TCF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.48055695
2presynaptic membrane assembly (GO:0097105)5.25310938
3presynaptic membrane organization (GO:0097090)4.90768782
4vocalization behavior (GO:0071625)4.79250410
5pyrimidine nucleobase catabolic process (GO:0006208)4.76891547
6cerebral cortex radially oriented cell migration (GO:0021799)4.61740910
7ionotropic glutamate receptor signaling pathway (GO:0035235)4.57071157
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.50724946
9neuron recognition (GO:0008038)4.47267739
10cardiac ventricle formation (GO:0003211)4.41515757
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.19455808
12axonal fasciculation (GO:0007413)4.17923588
13glutamate receptor signaling pathway (GO:0007215)4.17231626
14protein localization to synapse (GO:0035418)4.03552881
15cardiac chamber formation (GO:0003207)4.03541436
16negative regulation of synaptic transmission, GABAergic (GO:0032229)4.03299265
17cerebellar granule cell differentiation (GO:0021707)4.01387394
18neural tube formation (GO:0001841)3.98281663
19glial cell proliferation (GO:0014009)3.96016336
20regulation of glutamate receptor signaling pathway (GO:1900449)3.91857844
21regulation of sarcomere organization (GO:0060297)3.91360172
22postsynaptic membrane organization (GO:0001941)3.87849059
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85781981
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.85404105
25central nervous system projection neuron axonogenesis (GO:0021952)3.80606349
26regulation of pigment cell differentiation (GO:0050932)3.78917519
27synaptic transmission, glutamatergic (GO:0035249)3.77239693
28limb bud formation (GO:0060174)3.74127597
29nucleobase catabolic process (GO:0046113)3.70066319
30locomotory exploration behavior (GO:0035641)3.68070430
31negative regulation of neurotransmitter transport (GO:0051589)3.61444036
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.61295881
33neurotransmitter-gated ion channel clustering (GO:0072578)3.59996334
34sympathetic nervous system development (GO:0048485)3.59898507
35startle response (GO:0001964)3.59677272
36neuron-neuron synaptic transmission (GO:0007270)3.58750178
37transmission of nerve impulse (GO:0019226)3.58187138
38positive regulation of developmental pigmentation (GO:0048087)3.56693939
39synaptic vesicle exocytosis (GO:0016079)3.53933125
40positive regulation of synapse maturation (GO:0090129)3.53092129
41auditory behavior (GO:0031223)3.50025598
42mechanosensory behavior (GO:0007638)3.49816654
43axon ensheathment in central nervous system (GO:0032291)3.48528390
44central nervous system myelination (GO:0022010)3.48528390
45negative regulation of neurotransmitter secretion (GO:0046929)3.45257208
46negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.42223286
47regulation of dendritic spine morphogenesis (GO:0061001)3.40883470
48layer formation in cerebral cortex (GO:0021819)3.39962864
49dendritic spine morphogenesis (GO:0060997)3.39954996
50positive regulation of synapse assembly (GO:0051965)3.39537963
51neuronal action potential propagation (GO:0019227)3.38596310
52gamma-aminobutyric acid transport (GO:0015812)3.35359538
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.33186276
54regulation of synapse maturation (GO:0090128)3.28169928
55somite development (GO:0061053)3.27013085
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.26601069
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25561771
58dendrite morphogenesis (GO:0048813)3.23926841
59central nervous system neuron axonogenesis (GO:0021955)3.21235350
60exploration behavior (GO:0035640)3.20688446
61spinal cord development (GO:0021510)3.19842311
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16317942
63regulation of dendritic spine development (GO:0060998)3.12235507
64cell migration in hindbrain (GO:0021535)3.11601777
65regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10933082
66long-term synaptic potentiation (GO:0060291)3.09804173
67behavioral response to ethanol (GO:0048149)3.07239563
68regulation of synaptic vesicle exocytosis (GO:2000300)3.05505454
69regulation of postsynaptic membrane potential (GO:0060078)3.04804278
70epithelial cell differentiation involved in kidney development (GO:0035850)3.02670318
71long-term memory (GO:0007616)3.00714038
72regulation of neuronal synaptic plasticity (GO:0048168)3.00235970
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99452825
74regulation of synapse assembly (GO:0051963)2.98032645
75glutamate secretion (GO:0014047)2.97060804
76regulation of synaptic transmission, glutamatergic (GO:0051966)2.95947465
77positive regulation of action potential (GO:0045760)2.95221441
78glycosphingolipid biosynthetic process (GO:0006688)2.95170448
79positive regulation of cardiac muscle cell differentiation (GO:2000727)2.94561447
80synapse assembly (GO:0007416)2.93031597
81calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.92286916
82membrane assembly (GO:0071709)2.90829030
83positive regulation of dendritic spine morphogenesis (GO:0061003)2.90493824
84C4-dicarboxylate transport (GO:0015740)2.90181948
85lymphangiogenesis (GO:0001946)2.89825070
86positive regulation of membrane potential (GO:0045838)2.87051995
87cerebral cortex cell migration (GO:0021795)2.86095003
88negative regulation of axon extension (GO:0030517)2.85820618
89establishment of mitochondrion localization (GO:0051654)2.84883972
90dendrite development (GO:0016358)2.84055395
91neuron remodeling (GO:0016322)2.82118323
92positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80936912
93learning (GO:0007612)2.80550665
94olfactory bulb development (GO:0021772)2.80222904
95negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79298014
96negative regulation of translation, ncRNA-mediated (GO:0040033)2.79298014
97regulation of translation, ncRNA-mediated (GO:0045974)2.79298014
98adult walking behavior (GO:0007628)2.79245122
99positive regulation of dendritic spine development (GO:0060999)2.78363337
100regulation of synaptic plasticity (GO:0048167)2.78297454
101forebrain neuron differentiation (GO:0021879)2.76864958
102protein K11-linked deubiquitination (GO:0035871)2.76542638
103regulation of synaptic transmission, GABAergic (GO:0032228)2.76177929
104negative regulation of dendrite development (GO:2000171)2.75169795
105negative regulation of protein localization to cell surface (GO:2000009)2.74207933
106atrial cardiac muscle cell action potential (GO:0086014)2.73982292
107negative regulation of axonogenesis (GO:0050771)2.73572753
108L-amino acid import (GO:0043092)2.73465935
109membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72784358
110regulation of penile erection (GO:0060405)2.72278762
111inner ear receptor stereocilium organization (GO:0060122)2.71722153
112regulation of respiratory system process (GO:0044065)2.71525456
113neurotransmitter secretion (GO:0007269)2.71175412
114behavioral defense response (GO:0002209)2.70443000
115behavioral fear response (GO:0001662)2.70443000
116neuronal ion channel clustering (GO:0045161)2.69823958
117regulation of synaptic vesicle transport (GO:1902803)2.69363443
118apical protein localization (GO:0045176)2.68738349
119regulation of synapse organization (GO:0050807)2.68388503
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.67751807
121synaptic vesicle endocytosis (GO:0048488)2.67270149
122dentate gyrus development (GO:0021542)2.67161478
123regulation of axon extension involved in axon guidance (GO:0048841)2.66797912
124negative regulation of synaptic transmission (GO:0050805)2.66108487
125synapse organization (GO:0050808)2.65797282
126oligodendrocyte differentiation (GO:0048709)2.65684796
127serotonin receptor signaling pathway (GO:0007210)2.65524011
128dendritic spine organization (GO:0097061)2.64689003
129long-chain fatty acid biosynthetic process (GO:0042759)2.62270929
130amino acid import (GO:0043090)2.60883534
131myelination (GO:0042552)2.60457063
132hippocampus development (GO:0021766)2.57654401
133positive regulation of amino acid transport (GO:0051957)2.57449798
134fear response (GO:0042596)2.57218873
135membrane depolarization (GO:0051899)2.56850515
136positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.56606560
137cell morphogenesis involved in neuron differentiation (GO:0048667)2.55994002
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55310831
139heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.54274055
140regulation of dendrite morphogenesis (GO:0048814)2.53959208
141regulation of axon guidance (GO:1902667)2.53842011
142regulation of development, heterochronic (GO:0040034)2.53725484
143head development (GO:0060322)2.53515273
144regulation of timing of cell differentiation (GO:0048505)2.53349898
145negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52807035
146retinal cone cell development (GO:0046549)2.52595779
147kidney morphogenesis (GO:0060993)2.51098092
148synaptic vesicle maturation (GO:0016188)2.48739349
149response to auditory stimulus (GO:0010996)2.46642970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.27030667
2GBX2_23144817_ChIP-Seq_PC3_Human4.12777439
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94953709
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88627961
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77952898
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.59084817
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.56242898
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49660984
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49388407
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49388407
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.49137199
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47749048
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44050262
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35053220
15TAF15_26573619_Chip-Seq_HEK293_Human2.22494314
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17478330
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13555570
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.09620172
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02189118
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.01507902
21AR_21572438_ChIP-Seq_LNCaP_Human1.99666102
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97408063
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.96935436
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.96387367
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95517711
26* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93647529
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92131511
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91302911
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90240782
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88143595
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.87941232
32P300_19829295_ChIP-Seq_ESCs_Human1.83210896
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81870917
34* REST_21632747_ChIP-Seq_MESCs_Mouse1.77036721
35* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76760329
36FUS_26573619_Chip-Seq_HEK293_Human1.76430832
37DROSHA_22980978_ChIP-Seq_HELA_Human1.75487398
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74862805
39SMAD4_21799915_ChIP-Seq_A2780_Human1.74794427
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.74766979
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74250407
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74003339
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.67830440
44* SMAD3_21741376_ChIP-Seq_EPCs_Human1.64477876
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57052286
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50145999
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49776240
48* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46207333
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.44805723
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.44746869
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44369839
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42303414
53IGF1R_20145208_ChIP-Seq_DFB_Human1.41551682
54ER_23166858_ChIP-Seq_MCF-7_Human1.39615225
55ZNF274_21170338_ChIP-Seq_K562_Hela1.37853001
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36562159
57VDR_22108803_ChIP-Seq_LS180_Human1.36308167
58CBP_20019798_ChIP-Seq_JUKART_Human1.34515157
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34515157
60AR_25329375_ChIP-Seq_VCAP_Human1.34247493
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33940211
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33262481
63RNF2_27304074_Chip-Seq_NSC_Mouse1.33038368
64STAT3_23295773_ChIP-Seq_U87_Human1.32169529
65TP53_18474530_ChIP-ChIP_U2OS_Human1.31374672
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.30989047
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.28831747
68TP53_16413492_ChIP-PET_HCT116_Human1.28722592
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27371409
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26781268
71LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26262819
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25417302
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24994951
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24094035
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24094035
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.23620581
77* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23318839
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.22963073
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.22871039
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.22581152
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22564461
82TCF4_23295773_ChIP-Seq_U87_Human1.21397661
83* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21241867
84AHR_22903824_ChIP-Seq_MCF-7_Human1.21136547
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.20839952
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19878498
87KDM2B_26808549_Chip-Seq_REH_Human1.19422669
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19412199
89RUNX2_22187159_ChIP-Seq_PCA_Human1.18154042
90* SOX9_26525672_Chip-Seq_HEART_Mouse1.15363717
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14073910
92* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13410650
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.12581516
94* TCF4_22108803_ChIP-Seq_LS180_Human1.11762996
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11743899
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11283415
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.10196365
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10066294
99EWS_26573619_Chip-Seq_HEK293_Human1.09760413
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09696756
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09438144
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08796519
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08076835
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07276959
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.06983783
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06498084
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.06408064
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05685765
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04393553
110AR_19668381_ChIP-Seq_PC3_Human1.03247686
111BCAT_22108803_ChIP-Seq_LS180_Human1.02879310
112* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01632722
113* WT1_19549856_ChIP-ChIP_CCG9911_Human1.01534330
114P53_22387025_ChIP-Seq_ESCs_Mouse1.01120584
115* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00543886
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.00356922
117IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99916163
118P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99860219
119* JUN_21703547_ChIP-Seq_K562_Human0.99726353
120* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99336049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.74306516
2MP0004859_abnormal_synaptic_plasticity4.66886504
3MP0003635_abnormal_synaptic_transmissio3.24587924
4MP0004270_analgesia3.08159856
5MP0009745_abnormal_behavioral_response2.85557570
6MP0000778_abnormal_nervous_system2.82413277
7MP0002064_seizures2.70096377
8MP0002063_abnormal_learning/memory/cond2.68992352
9MP0001486_abnormal_startle_reflex2.46106164
10MP0002572_abnormal_emotion/affect_behav2.38105821
11MP0009046_muscle_twitch2.36655137
12MP0002735_abnormal_chemical_nociception2.32135660
13MP0002272_abnormal_nervous_system2.26850285
14MP0001188_hyperpigmentation2.26525431
15MP0005423_abnormal_somatic_nervous2.19827970
16MP0005171_absent_coat_pigmentation2.15813297
17MP0003787_abnormal_imprinting2.06959838
18MP0001968_abnormal_touch/_nociception2.01660903
19MP0002734_abnormal_mechanical_nocicepti1.99480291
20MP0002751_abnormal_autonomic_nervous1.90607879
21MP0004885_abnormal_endolymph1.89937387
22MP0002184_abnormal_innervation1.89573803
23MP0000569_abnormal_digit_pigmentation1.83102309
24MP0002067_abnormal_sensory_capabilities1.82767503
25MP0002638_abnormal_pupillary_reflex1.79497883
26MP0002736_abnormal_nociception_after1.79314056
27MP0006292_abnormal_olfactory_placode1.74558996
28MP0001440_abnormal_grooming_behavior1.72195691
29MP0005187_abnormal_penis_morphology1.64670438
30MP0001501_abnormal_sleep_pattern1.61574759
31MP0010368_abnormal_lymphatic_system1.60607494
32MP0002557_abnormal_social/conspecific_i1.59006585
33MP0005409_darkened_coat_color1.57455111
34MP0001986_abnormal_taste_sensitivity1.56315874
35MP0000955_abnormal_spinal_cord1.53341779
36MP0009780_abnormal_chondrocyte_physiolo1.53215879
37MP0008877_abnormal_DNA_methylation1.51340863
38MP0002822_catalepsy1.49839140
39MP0000516_abnormal_urinary_system1.49400002
40MP0005367_renal/urinary_system_phenotyp1.49400002
41MP0000920_abnormal_myelination1.49217744
42MP0004742_abnormal_vestibular_system1.48127834
43MP0006072_abnormal_retinal_apoptosis1.46698189
44MP0002882_abnormal_neuron_morphology1.45705105
45MP0008569_lethality_at_weaning1.41080782
46MP0004924_abnormal_behavior1.39837446
47MP0005386_behavior/neurological_phenoty1.39837446
48MP0005646_abnormal_pituitary_gland1.39500317
49MP0006276_abnormal_autonomic_nervous1.38655894
50MP0000537_abnormal_urethra_morphology1.38516465
51MP0003938_abnormal_ear_development1.37632658
52MP0001984_abnormal_olfaction1.36072449
53MP0001970_abnormal_pain_threshold1.35869150
54MP0005253_abnormal_eye_physiology1.35689787
55MP0002733_abnormal_thermal_nociception1.30899503
56MP0004811_abnormal_neuron_physiology1.29333738
57MP0003136_yellow_coat_color1.25559183
58MP0000049_abnormal_middle_ear1.24629377
59MP0002066_abnormal_motor_capabilities/c1.24186784
60MP0000631_abnormal_neuroendocrine_gland1.21611595
61* MP0002152_abnormal_brain_morphology1.20032884
62MP0001905_abnormal_dopamine_level1.20007602
63MP0005645_abnormal_hypothalamus_physiol1.17535007
64MP0003935_abnormal_craniofacial_develop1.17292282
65MP0003329_amyloid_beta_deposits1.16972041
66MP0001963_abnormal_hearing_physiology1.16081021
67MP0004134_abnormal_chest_morphology1.15220776
68MP0001529_abnormal_vocalization1.14583756
69MP0001177_atelectasis1.12846598
70MP0001485_abnormal_pinna_reflex1.10629690
71MP0000026_abnormal_inner_ear1.10457957
72MP0003634_abnormal_glial_cell1.09836912
73MP0010386_abnormal_urinary_bladder1.07874317
74MP0004142_abnormal_muscle_tone1.06947965
75MP0004858_abnormal_nervous_system1.06678852
76MP0001502_abnormal_circadian_rhythm1.05961644
77MP0002752_abnormal_somatic_nervous1.03989365
78MP0001299_abnormal_eye_distance/1.03703912
79MP0005499_abnormal_olfactory_system1.03398997
80MP0005394_taste/olfaction_phenotype1.03398997
81MP0005551_abnormal_eye_electrophysiolog1.02167396
82MP0003385_abnormal_body_wall1.00951529
83MP0002837_dystrophic_cardiac_calcinosis0.98617849
84MP0004043_abnormal_pH_regulation0.98339676
85MP0003632_abnormal_nervous_system0.98251713
86MP0003119_abnormal_digestive_system0.95695128
87MP0003631_nervous_system_phenotype0.94784481
88* MP0003861_abnormal_nervous_system0.94335895
89MP0001270_distended_abdomen0.93523867
90MP0003755_abnormal_palate_morphology0.92681902
91MP0003122_maternal_imprinting0.92158727
92MP0009250_abnormal_appendicular_skeleto0.91100561
93MP0003633_abnormal_nervous_system0.91042150
94MP0003690_abnormal_glial_cell0.90554697
95MP0008789_abnormal_olfactory_epithelium0.90014438
96MP0000534_abnormal_ureter_morphology0.89931612
97MP0004085_abnormal_heartbeat0.87393835
98MP0000566_synostosis0.87079101
99MP0002653_abnormal_ependyma_morphology0.86286662
100MP0002229_neurodegeneration0.84976835
101MP0004145_abnormal_muscle_electrophysio0.84444798
102MP0009379_abnormal_foot_pigmentation0.84105562
103MP0005195_abnormal_posterior_eye0.83279646
104MP0000015_abnormal_ear_pigmentation0.81724374
105MP0004484_altered_response_of0.80955232
106MP0000647_abnormal_sebaceous_gland0.80222986
107MP0003137_abnormal_impulse_conducting0.78665025
108* MP0002081_perinatal_lethality0.78136238
109MP0001943_abnormal_respiration0.76881681
110MP0005391_vision/eye_phenotype0.76873744
111MP0004215_abnormal_myocardial_fiber0.76246331
112MP0003937_abnormal_limbs/digits/tail_de0.76231004
113MP0000383_abnormal_hair_follicle0.74887102
114MP0002102_abnormal_ear_morphology0.73949258
115MP0005167_abnormal_blood-brain_barrier0.73001855
116MP0008058_abnormal_DNA_repair0.72956094
117MP0002234_abnormal_pharynx_morphology0.72940633
118MP0002233_abnormal_nose_morphology0.71986493
119MP0000751_myopathy0.71499610
120MP0003121_genomic_imprinting0.71452855
121MP0001879_abnormal_lymphatic_vessel0.71122265
122MP0009384_cardiac_valve_regurgitation0.69338662
123MP0002249_abnormal_larynx_morphology0.69083821
124MP0002069_abnormal_eating/drinking_beha0.68688690

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.35164960
2Epileptic encephalopathy (HP:0200134)4.36444730
3Atonic seizures (HP:0010819)4.25743915
4Focal seizures (HP:0007359)3.98988046
5Febrile seizures (HP:0002373)3.80621403
6Broad-based gait (HP:0002136)3.66162595
7Excessive salivation (HP:0003781)3.35190034
8Drooling (HP:0002307)3.35190034
9Progressive cerebellar ataxia (HP:0002073)3.11786564
10Degeneration of the lateral corticospinal tracts (HP:0002314)2.89528025
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.89528025
12Neurofibrillary tangles (HP:0002185)2.88813371
13Absence seizures (HP:0002121)2.87649979
14Abnormality of the labia minora (HP:0012880)2.87456550
15Hepatoblastoma (HP:0002884)2.86755608
16Dialeptic seizures (HP:0011146)2.81908176
17Myokymia (HP:0002411)2.79549370
18Amblyopia (HP:0000646)2.77810224
19* Hyperventilation (HP:0002883)2.73027427
20Protruding tongue (HP:0010808)2.71644785
21True hermaphroditism (HP:0010459)2.71447008
22Large earlobe (HP:0009748)2.71441734
23Aqueductal stenosis (HP:0002410)2.70751917
24Volvulus (HP:0002580)2.63083910
25Progressive inability to walk (HP:0002505)2.62910639
26Colon cancer (HP:0003003)2.60389757
27Tented upper lip vermilion (HP:0010804)2.58785470
28Gaze-evoked nystagmus (HP:0000640)2.57870310
29Short 4th metacarpal (HP:0010044)2.56964264
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.56964264
31Pancreatic cysts (HP:0001737)2.55180761
32Oligodactyly (hands) (HP:0001180)2.54954205
33Abnormality of the corticospinal tract (HP:0002492)2.54660777
34Cerebral inclusion bodies (HP:0100314)2.54176145
35Chin dimple (HP:0010751)2.49133854
36Lissencephaly (HP:0001339)2.48554700
37Pancreatic fibrosis (HP:0100732)2.45408328
38Pachygyria (HP:0001302)2.42438294
39Nephronophthisis (HP:0000090)2.41114469
40Abnormality of salivation (HP:0100755)2.37996270
41Abnormality of midbrain morphology (HP:0002418)2.31110727
42Molar tooth sign on MRI (HP:0002419)2.31110727
43Stomach cancer (HP:0012126)2.31064135
44Generalized tonic-clonic seizures (HP:0002069)2.28661070
45Neoplasm of the oral cavity (HP:0100649)2.28184756
46Inability to walk (HP:0002540)2.26425043
47Megalencephaly (HP:0001355)2.25707681
48Submucous cleft hard palate (HP:0000176)2.25618470
49Exotropia (HP:0000577)2.25492752
50Blue irides (HP:0000635)2.25447392
51* Absent speech (HP:0001344)2.25254450
52Renal hypoplasia (HP:0000089)2.25154555
53Supranuclear gaze palsy (HP:0000605)2.21846637
54Dysmetria (HP:0001310)2.20092376
55Alacrima (HP:0000522)2.18218771
56Sensory axonal neuropathy (HP:0003390)2.17824493
57Visual hallucinations (HP:0002367)2.17641982
58Truncal ataxia (HP:0002078)2.16670878
59Hemiparesis (HP:0001269)2.15076663
60Limb dystonia (HP:0002451)2.14496285
61Aplasia involving bones of the upper limbs (HP:0009823)2.14458800
62Aplasia of the phalanges of the hand (HP:0009802)2.14458800
63Aplasia involving bones of the extremities (HP:0009825)2.14458800
64Esotropia (HP:0000565)2.14343607
65Abnormality of the astrocytes (HP:0100707)2.13128155
66Astrocytoma (HP:0009592)2.13128155
67Abnormal hair whorl (HP:0010721)2.13072175
68Glioma (HP:0009733)2.11378963
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.10712334
70Cortical dysplasia (HP:0002539)2.10378347
71Epileptiform EEG discharges (HP:0011182)2.10155952
72Retinal dysplasia (HP:0007973)2.09763846
73Abnormality of the renal medulla (HP:0100957)2.06593516
74Vaginal atresia (HP:0000148)2.05322934
75Obstructive sleep apnea (HP:0002870)2.04973879
76Fair hair (HP:0002286)2.03523252
77Thyroid-stimulating hormone excess (HP:0002925)2.00282287
78Humeroradial synostosis (HP:0003041)1.98547308
79Synostosis involving the elbow (HP:0003938)1.98547308
80Amyotrophic lateral sclerosis (HP:0007354)1.98289908
81Poor eye contact (HP:0000817)1.97356097
82Congenital primary aphakia (HP:0007707)1.97282220
83Long clavicles (HP:0000890)1.97033118
84Abnormality of binocular vision (HP:0011514)1.96487659
85Diplopia (HP:0000651)1.96487659
86Scanning speech (HP:0002168)1.96010325
87Abnormality of the 4th metacarpal (HP:0010012)1.95925355
88Cutaneous syndactyly (HP:0012725)1.93232776
89Postaxial hand polydactyly (HP:0001162)1.92908264
90Gait imbalance (HP:0002141)1.92110937
91Type II lissencephaly (HP:0007260)1.91659401
92Fetal akinesia sequence (HP:0001989)1.91156076
93Medulloblastoma (HP:0002885)1.91009021
94EEG with generalized epileptiform discharges (HP:0011198)1.90099930
95Termporal pattern (HP:0011008)1.89699120
96Insidious onset (HP:0003587)1.89699120
97* Intellectual disability, severe (HP:0010864)1.89257194
98Nephrogenic diabetes insipidus (HP:0009806)1.88396538
99Dysdiadochokinesis (HP:0002075)1.87478467
100Decreased lacrimation (HP:0000633)1.87104474
101Akinesia (HP:0002304)1.86932047
102Chronic hepatic failure (HP:0100626)1.86516519
103Shawl scrotum (HP:0000049)1.86467147
104Mixed hearing impairment (HP:0000410)1.85391824
105Split foot (HP:0001839)1.84851042
106* Gastroesophageal reflux (HP:0002020)1.83729165
107Papillary thyroid carcinoma (HP:0002895)1.82849568
108Abnormality of the pubic bones (HP:0003172)1.82129916
109Genetic anticipation (HP:0003743)1.82041243
110* Widely spaced teeth (HP:0000687)1.81428557
111Abnormal social behavior (HP:0012433)1.81154409
112Impaired social interactions (HP:0000735)1.81154409
113Abnormality of the ischium (HP:0003174)1.80489123
114Action tremor (HP:0002345)1.80272306
115Hemiplegia (HP:0002301)1.79867920
116Hypsarrhythmia (HP:0002521)1.79334002
117Clumsiness (HP:0002312)1.79149888
118Dynein arm defect of respiratory motile cilia (HP:0012255)1.79054205
119Absent/shortened dynein arms (HP:0200106)1.79054205
120Sporadic (HP:0003745)1.78304680
121Esophageal atresia (HP:0002032)1.78303697
122Hyperthyroidism (HP:0000836)1.76887283
123Patellar aplasia (HP:0006443)1.76142458
124Autism (HP:0000717)1.75179319
125Neoplasm of the adrenal cortex (HP:0100641)1.75007862
126Stereotypic behavior (HP:0000733)1.74540365
127Urinary urgency (HP:0000012)1.73340450
128Short foot (HP:0001773)1.73213640
129Small hand (HP:0200055)1.73056043
130Spastic gait (HP:0002064)1.73012534
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.72978205
132Vitreoretinal degeneration (HP:0000655)1.72645982
133Anxiety (HP:0000739)1.72522059
134Facial hemangioma (HP:0000329)1.72371925
135Medial flaring of the eyebrow (HP:0010747)1.71461420
136Heterochromia iridis (HP:0001100)1.71409873
137Cutaneous finger syndactyly (HP:0010554)1.71019069
138* Cupped ear (HP:0000378)1.70797105
139Congenital malformation of the right heart (HP:0011723)1.70429750
140Double outlet right ventricle (HP:0001719)1.70429750
141Anteriorly placed anus (HP:0001545)1.69479921
142Polyphagia (HP:0002591)1.69345639
143* Narrow forehead (HP:0000341)1.69255767
144Intellectual disability, moderate (HP:0002342)1.69103973
145Preaxial foot polydactyly (HP:0001841)1.69053173
146Generalized myoclonic seizures (HP:0002123)1.69032918
147Overfolded helix (HP:0000396)1.68894086
148Sleep apnea (HP:0010535)1.68400309
149Anophthalmia (HP:0000528)1.67326373
150Abnormality of the antihelix (HP:0009738)1.67257844
151Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66642271
152Midline defect of the nose (HP:0004122)1.66209572
153Intestinal atresia (HP:0011100)1.66069075
154Labial hypoplasia (HP:0000066)1.66005378
155Abnormality of the parathyroid morphology (HP:0011766)1.65938158
156Genital tract atresia (HP:0001827)1.63544864
157Hydroureter (HP:0000072)1.63304011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.68417505
2EPHA44.30246450
3FRK3.69365330
4MARK13.29327602
5NTRK33.16236535
6WNK32.89246088
7MAP2K72.83566465
8MAP3K42.76911777
9PNCK2.66097681
10CCNB12.60193767
11TNIK2.52769600
12PRPF4B2.36354851
13MAP4K22.11477984
14PLK21.77969900
15NTRK21.76218022
16OXSR11.72739690
17STK391.70719849
18MAPK131.57010970
19PAK61.49907790
20BCR1.43430266
21RIPK41.41768127
22PKN11.41242694
23MINK11.36189745
24SIK21.33589186
25STK38L1.32481899
26FGR1.31454518
27SGK4941.31375863
28SGK2231.31375863
29FGFR21.28731438
30CDK51.28689012
31KSR11.23826829
32BMPR21.23385730
33MAP2K41.22299626
34CAMK1G1.18149297
35CAMK2B1.16509517
36SGK21.12803846
37CAMK2A1.10912093
38YES11.10645303
39UHMK11.07162826
40AKT31.05728686
41FES1.04816454
42NEK61.03478723
43PRKCE1.03057592
44MUSK1.02291637
45CDK191.02249212
46PINK11.01804779
47BMPR1B1.00754946
48MKNK21.00107948
49NTRK10.99505190
50PTK2B0.99002053
51ROCK20.98460342
52EPHB20.97122322
53PHKG10.96297275
54PHKG20.96297275
55CSNK1G20.96049894
56ACVR1B0.95903508
57DYRK20.95051905
58PRKCG0.94258677
59ERBB40.92655505
60CSNK1A1L0.90613707
61DYRK1A0.89966362
62LATS10.88423980
63DMPK0.87016050
64PLK40.85996962
65PAK30.84302661
66TRIM280.78299073
67TYRO30.78250199
68WNK10.76067128
69GRK50.75141384
70ADRBK20.74939117
71INSRR0.74502545
72BRD40.73894264
73SGK10.73834337
74CDK30.73566918
75GRK10.72586197
76CAMK2D0.72177251
77CSNK1G30.71596937
78MARK20.71121253
79PRKD30.68700987
80SGK30.68390299
81DAPK20.67603819
82TGFBR10.66645744
83CDK140.64155989
84MAP3K90.63398958
85STK110.62162193
86CDK180.60992386
87EPHA30.60516978
88CAMKK20.60086278
89CDK150.58863676
90PRKCQ0.58852373
91CSNK1D0.55802919
92GRK70.54869399
93CAMK10.54085149
94CSNK1G10.53759672
95FER0.52586866
96MAP3K120.52354538
97PIK3CA0.51686863
98PRKCH0.51393736
99MAP3K60.51384154
100MKNK10.51265036
101CAMK40.50847430
102PRKG10.50016016
103CDK11A0.48261450
104MAPKAPK50.48208819
105MAPK70.46326824
106ERBB30.46240758
107ERBB20.46233363
108FYN0.45988909
109DDR20.45676730
110ICK0.45123451
111MAPK40.44371535
112ROCK10.44117396
113PRKCZ0.43415672
114NME10.43395039
115IRAK10.42626630
116CAMK2G0.42258707
117MAPK100.42197960
118ZAK0.41376580
119NUAK10.39632010
120SIK30.39025835
121VRK10.38926094
122PRKACA0.38640700
123WEE10.38011330
124TIE10.37864004
125DAPK10.37090030
126MAPK120.36093505
127RPS6KA30.35103642
128RPS6KA40.34599203
129PRKDC0.33809140
130PRKACB0.33379273
131SRPK10.33336777
132CSNK1A10.33281797
133ADRBK10.31949034
134GSK3B0.31374485
135OBSCN0.29718404
136MAPK80.29695747

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.78285207
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.79969583
3Glutamatergic synapse_Homo sapiens_hsa047242.63597923
4GABAergic synapse_Homo sapiens_hsa047272.57548874
5Morphine addiction_Homo sapiens_hsa050322.43963568
6Circadian entrainment_Homo sapiens_hsa047132.43510466
7Long-term potentiation_Homo sapiens_hsa047202.27353926
8Axon guidance_Homo sapiens_hsa043602.21410361
9Taste transduction_Homo sapiens_hsa047422.10576935
10Serotonergic synapse_Homo sapiens_hsa047262.07660838
11Amphetamine addiction_Homo sapiens_hsa050312.01168433
12Long-term depression_Homo sapiens_hsa047301.96713357
13Dopaminergic synapse_Homo sapiens_hsa047281.94076796
14Synaptic vesicle cycle_Homo sapiens_hsa047211.91421533
15Salivary secretion_Homo sapiens_hsa049701.88089320
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87484266
17Olfactory transduction_Homo sapiens_hsa047401.73211285
18Renin secretion_Homo sapiens_hsa049241.63615185
19Cholinergic synapse_Homo sapiens_hsa047251.61731789
20Calcium signaling pathway_Homo sapiens_hsa040201.55702597
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52651714
22Gastric acid secretion_Homo sapiens_hsa049711.45052589
23Butanoate metabolism_Homo sapiens_hsa006501.44668325
24Oxytocin signaling pathway_Homo sapiens_hsa049211.42797415
25Insulin secretion_Homo sapiens_hsa049111.37864724
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33310164
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28204590
28Collecting duct acid secretion_Homo sapiens_hsa049661.27798455
29Cocaine addiction_Homo sapiens_hsa050301.26978748
30cAMP signaling pathway_Homo sapiens_hsa040241.26791918
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26301897
32Non-homologous end-joining_Homo sapiens_hsa034501.26164671
33ErbB signaling pathway_Homo sapiens_hsa040121.25332694
34Gap junction_Homo sapiens_hsa045401.24140600
35Phototransduction_Homo sapiens_hsa047441.20864197
36GnRH signaling pathway_Homo sapiens_hsa049121.20342522
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17734667
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16357878
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16056801
40Melanogenesis_Homo sapiens_hsa049161.13358676
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03291714
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03262140
43Glioma_Homo sapiens_hsa052141.00493293
44Nitrogen metabolism_Homo sapiens_hsa009101.00412286
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.99611286
46Wnt signaling pathway_Homo sapiens_hsa043100.99340448
47Choline metabolism in cancer_Homo sapiens_hsa052310.99250981
48Fanconi anemia pathway_Homo sapiens_hsa034600.97201664
49Ras signaling pathway_Homo sapiens_hsa040140.96711450
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95259149
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94112974
52Estrogen signaling pathway_Homo sapiens_hsa049150.93401783
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93317165
54Circadian rhythm_Homo sapiens_hsa047100.92645237
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91118131
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.89414756
57Dilated cardiomyopathy_Homo sapiens_hsa054140.88766462
58Dorso-ventral axis formation_Homo sapiens_hsa043200.88698154
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87848198
60MAPK signaling pathway_Homo sapiens_hsa040100.86485844
61Vibrio cholerae infection_Homo sapiens_hsa051100.83687668
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82933370
63Basal transcription factors_Homo sapiens_hsa030220.82126120
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81442708
65Rap1 signaling pathway_Homo sapiens_hsa040150.80741607
66Renal cell carcinoma_Homo sapiens_hsa052110.80485248
67Cardiac muscle contraction_Homo sapiens_hsa042600.78145327
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74560963
69Pancreatic secretion_Homo sapiens_hsa049720.74176440
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74004371
71Linoleic acid metabolism_Homo sapiens_hsa005910.73449626
72Type II diabetes mellitus_Homo sapiens_hsa049300.73302105
73TGF-beta signaling pathway_Homo sapiens_hsa043500.71794257
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70849417
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70848660
76MicroRNAs in cancer_Homo sapiens_hsa052060.70245834
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70241976
78African trypanosomiasis_Homo sapiens_hsa051430.69824042
79Propanoate metabolism_Homo sapiens_hsa006400.69547519
80Hedgehog signaling pathway_Homo sapiens_hsa043400.69452716
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.68425273
82Ovarian steroidogenesis_Homo sapiens_hsa049130.66982793
83Ether lipid metabolism_Homo sapiens_hsa005650.66827739
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66138175
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63442106
86Regulation of autophagy_Homo sapiens_hsa041400.63266335
87Alcoholism_Homo sapiens_hsa050340.62995666
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61733818
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60821059
90ABC transporters_Homo sapiens_hsa020100.60787944
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60674273
92Alzheimers disease_Homo sapiens_hsa050100.59611826
93Melanoma_Homo sapiens_hsa052180.59312598
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57953426
95Lysine degradation_Homo sapiens_hsa003100.55757468
96Rheumatoid arthritis_Homo sapiens_hsa053230.54369782
97Colorectal cancer_Homo sapiens_hsa052100.54135844
98beta-Alanine metabolism_Homo sapiens_hsa004100.53682232
99Basal cell carcinoma_Homo sapiens_hsa052170.53658100
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53596261
101Tight junction_Homo sapiens_hsa045300.52492944
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50388775
103RNA degradation_Homo sapiens_hsa030180.49579542
104FoxO signaling pathway_Homo sapiens_hsa040680.49523254
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49428646
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46984485
107VEGF signaling pathway_Homo sapiens_hsa043700.46452507
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45749954
109Thyroid hormone synthesis_Homo sapiens_hsa049180.44258817
110Selenocompound metabolism_Homo sapiens_hsa004500.43559930
111Glycerolipid metabolism_Homo sapiens_hsa005610.43155112
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42941903
113Type I diabetes mellitus_Homo sapiens_hsa049400.42873844
114Oocyte meiosis_Homo sapiens_hsa041140.42859331
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42558234
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41529398
117Endometrial cancer_Homo sapiens_hsa052130.41121269
118Tryptophan metabolism_Homo sapiens_hsa003800.40959834
119Hippo signaling pathway_Homo sapiens_hsa043900.40364783
120Focal adhesion_Homo sapiens_hsa045100.39864506
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39713236
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39094389
123Endocytosis_Homo sapiens_hsa041440.38633515
124Chemokine signaling pathway_Homo sapiens_hsa040620.36829760
125Sphingolipid metabolism_Homo sapiens_hsa006000.36771748
126Oxidative phosphorylation_Homo sapiens_hsa001900.36455498
127Inositol phosphate metabolism_Homo sapiens_hsa005620.35047312
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34987892
129Prostate cancer_Homo sapiens_hsa052150.33533845

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