TCF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive T cell selection (GO:0043368)8.72761914
2regulation of gamma-delta T cell differentiation (GO:0045586)8.70677451
3negative T cell selection (GO:0043383)8.63059013
4positive regulation of gamma-delta T cell activation (GO:0046645)8.36888676
5regulation of gamma-delta T cell activation (GO:0046643)7.79944600
6T cell selection (GO:0045058)7.57954079
7negative regulation of thymocyte apoptotic process (GO:0070244)7.48819153
8* V(D)J recombination (GO:0033151)7.35397478
9activated T cell proliferation (GO:0050798)7.20589739
10positive regulation of interleukin-2 biosynthetic process (GO:0045086)7.05965357
11negative thymic T cell selection (GO:0045060)6.76345184
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.72993557
13positive thymic T cell selection (GO:0045059)6.51418248
14T cell receptor signaling pathway (GO:0050852)6.29538724
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.16749585
16negative regulation of cell killing (GO:0031342)6.16749585
17interferon-gamma production (GO:0032609)6.11686760
18thymic T cell selection (GO:0045061)6.09687959
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.90850588
20T cell costimulation (GO:0031295)5.11044833
21positive regulation of interleukin-2 production (GO:0032743)5.01361960
22lymphocyte costimulation (GO:0031294)5.01249009
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.00215250
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.00215250
25antigen receptor-mediated signaling pathway (GO:0050851)4.91234095
26response to interleukin-15 (GO:0070672)4.89206805
27regulation of thymocyte apoptotic process (GO:0070243)4.88440516
28regulation of interleukin-2 biosynthetic process (GO:0045076)4.87762943
29* T cell differentiation (GO:0030217)4.68649294
30regulation of T cell tolerance induction (GO:0002664)4.60753625
31mucosal-associated lymphoid tissue development (GO:0048537)4.45541338
32Peyers patch development (GO:0048541)4.45541338
33regulation of T cell receptor signaling pathway (GO:0050856)4.41109816
34* alpha-beta T cell differentiation (GO:0046632)4.26203815
35negative regulation of lymphocyte mediated immunity (GO:0002707)4.25310827
36regulation of isotype switching to IgG isotypes (GO:0048302)4.21014027
37* alpha-beta T cell activation (GO:0046631)4.15392466
38cellular response to interleukin-15 (GO:0071350)4.15088908
39negative regulation of T cell apoptotic process (GO:0070233)4.13050849
40antigen processing and presentation of endogenous antigen (GO:0019883)4.09839246
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.00925643
42mast cell activation (GO:0045576)3.90687090
43modulation by virus of host process (GO:0019054)3.87722605
44regulation of regulatory T cell differentiation (GO:0045589)3.87347448
45regulation of defense response to virus by virus (GO:0050690)3.86578867
46T cell homeostasis (GO:0043029)3.83339193
47regulation of granulocyte differentiation (GO:0030852)3.83173845
48positive regulation of calcium-mediated signaling (GO:0050850)3.82169163
49positive regulation of tolerance induction (GO:0002645)3.79083322
50regulation of interleukin-2 production (GO:0032663)3.76777784
51* somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.73687815
52* somatic cell DNA recombination (GO:0016444)3.73687815
53T cell differentiation in thymus (GO:0033077)3.73191265
54leukocyte aggregation (GO:0070486)3.72753628
55B cell receptor signaling pathway (GO:0050853)3.70370149
56positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.68500375
57negative regulation of leukocyte mediated immunity (GO:0002704)3.65344773
58* T cell activation (GO:0042110)3.62862470
59mast cell activation involved in immune response (GO:0002279)3.56378159
60mast cell degranulation (GO:0043303)3.56378159
61negative regulation of erythrocyte differentiation (GO:0045647)3.54572259
62T cell migration (GO:0072678)3.51764592
63positive regulation of T cell differentiation in thymus (GO:0033089)3.48924290
64response to muramyl dipeptide (GO:0032495)3.47250342
65modulation by symbiont of host cellular process (GO:0044068)3.46093683
66* somatic diversification of immune receptors (GO:0002200)3.40791218
67CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.39332191
68regulation of T cell mediated cytotoxicity (GO:0001914)3.37898212
69immune response-activating cell surface receptor signaling pathway (GO:0002429)3.33288759
70regulation of alpha-beta T cell proliferation (GO:0046640)3.28740469
71regulation of alpha-beta T cell activation (GO:0046634)3.27475986
72detection of bacterium (GO:0016045)3.26421003
73positive regulation of granulocyte differentiation (GO:0030854)3.26075490
74regulation of tolerance induction (GO:0002643)3.21735684
75positive regulation by symbiont of host defense response (GO:0052509)3.21208702
76modulation by symbiont of host defense response (GO:0052031)3.21208702
77modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.21208702
78modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.21208702
79positive regulation by organism of defense response of other organism involved in symbiotic interact3.21208702
80modulation by symbiont of host immune response (GO:0052553)3.21208702
81lymphocyte homeostasis (GO:0002260)3.21142974
82positive regulation of B cell differentiation (GO:0045579)3.18816812
83negative regulation of T cell receptor signaling pathway (GO:0050860)3.17549246
84lymph node development (GO:0048535)3.16539249
85positive regulation of alpha-beta T cell activation (GO:0046635)3.15838803
86detection of other organism (GO:0098543)3.15703019
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15418564
88positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14976107
89negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.14961101
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.14600553
91T cell proliferation (GO:0042098)3.13238052
92histone H3-K36 demethylation (GO:0070544)3.12364757
93positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11461128
94antigen processing and presentation via MHC class Ib (GO:0002475)3.11438061
95regulation of natural killer cell mediated immunity (GO:0002715)3.09524645
96regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.09524645
97regulation of leukocyte mediated cytotoxicity (GO:0001910)3.08531805
98natural killer cell differentiation (GO:0001779)3.07703734
99positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.07507904
100positive regulation of natural killer cell mediated immunity (GO:0002717)3.07507904
101CD4-positive, alpha-beta T cell activation (GO:0035710)3.06373653
102negative regulation of lymphocyte apoptotic process (GO:0070229)3.05794866
103* lymphocyte differentiation (GO:0030098)3.05567157
104regulation of interleukin-4 production (GO:0032673)3.03381785
105positive regulation of T cell activation (GO:0050870)3.01891014
106negative regulation of glycoprotein biosynthetic process (GO:0010561)3.01519628
107tolerance induction (GO:0002507)3.01041933
108cellular extravasation (GO:0045123)3.00949908
109regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.00185686
110cellular hyperosmotic response (GO:0071474)2.99841939
111positive regulation of alpha-beta T cell differentiation (GO:0046638)2.99247404
112regulation of response to interferon-gamma (GO:0060330)2.98033821
113CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.97643985
114T-helper cell differentiation (GO:0042093)2.97643985
115regulation of B cell receptor signaling pathway (GO:0050855)2.97107941
116positive regulation of histone deacetylation (GO:0031065)2.97056329
117regulation of T cell differentiation (GO:0045580)2.94748265
118regulation of interleukin-12 biosynthetic process (GO:0045075)2.94257152
119regulation of alpha-beta T cell differentiation (GO:0046637)2.94181652
120positive regulation of isotype switching (GO:0045830)2.92205832
121positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.90804302
122positive regulation of T cell differentiation (GO:0045582)2.89855264
123negative regulation of innate immune response (GO:0045824)2.88294089
124negative regulation of phagocytosis (GO:0050765)2.87206818
125regulation of cell killing (GO:0031341)2.86760462
126T cell lineage commitment (GO:0002360)2.84969150
127histone monoubiquitination (GO:0010390)2.81838131
128regulation of T cell activation (GO:0050863)2.78926316
129negative regulation of T cell mediated immunity (GO:0002710)2.77433042
130regulation of T cell apoptotic process (GO:0070232)2.75934851
131regulation of B cell differentiation (GO:0045577)2.74874003
132negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.74711821
133T cell differentiation involved in immune response (GO:0002292)2.74121169
134alpha-beta T cell differentiation involved in immune response (GO:0002293)2.74121169
135alpha-beta T cell activation involved in immune response (GO:0002287)2.74121169
136signal complex assembly (GO:0007172)2.71495350
137DNA unwinding involved in DNA replication (GO:0006268)2.70530112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.19889912
2E2F7_22180533_ChIP-Seq_HELA_Human6.59838215
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.47279993
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.66340846
5MYC_22102868_ChIP-Seq_BL_Human4.53887544
6* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.51079442
7* RUNX_20019798_ChIP-Seq_JUKART_Human3.33434311
8MYB_26560356_Chip-Seq_TH2_Human3.29554440
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.07399640
10* UTX_26944678_Chip-Seq_JUKART_Human2.93819959
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.92944668
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.89685239
13MAF_26560356_Chip-Seq_TH1_Human2.82810119
14VDR_21846776_ChIP-Seq_THP-1_Human2.62007649
15MYB_26560356_Chip-Seq_TH1_Human2.56227053
16* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.48126064
17* TCF7_22412390_ChIP-Seq_EML_Mouse2.45552709
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33983844
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31846399
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20963885
21KDM2B_26808549_Chip-Seq_DND41_Human2.19758302
22* GATA3_27048872_Chip-Seq_THYMUS_Human2.16119634
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.11639443
24IRF8_22096565_ChIP-ChIP_GC-B_Human2.09590006
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07378268
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.04788602
27CIITA_25753668_ChIP-Seq_RAJI_Human1.99990165
28SCL_19346495_ChIP-Seq_HPC-7_Human1.98275302
29MAF_26560356_Chip-Seq_TH2_Human1.94072759
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85252435
31* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77495480
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.76124986
33VDR_24763502_ChIP-Seq_THP-1_Human1.75013847
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71979906
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71719881
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70495498
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53798357
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51768699
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51273344
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42866504
41RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42239195
42KDM2B_26808549_Chip-Seq_JURKAT_Human1.40847414
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39398905
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.37884793
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37407763
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34809908
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34271359
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33985115
49SPI1_23547873_ChIP-Seq_NB4_Human1.33140830
50* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32958922
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31003998
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30711944
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.29165344
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26587418
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22943710
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21505095
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20551753
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14951071
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.14853910
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14666422
61SPI1_23127762_ChIP-Seq_K562_Human1.14221254
62VDR_24787735_ChIP-Seq_THP-1_Human1.13474993
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.12373533
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11220820
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10645049
66FOXP3_21729870_ChIP-Seq_TREG_Human1.10360129
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08432265
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.08234031
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07236185
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05927170
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05777458
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05455781
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04826199
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03662039
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03484313
76VDR_23849224_ChIP-Seq_CD4+_Human1.03165014
77NCOR1_26117541_ChIP-Seq_K562_Human1.01751483
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99891536
79KDM5A_27292631_Chip-Seq_BREAST_Human0.99647962
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98894803
81IRF8_27001747_Chip-Seq_BMDM_Mouse0.98677064
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98496646
83E2F1_21310950_ChIP-Seq_MCF-7_Human0.97797368
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96006294
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95549048
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94831935
87GATA1_19941826_ChIP-Seq_K562_Human0.93401716
88GATA3_26560356_Chip-Seq_TH2_Human0.93236066
89XRN2_22483619_ChIP-Seq_HELA_Human0.92561456
90TP63_19390658_ChIP-ChIP_HaCaT_Human0.91565063
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90247310
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88337898
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87737026
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86957729
95PU_27001747_Chip-Seq_BMDM_Mouse0.86956146
96BCL6_27268052_Chip-Seq_Bcells_Human0.86057740
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85011440
98PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84988988
99BCOR_27268052_Chip-Seq_Bcells_Human0.84824568
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82915746
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82117625
102* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80599730
103FOXO3_23340844_ChIP-Seq_DLD1_Human0.80203338
104ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80054989
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.79859035
106GATA3_26560356_Chip-Seq_TH1_Human0.79849198
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79706869
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79508233
109RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79380734
110ELK1_19687146_ChIP-ChIP_HELA_Human0.78417832
111ELF1_20517297_ChIP-Seq_JURKAT_Human0.77810707
112IRF8_21731497_ChIP-ChIP_J774_Mouse0.77781163
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77679249
114CTCF_27219007_Chip-Seq_ERYTHROID_Human0.77274367
115CTCF_21964334_ChIP-Seq_BJAB-B_Human0.76735920
116MYC_18555785_ChIP-Seq_MESCs_Mouse0.74806835
117* LXR_22292898_ChIP-Seq_THP-1_Human0.74575252
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74418537
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73068222
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.72031739
121CHD1_26751641_Chip-Seq_LNCaP_Human0.71362694
122RUNX1_27514584_Chip-Seq_MCF-7_Human0.70340465
123* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.69514136
124RACK7_27058665_Chip-Seq_MCF-7_Human0.69462028
125SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.69041093
126PU.1_20513432_ChIP-Seq_Bcells_Mouse0.68705216
127KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.68551487
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.68204362
129FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67881344
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.66688663
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.65333794
132CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65239276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.34521983
2MP0002166_altered_tumor_susceptibility3.97259005
3MP0005671_abnormal_response_to3.78064884
4* MP0000703_abnormal_thymus_morphology3.75224124
5MP0000685_abnormal_immune_system3.41909344
6MP0002006_tumorigenesis3.15778138
7* MP0002398_abnormal_bone_marrow2.80787235
8MP0002132_abnormal_respiratory_system2.76380333
9MP0004947_skin_inflammation2.70416020
10MP0009333_abnormal_splenocyte_physiolog2.66344085
11MP0001800_abnormal_humoral_immune2.45963278
12* MP0002722_abnormal_immune_system2.44314588
13MP0010155_abnormal_intestine_physiology2.42123725
14MP0009278_abnormal_bone_marrow2.40248954
15* MP0000716_abnormal_immune_system2.28912098
16MP0002420_abnormal_adaptive_immunity2.28691195
17MP0005409_darkened_coat_color2.26984805
18MP0001835_abnormal_antigen_presentation2.24629236
19MP0001819_abnormal_immune_cell2.24584833
20MP0010094_abnormal_chromosome_stability2.24459195
21MP0005387_immune_system_phenotype2.23983624
22MP0001790_abnormal_immune_system2.23983624
23MP0002405_respiratory_system_inflammati2.23768795
24MP0000689_abnormal_spleen_morphology2.20293388
25MP0001849_ear_inflammation2.15313484
26MP0002723_abnormal_immune_serum2.14931476
27MP0005000_abnormal_immune_tolerance2.13193392
28MP0004808_abnormal_hematopoietic_stem2.11605192
29MP0009785_altered_susceptibility_to1.98726441
30MP0003300_gastrointestinal_ulcer1.98628097
31MP0002396_abnormal_hematopoietic_system1.95850783
32MP0002933_joint_inflammation1.93627179
33MP0006082_CNS_inflammation1.87202092
34* MP0002429_abnormal_blood_cell1.85409820
35MP0002452_abnormal_antigen_presenting1.82706142
36MP0005397_hematopoietic_system_phenotyp1.73059250
37MP0001545_abnormal_hematopoietic_system1.73059250
38MP0010352_gastrointestinal_tract_polyps1.63027839
39MP0005025_abnormal_response_to1.59530258
40MP0003866_abnormal_defecation1.58269616
41MP0001533_abnormal_skeleton_physiology1.55341695
42MP0001873_stomach_inflammation1.54750625
43MP0005174_abnormal_tail_pigmentation1.45514834
44MP0004381_abnormal_hair_follicle1.45069617
45MP0008057_abnormal_DNA_replication1.35245186
46MP0005076_abnormal_cell_differentiation1.33141405
47MP0001845_abnormal_inflammatory_respons1.32996283
48MP0003077_abnormal_cell_cycle1.29071337
49MP0002095_abnormal_skin_pigmentation1.27978617
50MP0003436_decreased_susceptibility_to1.25425919
51MP0008961_abnormal_basal_metabolism1.25325877
52MP0000490_abnormal_crypts_of1.24146584
53MP0003724_increased_susceptibility_to1.23732866
54MP0000015_abnormal_ear_pigmentation1.21267915
55MP0002019_abnormal_tumor_incidence1.21215458
56MP0003693_abnormal_embryo_hatching1.19731130
57MP0000858_altered_metastatic_potential1.16966814
58MP0005464_abnormal_platelet_physiology1.15112195
59MP0002148_abnormal_hypersensitivity_rea1.13675476
60MP0004957_abnormal_blastocyst_morpholog1.12569145
61MP0002009_preneoplasia1.05047060
62MP0001853_heart_inflammation1.04918220
63MP0001243_abnormal_dermal_layer1.04220925
64MP0003111_abnormal_nucleus_morphology1.02700999
65MP0003045_fibrosis1.02591213
66MP0004510_myositis1.01869221
67MP0002138_abnormal_hepatobiliary_system1.01785617
68MP0002419_abnormal_innate_immunity1.01762404
69MP0005310_abnormal_salivary_gland1.01025739
70MP0008007_abnormal_cellular_replicative0.97368067
71MP0003828_pulmonary_edema0.96824443
72MP0003303_peritoneal_inflammation0.94419196
73MP0003172_abnormal_lysosome_physiology0.91226121
74MP0000350_abnormal_cell_proliferation0.89898004
75MP0005451_abnormal_body_composition0.87846678
76MP0001348_abnormal_lacrimal_gland0.87109328
77MP0001986_abnormal_taste_sensitivity0.83732351
78MP0002277_abnormal_respiratory_mucosa0.82197714
79MP0005075_abnormal_melanosome_morpholog0.82138427
80MP0000465_gastrointestinal_hemorrhage0.80456331
81MP0008260_abnormal_autophagy0.79138280
82MP0001730_embryonic_growth_arrest0.78153654
83MP0001663_abnormal_digestive_system0.77767239
84MP0002998_abnormal_bone_remodeling0.76623659
85MP0008770_decreased_survivor_rate0.75050972
86MP0002075_abnormal_coat/hair_pigmentati0.74759101
87MP0003191_abnormal_cellular_cholesterol0.73885212
88MP0008877_abnormal_DNA_methylation0.73767026
89MP0000383_abnormal_hair_follicle0.73730622
90MP0001879_abnormal_lymphatic_vessel0.72139770
91MP0001851_eye_inflammation0.71962062
92MP0003448_altered_tumor_morphology0.70850819
93MP0009764_decreased_sensitivity_to0.70298904
94MP0005023_abnormal_wound_healing0.68841945
95MP0002163_abnormal_gland_morphology0.67472659
96MP0004185_abnormal_adipocyte_glucose0.67187447
97MP0008058_abnormal_DNA_repair0.65967628
98MP0000477_abnormal_intestine_morphology0.65771780
99MP0009115_abnormal_fat_cell0.65533283
100MP0009763_increased_sensitivity_to0.64438003
101MP0001191_abnormal_skin_condition0.64373198
102MP0004883_abnormal_blood_vessel0.63748215
103MP0003959_abnormal_lean_body0.62211082
104MP0000609_abnormal_liver_physiology0.62020498
105MP0002086_abnormal_extraembryonic_tissu0.61912068
106MP0002928_abnormal_bile_duct0.60639830
107MP0004130_abnormal_muscle_cell0.58605832
108MP0000313_abnormal_cell_death0.58394412
109MP0003787_abnormal_imprinting0.57894164
110MP0002088_abnormal_embryonic_growth/wei0.56557724
111MP0002970_abnormal_white_adipose0.56021844
112MP0000367_abnormal_coat/_hair0.55901727
113MP0003984_embryonic_growth_retardation0.54716618
114MP0001216_abnormal_epidermal_layer0.54189632
115MP0009765_abnormal_xenobiotic_induced0.53679785
116MP0008469_abnormal_protein_level0.51608633
117MP0010307_abnormal_tumor_latency0.51460772
118MP0004197_abnormal_fetal_growth/weight/0.51046219
119MP0002080_prenatal_lethality0.50685036
120MP0002693_abnormal_pancreas_physiology0.50422706
121MP0003183_abnormal_peptide_metabolism0.49511164
122MP0000249_abnormal_blood_vessel0.47025931
123MP0005390_skeleton_phenotype0.46779865
124MP0003795_abnormal_bone_structure0.44027833
125MP0001919_abnormal_reproductive_system0.43782915
126MP0003252_abnormal_bile_duct0.41642136
127MP0003646_muscle_fatigue0.39954470
128MP0002083_premature_death0.37705360
129MP0003279_aneurysm0.36957593
130MP0008569_lethality_at_weaning0.36484345
131MP0005381_digestive/alimentary_phenotyp0.35975748

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)8.66091685
2Abnormality of B cell number (HP:0010975)8.66091685
3Severe combined immunodeficiency (HP:0004430)8.59302765
4Combined immunodeficiency (HP:0005387)7.77155811
5Panhypogammaglobulinemia (HP:0003139)7.68909548
6Hypoplasia of the thymus (HP:0000778)7.67083414
7Thyroiditis (HP:0100646)7.44131998
8Eosinophilia (HP:0001880)6.96000867
9Recurrent viral infections (HP:0004429)6.22199554
10Abnormality of T cells (HP:0002843)5.82342078
11Granulocytopenia (HP:0001913)5.75606677
12Abnormality of eosinophils (HP:0001879)5.64709226
13Hypoproteinemia (HP:0003075)4.85994165
14Recurrent fungal infections (HP:0002841)4.72310754
15IgG deficiency (HP:0004315)4.66207420
16Leukocytosis (HP:0001974)4.23955176
17Abnormality of the fingertips (HP:0001211)3.93320040
18Recurrent bacterial skin infections (HP:0005406)3.82208695
19Recurrent abscess formation (HP:0002722)3.80472107
20Retrobulbar optic neuritis (HP:0100654)3.76357568
21Optic neuritis (HP:0100653)3.76357568
22Orchitis (HP:0100796)3.67347253
23Mediastinal lymphadenopathy (HP:0100721)3.37651986
24Vasculitis (HP:0002633)3.32132506
25Elevated erythrocyte sedimentation rate (HP:0003565)3.29148073
26Erythroderma (HP:0001019)3.22047464
27Papilledema (HP:0001085)3.14901358
28Abnormality of macrophages (HP:0004311)3.13893548
29Aplasia/Hypoplasia of the thymus (HP:0010515)2.97821303
30Obstructive lung disease (HP:0006536)2.92280969
31Chronic obstructive pulmonary disease (HP:0006510)2.92280969
32Recurrent skin infections (HP:0001581)2.91917771
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.82803238
34Stomatitis (HP:0010280)2.82780645
35Pustule (HP:0200039)2.80473519
36Pulmonary infiltrates (HP:0002113)2.74954336
37Colitis (HP:0002583)2.71805714
38Keratoconjunctivitis sicca (HP:0001097)2.68480431
39Basal cell carcinoma (HP:0002671)2.65123458
40Agammaglobulinemia (HP:0004432)2.61252159
41Chest pain (HP:0100749)2.57244420
42Nasal polyposis (HP:0100582)2.56522296
43Keratoconjunctivitis (HP:0001096)2.55906605
44Lymphoma (HP:0002665)2.55234341
45Chronic otitis media (HP:0000389)2.51865192
46Recurrent gram-negative bacterial infections (HP:0005420)2.51506673
47Recurrent bronchitis (HP:0002837)2.51029856
48Autoimmune thrombocytopenia (HP:0001973)2.50137653
49Abnormality of the thymus (HP:0000777)2.49109973
50Slow saccadic eye movements (HP:0000514)2.46298194
51Recurrent cutaneous fungal infections (HP:0011370)2.46076508
52Chronic mucocutaneous candidiasis (HP:0002728)2.46076508
53Gastrointestinal stroma tumor (HP:0100723)2.42187676
54Meningitis (HP:0001287)2.41123530
55IgM deficiency (HP:0002850)2.39863396
56Hypochromic microcytic anemia (HP:0004840)2.34725096
57Cellular immunodeficiency (HP:0005374)2.33807614
58Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.31219052
59Autoimmune hemolytic anemia (HP:0001890)2.30833856
60Pulmonary embolism (HP:0002204)2.30788119
61Bicuspid aortic valve (HP:0001647)2.28671590
62Cellulitis (HP:0100658)2.26938530
63Abnormality of the columella (HP:0009929)2.23982804
64Joint swelling (HP:0001386)2.18826061
65Volvulus (HP:0002580)2.17860288
66Stomach cancer (HP:0012126)2.17658399
67Gingivitis (HP:0000230)2.17623388
68Microcytic anemia (HP:0001935)2.16959552
69Papilloma (HP:0012740)2.16945070
70Verrucae (HP:0200043)2.16945070
71Abnormality of the nasal mucosa (HP:0000433)2.08973869
72Anorexia (HP:0002039)2.07217557
73Urticaria (HP:0001025)2.06736201
74Lymphopenia (HP:0001888)2.05088034
75Increased IgM level (HP:0003496)2.03671600
76Abnormality of cells of the lymphoid lineage (HP:0012140)2.03167225
77Spontaneous hematomas (HP:0007420)2.01147598
78T lymphocytopenia (HP:0005403)10.8269726
79Abnormality of T cell number (HP:0011839)10.2630650
80Acute hepatic failure (HP:0006554)1.93454994
81Arterial thrombosis (HP:0004420)1.92919695
82Hematochezia (HP:0002573)1.91020581
83Viral hepatitis (HP:0006562)1.90542172
84Abnormality of T cell physiology (HP:0011840)1.89953042
85Deep philtrum (HP:0002002)1.87314019
86Recurrent sinusitis (HP:0011108)1.86300347
87Abnormality of the pleura (HP:0002103)1.83572724
88Gangrene (HP:0100758)1.82241617
89Teleangiectasia of the skin (HP:0100585)1.82064529
90Chronic diarrhea (HP:0002028)1.81780399
91Subacute progressive viral hepatitis (HP:0006572)1.78211218
92Osteomyelitis (HP:0002754)1.77440807
93Broad face (HP:0000283)1.76281144
94Gingival bleeding (HP:0000225)1.75296754
95Myositis (HP:0100614)1.73054373
96Hyperacusis (HP:0010780)1.71033558
97Increased IgE level (HP:0003212)1.67604924
98Encephalitis (HP:0002383)1.66355507
99Broad palm (HP:0001169)1.65636238
100Sparse lateral eyebrow (HP:0005338)1.65040645
101Abnormal platelet volume (HP:0011876)1.61926472
102Bronchiectasis (HP:0002110)1.58958821
103Eczematoid dermatitis (HP:0000976)1.58634450
104Cutis marmorata (HP:0000965)1.56214213
105Sepsis (HP:0100806)1.55134497
106Gastrointestinal inflammation (HP:0004386)1.53729018
107Acute lymphatic leukemia (HP:0006721)1.51328607
108Inflammation of the large intestine (HP:0002037)1.47023601
109Prominent nose (HP:0000448)1.46691962
110Dislocated radial head (HP:0003083)1.45810573
111Long eyelashes (HP:0000527)1.45766778
112Heterotopia (HP:0002282)1.44373284
113Increased nuchal translucency (HP:0010880)1.43566220
114Trigonocephaly (HP:0000243)1.42710341
115Abnormality of oral frenula (HP:0000190)1.41373193
116Recurrent otitis media (HP:0000403)1.40493354
117Proximal placement of thumb (HP:0009623)1.40434910
118Increased density of long bones (HP:0006392)1.39825242
119Hypergammaglobulinemia (HP:0010702)1.37521920
120Persistence of primary teeth (HP:0006335)1.37463571
121Prolonged bleeding time (HP:0003010)1.36085250
122Bronchitis (HP:0012387)1.36056758
123Abnormality of the radial head (HP:0003995)1.34585655
124Ureteral stenosis (HP:0000071)1.34490303
125Poikiloderma (HP:0001029)1.31010227
126Hemoptysis (HP:0002105)1.29728056
127Abnormal foot bone ossification (HP:0010675)1.29518443
128Gastrointestinal infarctions (HP:0005244)1.28468838
129Deviation of the thumb (HP:0009603)1.27821715
130Hepatitis (HP:0012115)1.27750955
131Depressed nasal tip (HP:0000437)1.26860464
132Increased mean platelet volume (HP:0011877)1.26857880
133Aortic aneurysm (HP:0004942)1.26524080
134Seborrheic dermatitis (HP:0001051)1.26184846
135Mitral regurgitation (HP:0001653)1.26139237
136IgA deficiency (HP:0002720)1.25333068
137Amaurosis fugax (HP:0100576)1.25207843
138Macroorchidism (HP:0000053)1.25007110
139Acute myeloid leukemia (HP:0004808)1.23596614
140Hypochromic anemia (HP:0001931)1.22549275
141Ureteral obstruction (HP:0006000)1.20594357
142Skin tags (HP:0010609)1.19381131
143Epistaxis (HP:0000421)1.19272348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.89334033
2MAP4K15.05145797
3PRPF4B3.21015175
4ITK3.12157206
5ZAP703.08673154
6GRK62.92803492
7STK102.68999735
8EEF2K2.52435366
9RIPK42.52136351
10CDK122.44673626
11MAP3K102.43866784
12FGFR42.40967952
13NLK2.30724163
14TAOK32.28077675
15PKN22.18982888
16JAK32.13396691
17MST42.01987592
18TYK21.96203039
19FGFR31.91256292
20PDGFRB1.79287611
21LCK1.72114985
22CSK1.67588736
23SYK1.67566630
24IRAK41.61534619
25MAP3K71.54222677
26CAMKK11.51427117
27YES11.47164708
28HCK1.45801703
29BLK1.43909269
30MAPK71.42603904
31IKBKE1.39744778
32SMG11.29740163
33FGFR21.29551584
34CDC71.27955660
35PRKCH1.25941834
36PRKCQ1.25575763
37TYRO31.22352083
38LRRK21.21029591
39MAP2K31.17165891
40TRIB31.16919661
41BRD41.15476493
42ERN11.13023581
43MAP2K21.12606716
44BTK1.11634146
45TEC1.09765409
46SIK21.09610410
47RPS6KB21.03421287
48CLK11.03322920
49JAK11.03322182
50PTK60.98379283
51SIK10.95471904
52CDK40.94282179
53MARK20.93798092
54STK40.90999091
55NEK20.88712879
56MAP3K140.88352724
57JAK20.86695091
58NME20.86012373
59TESK20.85940238
60RPS6KA40.85376636
61CDK60.85059797
62EPHB10.82891854
63MAP3K130.82501725
64CSNK1A1L0.82114081
65PIM10.82034502
66CDC42BPA0.80891694
67HIPK20.80193091
68STK380.80022342
69MARK30.76021760
70MAPK120.75375789
71MAP3K30.75172689
72MAP3K10.72850058
73ALK0.72088713
74MELK0.70648972
75KSR20.70261084
76FLT30.65641149
77PASK0.63234613
78TNK20.62710643
79CSNK1G30.61759991
80MAPK40.60404467
81FGFR10.59145195
82INSR0.57193918
83CSNK1G10.56240681
84CSF1R0.55435184
85ICK0.53947667
86CDK90.53830134
87TBK10.52249236
88FGR0.52134009
89PRKD20.51928365
90STK110.50282991
91MAP3K80.49287682
92KDR0.47816255
93CHEK10.47274247
94TSSK60.47263801
95CHUK0.47120765
96FYN0.45164258
97IRAK10.44834014
98MAP3K110.44731065
99ATR0.43944532
100SGK30.43104431
101NTRK20.41999323
102CSNK1G20.41754510
103RET0.41689419
104WNK10.38933642
105PDPK10.38444109
106TAOK10.38009957
107MAPK30.37275974
108FES0.35703087
109PDK10.35645870
110MAPK110.35182512
111ATM0.34917075
112RPS6KL10.34596888
113RPS6KC10.34596888
114TGFBR10.34550835
115NEK60.33918651
116LYN0.33907741
117MAP3K20.33801715
118IKBKB0.33605581
119RPS6KA60.33066085
120LATS10.32060738
121SIK30.31899804
122PDGFRA0.31893171
123PIK3CG0.30885905
124MTOR0.30784629
125CDK20.30619299
126DYRK1B0.29627871
127KIT0.29447153
128MAPK90.29006044
129MKNK20.28827456
130CAMK40.28687344
131UHMK10.28623038
132EPHA30.28509514
133CAMKK20.27682988
134CSNK1D0.26508219

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.53966460
2T cell receptor signaling pathway_Homo sapiens_hsa046604.67092566
3Non-homologous end-joining_Homo sapiens_hsa034503.27540326
4Antigen processing and presentation_Homo sapiens_hsa046122.63048764
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.54692057
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.43421626
7Measles_Homo sapiens_hsa051622.27833268
8Hematopoietic cell lineage_Homo sapiens_hsa046402.12748851
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.09188717
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88245639
11Chronic myeloid leukemia_Homo sapiens_hsa052201.64838711
12Osteoclast differentiation_Homo sapiens_hsa043801.61298487
13Type I diabetes mellitus_Homo sapiens_hsa049401.52381856
14HTLV-I infection_Homo sapiens_hsa051661.47433894
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.46994193
16Spliceosome_Homo sapiens_hsa030401.39827643
17B cell receptor signaling pathway_Homo sapiens_hsa046621.39135594
18Herpes simplex infection_Homo sapiens_hsa051681.37638581
19Viral myocarditis_Homo sapiens_hsa054161.37395272
20Hepatitis B_Homo sapiens_hsa051611.33048330
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29228312
22* Acute myeloid leukemia_Homo sapiens_hsa052211.26312706
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25637549
24DNA replication_Homo sapiens_hsa030301.19186164
25Chemokine signaling pathway_Homo sapiens_hsa040621.18841210
26Tuberculosis_Homo sapiens_hsa051521.18460692
27Staphylococcus aureus infection_Homo sapiens_hsa051501.15353082
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.14395811
29mRNA surveillance pathway_Homo sapiens_hsa030151.10699004
30Non-small cell lung cancer_Homo sapiens_hsa052231.08158440
31Leishmaniasis_Homo sapiens_hsa051401.07920789
32Graft-versus-host disease_Homo sapiens_hsa053321.07567788
33FoxO signaling pathway_Homo sapiens_hsa040681.06652380
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06320582
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06247824
36Allograft rejection_Homo sapiens_hsa053301.05550390
37Pancreatic cancer_Homo sapiens_hsa052121.05065318
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04883008
39Mismatch repair_Homo sapiens_hsa034301.04085444
40Dorso-ventral axis formation_Homo sapiens_hsa043201.02757319
41* Colorectal cancer_Homo sapiens_hsa052101.01937401
42Lysine degradation_Homo sapiens_hsa003100.98979919
43Malaria_Homo sapiens_hsa051440.98246487
44Cell cycle_Homo sapiens_hsa041100.98062328
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96043713
46Toxoplasmosis_Homo sapiens_hsa051450.95805021
47Viral carcinogenesis_Homo sapiens_hsa052030.93263973
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86947528
49Notch signaling pathway_Homo sapiens_hsa043300.83879518
50Platelet activation_Homo sapiens_hsa046110.82999858
51Ribosome_Homo sapiens_hsa030100.82933765
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82693164
53Influenza A_Homo sapiens_hsa051640.82308338
54Base excision repair_Homo sapiens_hsa034100.81161251
55Epstein-Barr virus infection_Homo sapiens_hsa051690.79808781
56Prolactin signaling pathway_Homo sapiens_hsa049170.77961224
57RNA degradation_Homo sapiens_hsa030180.77141173
58Asthma_Homo sapiens_hsa053100.77135431
59Apoptosis_Homo sapiens_hsa042100.75140117
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74249408
61Shigellosis_Homo sapiens_hsa051310.73604106
62MicroRNAs in cancer_Homo sapiens_hsa052060.72701800
63Other glycan degradation_Homo sapiens_hsa005110.72604838
64mTOR signaling pathway_Homo sapiens_hsa041500.72281978
65Small cell lung cancer_Homo sapiens_hsa052220.72017983
66RNA transport_Homo sapiens_hsa030130.71335427
67African trypanosomiasis_Homo sapiens_hsa051430.71147551
68Autoimmune thyroid disease_Homo sapiens_hsa053200.70989534
69VEGF signaling pathway_Homo sapiens_hsa043700.69683130
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.68023811
71Glioma_Homo sapiens_hsa052140.67986935
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.67936094
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66636008
74p53 signaling pathway_Homo sapiens_hsa041150.65159670
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64062943
76TNF signaling pathway_Homo sapiens_hsa046680.63645464
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62717892
78Renal cell carcinoma_Homo sapiens_hsa052110.61634662
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60388906
80Choline metabolism in cancer_Homo sapiens_hsa052310.58867486
81* Prostate cancer_Homo sapiens_hsa052150.58593123
82* Endometrial cancer_Homo sapiens_hsa052130.56437541
83Hepatitis C_Homo sapiens_hsa051600.56393976
84Long-term potentiation_Homo sapiens_hsa047200.55783887
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55783458
86ErbB signaling pathway_Homo sapiens_hsa040120.54310745
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50130336
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49827412
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.49607251
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49316341
91* Pathways in cancer_Homo sapiens_hsa052000.48556466
92GnRH signaling pathway_Homo sapiens_hsa049120.48244093
93Rap1 signaling pathway_Homo sapiens_hsa040150.47216686
94MAPK signaling pathway_Homo sapiens_hsa040100.47115593
95Ras signaling pathway_Homo sapiens_hsa040140.46735288
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46325644
97Insulin resistance_Homo sapiens_hsa049310.45453453
98Proteoglycans in cancer_Homo sapiens_hsa052050.44032557
99Type II diabetes mellitus_Homo sapiens_hsa049300.43779271
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43604977
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43357923
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42774358
103Nucleotide excision repair_Homo sapiens_hsa034200.42496264
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41200239
105Endocytosis_Homo sapiens_hsa041440.39128864
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38762891
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.38571319
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37630680
109Rheumatoid arthritis_Homo sapiens_hsa053230.36491342
110Regulation of autophagy_Homo sapiens_hsa041400.34818288
111Circadian rhythm_Homo sapiens_hsa047100.34699156
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34545877
113* Adherens junction_Homo sapiens_hsa045200.33874343
114One carbon pool by folate_Homo sapiens_hsa006700.32864549
115* Thyroid cancer_Homo sapiens_hsa052160.32846361
116Pertussis_Homo sapiens_hsa051330.32431865
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.32130178
118HIF-1 signaling pathway_Homo sapiens_hsa040660.31645277
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31168467
120Cholinergic synapse_Homo sapiens_hsa047250.30996595
121Estrogen signaling pathway_Homo sapiens_hsa049150.30383155
122Inositol phosphate metabolism_Homo sapiens_hsa005620.28115118
123Legionellosis_Homo sapiens_hsa051340.27313887
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26910054

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