TCF21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)7.72361861
2glomerular basement membrane development (GO:0032836)7.63792658
3glomerular visceral epithelial cell development (GO:0072015)7.18332641
4* glomerulus development (GO:0032835)6.50870425
5lymph vessel development (GO:0001945)6.32652512
6glomerular epithelial cell development (GO:0072310)6.31068514
7peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.16898371
8midgut development (GO:0007494)4.90148824
9endocardial cushion development (GO:0003197)4.88010035
10sequestering of extracellular ligand from receptor (GO:0035581)4.72717171
11extracellular fibril organization (GO:0043206)4.47745670
12* lung vasculature development (GO:0060426)4.41477791
13virion attachment to host cell (GO:0019062)4.29842839
14adhesion of symbiont to host cell (GO:0044650)4.29842839
15organ formation (GO:0048645)4.26808621
16cell proliferation involved in metanephros development (GO:0072203)4.18573971
17mesonephros development (GO:0001823)4.15481352
18muscle cell fate commitment (GO:0042693)4.12688160
19* respiratory tube development (GO:0030323)4.08065635
20metanephric mesenchyme development (GO:0072075)4.05583640
21lateral sprouting from an epithelium (GO:0060601)4.04857943
22dermatan sulfate biosynthetic process (GO:0030208)4.04017759
23regulation of smooth muscle cell differentiation (GO:0051150)3.97401340
24cell proliferation involved in kidney development (GO:0072111)3.94886184
25positive regulation of male gonad development (GO:2000020)3.93354046
26type B pancreatic cell proliferation (GO:0044342)3.92814026
27mesodermal cell differentiation (GO:0048333)3.89636769
28kidney mesenchyme development (GO:0072074)3.86772311
29dermatan sulfate metabolic process (GO:0030205)3.84422106
30venous blood vessel morphogenesis (GO:0048845)3.81968326
31lung lobe morphogenesis (GO:0060463)3.71234388
32fibril organization (GO:0097435)3.66499069
33protein heterotrimerization (GO:0070208)3.63279920
34vascular endothelial growth factor signaling pathway (GO:0038084)3.62992278
35axon extension involved in axon guidance (GO:0048846)3.61408216
36neuron projection extension involved in neuron projection guidance (GO:1902284)3.61408216
37adhesion of symbiont to host (GO:0044406)3.60451502
38bone trabecula formation (GO:0060346)3.56300313
39tonic smooth muscle contraction (GO:0014820)3.52647041
40renal filtration (GO:0097205)3.51392552
41collagen fibril organization (GO:0030199)3.50085542
42keratan sulfate catabolic process (GO:0042340)3.48067340
43pericardium development (GO:0060039)3.46606924
44lymphangiogenesis (GO:0001946)3.40595137
45extracellular matrix assembly (GO:0085029)3.37998214
46regulation of male gonad development (GO:2000018)3.36793471
47negative regulation of axon guidance (GO:1902668)3.35742975
48blood vessel maturation (GO:0001955)3.35674469
49establishment of apical/basal cell polarity (GO:0035089)3.35309478
50mesenchymal-epithelial cell signaling (GO:0060638)3.34923550
51positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.34708550
52basement membrane organization (GO:0071711)3.34227374
53glomerular filtration (GO:0003094)3.33072213
54mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.31277322
55chondrocyte proliferation (GO:0035988)3.30358887
56negative regulation of axon extension involved in axon guidance (GO:0048843)3.30229518
57embryonic foregut morphogenesis (GO:0048617)3.24321874
58insulin-like growth factor receptor signaling pathway (GO:0048009)3.22746388
59collagen metabolic process (GO:0032963)3.22596209
60atrioventricular valve morphogenesis (GO:0003181)3.22266110
61anatomical structure regression (GO:0060033)3.21056223
62polarized epithelial cell differentiation (GO:0030859)3.20801095
63negative regulation of chondrocyte differentiation (GO:0032331)3.20326970
64negative regulation of smooth muscle cell differentiation (GO:0051151)3.19960903
65negative regulation of catenin import into nucleus (GO:0035414)3.19817393
66multicellular organismal macromolecule metabolic process (GO:0044259)3.17603528
67metanephros development (GO:0001656)3.17527970
68regulation of endothelial cell differentiation (GO:0045601)3.16983288
69endothelial cell chemotaxis (GO:0035767)3.15251820
70organ induction (GO:0001759)3.14595455
71cell migration involved in heart development (GO:0060973)3.13984679
72positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.11096362
73endothelial cell morphogenesis (GO:0001886)3.10036941
74mesenchyme development (GO:0060485)3.06844268
75cardiac myofibril assembly (GO:0055003)3.06461492
76collagen catabolic process (GO:0030574)3.05909154
77multicellular organismal catabolic process (GO:0044243)3.05433853
78endodermal cell differentiation (GO:0035987)3.05104267
79adrenal gland development (GO:0030325)3.04705086
80multicellular organismal metabolic process (GO:0044236)3.03887704
81smooth muscle tissue development (GO:0048745)3.03298604
82growth hormone secretion (GO:0030252)3.01583638
83regulation of SMAD protein import into nucleus (GO:0060390)3.00407744
84epithelial cell differentiation involved in kidney development (GO:0035850)3.00150761
85regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.99370118
86maternal placenta development (GO:0001893)2.99032223
87regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.98800404
88regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.97388946
89regulation of cardioblast differentiation (GO:0051890)2.96694824
90outflow tract septum morphogenesis (GO:0003148)2.94692594
91coronary vasculature morphogenesis (GO:0060977)2.93579489
92negative regulation of leukocyte chemotaxis (GO:0002689)2.91421617
93mesenchymal cell proliferation (GO:0010463)2.90905510
94extracellular matrix disassembly (GO:0022617)2.90844950
95retina vasculature morphogenesis in camera-type eye (GO:0061299)2.89132503
96renal system development (GO:0072001)2.88735211
97extracellular regulation of signal transduction (GO:1900115)2.86669508
98extracellular negative regulation of signal transduction (GO:1900116)2.86669508
99regulation of organ formation (GO:0003156)2.84230913
100* lung alveolus development (GO:0048286)2.83321845
101cell migration involved in sprouting angiogenesis (GO:0002042)2.82084057
102regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.81360444
103regulation of extracellular matrix disassembly (GO:0010715)2.81286193
104regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.79871176
105regulation of response to osmotic stress (GO:0047484)2.79247929
106establishment of monopolar cell polarity (GO:0061162)2.78961602
107establishment or maintenance of monopolar cell polarity (GO:0061339)2.78961602
108neural crest cell development (GO:0014032)2.78100183
109* embryonic digestive tract morphogenesis (GO:0048557)2.77847055
110regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.77083160
111positive regulation of endothelial cell differentiation (GO:0045603)2.77065226
112* mesonephric tubule development (GO:0072164)2.76261131
113barbed-end actin filament capping (GO:0051016)2.76068490
114growth hormone receptor signaling pathway (GO:0060396)2.76055323
115* mesonephric epithelium development (GO:0072163)2.73832319
116nephron epithelium morphogenesis (GO:0072088)2.73760775
117nephron tubule morphogenesis (GO:0072078)2.73760775
118cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.73544698
119vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.73092725
120artery development (GO:0060840)2.72631375
121* branching involved in ureteric bud morphogenesis (GO:0001658)2.72542683
122regulation of axon guidance (GO:1902667)2.72250408
123chondroitin sulfate catabolic process (GO:0030207)2.71585177
124radial glial cell differentiation (GO:0060019)2.71397376
125surfactant homeostasis (GO:0043129)2.71240612
126patterning of blood vessels (GO:0001569)2.71105360
127negative regulation of smooth muscle cell migration (GO:0014912)2.68732305
128* ureteric bud development (GO:0001657)2.68379435
129regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.68222776
130metanephric epithelium development (GO:0072207)2.67807875
131negative regulation of complement activation (GO:0045916)2.67801718
132endocardial cushion morphogenesis (GO:0003203)2.67686297
133extracellular matrix organization (GO:0030198)2.67554287
134endothelial cell proliferation (GO:0001935)2.66738276
135extracellular structure organization (GO:0043062)2.66568748
136positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.66449054
137blood vessel remodeling (GO:0001974)2.66007183
138positive regulation of Rho protein signal transduction (GO:0035025)2.65271753
139skin morphogenesis (GO:0043589)2.64078550
140regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64062797
141planar cell polarity pathway involved in neural tube closure (GO:0090179)2.62651866
142positive regulation of endothelial cell apoptotic process (GO:2000353)2.60375885
143positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.56677634
144cGMP-mediated signaling (GO:0019934)2.54067175
145tooth mineralization (GO:0034505)2.53631399
146neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.51724101
147negative regulation of cartilage development (GO:0061037)2.50298654
148mesenchyme morphogenesis (GO:0072132)2.49866875
149regulation of integrin-mediated signaling pathway (GO:2001044)2.49419335
150positive regulation of cardiac muscle tissue development (GO:0055025)2.46605280
151substrate adhesion-dependent cell spreading (GO:0034446)2.43197762
152positive regulation of mesenchymal cell proliferation (GO:0002053)2.42842091
153artery morphogenesis (GO:0048844)2.41327302
154regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40395041
155regulation of metanephros development (GO:0072215)2.39792981
156trabecula formation (GO:0060343)2.39418797
157negative regulation of osteoblast proliferation (GO:0033689)2.39334000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.47046192
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.38372890
3CLOCK_20551151_ChIP-Seq_293T_Human4.26977880
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.96701526
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.85403363
6EP300_21415370_ChIP-Seq_HL-1_Mouse3.15003094
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.12661509
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.04101120
9WT1_19549856_ChIP-ChIP_CCG9911_Human3.02714597
10* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.99962517
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.97408473
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.80374420
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.57088587
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.52267287
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.42995117
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.32691719
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.30908003
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.30057424
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.25336666
20* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15442825
21ISL1_27105846_Chip-Seq_CPCs_Mouse1.94624689
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.91263602
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.90113115
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87726842
25GATA1_22025678_ChIP-Seq_K562_Human1.85944918
26CJUN_26792858_Chip-Seq_BT549_Human1.79831665
27* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77160528
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76041564
29VDR_22108803_ChIP-Seq_LS180_Human1.75584814
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74517404
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74517404
32* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72823677
33* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70627995
34DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.70361248
35EZH2_22144423_ChIP-Seq_EOC_Human1.70230072
36BRD4_25478319_ChIP-Seq_HGPS_Human1.69679910
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68090554
38LXR_22158963_ChIP-Seq_LIVER_Mouse1.67931775
39* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67731169
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.67507409
41* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.64432240
42AR_21909140_ChIP-Seq_LNCAP_Human1.62361735
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.62287412
44* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.60935089
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59270354
46* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57239397
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.56112272
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.55967015
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53850526
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.50088512
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.48171476
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.48171476
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46662546
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46553022
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44047053
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39790606
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38924242
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.36386792
59SOX2_20726797_ChIP-Seq_SW620_Human1.36379266
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.36341170
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33476772
62SMC1_22415368_ChIP-Seq_MEFs_Mouse1.32479745
63TP53_18474530_ChIP-ChIP_U2OS_Human1.31731434
64* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30470140
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30308520
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30219663
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.29309652
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28919326
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28919326
70* TP53_20018659_ChIP-ChIP_R1E_Mouse1.26266217
71* EZH2_27294783_Chip-Seq_ESCs_Mouse1.22638263
72SMC3_22415368_ChIP-Seq_MEFs_Mouse1.22492170
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22286567
74MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.20269650
75* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20108901
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19633973
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.19155939
78* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18615280
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15161404
80* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14189254
81* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13170607
82TP53_16413492_ChIP-PET_HCT116_Human1.12368037
83DROSHA_22980978_ChIP-Seq_HELA_Human1.11672409
84EZH2_27304074_Chip-Seq_ESCs_Mouse1.07944413
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07775338
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07440852
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06522661
88LXR_22292898_ChIP-Seq_THP-1_Human1.06426631
89ELK3_25401928_ChIP-Seq_HUVEC_Human1.05175212
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04805070
91* RING1B_27294783_Chip-Seq_ESCs_Mouse1.03722819
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02589875
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00727159
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00670819
95BCAT_22108803_ChIP-Seq_LS180_Human1.00005247
96HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99481544
97AR_21572438_ChIP-Seq_LNCaP_Human0.98473693
98FOXA2_19822575_ChIP-Seq_HepG2_Human0.98370494
99TP53_22127205_ChIP-Seq_IMR90_Human0.98194565
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98037309
101FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97011409
102* RING1B_27294783_Chip-Seq_NPCs_Mouse0.95574762
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95181281
104PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95073078
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94872344
106* CBX2_27304074_Chip-Seq_ESCs_Mouse0.94765839
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94465205
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93948238
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93319293
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91872053
111TP53_23651856_ChIP-Seq_MEFs_Mouse0.91225207
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91126278
113TCF4_18268006_ChIP-ChIP_LS174T_Human0.90794687
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.90272342
115STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89959742
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89583827
117GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89530127
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88773818
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.88251498
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88099162
121NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87411534
122* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87256820
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86606792
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.86391910
125SA1_22415368_ChIP-Seq_MEFs_Mouse0.85131479
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83857950
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83694180
128VDR_24787735_ChIP-Seq_THP-1_Human0.83133358
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82776601
130AHR_22903824_ChIP-Seq_MCF-7_Human0.82692525
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81912710
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81912710
133* GATA4_25053715_ChIP-Seq_YYC3_Human0.79016333
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78987155
135* RNF2_27304074_Chip-Seq_ESCs_Mouse0.78303154
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77855341
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.77572875

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.10019437
2MP0005275_abnormal_skin_tensile4.39902792
3MP0005503_abnormal_tendon_morphology4.24070429
4MP0004272_abnormal_basement_membrane3.72373417
5MP0010368_abnormal_lymphatic_system3.66932653
6MP0001879_abnormal_lymphatic_vessel3.29922674
7MP0005257_abnormal_intraocular_pressure3.12873812
8MP0009384_cardiac_valve_regurgitation3.06265314
9MP0003122_maternal_imprinting2.77669133
10MP0001958_emphysema2.70109611
11MP0000534_abnormal_ureter_morphology2.67146137
12* MP0003115_abnormal_respiratory_system2.51566167
13MP0000537_abnormal_urethra_morphology2.40302909
14MP0003123_paternal_imprinting2.13393786
15MP0001542_abnormal_bone_strength2.12866007
16* MP0003942_abnormal_urinary_system2.07587470
17MP0002282_abnormal_trachea_morphology2.04326633
18MP0003385_abnormal_body_wall2.01602872
19MP0005367_renal/urinary_system_phenotyp1.95925950
20MP0000516_abnormal_urinary_system1.95925950
21MP0006138_congestive_heart_failure1.94464693
22MP0005623_abnormal_meninges_morphology1.93782547
23MP0002249_abnormal_larynx_morphology1.84155321
24MP0009053_abnormal_anal_canal1.84074042
25MP0003705_abnormal_hypodermis_morpholog1.81737793
26MP0008004_abnormal_stomach_pH1.78909220
27MP0002132_abnormal_respiratory_system1.68297363
28MP0009250_abnormal_appendicular_skeleto1.66074450
29MP0000767_abnormal_smooth_muscle1.63354971
30MP0002295_abnormal_pulmonary_circulatio1.58988238
31MP0005508_abnormal_skeleton_morphology1.58351475
32MP0003828_pulmonary_edema1.56360320
33MP0005360_urolithiasis1.53268813
34MP0003091_abnormal_cell_migration1.51760752
35MP0010030_abnormal_orbit_morphology1.48898908
36MP0002896_abnormal_bone_mineralization1.46660902
37MP0002108_abnormal_muscle_morphology1.45906001
38MP0003279_aneurysm1.45368339
39MP0001664_abnormal_digestion1.43054979
40MP0005248_abnormal_Harderian_gland1.42854446
41MP0003566_abnormal_cell_adhesion1.42687009
42MP0006054_spinal_hemorrhage1.42677024
43MP0005390_skeleton_phenotype1.39408606
44MP0003119_abnormal_digestive_system1.38412838
45MP0001986_abnormal_taste_sensitivity1.38399444
46MP0000751_myopathy1.29012627
47MP0002933_joint_inflammation1.28472818
48MP0002133_abnormal_respiratory_system1.25759661
49MP0005388_respiratory_system_phenotype1.25759661
50MP0003121_genomic_imprinting1.25724372
51MP0002139_abnormal_hepatobiliary_system1.24291160
52MP0003950_abnormal_plasma_membrane1.23497920
53MP0010386_abnormal_urinary_bladder1.23491897
54MP0000003_abnormal_adipose_tissue1.22804566
55* MP0001175_abnormal_lung_morphology1.21742655
56MP0004084_abnormal_cardiac_muscle1.21330442
57MP0000428_abnormal_craniofacial_morphol1.20040939
58MP0002127_abnormal_cardiovascular_syste1.17164258
59MP0003315_abnormal_perineum_morphology1.14827627
60* MP0002128_abnormal_blood_circulation1.13589302
61MP0003941_abnormal_skin_development1.12901649
62MP0001243_abnormal_dermal_layer1.12360089
63MP0001299_abnormal_eye_distance/1.11790673
64MP0005385_cardiovascular_system_phenoty1.11233826
65MP0001544_abnormal_cardiovascular_syste1.11233826
66MP0000678_abnormal_parathyroid_gland1.08162694
67MP0001756_abnormal_urination1.06955688
68MP0003252_abnormal_bile_duct1.06378869
69MP0002009_preneoplasia1.05944767
70MP0002938_white_spotting1.05162283
71MP0009780_abnormal_chondrocyte_physiolo1.04298642
72MP0002102_abnormal_ear_morphology1.04215926
73MP0000013_abnormal_adipose_tissue1.04205865
74MP0003935_abnormal_craniofacial_develop1.03840862
75MP0004036_abnormal_muscle_relaxation1.03498292
76MP0000681_abnormal_thyroid_gland1.00656611
77MP0005164_abnormal_response_to1.00375655
78MP0001849_ear_inflammation0.99165343
79* MP0001614_abnormal_blood_vessel0.98538402
80MP0002932_abnormal_joint_morphology0.98431769
81* MP0002135_abnormal_kidney_morphology0.98318742
82MP0000538_abnormal_urinary_bladder0.97555215
83MP0002998_abnormal_bone_remodeling0.96314694
84MP0003724_increased_susceptibility_to0.95172363
85MP0001177_atelectasis0.94128607
86MP0008875_abnormal_xenobiotic_pharmacok0.93574240
87MP0002925_abnormal_cardiovascular_devel0.91379835
88MP0000230_abnormal_systemic_arterial0.90340352
89MP0005085_abnormal_gallbladder_physiolo0.89376627
90MP0001533_abnormal_skeleton_physiology0.89321011
91MP0003567_abnormal_fetal_cardiomyocyte0.89182254
92MP0004782_abnormal_surfactant_physiolog0.89007885
93MP0008995_early_reproductive_senescence0.87644927
94MP0000049_abnormal_middle_ear0.87639345
95MP0004858_abnormal_nervous_system0.86677283
96MP0002060_abnormal_skin_morphology0.86492603
97MP0004019_abnormal_vitamin_homeostasis0.86333358
98MP0000163_abnormal_cartilage_morphology0.86089494
99MP0009840_abnormal_foam_cell0.84410864
100MP0001270_distended_abdomen0.84382915
101MP0000613_abnormal_salivary_gland0.83763520
102MP0010630_abnormal_cardiac_muscle0.82869589
103MP0005023_abnormal_wound_healing0.82699298
104MP0005167_abnormal_blood-brain_barrier0.82293774
105MP0001661_extended_life_span0.81410270
106* MP0000266_abnormal_heart_morphology0.80984231
107MP0003937_abnormal_limbs/digits/tail_de0.79689590
108MP0003943_abnormal_hepatobiliary_system0.79478894
109MP0010352_gastrointestinal_tract_polyps0.78704383
110MP0002115_abnormal_skeleton_extremities0.78437876
111MP0005330_cardiomyopathy0.76640803
112MP0005332_abnormal_amino_acid0.76141639
113MP0005595_abnormal_vascular_smooth0.75881671
114MP0000432_abnormal_head_morphology0.75585708
115MP0008775_abnormal_heart_ventricle0.75121033
116MP0000462_abnormal_digestive_system0.74790943
117MP0004197_abnormal_fetal_growth/weight/0.74571252
118MP0000470_abnormal_stomach_morphology0.74500171
119MP0000733_abnormal_muscle_development0.73452874
120MP0003137_abnormal_impulse_conducting0.72573652
121MP0003755_abnormal_palate_morphology0.71668418
122MP0009697_abnormal_copulation0.71560435
123MP0003283_abnormal_digestive_organ0.71207380
124MP0004883_abnormal_blood_vessel0.70744581
125MP0004484_altered_response_of0.70486857
126MP0005620_abnormal_muscle_contractility0.69157015
127MP0005083_abnormal_biliary_tract0.68665608
128MP0002972_abnormal_cardiac_muscle0.67893168
129MP0002113_abnormal_skeleton_development0.67690755
130MP0002109_abnormal_limb_morphology0.66665169
131MP0000762_abnormal_tongue_morphology0.66284266
132MP0005197_abnormal_uvea_morphology0.64697521
133MP0003448_altered_tumor_morphology0.63662616
134MP0002116_abnormal_craniofacial_bone0.61980439
135MP0005670_abnormal_white_adipose0.61958888
136MP0000249_abnormal_blood_vessel0.61111688
137MP0003795_abnormal_bone_structure0.57664934
138MP0001666_abnormal_nutrient_absorption0.55330105
139MP0002089_abnormal_postnatal_growth/wei0.54835953
140MP0003938_abnormal_ear_development0.53242479
141MP0004085_abnormal_heartbeat0.52690333

Predicted human phenotypes

RankGene SetZ-score
1Hypoplastic left heart (HP:0004383)5.59070426
2Vascular tortuosity (HP:0004948)5.20068365
3Mesangial abnormality (HP:0001966)4.84018884
4Ankle contracture (HP:0006466)4.48179326
5Arterial tortuosity (HP:0005116)4.45312707
6Aortic aneurysm (HP:0004942)4.40989286
7Hypoplastic heart (HP:0001961)4.18630560
8Protrusio acetabuli (HP:0003179)4.18324616
9Lymphangioma (HP:0100764)4.11595245
10Broad metatarsal (HP:0001783)4.04858582
11Hepatoblastoma (HP:0002884)3.92021346
12Soft skin (HP:0000977)3.87944499
13Aortic dissection (HP:0002647)3.81817773
14Focal segmental glomerulosclerosis (HP:0000097)3.77816903
15Cervical subluxation (HP:0003308)3.66843656
16Shawl scrotum (HP:0000049)3.64398549
17Renal duplication (HP:0000075)3.62662636
18Back pain (HP:0003418)3.53739612
19Diastasis recti (HP:0001540)3.38189884
20Abnormality of the pulmonary veins (HP:0011718)3.37155528
21Rectal prolapse (HP:0002035)3.35494211
22Enlarged kidneys (HP:0000105)3.29247006
23Abnormality of incisor morphology (HP:0011063)3.22450053
24Spinal rigidity (HP:0003306)3.22081164
25Wormian bones (HP:0002645)3.13491256
26Glomerulosclerosis (HP:0000096)3.10145531
27Neonatal short-limb short stature (HP:0008921)3.04494170
28Vertebral compression fractures (HP:0002953)3.01258496
29Spondylolisthesis (HP:0003302)3.00151071
30Broad toe (HP:0001837)2.97780975
31Increased variability in muscle fiber diameter (HP:0003557)2.92443614
32Atrophic scars (HP:0001075)2.92069359
33Dilatation of the ascending aorta (HP:0005111)2.91095294
34Nasolacrimal duct obstruction (HP:0000579)2.87890085
35Embryonal renal neoplasm (HP:0011794)2.85779476
36Hematochezia (HP:0002573)2.85716221
37Camptodactyly of toe (HP:0001836)2.84833869
38Glomerulonephritis (HP:0000099)2.80725484
39Midline defect of the nose (HP:0004122)2.79362179
40Joint laxity (HP:0001388)2.76486345
41Fragile skin (HP:0001030)2.75344930
42Abnormality of dentin (HP:0010299)2.74623661
43Hypoventilation (HP:0002791)2.74335606
44Deep venous thrombosis (HP:0002625)2.74224446
45Potter facies (HP:0002009)2.68673943
46Facial shape deformation (HP:0011334)2.68673943
47Mildly elevated creatine phosphokinase (HP:0008180)2.68008869
48Short 4th metacarpal (HP:0010044)2.66615650
49Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66615650
50Abnormal umbilical cord blood vessels (HP:0011403)2.66469416
51Single umbilical artery (HP:0001195)2.66469416
52Abnormality of the fetal cardiovascular system (HP:0010948)2.66469416
53Pulmonary artery stenosis (HP:0004415)2.64694580
54Long toe (HP:0010511)2.60811084
55Abnormality of the lacrimal duct (HP:0011481)2.56724762
56Overgrowth (HP:0001548)2.53973501
57Abnormality of the nasolacrimal system (HP:0000614)2.52239727
58Nephritis (HP:0000123)2.51776555
59Emphysema (HP:0002097)2.51692407
60Peritonitis (HP:0002586)2.51613899
61Hypoalbuminemia (HP:0003073)2.51142797
62Abnormal albumin level (HP:0012116)2.51142797
63Systemic lupus erythematosus (HP:0002725)2.47933217
64Mitral valve prolapse (HP:0001634)2.46741992
65Recurrent corneal erosions (HP:0000495)2.43961548
66Aortic regurgitation (HP:0001659)2.43090047
67Hyperextensible skin (HP:0000974)2.42031896
68Abnormality of complement system (HP:0005339)2.41577195
69Osteolytic defects of the hand bones (HP:0009699)2.38897711
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.38897711
71Visceral angiomatosis (HP:0100761)2.38354468
72Shallow orbits (HP:0000586)2.36543391
73Thin bony cortex (HP:0002753)2.36033453
74Abnormality of skeletal muscle fiber size (HP:0012084)2.35126759
75Wide anterior fontanel (HP:0000260)2.31181070
76Cerebral aneurysm (HP:0004944)2.30448620
77Type 1 muscle fiber predominance (HP:0003803)2.28655113
78Genu recurvatum (HP:0002816)2.28585560
79Hemangiomatosis (HP:0007461)2.24835427
80Bowel diverticulosis (HP:0005222)2.21975547
81Follicular hyperkeratosis (HP:0007502)2.20037991
82Preaxial foot polydactyly (HP:0001841)2.19837219
83Coronal craniosynostosis (HP:0004440)2.16994806
84Partial duplication of thumb phalanx (HP:0009944)2.16049157
85Flexion contracture of toe (HP:0005830)2.15535055
86Joint contractures involving the joints of the feet (HP:0100492)2.15535055
87Persistence of primary teeth (HP:0006335)2.15371403
88Keratoconus (HP:0000563)2.14615722
89Increased corneal curvature (HP:0100692)2.14615722
90Bronchomalacia (HP:0002780)2.14318622
91Thoracolumbar scoliosis (HP:0002944)2.13757316
92Broad hallux (HP:0010055)2.11926569
93Arachnodactyly (HP:0001166)2.11511869
94Elbow flexion contracture (HP:0002987)2.11182393
95Aortic valve stenosis (HP:0001650)2.09582280
96Protruding ear (HP:0000411)2.09037909
97Cardiovascular calcification (HP:0011915)2.07848266
98Pancreatic islet-cell hyperplasia (HP:0004510)2.06289476
99Aneurysm (HP:0002617)2.05048309
100Nephroblastoma (Wilms tumor) (HP:0002667)2.05043099
101Bell-shaped thorax (HP:0001591)2.05031323
102Hip contracture (HP:0003273)2.02707481
103Stage 5 chronic kidney disease (HP:0003774)2.02531927
104Narrow nasal bridge (HP:0000446)2.01473975
105Redundant skin (HP:0001582)1.98951396
106Bladder diverticulum (HP:0000015)1.97630403
107Joint stiffness (HP:0001387)1.97328545
108Abnormality of the 4th metacarpal (HP:0010012)1.96166955
109Premature rupture of membranes (HP:0001788)1.95975833
110Aplasia involving bones of the extremities (HP:0009825)1.94355398
111Aplasia involving bones of the upper limbs (HP:0009823)1.94355398
112Aplasia of the phalanges of the hand (HP:0009802)1.94355398
113Partial duplication of the phalanx of hand (HP:0009999)1.92278715
114Mitral stenosis (HP:0001718)1.91980219
115Patent foramen ovale (HP:0001655)1.90896464
116Complement deficiency (HP:0004431)1.89947461
117Limited hip movement (HP:0008800)1.89874585
118Neoplasm of the heart (HP:0100544)1.89786442
119Striae distensae (HP:0001065)1.88622000
120Ectopia lentis (HP:0001083)1.87923562
121Abnormality of the acetabulum (HP:0003170)1.87109584
122Atrioventricular canal defect (HP:0006695)1.86258767
123Delayed cranial suture closure (HP:0000270)1.85036216
124Mitral regurgitation (HP:0001653)1.84734864
125Metaphyseal dysplasia (HP:0100255)1.83967511
126Pulmonary hypertension (HP:0002092)1.83639294
127Round ear (HP:0100830)1.83600840
128Slender build (HP:0001533)1.83058601
129Tarsal synostosis (HP:0008368)1.82498876
130Short hallux (HP:0010109)1.81865973
131Abnormal lung lobation (HP:0002101)1.81843859
132Testicular neoplasm (HP:0010788)1.81828799
133Neoplasm of the liver (HP:0002896)1.81810073
134Neonatal death (HP:0003811)1.80575998
135Hypokalemic alkalosis (HP:0001949)1.79740692
136Inguinal hernia (HP:0000023)1.79377116
137Spontaneous hematomas (HP:0007420)1.79326856
138Mesomelia (HP:0003027)1.79117732
139Blue sclerae (HP:0000592)1.78895315
140Knee flexion contracture (HP:0006380)1.78162203
141Abnormality of the incisor (HP:0000676)1.77936238
142Polycythemia (HP:0001901)1.77172052
143Disproportionate tall stature (HP:0001519)1.76677507
144Wrist flexion contracture (HP:0001239)1.74156857
145Flat capital femoral epiphysis (HP:0003370)1.73724956
146Delayed closure of the anterior fontanelle (HP:0001476)1.72317809
147Abnormality of the umbilical cord (HP:0010881)1.71874723
148Hydroxyprolinuria (HP:0003080)1.71413998
149Annular pancreas (HP:0001734)1.69780514
150Hydroureter (HP:0000072)1.68502897
151Abnormal ventriculo-arterial connection (HP:0011563)1.67145141
152Transposition of the great arteries (HP:0001669)1.67145141
153Abnormal connection of the cardiac segments (HP:0011545)1.67145141
154Bicornuate uterus (HP:0000813)1.65491968
155Xerostomia (HP:0000217)1.65337327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK6.50467084
2EPHA36.03856733
3TIE13.17532965
4PTK2B3.02717782
5PIK3CG2.99831475
6TGFBR22.74917863
7EPHB22.66528657
8GRK12.54676451
9TTN2.39944418
10PDGFRA2.38366293
11GRK72.32906825
12MET2.25517053
13LATS22.22554583
14ADRBK22.22347594
15TRIB32.07385340
16ZAK2.02623725
17WNK41.97622454
18LATS11.97274567
19FGFR41.86728773
20KIT1.82237224
21AKT31.79617494
22TGFBR11.77882621
23GRK61.73411638
24STK38L1.71706751
25ADRBK11.71688390
26RIPK11.68516495
27NTRK11.68179164
28DMPK1.67685125
29PAK41.64389492
30TESK11.62743108
31PAK21.57011803
32ROCK11.48237115
33PIK3CA1.46966222
34ILK1.45416451
35PTK61.39634368
36RPS6KA21.27658712
37STK381.24795879
38ERBB31.24459728
39PRKG21.23759044
40PDGFRB1.18327347
41KDR1.17006961
42BCKDK1.15822343
43STK391.12927979
44FGFR21.09795254
45PTK21.08083841
46FER1.06689920
47GRK51.04375164
48STK241.01919496
49MAPK71.00934540
50NUAK10.99895993
51PKN20.99427247
52ABL20.99339816
53LRRK20.98757837
54JAK10.97079414
55EPHB10.96295469
56ERN10.95535101
57ERBB40.95441598
58FRK0.94938499
59CAMK40.89411510
60BMX0.87598299
61ACVR1B0.85172455
62GSK3A0.82271060
63OXSR10.81859118
64MAP3K100.79726063
65NLK0.77749737
66MELK0.77718887
67CCNB10.76033932
68DAPK30.75864091
69WNK30.75238781
70MAP2K20.73667766
71LMTK20.72482761
72STK30.71036179
73RPS6KA60.68701321
74MAP3K60.66370739
75CSF1R0.66275704
76DDR20.65809080
77MAPK130.64087873
78CAMK2G0.61462230
79NEK90.61387163
80PDPK10.60488860
81ICK0.60355676
82MKNK10.60036218
83LIMK10.59162896
84PRKCZ0.59099808
85SGK30.57224106
86TRPM70.56451339
87PAK30.56125407
88CLK10.55126784
89WNK10.54511386
90MAPKAPK30.53193323
91MARK20.53076595
92DYRK1B0.52812951
93MAP3K30.52057600
94PKN10.51794610
95INSRR0.51713973
96PRKCE0.48960138
97PLK20.48061405
98PRKCH0.47829164
99SIK10.45919772
100BUB10.45791037
101PRKD10.44855322
102MAP3K70.44408168
103TYK20.43802923
104CAMK1D0.42069742
105IGF1R0.41962027
106PAK10.41107561
107SGK20.40525490
108MAPKAPK20.39526755
109CDK70.39420100
110CAMKK20.38836835
111MAP2K10.37254325
112PIM20.35351419
113CDC42BPA0.34842882
114PLK40.34686643
115SRC0.34601987
116BRSK20.34596883
117STK40.34487779
118FGFR10.34375732
119MAPK40.33312254
120MAPK150.33192703
121ROCK20.32776498
122PRKACB0.32122796
123PRKAA20.30886315
124MST1R0.30752647
125MKNK20.30643649
126CAMK2B0.30128038
127PRKCD0.29967356
128FLT30.29245275
129RET0.28962564
130MAPK10.27840305
131EEF2K0.27257862
132PRKD20.27000283
133PRPF4B0.26590723
134ERBB20.26572184
135MTOR0.26296968
136PRKCI0.25464996
137RPS6KC10.25335906
138RPS6KL10.25335906
139CDK80.25244024
140PRKG10.24875776
141MUSK0.24654426
142NEK60.24190651
143INSR0.23590747

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.18149053
2Focal adhesion_Homo sapiens_hsa045102.61435665
3Fatty acid degradation_Homo sapiens_hsa000712.59552816
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29820331
5TGF-beta signaling pathway_Homo sapiens_hsa043502.29235110
6Small cell lung cancer_Homo sapiens_hsa052222.04487147
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.03549320
8Adherens junction_Homo sapiens_hsa045202.00479974
9Dilated cardiomyopathy_Homo sapiens_hsa054142.00475589
10Protein digestion and absorption_Homo sapiens_hsa049741.96593717
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.96135297
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.95185719
13Complement and coagulation cascades_Homo sapiens_hsa046101.94988988
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.94576276
15Fatty acid metabolism_Homo sapiens_hsa012121.91082397
16Propanoate metabolism_Homo sapiens_hsa006401.89965762
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.83309705
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.80335729
19Tryptophan metabolism_Homo sapiens_hsa003801.65738717
20Basal cell carcinoma_Homo sapiens_hsa052171.62973988
21Hedgehog signaling pathway_Homo sapiens_hsa043401.62885503
22Amoebiasis_Homo sapiens_hsa051461.60758774
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54950547
24Lysine degradation_Homo sapiens_hsa003101.54915577
25PPAR signaling pathway_Homo sapiens_hsa033201.54087550
26Hippo signaling pathway_Homo sapiens_hsa043901.53795469
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48234048
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.46636080
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46422453
30Mineral absorption_Homo sapiens_hsa049781.46027295
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44407824
32Proteoglycans in cancer_Homo sapiens_hsa052051.39108434
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35013614
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.34483209
35Fatty acid elongation_Homo sapiens_hsa000621.32738420
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28547476
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26797131
38Axon guidance_Homo sapiens_hsa043601.26275340
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.23669539
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20664632
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19825873
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19377564
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.18456385
44Other glycan degradation_Homo sapiens_hsa005111.17979595
45Pertussis_Homo sapiens_hsa051331.17153177
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15602261
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15207715
48Chemical carcinogenesis_Homo sapiens_hsa052041.12647125
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12012457
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11967536
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11425328
52PI3K-Akt signaling pathway_Homo sapiens_hsa041511.10180087
53Prostate cancer_Homo sapiens_hsa052151.08969939
54Prion diseases_Homo sapiens_hsa050201.07011507
55Fat digestion and absorption_Homo sapiens_hsa049751.06406263
56Retinol metabolism_Homo sapiens_hsa008301.06114484
57Starch and sucrose metabolism_Homo sapiens_hsa005001.05622761
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04809595
59Pathways in cancer_Homo sapiens_hsa052001.04345466
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03113784
61Peroxisome_Homo sapiens_hsa041461.01092721
62Renin-angiotensin system_Homo sapiens_hsa046141.00188414
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99303479
64Renin secretion_Homo sapiens_hsa049240.97867966
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97647082
66Glutathione metabolism_Homo sapiens_hsa004800.97230078
67Tight junction_Homo sapiens_hsa045300.93484968
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93261118
69Butanoate metabolism_Homo sapiens_hsa006500.91438853
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.91407267
71Ovarian steroidogenesis_Homo sapiens_hsa049130.91330576
72Cocaine addiction_Homo sapiens_hsa050300.91242207
73beta-Alanine metabolism_Homo sapiens_hsa004100.88186303
74MicroRNAs in cancer_Homo sapiens_hsa052060.85731798
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.84582436
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84492323
77Insulin resistance_Homo sapiens_hsa049310.82916438
78Platelet activation_Homo sapiens_hsa046110.81594552
79Selenocompound metabolism_Homo sapiens_hsa004500.81224484
80Notch signaling pathway_Homo sapiens_hsa043300.79703137
81Arachidonic acid metabolism_Homo sapiens_hsa005900.75873963
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74797196
83Bile secretion_Homo sapiens_hsa049760.74662591
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74657345
85Malaria_Homo sapiens_hsa051440.74400168
86Calcium signaling pathway_Homo sapiens_hsa040200.72887553
87Rap1 signaling pathway_Homo sapiens_hsa040150.71874761
88Viral myocarditis_Homo sapiens_hsa054160.70843579
89GnRH signaling pathway_Homo sapiens_hsa049120.70493427
90Staphylococcus aureus infection_Homo sapiens_hsa051500.69531064
91Bladder cancer_Homo sapiens_hsa052190.67207691
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66851087
93Estrogen signaling pathway_Homo sapiens_hsa049150.66742551
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66459406
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66001492
96Thyroid hormone synthesis_Homo sapiens_hsa049180.65116334
97Ras signaling pathway_Homo sapiens_hsa040140.64718414
98Pancreatic secretion_Homo sapiens_hsa049720.61706506
99Vitamin digestion and absorption_Homo sapiens_hsa049770.61159493
100Melanogenesis_Homo sapiens_hsa049160.60572357
101Carbon metabolism_Homo sapiens_hsa012000.60456438
102Toxoplasmosis_Homo sapiens_hsa051450.59186916
103Gap junction_Homo sapiens_hsa045400.56623681
104Lysosome_Homo sapiens_hsa041420.55819218
105Base excision repair_Homo sapiens_hsa034100.55528235
106ABC transporters_Homo sapiens_hsa020100.55431476
107Wnt signaling pathway_Homo sapiens_hsa043100.55293970
108Nitrogen metabolism_Homo sapiens_hsa009100.54719622
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54583376
110Chronic myeloid leukemia_Homo sapiens_hsa052200.54024400
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53973681
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53581741
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53260560
114Insulin secretion_Homo sapiens_hsa049110.52637833
115Choline metabolism in cancer_Homo sapiens_hsa052310.51832632
116Melanoma_Homo sapiens_hsa052180.50939930
117N-Glycan biosynthesis_Homo sapiens_hsa005100.50703698
118Cholinergic synapse_Homo sapiens_hsa047250.50661109
119Pyruvate metabolism_Homo sapiens_hsa006200.50607113
120mTOR signaling pathway_Homo sapiens_hsa041500.50041667
121Renal cell carcinoma_Homo sapiens_hsa052110.49896139
122TNF signaling pathway_Homo sapiens_hsa046680.49629230
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49601371
124Endometrial cancer_Homo sapiens_hsa052130.48597879
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48240679
126Histidine metabolism_Homo sapiens_hsa003400.47092141
127MAPK signaling pathway_Homo sapiens_hsa040100.46436743
128Endocytosis_Homo sapiens_hsa041440.46311127
129Sulfur metabolism_Homo sapiens_hsa009200.46211632
130Oxytocin signaling pathway_Homo sapiens_hsa049210.45510352
131Phenylalanine metabolism_Homo sapiens_hsa003600.44631126
132Arginine biosynthesis_Homo sapiens_hsa002200.44240896
133Arginine and proline metabolism_Homo sapiens_hsa003300.40044058
134Glucagon signaling pathway_Homo sapiens_hsa049220.39766885
135cAMP signaling pathway_Homo sapiens_hsa040240.39274838
136Gastric acid secretion_Homo sapiens_hsa049710.35366684
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33910759
138Tyrosine metabolism_Homo sapiens_hsa003500.32071880
139HTLV-I infection_Homo sapiens_hsa051660.31003591
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30556567
141Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30305817

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »