TCF25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.09969678
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.04463939
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.50660760
4locomotory exploration behavior (GO:0035641)5.45747539
5synaptic vesicle exocytosis (GO:0016079)5.37812059
6glutamate secretion (GO:0014047)5.28177462
7regulation of synaptic vesicle exocytosis (GO:2000300)5.13614346
8mannose metabolic process (GO:0006013)4.85883082
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.85250157
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.78228240
11vocalization behavior (GO:0071625)4.78098741
12neurotransmitter secretion (GO:0007269)4.55220185
13neuronal action potential propagation (GO:0019227)4.53059197
14regulation of synaptic vesicle transport (GO:1902803)4.51166727
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.40184933
16regulation of glutamate receptor signaling pathway (GO:1900449)4.29018140
17layer formation in cerebral cortex (GO:0021819)4.24347783
18exploration behavior (GO:0035640)4.05788779
19negative regulation of erythrocyte differentiation (GO:0045647)4.03480931
20protein localization to synapse (GO:0035418)4.02641113
21regulation of neuronal synaptic plasticity (GO:0048168)4.01957009
22activation of protein kinase A activity (GO:0034199)4.01811059
23regulation of synapse structural plasticity (GO:0051823)3.94131591
24sodium ion export (GO:0071436)3.93460303
25cellular potassium ion homeostasis (GO:0030007)3.93315650
26proline transport (GO:0015824)3.93207225
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.84835731
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.83652131
29neuron cell-cell adhesion (GO:0007158)3.71470640
30gamma-aminobutyric acid transport (GO:0015812)3.70788474
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.66819989
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.64513872
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.57949940
34neurotransmitter transport (GO:0006836)3.56955834
35synaptic transmission, glutamatergic (GO:0035249)3.51918972
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51753966
37long-term memory (GO:0007616)3.49579710
38negative regulation of cell killing (GO:0031342)3.49097247
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49097247
40neuromuscular process controlling posture (GO:0050884)3.48623734
41cerebellar Purkinje cell differentiation (GO:0021702)3.48362205
42positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.47192605
43cell communication by electrical coupling (GO:0010644)3.45820769
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38150431
45neuron-neuron synaptic transmission (GO:0007270)3.37216713
46dendritic spine morphogenesis (GO:0060997)3.36538807
47positive regulation of histone deacetylation (GO:0031065)3.36368495
48regulation of neurotransmitter levels (GO:0001505)3.34870445
49glutamate receptor signaling pathway (GO:0007215)3.33856557
50regulation of ARF protein signal transduction (GO:0032012)3.31203182
51glycine transport (GO:0015816)3.27396984
52vesicle transport along microtubule (GO:0047496)3.26367669
53positive regulation of synapse maturation (GO:0090129)3.26046943
54negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.25800097
55neuromuscular process controlling balance (GO:0050885)3.25650119
56cerebellar Purkinje cell layer development (GO:0021680)3.22073248
57synaptic vesicle endocytosis (GO:0048488)3.21589156
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21465995
59positive regulation of membrane potential (GO:0045838)3.21317124
60regulation of synaptic plasticity (GO:0048167)3.19735442
61regulation of neurotransmitter secretion (GO:0046928)3.18737896
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15008169
63antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13026264
64regulation of ARF GTPase activity (GO:0032312)3.12620188
65regulation of vesicle fusion (GO:0031338)3.11865954
66antigen processing and presentation of endogenous antigen (GO:0019883)3.10712933
67negative regulation of microtubule polymerization (GO:0031115)3.10172737
68regulation of postsynaptic membrane potential (GO:0060078)3.09166402
69dendrite morphogenesis (GO:0048813)3.08359903
70neuron recognition (GO:0008038)3.08081657
71positive regulation of CREB transcription factor activity (GO:0032793)3.07730708
72neurotransmitter-gated ion channel clustering (GO:0072578)3.07507666
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.04553388
74positive regulation of gamma-delta T cell activation (GO:0046645)3.02185520
75long-term synaptic potentiation (GO:0060291)3.01968054
76positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01793067
77innervation (GO:0060384)3.01031063
78G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00669599
79mating behavior (GO:0007617)3.00362674
80membrane depolarization during action potential (GO:0086010)2.99078709
81phosphatidylglycerol biosynthetic process (GO:0006655)2.97464173
82modulation by virus of host process (GO:0019054)2.95847094
83organelle transport along microtubule (GO:0072384)2.95346031
84response to muramyl dipeptide (GO:0032495)2.94316916
85regulation of neurotransmitter transport (GO:0051588)2.94213719
86prepulse inhibition (GO:0060134)2.93514104
87gamma-aminobutyric acid signaling pathway (GO:0007214)2.91330490
88positive thymic T cell selection (GO:0045059)2.87133111
89thymic T cell selection (GO:0045061)2.86886979
90regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86705412
91regulation of dendritic spine morphogenesis (GO:0061001)2.86488015
92regulation of clathrin-mediated endocytosis (GO:2000369)2.86298808
93transmission of nerve impulse (GO:0019226)2.86121828
94cell migration in hindbrain (GO:0021535)2.85946673
95axonal fasciculation (GO:0007413)2.85393583
96neuronal ion channel clustering (GO:0045161)2.85062596
97potassium ion import (GO:0010107)2.84596595
98axon cargo transport (GO:0008088)2.84374835
99negative regulation of cell size (GO:0045792)2.82077273
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79480693
101response to auditory stimulus (GO:0010996)2.79209045
102membrane depolarization (GO:0051899)2.78902526
103NIK/NF-kappaB signaling (GO:0038061)2.77947285
104potassium ion homeostasis (GO:0055075)2.77510836
105positive regulation of neurotransmitter transport (GO:0051590)2.76658914
106positive regulation by symbiont of host defense response (GO:0052509)2.74728230
107modulation by symbiont of host defense response (GO:0052031)2.74728230
108modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.74728230
109modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.74728230
110positive regulation by organism of defense response of other organism involved in symbiotic interact2.74728230
111modulation by symbiont of host immune response (GO:0052553)2.74728230
112positive regulation of potassium ion transmembrane transport (GO:1901381)2.74323689
113regulation of synaptic transmission, glutamatergic (GO:0051966)2.74260163
114membrane hyperpolarization (GO:0060081)2.74249309
115positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72898474
116neuromuscular process (GO:0050905)2.72690980
117suckling behavior (GO:0001967)2.72397867
118negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71865069
119modulation by symbiont of host cellular process (GO:0044068)2.71580375
120regulation of calcium ion-dependent exocytosis (GO:0017158)2.71009189
121regulation of synaptic transmission (GO:0050804)2.70273343
122positive regulation of synaptic transmission (GO:0050806)2.69807803
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.69443938
124membrane repolarization (GO:0086009)2.69239696
125synaptic transmission (GO:0007268)2.68779069
126alanine transport (GO:0032328)2.68447642
127chemosensory behavior (GO:0007635)2.68394678
128regulation of extracellular matrix disassembly (GO:0010715)2.67020958
129cell-cell junction maintenance (GO:0045217)2.66963233
130regulation of histone deacetylation (GO:0031063)2.63459921
131regulation of hydrogen peroxide metabolic process (GO:0010310)2.61905692
132semaphorin-plexin signaling pathway (GO:0071526)2.60690653
133germinal center formation (GO:0002467)2.60549185
134negative regulation of innate immune response (GO:0045824)2.54126522
135negative regulation of granulocyte differentiation (GO:0030853)2.53915503
136macrophage activation involved in immune response (GO:0002281)2.52847460
137response to peptidoglycan (GO:0032494)2.52701123
138positive regulation of protein deacetylation (GO:0090312)2.52450494
139negative regulation of type 2 immune response (GO:0002829)2.49221317
140antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.48543354
141regulation of gamma-delta T cell activation (GO:0046643)2.45827065
142T cell selection (GO:0045058)2.44503907
143barbed-end actin filament capping (GO:0051016)2.44148208
144regulation of type I interferon-mediated signaling pathway (GO:0060338)2.39376099
145negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.39008875
146histone H4 deacetylation (GO:0070933)2.38280733
147negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.37738732
148activation of MAPKKK activity (GO:0000185)2.34155165
149detection of bacterium (GO:0016045)2.32954233
150positive regulation of protein dephosphorylation (GO:0035307)2.32855219
151positive regulation of protein kinase C signaling (GO:0090037)2.32723992
152regulation of monocyte differentiation (GO:0045655)2.32506633
153positive regulation of Cdc42 GTPase activity (GO:0043089)2.30834767
154amino sugar catabolic process (GO:0046348)2.30279906
155regulation of defense response to virus by virus (GO:0050690)2.29604514
156regulation of leukocyte degranulation (GO:0043300)2.29512926
157regulation of gamma-delta T cell differentiation (GO:0045586)2.29457237
158endothelial cell chemotaxis (GO:0035767)2.26742454
159negative regulation of interleukin-2 production (GO:0032703)2.26443709
160interferon-gamma secretion (GO:0072643)2.23758819
161histone H3 deacetylation (GO:0070932)2.21221864
162regulation of myeloid leukocyte mediated immunity (GO:0002886)2.20332672
163detection of other organism (GO:0098543)2.19609590
164negative regulation of tumor necrosis factor production (GO:0032720)2.19438173
165positive regulation of Rap GTPase activity (GO:0032854)2.19059747
166response to laminar fluid shear stress (GO:0034616)2.18888734
167negative regulation of leukocyte mediated immunity (GO:0002704)2.18802000
168positive T cell selection (GO:0043368)2.18270710
169peptidyl-tyrosine autophosphorylation (GO:0038083)2.17920363
170activation of JUN kinase activity (GO:0007257)2.17573415
171regulation of mast cell degranulation (GO:0043304)2.15790798
172leukocyte aggregation (GO:0070486)2.15637018
173retrograde transport, endosome to Golgi (GO:0042147)2.15064878
174regulation of regulated secretory pathway (GO:1903305)2.14487764
175positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.13620437
176tolerance induction (GO:0002507)2.13397575
177GDP-mannose metabolic process (GO:0019673)2.13372609
178negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.12156976
179N-acetylneuraminate metabolic process (GO:0006054)2.12067730
180positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.11867004
181retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.10744905
182lysosome organization (GO:0007040)2.10574340
183lytic vacuole organization (GO:0080171)2.10574340
184regulation of dendritic cell antigen processing and presentation (GO:0002604)2.10310771
185positive regulation of extracellular matrix organization (GO:1903055)2.09682242
186response to type I interferon (GO:0034340)2.09360476
187regulation of interferon-beta biosynthetic process (GO:0045357)2.07165020
188negative regulation of cytokine production involved in immune response (GO:0002719)2.07042804
189negative regulation of interleukin-6 production (GO:0032715)2.06757338
190negative regulation of lymphocyte mediated immunity (GO:0002707)2.06407071
191intracellular estrogen receptor signaling pathway (GO:0030520)2.05569856
192protein kinase C signaling (GO:0070528)2.05521861
193positive regulation of DNA biosynthetic process (GO:2000573)2.05472789
194regulation of cholesterol storage (GO:0010885)2.05137849
195actin filament polymerization (GO:0030041)2.04864608
196negative thymic T cell selection (GO:0045060)2.04808331

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58711338
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96923955
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96787647
4VDR_21846776_ChIP-Seq_THP-1_Human2.92842055
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.91819350
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.80697113
7DROSHA_22980978_ChIP-Seq_HELA_Human2.80147777
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79114146
9GBX2_23144817_ChIP-Seq_PC3_Human2.70714159
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67560736
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67560736
12REST_21632747_ChIP-Seq_MESCs_Mouse2.64099450
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57730691
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56228173
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55860999
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.44095137
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42921280
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40471399
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33162285
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.32143618
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29540013
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26302378
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.22989646
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22384179
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20836024
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20102563
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.18886385
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18302997
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13342126
30EZH2_27304074_Chip-Seq_ESCs_Mouse2.13032706
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.07883997
32P68_20966046_ChIP-Seq_HELA_Human2.07141192
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06373221
34* MYC_22102868_ChIP-Seq_BL_Human2.05246064
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.97266264
36* RACK7_27058665_Chip-Seq_MCF-7_Human1.97156949
37TCF7_22412390_ChIP-Seq_EML_Mouse1.92496824
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86288396
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.84258383
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79666365
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.76533078
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72972226
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72677187
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.71928500
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.70309700
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68206706
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67990666
48VDR_24763502_ChIP-Seq_THP-1_Human1.67035579
49AR_21572438_ChIP-Seq_LNCaP_Human1.66214026
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.65364809
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.64962651
52BCL6_27268052_Chip-Seq_Bcells_Human1.63752367
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.62661992
54* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60945851
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58851989
56MAF_26560356_Chip-Seq_TH2_Human1.57096972
57KDM2B_26808549_Chip-Seq_K562_Human1.56405458
58BCOR_27268052_Chip-Seq_Bcells_Human1.55190906
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52200108
60MAF_26560356_Chip-Seq_TH1_Human1.50701234
61* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49855084
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49692214
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48917683
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48748669
65* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46357583
66ZNF274_21170338_ChIP-Seq_K562_Hela1.45344399
67* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44442757
68UTX_26944678_Chip-Seq_JUKART_Human1.44051741
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41156362
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.41008212
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39038062
72TP53_22127205_ChIP-Seq_IMR90_Human1.38604021
73SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38185574
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37487854
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.37299392
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36335156
77PHF8_20622854_ChIP-Seq_HELA_Human1.33089425
78SMAD4_21799915_ChIP-Seq_A2780_Human1.32745979
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31422807
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30810041
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.30494569
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30302756
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29909879
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27585922
85SA1_27219007_Chip-Seq_Bcells_Human1.27081629
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26763188
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26005300
88E2F1_20622854_ChIP-Seq_HELA_Human1.25719935
89* TP63_22573176_ChIP-Seq_HFKS_Human1.25306909
90* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24706917
91AR_19668381_ChIP-Seq_PC3_Human1.23973258
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.23277212
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19914936
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19494136
95SPI1_23127762_ChIP-Seq_K562_Human1.19387008
96CTCF_26484167_Chip-Seq_Bcells_Mouse1.18956713
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18086631
98KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16299069
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14465343
100SCL_19346495_ChIP-Seq_HPC-7_Human1.13644641
101ESR1_21235772_ChIP-Seq_MCF-7_Human1.13637085
102RARB_24833708_ChIP-Seq_LIVER_Mouse1.13336087
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12900583
104OCT4_19829295_ChIP-Seq_ESCs_Human1.12572629
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11320492
106CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10518430
107MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10283996
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09833035
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08955936
110CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08783487
111* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08344986
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08149538
113CTCF_20526341_ChIP-Seq_ESCs_Human1.07489218
114CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06597053
115NCOR1_26117541_ChIP-Seq_K562_Human1.06430210
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06180373
117TET1_21490601_ChIP-Seq_MESCs_Mouse1.05713376
118CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05232395
119* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05132046
120STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04907588
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04698204
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03681065
123RING1B_27294783_Chip-Seq_NPCs_Mouse1.02732636
124* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02671135
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02017690
126STAT3_23295773_ChIP-Seq_U87_Human1.01927410
127YY1_22570637_ChIP-Seq_MALME-3M_Human1.01748853
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01057104
129* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00896373
130ZNF263_19887448_ChIP-Seq_K562_Human0.99538627
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99520890
132AR_25329375_ChIP-Seq_VCAP_Human0.99437774
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99289027
134SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98981657
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98571140
136* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98282346
137JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97256200
138* LXR_22292898_ChIP-Seq_THP-1_Human0.97246585
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96460569
140SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96444728
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96167881
142BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95742014
143CTCF_27219007_Chip-Seq_Bcells_Human0.95652783
144PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95600204
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95261313
146KDM2B_26808549_Chip-Seq_DND41_Human0.94416560
147TAF15_26573619_Chip-Seq_HEK293_Human0.93945105
148P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93877380
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.93777775
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.93074579
151RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92947074
152* AHR_22903824_ChIP-Seq_MCF-7_Human0.92482040
153TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92265942
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.91803809
155SMAD_19615063_ChIP-ChIP_OVARY_Human0.91102341
156* ARNT_22903824_ChIP-Seq_MCF-7_Human0.90995842
157SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90253374
158TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88284304
159RXR_22108803_ChIP-Seq_LS180_Human0.87975811
160TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86886128
161TCF4_23295773_ChIP-Seq_U87_Human0.85906342
162OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85373495
163SMAD3_21741376_ChIP-Seq_EPCs_Human0.85085126
164KDM2B_26808549_Chip-Seq_JURKAT_Human0.84552818
165CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82593224
166KLF4_19829295_ChIP-Seq_ESCs_Human0.82283046
167SMC4_20622854_ChIP-Seq_HELA_Human0.81872139
168CREB1_26743006_Chip-Seq_LNCaP_Human0.81861669
169PIAS1_25552417_ChIP-Seq_VCAP_Human0.81709906
170BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80974827
171* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80197041
172SMAD3_21741376_ChIP-Seq_HESCs_Human0.79499661
173SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79338333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.30530868
2MP0003635_abnormal_synaptic_transmissio4.00594721
3MP0003880_abnormal_central_pattern3.99959653
4MP0004270_analgesia3.79963289
5MP0005058_abnormal_lysosome_morphology3.78734662
6MP0003436_decreased_susceptibility_to3.09145233
7MP0009745_abnormal_behavioral_response3.08761740
8MP0002063_abnormal_learning/memory/cond3.05992622
9MP0009046_muscle_twitch3.01245436
10MP0002064_seizures2.99771159
11MP0001968_abnormal_touch/_nociception2.89638766
12MP0009278_abnormal_bone_marrow2.83635486
13MP0009840_abnormal_foam_cell2.73236329
14MP0003705_abnormal_hypodermis_morpholog2.65484889
15MP0003303_peritoneal_inflammation2.62047178
16MP0002734_abnormal_mechanical_nocicepti2.61384606
17MP0005423_abnormal_somatic_nervous2.57916345
18MP0002909_abnormal_adrenal_gland2.53252302
19MP0009780_abnormal_chondrocyte_physiolo2.49843714
20MP0002572_abnormal_emotion/affect_behav2.49575056
21MP0002822_catalepsy2.43925357
22MP0002272_abnormal_nervous_system2.41828573
23MP0004858_abnormal_nervous_system2.37129259
24MP0003329_amyloid_beta_deposits2.32018275
25MP0001501_abnormal_sleep_pattern2.20167221
26MP0002733_abnormal_thermal_nociception2.18268358
27MP0002735_abnormal_chemical_nociception2.16436449
28MP0001486_abnormal_startle_reflex2.15617689
29MP0002736_abnormal_nociception_after2.14479335
30MP0008260_abnormal_autophagy1.98946984
31MP0001970_abnormal_pain_threshold1.97277984
32MP0008569_lethality_at_weaning1.96182769
33MP0001958_emphysema1.94703401
34MP0001440_abnormal_grooming_behavior1.89490880
35MP0002067_abnormal_sensory_capabilities1.88353254
36MP0003724_increased_susceptibility_to1.87378656
37MP0004811_abnormal_neuron_physiology1.84476318
38MP0001790_abnormal_immune_system1.83375774
39MP0005387_immune_system_phenotype1.83375774
40MP0005025_abnormal_response_to1.82718572
41MP0002184_abnormal_innervation1.78243322
42MP0002419_abnormal_innate_immunity1.77746921
43MP0000685_abnormal_immune_system1.73091075
44MP0001533_abnormal_skeleton_physiology1.69530595
45MP0006276_abnormal_autonomic_nervous1.69076647
46MP0002557_abnormal_social/conspecific_i1.64379040
47MP0000955_abnormal_spinal_cord1.63815222
48MP0003122_maternal_imprinting1.63526138
49MP0005386_behavior/neurological_phenoty1.62666412
50MP0004924_abnormal_behavior1.62666412
51MP0005000_abnormal_immune_tolerance1.61829995
52MP0001800_abnormal_humoral_immune1.59820144
53MP0006082_CNS_inflammation1.58718270
54MP0003879_abnormal_hair_cell1.58340968
55MP0003279_aneurysm1.57976758
56MP0004947_skin_inflammation1.57701567
57MP0004381_abnormal_hair_follicle1.57279436
58MP0000013_abnormal_adipose_tissue1.55247051
59MP0008961_abnormal_basal_metabolism1.50357197
60MP0001873_stomach_inflammation1.47646607
61MP0002723_abnormal_immune_serum1.47589161
62MP0002933_joint_inflammation1.46511238
63MP0005076_abnormal_cell_differentiation1.45850011
64MP0001849_ear_inflammation1.45694489
65MP0000778_abnormal_nervous_system1.45646122
66MP0001835_abnormal_antigen_presentation1.44238667
67MP0003283_abnormal_digestive_organ1.41287214
68MP0000569_abnormal_digit_pigmentation1.40830093
69MP0002452_abnormal_antigen_presenting1.40518810
70MP0002066_abnormal_motor_capabilities/c1.38160061
71MP0005451_abnormal_body_composition1.38033917
72MP0005671_abnormal_response_to1.37267316
73MP0002420_abnormal_adaptive_immunity1.36940707
74MP0003787_abnormal_imprinting1.36652282
75MP0005645_abnormal_hypothalamus_physiol1.36397571
76MP0001819_abnormal_immune_cell1.35586460
77MP0002882_abnormal_neuron_morphology1.35162645
78MP0005646_abnormal_pituitary_gland1.34996891
79MP0003633_abnormal_nervous_system1.33764890
80MP0001502_abnormal_circadian_rhythm1.30511125
81MP0000751_myopathy1.30329578
82MP0004885_abnormal_endolymph1.30266333
83MP0010155_abnormal_intestine_physiology1.26703918
84MP0002998_abnormal_bone_remodeling1.26100746
85MP0002837_dystrophic_cardiac_calcinosis1.23052698
86MP0004145_abnormal_muscle_electrophysio1.22970318
87MP0010386_abnormal_urinary_bladder1.22669114
88MP0005397_hematopoietic_system_phenotyp1.20644765
89MP0001545_abnormal_hematopoietic_system1.20644765
90MP0003763_abnormal_thymus_physiology1.20295707
91MP0003866_abnormal_defecation1.19685651
92MP0002148_abnormal_hypersensitivity_rea1.19478471
93MP0003300_gastrointestinal_ulcer1.19210677
94MP0001984_abnormal_olfaction1.18359046
95MP0003183_abnormal_peptide_metabolism1.15701592
96MP0003191_abnormal_cellular_cholesterol1.12749588
97MP0002653_abnormal_ependyma_morphology1.11619561
98MP0000604_amyloidosis1.10317280
99MP0003172_abnormal_lysosome_physiology1.09235289
100MP0003631_nervous_system_phenotype1.08902468
101MP0009384_cardiac_valve_regurgitation1.07862214
102MP0000858_altered_metastatic_potential1.07487075
103MP0009333_abnormal_splenocyte_physiolog1.06945028
104MP0002405_respiratory_system_inflammati1.05875228
105MP0002089_abnormal_postnatal_growth/wei1.05445346
106MP0005464_abnormal_platelet_physiology1.04670222
107MP0004142_abnormal_muscle_tone1.02853293
108MP0005390_skeleton_phenotype1.02640380
109MP0002249_abnormal_larynx_morphology1.02086494
110MP0000716_abnormal_immune_system1.02045881
111MP0008438_abnormal_cutaneous_collagen1.01673166
112MP0002152_abnormal_brain_morphology1.01179265
113MP0002229_neurodegeneration0.99262891
114MP0009764_decreased_sensitivity_to0.98823758
115MP0002069_abnormal_eating/drinking_beha0.97837461
116MP0005535_abnormal_body_temperature0.97213491
117MP0005409_darkened_coat_color0.95732146
118MP0010234_abnormal_vibrissa_follicle0.94137690
119MP0005360_urolithiasis0.93519638
120MP0000015_abnormal_ear_pigmentation0.93452486
121MP0001663_abnormal_digestive_system0.93402772
122MP0004233_abnormal_muscle_weight0.92265132
123MP0009785_altered_susceptibility_to0.92219486
124MP0001845_abnormal_inflammatory_respons0.92163246
125MP0003634_abnormal_glial_cell0.91676225
126MP0008874_decreased_physiological_sensi0.91029821
127MP0008872_abnormal_physiological_respon0.88671003
128MP0001905_abnormal_dopamine_level0.88348013
129MP0008469_abnormal_protein_level0.87290241
130MP0001299_abnormal_eye_distance/0.86781894
131MP0005503_abnormal_tendon_morphology0.85632630
132MP0004043_abnormal_pH_regulation0.85431582
133MP0004085_abnormal_heartbeat0.84530897
134MP0005623_abnormal_meninges_morphology0.82429115
135MP0002398_abnormal_bone_marrow0.82257811
136MP0003045_fibrosis0.82139087
137MP0003075_altered_response_to0.81529771
138MP0000678_abnormal_parathyroid_gland0.80519232
139MP0000681_abnormal_thyroid_gland0.79892891
140MP0001986_abnormal_taste_sensitivity0.78642416
141MP0004130_abnormal_muscle_cell0.78417063
142MP0002429_abnormal_blood_cell0.78244457
143MP0002090_abnormal_vision0.78217239
144MP0000747_muscle_weakness0.77966656
145MP0005381_digestive/alimentary_phenotyp0.77770842
146MP0003632_abnormal_nervous_system0.77604573
147MP0003453_abnormal_keratinocyte_physiol0.76153573
148MP0005670_abnormal_white_adipose0.74377177
149MP0001177_atelectasis0.74265010
150MP0003690_abnormal_glial_cell0.74213754
151MP0005375_adipose_tissue_phenotype0.74158294
152MP0005257_abnormal_intraocular_pressure0.73492591
153MP0000003_abnormal_adipose_tissue0.73332957
154MP0005377_hearing/vestibular/ear_phenot0.72562937
155MP0003878_abnormal_ear_physiology0.72562937
156MP0001664_abnormal_digestion0.71745785
157MP0000750_abnormal_muscle_regeneration0.71439746
158MP0003091_abnormal_cell_migration0.69343364
159MP0005310_abnormal_salivary_gland0.68825532
160MP0002970_abnormal_white_adipose0.67747936
161MP0000920_abnormal_myelination0.64147533
162MP0001348_abnormal_lacrimal_gland0.63903647
163MP0004742_abnormal_vestibular_system0.60616375
164MP0005551_abnormal_eye_electrophysiolog0.59449546
165MP0005394_taste/olfaction_phenotype0.58616894
166MP0005499_abnormal_olfactory_system0.58616894
167MP0001529_abnormal_vocalization0.58133196
168MP0005448_abnormal_energy_balance0.57517203
169MP0002752_abnormal_somatic_nervous0.57381669
170MP0004510_myositis0.56606818
171MP0001943_abnormal_respiration0.56294636
172MP0002078_abnormal_glucose_homeostasis0.56269138
173MP0001963_abnormal_hearing_physiology0.56099809
174MP0003123_paternal_imprinting0.56074171
175MP0005187_abnormal_penis_morphology0.55466949
176MP0010769_abnormal_survival0.55186750
177MP0001944_abnormal_pancreas_morphology0.54886447

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.19489838
2Myokymia (HP:0002411)6.04681133
3Visual hallucinations (HP:0002367)5.43638021
4Focal seizures (HP:0007359)5.08434762
5Atonic seizures (HP:0010819)4.13251197
6Supranuclear gaze palsy (HP:0000605)4.10832969
7Action tremor (HP:0002345)3.94123830
8Progressive cerebellar ataxia (HP:0002073)3.92492994
9Epileptic encephalopathy (HP:0200134)3.77987084
10Obstructive sleep apnea (HP:0002870)3.75777569
11Absence seizures (HP:0002121)3.70641830
12Dysostosis multiplex (HP:0000943)3.60671650
13J-shaped sella turcica (HP:0002680)3.50643932
14Febrile seizures (HP:0002373)3.50487386
15Ankle clonus (HP:0011448)3.49211064
16Generalized tonic-clonic seizures (HP:0002069)3.48418445
17Abnormality of polysaccharide metabolism (HP:0011012)3.33051323
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.33051323
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.33051323
20Depression (HP:0000716)3.32347001
21Dialeptic seizures (HP:0011146)3.25604917
22Urinary glycosaminoglycan excretion (HP:0003541)3.24078946
23Mucopolysacchariduria (HP:0008155)3.24078946
24Increased cerebral lipofuscin (HP:0011813)3.20741505
25Abnormality of glycolipid metabolism (HP:0010969)3.15625850
26Abnormality of liposaccharide metabolism (HP:0010968)3.15625850
27Abnormality of glycosphingolipid metabolism (HP:0004343)3.15625850
28Thin bony cortex (HP:0002753)3.12613738
29Eczematoid dermatitis (HP:0000976)3.10638750
30Papilledema (HP:0001085)3.06725978
31Pheochromocytoma (HP:0002666)3.01727690
32Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.98873787
33Cerebral aneurysm (HP:0004944)2.97800909
34Poor eye contact (HP:0000817)2.95868972
35Impaired vibration sensation in the lower limbs (HP:0002166)2.94009850
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.92515208
37Truncal ataxia (HP:0002078)2.92134134
38Abnormal social behavior (HP:0012433)2.90621926
39Impaired social interactions (HP:0000735)2.90621926
40Postural instability (HP:0002172)2.83459292
41Cervical subluxation (HP:0003308)2.78323460
42Dysdiadochokinesis (HP:0002075)2.76723263
43Abnormal eating behavior (HP:0100738)2.76403950
44Anxiety (HP:0000739)2.75863766
45Urinary bladder sphincter dysfunction (HP:0002839)2.75824896
46Ventricular fibrillation (HP:0001663)2.70550725
47Joint stiffness (HP:0001387)2.70528782
48Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.70475935
49Abnormality of the lower motor neuron (HP:0002366)2.68919271
50Urinary urgency (HP:0000012)2.67064179
51Neuroendocrine neoplasm (HP:0100634)2.65720080
52Hemiplegia (HP:0002301)2.64910300
53Dysmetria (HP:0001310)2.60773387
54Abnormality of macrophages (HP:0004311)2.59163338
55Amblyopia (HP:0000646)2.56689793
56Genetic anticipation (HP:0003743)2.54521725
57Spastic gait (HP:0002064)2.54427543
58Agitation (HP:0000713)2.51901864
59Insidious onset (HP:0003587)2.51096380
60Termporal pattern (HP:0011008)2.51096380
61Protrusio acetabuli (HP:0003179)2.50227719
62Impaired smooth pursuit (HP:0007772)2.50052260
63Insomnia (HP:0100785)2.47637780
64Loss of speech (HP:0002371)2.46713404
65Cerebral inclusion bodies (HP:0100314)2.46437510
66Gaze-evoked nystagmus (HP:0000640)2.46213535
67Stridor (HP:0010307)2.45216460
68Dysmetric saccades (HP:0000641)2.43573922
69Hypercortisolism (HP:0001578)2.43356549
70Broad-based gait (HP:0002136)2.42483597
71Torticollis (HP:0000473)2.41194941
72Broad face (HP:0000283)2.41134238
73Mutism (HP:0002300)2.40342528
74Atelectasis (HP:0100750)2.40194199
75Myositis (HP:0100614)2.39653767
76EEG with generalized epileptiform discharges (HP:0011198)2.38969705
77Hemorrhage of the eye (HP:0011885)2.38519344
78Epileptiform EEG discharges (HP:0011182)2.38454987
79Scanning speech (HP:0002168)2.35743517
80Megalencephaly (HP:0001355)2.34743077
81Elevated erythrocyte sedimentation rate (HP:0003565)2.33637374
82Hypsarrhythmia (HP:0002521)2.32446191
83Abnormality of the nasal mucosa (HP:0000433)2.29953201
84Lymphangioma (HP:0100764)2.29316279
85Bradykinesia (HP:0002067)2.29165138
86Hypertensive crisis (HP:0100735)2.28712481
87Increased IgE level (HP:0003212)2.28221948
88Hypoventilation (HP:0002791)2.27803375
89Pointed chin (HP:0000307)2.26395861
90Focal dystonia (HP:0004373)2.25908480
91Emphysema (HP:0002097)2.24831767
92Neurofibrillary tangles (HP:0002185)2.24711468
93Status epilepticus (HP:0002133)2.24281263
94Abnormality of the thoracic spine (HP:0100711)2.23516414
95Systemic lupus erythematosus (HP:0002725)2.22784229
96Colitis (HP:0002583)2.22577275
97Failure to thrive in infancy (HP:0001531)2.20839204
98Bundle branch block (HP:0011710)2.19213065
99Intention tremor (HP:0002080)2.15788474
100Lower limb muscle weakness (HP:0007340)2.15269303
101Biconcave vertebral bodies (HP:0004586)2.15176512
102Hand muscle atrophy (HP:0009130)2.15017624
103Neoplasm of the peripheral nervous system (HP:0100007)2.14576688
104Progressive inability to walk (HP:0002505)2.13815733
105Thoracic kyphosis (HP:0002942)2.12813493
106Limb dystonia (HP:0002451)2.12609267
107Abnormality of ocular smooth pursuit (HP:0000617)2.11175639
108Rapidly progressive (HP:0003678)2.10843776
109Abnormality of binocular vision (HP:0011514)2.10840742
110Diplopia (HP:0000651)2.10840742
111Hemiparesis (HP:0001269)2.10751161
112Neoplasm of the heart (HP:0100544)2.09575291
113Increased serum ferritin (HP:0003281)2.08928793
114Gastrointestinal infarctions (HP:0005244)2.07348782
115Long palpebral fissure (HP:0000637)2.06937475
116Mitral regurgitation (HP:0001653)2.06404761
117Stereotypic behavior (HP:0000733)2.06261503
118Chronic obstructive pulmonary disease (HP:0006510)2.05801525
119Obstructive lung disease (HP:0006536)2.05801525
120Resting tremor (HP:0002322)2.05563967
121Nasal polyposis (HP:0100582)2.05554528
122Deformed sella turcica (HP:0002681)2.04051273
123Mediastinal lymphadenopathy (HP:0100721)2.03742533
124Pustule (HP:0200039)2.03656790
125Drooling (HP:0002307)2.03571963
126Excessive salivation (HP:0003781)2.03571963
127Hyperventilation (HP:0002883)2.01967831
128Craniofacial dystonia (HP:0012179)2.01515420
129Neuronal loss in central nervous system (HP:0002529)2.01496848
130Macroorchidism (HP:0000053)2.01149712
131Cellulitis (HP:0100658)1.99565380
132Psychosis (HP:0000709)1.96978408
133Postural tremor (HP:0002174)1.95553401
134Recurrent abscess formation (HP:0002722)1.94583039
135Aortic regurgitation (HP:0001659)1.92478676
136Supernumerary nipples (HP:0002558)1.92462664
137Clonus (HP:0002169)1.91699986
138Hyperacusis (HP:0010780)1.90846563
139Hyperthyroidism (HP:0000836)1.90761550
140Recurrent fungal infections (HP:0002841)1.89549789
141Bronchomalacia (HP:0002780)1.88789778
142Abnormality of the corticospinal tract (HP:0002492)1.88594919
143Distal lower limb muscle weakness (HP:0009053)1.88360629
144Rigidity (HP:0002063)1.87797649
145Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.87534696
146Polygenic inheritance (HP:0010982)1.86582976
147Vacuolated lymphocytes (HP:0001922)1.86472913
148Orchitis (HP:0100796)1.85836319
149Peritonitis (HP:0002586)1.85302986
150Abnormality of the fingertips (HP:0001211)1.85061091
151Generalized myoclonic seizures (HP:0002123)1.85008860
152Ulnar bowing (HP:0003031)1.84506345
153Recurrent gram-negative bacterial infections (HP:0005420)1.84231242
154Nuclear cataract (HP:0100018)1.83616638
155Lower limb asymmetry (HP:0100559)1.81652534
156Upper limb amyotrophy (HP:0009129)1.81608528
157Distal upper limb amyotrophy (HP:0007149)1.81608528
158Myotonia (HP:0002486)1.80449808
159Impaired vibratory sensation (HP:0002495)1.80417471
160Seborrheic dermatitis (HP:0001051)1.79354260
161Distal lower limb amyotrophy (HP:0008944)1.79181384
162Annular pancreas (HP:0001734)1.78765958
163Purpura (HP:0000979)1.77289833
164Hypertriglyceridemia (HP:0002155)1.77263699
165Hammertoe (HP:0001765)1.77256890
166Impaired pain sensation (HP:0007328)1.76731137
167Abnormality of pain sensation (HP:0010832)1.76731137
168Gait ataxia (HP:0002066)1.76646332
169Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76104844
170Recurrent bacterial skin infections (HP:0005406)1.76097826
171Gastrointestinal inflammation (HP:0004386)1.75145606
172Aneurysm (HP:0002617)1.74585176
173Spinal canal stenosis (HP:0003416)1.74397225
174Abnormality of calcium-phosphate metabolism (HP:0100530)1.74340098
175Global brain atrophy (HP:0002283)1.72628297
176Interstitial pulmonary disease (HP:0006530)1.72483253
177Gingivitis (HP:0000230)1.70168909
178Bladder diverticulum (HP:0000015)1.68721518
179Disproportionate tall stature (HP:0001519)1.68563082
180Mesangial abnormality (HP:0001966)1.68485350
181Clumsiness (HP:0002312)1.68433422
182Long toe (HP:0010511)1.66972896
183Achilles tendon contracture (HP:0001771)1.65781767
184Easy fatigability (HP:0003388)1.65759432
185Segmental peripheral demyelination/remyelination (HP:0003481)1.64111156
186Turricephaly (HP:0000262)1.63986866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.15315263
2MAP3K93.94544853
3ERN13.02067428
4EPHA42.93423618
5MAP3K42.84925345
6MINK12.80218553
7SIK12.61702581
8KSR22.52412162
9MARK12.48626431
10DAPK22.45400153
11PAK62.44849568
12MAP4K12.38177562
13NTRK12.32321948
14MAP3K112.21670048
15PRKD32.19274950
16CAMKK12.15074568
17TAOK32.06951397
18MAP2K41.88477774
19MAP2K71.84968878
20MAP2K31.83989585
21NTRK21.83478895
22PRKD21.82190945
23MAP3K21.78104353
24MAP3K121.74975588
25RIPK41.73080816
26ICK1.71708364
27FGFR41.56765835
28KSR11.53719138
29CDK51.52630899
30LMTK21.50396595
31RET1.49674088
32CAMKK21.48328166
33STK381.44239807
34TBK11.43996213
35IRAK31.41733654
36TRIB31.41518290
37DAPK11.40410516
38EEF2K1.36329288
39SIK21.35835019
40SMG11.32219465
41EPHB11.31361264
42TYK21.31283361
43MAP3K131.30001898
44PRKCH1.26448608
45UHMK11.25714723
46ARAF1.21270435
47CDK191.21240364
48PTK61.19515824
49SCYL21.18767387
50ZAP701.18371216
51RIPK11.15188848
52GRK51.14108773
53GRK61.11206920
54TAOK11.10641082
55PHKG11.10168132
56PHKG21.10168132
57MAP3K31.10151755
58BLK1.09787452
59TYRO31.09499387
60PAK31.08141847
61LATS21.07934112
62MAP2K61.06286046
63PRPF4B1.04503844
64MAPKAPK31.02345487
65FES1.02325454
66PRKCG0.99884286
67JAK30.99625720
68ALK0.98427725
69TESK10.97962714
70MAP2K20.97789634
71PLK20.97630929
72MAPK150.95202841
73MAPK120.92530875
74PKN20.91652628
75CAMK1G0.89920276
76MAP3K60.88885398
77MAP3K10.88706665
78FER0.87183906
79WNK10.87011451
80CSK0.86116321
81MAPK130.83635756
82SGK2230.82301357
83SGK4940.82301357
84RPS6KC10.82050844
85RPS6KL10.82050844
86PNCK0.81165312
87CDC42BPA0.81022498
88CAMK10.80754193
89CDK140.79409331
90BTK0.78017455
91CDK180.77817037
92RPS6KA60.77759256
93STK110.77621466
94CDK150.77387039
95DYRK1B0.77263913
96SGK30.76870469
97IRAK40.74166026
98MTOR0.73966306
99IKBKE0.71856490
100PDGFRA0.71666825
101TAOK20.71579903
102CHUK0.71517640
103CAMK2A0.71219454
104IKBKB0.69326161
105PDPK10.68854647
106NME20.68733740
107MAP2K10.68344434
108PDK10.68130167
109CDK11A0.66324195
110RAF10.64452659
111RPS6KA20.64427360
112PIM20.63377210
113MAP3K140.63292482
114MAPK110.63023747
115TTN0.62764966
116HCK0.60980140
117JAK10.60896027
118DAPK30.60782223
119CSNK1G20.60552787
120CSF1R0.59565753
121TESK20.58746883
122NEK10.58381362
123CDK120.58222180
124SGK20.57982935
125PTK2B0.56969591
126MARK20.55798101
127SYK0.54068806
128SGK10.53793630
129LCK0.52779231
130PRKCZ0.52575093
131CAMK2B0.52313200
132EPHA20.51578793
133MAP3K70.51018631
134PRKD10.50118522
135MAPK70.50037215
136DMPK0.48989995
137KIT0.48917567
138TNK20.48492118
139DYRK1A0.48347636
140PINK10.47822594
141PTK20.47785879
142RPS6KA30.47429067
143BMX0.46918676
144FYN0.46767463
145CAMK2D0.45907109
146ROCK20.45821431
147TNIK0.45784524
148PRKG20.45630521
149MAPK100.45589813
150FGR0.45353230
151LIMK10.43234762
152DDR20.43000185
153WNK40.42537805
154LRRK20.41284635
155ITK0.41015811
156CASK0.39585163
157CAMK40.39061778
158EPHA30.38772553
159PRKCE0.38687384
160CAMK2G0.37820791
161ABL20.37447512
162ROCK10.37290185
163HIPK20.36663778

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.75815408
2Synaptic vesicle cycle_Homo sapiens_hsa047213.31219766
3Nicotine addiction_Homo sapiens_hsa050332.82041704
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.66149738
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.51895177
6Long-term potentiation_Homo sapiens_hsa047202.41575574
7GABAergic synapse_Homo sapiens_hsa047272.38747137
8Circadian entrainment_Homo sapiens_hsa047132.33913375
9Olfactory transduction_Homo sapiens_hsa047402.33251515
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22123089
11Insulin secretion_Homo sapiens_hsa049112.13145100
12Glutamatergic synapse_Homo sapiens_hsa047242.11981555
13Amphetamine addiction_Homo sapiens_hsa050312.11935584
14Morphine addiction_Homo sapiens_hsa050322.06561097
15Dopaminergic synapse_Homo sapiens_hsa047282.02604458
16Lysosome_Homo sapiens_hsa041421.94433671
17Salivary secretion_Homo sapiens_hsa049701.92443551
18Gastric acid secretion_Homo sapiens_hsa049711.86686490
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.85750320
20Acute myeloid leukemia_Homo sapiens_hsa052211.83244402
21Cholinergic synapse_Homo sapiens_hsa047251.82035748
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78682797
23Notch signaling pathway_Homo sapiens_hsa043301.78357516
24Osteoclast differentiation_Homo sapiens_hsa043801.77787722
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70684486
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66486458
27B cell receptor signaling pathway_Homo sapiens_hsa046621.61390929
28Cocaine addiction_Homo sapiens_hsa050301.59689165
29Taste transduction_Homo sapiens_hsa047421.56063415
30Long-term depression_Homo sapiens_hsa047301.52806286
31Oxytocin signaling pathway_Homo sapiens_hsa049211.48002699
32Renin secretion_Homo sapiens_hsa049241.46315566
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45880088
34Type II diabetes mellitus_Homo sapiens_hsa049301.45054994
35GnRH signaling pathway_Homo sapiens_hsa049121.42871917
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.39839226
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37509544
38Serotonergic synapse_Homo sapiens_hsa047261.34669929
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34393122
40Gap junction_Homo sapiens_hsa045401.33872998
41Collecting duct acid secretion_Homo sapiens_hsa049661.30670629
42Estrogen signaling pathway_Homo sapiens_hsa049151.28787722
43Calcium signaling pathway_Homo sapiens_hsa040201.26916786
44Glioma_Homo sapiens_hsa052141.23781781
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22779859
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20546189
47Staphylococcus aureus infection_Homo sapiens_hsa051501.19424057
48Leishmaniasis_Homo sapiens_hsa051401.17221706
49Sulfur relay system_Homo sapiens_hsa041221.17008040
50Pancreatic secretion_Homo sapiens_hsa049721.16969197
51TNF signaling pathway_Homo sapiens_hsa046681.16578014
52Vibrio cholerae infection_Homo sapiens_hsa051101.15656948
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12502634
54cAMP signaling pathway_Homo sapiens_hsa040241.12230342
55Tuberculosis_Homo sapiens_hsa051521.10806650
56T cell receptor signaling pathway_Homo sapiens_hsa046601.10108945
57Nitrogen metabolism_Homo sapiens_hsa009101.09738143
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06436750
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04971507
60NF-kappa B signaling pathway_Homo sapiens_hsa040641.03335271
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02276780
62ErbB signaling pathway_Homo sapiens_hsa040121.02094497
63Hepatitis C_Homo sapiens_hsa051601.02026137
64Melanogenesis_Homo sapiens_hsa049160.99058195
65Chronic myeloid leukemia_Homo sapiens_hsa052200.98721820
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.95868041
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95809367
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95440896
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.94108108
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92717300
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91750322
72Fructose and mannose metabolism_Homo sapiens_hsa000510.90829192
73Primary immunodeficiency_Homo sapiens_hsa053400.90409903
74Thyroid hormone synthesis_Homo sapiens_hsa049180.89349142
75Toxoplasmosis_Homo sapiens_hsa051450.89183362
76Dorso-ventral axis formation_Homo sapiens_hsa043200.88900331
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88511578
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.86830367
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.86808739
80Pertussis_Homo sapiens_hsa051330.86761248
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86541389
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.86471894
83Malaria_Homo sapiens_hsa051440.84858546
84Axon guidance_Homo sapiens_hsa043600.84262727
85Graft-versus-host disease_Homo sapiens_hsa053320.82159965
86Allograft rejection_Homo sapiens_hsa053300.81489949
87mTOR signaling pathway_Homo sapiens_hsa041500.81374504
88Dilated cardiomyopathy_Homo sapiens_hsa054140.79741671
89VEGF signaling pathway_Homo sapiens_hsa043700.78187626
90Bladder cancer_Homo sapiens_hsa052190.77417131
91Cardiac muscle contraction_Homo sapiens_hsa042600.75345180
92Influenza A_Homo sapiens_hsa051640.73455287
93Choline metabolism in cancer_Homo sapiens_hsa052310.73355157
94Endometrial cancer_Homo sapiens_hsa052130.71157685
95Glucagon signaling pathway_Homo sapiens_hsa049220.70956920
96Autoimmune thyroid disease_Homo sapiens_hsa053200.70630635
97ABC transporters_Homo sapiens_hsa020100.70538198
98Insulin signaling pathway_Homo sapiens_hsa049100.69445616
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.69411428
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69259545
101MAPK signaling pathway_Homo sapiens_hsa040100.67912184
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66792215
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65940490
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65909350
105Oocyte meiosis_Homo sapiens_hsa041140.65842849
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.65061395
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65021515
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64064477
109Non-small cell lung cancer_Homo sapiens_hsa052230.61979217
110Hepatitis B_Homo sapiens_hsa051610.61598915
111Endocytosis_Homo sapiens_hsa041440.60920323
112Inositol phosphate metabolism_Homo sapiens_hsa005620.59880652
113Apoptosis_Homo sapiens_hsa042100.57986355
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56735816
115Salmonella infection_Homo sapiens_hsa051320.55719434
116Type I diabetes mellitus_Homo sapiens_hsa049400.55679207
117Renal cell carcinoma_Homo sapiens_hsa052110.55219738
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55137187
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55099624
120Bile secretion_Homo sapiens_hsa049760.54904044
121Amoebiasis_Homo sapiens_hsa051460.54517479
122Rap1 signaling pathway_Homo sapiens_hsa040150.54294331
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53081393
124Phagosome_Homo sapiens_hsa041450.52929473
125Pancreatic cancer_Homo sapiens_hsa052120.52726422
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52023458
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51644692
128AMPK signaling pathway_Homo sapiens_hsa041520.51463552
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51438675
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.51365544
131HIF-1 signaling pathway_Homo sapiens_hsa040660.50236313
132Prion diseases_Homo sapiens_hsa050200.49644205
133Ras signaling pathway_Homo sapiens_hsa040140.49337227
134Prolactin signaling pathway_Homo sapiens_hsa049170.48338162
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.47821470
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44874205
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44584958
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44401099
139Alcoholism_Homo sapiens_hsa050340.43899486
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43248298
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42144938
142Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41031364
143Chemokine signaling pathway_Homo sapiens_hsa040620.36778863
144Circadian rhythm_Homo sapiens_hsa047100.35939960
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35611345
146Colorectal cancer_Homo sapiens_hsa052100.33392284
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32641426
148Platelet activation_Homo sapiens_hsa046110.32589349
149Insulin resistance_Homo sapiens_hsa049310.31730618
150Phototransduction_Homo sapiens_hsa047440.30825815

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