TCF7L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)5.10790903
2regulation of posttranscriptional gene silencing (GO:0060147)5.10790903
3regulation of gene silencing by miRNA (GO:0060964)5.10790903
4paraxial mesoderm development (GO:0048339)4.39406903
5formation of translation preinitiation complex (GO:0001731)4.11066394
6viral transcription (GO:0019083)3.90493925
7L-serine metabolic process (GO:0006563)3.81956151
8ribosomal small subunit biogenesis (GO:0042274)3.80492842
9regulation of cell fate specification (GO:0042659)3.78495905
10DNA replication initiation (GO:0006270)3.76415631
11lung-associated mesenchyme development (GO:0060484)3.74343341
12convergent extension (GO:0060026)3.72605342
13translational termination (GO:0006415)3.71651464
14chromatin remodeling at centromere (GO:0031055)3.65951387
15negative regulation of translation, ncRNA-mediated (GO:0040033)3.65004175
16regulation of translation, ncRNA-mediated (GO:0045974)3.65004175
17negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.65004175
18heterochromatin organization (GO:0070828)3.58625641
19establishment of integrated proviral latency (GO:0075713)3.56424231
20notochord development (GO:0030903)3.54216424
21DNA deamination (GO:0045006)3.53479668
22DNA strand elongation involved in DNA replication (GO:0006271)3.52341452
23ribosomal large subunit biogenesis (GO:0042273)3.52124543
24DNA unwinding involved in DNA replication (GO:0006268)3.51685541
25CENP-A containing nucleosome assembly (GO:0034080)3.39680207
26DNA replication checkpoint (GO:0000076)3.39498549
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.39382325
28translational initiation (GO:0006413)3.37259182
29telomere maintenance via semi-conservative replication (GO:0032201)3.36667562
30DNA strand elongation (GO:0022616)3.33148445
31regulation of nuclear cell cycle DNA replication (GO:0033262)3.32536654
32maturation of SSU-rRNA (GO:0030490)3.31944551
33translational elongation (GO:0006414)3.24365649
34regulation of hippo signaling (GO:0035330)3.23958199
35positive regulation of SMAD protein import into nucleus (GO:0060391)3.23913580
36ribonucleoprotein complex biogenesis (GO:0022613)3.23815173
37establishment of apical/basal cell polarity (GO:0035089)3.23380658
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21083414
39regulation of histone H3-K27 methylation (GO:0061085)3.19763541
40protein localization to kinetochore (GO:0034501)3.17943421
41pre-miRNA processing (GO:0031054)3.16185254
42regulation of double-strand break repair via homologous recombination (GO:0010569)3.16141971
43mitotic metaphase plate congression (GO:0007080)3.15376598
44trophectodermal cell differentiation (GO:0001829)3.13345928
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.11210623
46transcription from mitochondrial promoter (GO:0006390)3.10173741
47histone exchange (GO:0043486)3.09073776
48histone H4-K12 acetylation (GO:0043983)3.04654563
49regulation of cell fate commitment (GO:0010453)3.01349317
50negative regulation of telomerase activity (GO:0051974)2.99622082
51ribosome biogenesis (GO:0042254)2.98871189
52regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.96147062
53spliceosomal snRNP assembly (GO:0000387)2.95680516
54pseudouridine synthesis (GO:0001522)2.93936217
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.93798521
56presynaptic membrane assembly (GO:0097105)2.93494888
57regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.93118369
58somite development (GO:0061053)2.92559465
59mitotic sister chromatid segregation (GO:0000070)2.92290309
60cullin deneddylation (GO:0010388)2.91803500
61maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89770588
62negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.88888419
63telomere maintenance via telomere lengthening (GO:0010833)2.88448943
64regulation of mesoderm development (GO:2000380)2.88219913
65histone arginine methylation (GO:0034969)2.87995661
66kinetochore assembly (GO:0051382)2.87905860
67regulation of double-strand break repair (GO:2000779)2.87388504
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87270644
69viral life cycle (GO:0019058)2.87067630
70protein targeting to ER (GO:0045047)2.85618205
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.85250948
72otic vesicle formation (GO:0030916)2.85118283
73somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84597876
74somatic hypermutation of immunoglobulin genes (GO:0016446)2.84597876
75DNA replication-independent nucleosome organization (GO:0034724)2.84126625
76DNA replication-independent nucleosome assembly (GO:0006336)2.84126625
77negative regulation of gene silencing (GO:0060969)2.84093780
78cotranslational protein targeting to membrane (GO:0006613)2.84071426
79regulation of gene silencing (GO:0060968)2.84032867
80negative regulation of mRNA processing (GO:0050686)2.83887307
81DNA replication-dependent nucleosome assembly (GO:0006335)2.83569813
82DNA replication-dependent nucleosome organization (GO:0034723)2.83569813
83negative regulation of DNA-dependent DNA replication (GO:2000104)2.83340815
84dorsal/ventral axis specification (GO:0009950)2.82638871
85ribosomal small subunit assembly (GO:0000028)2.82359034
86regulation of mitotic spindle checkpoint (GO:1903504)2.82289499
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82289499
88telomere maintenance via recombination (GO:0000722)2.81246694
89proteasome assembly (GO:0043248)2.81016211
90kidney morphogenesis (GO:0060993)2.80695194
91DNA damage response, detection of DNA damage (GO:0042769)2.80406904
92regulation of helicase activity (GO:0051095)2.79287867
93nodal signaling pathway (GO:0038092)2.78150439
94intracellular estrogen receptor signaling pathway (GO:0030520)2.76930431
95branching involved in salivary gland morphogenesis (GO:0060445)2.75413176
96peptidyl-arginine omega-N-methylation (GO:0035247)2.74486446
97somatic stem cell division (GO:0048103)2.74331696
98regulation of non-canonical Wnt signaling pathway (GO:2000050)2.74294611
99cellular protein complex disassembly (GO:0043624)2.73842999
100replication fork processing (GO:0031297)2.72654460
101embryonic camera-type eye development (GO:0031076)2.69318805
102rRNA processing (GO:0006364)2.69180958
103RNA splicing, via transesterification reactions (GO:0000375)2.68386566
104lysine metabolic process (GO:0006553)2.67120742
105lysine catabolic process (GO:0006554)2.67120742
106mitotic nuclear envelope disassembly (GO:0007077)2.65958323
107negative regulation of RNA splicing (GO:0033119)2.65645998
108establishment of protein localization to endoplasmic reticulum (GO:0072599)2.65501268
109protein complex disassembly (GO:0043241)2.65272955
110RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.65193770
111mRNA splicing, via spliceosome (GO:0000398)2.65193770
112establishment of monopolar cell polarity (GO:0061162)2.65150598
113establishment or maintenance of monopolar cell polarity (GO:0061339)2.65150598
114serine family amino acid biosynthetic process (GO:0009070)2.64348767
115termination of RNA polymerase II transcription (GO:0006369)2.64185512
116kinetochore organization (GO:0051383)2.64128253
117lateral sprouting from an epithelium (GO:0060601)2.63008926
118protein localization to chromosome, centromeric region (GO:0071459)2.62209060
119metaphase plate congression (GO:0051310)2.61518923
120G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.61413098
121ATP synthesis coupled proton transport (GO:0015986)2.61288667
122energy coupled proton transport, down electrochemical gradient (GO:0015985)2.61288667
123protein K6-linked ubiquitination (GO:0085020)2.61151597
124cell fate commitment involved in formation of primary germ layer (GO:0060795)2.61075219
125midbrain development (GO:0030901)2.60946147
126chaperone-mediated protein transport (GO:0072321)2.60111741
127protein localization to endoplasmic reticulum (GO:0070972)2.59959529
128rRNA metabolic process (GO:0016072)2.59941292
129negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.59287967
130planar cell polarity pathway involved in neural tube closure (GO:0090179)2.58707241
131regulation of gastrulation (GO:0010470)2.58219132
132mitotic recombination (GO:0006312)2.57929032
133maturation of 5.8S rRNA (GO:0000460)2.57395891
134outer ear morphogenesis (GO:0042473)2.57278996
135negative regulation of cell cycle arrest (GO:0071157)2.57010020
136regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.56726267
137digestive tract morphogenesis (GO:0048546)2.56416311
138protein complex localization (GO:0031503)2.55600581
139nuclear-transcribed mRNA catabolic process (GO:0000956)2.55390843
140mesenchymal to epithelial transition (GO:0060231)2.55265450
141establishment of viral latency (GO:0019043)2.54852615
142negative regulation of androgen receptor signaling pathway (GO:0060766)2.54211073
143polarized epithelial cell differentiation (GO:0030859)2.54101569
144protein deneddylation (GO:0000338)2.54022224
145serine family amino acid catabolic process (GO:0009071)2.53225034
146mitochondrial DNA metabolic process (GO:0032042)2.52802122
147viral mRNA export from host cell nucleus (GO:0046784)2.52455058
148termination of RNA polymerase III transcription (GO:0006386)2.52371501
149transcription elongation from RNA polymerase III promoter (GO:0006385)2.52371501
150proline biosynthetic process (GO:0006561)2.51856852
151positive regulation of DNA-dependent DNA replication (GO:2000105)2.51775721
152negative regulation of cell fate commitment (GO:0010454)2.51592182
153pituitary gland development (GO:0021983)2.50560504
154axon extension involved in axon guidance (GO:0048846)2.50199551
155neuron projection extension involved in neuron projection guidance (GO:1902284)2.50199551
156inner ear receptor cell development (GO:0060119)2.49334203
157glycine metabolic process (GO:0006544)2.48681043
158telomere maintenance via telomerase (GO:0007004)2.46503546
159cranial nerve development (GO:0021545)2.45769656
160prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.45658549
161L-alpha-amino acid transmembrane transport (GO:1902475)2.43763931
162regulation of telomere maintenance via telomerase (GO:0032210)2.43574077
163organ growth (GO:0035265)2.43304243
164non-canonical Wnt signaling pathway (GO:0035567)2.42443196
165presynaptic membrane organization (GO:0097090)2.40834533
166regulation of SMAD protein import into nucleus (GO:0060390)2.39089789
167ATP-dependent chromatin remodeling (GO:0043044)2.38824090
168negative regulation of cell fate specification (GO:0009996)2.37911313
169DNA strand renaturation (GO:0000733)2.35523393
170thalamus development (GO:0021794)2.34995196
171artery development (GO:0060840)2.33094655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.31624590
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.25767257
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.99040503
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.99040503
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.99040503
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.25862547
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12860170
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.00647296
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88767022
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87235351
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71180054
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68016462
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54562610
14SOX2_16153702_ChIP-ChIP_HESCs_Human2.48392183
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48191427
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.46257569
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.44286268
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.43735872
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.37843692
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.33860377
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.29226505
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.26353445
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17301945
24EZH2_22144423_ChIP-Seq_EOC_Human2.13078240
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.10107020
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.09638591
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06231515
28TCF3_18692474_ChIP-Seq_MESCs_Mouse2.05143805
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04189042
30SOX2_18555785_ChIP-Seq_MESCs_Mouse2.00867120
31POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.00195898
32XRN2_22483619_ChIP-Seq_HELA_Human1.97737625
33NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.96060627
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.94734518
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89427863
36SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.88253465
37ZNF274_21170338_ChIP-Seq_K562_Hela1.88228167
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87929398
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85895367
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85250205
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81802746
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81011586
43KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.79326417
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79001302
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76797489
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76566393
47TTF2_22483619_ChIP-Seq_HELA_Human1.72223488
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.71706619
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71179339
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67524679
51* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65543091
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59383602
53VDR_22108803_ChIP-Seq_LS180_Human1.58956534
54MYC_18940864_ChIP-ChIP_HL60_Human1.57663949
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57184649
56EWS_26573619_Chip-Seq_HEK293_Human1.56413953
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.55191555
58MYC_22102868_ChIP-Seq_BL_Human1.54640631
59AR_21909140_ChIP-Seq_LNCAP_Human1.53629438
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52956964
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.52223922
62NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.51870679
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51313859
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48463742
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.47932818
66SOX2_18692474_ChIP-Seq_MEFs_Mouse1.46235521
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45658235
68FUS_26573619_Chip-Seq_HEK293_Human1.43822546
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.41868055
70DCP1A_22483619_ChIP-Seq_HELA_Human1.41255209
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.41202460
72POU5F1_16518401_ChIP-PET_MESCs_Mouse1.40617694
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.40416018
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.40290474
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39648746
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39220048
77P300_19829295_ChIP-Seq_ESCs_Human1.38345954
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33782188
79VDR_23849224_ChIP-Seq_CD4+_Human1.33541267
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32697683
81GABP_19822575_ChIP-Seq_HepG2_Human1.31543591
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30372229
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30165781
84OCT4_18692474_ChIP-Seq_MEFs_Mouse1.29446904
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28821907
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27318161
87TBX3_20139965_ChIP-Seq_ESCs_Mouse1.27022013
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26687857
89TBX3_20139965_ChIP-Seq_MESCs_Mouse1.26659790
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26537356
91POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.26403309
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.25662749
93* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24453125
94* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24453125
95FOXP3_21729870_ChIP-Seq_TREG_Human1.21088865
96ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20136182
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19706528
98TP63_17297297_ChIP-ChIP_HaCaT_Human1.19623195
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19022419
100NANOG_18692474_ChIP-Seq_MEFs_Mouse1.18266496
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17203594
102POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15949805
103KDM5A_27292631_Chip-Seq_BREAST_Human1.15114340
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12998863
105SOX2_18692474_ChIP-Seq_MESCs_Mouse1.12970767
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.12526482
107ELK1_19687146_ChIP-ChIP_HELA_Human1.10642776
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09664196
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07145243
110* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07124494
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06456568
112BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06056132
113EED_16625203_ChIP-ChIP_MESCs_Mouse1.05905852
114EZH2_27304074_Chip-Seq_ESCs_Mouse1.05648373
115TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.05506271
116* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05343631
117CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05059515
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03298089
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03174946
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.02697647
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02606969
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01287697
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01209531
124NOTCH1_21737748_ChIP-Seq_TLL_Human0.99785722
125NANOG_18692474_ChIP-Seq_MESCs_Mouse0.98952666
126VDR_21846776_ChIP-Seq_THP-1_Human0.98370052
127CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98249553
128* SMAD3_21741376_ChIP-Seq_ESCs_Human0.97707552
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97301634
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96726327
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96698370
132* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96604880
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96118558
134GBX2_23144817_ChIP-Seq_PC3_Human0.95170619
135PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95114185
136* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95048565
137NANOG_16153702_ChIP-ChIP_HESCs_Human0.93218583
138SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93191030
139* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93098454
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93077461
141TFEB_21752829_ChIP-Seq_HELA_Human0.92762053
142MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92739908
143POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91559089
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91064129
145PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90319519

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.40850730
2MP0010030_abnormal_orbit_morphology3.99722872
3MP0004957_abnormal_blastocyst_morpholog2.89851698
4MP0008057_abnormal_DNA_replication2.70808514
5MP0003693_abnormal_embryo_hatching2.62354839
6MP0003136_yellow_coat_color2.55716506
7MP0006292_abnormal_olfactory_placode2.52271019
8MP0010094_abnormal_chromosome_stability2.36590790
9MP0003111_abnormal_nucleus_morphology2.34906993
10MP0002249_abnormal_larynx_morphology2.33693264
11MP0002653_abnormal_ependyma_morphology2.24036507
12MP0003077_abnormal_cell_cycle2.19471178
13MP0009053_abnormal_anal_canal2.14428059
14MP0000049_abnormal_middle_ear2.01249195
15MP0008007_abnormal_cellular_replicative2.00792632
16MP0004133_heterotaxia1.97337789
17MP0008932_abnormal_embryonic_tissue1.93351320
18MP0003878_abnormal_ear_physiology1.89521681
19MP0005377_hearing/vestibular/ear_phenot1.89521681
20MP0000566_synostosis1.87274809
21MP0003890_abnormal_embryonic-extraembry1.79831348
22MP0003123_paternal_imprinting1.78376049
23MP0003941_abnormal_skin_development1.76623719
24MP0001293_anophthalmia1.76479675
25MP0003567_abnormal_fetal_cardiomyocyte1.76385869
26MP0008058_abnormal_DNA_repair1.71297903
27* MP0003119_abnormal_digestive_system1.67351063
28* MP0002085_abnormal_embryonic_tissue1.65041584
29MP0001672_abnormal_embryogenesis/_devel1.62757345
30MP0005380_embryogenesis_phenotype1.62757345
31MP0002009_preneoplasia1.59345905
32MP0000350_abnormal_cell_proliferation1.58816641
33MP0001299_abnormal_eye_distance/1.55676677
34MP0010352_gastrointestinal_tract_polyps1.52218487
35MP0000579_abnormal_nail_morphology1.51726986
36MP0004197_abnormal_fetal_growth/weight/1.50876033
37MP0003937_abnormal_limbs/digits/tail_de1.49345942
38MP0003385_abnormal_body_wall1.45888389
39MP0008789_abnormal_olfactory_epithelium1.45871488
40MP0003705_abnormal_hypodermis_morpholog1.45571740
41MP0009379_abnormal_foot_pigmentation1.45486604
42* MP0002084_abnormal_developmental_patter1.45002909
43MP0005367_renal/urinary_system_phenotyp1.44073238
44MP0000516_abnormal_urinary_system1.44073238
45MP0003938_abnormal_ear_development1.44034573
46MP0001485_abnormal_pinna_reflex1.42426297
47MP0003942_abnormal_urinary_system1.41684240
48* MP0001697_abnormal_embryo_size1.41657212
49MP0002932_abnormal_joint_morphology1.41315335
50MP0003984_embryonic_growth_retardation1.41175159
51MP0002088_abnormal_embryonic_growth/wei1.40688265
52MP0009250_abnormal_appendicular_skeleto1.40527351
53MP0003755_abnormal_palate_morphology1.38511734
54MP0000537_abnormal_urethra_morphology1.38324500
55MP0001730_embryonic_growth_arrest1.36905473
56MP0000762_abnormal_tongue_morphology1.35579502
57MP0000678_abnormal_parathyroid_gland1.34633351
58MP0000432_abnormal_head_morphology1.31806289
59MP0002086_abnormal_extraembryonic_tissu1.29894329
60MP0003786_premature_aging1.29108618
61MP0000428_abnormal_craniofacial_morphol1.28610421
62MP0005248_abnormal_Harderian_gland1.28560565
63MP0003315_abnormal_perineum_morphology1.28386635
64MP0004272_abnormal_basement_membrane1.27584039
65MP0003935_abnormal_craniofacial_develop1.27131231
66MP0005508_abnormal_skeleton_morphology1.25691330
67MP0002111_abnormal_tail_morphology1.24697349
68MP0005257_abnormal_intraocular_pressure1.22898450
69MP0000631_abnormal_neuroendocrine_gland1.22033595
70MP0005623_abnormal_meninges_morphology1.20889500
71MP0005394_taste/olfaction_phenotype1.20226352
72MP0005499_abnormal_olfactory_system1.20226352
73MP0005076_abnormal_cell_differentiation1.20137927
74MP0000490_abnormal_crypts_of1.19579041
75MP0001286_abnormal_eye_development1.16781418
76* MP0003861_abnormal_nervous_system1.16413001
77MP0002116_abnormal_craniofacial_bone1.15165373
78MP0000778_abnormal_nervous_system1.12531144
79* MP0002080_prenatal_lethality1.12040210
80MP0002282_abnormal_trachea_morphology1.11109789
81MP0002938_white_spotting1.09954159
82MP0003787_abnormal_imprinting1.07432294
83MP0002697_abnormal_eye_size1.05657635
84MP0005503_abnormal_tendon_morphology1.04810688
85MP0002736_abnormal_nociception_after1.04672399
86MP0006072_abnormal_retinal_apoptosis1.04288949
87MP0002233_abnormal_nose_morphology1.04007530
88MP0003122_maternal_imprinting1.03158276
89MP0003121_genomic_imprinting1.01511579
90MP0002092_abnormal_eye_morphology1.01453164
91MP0002114_abnormal_axial_skeleton1.01345890
92MP0001529_abnormal_vocalization1.00381715
93MP0003283_abnormal_digestive_organ0.98420913
94MP0009278_abnormal_bone_marrow0.95712619
95MP0008438_abnormal_cutaneous_collagen0.93542571
96MP0009384_cardiac_valve_regurgitation0.92929211
97MP0001188_hyperpigmentation0.91464742
98MP0000534_abnormal_ureter_morphology0.91293630
99MP0002751_abnormal_autonomic_nervous0.88989979
100MP0009703_decreased_birth_body0.88841545
101MP0002102_abnormal_ear_morphology0.88627101
102MP0005171_absent_coat_pigmentation0.88625020
103MP0000026_abnormal_inner_ear0.87484719
104MP0003828_pulmonary_edema0.86607797
105MP0003718_maternal_effect0.84429486
106MP0001984_abnormal_olfaction0.84418764
107MP0002177_abnormal_outer_ear0.84319866
108MP0001346_abnormal_lacrimal_gland0.83800827
109MP0005391_vision/eye_phenotype0.83618448
110MP0003115_abnormal_respiratory_system0.82410018
111MP0009672_abnormal_birth_weight0.81865482
112* MP0002925_abnormal_cardiovascular_devel0.80762702
113MP0002160_abnormal_reproductive_system0.79645719
114MP0003011_delayed_dark_adaptation0.79189093
115MP0000613_abnormal_salivary_gland0.79007231
116MP0000858_altered_metastatic_potential0.77686012
117MP0003936_abnormal_reproductive_system0.77685161
118MP0005023_abnormal_wound_healing0.77285176
119MP0001340_abnormal_eyelid_morphology0.76195172
120MP0002108_abnormal_muscle_morphology0.75406696
121MP0002277_abnormal_respiratory_mucosa0.74823572
122MP0000313_abnormal_cell_death0.74400992
123MP0008877_abnormal_DNA_methylation0.73810634
124MP0001177_atelectasis0.70583076
125MP0005195_abnormal_posterior_eye0.70556799
126MP0002752_abnormal_somatic_nervous0.68478257
127MP0002210_abnormal_sex_determination0.68180847
128MP0002081_perinatal_lethality0.67915453
129MP0000647_abnormal_sebaceous_gland0.65368495
130MP0006276_abnormal_autonomic_nervous0.65330235
131MP0004885_abnormal_endolymph0.65190682
132MP0002109_abnormal_limb_morphology0.65151140

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.30125128
2Selective tooth agenesis (HP:0001592)3.27791926
3Absent septum pellucidum (HP:0001331)3.10790975
4Rectal fistula (HP:0100590)3.08107753
5Rectovaginal fistula (HP:0000143)3.08107753
6Supernumerary spleens (HP:0009799)3.07092570
7Breast hypoplasia (HP:0003187)2.99271893
8Absent radius (HP:0003974)2.98240778
9Broad metatarsal (HP:0001783)2.88993517
10Trismus (HP:0000211)2.86968921
11Reticulocytopenia (HP:0001896)2.82809623
12Patellar aplasia (HP:0006443)2.82405498
13Pseudobulbar signs (HP:0002200)2.82164536
14Aplasia involving forearm bones (HP:0009822)2.80657246
15Absent forearm bone (HP:0003953)2.80657246
16Choanal stenosis (HP:0000452)2.75541169
17Optic nerve hypoplasia (HP:0000609)2.74808643
18Concave nail (HP:0001598)2.74106428
19Aplasia/Hypoplasia of the patella (HP:0006498)2.73796223
20Intestinal fistula (HP:0100819)2.72606956
21Short hallux (HP:0010109)2.72542574
22Abnormal lung lobation (HP:0002101)2.69130424
23Absent thumb (HP:0009777)2.68017628
24Abnormal hemoglobin (HP:0011902)2.66420717
25Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.63818415
26Abnormality of the septum pellucidum (HP:0007375)2.63282392
27Abnormality of the phalanges of the hallux (HP:0010057)2.63027188
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58665497
29Short 4th metacarpal (HP:0010044)2.58665497
30Abdominal situs inversus (HP:0003363)2.58188478
31Abnormality of abdominal situs (HP:0011620)2.58188478
32Aplasia/hypoplasia of the humerus (HP:0006507)2.57980548
33Abnormal number of incisors (HP:0011064)2.57037712
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.53735758
35Atresia of the external auditory canal (HP:0000413)2.53720587
36Vaginal fistula (HP:0004320)2.52744411
37Aplasia/Hypoplasia of the hallux (HP:0008362)2.48871894
38Abnormality of the ileum (HP:0001549)2.48255008
39Meckel diverticulum (HP:0002245)2.43021191
40Rhabdomyosarcoma (HP:0002859)2.39157715
41Triphalangeal thumb (HP:0001199)2.37744963
42Abnormality of the aortic arch (HP:0012303)2.35975859
43Hepatoblastoma (HP:0002884)2.35967738
44Short humerus (HP:0005792)2.34856425
45Broad toe (HP:0001837)2.27684448
46Turricephaly (HP:0000262)2.27352163
47Supernumerary bones of the axial skeleton (HP:0009144)2.27176772
48Impulsivity (HP:0100710)2.27080407
49Pancreatic fibrosis (HP:0100732)2.26856430
50Abnormality of cells of the erythroid lineage (HP:0012130)2.25096719
51Pendular nystagmus (HP:0012043)2.24256410
52Hypoplasia of the radius (HP:0002984)2.23304649
53Gastrointestinal atresia (HP:0002589)2.22948487
54Preaxial foot polydactyly (HP:0001841)2.22843507
55Sex reversal (HP:0012245)2.21670251
56Abnormal sex determination (HP:0012244)2.21670251
57Protrusio acetabuli (HP:0003179)2.21158762
58Supernumerary ribs (HP:0005815)2.19795286
59Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19293190
60Partial duplication of the phalanx of hand (HP:0009999)2.19082889
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18698365
62Shawl scrotum (HP:0000049)2.18627633
63Abnormality of the middle phalanges of the toes (HP:0010183)2.18538296
64Bifid tongue (HP:0010297)2.18390595
65Neoplasm of striated muscle (HP:0009728)2.15708142
66Multiple enchondromatosis (HP:0005701)2.15114060
67Septo-optic dysplasia (HP:0100842)2.13817280
68Carpal bone hypoplasia (HP:0001498)2.13629284
69Aqueductal stenosis (HP:0002410)2.13019848
70Short 5th finger (HP:0009237)2.12933328
71Bronchomalacia (HP:0002780)2.12491921
72Missing ribs (HP:0000921)2.12389772
73Hyperglycinuria (HP:0003108)2.12360394
74Hemivertebrae (HP:0002937)2.10357099
75Facial hemangioma (HP:0000329)2.10176509
76Synostosis involving the elbow (HP:0003938)2.08968871
77Humeroradial synostosis (HP:0003041)2.08968871
78Abnormal number of erythroid precursors (HP:0012131)2.08615875
79True hermaphroditism (HP:0010459)2.08388014
80Abnormality of the lacrimal duct (HP:0011481)2.07994755
81Preauricular skin tag (HP:0000384)2.07114695
82Chromsome breakage (HP:0040012)2.06652567
83Cutaneous finger syndactyly (HP:0010554)2.06586833
84Shallow orbits (HP:0000586)2.06400559
85Vitreoretinal degeneration (HP:0000655)2.05651387
86Colon cancer (HP:0003003)2.04688344
87Nephroblastoma (Wilms tumor) (HP:0002667)2.04647784
88Intestinal atresia (HP:0011100)2.04532978
89Stenosis of the external auditory canal (HP:0000402)2.03851528
90Breast aplasia (HP:0100783)2.02563025
91Cutaneous syndactyly (HP:0012725)2.01062465
92Vertebral fusion (HP:0002948)1.99671860
93Broad hallux (HP:0010055)1.98340779
94Tracheoesophageal fistula (HP:0002575)1.96507316
95Embryonal renal neoplasm (HP:0011794)1.96319235
96Medulloblastoma (HP:0002885)1.96247168
97Abnormality of midbrain morphology (HP:0002418)1.96128400
98Molar tooth sign on MRI (HP:0002419)1.96128400
99Pancreatic cysts (HP:0001737)1.96021210
100Hyperglycinemia (HP:0002154)1.95391456
101Aplasia/Hypoplasia of the breasts (HP:0010311)1.95292070
102Maternal diabetes (HP:0009800)1.94814547
103Anencephaly (HP:0002323)1.94799229
104Bilateral microphthalmos (HP:0007633)1.94742667
105Aplasia/Hypoplasia of the uvula (HP:0010293)1.94570416
106Broad thumb (HP:0011304)1.94430477
107Renal duplication (HP:0000075)1.94120948
108Abnormality of the 4th metacarpal (HP:0010012)1.93748124
109Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.92831312
110Partial duplication of thumb phalanx (HP:0009944)1.92240903
111Fused cervical vertebrae (HP:0002949)1.92077248
112Aplasia/Hypoplasia of the sternum (HP:0006714)1.91934413
113Skin tags (HP:0010609)1.91820018
114Trigonocephaly (HP:0000243)1.91265849
115Abnormality of the distal phalanx of the thumb (HP:0009617)1.90538360
116Anophthalmia (HP:0000528)1.89762196
117Duplication of thumb phalanx (HP:0009942)1.88017165
118Birth length less than 3rd percentile (HP:0003561)1.87286330
119Abnormality of the nasolacrimal system (HP:0000614)1.86880838
120Abnormality of the anterior horn cell (HP:0006802)1.85859973
121Degeneration of anterior horn cells (HP:0002398)1.85859973
122Ankle contracture (HP:0006466)1.85700626
123Ectopic kidney (HP:0000086)1.83917692
124Carpal synostosis (HP:0009702)1.83456490
125Adrenal hypoplasia (HP:0000835)1.83115276
126Cleft eyelid (HP:0000625)1.82652354
127Sclerocornea (HP:0000647)1.81574956
128Testicular atrophy (HP:0000029)1.79452446
129Renal hypoplasia (HP:0000089)1.78638237
130Holoprosencephaly (HP:0001360)1.78062905
131Short thumb (HP:0009778)1.77597845
132Coronal craniosynostosis (HP:0004440)1.76769542
133Esophageal atresia (HP:0002032)1.76285784
134Dandy-Walker malformation (HP:0001305)1.75948782
135Short middle phalanx of the 5th finger (HP:0004220)1.74882388
136Abnormality of the fetal cardiovascular system (HP:0010948)1.74786924
137Abnormal umbilical cord blood vessels (HP:0011403)1.74786924
138Single umbilical artery (HP:0001195)1.74786924
139Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74466752
140Macrocytic anemia (HP:0001972)1.74076356
141Nephronophthisis (HP:0000090)1.72839883
142Asplenia (HP:0001746)1.72064470
143Preaxial hand polydactyly (HP:0001177)1.70938701
144Abnormality of the labia minora (HP:0012880)1.70852847
145Ependymoma (HP:0002888)1.70577521
146Hypoplastic female external genitalia (HP:0012815)1.69489153
147Labial hypoplasia (HP:0000066)1.68549459
148Hypoplasia of the pons (HP:0012110)1.67977183
149Abnormality of serine family amino acid metabolism (HP:0010894)1.67880648
150Abnormality of glycine metabolism (HP:0010895)1.67880648
151Broad phalanges of the hand (HP:0009768)1.67833080
152Increased hepatocellular lipid droplets (HP:0006565)1.66790288
153Chronic bronchitis (HP:0004469)1.66437933
154Broad finger (HP:0001500)1.66290965
155Broad long bones (HP:0005622)1.65631079
156Facial cleft (HP:0002006)1.64931367
157Myelomeningocele (HP:0002475)1.64832139
158Vaginal atresia (HP:0000148)1.64101116
159Congenital, generalized hypertrichosis (HP:0004540)1.63437055
160Scrotal hypoplasia (HP:0000046)1.62780367
161Abnormality of the incisor (HP:0000676)1.62427377
162Aplasia of the phalanges of the hand (HP:0009802)1.61349316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.05600155
2TNIK3.57649755
3CDK123.43020010
4PRKD23.02417073
5NME22.98807614
6BUB12.91821549
7TAF12.60691419
8CDC72.47792252
9CDK72.46333321
10TLK12.39811901
11WEE12.38746437
12MKNK22.34125430
13LATS22.27594839
14PNCK2.21361503
15MKNK12.21110277
16FGFR22.20021799
17ZAK2.14901399
18STK382.12646013
19DDR22.07142251
20WNK32.00026920
21DYRK31.99238710
22NUAK11.92861974
23TSSK61.91726561
24TTK1.87972490
25ICK1.85267456
26BMPR1B1.85049397
27STK38L1.83351433
28CLK11.82267905
29NLK1.81964993
30SRPK11.81272750
31MAP3K101.71037783
32TIE11.66375414
33NEK21.64651598
34PLK11.64490386
35EPHA21.55014953
36STK101.53073302
37EIF2AK11.48784840
38AKT31.42002023
39MAPK151.41116901
40NME11.38113130
41CDK191.33767799
42EPHB21.33272555
43PIM11.32805683
44YES11.30915244
45CHEK21.29982986
46LATS11.26304967
47MAP3K111.26161553
48ADRBK21.24756897
49PLK41.23397449
50CDK41.20094465
51TGFBR11.19010656
52AURKA1.17253754
53GRK11.16634877
54AURKB1.14595064
55BMX1.14287965
56RPS6KA41.12349668
57UHMK11.07927612
58TESK21.06186598
59INSRR1.04845464
60GRK61.02441215
61TYRO30.98939861
62RPS6KB20.98109025
63PBK0.93962562
64ATR0.93928903
65CDK60.93903241
66HIPK20.87649641
67MAP3K60.86828821
68PRKCI0.86103976
69DYRK20.84559743
70MAP3K80.82428956
71STK160.82251097
72PAK40.79441088
73CAMK1G0.79349438
74PIM20.77982020
75PAK10.76649493
76EIF2AK20.76495892
77DYRK1B0.76082421
78CDK20.75585374
79CHEK10.75072786
80ACVR1B0.74914133
81BRD40.73547999
82TAOK20.73484710
83PRKCG0.73352234
84FGR0.73107451
85DMPK0.72518470
86MTOR0.71995974
87OXSR10.71925841
88VRK10.71837726
89KDR0.71211579
90MATK0.70989291
91CASK0.70945219
92AKT20.69102452
93BRSK20.68991418
94CSNK2A10.68457939
95RPS6KC10.67472869
96RPS6KL10.67472869
97PDGFRA0.66260908
98SMG10.65995987
99EIF2AK30.65723334
100NTRK10.65650073
101CSNK1E0.65428871
102MAP2K30.64941407
103PLK30.64425074
104CDK80.63749962
105TGFBR20.63551358
106STK30.62334148
107MAP3K40.62220639
108BCKDK0.59176120
109CDK30.58610489
110NEK10.58375415
111MUSK0.58325001
112STK40.57694330
113ERBB40.57029764
114ATM0.56133717
115MST40.55138637
116PASK0.54391449
117CSK0.54237404
118CAMK1D0.54179286
119STK240.53838786
120RPS6KA60.53717506
121CSNK2A20.53539188
122PLK20.52232316
123GSK3A0.51366889
124CSNK1G20.51102028
125MAP3K90.50702624
126MAP2K20.50386506
127PRKCE0.49961152
128NTRK20.49923414
129RPS6KA10.49112195
130PRKDC0.49091846
131PRPF4B0.46718687
132MELK0.46634716
133MAP4K20.45865137
134CDK10.45250518
135CSNK1G10.44362669
136FGFR10.43633307
137ERBB20.43575500
138WNK40.42456633
139ALK0.42032639
140CDK90.41366648
141MAPKAPK20.38213302
142STK110.38114281
143DYRK1A0.36915770
144CAMK10.36894811
145PINK10.36061823
146CSNK1G30.35932083
147TRIM280.33651262
148CSNK1A10.31767025
149PAK20.30090300
150FLT30.29809161

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.29968296
2Ribosome_Homo sapiens_hsa030103.92369035
3Mismatch repair_Homo sapiens_hsa034303.52937914
4Spliceosome_Homo sapiens_hsa030403.50703365
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.38448577
6Base excision repair_Homo sapiens_hsa034103.24147964
7RNA transport_Homo sapiens_hsa030132.90327951
8RNA polymerase_Homo sapiens_hsa030202.84672431
9Homologous recombination_Homo sapiens_hsa034402.74352543
10Cell cycle_Homo sapiens_hsa041102.46023313
11Nucleotide excision repair_Homo sapiens_hsa034202.37902938
12One carbon pool by folate_Homo sapiens_hsa006702.32925636
13mRNA surveillance pathway_Homo sapiens_hsa030152.21626826
14* Basal cell carcinoma_Homo sapiens_hsa052172.15628316
15Oxidative phosphorylation_Homo sapiens_hsa001902.13019482
16Fanconi anemia pathway_Homo sapiens_hsa034602.11090695
17Pyrimidine metabolism_Homo sapiens_hsa002401.95298844
18Basal transcription factors_Homo sapiens_hsa030221.94313665
19Parkinsons disease_Homo sapiens_hsa050121.93247392
20Hedgehog signaling pathway_Homo sapiens_hsa043401.86635216
21p53 signaling pathway_Homo sapiens_hsa041151.75880927
22Protein export_Homo sapiens_hsa030601.75807162
23* Hippo signaling pathway_Homo sapiens_hsa043901.72166348
24RNA degradation_Homo sapiens_hsa030181.65040212
25Proteasome_Homo sapiens_hsa030501.61079049
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57328035
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.52086879
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49374817
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44913162
30Cardiac muscle contraction_Homo sapiens_hsa042601.44665779
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39456809
32TGF-beta signaling pathway_Homo sapiens_hsa043501.35725777
33Notch signaling pathway_Homo sapiens_hsa043301.33019203
34Phototransduction_Homo sapiens_hsa047441.29896925
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27571640
36MicroRNAs in cancer_Homo sapiens_hsa052061.24759501
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24553006
38Sulfur relay system_Homo sapiens_hsa041221.19192150
39* Adherens junction_Homo sapiens_hsa045201.18561733
40Steroid biosynthesis_Homo sapiens_hsa001001.17942462
41Bladder cancer_Homo sapiens_hsa052191.16680856
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13548877
43* Wnt signaling pathway_Homo sapiens_hsa043101.11642392
44Alzheimers disease_Homo sapiens_hsa050101.11195989
45Propanoate metabolism_Homo sapiens_hsa006401.09207598
46* Thyroid cancer_Homo sapiens_hsa052161.07140187
47Pyruvate metabolism_Homo sapiens_hsa006201.06149310
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02539753
49Vitamin digestion and absorption_Homo sapiens_hsa049770.99821550
50Small cell lung cancer_Homo sapiens_hsa052220.98255182
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95302971
52HTLV-I infection_Homo sapiens_hsa051660.91884831
53Herpes simplex infection_Homo sapiens_hsa051680.91642992
54Tight junction_Homo sapiens_hsa045300.90403776
55Epstein-Barr virus infection_Homo sapiens_hsa051690.89956092
56Non-homologous end-joining_Homo sapiens_hsa034500.88462263
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87710753
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86862165
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85192402
60Arachidonic acid metabolism_Homo sapiens_hsa005900.84087074
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81659707
62Purine metabolism_Homo sapiens_hsa002300.81032589
63Nitrogen metabolism_Homo sapiens_hsa009100.80466476
64* Pathways in cancer_Homo sapiens_hsa052000.78930340
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78631975
66Vitamin B6 metabolism_Homo sapiens_hsa007500.77739936
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77383124
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76633897
69Tryptophan metabolism_Homo sapiens_hsa003800.76458899
70Retinol metabolism_Homo sapiens_hsa008300.76402836
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74915332
72Axon guidance_Homo sapiens_hsa043600.74702255
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74241766
74Butanoate metabolism_Homo sapiens_hsa006500.73953546
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73702504
76Folate biosynthesis_Homo sapiens_hsa007900.73680590
77beta-Alanine metabolism_Homo sapiens_hsa004100.72436150
78ECM-receptor interaction_Homo sapiens_hsa045120.72090812
79* Prostate cancer_Homo sapiens_hsa052150.70777154
80Nicotine addiction_Homo sapiens_hsa050330.70444013
81Melanoma_Homo sapiens_hsa052180.70063373
82* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65827024
83Oocyte meiosis_Homo sapiens_hsa041140.65500796
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.64716114
85Taste transduction_Homo sapiens_hsa047420.62607657
86Proteoglycans in cancer_Homo sapiens_hsa052050.60889789
87Metabolic pathways_Homo sapiens_hsa011000.59032423
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.57971854
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57753615
90Glutathione metabolism_Homo sapiens_hsa004800.55894120
91Fat digestion and absorption_Homo sapiens_hsa049750.55228312
92Linoleic acid metabolism_Homo sapiens_hsa005910.53996378
93Focal adhesion_Homo sapiens_hsa045100.53240252
94Viral carcinogenesis_Homo sapiens_hsa052030.52589162
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.51099293
96Fatty acid elongation_Homo sapiens_hsa000620.49735158
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49187198
98Antigen processing and presentation_Homo sapiens_hsa046120.48488119
99Chronic myeloid leukemia_Homo sapiens_hsa052200.48241011
100Caffeine metabolism_Homo sapiens_hsa002320.48019281
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46486411
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46476855
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44823218
104Histidine metabolism_Homo sapiens_hsa003400.41633710
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41594715
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41243682
107Lysine degradation_Homo sapiens_hsa003100.40026487
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39934999
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39555460
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.39495598
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38863491
112Biosynthesis of amino acids_Homo sapiens_hsa012300.38566680
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38514393
114Ether lipid metabolism_Homo sapiens_hsa005650.36904812
115Viral myocarditis_Homo sapiens_hsa054160.35795636
116Fatty acid degradation_Homo sapiens_hsa000710.35412824
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35046214
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34706125
119Apoptosis_Homo sapiens_hsa042100.33667847
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33012631
121Galactose metabolism_Homo sapiens_hsa000520.32842020
122Arginine and proline metabolism_Homo sapiens_hsa003300.32154935
123mTOR signaling pathway_Homo sapiens_hsa041500.31782456
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31604512
125Shigellosis_Homo sapiens_hsa051310.31574088
126Measles_Homo sapiens_hsa051620.31141076
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.30681227
128Fructose and mannose metabolism_Homo sapiens_hsa000510.30149056
129Protein digestion and absorption_Homo sapiens_hsa049740.29188111
130Huntingtons disease_Homo sapiens_hsa050160.28960218
131* Colorectal cancer_Homo sapiens_hsa052100.28479308
132* Acute myeloid leukemia_Homo sapiens_hsa052210.28304114
133Legionellosis_Homo sapiens_hsa051340.27327114
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.26564672
135Selenocompound metabolism_Homo sapiens_hsa004500.25662573
136Hepatitis B_Homo sapiens_hsa051610.24438667
137* Melanogenesis_Homo sapiens_hsa049160.24253374
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24151696
139Rap1 signaling pathway_Homo sapiens_hsa040150.20729311
140HIF-1 signaling pathway_Homo sapiens_hsa040660.16895166
141Fatty acid biosynthesis_Homo sapiens_hsa000610.16681811
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.16360224
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16118168
144FoxO signaling pathway_Homo sapiens_hsa040680.14249024
145AMPK signaling pathway_Homo sapiens_hsa041520.14078683

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