TCHH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene forms crosslinked complexes with itself and keratin intermediate filaments to provide mechanical strength to the hair follicle inner root sheath. The encoded protein also is important for structural integrity of the filiform papillae of the tongue. Defects in this gene are a cause of uncombable hair syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host cell (GO:0044650)9.99900157
2virion attachment to host cell (GO:0019062)9.99900157
3citrulline biosynthetic process (GO:0019240)8.86907316
4peptide cross-linking (GO:0018149)8.57934107
5adhesion of symbiont to host (GO:0044406)8.43831521
6hair follicle morphogenesis (GO:0031069)8.41125983
7linoleic acid metabolic process (GO:0043651)6.99994766
8intermediate filament cytoskeleton organization (GO:0045104)6.91246018
9intermediate filament-based process (GO:0045103)6.69245288
10epidermis development (GO:0008544)6.24641779
11citrulline metabolic process (GO:0000052)5.87372752
12keratinocyte differentiation (GO:0030216)5.83403707
13long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.78402683
14cell wall macromolecule catabolic process (GO:0016998)5.74338566
15cell wall macromolecule metabolic process (GO:0044036)5.74338566
16hair cycle process (GO:0022405)5.44063556
17molting cycle process (GO:0022404)5.44063556
18establishment of skin barrier (GO:0061436)5.41768846
19long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.38647322
20bundle of His cell to Purkinje myocyte communication (GO:0086069)5.25752813
21hemidesmosome assembly (GO:0031581)5.24114488
22fatty-acyl-CoA biosynthetic process (GO:0046949)5.12238728
23peptidyl-arginine modification (GO:0018195)4.88888369
24regulation of water loss via skin (GO:0033561)4.84562262
25keratinocyte proliferation (GO:0043616)4.77528438
26skin morphogenesis (GO:0043589)4.68191612
27epidermal cell differentiation (GO:0009913)4.55531422
28long-chain fatty acid biosynthetic process (GO:0042759)4.54599863
29retinol metabolic process (GO:0042572)4.31519172
30thioester biosynthetic process (GO:0035384)4.18990197
31acyl-CoA biosynthetic process (GO:0071616)4.18990197
32fatty-acyl-CoA metabolic process (GO:0035337)4.18623381
33hair cycle (GO:0042633)34.8761439
34molting cycle (GO:0042303)34.8761439
35keratinocyte development (GO:0003334)3.88189072
36lipoxygenase pathway (GO:0019372)3.86268439
37positive regulation of keratinocyte differentiation (GO:0045618)3.78413850
38tooth mineralization (GO:0034505)3.75773142
39negative regulation of keratinocyte proliferation (GO:0010839)3.43060146
40positive regulation of chemokine secretion (GO:0090197)3.32485021
41phosphatidylinositol acyl-chain remodeling (GO:0036149)3.32354909
42regulation of keratinocyte differentiation (GO:0045616)3.32177112
43alpha-linolenic acid metabolic process (GO:0036109)3.31955304
44defense response to fungus (GO:0050832)3.28975818
45multicellular organismal water homeostasis (GO:0050891)3.27204973
46hair follicle development (GO:0001942)3.25045975
47positive regulation of hair cycle (GO:0042635)3.24410727
48positive regulation of hair follicle development (GO:0051798)3.24410727
49negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.23937886
50primary alcohol metabolic process (GO:0034308)3.15038170
51regulation of hair follicle development (GO:0051797)3.04154018
52phosphatidylserine acyl-chain remodeling (GO:0036150)3.03474735
53regulation of chemokine secretion (GO:0090196)2.99140206
54bone trabecula formation (GO:0060346)2.98484967
55epithelium development (GO:0060429)2.96912583
56triglyceride biosynthetic process (GO:0019432)2.93832971
57ectoderm development (GO:0007398)2.91848586
58gap junction assembly (GO:0016264)2.91095153
59phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.80096034
60regulation of sequestering of triglyceride (GO:0010889)2.79227655
61acylglycerol biosynthetic process (GO:0046463)2.75704158
62neutral lipid biosynthetic process (GO:0046460)2.75704158
63positive regulation of epidermis development (GO:0045684)2.74975118
64regulation of hair cycle (GO:0042634)2.74921072
65positive regulation of meiotic cell cycle (GO:0051446)2.73681824
66water homeostasis (GO:0030104)2.67777947
67negative regulation of protein localization to plasma membrane (GO:1903077)2.67762771
68atrioventricular valve morphogenesis (GO:0003181)2.64323952
69disruption of cells of other organism (GO:0044364)2.62812297
70killing of cells of other organism (GO:0031640)2.62812297
71regulation of epidermal cell differentiation (GO:0045604)2.58808024
72regulation of epidermis development (GO:0045682)2.52885674
73epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49809524
74detection of bacterium (GO:0016045)2.48304376
75epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.46766890
76fatty acid elongation (GO:0030497)2.43661571
77ventricular cardiac muscle cell action potential (GO:0086005)2.42052056
78regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.37544125
79thioester metabolic process (GO:0035383)2.37336415
80acyl-CoA metabolic process (GO:0006637)2.37336415
81regulation of natural killer cell differentiation (GO:0032823)2.33560902
82wound healing, spreading of epidermal cells (GO:0035313)2.32979761
83negative regulation of cell fate specification (GO:0009996)2.30556860
84phosphatidylserine metabolic process (GO:0006658)2.30053233
85cell surface receptor signaling pathway involved in heart development (GO:0061311)2.27888447
86positive regulation of epidermal cell differentiation (GO:0045606)2.27174957
87response to phenylpropanoid (GO:0080184)2.24179552
88positive regulation of monocyte chemotaxis (GO:0090026)2.23357246
89detection of other organism (GO:0098543)2.23239796
90phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.22256353
91regulation of defense response to virus by host (GO:0050691)2.21356212
92cranial suture morphogenesis (GO:0060363)2.19814942
93carnitine metabolic process (GO:0009437)2.19476681
94skin development (GO:0043588)2.16693232
95regulation of mesenchymal cell apoptotic process (GO:2001053)2.16145705
96unsaturated fatty acid biosynthetic process (GO:0006636)2.14950148
97response to fungus (GO:0009620)2.09953311
98fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.08482949
99aging (GO:0007568)2.04783710
100regulation of cardioblast differentiation (GO:0051890)2.03102177
101regulation of heart rate by cardiac conduction (GO:0086091)2.00713682
102planar cell polarity pathway involved in neural tube closure (GO:0090179)2.00009882
103intermediate filament organization (GO:0045109)12.4290473
104desmosome organization (GO:0002934)10.3147247
105* keratinization (GO:0031424)10.0352258
106regulation of ruffle assembly (GO:1900027)1.99982161
107cytoskeletal anchoring at plasma membrane (GO:0007016)1.99862105
108epithelial cell-cell adhesion (GO:0090136)1.99685302
109lymph vessel development (GO:0001945)1.99345938
110fatty acid biosynthetic process (GO:0006633)1.99288435
111one-carbon compound transport (GO:0019755)1.98571671
112negative regulation of epidermis development (GO:0045683)1.98227627
113phosphatidylcholine acyl-chain remodeling (GO:0036151)1.96794883
114cell communication involved in cardiac conduction (GO:0086065)1.93795781
115regulation of keratinocyte proliferation (GO:0010837)1.93132866
116cell-substrate junction assembly (GO:0007044)1.91543928
117outflow tract septum morphogenesis (GO:0003148)1.91237954
118regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.90811009
119myotube differentiation (GO:0014902)1.84770437
120regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.84178267
121ephrin receptor signaling pathway (GO:0048013)1.83936117
122phosphatidic acid metabolic process (GO:0046473)1.82484048
123phosphatidic acid biosynthetic process (GO:0006654)1.82484048
124non-canonical Wnt signaling pathway (GO:0035567)1.81803839
125sphingoid metabolic process (GO:0046519)1.79263333
126ceramide biosynthetic process (GO:0046513)1.78356941
127ethanol metabolic process (GO:0006067)1.72795225
128alditol phosphate metabolic process (GO:0052646)1.69721362
129regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.68646753
130negative regulation of interferon-gamma production (GO:0032689)1.67766922
131establishment of planar polarity (GO:0001736)1.66556501
132establishment of tissue polarity (GO:0007164)1.66556501
133lipid storage (GO:0019915)1.64724560
134wound healing, spreading of cells (GO:0044319)1.63115361
135antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.63095513
136antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.63095513
137lateral sprouting from an epithelium (GO:0060601)1.62420974
138regulation of phospholipase A2 activity (GO:0032429)1.61586357
139craniofacial suture morphogenesis (GO:0097094)1.60065159
140regulation of monocyte chemotaxis (GO:0090025)1.59728669
141eyelid development in camera-type eye (GO:0061029)1.58784850
142G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.57528019
143primary alcohol catabolic process (GO:0034310)1.56905046
144regulation of transforming growth factor beta2 production (GO:0032909)1.56740976
145cardiac conduction (GO:0061337)1.56290730
146very long-chain fatty acid metabolic process (GO:0000038)1.56240959
147coronary vasculature morphogenesis (GO:0060977)1.55906256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.73407040
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.95277316
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.56551027
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.73736373
5CTCF_20526341_ChIP-Seq_ESCs_Human2.32212680
6BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.10999185
7NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.07107314
8TP63_17297297_ChIP-ChIP_HaCaT_Human13.0679176
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91974643
10E2F1_20622854_ChIP-Seq_HELA_Human1.83962132
11TAF2_19829295_ChIP-Seq_ESCs_Human1.80701971
12EGR1_19032775_ChIP-ChIP_M12_Human1.74553432
13SOX9_24532713_ChIP-Seq_HFSC_Mouse1.70718978
14P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.70693405
15CSB_26484114_Chip-Seq_FIBROBLAST_Human1.70519350
16NANOG_20526341_ChIP-Seq_ESCs_Human1.67878557
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.67534653
18ERG_20517297_ChIP-Seq_VCAP_Human1.58621459
19P53_21459846_ChIP-Seq_SAOS-2_Human1.57746851
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55743147
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55743147
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.54733622
23RACK7_27058665_Chip-Seq_MCF-7_Human1.53870143
24TP53_20018659_ChIP-ChIP_R1E_Mouse1.53121567
25TP63_22573176_ChIP-Seq_HFKS_Human1.49919209
26DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47746722
27MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.47144721
28BCL6_27268052_Chip-Seq_Bcells_Human1.47105295
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.43650583
30* CTCF_27219007_Chip-Seq_Bcells_Human1.43280106
31YY1_22570637_ChIP-Seq_MALME-3M_Human1.41953409
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41079192
33BCOR_27268052_Chip-Seq_Bcells_Human1.39843219
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39266837
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38040912
36ATF3_27146783_Chip-Seq_COLON_Human1.36737235
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36577197
38* LXR_22292898_ChIP-Seq_THP-1_Human1.33469811
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.31003296
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.29015569
41AHR_22903824_ChIP-Seq_MCF-7_Human1.26956085
42* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25771243
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24745188
44PHF8_20622854_ChIP-Seq_HELA_Human1.24731657
45P68_20966046_ChIP-Seq_HELA_Human1.21788682
46SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20967840
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.20547571
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.19054699
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.18191361
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17565187
51CEBPB_22108803_ChIP-Seq_LS180_Human1.16298146
52E2F1_17053090_ChIP-ChIP_MCF-7_Human1.14917840
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14591808
54TP63_23658742_ChIP-Seq_EP156T_Human1.11943174
55JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11050706
56GATA3_24758297_ChIP-Seq_MCF-7_Human1.10950821
57RAC3_21632823_ChIP-Seq_H3396_Human1.09590924
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08126582
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08063833
60ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07672231
61SMC4_20622854_ChIP-Seq_HELA_Human1.07608705
62GATA4_25053715_ChIP-Seq_YYC3_Human1.06443047
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06441971
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05896530
65* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04723578
66SPI1_20517297_ChIP-Seq_HL60_Human1.01706166
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.01580578
68SOX2_21211035_ChIP-Seq_LN229_Human0.99624290
69KLF5_25053715_ChIP-Seq_YYC3_Human0.99000042
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97225540
71* UBF1/2_26484160_Chip-Seq_HMECs_Human0.96578436
72RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95782741
73ERG_21242973_ChIP-ChIP_JURKAT_Human0.95519489
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92585538
75FOXH1_21741376_ChIP-Seq_ESCs_Human0.91668412
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90641328
77RUNX1_27514584_Chip-Seq_MCF-7_Human0.89556059
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89465229
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88949269
80RXR_22108803_ChIP-Seq_LS180_Human0.87756290
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87561283
82CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87148293
83HTT_18923047_ChIP-ChIP_STHdh_Human0.86819307
84SOX2_20726797_ChIP-Seq_SW620_Human0.85838738
85* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.85796172
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85586055
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.84486362
88* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83207899
89ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80276178
90* RNF2_27304074_Chip-Seq_ESCs_Mouse0.78995567
91ZNF263_19887448_ChIP-Seq_K562_Human0.78204327
92* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77793102
93ELK3_25401928_ChIP-Seq_HUVEC_Human0.77618713
94AR_21572438_ChIP-Seq_LNCaP_Human0.76990585
95P300_27268052_Chip-Seq_Bcells_Human0.76675193
96HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76407676
97TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.75669350
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75443263
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74647517
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74457272
101* RING1B_27294783_Chip-Seq_ESCs_Mouse0.74414909
102* GATA6_21074721_ChIP-Seq_CACO-2_Human0.74231818
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.73918229
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73834600
105FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73414170
106FOXA1_25329375_ChIP-Seq_VCAP_Human0.73414170
107* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.71803003
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71741432
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71741432
110STAT1_20625510_ChIP-Seq_HELA_Human0.71144394
111EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.69920150
112HNFA_21074721_ChIP-Seq_CACO-2_Human0.69579204
113CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.68432016
114PPARA_22158963_ChIP-Seq_LIVER_Mouse0.68236754
115SOX2_27498859_Chip-Seq_STOMACH_Mouse0.68165702
116RBPJ_21746931_ChIP-Seq_IB4_Human0.65837180
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.65002181
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.64624686
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.64624686
120SMAD4_21741376_ChIP-Seq_ESCs_Human0.64235791
121RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.63405803
122* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.62545440
123EGR1_23403033_ChIP-Seq_LIVER_Mouse0.61150134
124SA1_27219007_Chip-Seq_Bcells_Human0.60962159
125BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.60758755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.83765118
2MP0002098_abnormal_vibrissa_morphology7.12806601
3MP0000647_abnormal_sebaceous_gland6.31516730
4MP0002796_impaired_skin_barrier5.73071424
5MP0010234_abnormal_vibrissa_follicle5.07188131
6MP0005275_abnormal_skin_tensile5.04402264
7MP0000383_abnormal_hair_follicle4.70577832
8MP0010678_abnormal_skin_adnexa4.16297857
9MP0000377_abnormal_hair_follicle4.06521724
10MP0003705_abnormal_hypodermis_morpholog3.69599260
11MP0005501_abnormal_skin_physiology3.59514059
12MP0000427_abnormal_hair_cycle3.46064034
13MP0002254_reproductive_system_inflammat3.10722298
14MP0001216_abnormal_epidermal_layer2.68096421
15MP0004381_abnormal_hair_follicle2.64277322
16MP0000367_abnormal_coat/_hair2.36752084
17MP0010771_integument_phenotype2.29064659
18MP0003453_abnormal_keratinocyte_physiol2.24323160
19MP0004947_skin_inflammation2.24016350
20MP0003878_abnormal_ear_physiology2.20435431
21MP0005377_hearing/vestibular/ear_phenot2.20435431
22MP0002060_abnormal_skin_morphology2.18157960
23MP0001243_abnormal_dermal_layer2.15845754
24MP0002234_abnormal_pharynx_morphology1.96886679
25MP0000467_abnormal_esophagus_morphology1.89280266
26MP0001188_hyperpigmentation1.85059170
27MP0000762_abnormal_tongue_morphology1.57935085
28MP0009053_abnormal_anal_canal1.52805402
29MP0003566_abnormal_cell_adhesion1.50793477
30MP0009931_abnormal_skin_appearance1.49619902
31MP0005409_darkened_coat_color1.47562173
32MP0003941_abnormal_skin_development1.20912739
33MP0005647_abnormal_sex_gland1.13711983
34MP0001191_abnormal_skin_condition1.00542229
35MP0004885_abnormal_endolymph0.99231104
36MP0004264_abnormal_extraembryonic_tissu0.96824671
37MP0004185_abnormal_adipocyte_glucose0.92729985
38MP0000015_abnormal_ear_pigmentation0.85890498
39MP0005174_abnormal_tail_pigmentation0.82969753
40MP0001851_eye_inflammation0.80537313
41MP0002095_abnormal_skin_pigmentation0.78187878
42MP0008438_abnormal_cutaneous_collagen0.77945373
43MP0006035_abnormal_mitochondrial_morpho0.72762349
44MP0003315_abnormal_perineum_morphology0.68725120
45MP0001849_ear_inflammation0.68004246
46MP0002877_abnormal_melanocyte_morpholog0.67941699
47MP0001661_extended_life_span0.66440336
48MP0000566_synostosis0.65051053
49MP0001346_abnormal_lacrimal_gland0.64825997
50MP0001340_abnormal_eyelid_morphology0.64144906
51MP0010030_abnormal_orbit_morphology0.60195643
52MP0003191_abnormal_cellular_cholesterol0.57927261
53MP0002282_abnormal_trachea_morphology0.57060873
54MP0000627_abnormal_mammary_gland0.56841485
55MP0004782_abnormal_surfactant_physiolog0.54192120
56MP0005023_abnormal_wound_healing0.52324739
57MP0003755_abnormal_palate_morphology0.52039686
58MP0005451_abnormal_body_composition0.49919966
59MP0002970_abnormal_white_adipose0.46893265
60MP0001784_abnormal_fluid_regulation0.43526420
61MP0001485_abnormal_pinna_reflex0.40782818
62MP0002111_abnormal_tail_morphology0.40549832
63MP0010352_gastrointestinal_tract_polyps0.36472323
64MP0002249_abnormal_larynx_morphology0.35757211
65MP0004272_abnormal_basement_membrane0.35017309
66MP0003385_abnormal_body_wall0.34171793
67MP0005075_abnormal_melanosome_morpholog0.33349814
68MP0005535_abnormal_body_temperature0.31643887
69MP0000537_abnormal_urethra_morphology0.30144259
70MP0009840_abnormal_foam_cell0.28122934
71MP0002177_abnormal_outer_ear0.27359620
72MP0000678_abnormal_parathyroid_gland0.26465555
73MP0002163_abnormal_gland_morphology0.26008890
74MP0001919_abnormal_reproductive_system0.25538777
75MP0002697_abnormal_eye_size0.25095285
76MP0003763_abnormal_thymus_physiology0.24998123
77MP0000465_gastrointestinal_hemorrhage0.24526022
78MP0003950_abnormal_plasma_membrane0.23762279
79MP0005248_abnormal_Harderian_gland0.23033261
80MP0006054_spinal_hemorrhage0.22786216
81MP0000685_abnormal_immune_system0.22014581
82MP0003329_amyloid_beta_deposits0.21861027
83MP0003300_gastrointestinal_ulcer0.21589650
84MP0002138_abnormal_hepatobiliary_system0.20938930
85MP0000432_abnormal_head_morphology0.19761477
86MP0005503_abnormal_tendon_morphology0.18390297
87MP0004019_abnormal_vitamin_homeostasis0.18165871
88MP0005666_abnormal_adipose_tissue0.17254801
89MP0002971_abnormal_brown_adipose0.17030208
90MP0009780_abnormal_chondrocyte_physiolo0.16846410
91MP0003448_altered_tumor_morphology0.15915919
92MP0003935_abnormal_craniofacial_develop0.15745599
93MP0001879_abnormal_lymphatic_vessel0.15425891
94MP0001984_abnormal_olfaction0.15147182
95MP0004742_abnormal_vestibular_system0.14685691
96MP0005375_adipose_tissue_phenotype0.14184903
97MP0004858_abnormal_nervous_system0.14101618
98MP0005076_abnormal_cell_differentiation0.13635375
99MP0009379_abnormal_foot_pigmentation0.12852407
100MP0002166_altered_tumor_susceptibility0.12688874
101MP0003638_abnormal_response/metabolism_0.12617384
102MP0002006_tumorigenesis0.12419413
103MP0001958_emphysema0.11385707
104MP0000604_amyloidosis0.11165229
105MP0003045_fibrosis0.11094070
106MP0002233_abnormal_nose_morphology0.11012860
107MP0001853_heart_inflammation0.10974498
108MP0000462_abnormal_digestive_system0.10812234
109MP0005193_abnormal_anterior_eye0.10647873
110MP0009384_cardiac_valve_regurgitation0.10376502
111MP0005452_abnormal_adipose_tissue0.10221921
112MP0000516_abnormal_urinary_system0.09278813
113MP0005367_renal/urinary_system_phenotyp0.09278813
114MP0005379_endocrine/exocrine_gland_phen0.08990366
115MP0003075_altered_response_to0.08634719
116MP0009703_decreased_birth_body0.07816556
117MP0003011_delayed_dark_adaptation0.07590822
118MP0005508_abnormal_skeleton_morphology0.07168485
119MP0001186_pigmentation_phenotype0.07145728
120MP0009333_abnormal_splenocyte_physiolog0.07035679
121MP0002009_preneoplasia0.05953891
122MP0000428_abnormal_craniofacial_morphol0.05918252
123MP0004043_abnormal_pH_regulation0.05879987
124MP0008004_abnormal_stomach_pH0.05544782
125MP0003646_muscle_fatigue0.05418392
126MP0000733_abnormal_muscle_development0.05321422
127MP0006138_congestive_heart_failure0.04931000
128MP0005646_abnormal_pituitary_gland0.04815286
129MP0005165_increased_susceptibility_to0.04781501
130MP0000358_abnormal_cell_content/0.03452681
131MP0001765_abnormal_ion_homeostasis0.02270613
132MP0002148_abnormal_hypersensitivity_rea0.02159355
133MP0001881_abnormal_mammary_gland0.01236932

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.02189199
2Nail dystrophy (HP:0008404)7.42594650
3Abnormality of nail color (HP:0100643)6.65401210
4Abnormal hair laboratory examination (HP:0003328)5.73732094
5Fragile nails (HP:0001808)5.68980597
6Absent eyebrow (HP:0002223)5.38211335
7Fine hair (HP:0002213)5.27638073
8Alopecia of scalp (HP:0002293)5.19284625
9Absent hair (HP:0002298)4.93729741
10Palmoplantar hyperkeratosis (HP:0000972)4.87603264
11Thick nail (HP:0001805)4.85348599
12Follicular hyperkeratosis (HP:0007502)4.62222408
13Onycholysis (HP:0001806)4.60796340
14Palmar hyperkeratosis (HP:0010765)4.58979224
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.52676383
16Plantar hyperkeratosis (HP:0007556)4.47646540
17Right ventricular cardiomyopathy (HP:0011663)4.22354584
18Abnormality of the axillary hair (HP:0100134)4.18270579
19Abnormality of secondary sexual hair (HP:0009888)4.18270579
20Increased IgE level (HP:0003212)4.16860496
21Oral leukoplakia (HP:0002745)3.65459515
22Sparse eyelashes (HP:0000653)3.57911923
23Milia (HP:0001056)3.53190889
24Erythema (HP:0010783)3.30544756
25Parakeratosis (HP:0001036)3.08730250
26Amelogenesis imperfecta (HP:0000705)3.06964605
27Abnormality of the frontal sinuses (HP:0002687)3.06730430
28Ridged nail (HP:0001807)2.80848240
29Curly hair (HP:0002212)2.76337488
30Erythroderma (HP:0001019)2.74642667
31Congenital, generalized hypertrichosis (HP:0004540)2.67908539
32Intention tremor (HP:0002080)2.58357384
33Aplasia cutis congenita (HP:0001057)2.51218430
34Abnormal blistering of the skin (HP:0008066)2.48273548
35Dry hair (HP:0011359)2.44578398
36Congenital ichthyosiform erythroderma (HP:0007431)2.44088479
37Natal tooth (HP:0000695)2.41078704
38Neck muscle weakness (HP:0000467)2.38813666
39Torticollis (HP:0000473)2.36833510
40Hamartoma of the eye (HP:0010568)2.29011845
41Advanced eruption of teeth (HP:0006288)2.28435002
42Hypohidrosis (HP:0000966)2.12972650
43Corneal erosion (HP:0200020)2.08395086
44Palmoplantar keratoderma (HP:0000982)2.04886995
45Hypotrichosis (HP:0001006)14.6342048
46Slow-growing hair (HP:0002217)11.1393707
47Abnormality of hair growth rate (HP:0011363)11.1393707
48Woolly hair (HP:0002224)11.1379917
49Brittle hair (HP:0002299)10.2964877
50Craniofacial dystonia (HP:0012179)1.99504926
51Ventricular tachycardia (HP:0004756)1.97419747
52Coarse hair (HP:0002208)1.96385077
53Pruritus (HP:0000989)1.90004675
54Abnormality of the parietal bone (HP:0002696)1.88011895
55Concave nail (HP:0001598)1.85501716
56Difficulty walking (HP:0002355)1.83787050
57Abnormality of the pupil (HP:0000615)1.82710042
58Focal dystonia (HP:0004373)1.82276666
59Ventricular fibrillation (HP:0001663)1.78743133
60Abnormality of the dental root (HP:0006486)1.76401464
61Taurodontia (HP:0000679)1.76401464
62Abnormality of permanent molar morphology (HP:0011071)1.76401464
63Absent eyelashes (HP:0000561)1.75403217
64Fatigable weakness (HP:0003473)1.73857135
65Abnormality of the neuromuscular junction (HP:0003398)1.73857135
66Abnormality of molar (HP:0011077)1.73711346
67Abnormality of molar morphology (HP:0011070)1.73711346
68Abnormality of dental color (HP:0011073)1.71293111
69Widely patent fontanelles and sutures (HP:0004492)1.69465372
70Blepharitis (HP:0000498)1.63344150
71Recurrent corneal erosions (HP:0000495)1.62634727
72Furrowed tongue (HP:0000221)1.55009542
73Urticaria (HP:0001025)1.54681349
74Abnormality of placental membranes (HP:0011409)1.54348947
75Amniotic constriction ring (HP:0009775)1.54348947
76Abnormality of the dental pulp (HP:0006479)1.54329386
77Hyporeflexia of lower limbs (HP:0002600)1.51710569
78Carious teeth (HP:0000670)1.48398934
79Abnormality of the salivary glands (HP:0010286)1.47579424
80Lip pit (HP:0100267)1.47503086
81Anonychia (HP:0001798)1.45338981
82Acanthosis nigricans (HP:0000956)1.44987451
83Heterogeneous (HP:0001425)1.42804860
84Sudden death (HP:0001699)1.40982467
85Keratoconjunctivitis sicca (HP:0001097)1.40327290
86Unilateral renal agenesis (HP:0000122)1.37545316
87Atrophic scars (HP:0001075)1.37170950
88Abnormality of the aortic arch (HP:0012303)1.36730618
89Ectropion (HP:0000656)1.34915060
90Autoamputation (HP:0001218)1.34376456
91Abnormality of the fingernails (HP:0001231)1.33451205
92Achilles tendon contracture (HP:0001771)1.32354320
93Laryngomalacia (HP:0001601)1.32251522
94Craniofacial hyperostosis (HP:0004493)1.32099267
95Distal lower limb muscle weakness (HP:0009053)1.30116065
96Multifactorial inheritance (HP:0001426)1.29753967
97Neonatal onset (HP:0003623)1.28535554
98Conjunctival hamartoma (HP:0100780)1.26687827
99Gangrene (HP:0100758)1.25863901
100Keratoconjunctivitis (HP:0001096)1.24858385
101Abnormality of the Achilles tendon (HP:0005109)1.24507272
102Hypergammaglobulinemia (HP:0010702)1.19639787
103Selective tooth agenesis (HP:0001592)1.19060678
104Variable expressivity (HP:0003828)1.19015518
105Sparse scalp hair (HP:0002209)1.18043162
106Hyperhidrosis (HP:0000975)1.16571180
107Septate vagina (HP:0001153)1.16088487
108Hamartoma (HP:0010566)1.15655184
109Skin ulcer (HP:0200042)1.14253270
110Corneal dystrophy (HP:0001131)1.13924075
111Lack of skin elasticity (HP:0100679)1.13906924
112Melanocytic nevus (HP:0000995)1.13899061
113Abnormality of the gastric mucosa (HP:0004295)1.13624488
114Widely spaced teeth (HP:0000687)1.13498527
115Increased connective tissue (HP:0009025)1.12685983
116Dehydration (HP:0001944)1.03299810
117Generalized hyperpigmentation (HP:0007440)0.98766019
118Aplasia involving bones of the extremities (HP:0009825)0.98430493
119Aplasia involving bones of the upper limbs (HP:0009823)0.98430493
120Aplasia of the phalanges of the hand (HP:0009802)0.98430493
121Conical tooth (HP:0000698)0.96255006
122Dry skin (HP:0000958)0.96022288
123Neonatal death (HP:0003811)0.95673086
124Cranial hyperostosis (HP:0004437)0.94056322
125Nasolacrimal duct obstruction (HP:0000579)0.93670971
126Verrucae (HP:0200043)0.87521163
127Papilloma (HP:0012740)0.87521163
128Seborrheic dermatitis (HP:0001051)0.85879762
129Hypoplastic toenails (HP:0001800)0.85412396
130Hypoplastic labia majora (HP:0000059)0.85400462
131Acanthocytosis (HP:0001927)0.83874920
132Eczematoid dermatitis (HP:0000976)0.83820891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.42334534
2FER4.17029651
3MAPKAPK34.02204024
4ERN13.90191160
5MAP3K63.62015613
6EPHB23.13578256
7TAOK12.99002124
8STK242.90654681
9MAP3K32.70186374
10TRIB32.66993523
11LATS12.64215145
12MAP3K22.35594650
13MAP3K111.96057540
14RPS6KB21.90483043
15EPHB11.89390095
16PRPF4B1.88398946
17EEF2K1.81509547
18LATS21.75227291
19MAP2K61.73851072
20TTN1.64253416
21IRAK11.55648862
22FGFR41.55082111
23PIK3CG1.47324693
24MAP3K11.36417501
25ABL21.36337553
26FGFR21.35575146
27RIPK11.34621273
28NME11.32864394
29KSR21.32069139
30BCR1.30625188
31BMX1.28967729
32MAPKAPK51.26714373
33MST1R1.26395026
34IKBKB1.24945657
35SIK11.23352458
36FGFR31.21705473
37STK391.18064661
38CDK61.17905536
39IRAK21.17761812
40PINK11.16812085
41MAPK71.15474403
42SMG11.15459580
43PKN21.11253307
44BLK1.07480767
45PDGFRA1.07190674
46PTK61.06511807
47MAP2K31.05225271
48MAPKAPK21.03675026
49FGFR11.02878228
50LMTK21.01479980
51MAP3K70.97627258
52LRRK20.95565270
53IRAK30.94983626
54MAP2K40.93162323
55MAP3K90.92060265
56RPS6KB10.90628541
57RPS6KA40.88509282
58DDR20.88195026
59EPHA30.87479500
60MYLK0.85964859
61MARK20.85422394
62STK380.83785737
63CHUK0.82442534
64PBK0.81841235
65MAP2K10.81161736
66STK38L0.81064650
67PTK20.80022412
68NME20.76693894
69PRKD20.76182007
70PAK30.71450924
71SGK2230.70128285
72SGK4940.70128285
73MET0.69765987
74PAK40.68285361
75PRKD10.67680312
76MAP3K100.66412613
77ERBB40.66111681
78PIM20.65846466
79PKN10.65366700
80DYRK1B0.65279246
81PRKCI0.62244641
82TBK10.61280558
83TESK10.61042755
84JAK10.61034230
85IKBKE0.59137841
86MAPK40.55536706
87TRPM70.55371131
88ALK0.55133285
89TYRO30.52994635
90RET0.52952603
91PAK60.52376481
92NTRK20.52223811
93ERBB20.51991055
94CDC42BPA0.51971869
95PRKCH0.51937368
96TYK20.51803515
97PDGFRB0.51668256
98TGFBR10.51170905
99MAP3K50.50196330
100CDK190.48948234
101ICK0.48134863
102PAK20.46711634
103RPS6KA10.46642760
104PDPK10.45095605
105MAP3K140.45088410
106PRKAA20.43445326
107SGK30.43381869
108GSK3A0.42358015
109JAK20.41503838
110MST40.40480666
111CDK120.39805281
112CSNK1E0.39265531
113SGK20.39159470
114MAPK120.38706372
115NEK60.38703623
116MAP2K20.38471263
117TAOK20.37179621
118NEK10.36049760
119RPS6KA20.36018125
120ERBB30.34700676
121HIPK20.34368018
122YES10.33983473
123OXSR10.33026998
124CLK10.32679245
125NLK0.30407920
126CDK70.29565106
127FYN0.29227053
128DYRK30.28925293
129HCK0.27310584
130STK30.27237359
131MAP3K80.26920974
132GRK60.26349574
133SRC0.26146814
134ILK0.25883277
135TGFBR20.25180057
136CSNK1A10.24575118
137MAPK80.23604791
138MTOR0.22456947
139PRKACG0.22327532
140STK110.21304739
141LIMK10.21001649
142CSNK1D0.20368154
143MATK0.20117259

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.81805911
2Linoleic acid metabolism_Homo sapiens_hsa005914.78741499
3Vitamin digestion and absorption_Homo sapiens_hsa049773.82849839
4Fat digestion and absorption_Homo sapiens_hsa049753.05344420
5Fatty acid biosynthesis_Homo sapiens_hsa000612.82113926
6Ether lipid metabolism_Homo sapiens_hsa005652.50859020
7Fatty acid elongation_Homo sapiens_hsa000622.50412219
8Basal cell carcinoma_Homo sapiens_hsa052172.41439101
9Sphingolipid metabolism_Homo sapiens_hsa006002.15367984
10Arachidonic acid metabolism_Homo sapiens_hsa005901.87966540
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.83496050
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.81464236
13Phenylalanine metabolism_Homo sapiens_hsa003601.77334195
14VEGF signaling pathway_Homo sapiens_hsa043701.72117914
15Retinol metabolism_Homo sapiens_hsa008301.69276681
16Melanogenesis_Homo sapiens_hsa049161.60573276
17Ovarian steroidogenesis_Homo sapiens_hsa049131.57773790
18Hedgehog signaling pathway_Homo sapiens_hsa043401.56327969
19Axon guidance_Homo sapiens_hsa043601.52072008
20Caffeine metabolism_Homo sapiens_hsa002321.45889425
21Histidine metabolism_Homo sapiens_hsa003401.45141233
22Bladder cancer_Homo sapiens_hsa052191.44586377
23Thyroid cancer_Homo sapiens_hsa052161.37051295
24Proteoglycans in cancer_Homo sapiens_hsa052051.33647720
25Glioma_Homo sapiens_hsa052141.33135027
26Hippo signaling pathway_Homo sapiens_hsa043901.32067808
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.25412802
28Glycerolipid metabolism_Homo sapiens_hsa005611.24678319
29GnRH signaling pathway_Homo sapiens_hsa049121.23090418
30Acute myeloid leukemia_Homo sapiens_hsa052211.21426780
31Dorso-ventral axis formation_Homo sapiens_hsa043201.15642994
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15530808
33Collecting duct acid secretion_Homo sapiens_hsa049661.15236452
34Tight junction_Homo sapiens_hsa045301.09738530
35Mineral absorption_Homo sapiens_hsa049781.08893515
36ECM-receptor interaction_Homo sapiens_hsa045121.07464515
37Pancreatic secretion_Homo sapiens_hsa049721.06053003
38Lysosome_Homo sapiens_hsa041421.05049931
39Adherens junction_Homo sapiens_hsa045201.00841685
40PPAR signaling pathway_Homo sapiens_hsa033201.00797154
41Long-term potentiation_Homo sapiens_hsa047200.99700942
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99214059
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96529576
44Nitrogen metabolism_Homo sapiens_hsa009100.93841587
45Endometrial cancer_Homo sapiens_hsa052130.92372562
46Non-small cell lung cancer_Homo sapiens_hsa052230.91513624
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.89803844
48Steroid biosynthesis_Homo sapiens_hsa001000.88019999
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86401848
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85546250
51Tyrosine metabolism_Homo sapiens_hsa003500.83867138
52Pertussis_Homo sapiens_hsa051330.83148310
53Long-term depression_Homo sapiens_hsa047300.83116330
54beta-Alanine metabolism_Homo sapiens_hsa004100.82801835
55Ras signaling pathway_Homo sapiens_hsa040140.81948293
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81737147
57Estrogen signaling pathway_Homo sapiens_hsa049150.81289424
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.80582220
59Wnt signaling pathway_Homo sapiens_hsa043100.80243563
60Amoebiasis_Homo sapiens_hsa051460.79567909
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77189903
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74057325
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.72676218
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70421227
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.69049089
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68618400
67Serotonergic synapse_Homo sapiens_hsa047260.68269284
68MicroRNAs in cancer_Homo sapiens_hsa052060.66697493
69Staphylococcus aureus infection_Homo sapiens_hsa051500.64405675
70Protein digestion and absorption_Homo sapiens_hsa049740.63839190
71Hepatitis C_Homo sapiens_hsa051600.62952502
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.62489163
73Malaria_Homo sapiens_hsa051440.62098631
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61792239
75Gastric acid secretion_Homo sapiens_hsa049710.61336710
76Insulin resistance_Homo sapiens_hsa049310.60920680
77Rap1 signaling pathway_Homo sapiens_hsa040150.58787956
78Renin secretion_Homo sapiens_hsa049240.57104381
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57092157
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56922568
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56534112
82Focal adhesion_Homo sapiens_hsa045100.56269656
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.55898502
84Gap junction_Homo sapiens_hsa045400.55432618
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55161961
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54615522
87Salmonella infection_Homo sapiens_hsa051320.53458071
88Renal cell carcinoma_Homo sapiens_hsa052110.53132451
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.51692498
90ErbB signaling pathway_Homo sapiens_hsa040120.51039116
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49729397
92Platelet activation_Homo sapiens_hsa046110.48634396
93Circadian rhythm_Homo sapiens_hsa047100.48147632
94Fatty acid metabolism_Homo sapiens_hsa012120.47975793
95Salivary secretion_Homo sapiens_hsa049700.47073461
96Vibrio cholerae infection_Homo sapiens_hsa051100.46963244
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46959576
98TGF-beta signaling pathway_Homo sapiens_hsa043500.46887631
99Butanoate metabolism_Homo sapiens_hsa006500.46784302
100Choline metabolism in cancer_Homo sapiens_hsa052310.46737086
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.45443202
102Oxytocin signaling pathway_Homo sapiens_hsa049210.44242959
103Phototransduction_Homo sapiens_hsa047440.43945764
104Toxoplasmosis_Homo sapiens_hsa051450.43726820
105Prolactin signaling pathway_Homo sapiens_hsa049170.43044264
106Chronic myeloid leukemia_Homo sapiens_hsa052200.42779219
107Notch signaling pathway_Homo sapiens_hsa043300.42288673
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41840697
109Amphetamine addiction_Homo sapiens_hsa050310.40254891
110Tuberculosis_Homo sapiens_hsa051520.39218436
111Olfactory transduction_Homo sapiens_hsa047400.38874872
112Melanoma_Homo sapiens_hsa052180.38474230
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38296037
114Alcoholism_Homo sapiens_hsa050340.38148879
115p53 signaling pathway_Homo sapiens_hsa041150.37238997
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37001131
117Prion diseases_Homo sapiens_hsa050200.36869401
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36360704
119Pathways in cancer_Homo sapiens_hsa052000.35766494
120Chemical carcinogenesis_Homo sapiens_hsa052040.35456812
121Fatty acid degradation_Homo sapiens_hsa000710.34500365
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34142613
123Circadian entrainment_Homo sapiens_hsa047130.33143888
124Peroxisome_Homo sapiens_hsa041460.32997996
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32619648
126Synaptic vesicle cycle_Homo sapiens_hsa047210.31752234
127Insulin signaling pathway_Homo sapiens_hsa049100.31657653
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30058019
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28396246
130Inositol phosphate metabolism_Homo sapiens_hsa005620.25955289
131Systemic lupus erythematosus_Homo sapiens_hsa053220.25921722
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.25771714
133Rheumatoid arthritis_Homo sapiens_hsa053230.25138783
134Glucagon signaling pathway_Homo sapiens_hsa049220.24996092
135Pyruvate metabolism_Homo sapiens_hsa006200.24735254
136Phagosome_Homo sapiens_hsa041450.23030846
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20862321
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15042286

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