TCF23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix factors via the formation of a functionally inactive heterodimeric complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1opsonization (GO:0008228)7.53228571
2regulation of cardioblast differentiation (GO:0051890)7.50140489
3negative regulation of complement activation (GO:0045916)6.47809473
4detection of molecule of bacterial origin (GO:0032490)6.47484518
5maintenance of gastrointestinal epithelium (GO:0030277)6.44559153
6positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.88497763
7glomerular basement membrane development (GO:0032836)5.80939064
8behavioral response to nicotine (GO:0035095)5.42220938
9basement membrane organization (GO:0071711)5.30557940
10epithelial structure maintenance (GO:0010669)5.24685907
11negative regulation of protein activation cascade (GO:2000258)5.21656785
12positive regulation of macrophage activation (GO:0043032)5.21278472
13positive regulation of guanylate cyclase activity (GO:0031284)5.21139051
14regulation of guanylate cyclase activity (GO:0031282)5.08952943
15regulation of transforming growth factor beta2 production (GO:0032909)5.08909451
16positive regulation of hair cycle (GO:0042635)5.06970974
17positive regulation of hair follicle development (GO:0051798)5.06970974
18pathway-restricted SMAD protein phosphorylation (GO:0060389)4.90216837
19leukocyte migration involved in inflammatory response (GO:0002523)4.85103013
20cGMP biosynthetic process (GO:0006182)4.73262696
21embryonic skeletal joint morphogenesis (GO:0060272)4.62146262
22DNA deamination (GO:0045006)4.57230331
23regulation of respiratory burst (GO:0060263)4.56691009
24ovulation from ovarian follicle (GO:0001542)4.45411046
25extracellular fibril organization (GO:0043206)4.42936626
26regulation of apoptotic cell clearance (GO:2000425)4.32307120
27response to pheromone (GO:0019236)4.20167529
28lung-associated mesenchyme development (GO:0060484)4.11038885
29bundle of His cell to Purkinje myocyte communication (GO:0086069)4.03435944
30hormone catabolic process (GO:0042447)3.97594588
31lung lobe morphogenesis (GO:0060463)3.95721276
32negative regulation of humoral immune response (GO:0002921)3.92645601
33positive regulation of odontogenesis (GO:0042482)3.90232213
34cardiac muscle cell proliferation (GO:0060038)3.79025501
35response to hydroperoxide (GO:0033194)3.77917698
36tryptophan catabolic process (GO:0006569)3.75130177
37indole-containing compound catabolic process (GO:0042436)3.75130177
38indolalkylamine catabolic process (GO:0046218)3.75130177
39indolalkylamine metabolic process (GO:0006586)3.75048653
40collagen fibril organization (GO:0030199)3.73969211
41regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.73515300
42regulation of complement activation (GO:0030449)3.73088132
43platelet dense granule organization (GO:0060155)3.69079636
44detection of external biotic stimulus (GO:0098581)3.64944816
45renal filtration (GO:0097205)3.64063508
46negative regulation of telomere maintenance (GO:0032205)3.63437290
47chondrocyte proliferation (GO:0035988)3.62935618
48O-glycan processing (GO:0016266)3.62876010
49regulation of hair follicle development (GO:0051797)3.62851534
50uterus development (GO:0060065)3.62210403
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.62011101
52fibril organization (GO:0097435)3.60471792
53gland morphogenesis (GO:0022612)3.59953052
54kynurenine metabolic process (GO:0070189)3.59276136
55cellular ketone body metabolic process (GO:0046950)3.58843611
56piRNA metabolic process (GO:0034587)3.56527098
57glomerular filtration (GO:0003094)3.55587294
58L-fucose catabolic process (GO:0042355)3.53963633
59fucose catabolic process (GO:0019317)3.53963633
60L-fucose metabolic process (GO:0042354)3.53963633
61protein autoprocessing (GO:0016540)3.53277716
62mesonephros development (GO:0001823)3.52138861
63regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.48301462
64ventricular cardiac muscle cell action potential (GO:0086005)3.48237904
65water-soluble vitamin biosynthetic process (GO:0042364)3.41710921
66regulation of macrophage cytokine production (GO:0010935)3.41680946
67mannose metabolic process (GO:0006013)3.41371804
68macrophage activation involved in immune response (GO:0002281)3.40608938
69hydrogen peroxide catabolic process (GO:0042744)3.39827045
70renal system process involved in regulation of blood volume (GO:0001977)3.39735360
71regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.39421060
72glucocorticoid biosynthetic process (GO:0006704)3.38189676
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36574366
74positive regulation of chondrocyte differentiation (GO:0032332)3.36156838
75detection of light stimulus involved in sensory perception (GO:0050962)3.36003029
76detection of light stimulus involved in visual perception (GO:0050908)3.36003029
77negative regulation of metanephros development (GO:0072217)3.33987665
78apoptotic cell clearance (GO:0043277)3.33656816
79heart trabecula formation (GO:0060347)3.31003098
80regulation of protein activation cascade (GO:2000257)3.29808900
81positive regulation of epidermis development (GO:0045684)3.28221231
82tryptophan metabolic process (GO:0006568)3.28180162
83muscle cell proliferation (GO:0033002)3.27517670
84glial cell migration (GO:0008347)3.25119543
85ketone body metabolic process (GO:1902224)3.24748108
86embryonic digestive tract development (GO:0048566)3.24168972
87protein complex biogenesis (GO:0070271)3.22953598
88cardiac epithelial to mesenchymal transition (GO:0060317)3.22839459
89organ formation (GO:0048645)3.22002019
90glomerulus development (GO:0032835)3.21026333
91digestion (GO:0007586)3.20758254
92head development (GO:0060322)3.20654950
93protein heterotrimerization (GO:0070208)3.20572719
94respiratory chain complex IV assembly (GO:0008535)3.20488855
95striated muscle cell proliferation (GO:0014855)3.19827553
96behavioral response to ethanol (GO:0048149)3.19457719
97regulation of cGMP biosynthetic process (GO:0030826)3.18973749
98negative regulation of leukocyte chemotaxis (GO:0002689)3.15045124
99organ induction (GO:0001759)3.15002881
100positive regulation of cGMP biosynthetic process (GO:0030828)3.14966800
101axoneme assembly (GO:0035082)3.14386658
102negative regulation of heart growth (GO:0061117)3.12911440
103negative regulation of cardiac muscle tissue growth (GO:0055022)3.12911440
104mitochondrial respiratory chain complex I assembly (GO:0032981)3.12881492
105NADH dehydrogenase complex assembly (GO:0010257)3.12881492
106mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.12881492
107positive regulation of neutrophil migration (GO:1902624)3.12516780
108positive regulation of neutrophil chemotaxis (GO:0090023)3.12516780
109angiogenesis involved in wound healing (GO:0060055)3.10982776
110branching involved in salivary gland morphogenesis (GO:0060445)3.06612464
111preassembly of GPI anchor in ER membrane (GO:0016254)3.04070827
112positive regulation of granulocyte chemotaxis (GO:0071624)3.02547383
113protein K11-linked deubiquitination (GO:0035871)3.00362841
114peptidyl-proline hydroxylation (GO:0019511)3.00349994
115cornea development in camera-type eye (GO:0061303)2.98620868
116epithelial cilium movement (GO:0003351)2.98446947
117cellular biogenic amine catabolic process (GO:0042402)2.98281327
118amine catabolic process (GO:0009310)2.98281327
119mitochondrial respiratory chain complex assembly (GO:0033108)2.97655380
120glomerular visceral epithelial cell development (GO:0072015)2.97628781
121cellular response to gonadotropin stimulus (GO:0071371)2.97325676
122neural tube formation (GO:0001841)2.96496903
123protein-cofactor linkage (GO:0018065)2.94965501
124regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.94418288
125cGMP metabolic process (GO:0046068)2.94346542
126thyroid hormone generation (GO:0006590)2.93978800
127detection of biotic stimulus (GO:0009595)2.93847759
128positive regulation of cGMP metabolic process (GO:0030825)2.92361479
129negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92315354
130regulation of nuclear cell cycle DNA replication (GO:0033262)2.90225924
131glutathione derivative biosynthetic process (GO:1901687)2.89900184
132glutathione derivative metabolic process (GO:1901685)2.89900184
133negative regulation of digestive system process (GO:0060457)2.88190215
134response to gonadotropin (GO:0034698)2.88042586
135atrioventricular valve morphogenesis (GO:0003181)2.87053690
136cytochrome complex assembly (GO:0017004)2.86645133
137phosphatidylserine metabolic process (GO:0006658)2.85639494
138negative regulation of mast cell activation (GO:0033004)2.84884671
139retinal cone cell development (GO:0046549)2.84314307
140DNA methylation involved in gamete generation (GO:0043046)2.83870906
141indole-containing compound metabolic process (GO:0042430)2.82545678
142mannosylation (GO:0097502)2.81983882
143gamma-aminobutyric acid transport (GO:0015812)2.81121330
144kidney morphogenesis (GO:0060993)2.80779707
145neuronal action potential (GO:0019228)2.78885703
146protein polyglutamylation (GO:0018095)2.77997109
147reflex (GO:0060004)2.77562198
148rRNA catabolic process (GO:0016075)2.77526332
149cilium morphogenesis (GO:0060271)2.76992950
150nephron epithelium morphogenesis (GO:0072088)2.74363486
151nephron tubule morphogenesis (GO:0072078)2.74363486
152rhodopsin mediated signaling pathway (GO:0016056)2.73788868
153sulfation (GO:0051923)2.72213375
154regulation of rhodopsin mediated signaling pathway (GO:0022400)2.71359164
155regulation of telomere maintenance (GO:0032204)2.68447677
156regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.68364282
157cellular response to ATP (GO:0071318)2.66508595
158replication fork processing (GO:0031297)2.66447539
159positive regulation of fatty acid transport (GO:2000193)2.66393158
160regulation of glucokinase activity (GO:0033131)2.65900018
161regulation of hexokinase activity (GO:1903299)2.65900018
162adaptation of signaling pathway (GO:0023058)2.65677992
163photoreceptor cell maintenance (GO:0045494)2.65261847
164ubiquinone biosynthetic process (GO:0006744)2.64533699
165RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64514540
166tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63525781
167RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63525781
168auditory receptor cell stereocilium organization (GO:0060088)2.61715832
169DNA double-strand break processing (GO:0000729)2.60218072
170glycerophospholipid catabolic process (GO:0046475)2.60180124
171positive regulation of prostaglandin secretion (GO:0032308)2.59587208
172cytidine metabolic process (GO:0046087)2.59570136
173cytidine catabolic process (GO:0006216)2.59570136
174cytidine deamination (GO:0009972)2.59570136
175multicellular organism reproduction (GO:0032504)2.59527886
176nonmotile primary cilium assembly (GO:0035058)2.56965420
177negative regulation of DNA-dependent DNA replication (GO:2000104)2.56875477
178protein localization to cilium (GO:0061512)2.56278345
179recombinational repair (GO:0000725)2.55886200
180cAMP catabolic process (GO:0006198)2.53653032
181dopamine transport (GO:0015872)2.53276711
182regulation of cilium movement (GO:0003352)2.53205036
183double-strand break repair via homologous recombination (GO:0000724)2.52934869
184synaptic transmission, cholinergic (GO:0007271)2.51465421
185fucosylation (GO:0036065)2.51097471
186photoreceptor cell development (GO:0042461)2.50165034
187L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.48759384
188primary amino compound metabolic process (GO:1901160)2.48434821
189regulation of meiosis I (GO:0060631)2.48325175
190cilium organization (GO:0044782)2.48186149
191regulation of neurotransmitter uptake (GO:0051580)2.47210703
192S-adenosylmethionine metabolic process (GO:0046500)2.46891865
193ubiquinone metabolic process (GO:0006743)2.46624850
194pyrimidine nucleobase catabolic process (GO:0006208)2.46560544
195regulation of action potential (GO:0098900)2.45466914
196signal peptide processing (GO:0006465)2.44804306
197positive regulation of respiratory burst (GO:0060267)11.5498846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_15608294_ChIP-ChIP_MCF-7_Human4.47397668
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.10695688
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.04715712
4ZNF274_21170338_ChIP-Seq_K562_Hela4.04287488
5ESR2_21235772_ChIP-Seq_MCF-7_Human4.03806169
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.84737988
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.39656177
8VDR_22108803_ChIP-Seq_LS180_Human3.37799978
9CLOCK_20551151_ChIP-Seq_293T_Human3.22814010
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.16014965
11* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.15903425
12* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.87576362
13GBX2_23144817_ChIP-Seq_PC3_Human2.82034291
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75922526
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60173375
16IGF1R_20145208_ChIP-Seq_DFB_Human2.59718763
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.42473249
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39869439
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.36356601
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.35296773
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.35268443
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30748103
23SOX2_20726797_ChIP-Seq_SW620_Human2.24855287
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24472532
25SALL4_18804426_ChIP-ChIP_XEN_Mouse2.21799673
26PPAR_26484153_Chip-Seq_NCI-H1993_Human2.16257216
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13874495
28EWS_26573619_Chip-Seq_HEK293_Human2.08926596
29EZH2_22144423_ChIP-Seq_EOC_Human2.08379417
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07769404
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05713674
32FUS_26573619_Chip-Seq_HEK293_Human2.04389172
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03581406
34P300_19829295_ChIP-Seq_ESCs_Human2.03371051
35AR_21909140_ChIP-Seq_LNCAP_Human2.01426945
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98941782
37TAF15_26573619_Chip-Seq_HEK293_Human1.98550672
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96903685
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.95775065
40GATA4_25053715_ChIP-Seq_YYC3_Human1.94552226
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.93705183
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92026697
43ZNF263_19887448_ChIP-Seq_K562_Human1.89066091
44ER_23166858_ChIP-Seq_MCF-7_Human1.84645964
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76252863
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.73406734
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72950174
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70641915
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70641915
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.69118359
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67449684
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66231422
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64717807
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63986455
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55591813
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.55106786
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54473972
58IRF1_19129219_ChIP-ChIP_H3396_Human1.54266286
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54025685
60RACK7_27058665_Chip-Seq_MCF-7_Human1.53856597
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53587808
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53421032
63CBP_20019798_ChIP-Seq_JUKART_Human1.53421032
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52481571
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52123634
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51254214
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50911480
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.50617899
69* TP53_22573176_ChIP-Seq_HFKS_Human1.50544530
70STAT3_23295773_ChIP-Seq_U87_Human1.49752316
71TCF3_18692474_ChIP-Seq_MEFs_Mouse1.49607952
72KLF5_25053715_ChIP-Seq_YYC3_Human1.46289320
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.45017749
74AR_25329375_ChIP-Seq_VCAP_Human1.44454823
75NANOG_19829295_ChIP-Seq_ESCs_Human1.44284257
76SOX2_19829295_ChIP-Seq_ESCs_Human1.44284257
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43498502
78SMAD4_21799915_ChIP-Seq_A2780_Human1.43357572
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.43298819
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42465181
81TCF4_23295773_ChIP-Seq_U87_Human1.42002654
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41792970
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40820547
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.40588636
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40437701
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.37948680
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36900110
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36596785
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36091103
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35971810
91* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35855749
92* FOXA1_25329375_ChIP-Seq_VCAP_Human1.35855749
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.35840876
94MYC_18940864_ChIP-ChIP_HL60_Human1.35775817
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34650863
96MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.33491381
97TCF4_22108803_ChIP-Seq_LS180_Human1.33206096
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32437471
99CDX2_20551321_ChIP-Seq_CACO-2_Human1.31749357
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31724066
101EST1_17652178_ChIP-ChIP_JURKAT_Human1.30864171
102FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29788239
103CJUN_26792858_Chip-Seq_BT549_Human1.29535312
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29382565
105POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29163471
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.28977063
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28951337
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28798418
109* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28566269
110GATA6_25053715_ChIP-Seq_YYC3_Human1.28545249
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28215853
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27806358
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27806358
114EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27272304
115RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27272304
116FOXO3_23340844_ChIP-Seq_DLD1_Human1.27271174
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26716217
118GATA3_21878914_ChIP-Seq_MCF-7_Human1.25712370
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25313679
120AHR_22903824_ChIP-Seq_MCF-7_Human1.24426097
121ATF3_27146783_Chip-Seq_COLON_Human1.24003227
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23235985
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23101664
124KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22687724
125SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22372112
126* REST_21632747_ChIP-Seq_MESCs_Mouse1.21881633
127* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19794907
128CBX2_27304074_Chip-Seq_ESCs_Mouse1.19263796
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18827608
130ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18617801
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18584354
132RUNX2_22187159_ChIP-Seq_PCA_Human1.18309132
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18137606
134HOXB7_26014856_ChIP-Seq_BT474_Human1.17439091
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17026426
136SMAD4_21741376_ChIP-Seq_EPCs_Human1.16703606
137AR_20517297_ChIP-Seq_VCAP_Human1.16140319
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15496995
139IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15055816
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14790831
141FLI1_21867929_ChIP-Seq_TH2_Mouse1.14629665
142CRX_20693478_ChIP-Seq_RETINA_Mouse1.14322463
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14313307
144* GATA3_24758297_ChIP-Seq_MCF-7_Human1.14075715
145UBF1/2_26484160_Chip-Seq_HMECs_Human1.13744703
146RNF2_27304074_Chip-Seq_NSC_Mouse1.13697223
147* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13629556
148PRDM14_20953172_ChIP-Seq_ESCs_Human1.13456956
149STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12873503
150* NCOR_22424771_ChIP-Seq_293T_Human1.12866751
151ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12288592
152EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12115423
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12030258
154CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11157313
155SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10931389
156ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10927469
157ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09384509
158RUNX1_27514584_Chip-Seq_MCF-7_Human1.09116855
159NANOG_18555785_Chip-Seq_ESCs_Mouse1.09026125
160CDX2_22108803_ChIP-Seq_LS180_Human1.07903676
161EED_16625203_ChIP-ChIP_MESCs_Mouse1.07212994
162EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07104954
163SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06972555
164P53_22387025_ChIP-Seq_ESCs_Mouse1.06688520
165NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06619641
166TBX20_22080862_ChIP-Seq_HEART_Mouse1.06586098
167TBX20_22328084_ChIP-Seq_HEART_Mouse1.06586098
168* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06488693
169ISL1_27105846_Chip-Seq_CPCs_Mouse1.06134867
170LXR_22292898_ChIP-Seq_THP-1_Human1.06080013
171OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05941805
172STAT3_18555785_Chip-Seq_ESCs_Mouse1.04614374
173EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04480639
174VDR_23849224_ChIP-Seq_CD4+_Human1.03977492
175ELK1_19687146_ChIP-ChIP_HELA_Human1.03958190
176TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03603616
177TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03283771
178SMAD3_21741376_ChIP-Seq_HESCs_Human1.03168049
179RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02978254
180HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02941341
181BCAT_22108803_ChIP-Seq_LS180_Human1.02857564
182TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02788180
183P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02771769
184SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02175837
185AR_21572438_ChIP-Seq_LNCaP_Human1.01799864
186NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99314594
187KDM2B_26808549_Chip-Seq_K562_Human0.98781010
188P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98277018
189SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98101366
190FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97856782
191TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97849638
192AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96321644
193PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95468148
194ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95283310
195TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94816567
196OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94261471
197FOXH1_21741376_ChIP-Seq_EPCs_Human0.93686666
198TP53_20018659_ChIP-ChIP_R1E_Mouse0.93677582
199HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90855074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.94080215
2MP0002254_reproductive_system_inflammat4.18482082
3MP0001664_abnormal_digestion4.12600983
4MP0006054_spinal_hemorrhage3.82134543
5MP0003195_calcinosis3.01264882
6MP0008877_abnormal_DNA_methylation2.84534317
7MP0001873_stomach_inflammation2.76968835
8MP0000569_abnormal_digit_pigmentation2.70121436
9MP0001958_emphysema2.68387557
10MP0002102_abnormal_ear_morphology2.66546414
11MP0004272_abnormal_basement_membrane2.66191159
12MP0005551_abnormal_eye_electrophysiolog2.63707514
13MP0001968_abnormal_touch/_nociception2.50155797
14MP0003567_abnormal_fetal_cardiomyocyte2.29359218
15MP0006072_abnormal_retinal_apoptosis2.18555838
16MP0002876_abnormal_thyroid_physiology2.11991439
17MP0003787_abnormal_imprinting2.10470307
18MP0005275_abnormal_skin_tensile2.09606831
19MP0008872_abnormal_physiological_respon2.08143038
20MP0002638_abnormal_pupillary_reflex2.06627379
21MP0003646_muscle_fatigue2.05470386
22MP0000372_irregular_coat_pigmentation2.03375748
23MP0009046_muscle_twitch2.01158656
24MP0008004_abnormal_stomach_pH10.4581757
25MP0005645_abnormal_hypothalamus_physiol1.97459249
26MP0000470_abnormal_stomach_morphology1.97123499
27MP0005646_abnormal_pituitary_gland1.95668835
28MP0003566_abnormal_cell_adhesion1.94787419
29MP0002736_abnormal_nociception_after1.94474931
30MP0004885_abnormal_endolymph1.89654934
31MP0004142_abnormal_muscle_tone1.89147737
32MP0005253_abnormal_eye_physiology1.85034693
33MP0000681_abnormal_thyroid_gland1.84066916
34MP0006292_abnormal_olfactory_placode1.82342532
35MP0009745_abnormal_behavioral_response1.81800030
36MP0004043_abnormal_pH_regulation1.72637435
37MP0001986_abnormal_taste_sensitivity1.71965222
38MP0004484_altered_response_of1.70338371
39MP0004147_increased_porphyrin_level1.68452789
40MP0001501_abnormal_sleep_pattern1.67430046
41MP0002938_white_spotting1.67311219
42MP0000537_abnormal_urethra_morphology1.65420377
43MP0003880_abnormal_central_pattern1.65230997
44MP0002272_abnormal_nervous_system1.64484525
45MP0000604_amyloidosis1.58979626
46MP0004036_abnormal_muscle_relaxation1.58891841
47MP0001661_extended_life_span1.55811633
48MP0000427_abnormal_hair_cycle1.53421341
49MP0004883_abnormal_blood_vessel1.52696169
50MP0003011_delayed_dark_adaptation1.52203036
51MP0003279_aneurysm1.51904505
52MP0005174_abnormal_tail_pigmentation1.48162711
53MP0004084_abnormal_cardiac_muscle1.46920428
54MP0000462_abnormal_digestive_system1.45706896
55MP0006276_abnormal_autonomic_nervous1.45143303
56MP0003705_abnormal_hypodermis_morpholog1.44232947
57MP0003136_yellow_coat_color1.42052660
58MP0005084_abnormal_gallbladder_morpholo1.41787687
59MP0002653_abnormal_ependyma_morphology1.41514680
60MP0005167_abnormal_blood-brain_barrier1.41128108
61MP0008875_abnormal_xenobiotic_pharmacok1.40927265
62MP0002160_abnormal_reproductive_system1.38579741
63MP0005075_abnormal_melanosome_morpholog1.36703500
64MP0001984_abnormal_olfaction1.34299143
65MP0004133_heterotaxia1.33794378
66MP0001486_abnormal_startle_reflex1.33618444
67MP0002735_abnormal_chemical_nociception1.33601866
68MP0000631_abnormal_neuroendocrine_gland1.33096318
69MP0001485_abnormal_pinna_reflex1.30410186
70MP0003115_abnormal_respiratory_system1.29476947
71MP0002163_abnormal_gland_morphology1.27998233
72MP0000767_abnormal_smooth_muscle1.25817091
73MP0004742_abnormal_vestibular_system1.25711199
74MP0002733_abnormal_thermal_nociception1.25123712
75MP0010234_abnormal_vibrissa_follicle1.24116515
76MP0004145_abnormal_muscle_electrophysio1.23981951
77MP0000751_myopathy1.23890735
78MP0000538_abnormal_urinary_bladder1.23229607
79MP0009384_cardiac_valve_regurgitation1.22898042
80MP0005165_increased_susceptibility_to1.21734381
81MP0003283_abnormal_digestive_organ1.19032000
82MP0001970_abnormal_pain_threshold1.18030826
83MP0002572_abnormal_emotion/affect_behav1.17591424
84MP0005381_digestive/alimentary_phenotyp1.17031104
85MP0002557_abnormal_social/conspecific_i1.16099680
86MP0005503_abnormal_tendon_morphology1.15384434
87MP0005164_abnormal_response_to1.15276019
88MP0005636_abnormal_mineral_homeostasis1.15130761
89MP0000013_abnormal_adipose_tissue1.14644742
90MP0001919_abnormal_reproductive_system1.14098825
91MP0003718_maternal_effect1.12655748
92MP0001529_abnormal_vocalization1.12331873
93MP0003329_amyloid_beta_deposits1.11665326
94MP0002064_seizures1.09745163
95MP0005379_endocrine/exocrine_gland_phen1.09591440
96MP0002928_abnormal_bile_duct1.07743622
97MP0003941_abnormal_skin_development1.07235356
98MP0005670_abnormal_white_adipose1.06925903
99MP0005410_abnormal_fertilization1.06812344
100MP0001849_ear_inflammation1.06782503
101MP0001663_abnormal_digestive_system1.06459284
102MP0005389_reproductive_system_phenotype1.06135377
103MP0002067_abnormal_sensory_capabilities1.05319604
104MP0001905_abnormal_dopamine_level1.04944827
105MP0008058_abnormal_DNA_repair1.04773737
106MP0005386_behavior/neurological_phenoty1.02545444
107MP0004924_abnormal_behavior1.02545444
108MP0001765_abnormal_ion_homeostasis1.02161246
109MP0005195_abnormal_posterior_eye1.01904120
110MP0002095_abnormal_skin_pigmentation1.00330619
111MP0000477_abnormal_intestine_morphology0.97096416
112MP0002693_abnormal_pancreas_physiology0.94983213
113MP0001879_abnormal_lymphatic_vessel0.94804087
114MP0001756_abnormal_urination0.93100879
115MP0002751_abnormal_autonomic_nervous0.92723909
116MP0010368_abnormal_lymphatic_system0.92533586
117MP0001727_abnormal_embryo_implantation0.92196981
118MP0008775_abnormal_heart_ventricle0.91463634
119MP0005166_decreased_susceptibility_to0.90850491
120MP0002277_abnormal_respiratory_mucosa0.90845674
121MP0008995_early_reproductive_senescence0.90818451
122MP0002282_abnormal_trachea_morphology0.90529204
123MP0003448_altered_tumor_morphology0.90477538
124MP0003315_abnormal_perineum_morphology0.89718506
125MP0000858_altered_metastatic_potential0.88764935
126MP0002909_abnormal_adrenal_gland0.88254650
127MP0002060_abnormal_skin_morphology0.88182020
128MP0004215_abnormal_myocardial_fiber0.88032396
129MP0001881_abnormal_mammary_gland0.87949991
130MP0005332_abnormal_amino_acid0.87627098
131MP0001324_abnormal_eye_pigmentation0.87612559
132MP0003121_genomic_imprinting0.87429617
133MP0003635_abnormal_synaptic_transmissio0.87352831
134MP0000343_altered_response_to0.86006791
135MP0002063_abnormal_learning/memory/cond0.86000450
136MP0000627_abnormal_mammary_gland0.85993265
137MP0000249_abnormal_blood_vessel0.85716998
138MP0010386_abnormal_urinary_bladder0.85707677
139MP0005623_abnormal_meninges_morphology0.85093520
140MP0003693_abnormal_embryo_hatching0.85067833
141MP0000383_abnormal_hair_follicle0.84688606
142MP0001764_abnormal_homeostasis0.84621839
143MP0003698_abnormal_male_reproductive0.83421779
144MP0002734_abnormal_mechanical_nocicepti0.83128938
145MP0003878_abnormal_ear_physiology0.82709951
146MP0005377_hearing/vestibular/ear_phenot0.82709951
147MP0003191_abnormal_cellular_cholesterol0.82702585
148MP0003252_abnormal_bile_duct0.82595967
149MP0002752_abnormal_somatic_nervous0.82484975
150MP0005058_abnormal_lysosome_morphology0.82068875
151MP0001502_abnormal_circadian_rhythm0.80966359
152MP0000534_abnormal_ureter_morphology0.80879800
153MP0002229_neurodegeneration0.79741774
154MP0005508_abnormal_skeleton_morphology0.78211230
155MP0000015_abnormal_ear_pigmentation0.78000550
156MP0003119_abnormal_digestive_system0.77142911
157MP0003828_pulmonary_edema0.76871369
158MP0003137_abnormal_impulse_conducting0.76407632
159MP0009333_abnormal_splenocyte_physiolog0.76372640
160MP0001929_abnormal_gametogenesis0.76280289
161MP0003936_abnormal_reproductive_system0.75914827
162MP0000750_abnormal_muscle_regeneration0.73900805
163MP0009250_abnormal_appendicular_skeleto0.73807217
164MP0001542_abnormal_bone_strength0.73416795
165MP0003045_fibrosis0.72182439
166MP0004264_abnormal_extraembryonic_tissu0.71970493
167MP0001963_abnormal_hearing_physiology0.71830993
168MP0004019_abnormal_vitamin_homeostasis0.70480271
169MP0002837_dystrophic_cardiac_calcinosis0.70215026
170MP0003385_abnormal_body_wall0.68971420
171MP0000230_abnormal_systemic_arterial0.67280267
172MP0002234_abnormal_pharynx_morphology0.66995461
173MP0005330_cardiomyopathy0.66869843
174MP0000566_synostosis0.66568053
175MP0009278_abnormal_bone_marrow0.64807285
176MP0009053_abnormal_anal_canal0.64794827
177MP0001614_abnormal_blood_vessel0.64066433
178MP0009643_abnormal_urine_homeostasis0.62301095
179MP0006138_congestive_heart_failure0.59477505
180MP0005385_cardiovascular_system_phenoty0.59146211
181MP0001544_abnormal_cardiovascular_syste0.59146211
182MP0003938_abnormal_ear_development0.58683327
183MP0000049_abnormal_middle_ear0.58656761
184MP0001666_abnormal_nutrient_absorption0.58299546
185MP0003935_abnormal_craniofacial_develop0.58172345
186MP0003950_abnormal_plasma_membrane0.58129310
187MP0002136_abnormal_kidney_physiology0.57691176
188MP0002138_abnormal_hepatobiliary_system0.56948493

Predicted human phenotypes

RankGene SetZ-score
1Aortic dissection (HP:0002647)7.16184898
2Arterial tortuosity (HP:0005116)6.44448222
3Spondylolisthesis (HP:0003302)5.94111207
4Vascular tortuosity (HP:0004948)5.73509729
5Premature rupture of membranes (HP:0001788)5.65076843
6Aortic aneurysm (HP:0004942)5.50467268
7Right ventricular cardiomyopathy (HP:0011663)4.93967803
8Ankle contracture (HP:0006466)4.92573289
9Cerebral aneurysm (HP:0004944)4.82436885
10Pancreatic cysts (HP:0001737)4.66966810
11Ulnar bowing (HP:0003031)4.40346791
12Abnormality of midbrain morphology (HP:0002418)4.26204577
13Molar tooth sign on MRI (HP:0002419)4.26204577
14Mesangial abnormality (HP:0001966)4.21273082
15Pancreatic fibrosis (HP:0100732)4.17090217
16True hermaphroditism (HP:0010459)3.99046023
17Congenital stationary night blindness (HP:0007642)3.94975596
18Nephronophthisis (HP:0000090)3.83460130
19Osteolytic defects of the hand bones (HP:0009699)3.73695727
20Osteolytic defects of the phalanges of the hand (HP:0009771)3.73695727
21Abnormality of the renal cortex (HP:0011035)3.46597855
22Type II lissencephaly (HP:0007260)3.42373222
23Malnutrition (HP:0004395)3.40065599
24Abnormality of the renal medulla (HP:0100957)3.39489202
25Broad metatarsal (HP:0001783)3.36778679
26Systemic lupus erythematosus (HP:0002725)3.35716535
27Radial bowing (HP:0002986)3.33477419
28Neoplasm of the heart (HP:0100544)3.15343753
29Follicular hyperkeratosis (HP:0007502)3.15206596
30Soft skin (HP:0000977)3.10704185
31Purpura (HP:0000979)3.06921007
32Hyperventilation (HP:0002883)3.03801291
33Absent frontal sinuses (HP:0002688)3.00524761
34Tubular atrophy (HP:0000092)2.97467008
35Aplastic anemia (HP:0001915)2.94060273
36Bicuspid aortic valve (HP:0001647)2.90490348
37Polydipsia (HP:0001959)2.88544741
38Abnormal drinking behavior (HP:0030082)2.88544741
39Abnormality of abdominal situs (HP:0011620)2.86860533
40Abdominal situs inversus (HP:0003363)2.86860533
41Petechiae (HP:0000967)2.86410917
42Pendular nystagmus (HP:0012043)2.86012728
43Delayed closure of the anterior fontanelle (HP:0001476)2.85269239
44Abolished electroretinogram (ERG) (HP:0000550)2.85184332
45Short hallux (HP:0010109)2.84675242
46Medial flaring of the eyebrow (HP:0010747)2.84628294
47Attenuation of retinal blood vessels (HP:0007843)2.84036296
48Ventricular fibrillation (HP:0001663)2.83915570
49Cystic liver disease (HP:0006706)2.82515047
50Abnormal rod and cone electroretinograms (HP:0008323)2.79843855
51Chronic hepatic failure (HP:0100626)2.75971023
52Type 1 muscle fiber predominance (HP:0003803)2.71883474
53Bowing of the arm (HP:0006488)2.70951040
54Bowed forearm bones (HP:0003956)2.70951040
55Large for gestational age (HP:0001520)2.70945997
56Aplasia/Hypoplasia of the hallux (HP:0008362)2.65347406
57Fragile skin (HP:0001030)2.62357912
58Wrist flexion contracture (HP:0001239)2.62215967
59Mitral valve prolapse (HP:0001634)2.61802348
60Increased corneal curvature (HP:0100692)2.61707522
61Keratoconus (HP:0000563)2.61707522
62Inability to walk (HP:0002540)2.58289552
63Focal segmental glomerulosclerosis (HP:0000097)2.53464677
64Decreased circulating renin level (HP:0003351)2.53045931
65Cervical subluxation (HP:0003308)2.51896603
66Progressive inability to walk (HP:0002505)2.51873959
67Syncope (HP:0001279)2.50455725
68Glomerulonephritis (HP:0000099)2.49923033
69Protrusio acetabuli (HP:0003179)2.46923862
70Aneurysm (HP:0002617)2.46901608
71Cerebellar dysplasia (HP:0007033)2.46283425
72Pulmonary artery stenosis (HP:0004415)2.45931043
73Testicular atrophy (HP:0000029)2.45381576
74Gaze-evoked nystagmus (HP:0000640)2.44623434
75Facial diplegia (HP:0001349)2.44130009
76Abnormal delivery (HP:0001787)2.41380395
77Hypothermia (HP:0002045)2.40502040
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38979250
79Abnormality of alanine metabolism (HP:0010916)2.38979250
80Hyperalaninemia (HP:0003348)2.38979250
81Renal cortical cysts (HP:0000803)2.38388661
82Absent rod-and cone-mediated responses on ERG (HP:0007688)2.38084266
83Bile duct proliferation (HP:0001408)2.35592667
84Abnormal biliary tract physiology (HP:0012439)2.35592667
85Sclerocornea (HP:0000647)2.34967078
86Aortic regurgitation (HP:0001659)2.32322269
87Polyuria (HP:0000103)2.27658480
88Lissencephaly (HP:0001339)2.27573184
89Tarsal synostosis (HP:0008368)2.27443321
90Gastrointestinal dysmotility (HP:0002579)2.26835891
91Nephritis (HP:0000123)2.25626084
92Furrowed tongue (HP:0000221)2.25449808
93Persistence of primary teeth (HP:0006335)2.24815698
94Asymmetric septal hypertrophy (HP:0001670)2.23351326
95Acute necrotizing encephalopathy (HP:0006965)2.22313806
96Rectal prolapse (HP:0002035)2.22139663
97Decreased central vision (HP:0007663)2.21878023
98Abnormal cartilage morphology (HP:0002763)2.21271282
99Aplasia/Hypoplasia of the tongue (HP:0010295)2.21044357
100Congenital, generalized hypertrichosis (HP:0004540)2.21009562
101Increased CSF lactate (HP:0002490)2.20783896
102Synostosis involving bones of the lower limbs (HP:0009138)2.19725069
103Synostosis involving bones of the feet (HP:0009140)2.19725069
104Mitochondrial inheritance (HP:0001427)2.19171186
105Hemiplegia (HP:0002301)2.17753428
106Congenital hepatic fibrosis (HP:0002612)2.17684175
107Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16428712
108Abnormality of the pons (HP:0007361)2.14907520
109Mildly elevated creatine phosphokinase (HP:0008180)2.14607695
110Progressive macrocephaly (HP:0004481)2.13327649
111Ketoacidosis (HP:0001993)2.13286203
112Polycythemia (HP:0001901)2.12738327
113Increased variability in muscle fiber diameter (HP:0003557)2.12428675
114Broad-based gait (HP:0002136)2.11367109
115Gait imbalance (HP:0002141)2.10366802
116Male pseudohermaphroditism (HP:0000037)2.09732291
117Testicular neoplasm (HP:0010788)2.09606617
118Stomach cancer (HP:0012126)2.09463690
119Shallow orbits (HP:0000586)2.08785510
120Aplasia/Hypoplasia of the tibia (HP:0005772)2.07960481
121Concave nail (HP:0001598)2.07712139
122Delayed cranial suture closure (HP:0000270)2.06654361
123Anencephaly (HP:0002323)2.06034200
124Hypoplasia of the pons (HP:0012110)2.05883684
125Blue sclerae (HP:0000592)2.05536428
126Hypoplastic left heart (HP:0004383)2.05432612
127Congenital primary aphakia (HP:0007707)2.03319626
128Knee flexion contracture (HP:0006380)2.02628424
129Biliary tract neoplasm (HP:0100574)2.01149401
130Spinal rigidity (HP:0003306)2.00422425
131Glomerulosclerosis (HP:0000096)1.99061418
132Acute encephalopathy (HP:0006846)1.98763289
133Dilatation of the ascending aorta (HP:0005111)1.98307332
134Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.97770748
135Hyporeflexia of lower limbs (HP:0002600)1.97397525
136Severe muscular hypotonia (HP:0006829)1.95809013
137Hemiparesis (HP:0001269)1.95709478
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.95212635
139Absent/shortened dynein arms (HP:0200106)1.95212635
140Chorioretinal atrophy (HP:0000533)1.95127263
1413-Methylglutaconic aciduria (HP:0003535)1.93654482
142Muscle fiber splitting (HP:0003555)1.93363136
143Nephrogenic diabetes insipidus (HP:0009806)1.91011788
144Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.90861982
145Fair hair (HP:0002286)1.90837244
146Wormian bones (HP:0002645)1.90199363
147Mucopolysacchariduria (HP:0008155)1.89968618
148Urinary glycosaminoglycan excretion (HP:0003541)1.89968618
149Progressive cerebellar ataxia (HP:0002073)1.89662558
150Atrophic scars (HP:0001075)1.89335910
151Optic disc pallor (HP:0000543)1.89052456
152Dysostosis multiplex (HP:0000943)1.88832664
153Methylmalonic acidemia (HP:0002912)1.88749917
154Postaxial foot polydactyly (HP:0001830)1.86829214
155Elbow flexion contracture (HP:0002987)1.86433938
156Focal motor seizures (HP:0011153)1.86426772
157Ketosis (HP:0001946)1.85667218
158Hepatocellular necrosis (HP:0001404)1.85566762
159Intestinal atresia (HP:0011100)1.85376875
160Abnormal mitochondria in muscle tissue (HP:0008316)1.85319301
161Increased connective tissue (HP:0009025)1.84367660
162Hypomagnesemia (HP:0002917)1.84311873
163Methylmalonic aciduria (HP:0012120)1.84229096
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.83487746
165Hypoplasia of the fovea (HP:0007750)1.83487746
166Germ cell neoplasia (HP:0100728)1.83223717
167Gonadal dysgenesis (HP:0000133)1.82737260
168Atrioventricular block (HP:0001678)1.82396251
169Thyroid-stimulating hormone excess (HP:0002925)1.82106053
170Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81460111
171Absent speech (HP:0001344)1.81457265
172Redundant skin (HP:0001582)1.81446537
173Optic nerve hypoplasia (HP:0000609)1.80995876
174Aplasia/hypoplasia of the uterus (HP:0008684)1.80394532
175Arachnodactyly (HP:0001166)1.80391413
176Febrile seizures (HP:0002373)1.78814409
177Tachypnea (HP:0002789)1.78615694
178Abnormal urine output (HP:0012590)1.77870218
179Stomatitis (HP:0010280)1.77736141
180Hyperglycinuria (HP:0003108)1.76963475
181Wide anterior fontanel (HP:0000260)1.76129866
182Hepatic necrosis (HP:0002605)1.75687368
183Protruding tongue (HP:0010808)1.75458413
184Ventricular arrhythmia (HP:0004308)1.74755905
185Aplasia/Hypoplasia of the uvula (HP:0010293)1.74503891
186Ventricular tachycardia (HP:0004756)1.74457308
187Bony spicule pigmentary retinopathy (HP:0007737)1.74225358
188Abnormal biliary tract morphology (HP:0012440)1.73761118
189Pachygyria (HP:0001302)1.73403833
190Abnormality of skeletal muscle fiber size (HP:0012084)1.73127347
191Abnormality of the vasculature of the conjunctiva (HP:0008054)1.72824637
192Abnormality of macular pigmentation (HP:0008002)1.72079206
193Trismus (HP:0000211)1.72018108
194Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71873558
195Abnormality of polysaccharide metabolism (HP:0011012)1.71873558
196Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71873558
197Genital tract atresia (HP:0001827)1.71594492
198Hyperextensible skin (HP:0000974)1.69487343
199Spontaneous abortion (HP:0005268)1.69021385

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB46.04809157
2FRK5.60868479
3MYLK5.24373245
4TGFBR24.46129283
5TTN4.25236508
6MST1R3.72408301
7ADRBK23.68552461
8BMPR1B3.11595612
9DMPK2.86626041
10MAP4K22.73856036
11ZAK2.70685784
12ACVR1B2.64046021
13TRIB32.59001219
14GRK12.45523643
15WNK32.42932167
16TLK12.39430049
17TAOK32.30800814
18WNK42.29239952
19PINK12.21847882
20EPHB22.17799934
21FER2.07439637
22PIK3CG2.05360820
23MET2.03669656
24MST41.93961630
25PDGFRA1.90371240
26MAPK131.85004328
27PAK21.84751010
28LMTK21.83613411
29AKT31.78081238
30MAPKAPK31.73221324
31OXSR11.72369807
32CASK1.71655328
33INSRR1.71583956
34STK391.69283949
35TXK1.67124529
36ERN11.64788366
37PAK41.64773513
38LATS11.52900709
39TIE11.50852949
40NUAK11.48770219
41DDR21.47071015
42PTK61.44446807
43DAPK21.44345829
44MAP3K41.43510824
45TRIM281.43051800
46MKNK21.30632631
47STK38L1.30225738
48NME11.28881084
49PDK21.28146254
50TNIK1.25328079
51PTK2B1.24836006
52ADRBK11.23605210
53STK31.12142714
54LRRK21.12136757
55MAP2K21.10564809
56IRAK31.09958229
57TGFBR11.09916361
58PKN21.08580206
59PRKCE1.08445742
60PTK21.02925761
61MARK11.00267593
62DYRK20.99118498
63NME20.97889794
64PLK20.96230527
65PRKCG0.96068808
66VRK10.95804903
67KDR0.94413587
68PAK10.92324490
69PIK3CA0.91614571
70NEK90.91418644
71NEK20.86146482
72MAP2K60.85963557
73TYRO30.85793914
74CAMKK20.85735595
75WEE10.84083612
76CSNK1G10.83488851
77NTRK30.83060046
78TTK0.82948540
79MAP2K70.81985379
80IRAK10.81940175
81PHKG10.81541866
82PHKG20.81541866
83EPHB10.81279544
84BCKDK0.80933907
85STK380.80561738
86EIF2AK30.79302741
87BCR0.78950738
88CDC42BPA0.76287564
89LATS20.72886949
90CSNK1G30.72048634
91PAK30.71637172
92MUSK0.71594666
93RIPK10.71180094
94BUB10.71024582
95RPS6KB20.70585471
96FGFR20.70564479
97TEC0.70353625
98ILK0.69136578
99PDK40.68972065
100PDK30.68972065
101ROCK10.68948223
102PLK30.68436472
103PRKG20.68005187
104TESK10.67689377
105PRKCI0.66794976
106MAP2K10.65221010
107IKBKB0.64891606
108PNCK0.63554969
109PLK40.62661849
110PDPK10.62101233
111KIT0.61946754
112NEK10.61578643
113BMX0.61109802
114PRKCQ0.60704553
115PDGFRB0.59245681
116MKNK10.58983164
117MAP3K30.56395656
118ERBB30.55761168
119NLK0.55513389
120EPHA20.55501189
121SRC0.53625807
122CDK70.53617488
123ROCK20.53482623
124DAPK30.52377666
125CAMK2A0.51688146
126VRK20.50416546
127BRSK20.50116279
128PKN10.49635361
129MAPKAPK50.47886038
130MAP3K80.47615869
131RPS6KA50.47137979
132TNK20.46080681
133GSK3A0.44623308
134MAPK150.44471496
135CSNK1A10.44459468
136LIMK10.44275792
137EPHA40.44215006
138PRKACA0.43024250
139STK110.42182055
140ITK0.42064442
141GRK70.40549771
142CDK40.39772597
143FYN0.38400974
144MAP3K100.38340585
145AKT20.36369364
146NTRK20.36100991
147CSNK1D0.35677432
148MTOR0.35467059
149SRPK10.35127463
150STK100.33653249
151PRKACB0.33628189
152GRK50.33597202
153MARK30.32923376
154PRKCA0.32833766
155ZAP700.32054809
156PRKCZ0.31879321
157CSNK1A1L0.31127796
158FGFR10.31127515
159NTRK10.30916979
160PRKG10.30665548
161IGF1R0.30620810
162RPS6KA20.29667526
163OBSCN0.28651942
164CHUK0.28626673
165FLT30.28591854
166PRKAA10.28343007
167ABL10.27306434
168CAMK10.25430143
169PRKAA20.25288208
170CAMK2G0.25092804
171AURKB0.24778586
172BRAF0.24357238
173EEF2K0.24055510
174ALK0.23983168
175MAP2K30.23713282
176PRKD10.20907057
177CSNK1E0.20674691
178RPS6KL10.18743584
179RPS6KC10.18743584
180MAPKAPK20.17322756
181CSNK1G20.17140863

Predicted pathways (KEGG)

RankGene SetZ-score
1Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005124.47475151
2Glutathione metabolism_Homo sapiens_hsa004803.77631506
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.26015049
4Phototransduction_Homo sapiens_hsa047443.06991953
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.96541677
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.86520931
7ECM-receptor interaction_Homo sapiens_hsa045122.66501830
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.41345264
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40860348
10Butanoate metabolism_Homo sapiens_hsa006502.36303011
11Caffeine metabolism_Homo sapiens_hsa002322.33261597
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31686442
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.24920583
14Other glycan degradation_Homo sapiens_hsa005112.24621270
15Gastric acid secretion_Homo sapiens_hsa049712.20852020
16Selenocompound metabolism_Homo sapiens_hsa004502.19993643
17Vitamin B6 metabolism_Homo sapiens_hsa007502.15604684
18Oxidative phosphorylation_Homo sapiens_hsa001902.12518725
19Vitamin digestion and absorption_Homo sapiens_hsa049772.02317194
20Protein export_Homo sapiens_hsa030601.98285353
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98112820
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.97170419
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.94158352
24Mineral absorption_Homo sapiens_hsa049781.92100242
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89161979
26Lysosome_Homo sapiens_hsa041421.88977712
27Chemical carcinogenesis_Homo sapiens_hsa052041.87830568
28Arachidonic acid metabolism_Homo sapiens_hsa005901.87779019
29Amoebiasis_Homo sapiens_hsa051461.86602541
30Ether lipid metabolism_Homo sapiens_hsa005651.83347240
31Nicotine addiction_Homo sapiens_hsa050331.82597346
32TGF-beta signaling pathway_Homo sapiens_hsa043501.81734766
33Tryptophan metabolism_Homo sapiens_hsa003801.80725125
34Homologous recombination_Homo sapiens_hsa034401.80626393
35Nitrogen metabolism_Homo sapiens_hsa009101.79827206
36Focal adhesion_Homo sapiens_hsa045101.78966170
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.73496968
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.71185576
39RNA polymerase_Homo sapiens_hsa030201.67972931
40Fanconi anemia pathway_Homo sapiens_hsa034601.64763117
41Dilated cardiomyopathy_Homo sapiens_hsa054141.64175618
42Basal transcription factors_Homo sapiens_hsa030221.59426773
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55808848
44Parkinsons disease_Homo sapiens_hsa050121.55217550
45Complement and coagulation cascades_Homo sapiens_hsa046101.47731118
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42333943
47Propanoate metabolism_Homo sapiens_hsa006401.42204406
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38686951
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37766669
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34183667
51Thyroid hormone synthesis_Homo sapiens_hsa049181.33553662
52Olfactory transduction_Homo sapiens_hsa047401.31434658
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.31204156
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31158877
55Fat digestion and absorption_Homo sapiens_hsa049751.30619868
56Sulfur metabolism_Homo sapiens_hsa009201.30062817
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29542786
58Pentose phosphate pathway_Homo sapiens_hsa000301.28897392
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.23352934
60Sphingolipid metabolism_Homo sapiens_hsa006001.22841932
61Morphine addiction_Homo sapiens_hsa050321.21375112
62Peroxisome_Homo sapiens_hsa041461.21275163
63RNA degradation_Homo sapiens_hsa030181.18791113
64Staphylococcus aureus infection_Homo sapiens_hsa051501.18210462
65Tight junction_Homo sapiens_hsa045301.17493196
66One carbon pool by folate_Homo sapiens_hsa006701.16823810
67Taste transduction_Homo sapiens_hsa047421.16185011
68Proteoglycans in cancer_Homo sapiens_hsa052051.15258422
69Retinol metabolism_Homo sapiens_hsa008301.10720907
70Small cell lung cancer_Homo sapiens_hsa052221.10185258
71ABC transporters_Homo sapiens_hsa020101.10109495
72Collecting duct acid secretion_Homo sapiens_hsa049661.07865161
73Primary bile acid biosynthesis_Homo sapiens_hsa001201.03044769
74Adherens junction_Homo sapiens_hsa045200.99948956
75Protein digestion and absorption_Homo sapiens_hsa049740.97257890
76Insulin secretion_Homo sapiens_hsa049110.97246165
77Huntingtons disease_Homo sapiens_hsa050160.94534790
78Hippo signaling pathway_Homo sapiens_hsa043900.93529797
79Alzheimers disease_Homo sapiens_hsa050100.91560874
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89822123
81Rheumatoid arthritis_Homo sapiens_hsa053230.88905405
82Asthma_Homo sapiens_hsa053100.88147319
83Primary immunodeficiency_Homo sapiens_hsa053400.87695545
84PPAR signaling pathway_Homo sapiens_hsa033200.87606487
85Proteasome_Homo sapiens_hsa030500.87407407
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84565358
87Cardiac muscle contraction_Homo sapiens_hsa042600.84397926
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83506798
89Type I diabetes mellitus_Homo sapiens_hsa049400.82935289
90GABAergic synapse_Homo sapiens_hsa047270.81273791
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80523095
92Ovarian steroidogenesis_Homo sapiens_hsa049130.80116720
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79950743
94Circadian entrainment_Homo sapiens_hsa047130.79866407
95Serotonergic synapse_Homo sapiens_hsa047260.79223479
96Glutamatergic synapse_Homo sapiens_hsa047240.77577137
97Glycerolipid metabolism_Homo sapiens_hsa005610.74580419
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74020953
99Purine metabolism_Homo sapiens_hsa002300.73751090
100Arginine and proline metabolism_Homo sapiens_hsa003300.72796399
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71839295
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70912655
103Bile secretion_Homo sapiens_hsa049760.69708263
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68860207
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68799496
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68380340
107Non-homologous end-joining_Homo sapiens_hsa034500.68127525
108Salivary secretion_Homo sapiens_hsa049700.68122575
109Renal cell carcinoma_Homo sapiens_hsa052110.68078426
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65809458
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65750662
112Dorso-ventral axis formation_Homo sapiens_hsa043200.64522184
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.64204338
114Metabolic pathways_Homo sapiens_hsa011000.63596414
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.62049079
116Tuberculosis_Homo sapiens_hsa051520.60736778
117Hematopoietic cell lineage_Homo sapiens_hsa046400.57311584
118Autoimmune thyroid disease_Homo sapiens_hsa053200.56971670
119Salmonella infection_Homo sapiens_hsa051320.56896431
120Phagosome_Homo sapiens_hsa041450.56436876
121Allograft rejection_Homo sapiens_hsa053300.56330069
122Viral myocarditis_Homo sapiens_hsa054160.55795924
123Linoleic acid metabolism_Homo sapiens_hsa005910.55672808
124Graft-versus-host disease_Homo sapiens_hsa053320.55489220
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55197076
126Calcium signaling pathway_Homo sapiens_hsa040200.54438266
127Pyrimidine metabolism_Homo sapiens_hsa002400.53648876
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52283957
129Toxoplasmosis_Homo sapiens_hsa051450.51795731
130beta-Alanine metabolism_Homo sapiens_hsa004100.50555517
131Fructose and mannose metabolism_Homo sapiens_hsa000510.50171491
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48978458
133Chronic myeloid leukemia_Homo sapiens_hsa052200.48672487
134Pertussis_Homo sapiens_hsa051330.48269630
135Renin-angiotensin system_Homo sapiens_hsa046140.48079700
136Galactose metabolism_Homo sapiens_hsa000520.45940396
137Rap1 signaling pathway_Homo sapiens_hsa040150.45164727
138Pathways in cancer_Homo sapiens_hsa052000.44603317
139Steroid biosynthesis_Homo sapiens_hsa001000.42381298
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42325461
141Ras signaling pathway_Homo sapiens_hsa040140.42057157
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40567393
143Osteoclast differentiation_Homo sapiens_hsa043800.40366805
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.38690222
145Pancreatic secretion_Homo sapiens_hsa049720.38271992
146Regulation of autophagy_Homo sapiens_hsa041400.37742980
147Dopaminergic synapse_Homo sapiens_hsa047280.36645697
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36462012
149Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36277411
150Colorectal cancer_Homo sapiens_hsa052100.36071931
151Arginine biosynthesis_Homo sapiens_hsa002200.32403019
152Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32292485
153Circadian rhythm_Homo sapiens_hsa047100.32102304
154FoxO signaling pathway_Homo sapiens_hsa040680.32027023
155Carbon metabolism_Homo sapiens_hsa012000.30949562
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30947427
157Pancreatic cancer_Homo sapiens_hsa052120.30719376
158Fatty acid metabolism_Homo sapiens_hsa012120.30627591
159Histidine metabolism_Homo sapiens_hsa003400.29380148
160Fatty acid degradation_Homo sapiens_hsa000710.28454011
161MicroRNAs in cancer_Homo sapiens_hsa052060.27277776
162Thyroid cancer_Homo sapiens_hsa052160.25413400
163Renin secretion_Homo sapiens_hsa049240.25311101
164Folate biosynthesis_Homo sapiens_hsa007900.23749119
165Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21162151
166Platelet activation_Homo sapiens_hsa046110.20435423
167Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20227851
168Axon guidance_Homo sapiens_hsa043600.19737339
169Apoptosis_Homo sapiens_hsa042100.19476204

Most similar genes based on co-expression Upload to Enrichr

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