TCF3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.63296960
2positive regulation by symbiont of host defense response (GO:0052509)5.42029981
3modulation by symbiont of host defense response (GO:0052031)5.42029981
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.42029981
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.42029981
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.42029981
7modulation by symbiont of host immune response (GO:0052553)5.42029981
8response to peptidoglycan (GO:0032494)5.06371703
9cellular extravasation (GO:0045123)4.98837014
10regulation of gamma-delta T cell activation (GO:0046643)4.98290748
11neutrophil activation involved in immune response (GO:0002283)4.96930437
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.85567795
13detection of molecule of bacterial origin (GO:0032490)4.78450783
14negative regulation of interleukin-12 production (GO:0032695)4.63132040
15macrophage activation involved in immune response (GO:0002281)4.59865076
16regulation of gamma-delta T cell differentiation (GO:0045586)4.28496770
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.97874393
18germinal center formation (GO:0002467)3.89683657
19detection of other organism (GO:0098543)3.86894892
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.83317199
21negative regulation of cell killing (GO:0031342)3.83317199
22microglial cell activation (GO:0001774)3.82900991
23negative regulation of erythrocyte differentiation (GO:0045647)3.80241751
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.79958716
25response to host immune response (GO:0052572)3.79958716
26response to muramyl dipeptide (GO:0032495)3.79086650
27positive regulation of B cell differentiation (GO:0045579)3.78812440
28regulation of B cell receptor signaling pathway (GO:0050855)3.71696936
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.71011655
30T cell migration (GO:0072678)3.70573189
31immunoglobulin mediated immune response (GO:0016064)3.69802331
32macrophage activation (GO:0042116)3.69450898
33detection of external biotic stimulus (GO:0098581)3.68338090
34negative regulation of T cell mediated immunity (GO:0002710)3.64844687
35regulation of dendritic cell antigen processing and presentation (GO:0002604)3.60616067
36regulation of mast cell degranulation (GO:0043304)3.59103832
37regulation of interferon-beta biosynthetic process (GO:0045357)3.55724195
38positive regulation of granulocyte differentiation (GO:0030854)3.55123558
39neutrophil activation (GO:0042119)3.54317525
40myeloid cell activation involved in immune response (GO:0002275)3.50395992
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.47636160
42response to host (GO:0075136)3.47636160
43response to host defenses (GO:0052200)3.47636160
44neutrophil mediated immunity (GO:0002446)3.41525875
45defense response to protozoan (GO:0042832)3.39501727
46detection of bacterium (GO:0016045)3.38728235
47positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.37316567
48detection of biotic stimulus (GO:0009595)3.36207891
49granulocyte activation (GO:0036230)3.36191358
50erythrocyte development (GO:0048821)3.35047445
51regulation of hypersensitivity (GO:0002883)3.32368124
52lipopolysaccharide-mediated signaling pathway (GO:0031663)3.32212868
53regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.31170485
54positive regulation of mast cell activation (GO:0033005)3.31047227
55negative thymic T cell selection (GO:0045060)3.29411089
56regulation of mast cell activation involved in immune response (GO:0033006)3.28691647
57response to protozoan (GO:0001562)3.24074449
58negative regulation of lymphocyte mediated immunity (GO:0002707)3.23963380
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.21728407
60cellular response to thyroid hormone stimulus (GO:0097067)3.18579924
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.18030261
62positive regulation of mast cell activation involved in immune response (GO:0033008)3.15612413
63positive regulation of mast cell degranulation (GO:0043306)3.15612413
64regulation of mast cell activation (GO:0033003)3.12648130
65regulation of interferon-alpha production (GO:0032647)3.12327661
66B cell receptor signaling pathway (GO:0050853)3.12291203
67leukocyte aggregation (GO:0070486)3.11764133
68regulation of T-helper 2 cell differentiation (GO:0045628)3.11283579
69positive regulation of cellular amide metabolic process (GO:0034250)3.10450925
70negative T cell selection (GO:0043383)3.09143243
71positive regulation of interferon-alpha production (GO:0032727)3.09127264
72type I interferon signaling pathway (GO:0060337)3.05469998
73cellular response to type I interferon (GO:0071357)3.05469998
74T-helper 1 type immune response (GO:0042088)3.05379201
75myeloid leukocyte mediated immunity (GO:0002444)3.05160918
76response to type I interferon (GO:0034340)3.04787097
77regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03994148
78interferon-gamma-mediated signaling pathway (GO:0060333)3.00690026
79regulation of B cell differentiation (GO:0045577)3.00451614
80positive thymic T cell selection (GO:0045059)2.98905260
81regulation of antigen processing and presentation (GO:0002577)2.96869438
82antigen processing and presentation of endogenous antigen (GO:0019883)2.94705774
83antigen processing and presentation via MHC class Ib (GO:0002475)2.94501080
84regulation of interleukin-8 biosynthetic process (GO:0045414)2.90087546
85positive regulation of type 2 immune response (GO:0002830)2.89981631
86positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.88919741
87regulation of B cell apoptotic process (GO:0002902)2.88427399
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.88392403
89positive regulation of antigen processing and presentation (GO:0002579)2.87233847
90JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.85570961
91regulation of leukocyte degranulation (GO:0043300)2.85183814
92hepatocyte apoptotic process (GO:0097284)2.84814710
93negative regulation of leukocyte mediated immunity (GO:0002704)2.80564681
94respiratory burst (GO:0045730)2.78585754
95positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78473695
96B cell mediated immunity (GO:0019724)2.78072754
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.76450774
98negative regulation of T-helper cell differentiation (GO:0045623)2.76450774
99production of molecular mediator involved in inflammatory response (GO:0002532)2.75975907
100positive regulation of interferon-beta production (GO:0032728)2.73779036

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.01879697
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.92339062
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.81866495
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.66492932
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.61570023
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.55203599
7SCL_19346495_ChIP-Seq_HPC-7_Human3.35614720
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.26370802
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.12264438
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.02789717
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.95625952
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.86884344
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.84040727
14VDR_21846776_ChIP-Seq_THP-1_Human2.80578560
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75615641
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67048488
17VDR_24763502_ChIP-Seq_THP-1_Human2.60518052
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52914427
19GATA1_22025678_ChIP-Seq_K562_Human2.42370132
20RUNX_20019798_ChIP-Seq_JUKART_Human2.42019444
21SPI1_23547873_ChIP-Seq_NB4_Human2.39506538
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.37221481
23MYB_26560356_Chip-Seq_TH2_Human2.32229230
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.31481682
25SPI1_23127762_ChIP-Seq_K562_Human2.31459770
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30258979
27MAF_26560356_Chip-Seq_TH1_Human2.28441585
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25201119
29GATA1_19941826_ChIP-Seq_K562_Human2.17875276
30MYC_22102868_ChIP-Seq_BL_Human2.13493469
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12491803
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.04037818
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03617098
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02481776
35BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02143684
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97670147
37MYB_26560356_Chip-Seq_TH1_Human1.96970874
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.94840629
39UTX_26944678_Chip-Seq_JUKART_Human1.92527190
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.92357050
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84933993
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.84209600
43VDR_24787735_ChIP-Seq_THP-1_Human1.83705368
44TCF7_22412390_ChIP-Seq_EML_Mouse1.77943414
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.71439283
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67243935
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64467835
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63717981
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.61736473
50MAF_26560356_Chip-Seq_TH2_Human1.59250484
51GATA3_27048872_Chip-Seq_THYMUS_Human1.57582096
52GATA2_19941826_ChIP-Seq_K562_Human1.54301115
53GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53034967
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51822720
55KDM2B_26808549_Chip-Seq_DND41_Human1.48979557
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48651286
57CIITA_25753668_ChIP-Seq_RAJI_Human1.44245421
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39254773
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39253395
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35877100
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34890778
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33270705
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32285895
64PU_27001747_Chip-Seq_BMDM_Mouse1.31250531
65GATA3_26560356_Chip-Seq_TH2_Human1.30619312
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30550664
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28255268
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26258925
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25847410
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25611219
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23978631
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23220493
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22419181
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21733778
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21381294
76TFEB_21752829_ChIP-Seq_HELA_Human1.20554109
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19827778
78NCOR1_26117541_ChIP-Seq_K562_Human1.19417551
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15258946
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.14874719
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14555514
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12921105
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12381938
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09955288
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09233088
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.07100609
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.04454715
88RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03738847
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02734221
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92138991
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.89804827
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89143705
93GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87741349
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85912202
95BCL6_27268052_Chip-Seq_Bcells_Human0.82828496
96BCOR_27268052_Chip-Seq_Bcells_Human0.79868959
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78517418
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.72874438
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.72573683
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72500739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.30899285
2MP0003436_decreased_susceptibility_to3.92188400
3MP0003724_increased_susceptibility_to3.78303897
4MP0001835_abnormal_antigen_presentation3.73907495
5MP0001545_abnormal_hematopoietic_system3.35141701
6MP0005397_hematopoietic_system_phenotyp3.35141701
7MP0000569_abnormal_digit_pigmentation3.14288310
8MP0003656_abnormal_erythrocyte_physiolo2.79539335
9MP0001800_abnormal_humoral_immune2.65852132
10MP0002419_abnormal_innate_immunity2.62610531
11MP0005000_abnormal_immune_tolerance2.57526575
12MP0006082_CNS_inflammation2.53351318
13MP0005025_abnormal_response_to2.49502151
14MP0000685_abnormal_immune_system2.46776392
15MP0009785_altered_susceptibility_to2.44993398
16MP0003172_abnormal_lysosome_physiology2.38503366
17MP0009278_abnormal_bone_marrow2.36903128
18MP0005671_abnormal_response_to2.36571139
19MP0002723_abnormal_immune_serum2.32557103
20MP0005387_immune_system_phenotype2.29496073
21MP0001790_abnormal_immune_system2.29496073
22MP0002132_abnormal_respiratory_system2.29169441
23MP0002452_abnormal_antigen_presenting2.25937532
24MP0005464_abnormal_platelet_physiology2.20920900
25MP0002148_abnormal_hypersensitivity_rea2.18890276
26MP0008260_abnormal_autophagy2.17578574
27MP0002420_abnormal_adaptive_immunity2.12660649
28MP0001819_abnormal_immune_cell2.11128846
29MP0003300_gastrointestinal_ulcer2.05434594
30MP0004947_skin_inflammation1.89755790
31MP0001533_abnormal_skeleton_physiology1.87916757
32MP0002398_abnormal_bone_marrow1.81090133
33MP0002396_abnormal_hematopoietic_system1.80970650
34MP0002166_altered_tumor_susceptibility1.78383082
35MP0005451_abnormal_body_composition1.77580072
36MP0003763_abnormal_thymus_physiology1.75902569
37MP0002405_respiratory_system_inflammati1.71497971
38MP0009764_decreased_sensitivity_to1.71448533
39MP0002332_abnormal_exercise_endurance1.68651152
40MP0001853_heart_inflammation1.67406188
41MP0000716_abnormal_immune_system1.67386858
42MP0000015_abnormal_ear_pigmentation1.64070450
43MP0000465_gastrointestinal_hemorrhage1.55851284
44MP0000689_abnormal_spleen_morphology1.50998096
45MP0004808_abnormal_hematopoietic_stem1.49289304
46MP0001845_abnormal_inflammatory_respons1.45879099
47MP0002722_abnormal_immune_system1.45568500
48MP0010155_abnormal_intestine_physiology1.42867689
49MP0002429_abnormal_blood_cell1.40516314
50MP0008004_abnormal_stomach_pH1.38612718
51MP0003191_abnormal_cellular_cholesterol1.36846177
52MP0008469_abnormal_protein_level1.33246252
53MP0003828_pulmonary_edema1.30206704
54MP0009333_abnormal_splenocyte_physiolog1.28124531
55MP0002006_tumorigenesis1.26496517
56MP0001873_stomach_inflammation1.23902388
57MP0002009_preneoplasia1.21053901
58MP0005058_abnormal_lysosome_morphology1.20831956
59MP0003075_altered_response_to1.20096264
60MP0003045_fibrosis1.15804133
61MP0004883_abnormal_blood_vessel1.14470802
62MP0002998_abnormal_bone_remodeling1.13686954
63MP0005174_abnormal_tail_pigmentation1.09567064
64MP0000703_abnormal_thymus_morphology1.09304442
65MP0005310_abnormal_salivary_gland1.07788049
66MP0009763_increased_sensitivity_to1.04884772
67MP0004510_myositis1.04648797
68MP0009765_abnormal_xenobiotic_induced1.03180353
69MP0003690_abnormal_glial_cell1.00963158
70MP0005083_abnormal_biliary_tract1.00185737
71MP0005164_abnormal_response_to0.96058118
72MP0000858_altered_metastatic_potential0.95010935
73MP0001851_eye_inflammation0.90932329
74MP0004381_abnormal_hair_follicle0.89095749
75MP0005076_abnormal_cell_differentiation0.88991510
76MP0005075_abnormal_melanosome_morpholog0.87371691
77MP0000343_altered_response_to0.84916161
78MP0005166_decreased_susceptibility_to0.83833091
79MP0003448_altered_tumor_morphology0.79326835
80MP0003091_abnormal_cell_migration0.77878302
81MP0003866_abnormal_defecation0.76543886
82MP0001663_abnormal_digestive_system0.74988514
83MP0005666_abnormal_adipose_tissue0.71240675
84MP0000371_diluted_coat_color0.70283456
85MP0003453_abnormal_keratinocyte_physiol0.67359319
86MP0005390_skeleton_phenotype0.67316808
87MP0000249_abnormal_blood_vessel0.65190304
88MP0005376_homeostasis/metabolism_phenot0.62220308
89MP0009115_abnormal_fat_cell0.62017265
90MP0000604_amyloidosis0.61108818
91MP0002019_abnormal_tumor_incidence0.60816803
92MP0004130_abnormal_muscle_cell0.60558939
93MP0001986_abnormal_taste_sensitivity0.59526693
94MP0003795_abnormal_bone_structure0.59214835
95MP0005266_abnormal_metabolism0.58166407
96MP0008874_decreased_physiological_sensi0.58097140
97MP0002933_joint_inflammation0.54903866
98MP0009840_abnormal_foam_cell0.54821338
99MP0000609_abnormal_liver_physiology0.54601453
100MP0005334_abnormal_fat_pad0.53814645

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.51441126
2Retrobulbar optic neuritis (HP:0100654)5.01174369
3Optic neuritis (HP:0100653)5.01174369
4Recurrent abscess formation (HP:0002722)5.00740141
5Myositis (HP:0100614)4.83553399
6Eczematoid dermatitis (HP:0000976)4.80415528
7Orchitis (HP:0100796)4.80176393
8Abnormality of macrophages (HP:0004311)4.27883689
9Recurrent fungal infections (HP:0002841)4.14757869
10Petechiae (HP:0000967)4.00421656
11Prolonged bleeding time (HP:0003010)3.97244232
12Mediastinal lymphadenopathy (HP:0100721)3.95693967
13Elevated erythrocyte sedimentation rate (HP:0003565)3.87131496
14Stomatitis (HP:0010280)3.81602689
15Gastrointestinal infarctions (HP:0005244)3.72011301
16Recurrent viral infections (HP:0004429)3.71534989
17Recurrent skin infections (HP:0001581)3.66421723
18Keratoconjunctivitis sicca (HP:0001097)3.64553635
19Recurrent cutaneous fungal infections (HP:0011370)3.64335729
20Chronic mucocutaneous candidiasis (HP:0002728)3.64335729
21Recurrent gram-negative bacterial infections (HP:0005420)3.47035806
22Increased serum ferritin (HP:0003281)3.45967667
23Epistaxis (HP:0000421)3.43688276
24Encephalitis (HP:0002383)3.36774115
25Keratoconjunctivitis (HP:0001096)3.31244688
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.28727053
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.28716977
28Arterial thrombosis (HP:0004420)3.26225520
29Meningitis (HP:0001287)3.24143629
30T lymphocytopenia (HP:0005403)3.22492376
31Gingival bleeding (HP:0000225)3.11050008
32Autoimmune thrombocytopenia (HP:0001973)3.08865696
33Impaired platelet aggregation (HP:0003540)3.08616889
34Abnormal platelet function (HP:0011869)3.08616889
35Abnormality of T cell number (HP:0011839)3.08385332
36Gingivitis (HP:0000230)3.01114251
37Hemoptysis (HP:0002105)2.99786715
38Abnormality of the heme biosynthetic pathway (HP:0010472)2.95187720
39Vasculitis (HP:0002633)2.92987789
40Pulmonary infiltrates (HP:0002113)2.87385372
41Leukocytosis (HP:0001974)2.84242195
42Colitis (HP:0002583)2.79585353
43Polycythemia (HP:0001901)2.76524895
44Chest pain (HP:0100749)2.76384465
45Abnormality of iron homeostasis (HP:0011031)2.76081890
46Abnormality of the fingertips (HP:0001211)2.75827456
47Amyloidosis (HP:0011034)2.75689723
48Panhypogammaglobulinemia (HP:0003139)2.74330531
49Obstructive lung disease (HP:0006536)2.68739465
50Chronic obstructive pulmonary disease (HP:0006510)2.68739465
51Abnormality of T cells (HP:0002843)2.63605639
52Loss of speech (HP:0002371)2.62478579
53Increased IgM level (HP:0003496)2.60852837
54Granulocytopenia (HP:0001913)2.60200912
55Autoimmune hemolytic anemia (HP:0001890)2.59237753
56Urticaria (HP:0001025)2.58433127
57Cellulitis (HP:0100658)2.52422435
58Abnormality of glycolipid metabolism (HP:0010969)2.48173192
59Abnormality of liposaccharide metabolism (HP:0010968)2.48173192
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.48173192
61Increased IgE level (HP:0003212)2.46548220
62Episodic fever (HP:0001954)2.46362473
63Vertigo (HP:0002321)2.42921440
64Alveolar cell carcinoma (HP:0006519)2.41786809
65Pustule (HP:0200039)2.40989525
66Neoplasm of the tracheobronchial system (HP:0100552)2.39685352
67Anorexia (HP:0002039)2.39555206
68Abnormality of the pleura (HP:0002103)2.36192421
69Abnormality of transition element cation homeostasis (HP:0011030)2.35608852
70Dry hair (HP:0011359)2.34958207
71Inflammation of the large intestine (HP:0002037)2.34749506
72Gangrene (HP:0100758)2.34535390
73Agammaglobulinemia (HP:0004432)2.29702449
74Neurodegeneration (HP:0002180)2.29151051
75Gastrointestinal inflammation (HP:0004386)2.25725782
76Osteomyelitis (HP:0002754)2.25627101
77Spontaneous hematomas (HP:0007420)2.23021175
78Acanthocytosis (HP:0001927)2.20994745
79Reticulocytosis (HP:0001923)2.18137256
80Peritonitis (HP:0002586)2.17313309
81Polyneuropathy (HP:0001271)2.16770182
82Viral hepatitis (HP:0006562)2.16241545
83Abnormality of T cell physiology (HP:0011840)2.15553784
84Amaurosis fugax (HP:0100576)2.15082496
85Anhidrosis (HP:0000970)2.14933422
86Eosinophilia (HP:0001880)2.13824297
87Poikilocytosis (HP:0004447)2.12068920
88Albinism (HP:0001022)2.12050465
89Fatigue (HP:0012378)2.09456905
90Abnormality of the peritoneum (HP:0002585)2.09123123
91Acute hepatic failure (HP:0006554)2.03675281
92Hematochezia (HP:0002573)2.02510924
93Pulmonary embolism (HP:0002204)2.02102715
94Chronic otitis media (HP:0000389)1.97493234
95Joint swelling (HP:0001386)1.96888830
96Abnormality of the endocardium (HP:0004306)1.95588918
97Glomerulopathy (HP:0100820)1.94888718
98Increased cerebral lipofuscin (HP:0011813)1.94566039
99Global brain atrophy (HP:0002283)1.93191398
100Keratitis (HP:0000491)1.91068238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.59169002
2RIPK43.58797880
3MAP4K12.98826541
4PRPF4B2.97052578
5TYK22.66543992
6MAP2K32.64505182
7TXK2.40869999
8IKBKE2.33785896
9BMPR22.00792673
10IRAK41.97220365
11ZAP701.96719794
12JAK11.91224781
13PIK3CG1.84416695
14ERN11.81447402
15MAP3K131.81372128
16JAK31.79493656
17CSK1.78098769
18MAP3K141.74724062
19PIM21.74198609
20IKBKB1.69207750
21BTK1.68691815
22SYK1.67858900
23FES1.67847310
24JAK21.66625497
25TAOK21.55320452
26RAF11.53428373
27TBK11.49618781
28GRK61.48795940
29MAP3K31.36446034
30SCYL21.36189554
31KIT1.34840108
32IRAK31.32183368
33TAOK31.30677558
34HCK1.28170468
35LYN1.22796803
36TEC1.17786179
37TESK21.16233585
38MAP3K11.14235606
39PIM11.13960387
40MATK1.12810890
41ITK1.11431648
42IRAK11.11184627
43FGR1.10376306
44TAOK11.09838304
45LCK1.08242514
46MAP3K111.07809065
47MAP3K61.07705866
48GRK71.00939262
49NME20.97611816
50PKN10.96682658
51IRAK20.93399825
52TNK20.91052396
53CDK190.90868942
54MARK20.88999036
55MARK30.88284587
56RIPK10.85729153
57TGFBR20.84043195
58CSF1R0.83642171
59EPHB10.77774866
60CHUK0.77530432
61MOS0.77494279
62KSR20.74882033
63CDK120.73981683
64MAPK70.73780003
65MAPK110.73623608
66SGK20.72501812
67AKT30.71058639
68BRD40.70355074
69STK100.67796807
70PDK10.67106160
71SGK30.62492543
72KDR0.61710833
73CDC42BPA0.60756879
74MAP3K50.59143131
75FGFR30.58585299
76CLK10.55323532
77EPHA30.54843974
78ERBB20.54506446
79PDPK10.53134407
80MAPK120.52487255
81RPS6KL10.52481871
82RPS6KC10.52481871
83STK40.50888254
84TRIB30.50603765
85MAP3K70.50368626
86STK160.50194078
87CDK40.49781980
88RPS6KA60.46994911
89FGFR40.46862714
90PRKD10.45539752
91MAPK30.45186688
92TRPM70.44651127
93YES10.44332602
94WNK10.44113994
95PRKD20.42313322
96TTN0.39973811
97RET0.37977027
98CAMK1D0.37951135
99KSR10.35768456
100ABL10.33349361

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.17171420
2Osteoclast differentiation_Homo sapiens_hsa043802.76079251
3Allograft rejection_Homo sapiens_hsa053302.51247402
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.49641326
5Staphylococcus aureus infection_Homo sapiens_hsa051502.33832787
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.28997363
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28496884
8Asthma_Homo sapiens_hsa053102.22979498
9Autoimmune thyroid disease_Homo sapiens_hsa053202.16816590
10B cell receptor signaling pathway_Homo sapiens_hsa046622.16122389
11Tuberculosis_Homo sapiens_hsa051522.14906475
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.14019643
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.11271032
14Graft-versus-host disease_Homo sapiens_hsa053322.08255189
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.01081966
16Influenza A_Homo sapiens_hsa051641.90875190
17Measles_Homo sapiens_hsa051621.86346252
18Malaria_Homo sapiens_hsa051441.81232087
19Acute myeloid leukemia_Homo sapiens_hsa052211.78385734
20Legionellosis_Homo sapiens_hsa051341.77482347
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74655194
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73577347
23Toxoplasmosis_Homo sapiens_hsa051451.72701675
24TNF signaling pathway_Homo sapiens_hsa046681.68497488
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.64016583
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.59945090
27Herpes simplex infection_Homo sapiens_hsa051681.59916559
28Other glycan degradation_Homo sapiens_hsa005111.56581702
29Primary immunodeficiency_Homo sapiens_hsa053401.56312886
30Type I diabetes mellitus_Homo sapiens_hsa049401.52726512
31T cell receptor signaling pathway_Homo sapiens_hsa046601.46249920
32Hematopoietic cell lineage_Homo sapiens_hsa046401.45073416
33Rheumatoid arthritis_Homo sapiens_hsa053231.42648572
34Hepatitis B_Homo sapiens_hsa051611.42306142
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40186574
36African trypanosomiasis_Homo sapiens_hsa051431.40108421
37Non-small cell lung cancer_Homo sapiens_hsa052231.39911015
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.37672808
39Antigen processing and presentation_Homo sapiens_hsa046121.36157472
40Pertussis_Homo sapiens_hsa051331.31646641
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31057346
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24952535
43Chemokine signaling pathway_Homo sapiens_hsa040621.22933150
44Hepatitis C_Homo sapiens_hsa051601.15214895
45Platelet activation_Homo sapiens_hsa046111.14556462
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13523348
47Viral myocarditis_Homo sapiens_hsa054161.09057924
48Bladder cancer_Homo sapiens_hsa052191.02039240
49Prolactin signaling pathway_Homo sapiens_hsa049171.01205456
50Salmonella infection_Homo sapiens_hsa051320.96841638
51Pancreatic cancer_Homo sapiens_hsa052120.96406588
52Chronic myeloid leukemia_Homo sapiens_hsa052200.91890504
53Apoptosis_Homo sapiens_hsa042100.91242940
54Dorso-ventral axis formation_Homo sapiens_hsa043200.90973311
55Lysosome_Homo sapiens_hsa041420.88639437
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88293312
57Epstein-Barr virus infection_Homo sapiens_hsa051690.87577580
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84264165
59Phagosome_Homo sapiens_hsa041450.83603582
60mTOR signaling pathway_Homo sapiens_hsa041500.81313176
61VEGF signaling pathway_Homo sapiens_hsa043700.77039398
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.76879740
63Shigellosis_Homo sapiens_hsa051310.75049099
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74812176
65FoxO signaling pathway_Homo sapiens_hsa040680.73347289
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70483156
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70258271
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.69445256
69Type II diabetes mellitus_Homo sapiens_hsa049300.69311752
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67971111
71HIF-1 signaling pathway_Homo sapiens_hsa040660.67329939
72Endometrial cancer_Homo sapiens_hsa052130.64050011
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.62971791
74Renal cell carcinoma_Homo sapiens_hsa052110.59689215
75Regulation of autophagy_Homo sapiens_hsa041400.58188479
76Amoebiasis_Homo sapiens_hsa051460.54612145
77Viral carcinogenesis_Homo sapiens_hsa052030.52951506
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.52794713
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52531368
80ErbB signaling pathway_Homo sapiens_hsa040120.52434764
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52276463
82HTLV-I infection_Homo sapiens_hsa051660.52036757
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47894036
84Notch signaling pathway_Homo sapiens_hsa043300.47776225
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.46673322
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46438674
87Choline metabolism in cancer_Homo sapiens_hsa052310.45928207
88Insulin resistance_Homo sapiens_hsa049310.43990389
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42687309
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39615824
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38163420
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.37508522
93Small cell lung cancer_Homo sapiens_hsa052220.37165906
94GnRH signaling pathway_Homo sapiens_hsa049120.36275289
95Inositol phosphate metabolism_Homo sapiens_hsa005620.36150779
96Endocytosis_Homo sapiens_hsa041440.35015554
97MAPK signaling pathway_Homo sapiens_hsa040100.34990842
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34473217
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32115347
100Prostate cancer_Homo sapiens_hsa052150.30293350

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