K61.71278961
18FGFR21.65525375
19MST1R1.64303294
20NEK21.63481746
21LATS21.63257208
22SCYL21.49337341
23MTOR1.49315836
24RIPK11.45373167
25PKN21.42948192
26STK31.34537061
27BRD41.33534809
28PDGFRB1.32502270
29CDK61.32308234
30MAP3K131.29310283
31FRK1.26162785
32STK241.22668746
33CHEK21.21889752
34KSR11.21278881
35NTRK21.14998428
36TRIB31.14942886
37ERN11.14363263
38FGR1.11413582
39KSR21.10328306
40WNK11.09721375
41ATR1.04451610
42FGFR31.02937484
43PRKD21.02818228
44PRKD31.02664443
45DMPK1.01773386
46CHEK11.00823215
47ATM0.97370734
48TTN0.95053147
49SGK30.95038376
50STK380.93341360
51MAP3K40.91474425
52ALK0.91232796
53RPS6KB20.90810195
54MELK0.89695015
55IRAK30.89059255
56MET0.88835511
57FGFR10.88628135
58TLK10.88353599
59AKT30.88129102
60EPHB10.88119493
61DYRK1B0.87880476
62MAP4K10.85967281
63SIK20.85492421
64RIPK40.83094146
65CDK20.83030813
66CDK70.82690757
67CDK90.82425255
68MAP3K140.79204791
69DAPK10.78944313
70IRAK40.78348194
71YES10.78215015
72PIM10.78148341
73TAOK10.75978996
74NLK0.73823437
75CDC42BPA0.73761456
76PAK60.73755703
77PRKAA10.72897683
78TRPM70.71991968
79NEK60.70835146
80SIK10.70747384
81SGK20.70056238
82MAP3K10.69528075
83MAP3K80.68268960
84CSNK1D0.66852444
85PLK10.65253291
86RPS6KB10.65236382
87MAP2K30.65039691
88AURKB0.64400521
89MAP3K30.64142274
90MAPK140.64075984
91BRAF0.63900275
92UHMK10.63359257
93EPHA40.63039537
94STK100.61653896
95RET0.61039766
96PASK0.60181560
97* CDK10.59946508
98MAP3K70.59842719
99SGK4940.59706661
100SGK2230.59706661
101MARK20.59692567
102PTK20.58706305
103MATK0.58561928
104NEK10.58494074
105TTK0.58348988
106CDK40.58174647
107PDPK10.57609895
108EPHA20.57189142
109RAF10.56923266
110JAK10.55518885
111MAPK110.55145365
112IRAK20.54926116
113CSK0.54551119
114CAMKK10.54268596
115* MAPK100.54195243
116CAMK40.53563360
117PRKDC0.53497449
118RPS6KA20.51713513
119HIPK20.51157509
120JAK30.50099092
121* GSK3B0.48946970
122CSNK1E0.48027190
123PAK20.47889316
124PDK10.46738700
125EGFR0.44554895
126* RPS6KA30.44428419
127RPS6KA10.44164775
128* SGK10.44134185
129AKT10.43841850
130NTRK30.43442047
131STK110.43370492
132MAPK10.42976333
133MAP3K20.42386680
134RPS6KC10.42050066
135RPS6KL10.42050066
136ERBB30.41630416
137STK40.40927462
138MAPK80.40433548
139PLK30.40228627
140HCK0.40124349
141PTK60.38106080
142BTK0.38007735
143CHUK0.35133523

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.39807603
2mTOR signaling pathway_Homo sapiens_hsa041502.10539445
3Systemic lupus erythematosus_Homo sapiens_hsa053222.10323469
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.85696419
5Adherens junction_Homo sapiens_hsa045201.73671731
6MicroRNAs in cancer_Homo sapiens_hsa052061.59906852
7Alcoholism_Homo sapiens_hsa050341.58126544
8mRNA surveillance pathway_Homo sapiens_hsa030151.50589989
9Fatty acid biosynthesis_Homo sapiens_hsa000611.46380356
10Chronic myeloid leukemia_Homo sapiens_hsa052201.46225109
11Colorectal cancer_Homo sapiens_hsa052101.45992333
12Dorso-ventral axis formation_Homo sapiens_hsa043201.44052845
13Endometrial cancer_Homo sapiens_hsa052131.43856827
14Hippo signaling pathway_Homo sapiens_hsa043901.41974906
15Glioma_Homo sapiens_hsa052141.40026833
16Cell cycle_Homo sapiens_hsa041101.38330433
17Lysine degradation_Homo sapiens_hsa003101.37977158
18Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37886976
19Viral carcinogenesis_Homo sapiens_hsa052031.32481171
20Non-small cell lung cancer_Homo sapiens_hsa052231.28961369
21Notch signaling pathway_Homo sapiens_hsa043301.26292256
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24384583
23Oocyte meiosis_Homo sapiens_hsa041141.23771695
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22580619
25ErbB signaling pathway_Homo sapiens_hsa040121.21168157
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.20417223
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17694411
28TGF-beta signaling pathway_Homo sapiens_hsa043501.17526590
29RNA transport_Homo sapiens_hsa030131.17461813
30Proteoglycans in cancer_Homo sapiens_hsa052051.15539873
31Basal cell carcinoma_Homo sapiens_hsa052171.15512341
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.14895264
33Small cell lung cancer_Homo sapiens_hsa052221.13640530
34Estrogen signaling pathway_Homo sapiens_hsa049151.12961197
35Wnt signaling pathway_Homo sapiens_hsa043101.11686243
36Mismatch repair_Homo sapiens_hsa034301.10451610
37Long-term potentiation_Homo sapiens_hsa047201.08797755
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07961740
39Pancreatic cancer_Homo sapiens_hsa052121.06842619
40Olfactory transduction_Homo sapiens_hsa047401.06492737
41Hedgehog signaling pathway_Homo sapiens_hsa043401.06448584
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05685426
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.99901242
44Hepatitis C_Homo sapiens_hsa051600.99745178
45p53 signaling pathway_Homo sapiens_hsa041150.99229100
46Type II diabetes mellitus_Homo sapiens_hsa049300.98605169
47Measles_Homo sapiens_hsa051620.98517673
48Prostate cancer_Homo sapiens_hsa052150.97591234
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.97502569
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97078453
51VEGF signaling pathway_Homo sapiens_hsa043700.96300300
52Influenza A_Homo sapiens_hsa051640.95323977
53Osteoclast differentiation_Homo sapiens_hsa043800.93212675
54Choline metabolism in cancer_Homo sapiens_hsa052310.92601538
55Bladder cancer_Homo sapiens_hsa052190.92350023
56Focal adhesion_Homo sapiens_hsa045100.90997107
57Apoptosis_Homo sapiens_hsa042100.90934488
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90666363
59HTLV-I infection_Homo sapiens_hsa051660.90191350
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.88899702
61Circadian rhythm_Homo sapiens_hsa047100.88869219
62Fanconi anemia pathway_Homo sapiens_hsa034600.87025442
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86437099
64Thyroid cancer_Homo sapiens_hsa052160.86190957
65Toxoplasmosis_Homo sapiens_hsa051450.85220370
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.85117128
67GnRH signaling pathway_Homo sapiens_hsa049120.84543737
68Renal cell carcinoma_Homo sapiens_hsa052110.82859289
69Base excision repair_Homo sapiens_hsa034100.82690563
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82296370
71Gap junction_Homo sapiens_hsa045400.82278807
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80809874
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80344333
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.80063993
75Insulin resistance_Homo sapiens_hsa049310.79583636
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79571687
77Tight junction_Homo sapiens_hsa045300.79164112
78MAPK signaling pathway_Homo sapiens_hsa040100.79033127
79Viral myocarditis_Homo sapiens_hsa054160.78181147
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78178080
81Insulin signaling pathway_Homo sapiens_hsa049100.77710389
82FoxO signaling pathway_Homo sapiens_hsa040680.77379907
83TNF signaling pathway_Homo sapiens_hsa046680.77010152
84Rap1 signaling pathway_Homo sapiens_hsa040150.76631670
85Prolactin signaling pathway_Homo sapiens_hsa049170.76236408
86Melanogenesis_Homo sapiens_hsa049160.76227664
87Acute myeloid leukemia_Homo sapiens_hsa052210.75159848
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74656114
89Herpes simplex infection_Homo sapiens_hsa051680.73850978
90Pathways in cancer_Homo sapiens_hsa052000.73828269
91Dopaminergic synapse_Homo sapiens_hsa047280.73739868
92AMPK signaling pathway_Homo sapiens_hsa041520.73646442
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73029697
94Amoebiasis_Homo sapiens_hsa051460.72751648
95Glucagon signaling pathway_Homo sapiens_hsa049220.72549413
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72446813
97Hepatitis B_Homo sapiens_hsa051610.71953035
98Inositol phosphate metabolism_Homo sapiens_hsa005620.71482664
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71070869
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68848105
101Cholinergic synapse_Homo sapiens_hsa047250.68629826
102Oxytocin signaling pathway_Homo sapiens_hsa049210.68616423
103HIF-1 signaling pathway_Homo sapiens_hsa040660.68551011
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.66401740
105Melanoma_Homo sapiens_hsa052180.66087788
106Chemokine signaling pathway_Homo sapiens_hsa040620.64337004
107B cell receptor signaling pathway_Homo sapiens_hsa046620.64129972
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.63831517
109Amphetamine addiction_Homo sapiens_hsa050310.63777997
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63585372
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.63436437
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62611564
113Epstein-Barr virus infection_Homo sapiens_hsa051690.60095034
114Circadian entrainment_Homo sapiens_hsa047130.59956922
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59394932
116Axon guidance_Homo sapiens_hsa043600.59280468
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59181272
118Platelet activation_Homo sapiens_hsa046110.59121631
119T cell receptor signaling pathway_Homo sapiens_hsa046600.58324206
120Prion diseases_Homo sapiens_hsa050200.57703543
121DNA replication_Homo sapiens_hsa030300.57174892
122Endocytosis_Homo sapiens_hsa041440.56513994
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56057131
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55941290
125Non-homologous end-joining_Homo sapiens_hsa034500.55623962
126Leishmaniasis_Homo sapiens_hsa051400.54176628
127Long-term depression_Homo sapiens_hsa047300.52707730
128ECM-receptor interaction_Homo sapiens_hsa045120.50910693

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